                         SEQUENCE LISTING

<110>  H. Lundbeck A/S
 
<120>  Method of upregulating SorLA for the treatment of Alzheimer's 
       Disease

<130>  0720-WO-PCT

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  10924
<212>  DNA
<213>  Homo sapiens

<400>  1
ccggcccagc ggctctcctg gcctcgcgct gcacattctc tcctggcggc ggcgccacct       60

gcagtagcgt tcgcccgaac atggcgacac ggagcagcag gagggagtcg cgactcccgt      120

tcctattcac cctggtcgca ctgctgccgc ccggagctct ctgcgaagtc tggacgcaga      180

ggctgcacgg cggcagcgcg cccttgcccc aggaccgggg cttcctcgtg gtgcagggcg      240

acccgcgcga gctgcggctg tgggcgcgcg gggatgccag gggggcgagc cgcgcggacg      300

agaagccgct ccggaggaaa cggagcgctg ccctgcagcc cgagcccatc aaggtgtacg      360

gacaggttag tctgaatgat tcccacaatc agatggtggt gcactgggct ggagagaaaa      420

gcaacgtgat cgtggccttg gcccgagata gcctggcatt ggcgaggccc aagagcagtg      480

atgtgtacgt gtcttacgac tatggaaaat cattcaagaa aatttcagac aagttaaact      540

ttggcttggg aaataggagt gaagctgtta tcgcccagtt ctaccacagc cctgcggaca      600

acaagcggta catctttgca gacgcttatg cccagtacct ctggatcacg tttgacttct      660

gcaacactct tcaaggcttt tccatcccat ttcgggcagc tgatctcctc ctacacagta      720

aggcctccaa ccttctcttg ggctttgaca ggtcccaccc caacaagcag ctgtggaagt      780

cagatgactt tggccagacc tggatcatga ttcaggaaca tgtcaagtcc ttttcttggg      840

gaattgatcc ctatgacaaa ccaaatacca tctacattga acgacatgaa ccctctggct      900

actccactgt cttccgaagt acagatttct tccagtcccg ggaaaaccag gaagtgatcc      960

ttgaggaagt gagagatttt cagcttcggg acaagtacat gtttgctaca aaggtggtgc     1020

atctcttggg cagtgaacag cagtcttctg tccagctctg ggtctccttt ggccggaagc     1080

ccatgagagc agcccagttt gtcacaagac atcctattaa tgaatattac atcgcagatg     1140

cctccgagga ccaggtgttt gtgtgtgtca gccacagtaa caaccgcacc aatttataca     1200

tctcagaggc agaggggctg aagttctccc tgtccttgga gaacgtgctc tattacagcc     1260

caggaggggc cggcagtgac accttggtga ggtattttgc aaatgaacca tttgctgact     1320

tccaccgagt ggaaggattg caaggagtct acattgctac tctgattaat ggttctatga     1380

atgaggagaa catgagatcg gtcatcacct ttgacaaagg gggaacctgg gagtttcttc     1440

aggctccagc cttcacggga tatggagaga aaatcaattg tgagctttcc cagggctgtt     1500

cccttcatct ggctcagcgc ctcagtcagc tcctcaacct ccagctccgg agaatgccca     1560

tcctgtccaa ggagtcggct ccaggcctca tcatcgccac tggctcagtg ggaaagaact     1620

tggctagcaa gacaaacgtg tacatctcta gcagtgctgg agccaggtgg cgagaggcac     1680

ttcctggacc tcactactac acatggggag accacggcgg aatcatcacg gccattgccc     1740

agggcatgga aaccaacgag ctaaaataca gtaccaatga aggggagacc tggaaaacat     1800

tcatcttctc tgagaagcca gtgtttgtgt atggcctcct cacagaacct ggggagaaga     1860

gcactgtctt caccatcttt ggctcgaaca aagagaatgt ccacagctgg ctgatcctcc     1920

aggtcaatgc cacggatgcc ttgggagttc cctgcacaga gaatgactac aagctgtggt     1980

caccatctga tgagcggggg aatgagtgtt tgctgggaca caagactgtt ttcaaacggc     2040

ggacccccca tgccacatgc ttcaatggag aggactttga caggccggtg gtcgtgtcca     2100

actgctcctg cacccgggag gactatgagt gtgacttcgg tttcaagatg agtgaagatt     2160

tgtcattaga ggtttgtgtt ccagatccgg aattttctgg aaagtcatac tcccctcctg     2220

tgccttgccc tgtgggttct acttacagga gaacgagagg ctaccggaag atttctgggg     2280

acacttgtag cggaggagat gttgaagcgc gactggaagg agagctggtc ccctgtcccc     2340

tggcagaaga gaacgagttc attctgtatg ctgtgaggaa atccatctac cgctatgacc     2400

tggcctcggg agccaccgag cagttgcctc tcaccgggct acgggcagca gtggccctgg     2460

actttgacta tgagcacaac tgtttgtatt ggtccgacct ggccttggac gtcatccagc     2520

gcctctgttt gaatggaagc acagggcaag aggtgatcat caattctggc ctggagacag     2580

tagaagcttt ggcttttgaa cccctcagcc agctgcttta ctgggtagat gcaggcttca     2640

aaaagattga ggtagctaat ccagatggcg acttccgact cacaatcgtc aattcctctg     2700

tgcttgatcg tcccagggct ctggtcctcg tgccccaaga gggggtgatg ttctggacag     2760

actggggaga cctgaagcct gggatttatc ggagcaatat ggatggttct gctgcctatc     2820

acctggtgtc tgaggatgtg aagtggccca atggcatctc tgtggacgac cagtggattt     2880

actggacgga tgcctacctg gagtgcatag agcggatcac gttcagtggc cagcagcgct     2940

ctgtcattct ggacaacctc ccgcacccct atgccattgc tgtctttaag aatgaaatct     3000

actgggatga ctggtcacag ctcagcatat tccgagcttc caaatacagt gggtcccaga     3060

tggagattct ggcaaaccag ctcacggggc tcatggacat gaagattttc tacaagggga     3120

agaacactgg aagcaatgcc tgtgtgccca ggccatgcag cctgctgtgc ctgcccaagg     3180

ccaacaacag tagaagctgc aggtgtccag aggatgtgtc cagcagtgtg cttccatcag     3240

gggacctgat gtgtgactgc cctcagggct atcagctcaa gaacaatacc tgtgtcaaag     3300

aagagaacac ctgtcttcgc aaccagtatc gctgcagcaa cgggaactgt atcaacagca     3360

tttggtggtg tgactttgac aacgactgtg gagacatgag cgatgagaga aactgcccta     3420

ccaccatctg tgacctggac acccagtttc gttgccagga gtctgggact tgtatcccac     3480

tgtcctataa atgtgacctt gaggatgact gtggagacaa cagtgatgaa agtcattgtg     3540

aaatgcacca gtgccggagt gacgagtaca actgcagttc cggcatgtgc atccgctcct     3600

cctgggtatg tgacggggac aacgactgca gggactggtc tgatgaagcc aactgtaccg     3660

ccatctatca cacctgtgag gcctccaact tccagtgccg aaacgggcac tgcatccccc     3720

agcggtgggc gtgtgacggg gatacggact gccaggatgg ttccgatgag gatccagtca     3780

actgtgagaa gaagtgcaat ggattccgct gcccaaacgg cacttgcatc ccatccagca     3840

aacattgtga tggtctgcgt gattgctctg atggctccga tgaacagcac tgcgagcccc     3900

tctgtacgca cttcatggac tttgtgtgta agaaccgcca gcagtgcctg ttccactcca     3960

tggtctgtga cggaatcatc cagtgccgcg acgggtccga tgaggatgcg gcgtttgcag     4020

gatgctccca agatcctgag ttccacaagg tatgtgatga gttcggtttc cagtgtcaga     4080

atggagtgtg catcagtttg atttggaagt gcgacgggat ggatgattgc ggcgattatt     4140

ctgatgaagc caactgcgaa aaccccacag aagccccaaa ctgctcccgc tacttccagt     4200

ttcggtgtga gaatggccac tgcatcccca acagatggaa atgtgacagg gagaacgact     4260

gtggggactg gtctgatgag aaggattgtg gagattcaca tattcttccc ttctcgactc     4320

ctgggccctc cacgtgtctg cccaattact accgctgcag cagtgggacc tgcgtgatgg     4380

acacctgggt gtgcgacggg taccgagatt gtgcagatgg ctctgacgag gaagcctgcc     4440

ccttgcttgc aaacgtcact gctgcctcca ctcccaccca acttgggcga tgtgaccgat     4500

ttgagttcga atgccaccaa ccgaagacgt gtattcccaa ctggaagcgc tgtgacggcc     4560

accaagattg ccaggatggc cgggacgagg ccaattgccc cacacacagc accttgactt     4620

gcatgagcag ggagttccag tgcgaggacg gggaggcctg cattgtgctc tcggagcgct     4680

gcgacggctt cctggactgc tcggacgaga gcgatgaaaa ggcctgcagt gatgagttga     4740

ctgtgtacaa agtacagaat cttcagtgga cagctgactt ctctggggat gtgactttga     4800

cctggatgag gcccaaaaaa atgccctctg cttcttgtgt atataatgtc tactacaggg     4860

tggttggaga gagcatatgg aagactctgg agacccacag caataagaca aacactgtat     4920

taaaagtctt gaaaccagat accacgtatc aggttaaagt acaggttcag tgtctcagca     4980

aggcacacaa caccaatgac tttgtgaccc tgaggacccc agagggattg ccagatgccc     5040

ctcgaaatct ccagctgtca ctccccaggg aagcagaagg tgtgattgta ggccactggg     5100

ctcctcccat ccacacccat ggcctcatcc gtgagtacat tgtagaatac agcaggagtg     5160

gttccaagat gtgggcctcc cagagggctg ctagtaactt tacagaaatc aagaacttat     5220

tggtcaacac tctatacacc gtcagagtgg ctgcggtgac tagtcgtgga ataggaaact     5280

ggagcgattc taaatccatt accaccataa aaggaaaagt gatcccacca ccagatatcc     5340

acattgacag ctatggtgaa aattatctaa gcttcaccct gaccatggag agtgatatca     5400

aggtgaatgg ctatgtggtg aaccttttct gggcatttga cacccacaag caagagagga     5460

gaactttgaa cttccgagga agcatattgt cacacaaagt tggcaatctg acagctcata     5520

catcctatga gatttctgcc tgggccaaga ctgacttggg ggatagccct ctggcatttg     5580

agcatgttat gaccagaggg gttcgcccac ctgcacctag cctcaaggcc aaagccatca     5640

accagactgc agtggaatgt acctggaccg gcccccggaa tgtggtttat ggtattttct     5700

atgccacgtc ctttcttgac ctctatcgca acccgaagag cttgactact tcactccaca     5760

acaagacggt cattgtcagt aaggatgagc agtatttgtt tctggtccgt gtagtggtac     5820

cctaccaggg gccatcctct gactacgttg tagtgaagat gatcccggac agcaggcttc     5880

caccccgtca cctgcatgtg gttcatacgg gcaaaacctc cgtggtcatc aagtgggaat     5940

caccgtatga ctctcctgac caggacttgt tgtatgcaat tgcagtcaaa gatctcataa     6000

gaaagactga caggagctac aaagtaaaat cccgtaacag cactgtggaa tacaccctta     6060

acaagttgga gcctggcggg aaataccaca tcattgtcca actggggaac atgagcaaag     6120

attccagcat aaaaattacc acagtttcat tatcagcacc tgatgcctta aaaatcataa     6180

cagaaaatga tcatgttctt ctgttttgga aaagcctggc tttaaaggaa aagcatttta     6240

atgaaagcag gggctatgag atacacatgt ttgatagtgc catgaatatc acagcttacc     6300

ttgggaatac tactgacaat ttctttaaaa tttccaacct gaagatgggt cataattaca     6360

cgttcaccgt ccaagcaaga tgcctttttg gcaaccagat ctgtggggag cctgccatcc     6420

tgctgtacga tgagctgggg tctggtgcag atgcatctgc aacgcaggct gccagatcta     6480

cggatgttgc tgctgtggtg gtgcccatct tattcctgat actgctgagc ctgggggtgg     6540

ggtttgccat cctgtacacg aagcaccgga ggctgcagag cagcttcacc gccttcgcca     6600

acagccacta cagctccagg ctggggtccg caatcttctc ctctggggat gacctggggg     6660

aagatgatga agatgcccct atgataactg gattttcaga tgacgtcccc atggtgatag     6720

cctgaaagag ctttcctcac tagaaaccaa atggtgtaaa tattttattt gataaagata     6780

gttgatggtt tattttaaaa gatgcacttt gagttgcaat atgttatttt tatatgggcc     6840

aaaaacaaaa aacaaaaaaa aaaaaaagga aagaaaggaa tgaataaact ttgtagtaat     6900

caactgtgaa cttcaaacca ggttgatttt agtaacccaa ttgctttgat ttgacattaa     6960

tgtagtctta cagggctgtg cttgctgggc atgcttttac gtctgtgaga taatttcggt     7020

tcagtaaatt ggccaatctt tttatttttc taagacacag aaatgtattt aataaaaacc     7080

tcgagagagt gatgggtgga accccttctc cttgaaagtg tgtacagata ttccattttg     7140

tttggatata gtttatagga aagtgtgtgg atgtattatg gcggaaggtt tctttatgtt     7200

attttgttaa tttattggga ctctgtgtaa ggccaggctt tagtggtcat tagacaccac     7260

atgtgttatg agccccttac ccatagggtt gggggtggga agagaagcat atttttttgc     7320

cattccggaa gcaatccatt tttattcact tgtgtgtcat gtaatggtct ttggcaggag     7380

agagcactga gtcattgctg gagttcagtt caacagagct gcagcttggg aagccctgta     7440

agcccacagc ttcctctctt atattaattg atggaatttt actgtatgtg cctctgtaca     7500

agatgtagct ttgagagcta caaaatgata acactgcttt attacacact ggtttcattg     7560

tcattgcaaa aacttaccct ggttgtgggg gagagttcta gatctgtgcc atgatccata     7620

cactggctaa tagagtacat aatttttcca ttttccattt tttgttttta cttactactg     7680

aaggatctca gatgtaaaat tatgtatttg gtttgagatg gccacttatt gtccttaaaa     7740

atccatactg atatatgcag tcattttgaa ttggacagtg ccttctcttt ttttttctcc     7800

tcttcttcca tctccctcac ccatgccccc acccaatcta aagagacagt gctgtacatt     7860

ctcatagaga tagagaagat ctaaaaagtt gagactactc aatccagtta acaacagcag     7920

gagcactaga gtttgttcat ttattctctc tgtaaaacaa gctgtgcttt ttttcttctg     7980

cctttaaaat gccacccgtg tattcaaacc atggccactt gatacttatg tagaatccat     8040

cgtgggctga tgcaagccct ttatttaggc ttagtgttgt gggcaccaat gtcgagcatc     8100

gttgtgactt gtgctgtatg attctcactg aagaatttcc tttcagccaa gaagcagtga     8160

ggtctgggaa tattccaaag tcatgtctct gaatatgtgt ccttgacgtg caagctttgt     8220

aaaaccccat ccccgcttag gtgcgaggca tcaccttctc acaagtgttt agtttctttt     8280

aaccacaagt atcattcttg ggtgataata tagtttcatt ctacttaggg attgtttaga     8340

aaacaaagaa agagccaatt aaatttttta gtttttgaaa tttttattta tatgtatact     8400

tagatgagta ttttaagctg tcgaccttta gtttgccata cgggtaggac tgtatttcat     8460

gttaacaact ggtggtaatg ataagccttc ttctagcgta ttttctcttc tttcctgtca     8520

ctttcctaag tttttttttt taaagactgg aatttttttt ggctttatct tgtcttaccg     8580

tagagatttg ttcaaaactc taagccctac cacctcccct ttaataagct ctttaaatag     8640

ttgaatcatt aacaacctgg tgggaggcaa gtcatttaat tgaaccacta ggaagtgtat     8700

tttcttttct ttttctgcca actttttggt ggcatttgta aaagctgata taaaaggctc     8760

tgagatgtta ttttcagtta ttccataggc aagccttttt acagagcata tgtctccagt     8820

tggcagcttg agatatttcc gagcatccgg ttctagctac cagtgcctcc caatgcttag     8880

tgcacagtac tgtagactgg ccatcacccc tctccttgga aaatgccact gtgctgtttg     8940

aaaaaaagca gccttttagg gctagagtat tttatataaa cagaagagct aagttcctga     9000

agactaagct agatagctgc agctatatgt aaattgtata tttttatgaa cttttgaagc     9060

acacactcct gtttccctct gtgtagcttt gtggggattt catgtatata tgctgtctga     9120

aagaatccag aggttggagt gccaatagaa aatgaaaaca aatgccttgt actacaggca     9180

gcctctgaag gtgaccacat aactgtcttc actgtgacca atcggagtcc ctgcttgctt     9240

gtgaagaagg ggcttttgta ccttgttgga gatgccacct cagaagttca cactgtgcag     9300

gaaaaaggtt ttattctctc ctggcataca ttagaatgtc agatgcttgc atccatgtgg     9360

accacgatgg gcctctaaaa attggtgggc agggggtttg cttatgagtt ttctctggaa     9420

accgatttta ctcctggatg tattgaatgc cccttgagct ttatgagata cgagtccaca     9480

tggataaaat gttagagagt ggagttctac agaggattcc aggaagaggc catgtctgtg     9540

cagtcctagt tccagacagg tgagaagctc caggaactac tggctacctt gacaagctgg     9600

gtaaatagtt atcattctgg gtaactggtt gaaactctga cttttggaca agtaattcct     9660

ggggttctgt ctttggtagc atcaccaggg atatttgggt gggacagaca gaagacacac     9720

agctgcctgt tctctcctgc ccatcatgtt tggcccacta gatgaagctg tactcagcaa     9780

tttagggaat gtaacccttc tcagaactgg ccattttcag gggaagcttg ggagagcaat     9840

agtatggtga gccccttaga gatgagcgcc tactccttct tggcgaatgc tgccttcaga     9900

tgcttaccaa gtggtcactg catctagtaa gattatattt ccagtacact tccttagggc     9960

agaaacacca tcctatcagg tttggtcagt cccttcttca tgaagggagt catggggaat    10020

tcctgaaaat tttcttcctt ctgcagacag ttggatgagt cccttagaga aggcatccag    10080

agacataact aaactgaata tcatcccata ttgattttag gaattgactc taaaactctg    10140

tgcagaatct tgtgttggga ttgtatcttg acattcctgt tgtgttattt ttcttaactg    10200

gagtgtgtgc tgcctttcag gtacaatttt tgtgtaataa aagccagtgc attaagttta    10260

tatagactac tttctatgca agactgagat atggaataga taggaagaga tatgtactgc    10320

tgggtacatg gacagtaagt gtgttttcag atggagtacc agcaccgaaa atgggttgag    10380

ggaggatggg ttgtatgtat gtttctgccc actaattttg agcagccata ttatgaatta    10440

aatcgtcaca gccaagtaat aacccaagaa tggtatgagt ttcatgtgta atagctcaaa    10500

tggaataagc atgaatgctg gagtggacca ttatcctcaa atattctatg tcacttctca    10560

tttaaagact cttgttatga actattagaa actttaggca aaatcaaaag tatttgcggc    10620

aaaataaagg cctattctac tcttatttaa agtgaaacac tgtatacttg tttctctcca    10680

aagcgaaatt aagtatttat aatttcaatt gcctcgataa gtttccaagt cactgaaatc    10740

tgctgaaggt tttactgtat tgttgcacaa ctttaagata atttttgtct caatgtcaac    10800

ttttttcact gaataaaaat ttaactgggt caagaaaaca cctctttgaa aatccactgt    10860

ctctgtgtgt ctcgagctgt tctttagagc gcaataaaga tggctgacgc agtctccaaa    10920

cccc                                                                 10924


<210>  2
<211>  2208
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe 
1               5                   10                  15      


Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr 
            20                  25                  30          


Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe 
        35                  40                  45              


Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly 
    50                  55                  60                  


Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys 
65                  70                  75                  80  


Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val 
                85                  90                  95      


Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu 
            100                 105                 110         


Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala 
        115                 120                 125             


Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser 
    130                 135                 140                 


Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser 
145                 150                 155                 160 


Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg 
                165                 170                 175     


Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp 
            180                 185                 190         


Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp 
        195                 200                 205             


Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr 
225                 230                 235                 240 


Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp 
                245                 250                 255     


Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser 
            260                 265                 270         


Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu 
        275                 280                 285             


Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp 
    290                 295                 300                 


Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln 
305                 310                 315                 320 


Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg 
                325                 330                 335     


Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala 
            340                 345                 350         


Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn 
        355                 360                 365             


Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu 
    370                 375                 380                 


Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp 
385                 390                 395                 400 


Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg 
                405                 410                 415     


Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser 
            420                 425                 430         


Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly 
        435                 440                 445             


Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys 
    450                 455                 460                 


Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg 
465                 470                 475                 480 


Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser 
                485                 490                 495     


Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys 
            500                 505                 510         


Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala 
        515                 520                 525             


Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp 
    530                 535                 540                 


His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu 
545                 550                 555                 560 


Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe 
                565                 570                 575     


Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu 
            580                 585                 590         


Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His 
        595                 600                 605             


Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro 
    610                 615                 620                 


Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly 
625                 630                 635                 640 


Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro 
                645                 650                 655     


His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val 
            660                 665                 670         


Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe 
        675                 680                 685             


Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu 
    690                 695                 700                 


Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser 
705                 710                 715                 720 


Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys 
                725                 730                 735     


Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys 
            740                 745                 750         


Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser 
        755                 760                 765             


Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu 
    770                 775                 780                 


Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn 
785                 790                 795                 800 


Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys 
                805                 810                 815     


Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu 
            820                 825                 830         


Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp 
        835                 840                 845             


Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp 
    850                 855                 860                 


Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala 
865                 870                 875                 880 


Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly 
                885                 890                 895     


Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala 
            900                 905                 910         


Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val 
        915                 920                 925             


Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu 
    930                 935                 940                 


Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu 
945                 950                 955                 960 


Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp 
                965                 970                 975     


Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser 
            980                 985                 990         


Gln Met Glu Ile Leu Ala Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys 
        995                 1000                 1005             


Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro 
    1010                 1015                 1020             


Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg 
    1025                 1030                 1035             


Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser 
    1040                 1045                 1050             


Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn 
    1055                 1060                 1065             


Asn Thr  Cys Val Lys Glu Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr 
    1070                 1075                 1080             


Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp 
    1085                 1090                 1095             


Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro 
    1100                 1105                 1110             


Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser 
    1115                 1120                 1125             


Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp 
    1130                 1135                 1140             


Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys Glu Met  His Gln Cys 
    1145                 1150                 1155             


Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser 
    1160                 1165                 1170             


Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp 
    1175                 1180                 1185             


Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn 
    1190                 1195                 1200             


Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys 
    1205                 1210                 1215             


Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val 
    1220                 1225                 1230             


Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr 
    1235                 1240                 1245             


Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser 
    1250                 1255                 1260             


Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro Leu Cys  Thr His Phe 
    1265                 1270                 1275             


Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser 
    1280                 1285                 1290             


Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu 
    1295                 1300                 1305             


Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys 
    1310                 1315                 1320             


Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile 
    1325                 1330                 1335             


Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr 
    1340                 1345                 1350             


Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys 
    1355                 1360                 1365             


Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro 
    1370                 1375                 1380             


Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser 
    1385                 1390                 1395             


Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr 
    1400                 1405                 1410             


Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser 
    1415                 1420                 1425             


Gly Thr  Cys Val Met Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp 
    1430                 1435                 1440             


Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn 
    1445                 1450                 1455             


Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg 
    1460                 1465                 1470             


Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp 
    1475                 1480                 1485             


Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu 
    1490                 1495                 1500             


Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr Cys Met  Phe Gln Cys 
    1505                 1510                 1515             


Glu Asp  Gly Glu Ala Cys Ile  Val Leu Ser Glu Arg  Cys Asp Gly 
    1520                 1525                 1530             


Phe Leu  Asp Cys Ser Asp Glu  Ser Asp Glu Lys Ala  Cys Ser Asp 
    1535                 1540                 1545             


Glu Leu  Thr Val Tyr Lys Val  Gln Asn Leu Gln Trp  Thr Ala Asp 
    1550                 1555                 1560             


Phe Ser  Gly Asp Val Thr Leu  Thr Trp Met Arg Pro  Lys Lys Met 
    1565                 1570                 1575             


Pro Ser  Ala Ser Cys Val Tyr  Asn Val Tyr Tyr Arg  Val Val Gly 
    1580                 1585                 1590             


Glu Ser  Ile Trp Lys Thr Leu  Glu Thr His Ser Asn  Lys Thr Asn 
    1595                 1600                 1605             


Thr Val  Leu Lys Val Leu Lys  Pro Asp Thr Thr Tyr  Gln Val Lys 
    1610                 1615                 1620             


Val Gln  Val Gln Cys Leu Ser  Lys Ala His Asn Thr  Asn Asp Phe 
    1625                 1630                 1635             


Val Thr  Leu Arg Thr Pro Glu  Gly Leu Pro Asp Ala  Pro Arg Asn 
    1640                 1645                 1650             


Leu Gln  Leu Ser Leu Pro Arg  Glu Ala Glu Gly Val  Ile Val Gly 
    1655                 1660                 1665             


His Trp  Ala Pro Pro Ile His  Thr His Gly Leu Ile  Arg Glu Tyr 
    1670                 1675                 1680             


Ile Val  Glu Tyr Ser Arg Ser  Gly Ser Lys Met Trp  Ala Ser Gln 
    1685                 1690                 1695             


Arg Ala  Ala Ser Asn Phe Thr  Glu Ile Lys Asn Leu  Leu Val Asn 
    1700                 1705                 1710             


Thr Leu  Tyr Thr Val Arg Val  Ala Ala Val Thr Ser  Arg Gly Ile 
    1715                 1720                 1725             


Gly Asn  Trp Ser Asp Ser Lys  Ser Ile Thr Thr Ile  Lys Gly Val 
    1730                 1735                 1740             


Ile Pro  Pro Pro Asp Ile His  Ile Asp Ser Tyr Gly  Glu Asn Tyr 
    1745                 1750                 1755             


Leu Ser  Phe Thr Leu Thr Met  Glu Ser Asp Ile Lys  Val Asn Gly 
    1760                 1765                 1770             


Tyr Val  Val Asn Leu Phe Trp  Ala Phe Asp Thr His  Lys Gln Glu 
    1775                 1780                 1785             


Arg Arg  Thr Leu Asn Phe Arg  Gly Ser Ile Leu Ser  His Lys Val 
    1790                 1795                 1800             


Gly Asn  Leu Thr Ala His Thr  Ser Tyr Glu Ile Ser  Ala Trp Ala 
    1805                 1810                 1815             


Lys Thr  Asp Leu Gly Asp Ser  Pro Leu Ala Phe Glu  His Val Met 
    1820                 1825                 1830             


Thr Arg  Gly Val Arg Pro Pro  Ala Pro Ser Leu Lys  Ala Lys Ala 
    1835                 1840                 1845             


Ile Gln  Thr Ala Val Glu Cys  Thr Trp Thr Gly Pro  Arg Asn Val 
    1850                 1855                 1860             


Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe Leu Asp  Leu Tyr Arg 
    1865                 1870                 1875             


Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His Asn Lys  Thr Val Ile 
    1880                 1885                 1890             


Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu Val Arg  Val Val Val 
    1895                 1900                 1905             


Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val Val Val  Lys Met Ile 
    1910                 1915                 1920             


Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu His Val  Val His Thr 
    1925                 1930                 1935             


Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu Ser Pro  Tyr Asp Ser 
    1940                 1945                 1950             


Pro Asp  Gln Asp Leu Leu Tyr  Ala Ile Ala Val Lys  Asp Leu Ile 
    1955                 1960                 1965             


Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys Ser Arg  Asn Ser Thr 
    1970                 1975                 1980             


Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro Gly Gly  Lys Tyr His 
    1985                 1990                 1995             


Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys Asp Ser  Ser Ile Lys 
    2000                 2005                 2010             


Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp Ala Leu  Lys Ile Ile 
    2015                 2020                 2025             


Thr Glu  Asn Asp His Val Leu  Leu Phe Trp Lys Ser  Leu Ala Leu 
    2030                 2035                 2040             


Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly Tyr Glu  Ile His Met 
    2045                 2050                 2055             


Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr Leu Gly  Asn Thr Thr 
    2060                 2065                 2070             


Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys Met Gly  His Asn Tyr 
    2075                 2080                 2085             


Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe Gly Asn  Gln Ile Cys 
    2090                 2095                 2100             


Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu Leu Gly  Ser Gly Ala 
    2105                 2110                 2115             


Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser Thr Val  Ala Ala Val 
    2120                 2125                 2130             


Val Val  Pro Ile Leu Phe Leu  Ile Leu Leu Ser Leu  Gly Val Gly 
    2135                 2140                 2145             


Phe Ala  Ile Leu Tyr Thr Lys  His Arg Arg Leu Gln  Ser Ser Phe 
    2150                 2155                 2160             


Thr Ala  Phe Ala Asn Ser His  Tyr Ser Ser Arg Leu  Gly Ser Ala 
    2165                 2170                 2175             


Ile Phe  Ser Ser Gly Asp Asp  Leu Gly Glu Asp Asp  Glu Asp Ala 
    2180                 2185                 2190             


Pro Met  Ile Thr Gly Phe Ser  Asp Asp Val Pro Met  Val Ile Ala 
    2195                 2200                 2205             


<210>  3
<211>  3203
<212>  DNA
<213>  Homo sapiens

<400>  3
aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca       60

gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc      120

ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc      180

cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg      240

ccttcgtggt cctcctcgcc ctctgcagcc gggtaagcgc cgggagcccc cgctgcggcc      300

ggcggctgcc agggagggac tcggggccgg ccggggaggg cgtgcgcgcc gaccgagcgc      360

cgctgaccgc cctgtcctcc ctgcagccgg ccgtcggcca gaactgcagc gggccgtgcc      420

ggtgcccgga cgagccggcg ccgcgctgcc cggcgggcgt gagcctcgtg ctggacggct      480

gcggctgctg ccgcgtctgc gccaagcagc tgggcgagct gtgcaccgag cgcgacccat      540

gcgacccgca caagggccta ttctgtcact tcggctcccc ggccaaccgc aagatcggcg      600

tgtgcaccgg taagacccgc agcccccacc gctaggtgtc cggccgcctc ctccctcacg      660

cccacccgcc cgctggaaaa agaaaccgct cggactgagt ttctttctcc agctgctgcc      720

agcccgcccc ctgcagccca gatcccaact cgcatccctg acgctctgga tgtgagagtg      780

ccccaatgcc tgacctctgc atcccccacc cctctcttcc cttcctcttc tccagccaaa      840

gatggtgctc cctgcatctt cggtggtacg gtgtaccgca gcggagagtc cttccagagc      900

agctgcaagt accagtgcac gtgcctggac ggggcggtgg gctgcatgcc cctgtgcagc      960

atggacgttc gtctgcccag ccctgactgc cccttcccga ggagggtcaa gctgcccggg     1020

aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc aaaccgtggt tgggcctgcc     1080

ctcgcgggtg agtcgagtct tcctctaagt cagggtcgtg attctctccc agggagggag     1140

tcctaactgt gccgaccgaa cgggggaaat accttatcca ggcgttttac atggtgtttg     1200

tgtgctctgc tctcgcagct taccgactgg aagacacgtt tggcccagac ccaactatga     1260

ttagagccaa ctgcctggtc cagaccacag agtggagcgc ctgttccaag acctgtggga     1320

tgggcatctc cacccgggtt accaatgaca acgcctcctg caggctagag aagcagagcc     1380

gcctgtgcat ggtcaggcct tgcgaagctg acctggaaga gaacattaag gtacatgttc     1440

tgctcctatt aactattttt cacaggaaaa acagtggata ggacccaact tagggctctt     1500

gccacgcttg ttagtataag cccgttatct ccaaaactat ctaaccattg agctgttttg     1560

ctggaatgag agcttgtgta atagcaacca ccagttttcc actacgaaat cttccacagg     1620

gttagttaat tcaagacatt ccaagagagg ctctggctat ttttggacat agcaaatgag     1680

actcaaactt cctcccctca aaatataaac agaagtcaga caacagaaga ctaaaacaca     1740

gagggttgaa gaaagccact cctcttgtag agtcgctgat tttttttttt cctctctctt     1800

ttcccttgtc ttccttagaa gggcaaaaag tgcatccgta ctcccaaaat ctccaagcct     1860

atcaagtttg agctttctgg ctgcaccagc atgaagacat accgagctaa attctgtgga     1920

gtatgtaccg acggccgatg ctgcaccccc cacagaacca ccaccctgcc ggtggagttc     1980

aagtgccctg acggcgaggt catgaagaag aacatgatgt tcatcaagac ctgtgcctgc     2040

cattacaact gtcccggaga caatgacatc tttgaatcgc tgtactacag gaagatgtac     2100

ggagacatgg catgaagcca gagagtgaga gacattaact cattagactg gaacttgaac     2160

tgattcacat ctcatttttc cgtaaaaatg atttcagtag cacaagttat ttaaatctgt     2220

ttttctaact gggggaaaag attcccaccc aattcaaaac attgtgccat gtcaaacaaa     2280

tagtctatca accccagaca ctggtttgaa gaatgttaag acttgacagt ggaactacat     2340

tagtacacag caccagaatg tatattaagg tgtggcttta ggagcagtgg gagggtacca     2400

gcagaaaggt tagtatcatc agatagcatc ttatacgagt aatatgcctg ctatttgaag     2460

tgtaattgag aaggaaaatt ttagcgtgct cactgacctg cctgtagccc cagtgacagc     2520

taggatgtgc attctccagc catcaagaga ctgagtcaag ttgttcctta agtcagaaca     2580

gcagactcag ctctgacatt ctgattcgaa tgacactgtt caggaatcgg aatcctgtcg     2640

attagactgg acagcttgtg gcaagtgaat ttgcctgtaa caagccagat tttttaaaat     2700

ttatattgta aatattgtgt gtgtgtgtgt gtgtgtatat atatatatat gtacagttat     2760

ctaagttaat ttaaagttgt ttgtgccttt ttatttttgt ttttaatgct ttgatatttc     2820

aatgttagcc tcaatttctg aacaccatag gtagaatgta aagcttgtct gatcgttcaa     2880

agcatgaaat ggatacttat atggaaattc tgctcagata gaatgacagt ccgtcaaaac     2940

agattgtttg caaaggggag gcatcagtgt ccttggcagg ctgatttcta ggtaggaaat     3000

gtggtagcct cacttttaat gaacaaatgg cctttattaa aaactgagtg actctatata     3060

gctgatcagt tttttcacct ggaagcattt gtttctactt tgatatgact gtttttcgga     3120

cagtttattt gttgagagtg tgaccaaaag ttacatgttt gcacctttct agttgaaaat     3180

aaagtgtata ttttttctat aaa                                             3203


<210>  4
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys His Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  5
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Asn Cys Ser Gly Pro Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys His Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly 
65                  70                  75                  80  


Gly Thr Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Met Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys 
    130                 135                 140                 


Asp Gln Thr Val Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Thr Phe Gly Pro Asp Pro Thr Met Ile Arg Ala Asn Cys Leu Val Gln 
                165                 170                 175     


Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser 
            180                 185                 190         


Thr Arg Val Thr Asn Asp Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser 
        195                 200                 205             


Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile 
    210                 215                 220                 


Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile 
225                 230                 235                 240 


Lys Phe Glu Leu Ser Gly Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys 
                245                 250                 255     


Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr 
            260                 265                 270         


Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Val Met Lys 
        275                 280                 285             


Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro 
    290                 295                 300                 


Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly 
305                 310                 315                 320 


Asp Met Ala 
            


<210>  6
<211>  2418
<212>  DNA
<213>  Mus musculus

<400>  6
agttctttgg cgagccggct cccgggagcg tataaaagcc agcgccgccc gcctagtctc       60

acacagctct tctctccaag aagactcagc cagatccact ccagctccga ccccaggaga      120

ccgacctcct ccagacggca gcagccccag cccagccgac aaccccagac gccaccgcct      180

ggagcgtcca gacaccaacc tccgcccctg tccgaatcca ggctccggcc gcgcctctcg      240

tcgcctctgc accctgctgt gcatcctcct accgcgtccc gatcatgctc gcctccgtcg      300

caggtcccat cagcctcgcc ttggtgctcc tcgctctctg cacccggcct gctatgggcc      360

aggactgcag cgcgcaatgt cagtgcgcag ccgaagcagc gccgcactgc cccgccggcg      420

tgagcctggt gctggacggc tgcggctgct gccgcgtctg cgccaagcag ctgggagaac      480

tgtgtacgga gcgtgacccc tgcgacccac acaagggcct cttctgcgat ttcggctccc      540

ccgccaaccg caagatcgga gtgtgcactg ccaaagatgg tgcaccctgt gtcttcggtg      600

ggtcggtgta ccgcagcggt gagtccttcc aaagcagctg caaataccaa tgcacttgcc      660

tggatggggc cgtgggctgc gtgcccctgt gcagcatgga cgtgcgcctg cccagccctg      720

actgcccctt cccgagaagg gtcaagctgc ctgggaaatg ctgcgaggag tgggtgtgtg      780

acgagcccaa ggaccgcaca gcagttggcc ctgccctagc tgcctaccga ctggaagaca      840

catttggccc agacccaact atgatgcgag ccaactgcct ggtccagacc acagagtgga      900

gcgcctgttc taagacctgt gggatgggca tctccacccg agttaccaat gacaatacct      960

tctgcagact ggagaagcag agccgcctct gcatggtcag gccctgcgaa gctgacctgg     1020

aggaaaacat taagaagggc aaaaagtgca tccggacacc taaaatcgcc aagcctgtca     1080

agtttgagct ttctggctgc accagtgtga agacatacag ggctaagttc tgcggggtgt     1140

gcacagacgg ccgctgctgc acaccgcaca gaaccaccac tctgccagtg gagttcaaat     1200

gccccgatgg cgagatcatg aaaaagaata tgatgttcat caagacctgt gcctgccatt     1260

acaactgtcc tggggacaat gacatctttg agtccctgta ctacaggaag atgtacggag     1320

acatggcgta aagccaggaa gtaagggaca cgaactcatt agactataac ttgaactgag     1380

ttgcatctca ttttcttctg taaaaacaat tacagtagca cattaattta aatctgtgtt     1440

tttaactacc gtgggaggaa ctatcccacc aaagtgagaa cgttatgtca tggccataca     1500

agtagtctgt caacctcaga cactggtttc gagacagttt acacttgaca gttgttcatt     1560

agcgcacagt gccagaatgc acactgaggt gagtctcctg gaacagtgga gatgccagga     1620

gaaagaaaga caggtactag ctgaggttat tttaaaagca gcagtgtgcc tactttttgg     1680

agtgtaaccg gggagggaaa ttatagcatg cttgcagaca gacctgctct agcgagagct     1740

gagcatgtgt cctccactag atgaggctga gtccagctgt tctttaagaa cagcagtttc     1800

agctctgacc attctgattc cagtgacact tgtcaggagt cagagccttg tctgttagac     1860

tggacagctt gtggcaagta agtttgcctg taacaagcca gatttttatt gatattgtaa     1920

atattgtgga tatatatata tatatatata tatatatttg tacagttatc taagttaatt     1980

taaagtcatt tgtttttgtt ttaagtgctt ttgggatttt aaactgatag cctcaaactc     2040

caaacaccat aggtaggaca cgaagcttat ctgtgattca aaacaaagga gatactgcag     2100

tgggaattgt gacctgagtg actctctgtc agaacaaatg ctgtgcaggt gataaagcta     2160

tgtattggaa gtcagatttc tagtaggaaa tgtggtcaaa tccctgttgg tgaacaaatg     2220

gcctttatta agaaatggct ggctcagggt aaggtccgat tcctaccagg aagtgcttgc     2280

tgcttctttg attatgactg gtttggggtg gggggcagtt tatttgttga gagtgtgacc     2340

aaaagttaca tgtttgcacc tttctagttg aaaataaagt atatatatat tttttatatg     2400

aaaaaaaaaa aaaaaaaa                                                   2418


<210>  7
<211>  348
<212>  PRT
<213>  Mus musculus

<400>  7

Met Leu Ala Ser Val Ala Gly Pro Ile Ser Leu Ala Leu Val Leu Leu 
1               5                   10                  15      


Ala Leu Cys Thr Arg Pro Ala Thr Gly Gln Asp Cys Ser Ala Gln Cys 
            20                  25                  30          


Gln Cys Ala Ala Glu Ala Ala Pro His Cys Pro Ala Gly Val Ser Leu 
        35                  40                  45              


Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu Gly 
    50                  55                  60                  


Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu Phe 
65                  70                  75                  80  


Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr Ala 
                85                  90                  95      


Lys Asp Gly Ala Pro Cys Val Phe Gly Gly Ser Val Tyr Arg Ser Gly 
            100                 105                 110         


Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp Gly 
        115                 120                 125             


Ala Val Gly Cys Val Pro Leu Cys Ser Met Asp Val Arg Leu Pro Ser 
    130                 135                 140                 


Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys Cys 
145                 150                 155                 160 


Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Arg Thr Ala Val Gly Pro 
                165                 170                 175     


Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro Thr 
            180                 185                 190         


Met Met Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala Cys 
        195                 200                 205             


Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp Asn 
    210                 215                 220                 


Thr Phe Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg Pro 
225                 230                 235                 240 


Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys Ile 
                245                 250                 255     


Arg Thr Pro Lys Ile Ala Lys Pro Val Lys Phe Glu Leu Ser Gly Cys 
            260                 265                 270         


Thr Ser Val Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr Asp 
        275                 280                 285             


Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu Phe 
    290                 295                 300                 


Lys Cys Pro Asp Gly Glu Ile Met Lys Lys Asn Met Met Phe Ile Lys 
305                 310                 315                 320 


Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe Glu 
                325                 330                 335     


Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345             


<210>  8
<211>  323
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Asp Cys Ser Ala Gln Cys Gln Cys Ala Ala Glu Ala Ala Pro His 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Val Phe Gly 
65                  70                  75                  80  


Gly Ser Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Val Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys 
    130                 135                 140                 


Asp Arg Thr Ala Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Thr Phe Gly Pro Asp Pro Thr Met Met Arg Ala Asn Cys Leu Val Gln 
                165                 170                 175     


Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser 
            180                 185                 190         


Thr Arg Val Thr Asn Asp Asn Thr Phe Cys Arg Leu Glu Lys Gln Ser 
        195                 200                 205             


Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile 
    210                 215                 220                 


Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ala Lys Pro Val 
225                 230                 235                 240 


Lys Phe Glu Leu Ser Gly Cys Thr Ser Val Lys Thr Tyr Arg Ala Lys 
                245                 250                 255     


Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr 
            260                 265                 270         


Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Ile Met Lys 
        275                 280                 285             


Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro 
    290                 295                 300                 


Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly 
305                 310                 315                 320 


Asp Met Ala 
            


<210>  9
<211>  2338
<212>  DNA
<213>  Rattus norvegicus

<400>  9
ctccaagaag actcagccag acccactcca gctccgaccc taggagaccg acctcctcca       60

gacggcagca gccccagccc agtggacaac cccaggagcc accacctgga gcgtccggac      120

accaacctcc gccccgagac cgagtccagg ctccggccgc gcccctcgtc gcctctgcac      180

cccgctgtgc gtcctcctgc cgcgccccga ccatgctcgc ctccgtcgcg ggtcccgtta      240

gcctcgcctt ggtgctcctc ctctgcaccc ggcctgccac cggccaggac tgcagcgcgc      300

agtgtcagtg cgcacgtgaa gcggcgccgc gctgccccgc cggcgtgagc ctggtgctgg      360

acggctgcgg ctgctgccgc gtctgcgcca agcagctggg agaactgtgc acggagcgtg      420

atccctgcga cccacacaag ggtctcttct gcgacttcgg ctcccccgcc aaccgcaaga      480

ttggcgtgtg ccctgccaaa gatggtgcac cctgtgtctt cggtgggtcc gtgtaccgca      540

gcggcgagtc cttccaaagc agttgcaaat accagtgcac ttgcctggat ggggccgtgg      600

gctgtgtgcc cctgtgcagc atggacgtgc gcctgcccag ccctgactgc cccttcccga      660

gaagggtcaa gctgcccggg aaatgctgtg aggagtgggt gtgtgatgag cccaaggacc      720

gcacagtggt tggccctgcc ctagctgcct accgactgga agacacattt ggccctgacc      780

caactatgat gcgagccaac tgcctggtcc agaccacaga gtggagcgcc tgttctaaga      840

cctgtgggat gggcatctcc acccgggtta ccaatgacaa taccttctgc aggctggaga      900

agcagagtcg tctctgcatg gtcaggccct gtgaagctga cctagaggaa aacattaaga      960

agggcaaaaa gtgcatccgg acgcctaaaa ttgccaagcc tgtcaagttt gagctttctg     1020

gctgcaccag tgtgaagacc taccgggcta agttctgtgg ggtgtgcacg gacggccgct     1080

gctgcacacc gcacagaacc accacactgc cggtggagtt caagtgcccc gatggcgaga     1140

tcatgaaaaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccgggg     1200

acaatgacat ctttgagtcc ttgtactaca ggaagatgta tggagacatg gcgtaaagcc     1260

agggagtaag ggacacgaac tcatttagac tataacttga actgagttac atctcatttt     1320

cttctgtaaa aaaaacaaaa agggttacag tagcacatta atttaaatct gggttcctaa     1380

ctgctgtggg agaaaacacc ccaccgaagt gagaaccgtg tgtcattgtc atgcaaatag     1440

cctgtcaatc tcagacactg gtttcgagac agtttagact tgacagttgt tcactagcgc     1500

acagtgacag aacgcacact aaggtgagcc tcctggaaga gtggagatgc caggagaaag     1560

acaggtacta gctgaggtca ttttaaaagc agcgatatgc ctactttttg gagtgtgaca     1620

ggggagggac attatagctt gcttgcagac agacctgctc tagcaagagc tgggtgtgtg     1680

tcctccactc ggtgaggctg aagccagcta ttctttcagt aagaacagca gtttcagcgc     1740

tgacattctg attccagtga cactggtcgg gagtcagaac cttgtctatt agactggaca     1800

gcttgtggca agtgaatttg ccggtaacaa gccagatttt tatggatctt gtaaatattg     1860

tggataaata tatatatttg tacagttatc taagttaatt taaagacgtt tgtgcctatt     1920

gttcttgttt taagtgcttt tggaattttt aaactgatag cctcaaactc caaacaccat     1980

cgataggaca taaagcttgt ctgtgattca aaacaaagga gatactgcag tggaaactgt     2040

aacctgagtg actgtctgtc agaacatatg gtacgtagac ggtaaagcaa tggatcagaa     2100

gtcagatttc tagtaggaaa tgtaaaatca ctgttggcga acaaatggcc tttattaaga     2160

aatggcttgc tcagggtaac tggtcagatt tccacgagga agtgtttgct gcttctttga     2220

ctatgactgg tttgggaggc agtttatttg ttgagagtgt gaccaaaagt tacatgtttg     2280

cacctttcta gttgaaaata aagtatatat attttttata tgaaaaaaaa aaaaaaaa       2338


<210>  10
<211>  347
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Leu Ala Ser Val Ala Gly Pro Val Ser Leu Ala Leu Val Leu Leu 
1               5                   10                  15      


Leu Cys Thr Arg Pro Ala Thr Gly Gln Asp Cys Ser Ala Gln Cys Gln 
            20                  25                  30          


Cys Ala Ala Glu Ala Ala Pro Arg Cys Pro Ala Gly Val Ser Leu Val 
        35                  40                  45              


Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu Gly Glu 
    50                  55                  60                  


Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu Phe Cys 
65                  70                  75                  80  


Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr Ala Lys 
                85                  90                  95      


Asp Gly Ala Pro Cys Val Phe Gly Gly Ser Val Tyr Arg Ser Gly Glu 
            100                 105                 110         


Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp Gly Ala 
        115                 120                 125             


Val Gly Cys Val Pro Leu Cys Ser Met Asp Val Arg Leu Pro Ser Pro 
    130                 135                 140                 


Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys Cys Glu 
145                 150                 155                 160 


Glu Trp Val Cys Asp Glu Pro Lys Asp Arg Thr Val Val Gly Pro Ala 
                165                 170                 175     


Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro Thr Met 
            180                 185                 190         


Met Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala Cys Ser 
        195                 200                 205             


Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp Asn Thr 
    210                 215                 220                 


Phe Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg Pro Cys 
225                 230                 235                 240 


Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys Ile Arg 
                245                 250                 255     


Thr Pro Lys Ile Ala Lys Pro Val Lys Phe Glu Leu Ser Gly Cys Thr 
            260                 265                 270         


Ser Val Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr Asp Gly 
        275                 280                 285             


Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu Phe Lys 
    290                 295                 300                 


Cys Pro Asp Gly Glu Ile Met Lys Lys Asn Met Met Phe Ile Lys Thr 
305                 310                 315                 320 


Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe Glu Ser 
                325                 330                 335     


Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345         


<210>  11
<211>  323
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Gln Asp Cys Ser Ala Gln Cys Gln Cys Ala Ala Glu Ala Ala Pro Arg 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Val Phe Gly 
65                  70                  75                  80  


Gly Ser Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Val Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys 
    130                 135                 140                 


Asp Arg Thr Val Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Thr Phe Gly Pro Asp Pro Thr Met Met Arg Ala Asn Cys Leu Val Gln 
                165                 170                 175     


Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser 
            180                 185                 190         


Thr Arg Val Thr Asn Asp Asn Thr Phe Cys Arg Leu Glu Lys Gln Ser 
        195                 200                 205             


Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile 
    210                 215                 220                 


Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ala Lys Pro Val 
225                 230                 235                 240 


Lys Phe Glu Leu Ser Gly Cys Thr Ser Val Lys Thr Tyr Arg Ala Lys 
                245                 250                 255     


Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr 
            260                 265                 270         


Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Ile Met Lys 
        275                 280                 285             


Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro 
    290                 295                 300                 


Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly 
305                 310                 315                 320 


Asp Met Ala 
            


<210>  12
<211>  2330
<212>  DNA
<213>  Bos taurus

<400>  12
gaggcagcca gtgcgagtag gcagccagtg cgactcccac cgccggcgac ccacctcctc       60

cagtccgacg gcagccgccc cggccgacag ctcccgagac agcagcccgg cgctccccgg      120

cccacgcctc cggcccaaac ctgcgccgcc cgcccggcca gccgcctctc gccgcccgcc      180

gccctccgga cacagcgccc cgaccatgtc agccaccggc ctgggcccgg tccgctgcgc      240

cttcgtgctc ctgctcgccc tctgcagccg gcccgcctcc agccaggact gctgcagcgc      300

cccgtgccag tgccctgccg gcccggcgcc gcgctgcccc gccggcgtca gcttggtgct      360

ggacggctgc ggctgctgcg tgtgcgccaa gcagctgagc gagttgtgta ccgagcgcga      420

cccctgcgat ccgcacaagg gcctcttctg cgacttcggc tccccaacca accgcaagat      480

cggcgtgtgc accgctaaag atggtgcccc ctacattttc ggaggaactg tgtaccagag      540

cggagagtct ttccagagca gctgcaaata ccagtgcacg tgtctggacg ggtcggtggg      600

ctgcgtgccc ctatgcagcg tggacgtccg cctgcccagc cccgactgcc ccttcccacg      660

gagggtcaaa ctgcccggga aatgctgcga ggaatgggtg tcccgtgatg agaaggagca      720

caccgtggtc ggccctgcgc tggcagctta ccggctggaa gacacgtttg gcccagaccc      780

aaccatgatc cgagccaact gccaggtcca gaccacagag tggagtgcct attccaagac      840

ctgcggaatg ggcatctcca cccgggttac caatgacaac gcattctgca ggctggagaa      900

gcagagccgc ctctgcatgg tcaggccttg cgaagctgac ctggaggaga acattaagaa      960

aggcaaaaag tgcatccgga ctcccaaaat ctccaagcct atcaagtttc agctttctgg     1020

ctgcaccagc atgaagacat accgagctaa attcttcgga gtgtgcacag acgggcggtg     1080

ctgcaccccc cacagaacca ccacccttcc cgtggagttc aagtgtcctg atggggaggt     1140

catgaagaag agcatgatgt tcatcaagac ctgtgcctgc cattacaact gccccggaga     1200

caatgacatc ttcgagtcac tgtactacag gaagatgtat ggagacatgg cctaaagcca     1260

gagacagtga gacacgtgaa cattttaggc tgtcacttga atcgattcac atctcatttt     1320

tgtgtacacg tgatttcagt ggcacaagtt atttaaatct gtgcttctaa ctggggaaaa     1380

gaaaaattcc caccaaattc aaaatactgt gccatgtgat attcaaacga atagtccgtc     1440

aaccccagac actggtttga agaaattgag acttgatcat aggactgtat tagtgcacag     1500

caccagcatg tatgctagga gcagtgggag gaggccagta gaaagccttg tcatctttag     1560

gggtagtgat gtgactgcta tttggagtgt cactgaaaag gaaaacttta gcatgctcac     1620

tgatctgcct atagctccag caacagctcg gatgtgcgtt ctccagccat catgaggctg     1680

agtcaagttc gtctctaagt cagaacagca gattcagcta tgacattctg attcaaggac     1740

attgttcagg aatcagaatt ctgtctatta gactggacag cttgtggcaa gctaatttgc     1800

ctgtaacaag ccagattttt ttttattgat actgtaaata ttgtgtgtat atatatatat     1860

ttgtacagtt atctaagtta atttaaagtt gtttgtgcct ttttgtttat gtttttaatg     1920

ctttgatatt tcaagcgtta gcctcaattc tgaacaccat aggtaggacg gaaagcttgt     1980

ctgataattc aaagcatgaa atggatattc aaatagaatt tctgtgcagt tggagcaaca     2040

gtccatccaa acaggttgtt tgctgaaggt gaggcagtga tgtccttcaa agtctgatct     2100

gtaggttgga aacgtggtag cctcctttta acgaacaaat gacctttatt aaaaatgagt     2160

agctctgtat agctgattgg tttttccacc tggaagcatt tgtctctact ttgactatga     2220

ctgttttttg gacagattta tttgttgaga gtgtgaccaa aagttacatg tttgcacctt     2280

tctagttgaa aataaagtat atattttttc tataaaaaaa aaaaaaaaaa                2330


<210>  13
<211>  349
<212>  PRT
<213>  Bos taurus

<400>  13

Met Ser Ala Thr Gly Leu Gly Pro Val Arg Cys Ala Phe Val Leu Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Ser Ser Gln Asp Cys Ser Ala Pro 
            20                  25                  30          


Cys Gln Cys Pro Ala Gly Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Ser Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Val Phe Gly Gly Thr Val Tyr Gln Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ser Val Gly Cys Val Pro Leu Cys Ser Val Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Glu His Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Pro Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Phe Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Ser Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  14
<211>  323
<212>  PRT
<213>  Bos taurus

<400>  14

Gln Asp Cys Ser Ala Pro Cys Gln Cys Pro Ala Gly Pro Ala Pro Arg 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Ser Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Val Phe Gly 
65                  70                  75                  80  


Gly Thr Val Tyr Gln Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ser Val Gly Cys Val Pro Leu Cys Ser 
            100                 105                 110         


Val Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys 
    130                 135                 140                 


Glu His Thr Val Val Gly Pro Ala Leu Ala Ala Tyr Arg Pro Glu Asp 
145                 150                 155                 160 


Thr Phe Gly Pro Asp Pro Thr Met Ile Arg Ala Asn Cys Leu Val Gln 
                165                 170                 175     


Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser 
            180                 185                 190         


Thr Arg Val Thr Asn Asp Asn Ala Phe Cys Arg Leu Glu Lys Gln Ser 
        195                 200                 205             


Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile 
    210                 215                 220                 


Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile 
225                 230                 235                 240 


Lys Phe Glu Leu Ser Gly Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys 
                245                 250                 255     


Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr 
            260                 265                 270         


Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Val Met Lys 
        275                 280                 285             


Lys Ser Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro 
    290                 295                 300                 


Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly 
305                 310                 315                 320 


Asp Met Ala 
            


<210>  15
<211>  1598
<212>  DNA
<213>  Sus scrofa

<400>  15
gcacgagctg agaggaggca gtcagcccga ctcccaccgc cgacgaccca ccgccttcag       60

tccgacggca gccgccccgg ccgacagctc ccgagacagc cgcccggcgc gttccaggct      120

cccgcctccg gcccgaaccc gcgccgcccg ctcggcccgc cacgccaccc cagccccgcc      180

gccagccgcc cgcagcgccc cgaccatgtc cgccaccggc ctgagcccgg tccgctgcgc      240

cttcgtgctc ctgctcgccc tctgcagccg gcccgcctct ggccaggact gcagcggcca      300

atgccagtgc gcggccggga agcgccgcgc ttgccccgcc ggcgtcagct cgttgctgga      360

aggctgcggc tgctgccgat tgtgcgccaa gcacttgggt gacttgtgca cggagcgcgc      420

accctgcgac ccgcacaagg gcctcttctg tgacttcggc tccccggcca accgcaagat      480

cggagtgtgc acagccaaag attgtgcccc ctgcgtcttt ggaggaacgg tgtaccggag      540

cggagagtcc ttccagagca gctgcaaata ccagtgcact tgcctggacg gggccgtggg      600

ctgcgtgccc ctgtgcagca tggacgtccg cctgcccagc cccgactgcc ccttcccacg      660

gagggtcaag ctgcccggga aatgctgcga ggagtgggtg tgtgacgagc ccaaggacca      720

caccgtggtc gggcctgccc tggcggctta ccgactggaa gacacgtttg gcccagaccc      780

aactatgatg cgagccaact gcctggtcca gaccacagag tggagtgcct gttccaagac      840

ctgtgggatg ggcatctcca cccgggttac caatgacaac gcttcttgca gactggagaa      900

gcagagccgc ctctgcatgg tcaggccttg tgaagctgac ctggaagaga acattaagaa      960

gggcaaaaag tgcatccgta cccccaaaat ctccaagccc gtcaagtttg agctttccgg     1020

ctgcaccagt gtgaagacat accgggctaa gttctgcggg gtatgcacag acggccgctg     1080

ctgcacccct cacagaacca ccacccttcc tgtggagttc aagtgtcccg acggtgaggt     1140

catgaagaag agcatgatgt tcatcaagac ttgtgcctgc cattacaact gccccgggga     1200

caatgacatc ttcgagtccc tgtactacag gaagatgtat ggagacatgg cctaaagcca     1260

gagagagtga gaccatgaac acttgagact gtcactttga acttgattca catctcattt     1320

ttgcgtaaac atgattttca gtagcacagg ttatttaaag ccagagagag tgagacccat     1380

gaacacttga gactgtcact tgaactgatt cacatctcat ttttgcgtaa acatgatttc     1440

agtagcacag gttatttaaa tctgtttttc taatggggga caaaggaaaa ttcccaccaa     1500

cattcaaaat cgtgtgccat gtgacattca aaaaaagatc tatcaaaccc agacactggt     1560

ttgaagaaag ttcagacttg accgtgggga cggtatta                             1598


<210>  16
<211>  349
<212>  PRT
<213>  Sus scrofa

<400>  16

Met Ser Ala Thr Gly Leu Ser Pro Val Arg Cys Ala Phe Val Leu Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Ser Gly Gln Asp Cys Ser Gly Gln 
            20                  25                  30          


Cys Gln Cys Ala Ala Gly Lys Arg Arg Ala Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Ser Leu Leu Glu Gly Cys Gly Cys Cys Arg Leu Cys Ala Lys His Leu 
    50                  55                  60                  


Gly Asp Leu Cys Thr Glu Arg Ala Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Cys Ala Pro Cys Val Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Val Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp His Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Met Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Val Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Val Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Ser Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  17
<211>  323
<212>  PRT
<213>  Sus scrofa

<400>  17

Gln Asp Cys Ser Gly Gln Cys Gln Cys Ala Ala Gly Lys Arg Arg Ala 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Leu Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Val Phe Gly 
65                  70                  75                  80  


Gly Thr Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Val Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys 
    130                 135                 140                 


Asp His Thr Val Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Thr Phe Gly Pro Asp Pro Thr Met Met Arg Ala Asn Cys Leu Val Gln 
                165                 170                 175     


Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser 
            180                 185                 190         


Thr Arg Val Thr Asn Asp Asn Ala Phe Cys Arg Leu Glu Lys Gln Ser 
        195                 200                 205             


Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile 
    210                 215                 220                 


Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ser Lys Pro Val 
225                 230                 235                 240 


Lys Phe Glu Leu Ser Gly Cys Thr Ser Val Lys Thr Tyr Arg Ala Lys 
                245                 250                 255     


Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr 
            260                 265                 270         


Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Val Met Lys 
        275                 280                 285             


Lys Ser Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro 
    290                 295                 300                 


Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly 
305                 310                 315                 320 


Asp Met Ala 
            


<210>  18
<211>  2361
<212>  DNA
<213>  Xenopus laevis

<400>  18
tcccaagaca aggaaccaaa tacagcgaac gagggaaaag gaaagaggct tgagagaaaa       60

gaaactaagg gaactacaca atcgccaacg agatcacttt gagatcaaga cttgagagaa      120

cgacttttct ttggagtaga agagaactaa tctgctgctg tacaatgtct gcaggaaaag      180

tgacagctgt gctcctcttt gctctcttct gctgggtgtc tgatgcccag gagtgtaatg      240

gggaatgcca gtgcccaaat aaagtgcctg tgtgtgatcc tggagtcagc ctggtgcagg      300

atggctgtgg ctgctgcaag gtgtgctcca agcagctagg ggagctgtgc accgaaagag      360

atgtgtgcga cccacacaaa gggctcttct gtgacttcgg atccagagtg aacaggaaaa      420

ttggagtttg cactgccagg gaaggtgccc cttgtgtgtt cggaggcact gtgtatagaa      480

gtggggagtc tttccagagc agctgcaagt accaatgtac ttgtatcgat gggggtgtgg      540

gatgtgttcc actttgcagc atggacatcc gcctgcccag ccccgagtgc cccttcccac      600

gaagagtcaa actgcctggc aagtgctgtg aagaatgggt ctgtgatcaa cctcaagaga      660

gaaccttagt cggacctgct ttgcctgctt tcagaatgga agaaacctat ggtcctgatc      720

catccctaat ccgcgccaac tgcctagtac agactactga atggagtgct tgctcaaaga      780

cctgtggcat gggaatctcc accagggtca ctaatgacaa tgagcactgc agactggaga      840

aacagagcag actctgcatg gtcaggccct gtgaagctga cctagaagaa aacatcaaga      900

aagggaaaaa gtgcatccgt acaccaaaaa tttcaaaacc agtgaagttt gaattttccg      960

gctgcaccag cgtaaaaacc tacagagcca agttctgcgg tgtgtgcact gatggtcgtt     1020

gttgcactcc tcacagaacc gctaccctcc cagttgagtt caagtgccct gatggtgagg     1080

tcatgaagaa gaacatgatg ttcatcaaga catgcgcatg ccatttcaac tgtccaggag     1140

acaacgacat ctttgaggcc atgtactatc ggaaaatgta tggagacatg gcatagaggc     1200

agagaaacac acttcaaaga ctttttcact tgaaataact ttgcatctca ttgctaaaca     1260

taaatgtata gcacaagagc atatttaaat gtaattaatg aaaagtcttt attttgaaga     1320

cttaaaacgt taaatgaccc cagtcgttgg tttaaagaaa ttggcacaaa acaagccaca     1380

gccactgact tgagtgtaat gtgctgtcac tgtactccca aaattccggt acagtatagg     1440

gatgtccatc atgtgacctt tacctgaaac tgtcatgtca tgagagcatc acatattggc     1500

cacaggttgg acatatctgg taatctgcat tgcacccagt caagctactg gaaaaaaatt     1560

tctatttaca gtatatgatg aactggcgct atgtcagtga ccgctgaagt tttatagccc     1620

aactacctta ttgttctgaa gaaagccgtc cttgtgggac agctgtttta gaaaccccta     1680

agtacaaatt gggaggaact ttaactacgt ctgttacaag actggaaaga ttgtagcata     1740

tcaatgtaca tgctgtaatc ttgttttatt attattgtat ataatgtata tatatttttg     1800

tacagttatc taacttaact taaatttgtt tcgttcttca ttttttacaa tgctttaata     1860

tgtgtatgtt aaccgttttt atttttgttt gtttgcgata aatctatgct tatctgaaaa     1920

agaaaccatt caaagcacga aatagattct caaatagaaa ttgttctcag ttaaagagag     1980

ggacagtcca gtgactgctt acagttctgt ttattacgag ccatccggca gtgttgattg     2040

tactggaaac attgtattaa cttgacttcc tttaggtgcc agagaggtat ccagtgcatt     2100

tcacaagaaa gcaagggcaa cttctctggt acatatgggg tgaatgaaca aataaccagt     2160

tgagtgtata tcctgaaacg gatccatgta ttttgaacca gatcatctgt ttcctccttt     2220

gaccatgact gttctatttt caacagtttg ttacgtgttg agaagtgtga ccaaatggta     2280

catgtttgca cttttctaga tgaaaaataa aattacttta tttttatata aaaaaaaaaa     2340

aaaaaaaaaa aaaaaaaaaa a                                               2361


<210>  19
<211>  340
<212>  PRT
<213>  Xenopus laevis

<400>  19

Met Ser Ala Gly Lys Val Thr Ala Val Leu Leu Phe Ala Leu Phe Cys 
1               5                   10                  15      


Trp Val Ser Asp Ala Gln Glu Cys Asn Gly Glu Cys Gln Cys Pro Asn 
            20                  25                  30          


Lys Val Pro Val Cys Asp Pro Gly Val Ser Leu Val Gln Asp Gly Cys 
        35                  40                  45              


Gly Cys Cys Lys Val Cys Ser Lys Gln Leu Gly Glu Leu Cys Thr Glu 
    50                  55                  60                  


Arg Asp Val Cys Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser 
65                  70                  75                  80  


Arg Val Asn Arg Lys Ile Gly Val Cys Thr Ala Arg Glu Gly Ala Pro 
                85                  90                  95      


Cys Val Phe Gly Gly Thr Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser 
            100                 105                 110         


Ser Cys Lys Tyr Gln Cys Thr Cys Ile Asp Gly Gly Val Gly Cys Val 
        115                 120                 125             


Pro Leu Cys Ser Met Asp Ile Arg Leu Pro Ser Pro Glu Cys Pro Phe 
    130                 135                 140                 


Pro Arg Val Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp 
145                 150                 155                 160 


Gln Pro Gln Glu Arg Thr Leu Val Gly Pro Ala Leu Pro Ala Phe Arg 
                165                 170                 175     


Met Glu Glu Thr Tyr Gly Pro Asp Pro Ser Leu Ile Arg Ala Asn Cys 
            180                 185                 190         


Leu Val Gln Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met 
        195                 200                 205             


Gly Ile Ser Thr Arg Val Thr Asn Asp Asn Glu His Cys Arg Leu Glu 
    210                 215                 220                 


Lys Gln Ser Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu 
225                 230                 235                 240 


Glu Asn Ile Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ser 
                245                 250                 255     


Lys Val Lys Phe Glu Phe Ser Gly Cys Thr Ser Val Lys Thr Arg Ala 
            260                 265                 270         


Lys Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg 
        275                 280                 285             


Thr Ala Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Val Met 
    290                 295                 300                 


Lys Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Phe Asn Cys 
305                 310                 315                 320 


Pro Gly Asp Asn Asp Ile Phe Glu Ala Met Tyr Tyr Arg Lys Met Tyr 
                325                 330                 335     


Gly Asp Met Ala 
            340 


<210>  20
<211>  322
<212>  PRT
<213>  Xenopus laevis

<400>  20

Gln Glu Cys Asn Gly Glu Cys Gln Cys Pro Asn Lys Val Pro Val Cys 
1               5                   10                  15      


Asp Pro Gly Val Ser Leu Val Gln Asp Gly Cys Gly Cys Cys Lys Val 
            20                  25                  30          


Cys Ser Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Val Cys Asp 
        35                  40                  45              


Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Arg Val Asn Arg Lys 
    50                  55                  60                  


Ile Gly Val Cys Thr Ala Arg Glu Gly Ala Pro Cys Val Phe Gly Gly 
65                  70                  75                  80  


Thr Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln 
                85                  90                  95      


Cys Thr Cys Ile Asp Gly Gly Val Gly Cys Val Pro Leu Cys Ser Met 
            100                 105                 110         


Asp Ile Arg Leu Pro Ser Pro Glu Cys Pro Phe Pro Arg Arg Val Lys 
        115                 120                 125             


Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Gln Pro Gln Glu 
    130                 135                 140                 


Arg Thr Leu Val Gly Pro Ala Leu Pro Ala Phe Arg Met Glu Glu Thr 
145                 150                 155                 160 


Tyr Gly Pro Asp Pro Ser Leu Ile Arg Ala Asn Cys Leu Val Gln Thr 
                165                 170                 175     


Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr 
            180                 185                 190         


Arg Val Thr Asn Asp Asn Glu His Cys Arg Leu Glu Lys Gln Ser Arg 
        195                 200                 205             


Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys 
    210                 215                 220                 


Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ser Lys Pro Val Lys 
225                 230                 235                 240 


Phe Glu Phe Ser Gly Cys Thr Ser Val Lys Thr Tyr Arg Ala Lys Phe 
                245                 250                 255     


Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr Ala 
            260                 265                 270         


Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys 
        275                 280                 285             


Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Phe Asn Cys Pro Gly 
    290                 295                 300                 


Asp Asn Asp Ile Phe Glu Ala Met Tyr Tyr Arg Lys Met Tyr Gly Asp 
305                 310                 315                 320 


Met Ala 
        


<210>  21
<211>  2119
<212>  DNA
<213>  Danio rerio

<400>  21
gtcactcgac tcggctcagc ctaaacttct taccaaagct aaactctagc tttcactcaa       60

cacgatcagg aggaactgga ttcaaagact acacaacgag atcgacttga tcaaatctga      120

agagaagact ttgtaggatc tcaaaagaag atttttcttt ttgctacaaa ctttaaagaa      180

gtcatcatgt tttctggaat gactcaaagt gtgattgctc tgctgttcct gactttctta      240

agatgggctg tggctcaaga gtgcagtgga caatgccact gccctgaagt gccgccccag      300

tgttcacctg gtgtaagcct agttctggac acctgtgggt gctgccgggt gtgtgccaag      360

cagctgggcg agctgtgcac agaacgagat gtttgcgacc cccacaaagg tctttactgt      420

gactacggct ccccaagtaa ccgtcgtatt ggtgtctgca cagccagaga tggtgccact      480

tgtgtgtttg gtggaatggt gtaccgcagt ggagagtctt tccagagcag ttgtaaatac      540

cagtgcacgt gtctggacgg tgctgtaggt tgcgtgcccc tctgtggaat ggacatcagg      600

ctccccagcc cagactgccc aatgccccgc agggtgaaag tgcctgggaa gtgctgcgag      660

gagtgggtgt gtgactcccc tcgtcaaaac acctttgtgg gatcagcttt agcagcttac      720

agagaggagg agacatacgg tcccgatccc tccatgatga gagagaactg cctggttcag      780

actacagaat ggagcgcatg ctcaaaaacc tgtggcttgg gaatctctac tcgtgtgacc      840

aatgacaacc gtgagtgccg ccttgagaag cagtctcgcc tttgcatggt ccgcccttgc      900

gagtcacacc tggaggagaa aataaggaaa gggaaaaagt gcatccgcac accacgagtc      960

tccaaaccca tgaagtttga gatttccggc tgtaccacta ccaagtctta cagacccaag     1020

ttctgcggcg tttgcacaga tggtcgctgt tgcactcctc acagaaccgc caccttgccc     1080

atggagttca agtgccccga tggccaagtc atgaagaagc agatgatgtt catcaagacc     1140

tgcgcatgcc actacaactg ccctggggag aacgacatct ttgaatccat gtactacaag     1200

aagatggttg gcgacatggc gtgaaaagtc atgacctgac aaggagttcc atgcagtgac     1260

tgtccacttg aattgaacag atatccatct catatctcag cacaaattac ttgtttgtct     1320

ttttatggtt tgttgctttc attttacgtc tttttgcgtg tatgtgtttg catcttgttg     1380

gtggactctg gatttctatg ctgtatgtgt attcatttgt catggtggat gtctaagcct     1440

agggggtggg gatcgtaaaa tgaccgggcc ctgttcggac gcccctaaaa aacaatactg     1500

cactatagtc cgatgctgtg acgcccaatg tcactgattg gcagatgacg ccaagcccct     1560

cctctaaact gtggtgagca gattcagatt ctgagagcaa aaatagtaag aaatggatgg     1620

cagctttaac cccagaagct aatcgcctca ccaagctaag aaggcggaaa aaagagacag     1680

agagaaattg atgtgctctt atgtttagtt gatattgtca gctcagagtt tgattgagct     1740

gatccaagac atgaagtttg gccaagaact atgaaggtta atatagcact gagtgtttga     1800

ctgtctggcc cctcctgttg ggaaagagcc agtatccctg tcaaaaagac tggatgaatt     1860

gtagcttcat tcttttttat gacaatatct atttttgaaa gctgtaaata atgtacatat     1920

tttgtacagc ttaagttaat ttaaattgaa agcattttgt cttcttattt ccttgcttcg     1980

tcatgtttaa tgatagcttc atgtgctgac ttgactattc ttggtacagc ttgtccaata     2040

ttttattgag aagtgtgacc aaaatgttac atgttttcac ttttgtagtt tacaataaaa     2100

tattatattt ttatacaaa                                                  2119


<210>  22
<211>  345
<212>  PRT
<213>  Danio rerio

<400>  22

Met Phe Ser Gly Met Thr Gln Ser Val Ile Ala Leu Leu Phe Leu Thr 
1               5                   10                  15      


Phe Leu Arg Trp Ala Val Ala Gln Glu Cys Ser Gly Gln Cys His Cys 
            20                  25                  30          


Pro Glu Val Pro Pro Gln Cys Ser Pro Gly Val Ser Leu Val Leu Asp 
        35                  40                  45              


Thr Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu Gly Glu Leu Cys 
    50                  55                  60                  


Thr Glu Arg Asp Val Cys Asp Pro His Lys Gly Leu Tyr Cys Asp Tyr 
65                  70                  75                  80  


Gly Ser Pro Ser Asn Arg Arg Ile Gly Val Cys Thr Ala Arg Asp Gly 
                85                  90                  95      


Ala Thr Cys Val Phe Gly Gly Met Val Tyr Arg Ser Gly Glu Ser Phe 
            100                 105                 110         


Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp Gly Ala Val Gly 
        115                 120                 125             


Cys Val Pro Leu Cys Gly Met Asp Ile Arg Leu Pro Ser Pro Asp Cys 
    130                 135                 140                 


Pro Met Pro Arg Arg Val Lys Val Pro Gly Lys Cys Cys Glu Glu Trp 
145                 150                 155                 160 


Val Cys Asp Ser Pro Arg Gln Asn Thr Phe Val Gly Ser Ala Leu Ala 
                165                 170                 175     


Ala Tyr Arg Glu Glu Glu Thr Tyr Gly Pro Asp Pro Ser Met Met Arg 
            180                 185                 190         


Glu Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr 
        195                 200                 205             


Cys Gly Leu Gly Ile Ser Thr Arg Val Thr Asn Asp Asn Arg Glu Cys 
    210                 215                 220                 


Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg Pro Cys Glu Ser 
225                 230                 235                 240 


His Leu Glu Glu Lys Ile Arg Lys Gly Lys Lys Cys Ile Arg Thr Pro 
                245                 250                 255     


Arg Val Ser Lys Pro Met Lys Phe Glu Ile Ser Gly Cys Thr Thr Thr 
            260                 265                 270         


Lys Ser Tyr Arg Pro Lys Phe Cys Gly Val Cys Thr Asp Gly Arg Cys 
        275                 280                 285             


Cys Thr Pro His Arg Thr Ala Thr Leu Pro Met Glu Phe Lys Cys Pro 
    290                 295                 300                 


Asp Gly Gln Val Met Lys Lys Gln Met Met Phe Ile Lys Thr Cys Ala 
305                 310                 315                 320 


Cys His Tyr Asn Cys Pro Gly Glu Asn Asp Ile Phe Glu Ser Met Tyr 
                325                 330                 335     


Tyr Lys Lys Met Val Gly Asp Met Ala 
            340                 345 


<210>  23
<211>  322
<212>  PRT
<213>  Danio rerio

<400>  23

Gln Glu Cys Ser Gly Gln Cys His Cys Pro Glu Val Pro Pro Gln Cys 
1               5                   10                  15      


Ser Pro Gly Val Ser Leu Val Leu Asp Thr Cys Gly Cys Cys Arg Val 
            20                  25                  30          


Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Val Cys Asp 
        35                  40                  45              


Pro His Lys Gly Leu Tyr Cys Asp Tyr Gly Ser Pro Ser Asn Arg Arg 
    50                  55                  60                  


Ile Gly Val Cys Thr Ala Arg Asp Gly Ala Thr Cys Val Phe Gly Gly 
65                  70                  75                  80  


Met Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln 
                85                  90                  95      


Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Val Pro Leu Cys Gly Met 
            100                 105                 110         


Asp Ile Arg Leu Pro Ser Pro Asp Cys Pro Met Pro Arg Arg Val Lys 
        115                 120                 125             


Val Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Ser Pro Arg Gln 
    130                 135                 140                 


Asn Thr Phe Val Gly Ser Ala Leu Ala Ala Tyr Arg Glu Glu Glu Thr 
145                 150                 155                 160 


Tyr Gly Pro Asp Pro Ser Met Met Arg Glu Asn Cys Leu Val Gln Thr 
                165                 170                 175     


Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Leu Gly Ile Ser Thr 
            180                 185                 190         


Arg Val Thr Asn Asp Asn Arg Glu Cys Arg Leu Glu Lys Gln Ser Arg 
        195                 200                 205             


Leu Cys Met Val Arg Pro Cys Glu Ser His Leu Glu Glu Lys Ile Arg 
    210                 215                 220                 


Lys Gly Lys Lys Cys Ile Arg Thr Pro Arg Val Ser Lys Pro Met Lys 
225                 230                 235                 240 


Phe Glu Ile Ser Gly Cys Thr Thr Thr Lys Ser Tyr Arg Pro Lys Phe 
                245                 250                 255     


Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr Ala 
            260                 265                 270         


Thr Leu Pro Met Glu Phe Lys Cys Pro Asp Gly Gln Val Met Lys Lys 
        275                 280                 285             


Gln Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly 
    290                 295                 300                 


Glu Asn Asp Ile Phe Glu Ser Met Tyr Tyr Lys Lys Met Val Gly Asp 
305                 310                 315                 320 


Met Ala 
        


<210>  24
<211>  212
<212>  DNA
<213>  Homo sapiens

<400>  24
cttaccgact ggaagacacg tttggcccag acccaactat gattagagcc aactgcctgg       60

tccagaccac agagtggagc gcctgttcca agacctgtgg gatgggcatc tccacccggg      120

ttaccaatga caacgcctcc tgcaggctag agaagcagag ccgcctgtgc atggtcaggc      180

cttgcgaagc tgacctggaa gagaacatta ag                                    212


<210>  25
<211>  1385
<212>  DNA
<213>  Homo sapiens

<400>  25
aagggcaaaa agtgcatccg tactcccaaa atctccaagc ctatcaagtt tgagctttct       60

ggctgcacca gcatgaagac ataccgagct aaattctgtg gagtatgtac cgacggccga      120

tgctgcaccc cccacagaac caccaccctg ccggtggagt tcaagtgccc tgacggcgag      180

gtcatgaaga agaacatgat gttcatcaag acctgtgcct gccattacaa ctgtcccgga      240

gacaatgaca tctttgaatc gctgtactac aggaagatgt acggagacat ggcatgaagc      300

cagagagtga gagacattaa ctcattagac tggaacttga actgattcac atctcatttt      360

tccgtaaaaa tgatttcagt agcacaagtt atttaaatct gtttttctaa ctgggggaaa      420

agattcccac ccaattcaaa acattgtgcc atgtcaaaca aatagtctat caaccccaga      480

cactggtttg aagaatgtta agacttgaca gtggaactac attagtacac agcaccagaa      540

tgtatattaa ggtgtggctt taggagcagt gggagggtac cagcagaaag gttagtatca      600

tcagatagca tcttatacga gtaatatgcc tgctatttga agtgtaattg agaaggaaaa      660

ttttagcgtg ctcactgacc tgcctgtagc cccagtgaca gctaggatgt gcattctcca      720

gccatcaaga gactgagtca agttgttcct taagtcagaa cagcagactc agctctgaca      780

ttctgattcg aatgacactg ttcaggaatc ggaatcctgt cgattagact ggacagcttg      840

tggcaagtga atttgcctgt aacaagccag attttttaaa atttatattg taaatattgt      900

gtgtgtgtgt gtgtgtgtat atatatatat atgtacagtt atctaagtta atttaaagtt      960

gtttgtgcct ttttattttt gtttttaatg ctttgatatt tcaatgttag cctcaatttc     1020

tgaacaccat aggtagaatg taaagcttgt ctgatcgttc aaagcatgaa atggatactt     1080

atatggaaat tctgctcaga tagaatgaca gtccgtcaaa acagattgtt tgcaaagggg     1140

aggcatcagt gtccttggca ggctgatttc taggtaggaa atgtggtagc ctcactttta     1200

atgaacaaat ggcctttatt aaaaactgag tgactctata tagctgatca gttttttcac     1260

ctggaagcat ttgtttctac tttgatatga ctgtttttcg gacagtttat ttgttgagag     1320

tgtgaccaaa agttacatgt ttgcaccttt ctagttgaaa ataaagtgta tattttttct     1380

ataaa                                                                 1385


<210>  26
<211>  4247
<212>  DNA
<213>  Homo sapiens

<400>  26
gttccccaac tgctgtttta ttgtgctatt catgcctaga catcacatag ctagaaaggc       60

ccatcagacc cctcaggcca ctgctgttcc tgtcacacat tcctgcaaag gaccatgttg      120

ctaacttgaa aaaaattact attaattaca cttgcagttg ttgcttagta acatttatga      180

ttttgtgttt ctcgtgacag catgagcaga gatcattaaa aattaaactt acaaagctgc      240

taaagtggga agaaggagaa cttgaagcca caatttttgc acttgcttag aagccatcta      300

atctcaggtt tatatgctag atcttggggg aaacactgca tgtctctggt ttatattaaa      360

ccacatacag cacactactg acactgattt gtgtctggtg cagctggagt ttatcaccaa      420

gacataaaaa aaccttgacc ctgcagaatg gcctggaatt acaatcagat gggccacatg      480

gcatcccggt gaaagaaagc cctaaccagt tttctgtctt gtttctgctt tctccctaca      540

gttccaccag gtgagaagag tgatgaccat ccttttcctt actatggtta tttcatactt      600

tggttgcatg aaggctgccc ccatgaaaga agcaaacatc cgaggacaag gtggcttggc      660

ctacccaggt gtgcggaccc atgggactct ggagagcgtg aatgggccca aggcaggttc      720

aagaggcttg acatcattgg ctgacacttt cgaacacgtg atagaagagc tgttggatga      780

ggaccagaaa gttcggccca atgaagaaaa caataaggac gcagacttgt acacgtccag      840

ggtgatgctc agtagtcaag tgcctttgga gcctcctctt ctctttctgc tggaggaata      900

caaaaattac ctagatgctg caaacatgtc catgagggtc cggcgccact ctgaccctgc      960

ccgccgaggg gagctgagcg tgtgtgacag tattagtgag tgggtaacgg cggcagacaa     1020

aaagactgca gtggacatgt cgggcgggac ggtcacagtc cttgaaaagg tccctgtatc     1080

aaaaggccaa ctgaagcaat acttctacga gaccaagtgc aatcccatgg gttacacaaa     1140

agaaggctgc aggggcatag acaaaaggca ttggaactcc cagtgccgaa ctacccagtc     1200

gtacgtgcgg gcccttacca tggatagcaa aaagagaatt ggctggcgat tcataaggat     1260

agacacttct tgtgtatgta cattgaccat taaaagggga agatagtgga tttatgttgt     1320

atagattaga ttatattgag acaaaaatta tctatttgta tatatacata acagggtaaa     1380

ttattcagtt aagaaaaaaa taattttatg aactgcatgt ataaatgaag tttatacagt     1440

acagtggttc tacaatctat ttattggaca tgtccatgac cagaagggaa acagtcattt     1500

gcgcacaact taaaaagtct gcattacatt ccttgataat gttgtggttt gttgccgttg     1560

ccaagaactg aaaacataaa aagttaaaaa aaataataaa ttgcatgctg ctttaattgt     1620

gaattgataa taaactgtcc tctttcagaa aacagaaaaa aaacacacac acacacaaca     1680

aaaatttgaa ccaaaacatt ccgtttacat tttagacagt aagtatcttc gttcttgtta     1740

gtactatatc tgttttactg cttttaactt ctgatagcgt tggaattaaa acaatgtcaa     1800

ggtgctgttg tcattgcttt actggcttag gggatggggg atggggggta tatttttgtt     1860

tgttttgtgt ttttttttcg tttgtttgtt ttgtttttta gttcccacag ggagtagaga     1920

tggggaaaga attcctacaa tatatattct ggctgataaa agatacattt gtatgttgtg     1980

aagatgtttg caatatcgat cagatgacta gaaagtgaat aaaaattaag gcaactgaac     2040

aaaaaaatgc tcacactcca catcccgtga tgcacctccc aggccccgct cattctttgg     2100

gcgttggtca gagtaagctg cttttgacgg aaggacctat gtttgctcag aacacattct     2160

ttccccccct ccccctctgg tctcctcttt gttttgtttt aaggaagaaa aatcagttgc     2220

gcgttctgaa atattttacc actgctgtga acaagtgaac acattgtgtc acatcatgac     2280

actcgtataa gcatggagaa cagtgatttt tttttagaac agaaaacaac aaaaaataac     2340

cccaaaatga agattatttt ttatgaggag tgaacatttg ggtaaatcat ggctaagctt     2400

aaaaaaaact catggtgagg cttaacaatg tcttgtaagc aaaaggtaga gccctgtatc     2460

aacccagaaa cacctagatc agaacaggaa tccacattgc cagtgacatg agactgaaca     2520

gccaaatgga ggctatgtgg agttggcatt gcatttaccg gcagtgcggg aggaatttct     2580

gagtggccat cccaaggtct aggtggaggt ggggcatggt atttgagaca ttccaaaacg     2640

aaggcctctg aaggaccctt cagaggtggc tctggaatga catgtgtcaa gctgcttgga     2700

cctcgtgctt taagtgccta cattatctaa ctgtgctcaa gaggttctcg actggaggac     2760

cacactcaag ccgacttatg cccaccatcc cacctctgga taattttgca taaaattgga     2820

ttagcctgga gcaggttggg agccaaatgt ggcatttgtg atcatgagat tgatgcaatg     2880

agatagaaga tgtttgctac ctgaacactt attgctttga aactagactt gaggaaacca     2940

gggtttatct tttgagaact tttggtaagg gaaaagggaa caggaaaaga aaccccaaac     3000

tcaggccgaa tgatcaaggg gacccatagg aaatcttgtc cagagacaag acttcgggaa     3060

ggtgtctgga cattcagaac accaagactt gaaggtgcct tgctcaatgg aagaggccag     3120

gacagagctg acaaaatttt gctccccagt gaaggccaca gcaaccttct gcccatcctg     3180

tctgttcatg gagagggtcc ctgcctcacc tctgccattt tgggttagga gaagtcaagt     3240

tgggagcctg aaatagtggt tcttggaaaa atggatcccc agtgaaaact agagctctaa     3300

gcccattcag cccatttcac acctgaaaat gttagtgatc accacttgga ccagcatcct     3360

taagtatcag aaagccccaa gcaattgctg catcttagta gggtgaggga taagcaaaag     3420

aggatgttca ccataaccca ggaatgaaga taccatcagc aaagaatttc aatttgttca     3480

gtctttcatt tagagctagt ctttcacagt accatctgaa tacctctttg aaagaaggaa     3540

gactttacgt agtgtagatt tgttttgtgt tgtttgaaaa tattatcttt gtaattattt     3600

ttaatatgta aggaatgctt ggaatatctg ctatatgtca actttatgca gcttcctttt     3660

gagggacaaa tttaaaacaa acaacccccc atcacaaact taaaggattg caagggccag     3720

atctgttaag tggtttcata ggagacacat ccagcaattg tgtggtcagt ggctctttta     3780

cccaataaga tacatcacag tcacatgctt gatggtttat gttgacctaa gatttatttt     3840

gttaaaatct ctctctgttg tgttcgttct tgttctgttt tgttttgttt tttaaagtct     3900

tgctgtggtc tctttgtggc agaagtgttt catgcatggc agcaggcctg ttgctttttt     3960

atggcgattc ccattgaaaa tgtaagtaaa tgtctgtggc cttgttctct ctatggtaaa     4020

gatattattc accatgtaaa acaaaaaaca atatttattg tattttagta tatttatata     4080

attatgttat tgaaaaaaat tggcattaaa acttaaccgc atcagaacct attgtaaata     4140

caagttctat ttaagtgtac taattaacat ataatatatg ttttaaatat agaattttta     4200

atgtttttaa atatattttc aaagtacata aaaaaaaaaa aaaaaaa                   4247


<210>  27
<211>  4084
<212>  DNA
<213>  Homo sapiens

<400>  27
gtgtgtaatc cgggcgatag gagtccattc agcaccttgg acagagccaa cggatttgtc       60

cgaggtggcg gtacccccag gtagtcttct tggccccgct gtaaagccaa ccctgtgtcg      120

cccttaaaaa gcgtcttttc tgaggttcgg ctcacactga gatcggggct ggagagagag      180

tcagattttg gagcggagcg tttggaaagc gagccccagt ttggtcccct cattgagctc      240

gctgaagttg gcttcctagc ggtgtaggct ggaatagact cttggcaagc tccgggttgg      300

tatactgggt taactttggg aaatgcaagt gtttatctcc aggatctagc caccggggtg      360

gtgtaagccg caaagaagtt ccaccaggtg agaagagtga tgaccatcct tttccttact      420

atggttattt catactttgg ttgcatgaag gctgccccca tgaaagaagc aaacatccga      480

ggacaaggtg gcttggccta cccaggtgtg cggacccatg ggactctgga gagcgtgaat      540

gggcccaagg caggttcaag aggcttgaca tcattggctg acactttcga acacgtgata      600

gaagagctgt tggatgagga ccagaaagtt cggcccaatg aagaaaacaa taaggacgca      660

gacttgtaca cgtccagggt gatgctcagt agtcaagtgc ctttggagcc tcctcttctc      720

tttctgctgg aggaatacaa aaattaccta gatgctgcaa acatgtccat gagggtccgg      780

cgccactctg accctgcccg ccgaggggag ctgagcgtgt gtgacagtat tagtgagtgg      840

gtaacggcgg cagacaaaaa gactgcagtg gacatgtcgg gcgggacggt cacagtcctt      900

gaaaaggtcc ctgtatcaaa aggccaactg aagcaatact tctacgagac caagtgcaat      960

cccatgggtt acacaaaaga aggctgcagg ggcatagaca aaaggcattg gaactcccag     1020

tgccgaacta cccagtcgta cgtgcgggcc cttaccatgg atagcaaaaa gagaattggc     1080

tggcgattca taaggataga cacttcttgt gtatgtacat tgaccattaa aaggggaaga     1140

tagtggattt atgttgtata gattagatta tattgagaca aaaattatct atttgtatat     1200

atacataaca gggtaaatta ttcagttaag aaaaaaataa ttttatgaac tgcatgtata     1260

aatgaagttt atacagtaca gtggttctac aatctattta ttggacatgt ccatgaccag     1320

aagggaaaca gtcatttgcg cacaacttaa aaagtctgca ttacattcct tgataatgtt     1380

gtggtttgtt gccgttgcca agaactgaaa acataaaaag ttaaaaaaaa taataaattg     1440

catgctgctt taattgtgaa ttgataataa actgtcctct ttcagaaaac agaaaaaaaa     1500

cacacacaca cacaacaaaa atttgaacca aaacattccg tttacatttt agacagtaag     1560

tatcttcgtt cttgttagta ctatatctgt tttactgctt ttaacttctg atagcgttgg     1620

aattaaaaca atgtcaaggt gctgttgtca ttgctttact ggcttagggg atgggggatg     1680

gggggtatat ttttgtttgt tttgtgtttt tttttcgttt gtttgttttg ttttttagtt     1740

cccacaggga gtagagatgg ggaaagaatt cctacaatat atattctggc tgataaaaga     1800

tacatttgta tgttgtgaag atgtttgcaa tatcgatcag atgactagaa agtgaataaa     1860

aattaaggca actgaacaaa aaaatgctca cactccacat cccgtgatgc acctcccagg     1920

ccccgctcat tctttgggcg ttggtcagag taagctgctt ttgacggaag gacctatgtt     1980

tgctcagaac acattctttc cccccctccc cctctggtct cctctttgtt ttgttttaag     2040

gaagaaaaat cagttgcgcg ttctgaaata ttttaccact gctgtgaaca agtgaacaca     2100

ttgtgtcaca tcatgacact cgtataagca tggagaacag tgattttttt ttagaacaga     2160

aaacaacaaa aaataacccc aaaatgaaga ttatttttta tgaggagtga acatttgggt     2220

aaatcatggc taagcttaaa aaaaactcat ggtgaggctt aacaatgtct tgtaagcaaa     2280

aggtagagcc ctgtatcaac ccagaaacac ctagatcaga acaggaatcc acattgccag     2340

tgacatgaga ctgaacagcc aaatggaggc tatgtggagt tggcattgca tttaccggca     2400

gtgcgggagg aatttctgag tggccatccc aaggtctagg tggaggtggg gcatggtatt     2460

tgagacattc caaaacgaag gcctctgaag gacccttcag aggtggctct ggaatgacat     2520

gtgtcaagct gcttggacct cgtgctttaa gtgcctacat tatctaactg tgctcaagag     2580

gttctcgact ggaggaccac actcaagccg acttatgccc accatcccac ctctggataa     2640

ttttgcataa aattggatta gcctggagca ggttgggagc caaatgtggc atttgtgatc     2700

atgagattga tgcaatgaga tagaagatgt ttgctacctg aacacttatt gctttgaaac     2760

tagacttgag gaaaccaggg tttatctttt gagaactttt ggtaagggaa aagggaacag     2820

gaaaagaaac cccaaactca ggccgaatga tcaaggggac ccataggaaa tcttgtccag     2880

agacaagact tcgggaaggt gtctggacat tcagaacacc aagacttgaa ggtgccttgc     2940

tcaatggaag aggccaggac agagctgaca aaattttgct ccccagtgaa ggccacagca     3000

accttctgcc catcctgtct gttcatggag agggtccctg cctcacctct gccattttgg     3060

gttaggagaa gtcaagttgg gagcctgaaa tagtggttct tggaaaaatg gatccccagt     3120

gaaaactaga gctctaagcc cattcagccc atttcacacc tgaaaatgtt agtgatcacc     3180

acttggacca gcatccttaa gtatcagaaa gccccaagca attgctgcat cttagtaggg     3240

tgagggataa gcaaaagagg atgttcacca taacccagga atgaagatac catcagcaaa     3300

gaatttcaat ttgttcagtc tttcatttag agctagtctt tcacagtacc atctgaatac     3360

ctctttgaaa gaaggaagac tttacgtagt gtagatttgt tttgtgttgt ttgaaaatat     3420

tatctttgta attattttta atatgtaagg aatgcttgga atatctgcta tatgtcaact     3480

ttatgcagct tccttttgag ggacaaattt aaaacaaaca accccccatc acaaacttaa     3540

aggattgcaa gggccagatc tgttaagtgg tttcatagga gacacatcca gcaattgtgt     3600

ggtcagtggc tcttttaccc aataagatac atcacagtca catgcttgat ggtttatgtt     3660

gacctaagat ttattttgtt aaaatctctc tctgttgtgt tcgttcttgt tctgttttgt     3720

tttgtttttt aaagtcttgc tgtggtctct ttgtggcaga agtgtttcat gcatggcagc     3780

aggcctgttg cttttttatg gcgattccca ttgaaaatgt aagtaaatgt ctgtggcctt     3840

gttctctcta tggtaaagat attattcacc atgtaaaaca aaaaacaata tttattgtat     3900

tttagtatat ttatataatt atgttattga aaaaaattgg cattaaaact taaccgcatc     3960

agaacctatt gtaaatacaa gttctattta agtgtactaa ttaacatata atatatgttt     4020

taaatataga atttttaatg tttttaaata tattttcaaa gtacataaaa aaaaaaaaaa     4080

aaaa                                                                  4084


<210>  28
<211>  4084
<212>  DNA
<213>  Homo sapiens

<400>  28
gtgtgtaatc cgggcgatag gagtccattc agcaccttgg acagagccaa cggatttgtc       60

cgaggtggcg gtacccccag gtagtcttct tggccccgct gtaaagccaa ccctgtgtcg      120

cccttaaaaa gcgtcttttc tgaggttcgg ctcacactga gatcggggct ggagagagag      180

tcagattttg gagcggagcg tttggaaagc gagccccagt ttggtcccct cattgagctc      240

gctgaagttg gcttcctagc ggtgtaggct ggaatagact cttggcaagc tccgggttgg      300

tatactgggt taactttggg aaatgcaagt gtttatctcc aggatctagc caccggggtg      360

gtgtaagccg caaagaagtt ccaccaggtg agaagagtga tgaccatcct tttccttact      420

atggttattt catactttgg ttgcatgaag gctgccccca tgaaagaagc aaacatccga      480

ggacaaggtg gcttggccta cccaggtgtg cggacccatg ggactctgga gagcgtgaat      540

gggcccaagg caggttcaag aggcttgaca tcattggctg acactttcga acacgtgata      600

gaagagctgt tggatgagga ccagaaagtt cggcccaatg aagaaaacaa taaggacgca      660

gacttgtaca cgtccagggt gatgctcagt agtcaagtgc ctttggagcc tcctcttctc      720

tttctgctgg aggaatacaa aaattaccta gatgctgcaa acatgtccat gagggtccgg      780

cgccactctg accctgcccg ccgaggggag ctgagcgtgt gtgacagtat tagtgagtgg      840

gtaacggcgg cagacaaaaa gactgcagtg gacatgtcgg gcgggacggt cacagtcctt      900

gaaaaggtcc ctgtatcaaa aggccaactg aagcaatact tctacgagac caagtgcaat      960

cccatgggtt acacaaaaga aggctgcagg ggcatagaca aaaggcattg gaactcccag     1020

tgccgaacta cccagtcgta cgtgcgggcc cttaccatgg atagcaaaaa gagaattggc     1080

tggcgattca taaggataga cacttcttgt gtatgtacat tgaccattaa aaggggaaga     1140

tagtggattt atgttgtata gattagatta tattgagaca aaaattatct atttgtatat     1200

atacataaca gggtaaatta ttcagttaag aaaaaaataa ttttatgaac tgcatgtata     1260

aatgaagttt atacagtaca gtggttctac aatctattta ttggacatgt ccatgaccag     1320

aagggaaaca gtcatttgcg cacaacttaa aaagtctgca ttacattcct tgataatgtt     1380

gtggtttgtt gccgttgcca agaactgaaa acataaaaag ttaaaaaaaa taataaattg     1440

catgctgctt taattgtgaa ttgataataa actgtcctct ttcagaaaac agaaaaaaaa     1500

cacacacaca cacaacaaaa atttgaacca aaacattccg tttacatttt agacagtaag     1560

tatcttcgtt cttgttagta ctatatctgt tttactgctt ttaacttctg atagcgttgg     1620

aattaaaaca atgtcaaggt gctgttgtca ttgctttact ggcttagggg atgggggatg     1680

gggggtatat ttttgtttgt tttgtgtttt tttttcgttt gtttgttttg ttttttagtt     1740

cccacaggga gtagagatgg ggaaagaatt cctacaatat atattctggc tgataaaaga     1800

tacatttgta tgttgtgaag atgtttgcaa tatcgatcag atgactagaa agtgaataaa     1860

aattaaggca actgaacaaa aaaatgctca cactccacat cccgtgatgc acctcccagg     1920

ccccgctcat tctttgggcg ttggtcagag taagctgctt ttgacggaag gacctatgtt     1980

tgctcagaac acattctttc cccccctccc cctctggtct cctctttgtt ttgttttaag     2040

gaagaaaaat cagttgcgcg ttctgaaata ttttaccact gctgtgaaca agtgaacaca     2100

ttgtgtcaca tcatgacact cgtataagca tggagaacag tgattttttt ttagaacaga     2160

aaacaacaaa aaataacccc aaaatgaaga ttatttttta tgaggagtga acatttgggt     2220

aaatcatggc taagcttaaa aaaaactcat ggtgaggctt aacaatgtct tgtaagcaaa     2280

aggtagagcc ctgtatcaac ccagaaacac ctagatcaga acaggaatcc acattgccag     2340

tgacatgaga ctgaacagcc aaatggaggc tatgtggagt tggcattgca tttaccggca     2400

gtgcgggagg aatttctgag tggccatccc aaggtctagg tggaggtggg gcatggtatt     2460

tgagacattc caaaacgaag gcctctgaag gacccttcag aggtggctct ggaatgacat     2520

gtgtcaagct gcttggacct cgtgctttaa gtgcctacat tatctaactg tgctcaagag     2580

gttctcgact ggaggaccac actcaagccg acttatgccc accatcccac ctctggataa     2640

ttttgcataa aattggatta gcctggagca ggttgggagc caaatgtggc atttgtgatc     2700

atgagattga tgcaatgaga tagaagatgt ttgctacctg aacacttatt gctttgaaac     2760

tagacttgag gaaaccaggg tttatctttt gagaactttt ggtaagggaa aagggaacag     2820

gaaaagaaac cccaaactca ggccgaatga tcaaggggac ccataggaaa tcttgtccag     2880

agacaagact tcgggaaggt gtctggacat tcagaacacc aagacttgaa ggtgccttgc     2940

tcaatggaag aggccaggac agagctgaca aaattttgct ccccagtgaa ggccacagca     3000

accttctgcc catcctgtct gttcatggag agggtccctg cctcacctct gccattttgg     3060

gttaggagaa gtcaagttgg gagcctgaaa tagtggttct tggaaaaatg gatccccagt     3120

gaaaactaga gctctaagcc cattcagccc atttcacacc tgaaaatgtt agtgatcacc     3180

acttggacca gcatccttaa gtatcagaaa gccccaagca attgctgcat cttagtaggg     3240

tgagggataa gcaaaagagg atgttcacca taacccagga atgaagatac catcagcaaa     3300

gaatttcaat ttgttcagtc tttcatttag agctagtctt tcacagtacc atctgaatac     3360

ctctttgaaa gaaggaagac tttacgtagt gtagatttgt tttgtgttgt ttgaaaatat     3420

tatctttgta attattttta atatgtaagg aatgcttgga atatctgcta tatgtcaact     3480

ttatgcagct tccttttgag ggacaaattt aaaacaaaca accccccatc acaaacttaa     3540

aggattgcaa gggccagatc tgttaagtgg tttcatagga gacacatcca gcaattgtgt     3600

ggtcagtggc tcttttaccc aataagatac atcacagtca catgcttgat ggtttatgtt     3660

gacctaagat ttattttgtt aaaatctctc tctgttgtgt tcgttcttgt tctgttttgt     3720

tttgtttttt aaagtcttgc tgtggtctct ttgtggcaga agtgtttcat gcatggcagc     3780

aggcctgttg cttttttatg gcgattccca ttgaaaatgt aagtaaatgt ctgtggcctt     3840

gttctctcta tggtaaagat attattcacc atgtaaaaca aaaaacaata tttattgtat     3900

tttagtatat ttatataatt atgttattga aaaaaattgg cattaaaact taaccgcatc     3960

agaacctatt gtaaatacaa gttctattta agtgtactaa ttaacatata atatatgttt     4020

taaatataga atttttaatg tttttaaata tattttcaaa gtacataaaa aaaaaaaaaa     4080

aaaa                                                                  4084


<210>  29
<211>  3972
<212>  DNA
<213>  Homo sapiens

<400>  29
gctgccgccg ccgcgcccgg gcgcacccgc ccgctcgctg tcccgcgcac cccgtagcgc       60

ctcgggctcc cgggccggac agaggagcca gcccggtgcg cccctccacc tcctgctcgg      120

ggggctttaa tgagacaccc accgctgctg tggggccggc ggggagcagc accgcgacgg      180

ggaccggggc tgggcgctgg agccagaatc ggaaccacga tgtgactccg ccgccgggga      240

cccgtgaggt ttgtgtggac cccgagttcc accaggtgag aagagtgatg accatccttt      300

tccttactat ggttatttca tactttggtt gcatgaaggc tgcccccatg aaagaagcaa      360

acatccgagg acaaggtggc ttggcctacc caggtgtgcg gacccatggg actctggaga      420

gcgtgaatgg gcccaaggca ggttcaagag gcttgacatc attggctgac actttcgaac      480

acgtgataga agagctgttg gatgaggacc agaaagttcg gcccaatgaa gaaaacaata      540

aggacgcaga cttgtacacg tccagggtga tgctcagtag tcaagtgcct ttggagcctc      600

ctcttctctt tctgctggag gaatacaaaa attacctaga tgctgcaaac atgtccatga      660

gggtccggcg ccactctgac cctgcccgcc gaggggagct gagcgtgtgt gacagtatta      720

gtgagtgggt aacggcggca gacaaaaaga ctgcagtgga catgtcgggc gggacggtca      780

cagtccttga aaaggtccct gtatcaaaag gccaactgaa gcaatacttc tacgagacca      840

agtgcaatcc catgggttac acaaaagaag gctgcagggg catagacaaa aggcattgga      900

actcccagtg ccgaactacc cagtcgtacg tgcgggccct taccatggat agcaaaaaga      960

gaattggctg gcgattcata aggatagaca cttcttgtgt atgtacattg accattaaaa     1020

ggggaagata gtggatttat gttgtataga ttagattata ttgagacaaa aattatctat     1080

ttgtatatat acataacagg gtaaattatt cagttaagaa aaaaataatt ttatgaactg     1140

catgtataaa tgaagtttat acagtacagt ggttctacaa tctatttatt ggacatgtcc     1200

atgaccagaa gggaaacagt catttgcgca caacttaaaa agtctgcatt acattccttg     1260

ataatgttgt ggtttgttgc cgttgccaag aactgaaaac ataaaaagtt aaaaaaaata     1320

ataaattgca tgctgcttta attgtgaatt gataataaac tgtcctcttt cagaaaacag     1380

aaaaaaaaca cacacacaca caacaaaaat ttgaaccaaa acattccgtt tacattttag     1440

acagtaagta tcttcgttct tgttagtact atatctgttt tactgctttt aacttctgat     1500

agcgttggaa ttaaaacaat gtcaaggtgc tgttgtcatt gctttactgg cttaggggat     1560

gggggatggg gggtatattt ttgtttgttt tgtgtttttt tttcgtttgt ttgttttgtt     1620

ttttagttcc cacagggagt agagatgggg aaagaattcc tacaatatat attctggctg     1680

ataaaagata catttgtatg ttgtgaagat gtttgcaata tcgatcagat gactagaaag     1740

tgaataaaaa ttaaggcaac tgaacaaaaa aatgctcaca ctccacatcc cgtgatgcac     1800

ctcccaggcc ccgctcattc tttgggcgtt ggtcagagta agctgctttt gacggaagga     1860

cctatgtttg ctcagaacac attctttccc cccctccccc tctggtctcc tctttgtttt     1920

gttttaagga agaaaaatca gttgcgcgtt ctgaaatatt ttaccactgc tgtgaacaag     1980

tgaacacatt gtgtcacatc atgacactcg tataagcatg gagaacagtg attttttttt     2040

agaacagaaa acaacaaaaa ataaccccaa aatgaagatt attttttatg aggagtgaac     2100

atttgggtaa atcatggcta agcttaaaaa aaactcatgg tgaggcttaa caatgtcttg     2160

taagcaaaag gtagagccct gtatcaaccc agaaacacct agatcagaac aggaatccac     2220

attgccagtg acatgagact gaacagccaa atggaggcta tgtggagttg gcattgcatt     2280

taccggcagt gcgggaggaa tttctgagtg gccatcccaa ggtctaggtg gaggtggggc     2340

atggtatttg agacattcca aaacgaaggc ctctgaagga cccttcagag gtggctctgg     2400

aatgacatgt gtcaagctgc ttggacctcg tgctttaagt gcctacatta tctaactgtg     2460

ctcaagaggt tctcgactgg aggaccacac tcaagccgac ttatgcccac catcccacct     2520

ctggataatt ttgcataaaa ttggattagc ctggagcagg ttgggagcca aatgtggcat     2580

ttgtgatcat gagattgatg caatgagata gaagatgttt gctacctgaa cacttattgc     2640

tttgaaacta gacttgagga aaccagggtt tatcttttga gaacttttgg taagggaaaa     2700

gggaacagga aaagaaaccc caaactcagg ccgaatgatc aaggggaccc ataggaaatc     2760

ttgtccagag acaagacttc gggaaggtgt ctggacattc agaacaccaa gacttgaagg     2820

tgccttgctc aatggaagag gccaggacag agctgacaaa attttgctcc ccagtgaagg     2880

ccacagcaac cttctgccca tcctgtctgt tcatggagag ggtccctgcc tcacctctgc     2940

cattttgggt taggagaagt caagttggga gcctgaaata gtggttcttg gaaaaatgga     3000

tccccagtga aaactagagc tctaagccca ttcagcccat ttcacacctg aaaatgttag     3060

tgatcaccac ttggaccagc atccttaagt atcagaaagc cccaagcaat tgctgcatct     3120

tagtagggtg agggataagc aaaagaggat gttcaccata acccaggaat gaagatacca     3180

tcagcaaaga atttcaattt gttcagtctt tcatttagag ctagtctttc acagtaccat     3240

ctgaatacct ctttgaaaga aggaagactt tacgtagtgt agatttgttt tgtgttgttt     3300

gaaaatatta tctttgtaat tatttttaat atgtaaggaa tgcttggaat atctgctata     3360

tgtcaacttt atgcagcttc cttttgaggg acaaatttaa aacaaacaac cccccatcac     3420

aaacttaaag gattgcaagg gccagatctg ttaagtggtt tcataggaga cacatccagc     3480

aattgtgtgg tcagtggctc ttttacccaa taagatacat cacagtcaca tgcttgatgg     3540

tttatgttga cctaagattt attttgttaa aatctctctc tgttgtgttc gttcttgttc     3600

tgttttgttt tgttttttaa agtcttgctg tggtctcttt gtggcagaag tgtttcatgc     3660

atggcagcag gcctgttgct tttttatggc gattcccatt gaaaatgtaa gtaaatgtct     3720

gtggccttgt tctctctatg gtaaagatat tattcaccat gtaaaacaaa aaacaatatt     3780

tattgtattt tagtatattt atataattat gttattgaaa aaaattggca ttaaaactta     3840

accgcatcag aacctattgt aaatacaagt tctatttaag tgtactaatt aacatataat     3900

atatgtttta aatatagaat ttttaatgtt tttaaatata ttttcaaagt acataaaaaa     3960

aaaaaaaaaa aa                                                         3972


<210>  30
<211>  4016
<212>  DNA
<213>  Homo sapiens

<400>  30
ggctgctctc gctgccgctc cccccggcga actagcatga aatctccctg cctctgccga       60

gatcaaatgg agcttctcgc tgatggggtg cgagtattac ctccgccatg caatttccac      120

tatcaataat ttaacttctt tgctgcagaa cagaaggagt acataccggg caccaaagac      180

tcgcgccccc tccccccttt aattaagcga agggaacgtg aaaaaataat agagtgtggg      240

agttttgggg ccgaagtctt tcccggagca gctgccttga tggttacttt gacaagtagt      300

gactgaaaag ttccaccagg tgagaagagt gatgaccatc cttttcctta ctatggttat      360

ttcatacttt ggttgcatga aggctgcccc catgaaagaa gcaaacatcc gaggacaagg      420

tggcttggcc tacccaggtg tgcggaccca tgggactctg gagagcgtga atgggcccaa      480

ggcaggttca agaggcttga catcattggc tgacactttc gaacacgtga tagaagagct      540

gttggatgag gaccagaaag ttcggcccaa tgaagaaaac aataaggacg cagacttgta      600

cacgtccagg gtgatgctca gtagtcaagt gcctttggag cctcctcttc tctttctgct      660

ggaggaatac aaaaattacc tagatgctgc aaacatgtcc atgagggtcc ggcgccactc      720

tgaccctgcc cgccgagggg agctgagcgt gtgtgacagt attagtgagt gggtaacggc      780

ggcagacaaa aagactgcag tggacatgtc gggcgggacg gtcacagtcc ttgaaaaggt      840

ccctgtatca aaaggccaac tgaagcaata cttctacgag accaagtgca atcccatggg      900

ttacacaaaa gaaggctgca ggggcataga caaaaggcat tggaactccc agtgccgaac      960

tacccagtcg tacgtgcggg cccttaccat ggatagcaaa aagagaattg gctggcgatt     1020

cataaggata gacacttctt gtgtatgtac attgaccatt aaaaggggaa gatagtggat     1080

ttatgttgta tagattagat tatattgaga caaaaattat ctatttgtat atatacataa     1140

cagggtaaat tattcagtta agaaaaaaat aattttatga actgcatgta taaatgaagt     1200

ttatacagta cagtggttct acaatctatt tattggacat gtccatgacc agaagggaaa     1260

cagtcatttg cgcacaactt aaaaagtctg cattacattc cttgataatg ttgtggtttg     1320

ttgccgttgc caagaactga aaacataaaa agttaaaaaa aataataaat tgcatgctgc     1380

tttaattgtg aattgataat aaactgtcct ctttcagaaa acagaaaaaa aacacacaca     1440

cacacaacaa aaatttgaac caaaacattc cgtttacatt ttagacagta agtatcttcg     1500

ttcttgttag tactatatct gttttactgc ttttaacttc tgatagcgtt ggaattaaaa     1560

caatgtcaag gtgctgttgt cattgcttta ctggcttagg ggatggggga tggggggtat     1620

atttttgttt gttttgtgtt tttttttcgt ttgtttgttt tgttttttag ttcccacagg     1680

gagtagagat ggggaaagaa ttcctacaat atatattctg gctgataaaa gatacatttg     1740

tatgttgtga agatgtttgc aatatcgatc agatgactag aaagtgaata aaaattaagg     1800

caactgaaca aaaaaatgct cacactccac atcccgtgat gcacctccca ggccccgctc     1860

attctttggg cgttggtcag agtaagctgc ttttgacgga aggacctatg tttgctcaga     1920

acacattctt tccccccctc cccctctggt ctcctctttg ttttgtttta aggaagaaaa     1980

atcagttgcg cgttctgaaa tattttacca ctgctgtgaa caagtgaaca cattgtgtca     2040

catcatgaca ctcgtataag catggagaac agtgattttt ttttagaaca gaaaacaaca     2100

aaaaataacc ccaaaatgaa gattattttt tatgaggagt gaacatttgg gtaaatcatg     2160

gctaagctta aaaaaaactc atggtgaggc ttaacaatgt cttgtaagca aaaggtagag     2220

ccctgtatca acccagaaac acctagatca gaacaggaat ccacattgcc agtgacatga     2280

gactgaacag ccaaatggag gctatgtgga gttggcattg catttaccgg cagtgcggga     2340

ggaatttctg agtggccatc ccaaggtcta ggtggaggtg gggcatggta tttgagacat     2400

tccaaaacga aggcctctga aggacccttc agaggtggct ctggaatgac atgtgtcaag     2460

ctgcttggac ctcgtgcttt aagtgcctac attatctaac tgtgctcaag aggttctcga     2520

ctggaggacc acactcaagc cgacttatgc ccaccatccc acctctggat aattttgcat     2580

aaaattggat tagcctggag caggttggga gccaaatgtg gcatttgtga tcatgagatt     2640

gatgcaatga gatagaagat gtttgctacc tgaacactta ttgctttgaa actagacttg     2700

aggaaaccag ggtttatctt ttgagaactt ttggtaaggg aaaagggaac aggaaaagaa     2760

accccaaact caggccgaat gatcaagggg acccatagga aatcttgtcc agagacaaga     2820

cttcgggaag gtgtctggac attcagaaca ccaagacttg aaggtgcctt gctcaatgga     2880

agaggccagg acagagctga caaaattttg ctccccagtg aaggccacag caaccttctg     2940

cccatcctgt ctgttcatgg agagggtccc tgcctcacct ctgccatttt gggttaggag     3000

aagtcaagtt gggagcctga aatagtggtt cttggaaaaa tggatcccca gtgaaaacta     3060

gagctctaag cccattcagc ccatttcaca cctgaaaatg ttagtgatca ccacttggac     3120

cagcatcctt aagtatcaga aagccccaag caattgctgc atcttagtag ggtgagggat     3180

aagcaaaaga ggatgttcac cataacccag gaatgaagat accatcagca aagaatttca     3240

atttgttcag tctttcattt agagctagtc tttcacagta ccatctgaat acctctttga     3300

aagaaggaag actttacgta gtgtagattt gttttgtgtt gtttgaaaat attatctttg     3360

taattatttt taatatgtaa ggaatgcttg gaatatctgc tatatgtcaa ctttatgcag     3420

cttccttttg agggacaaat ttaaaacaaa caacccccca tcacaaactt aaaggattgc     3480

aagggccaga tctgttaagt ggtttcatag gagacacatc cagcaattgt gtggtcagtg     3540

gctcttttac ccaataagat acatcacagt cacatgcttg atggtttatg ttgacctaag     3600

atttattttg ttaaaatctc tctctgttgt gttcgttctt gttctgtttt gttttgtttt     3660

ttaaagtctt gctgtggtct ctttgtggca gaagtgtttc atgcatggca gcaggcctgt     3720

tgctttttta tggcgattcc cattgaaaat gtaagtaaat gtctgtggcc ttgttctctc     3780

tatggtaaag atattattca ccatgtaaaa caaaaaacaa tatttattgt attttagtat     3840

atttatataa ttatgttatt gaaaaaaatt ggcattaaaa cttaaccgca tcagaaccta     3900

ttgtaaatac aagttctatt taagtgtact aattaacata taatatatgt tttaaatata     3960

gaatttttaa tgtttttaaa tatattttca aagtacataa aaaaaaaaaa aaaaaa         4016


<210>  31
<211>  3958
<212>  DNA
<213>  Homo sapiens

<400>  31
agtggactta caagtccgaa gccaatgtag cttggaaaac ttgggaggcg gaattcctac       60

cgctgggaac tgaaagggtc tgcgacactc tcgggcaggc cgaacccaca tctctaccca      120

tcctgcgccc ctcttctgaa gcgccctcca gggaagttaa gagttttgac tttcggggag      180

tggttgggat gtacgtgggg gattcttgac tcgggttagt ctctggggat gcagagccgg      240

gaagaggaat ggttccacca ggtgagaaga gtgatgacca tccttttcct tactatggtt      300

atttcatact ttggttgcat gaaggctgcc cccatgaaag aagcaaacat ccgaggacaa      360

ggtggcttgg cctacccagg tgtgcggacc catgggactc tggagagcgt gaatgggccc      420

aaggcaggtt caagaggctt gacatcattg gctgacactt tcgaacacgt gatagaagag      480

ctgttggatg aggaccagaa agttcggccc aatgaagaaa acaataagga cgcagacttg      540

tacacgtcca gggtgatgct cagtagtcaa gtgcctttgg agcctcctct tctctttctg      600

ctggaggaat acaaaaatta cctagatgct gcaaacatgt ccatgagggt ccggcgccac      660

tctgaccctg cccgccgagg ggagctgagc gtgtgtgaca gtattagtga gtgggtaacg      720

gcggcagaca aaaagactgc agtggacatg tcgggcggga cggtcacagt ccttgaaaag      780

gtccctgtat caaaaggcca actgaagcaa tacttctacg agaccaagtg caatcccatg      840

ggttacacaa aagaaggctg caggggcata gacaaaaggc attggaactc ccagtgccga      900

actacccagt cgtacgtgcg ggcccttacc atggatagca aaaagagaat tggctggcga      960

ttcataagga tagacacttc ttgtgtatgt acattgacca ttaaaagggg aagatagtgg     1020

atttatgttg tatagattag attatattga gacaaaaatt atctatttgt atatatacat     1080

aacagggtaa attattcagt taagaaaaaa ataattttat gaactgcatg tataaatgaa     1140

gtttatacag tacagtggtt ctacaatcta tttattggac atgtccatga ccagaaggga     1200

aacagtcatt tgcgcacaac ttaaaaagtc tgcattacat tccttgataa tgttgtggtt     1260

tgttgccgtt gccaagaact gaaaacataa aaagttaaaa aaaataataa attgcatgct     1320

gctttaattg tgaattgata ataaactgtc ctctttcaga aaacagaaaa aaaacacaca     1380

cacacacaac aaaaatttga accaaaacat tccgtttaca ttttagacag taagtatctt     1440

cgttcttgtt agtactatat ctgttttact gcttttaact tctgatagcg ttggaattaa     1500

aacaatgtca aggtgctgtt gtcattgctt tactggctta ggggatgggg gatggggggt     1560

atatttttgt ttgttttgtg tttttttttc gtttgtttgt tttgtttttt agttcccaca     1620

gggagtagag atggggaaag aattcctaca atatatattc tggctgataa aagatacatt     1680

tgtatgttgt gaagatgttt gcaatatcga tcagatgact agaaagtgaa taaaaattaa     1740

ggcaactgaa caaaaaaatg ctcacactcc acatcccgtg atgcacctcc caggccccgc     1800

tcattctttg ggcgttggtc agagtaagct gcttttgacg gaaggaccta tgtttgctca     1860

gaacacattc tttccccccc tccccctctg gtctcctctt tgttttgttt taaggaagaa     1920

aaatcagttg cgcgttctga aatattttac cactgctgtg aacaagtgaa cacattgtgt     1980

cacatcatga cactcgtata agcatggaga acagtgattt ttttttagaa cagaaaacaa     2040

caaaaaataa ccccaaaatg aagattattt tttatgagga gtgaacattt gggtaaatca     2100

tggctaagct taaaaaaaac tcatggtgag gcttaacaat gtcttgtaag caaaaggtag     2160

agccctgtat caacccagaa acacctagat cagaacagga atccacattg ccagtgacat     2220

gagactgaac agccaaatgg aggctatgtg gagttggcat tgcatttacc ggcagtgcgg     2280

gaggaatttc tgagtggcca tcccaaggtc taggtggagg tggggcatgg tatttgagac     2340

attccaaaac gaaggcctct gaaggaccct tcagaggtgg ctctggaatg acatgtgtca     2400

agctgcttgg acctcgtgct ttaagtgcct acattatcta actgtgctca agaggttctc     2460

gactggagga ccacactcaa gccgacttat gcccaccatc ccacctctgg ataattttgc     2520

ataaaattgg attagcctgg agcaggttgg gagccaaatg tggcatttgt gatcatgaga     2580

ttgatgcaat gagatagaag atgtttgcta cctgaacact tattgctttg aaactagact     2640

tgaggaaacc agggtttatc ttttgagaac ttttggtaag ggaaaaggga acaggaaaag     2700

aaaccccaaa ctcaggccga atgatcaagg ggacccatag gaaatcttgt ccagagacaa     2760

gacttcggga aggtgtctgg acattcagaa caccaagact tgaaggtgcc ttgctcaatg     2820

gaagaggcca ggacagagct gacaaaattt tgctccccag tgaaggccac agcaaccttc     2880

tgcccatcct gtctgttcat ggagagggtc cctgcctcac ctctgccatt ttgggttagg     2940

agaagtcaag ttgggagcct gaaatagtgg ttcttggaaa aatggatccc cagtgaaaac     3000

tagagctcta agcccattca gcccatttca cacctgaaaa tgttagtgat caccacttgg     3060

accagcatcc ttaagtatca gaaagcccca agcaattgct gcatcttagt agggtgaggg     3120

ataagcaaaa gaggatgttc accataaccc aggaatgaag ataccatcag caaagaattt     3180

caatttgttc agtctttcat ttagagctag tctttcacag taccatctga atacctcttt     3240

gaaagaagga agactttacg tagtgtagat ttgttttgtg ttgtttgaaa atattatctt     3300

tgtaattatt tttaatatgt aaggaatgct tggaatatct gctatatgtc aactttatgc     3360

agcttccttt tgagggacaa atttaaaaca aacaaccccc catcacaaac ttaaaggatt     3420

gcaagggcca gatctgttaa gtggtttcat aggagacaca tccagcaatt gtgtggtcag     3480

tggctctttt acccaataag atacatcaca gtcacatgct tgatggttta tgttgaccta     3540

agatttattt tgttaaaatc tctctctgtt gtgttcgttc ttgttctgtt ttgttttgtt     3600

ttttaaagtc ttgctgtggt ctctttgtgg cagaagtgtt tcatgcatgg cagcaggcct     3660

gttgcttttt tatggcgatt cccattgaaa atgtaagtaa atgtctgtgg ccttgttctc     3720

tctatggtaa agatattatt caccatgtaa aacaaaaaac aatatttatt gtattttagt     3780

atatttatat aattatgtta ttgaaaaaaa ttggcattaa aacttaaccg catcagaacc     3840

tattgtaaat acaagttcta tttaagtgta ctaattaaca tataatatat gttttaaata     3900

tagaattttt aatgttttta aatatatttt caaagtacat aaaaaaaaaa aaaaaaaa       3958


<210>  32
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  33
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr 
1               5                   10                  15      


Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Lys 
            20                  25                  30          


Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His Val 
        35                  40                  45              


Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu Glu 
    50                  55                  60                  


Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser Ser 
65                  70                  75                  80  


Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys 
                85                  90                  95      


Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His Ser 
            100                 105                 110         


Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser Glu 
        115                 120                 125             


Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly Gly 
    130                 135                 140                 


Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu Lys 
145                 150                 155                 160 


Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu 
                165                 170                 175     


Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg Thr 
            180                 185                 190         


Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg Ile 
        195                 200                 205             


Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu Thr 
    210                 215                 220                 


Ile Lys Arg Gly Arg 
225                 


<210>  34
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  34

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  35
<211>  4302
<212>  DNA
<213>  Mus musculus

<400>  35
taaagcagta gccggctggt gcagaaaagc aacaagttcc ccagcggtct tcccgcccta       60

gcttgacaag gcgaagggtt tcttacctgg cgacagggaa atctcctgag ccgagctcat      120

ctttgccaga gccccaggtg tgacctgagc agtgggcaaa ggatcggcgt gcaaattgga      180

ttatttttat gggggtactc tgaaactccc tcactttctc tgggaacttt ttgtgctagg      240

gctcagtgac aggcgttgag aaagctgctt caggaaacgc ccgctatata gcagggcaat      300

tggacagtca ttggtaacct cgctcattca ttagaatcac gtaagaactc aaagggaaac      360

gtgtctctca gaatgagggc gtttgcgtaa atctataggt ttttcaacat cgatgccagt      420

tgctttgtct tctgtagtcg ccaaggtgga tgagagttga agctttgcgg atattgcgaa      480

gggttattag attcataagt cacaccaagt ggtgggcgat ccactgagca aagccgaact      540

tctcacatga tgacttcaaa caagacacat taccttcctg catctgttgg ggagacaaga      600

ttttaagaca ctgagtctcc aggacagcaa agccacaatg ttccaccagg tgagaagagt      660

gatgaccatc cttttcctta ctatggttat ttcatacttc ggttgcatga aggcggcgcc      720

catgaaagaa gtaaacgtcc acggacaagg caacttggcc tacccaggtg tgcggaccca      780

tgggactctg gagagcgtga atgggcccag ggcaggttcg agaggtctga cgacgacatc      840

actggctgac acttttgagc acgtcatcga agagctgctg gatgaggacc agaaggttcg      900

gcccaacgaa gaaaaccata aggacgcgga cttgtacact tcccgggtga tgctcagcag      960

tcaagtgcct ttggagcctc ctctactctt tctgctggag gaatacaaaa attacctgga     1020

tgccgcaaac atgtctatga gggttcggcg ccactccgac cctgcccgcc gtggggagct     1080

gagcgtgtgt gacagtatta gcgagtgggt cacagcggca gataaaaaga ctgcagtgga     1140

catgtctggc gggacggtca cagtcctaga gaaagtcccg gtatccaaag gccaactgaa     1200

gcagtatttc tacgagacca agtgtaatcc catgggttac accaaggaag gctgcagggg     1260

catagacaaa aggcactgga actcgcaatg ccgaactacc caatcgtatg ttcgggccct     1320

tactatggat agcaaaaaga gaattggctg gcgattcata aggatagaca cttcctgtgt     1380

atgtacactg accattaaaa ggggaagata gtggatttat gttgtataga ttatattgag     1440

acaaaattat ctatttgtat atatacataa cagggtaaat tattcagtta agaaaaaata     1500

attttatgaa ctgcatgtat aaatgaagtt tatacagtac agtggttcta caatctattt     1560

attggacata tccatgacct gaaaggaaac agtcatttgc gcacaacttt aaaagtctgc     1620

attacattcc tcgataatgt tgtggtttgt tgccgttgcc aagaattgaa aacaaaaagt     1680

ttaaaaaaaa taataataaa ttgcatgctg ctttaattgt gaattgataa taaactgtcc     1740

ctctttcaga aaacagatta aaaaaacaaa aaacaaaaaa aaaaaaacaa aaaacaaaaa     1800

caaaaattgg aaccaaaaca ttccgtttac attttagaca ctaagtatct tcgttcttgt     1860

tagtactctg ttttactgct ttcgacttct gatagcgttg gaattaaaac aatgtcaagg     1920

tgctgttgtc attgctttac tggcgtaagg gacggggaat gggaggggta gatttctgtt     1980

tgttttgtgt tttattttgt ttgtttgttt gttttgtttt ttagttccac ccggagtagg     2040

gatggagaaa atttcttcac tatccattct ggttgataaa gcgttacatt tgtatgttgt     2100

aaagatgttt gcaaaatcca atcagatgac tggaaaacaa ataaaaatta aggcaactga     2160

ataaaatgct cacactccac tgcccatgat gtatctccct ggtccccctc agctcactct     2220

tctggcatgg gtcagggaaa attgctttta ttggaaagac cagcatttgt tcaaagcata     2280

ctctttccct ccctcctccc attttggtcc cttctttttg ttttgtttta agaaagaaaa     2340

ttaagttgcg cgctttaaaa tattttacta ctgctacaaa cagatgaaca atgtgtgtca     2400

ttttatgaca ctcatggaaa acagtgattt ttttttaccc taaagaaaaa caaataaaaa     2460

taacccaaaa tattcttttt ttaaaaggca taaatattgg gtaaattgta atatggccta     2520

acagtgtttg cagataaaag ttattgtata cacccagata cttagataag agcagggatc     2580

cacactgcca ttgaaatagg actgaatggc cctgcggagg ctaagtggag ctgacatact     2640

atttcctggc agtgcaggag gaatttctga gtggccatcc taaggtctag gatggaggtg     2700

gggaatggta cttgagacat tcctaaagga aggctcggaa gcacccttca gagcaggctc     2760

tggaatgatg tgtcaagttg cttaggcctt ctgctttaag tgcctacatt acctaacagt     2820

gctcaagagg ttctcgattg gagaaccaca ctcaaatcca tttatagcct ccatcccatt     2880

tctaaataat tgtgtataaa gttggattaa cctggagcaa ctttggatcc aaatatggca     2940

cagcaataat gatattaatg cagcatgatg ggaaatgttt gctgtgaaga gaattgattt     3000

gctttgagct tagacttcag gaagcctagg ttttttattt ttttattttt gagacatttt     3060

ggtaaaagga aaaaaagaaa acaaacaaac aaacaaacaa aaccagaaaa agcatcaaaa     3120

ctcaggcaga atgagcaatg tctgaaaggg ctagaaaaac aagacatagc aaggtgcttt     3180

cactgtgaaa gagacaagaa cacaggagga aatattgctt cagtgaagag cacagacggc     3240

tcctgccaat ttattacaag agtcccgtct gtactttacc ctttggggtt agaagtcaag     3300

ttggaagcct gaatgaatgg acccaatgag aactagtgtt aagcccattt ccctagtcag     3360

gtttttttca agcgtgaatg tgttagtggt tactctcctg ggttcctgag catcagaaaa     3420

aaaaaaaaaa agaggcaaac aatcgcttca tcttaggagt ggaaaggaaa cagaagtgga     3480

cgtccgctgt gactcaggga gtgaagatac catcagcaaa tagtttcttt tttgttcatt     3540

cgttcctttc gagttagcct gtcttttgga ataccactga atatgctgtt tttgaaagac     3600

ttcatgtagc atagattgtt ttgtgccgtt taccaaatta acctttgtca tcgtttttta     3660

acctattcag gaatgcttgg aatatctgct ctatgttaac tttttgcagc ttcattctga     3720

gagacattag tcaaacaaac aaaaggatcc ccatcacaat cttacagtac tgcaagggcc     3780

aggtctgtta atcggcttca caggagacat cagcaattgt gtggtcagtg gctggctctc     3840

ttacccacta agatacatca tagctacatg ttggtggttt atgttgacct gagatttatt     3900

tgttaaaatc tcttcttcgt ttctgttcgt tctggttctg ttctgttctg ttctgttctg     3960

ttttggtttt aaagtcttgc tgtggtctct tgttggcaga aatgttttat gcatggcagc     4020

aggcctgttg cttttttata gtgattccca ttgaaactgt aagtaaatgt ctgtggcctt     4080

gttctctcta tggtaaagat attattcacc atgtaaaaca agaaaaaata tttattgtat     4140

tttagtatat ttatataatt atgttattga aaaaattggc attaaaactt aaccacatca     4200

gaagcctatt gtaaatacag gttctattta agtgtaccaa ttaacatata atatatgttt     4260

taaatataga atttttaatg tttttaaata tattttcaaa gt                        4302


<210>  36
<211>  4161
<212>  DNA
<213>  Mus musculus

<400>  36
gctttggcaa agccatccac acgtgacaaa acgtaaggaa gtggaagaaa ccgtctagag       60

caatatcaag taccacttaa ttagagaata tttttttaac cttttcctcc tcctgcgccg      120

ggtgtgtgat cccggagagc agagtccatt cagcaccttg gacagagcca gcggatttgt      180

ccgaggtggt agtacttcat ccaggtattc ttttcctcgc tgtcaagcca acccggtgtc      240

gcccttaaaa agcgtctttt ccgaggttcg gctcacaccg agatcggggc tggagagaga      300

gtcagatttt ggagcggagc gtttggagag cgagccccag tttggtcccc tcattgagct      360

cgctgaagtt ggcttcctag cggtgtaggc tggaatagac tcttggcaag ctccgggttg      420

gtatactggg ttaactttgg gaaatgcaag tgtttatcac caggatctag ccaccggggt      480

ggtgtaagcc gcaaagaagt tccaccaggt gagaagagtg atgaccatcc ttttccttac      540

tatggttatt tcatacttcg gttgcatgaa ggcggcgccc atgaaagaag taaacgtcca      600

cggacaaggc aacttggcct acccaggtgt gcggacccat gggactctgg agagcgtgaa      660

tgggcccagg gcaggttcga gaggtctgac gacgacatca ctggctgaca cttttgagca      720

cgtcatcgaa gagctgctgg atgaggacca gaaggttcgg cccaacgaag aaaaccataa      780

ggacgcggac ttgtacactt cccgggtgat gctcagcagt caagtgcctt tggagcctcc      840

tctactcttt ctgctggagg aatacaaaaa ttacctggat gccgcaaaca tgtctatgag      900

ggttcggcgc cactccgacc ctgcccgccg tggggagctg agcgtgtgtg acagtattag      960

cgagtgggtc acagcggcag ataaaaagac tgcagtggac atgtctggcg ggacggtcac     1020

agtcctagag aaagtcccgg tatccaaagg ccaactgaag cagtatttct acgagaccaa     1080

gtgtaatccc atgggttaca ccaaggaagg ctgcaggggc atagacaaaa ggcactggaa     1140

ctcgcaatgc cgaactaccc aatcgtatgt tcgggccctt actatggata gcaaaaagag     1200

aattggctgg cgattcataa ggatagacac ttcctgtgta tgtacactga ccattaaaag     1260

gggaagatag tggatttatg ttgtatagat tatattgaga caaaattatc tatttgtata     1320

tatacataac agggtaaatt attcagttaa gaaaaaataa ttttatgaac tgcatgtata     1380

aatgaagttt atacagtaca gtggttctac aatctattta ttggacatat ccatgacctg     1440

aaaggaaaca gtcatttgcg cacaacttta aaagtctgca ttacattcct cgataatgtt     1500

gtggtttgtt gccgttgcca agaattgaaa acaaaaagtt taaaaaaaat aataataaat     1560

tgcatgctgc tttaattgtg aattgataat aaactgtccc tctttcagaa aacagattaa     1620

aaaaacaaaa aacaaaaaaa aaaaaacaaa aaacaaaaac aaaaattgga accaaaacat     1680

tccgtttaca ttttagacac taagtatctt cgttcttgtt agtactctgt tttactgctt     1740

tcgacttctg atagcgttgg aattaaaaca atgtcaaggt gctgttgtca ttgctttact     1800

ggcgtaaggg acggggaatg ggaggggtag atttctgttt gttttgtgtt ttattttgtt     1860

tgtttgtttg ttttgttttt tagttccacc cggagtaggg atggagaaaa tttcttcact     1920

atccattctg gttgataaag cgttacattt gtatgttgta aagatgtttg caaaatccaa     1980

tcagatgact ggaaaacaaa taaaaattaa ggcaactgaa taaaatgctc acactccact     2040

gcccatgatg tatctccctg gtccccctca gctcactctt ctggcatggg tcagggaaaa     2100

ttgcttttat tggaaagacc agcatttgtt caaagcatac tctttccctc cctcctccca     2160

ttttggtccc ttctttttgt tttgttttaa gaaagaaaat taagttgcgc gctttaaaat     2220

attttactac tgctacaaac agatgaacaa tgtgtgtcat tttatgacac tcatggaaaa     2280

cagtgatttt tttttaccct aaagaaaaac aaataaaaat aacccaaaat attctttttt     2340

taaaaggcat aaatattggg taaattgtaa tatggcctaa cagtgtttgc agataaaagt     2400

tattgtatac acccagatac ttagataaga gcagggatcc acactgccat tgaaatagga     2460

ctgaatggcc ctgcggaggc taagtggagc tgacatacta tttcctggca gtgcaggagg     2520

aatttctgag tggccatcct aaggtctagg atggaggtgg ggaatggtac ttgagacatt     2580

cctaaaggaa ggctcggaag cacccttcag agcaggctct ggaatgatgt gtcaagttgc     2640

ttaggccttc tgctttaagt gcctacatta cctaacagtg ctcaagaggt tctcgattgg     2700

agaaccacac tcaaatccat ttatagcctc catcccattt ctaaataatt gtgtataaag     2760

ttggattaac ctggagcaac tttggatcca aatatggcac agcaataatg atattaatgc     2820

agcatgatgg gaaatgtttg ctgtgaagag aattgatttg ctttgagctt agacttcagg     2880

aagcctaggt tttttatttt tttatttttg agacattttg gtaaaaggaa aaaaagaaaa     2940

caaacaaaca aacaaacaaa accagaaaaa gcatcaaaac tcaggcagaa tgagcaatgt     3000

ctgaaagggc tagaaaaaca agacatagca aggtgctttc actgtgaaag agacaagaac     3060

acaggaggaa atattgcttc agtgaagagc acagacggct cctgccaatt tattacaaga     3120

gtcccgtctg tactttaccc tttggggtta gaagtcaagt tggaagcctg aatgaatgga     3180

cccaatgaga actagtgtta agcccatttc cctagtcagg tttttttcaa gcgtgaatgt     3240

gttagtggtt actctcctgg gttcctgagc atcagaaaaa aaaaaaaaaa gaggcaaaca     3300

atcgcttcat cttaggagtg gaaaggaaac agaagtggac gtccgctgtg actcagggag     3360

tgaagatacc atcagcaaat agtttctttt ttgttcattc gttcctttcg agttagcctg     3420

tcttttggaa taccactgaa tatgctgttt ttgaaagact tcatgtagca tagattgttt     3480

tgtgccgttt accaaattaa cctttgtcat cgttttttaa cctattcagg aatgcttgga     3540

atatctgctc tatgttaact ttttgcagct tcattctgag agacattagt caaacaaaca     3600

aaaggatccc catcacaatc ttacagtact gcaagggcca ggtctgttaa tcggcttcac     3660

aggagacatc agcaattgtg tggtcagtgg ctggctctct tacccactaa gatacatcat     3720

agctacatgt tggtggttta tgttgacctg agatttattt gttaaaatct cttcttcgtt     3780

tctgttcgtt ctggttctgt tctgttctgt tctgttctgt tttggtttta aagtcttgct     3840

gtggtctctt gttggcagaa atgttttatg catggcagca ggcctgttgc ttttttatag     3900

tgattcccat tgaaactgta agtaaatgtc tgtggccttg ttctctctat ggtaaagata     3960

ttattcacca tgtaaaacaa gaaaaaatat ttattgtatt ttagtatatt tatataatta     4020

tgttattgaa aaaattggca ttaaaactta accacatcag aagcctattg taaatacagg     4080

ttctatttaa gtgtaccaat taacatataa tatatgtttt aaatatagaa tttttaatgt     4140

ttttaaatat attttcaaag t                                               4161


<210>  37
<211>  4001
<212>  DNA
<213>  Mus musculus

<400>  37
acccactttc ccattcaccg aggagaggac tgctctcgct gccgctcccc ccacccaccc       60

ccggcgagct agcatgaaat ctcccagcct ctgcctagat caaatggagc ttctcgctga      120

aggcgtgcga gtattacctc cgccatgcaa tttccactat caataattta acttctttgc      180

tgcagaacag gagtacatat cggccaccaa agactcgccc cctccccctt ttaactgaag      240

agaaggggaa atatatagta agagtctaga accttgggga ccggtcttcc ccagagcagc      300

tgccttgatg tttactttga caagtagtga ctgaaaaagt tccaccaggt gagaagagtg      360

atgaccatcc ttttccttac tatggttatt tcatacttcg gttgcatgaa ggcggcgccc      420

atgaaagaag taaacgtcca cggacaaggc aacttggcct acccaggtgt gcggacccat      480

gggactctgg agagcgtgaa tgggcccagg gcaggttcga gaggtctgac gacgacatca      540

ctggctgaca cttttgagca cgtcatcgaa gagctgctgg atgaggacca gaaggttcgg      600

cccaacgaag aaaaccataa ggacgcggac ttgtacactt cccgggtgat gctcagcagt      660

caagtgcctt tggagcctcc tctactcttt ctgctggagg aatacaaaaa ttacctggat      720

gccgcaaaca tgtctatgag ggttcggcgc cactccgacc ctgcccgccg tggggagctg      780

agcgtgtgtg acagtattag cgagtgggtc acagcggcag ataaaaagac tgcagtggac      840

atgtctggcg ggacggtcac agtcctagag aaagtcccgg tatccaaagg ccaactgaag      900

cagtatttct acgagaccaa gtgtaatccc atgggttaca ccaaggaagg ctgcaggggc      960

atagacaaaa ggcactggaa ctcgcaatgc cgaactaccc aatcgtatgt tcgggccctt     1020

actatggata gcaaaaagag aattggctgg cgattcataa ggatagacac ttcctgtgta     1080

tgtacactga ccattaaaag gggaagatag tggatttatg ttgtatagat tatattgaga     1140

caaaattatc tatttgtata tatacataac agggtaaatt attcagttaa gaaaaaataa     1200

ttttatgaac tgcatgtata aatgaagttt atacagtaca gtggttctac aatctattta     1260

ttggacatat ccatgacctg aaaggaaaca gtcatttgcg cacaacttta aaagtctgca     1320

ttacattcct cgataatgtt gtggtttgtt gccgttgcca agaattgaaa acaaaaagtt     1380

taaaaaaaat aataataaat tgcatgctgc tttaattgtg aattgataat aaactgtccc     1440

tctttcagaa aacagattaa aaaaacaaaa aacaaaaaaa aaaaaacaaa aaacaaaaac     1500

aaaaattgga accaaaacat tccgtttaca ttttagacac taagtatctt cgttcttgtt     1560

agtactctgt tttactgctt tcgacttctg atagcgttgg aattaaaaca atgtcaaggt     1620

gctgttgtca ttgctttact ggcgtaaggg acggggaatg ggaggggtag atttctgttt     1680

gttttgtgtt ttattttgtt tgtttgtttg ttttgttttt tagttccacc cggagtaggg     1740

atggagaaaa tttcttcact atccattctg gttgataaag cgttacattt gtatgttgta     1800

aagatgtttg caaaatccaa tcagatgact ggaaaacaaa taaaaattaa ggcaactgaa     1860

taaaatgctc acactccact gcccatgatg tatctccctg gtccccctca gctcactctt     1920

ctggcatggg tcagggaaaa ttgcttttat tggaaagacc agcatttgtt caaagcatac     1980

tctttccctc cctcctccca ttttggtccc ttctttttgt tttgttttaa gaaagaaaat     2040

taagttgcgc gctttaaaat attttactac tgctacaaac agatgaacaa tgtgtgtcat     2100

tttatgacac tcatggaaaa cagtgatttt tttttaccct aaagaaaaac aaataaaaat     2160

aacccaaaat attctttttt taaaaggcat aaatattggg taaattgtaa tatggcctaa     2220

cagtgtttgc agataaaagt tattgtatac acccagatac ttagataaga gcagggatcc     2280

acactgccat tgaaatagga ctgaatggcc ctgcggaggc taagtggagc tgacatacta     2340

tttcctggca gtgcaggagg aatttctgag tggccatcct aaggtctagg atggaggtgg     2400

ggaatggtac ttgagacatt cctaaaggaa ggctcggaag cacccttcag agcaggctct     2460

ggaatgatgt gtcaagttgc ttaggccttc tgctttaagt gcctacatta cctaacagtg     2520

ctcaagaggt tctcgattgg agaaccacac tcaaatccat ttatagcctc catcccattt     2580

ctaaataatt gtgtataaag ttggattaac ctggagcaac tttggatcca aatatggcac     2640

agcaataatg atattaatgc agcatgatgg gaaatgtttg ctgtgaagag aattgatttg     2700

ctttgagctt agacttcagg aagcctaggt tttttatttt tttatttttg agacattttg     2760

gtaaaaggaa aaaaagaaaa caaacaaaca aacaaacaaa accagaaaaa gcatcaaaac     2820

tcaggcagaa tgagcaatgt ctgaaagggc tagaaaaaca agacatagca aggtgctttc     2880

actgtgaaag agacaagaac acaggaggaa atattgcttc agtgaagagc acagacggct     2940

cctgccaatt tattacaaga gtcccgtctg tactttaccc tttggggtta gaagtcaagt     3000

tggaagcctg aatgaatgga cccaatgaga actagtgtta agcccatttc cctagtcagg     3060

tttttttcaa gcgtgaatgt gttagtggtt actctcctgg gttcctgagc atcagaaaaa     3120

aaaaaaaaaa gaggcaaaca atcgcttcat cttaggagtg gaaaggaaac agaagtggac     3180

gtccgctgtg actcagggag tgaagatacc atcagcaaat agtttctttt ttgttcattc     3240

gttcctttcg agttagcctg tcttttggaa taccactgaa tatgctgttt ttgaaagact     3300

tcatgtagca tagattgttt tgtgccgttt accaaattaa cctttgtcat cgttttttaa     3360

cctattcagg aatgcttgga atatctgctc tatgttaact ttttgcagct tcattctgag     3420

agacattagt caaacaaaca aaaggatccc catcacaatc ttacagtact gcaagggcca     3480

ggtctgttaa tcggcttcac aggagacatc agcaattgtg tggtcagtgg ctggctctct     3540

tacccactaa gatacatcat agctacatgt tggtggttta tgttgacctg agatttattt     3600

gttaaaatct cttcttcgtt tctgttcgtt ctggttctgt tctgttctgt tctgttctgt     3660

tttggtttta aagtcttgct gtggtctctt gttggcagaa atgttttatg catggcagca     3720

ggcctgttgc ttttttatag tgattcccat tgaaactgta agtaaatgtc tgtggccttg     3780

ttctctctat ggtaaagata ttattcacca tgtaaaacaa gaaaaaatat ttattgtatt     3840

ttagtatatt tatataatta tgttattgaa aaaattggca ttaaaactta accacatcag     3900

aagcctattg taaatacagg ttctatttaa gtgtaccaat taacatataa tatatgtttt     3960

aaatatagaa tttttaatgt ttttaaatat attttcaaag t                         4001


<210>  38
<211>  4009
<212>  DNA
<213>  Mus musculus

<400>  38
ccaatcgaag ctcaaccgaa gagctaaata atgtctgacc ccagtgcctg gctctggctg       60

agctctgggt gcccgtcgct gctgccgtgc cggggcgcac ccgctggctg gctgtcgcac      120

ggttcccagt gcgcccggga ctcccgggct tggagaagga aaccgcctgg ggcggcgcgc      180

cacctccgcc tgggaggctt tgatgagacc cggttccttc aactgccacc actgccttgg      240

ggcagacgag aaagcgcacg gggcccaggg cagggcgcag ggaccagaag cgtgacaaca      300

atgtgactcc actgccgggg atccgagagc tttgtgtgga ccctgagttc caccaggtga      360

gaagagtgat gaccatcctt ttccttacta tggttatttc atacttcggt tgcatgaagg      420

cggcgcccat gaaagaagta aacgtccacg gacaaggcaa cttggcctac ccaggtgtgc      480

ggacccatgg gactctggag agcgtgaatg ggcccagggc aggttcgaga ggtctgacga      540

cgacatcact ggctgacact tttgagcacg tcatcgaaga gctgctggat gaggaccaga      600

aggttcggcc caacgaagaa aaccataagg acgcggactt gtacacttcc cgggtgatgc      660

tcagcagtca agtgcctttg gagcctcctc tactctttct gctggaggaa tacaaaaatt      720

acctggatgc cgcaaacatg tctatgaggg ttcggcgcca ctccgaccct gcccgccgtg      780

gggagctgag cgtgtgtgac agtattagcg agtgggtcac agcggcagat aaaaagactg      840

cagtggacat gtctggcggg acggtcacag tcctagagaa agtcccggta tccaaaggcc      900

aactgaagca gtatttctac gagaccaagt gtaatcccat gggttacacc aaggaaggct      960

gcaggggcat agacaaaagg cactggaact cgcaatgccg aactacccaa tcgtatgttc     1020

gggcccttac tatggatagc aaaaagagaa ttggctggcg attcataagg atagacactt     1080

cctgtgtatg tacactgacc attaaaaggg gaagatagtg gatttatgtt gtatagatta     1140

tattgagaca aaattatcta tttgtatata tacataacag ggtaaattat tcagttaaga     1200

aaaaataatt ttatgaactg catgtataaa tgaagtttat acagtacagt ggttctacaa     1260

tctatttatt ggacatatcc atgacctgaa aggaaacagt catttgcgca caactttaaa     1320

agtctgcatt acattcctcg ataatgttgt ggtttgttgc cgttgccaag aattgaaaac     1380

aaaaagttta aaaaaaataa taataaattg catgctgctt taattgtgaa ttgataataa     1440

actgtccctc tttcagaaaa cagattaaaa aaacaaaaaa caaaaaaaaa aaaacaaaaa     1500

acaaaaacaa aaattggaac caaaacattc cgtttacatt ttagacacta agtatcttcg     1560

ttcttgttag tactctgttt tactgctttc gacttctgat agcgttggaa ttaaaacaat     1620

gtcaaggtgc tgttgtcatt gctttactgg cgtaagggac ggggaatggg aggggtagat     1680

ttctgtttgt tttgtgtttt attttgtttg tttgtttgtt ttgtttttta gttccacccg     1740

gagtagggat ggagaaaatt tcttcactat ccattctggt tgataaagcg ttacatttgt     1800

atgttgtaaa gatgtttgca aaatccaatc agatgactgg aaaacaaata aaaattaagg     1860

caactgaata aaatgctcac actccactgc ccatgatgta tctccctggt ccccctcagc     1920

tcactcttct ggcatgggtc agggaaaatt gcttttattg gaaagaccag catttgttca     1980

aagcatactc tttccctccc tcctcccatt ttggtccctt ctttttgttt tgttttaaga     2040

aagaaaatta agttgcgcgc tttaaaatat tttactactg ctacaaacag atgaacaatg     2100

tgtgtcattt tatgacactc atggaaaaca gtgatttttt tttaccctaa agaaaaacaa     2160

ataaaaataa cccaaaatat tcttttttta aaaggcataa atattgggta aattgtaata     2220

tggcctaaca gtgtttgcag ataaaagtta ttgtatacac ccagatactt agataagagc     2280

agggatccac actgccattg aaataggact gaatggccct gcggaggcta agtggagctg     2340

acatactatt tcctggcagt gcaggaggaa tttctgagtg gccatcctaa ggtctaggat     2400

ggaggtgggg aatggtactt gagacattcc taaaggaagg ctcggaagca cccttcagag     2460

caggctctgg aatgatgtgt caagttgctt aggccttctg ctttaagtgc ctacattacc     2520

taacagtgct caagaggttc tcgattggag aaccacactc aaatccattt atagcctcca     2580

tcccatttct aaataattgt gtataaagtt ggattaacct ggagcaactt tggatccaaa     2640

tatggcacag caataatgat attaatgcag catgatggga aatgtttgct gtgaagagaa     2700

ttgatttgct ttgagcttag acttcaggaa gcctaggttt tttatttttt tatttttgag     2760

acattttggt aaaaggaaaa aaagaaaaca aacaaacaaa caaacaaaac cagaaaaagc     2820

atcaaaactc aggcagaatg agcaatgtct gaaagggcta gaaaaacaag acatagcaag     2880

gtgctttcac tgtgaaagag acaagaacac aggaggaaat attgcttcag tgaagagcac     2940

agacggctcc tgccaattta ttacaagagt cccgtctgta ctttaccctt tggggttaga     3000

agtcaagttg gaagcctgaa tgaatggacc caatgagaac tagtgttaag cccatttccc     3060

tagtcaggtt tttttcaagc gtgaatgtgt tagtggttac tctcctgggt tcctgagcat     3120

cagaaaaaaa aaaaaaaaga ggcaaacaat cgcttcatct taggagtgga aaggaaacag     3180

aagtggacgt ccgctgtgac tcagggagtg aagataccat cagcaaatag tttctttttt     3240

gttcattcgt tcctttcgag ttagcctgtc ttttggaata ccactgaata tgctgttttt     3300

gaaagacttc atgtagcata gattgttttg tgccgtttac caaattaacc tttgtcatcg     3360

ttttttaacc tattcaggaa tgcttggaat atctgctcta tgttaacttt ttgcagcttc     3420

attctgagag acattagtca aacaaacaaa aggatcccca tcacaatctt acagtactgc     3480

aagggccagg tctgttaatc ggcttcacag gagacatcag caattgtgtg gtcagtggct     3540

ggctctctta cccactaaga tacatcatag ctacatgttg gtggtttatg ttgacctgag     3600

atttatttgt taaaatctct tcttcgtttc tgttcgttct ggttctgttc tgttctgttc     3660

tgttctgttt tggttttaaa gtcttgctgt ggtctcttgt tggcagaaat gttttatgca     3720

tggcagcagg cctgttgctt ttttatagtg attcccattg aaactgtaag taaatgtctg     3780

tggccttgtt ctctctatgg taaagatatt attcaccatg taaaacaaga aaaaatattt     3840

attgtatttt agtatattta tataattatg ttattgaaaa aattggcatt aaaacttaac     3900

cacatcagaa gcctattgta aatacaggtt ctatttaagt gtaccaatta acatataata     3960

tatgttttaa atatagaatt tttaatgttt ttaaatatat tttcaaagt                 4009


<210>  39
<211>  249
<212>  PRT
<213>  Mus musculus

<400>  39

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Val Asn Val His Gly Gln Gly Asn Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Arg Ala Gly Ser Arg Gly Leu Thr Thr Thr Ser Leu Ala Asp Thr 
    50                  55                  60                  


Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 
65                  70                  75                  80  


Pro Asn Glu Glu Asn His Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val 
                85                  90                  95      


Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 
            100                 105                 110         


Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 
        115                 120                 125             


Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 
    130                 135                 140                 


Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 
145                 150                 155                 160 


Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys 
                165                 170                 175     


Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly 
            180                 185                 190         


Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 
        195                 200                 205             


Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 
    210                 215                 220                 


Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val 
225                 230                 235                 240 


Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                245                 


<210>  40
<211>  221
<212>  PRT
<213>  Mus musculus

<400>  40

Ala Pro Met Lys Glu Val Asn Val His Gly Gln Gly Asn Leu Ala Tyr 
1               5                   10                  15      


Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Arg 
            20                  25                  30          


Ala Gly Ser Arg Gly Leu Thr Thr Thr Ser Leu Ala Asp Thr Phe Glu 
        35                  40                  45              


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
    50                  55                  60                  


Glu Glu Asn His Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
65                  70                  75                  80  


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
                85                  90                  95      


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
            100                 105                 110         


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
        115                 120                 125             


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
    130                 135                 140                 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
145                 150                 155                 160 


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
                165                 170                 175     


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
            180                 185                 190         


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
        195                 200                 205             


Arg Ile Gly Trp Cys Thr Leu Thr Ile Lys Arg Gly Arg 
    210                 215                 220     


<210>  41
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  41

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  42
<211>  4252
<212>  DNA
<213>  Rattus norvegicus

<400>  42
taaagcggta gccggctggt gcaggaaagc aacaagttcc ccagcggtct tcccgcccta       60

gcctgacaag gcgaaggttt tcttacctgg cgacagggaa atctcctgag ccgagctcat      120

ctttgccaca gccccaggtg tgacctgagc agtgggcaaa ggagcggcgt gcaaattgga      180

ttatttgtat gggggtactc tgaaactccc tcactttttc tgggaacttt ttgtgctagg      240

gcgcagtgac aggcgttgag aaagctgctt caggaaacgc ccgctatata gcagggcagt      300

tggacagtca ttggtaacct cgctcattca ttagaatcac gtaagaactc aaagggaaac      360

gtgtctctca gaatgagggc gtttgcgtaa atctataggt ttttcaacat cgatgccagt      420

tgctttgtct tctgtaatcg ccaaggtgga tgagagttga agcttgcgga tattgcaaag      480

ggttattaga ttcataagtc acaccaagtg gtgggcgatc cactgagcaa agccgaactt      540

ctcacatgat gacttcaaac aagacacatt accttccagc atctgttggg gagacgagat      600

tttaagacac tgagtctcca ggacagcaaa gccacaatgt tccaccaggt gagaagagtg      660

atgaccatcc ttttccttac tatggttatt tcatacttcg gttgcatgaa ggctgcgccc      720

atgaaagaag caaacgtcca cggacaaggc aacttggcct acccagctgt gcggacccat      780

gggactctgg agagcgtgaa tgggcccagg gcaggttcga gaggtctgac gacgacgtcc      840

ctggctgaca cttttgagca cgtgatcgaa gagctgctgg atgaggacca gaaggttcgg      900

cccaacgaag aaaaccataa ggacgcggac ttgtacactt cccgggtgat gctcagcagt      960

caagtgcctt tggagcctcc tctgctcttt ctgctggagg aatacaaaaa ttacctggat     1020

gccgcaaaca tgtctatgag ggttcggcgc cactccgacc ccgcccgccg tggggagctg     1080

agcgtgtgtg acagtattag cgagtgggtc acagcggcag ataaaaagac tgcagtggac     1140

atgtccggtg ggacggtcac agtcctggag aaagtcccgg tatcaaaagg ccaactgaag     1200

caatatttct acgagaccaa gtgtaatccc atgggttaca cgaaggaagg ctgcaggggc     1260

atagacaaaa ggcactggaa ctcgcaatgc cgaactaccc aatcgtatgt tcgggccctt     1320

actatggata gcaaaaagag aattggctgg cggttcataa ggatagacac ttcctgtgta     1380

tgtacactga ccattaaaag gggaagatag tggatttatg ttgtatagat tatattgaga     1440

caaaaattat ctatttgtat atatacataa cagggtaaat tattcagtta agaaaaagat     1500

aattttatga actgcatgta taaatgaagt ttatacagta cagtggttct acaatctatt     1560

tattggacat atccatgacc agaaagaaac agtcatttgc gcacaacttt aaaagtctgc     1620

attacattcc tcgataatgt tgtggtttgt tgccgttgcc aagaattgaa aacaaaaagt     1680

taaaaaaaat aataaattgc atgctgcttt aattgtgaat tgataataaa ctgtccctct     1740

ttcagaaaac agacaaaaaa acaaaaaaca aaaaaaagca aaaacaaaaa tttgaaccaa     1800

aacattccgt ttacatttta gacactaagt atcttcgttc ttgttagtac tctgttctac     1860

tgctttcaac ttctcatagc gttggaatta aaactatgtc aaggtgctgt tgtcattgct     1920

ttactggctt aggggatggg gaacgggagg ggtagatttc tgtttgtttt gtgttttatt     1980

tcgtttgttt gtttgttttg tttttttagt tccacccgga gtagggatgg agaaaatttc     2040

ttcactctcc attctggttg ataaagcgtt acatttgtat gttgtaaaaa atgtttgcaa     2100

aatccaatca gatgactgga aaacgaataa aaattaaggc aactgaataa aatgctcaca     2160

caacactgcc catgatgtat ctccctggtc ccccaggtca ctcttctggc atgggtcagg     2220

gaaagctgct tttattggaa agaccagcat ttgtttaaag cacattcttt ccctccctcc     2280

tcccattttg gtccctttct tttttgtttt gttttaagaa agaaaattaa gttgcgcgct     2340

ttgaaatatt ttatcactgc tgtgaacaga tgaacaatgt gtgtcatttc atgacactcg     2400

tggaaaacag tgattttttt tttatttttt gccctaagga gaaacaagta agaataaccg     2460

aaaatgttct ttttttttaa aggcataaac agtggataag ttataatatg gcctaacaat     2520

gtttgcagat aaaagatatt gcatacagcc agatactaga gcagggatcc acactgccac     2580

tgaaatgcga ctgaatggcc ctgtggaggc taagtggagc tgacatacta tttcctggca     2640

gagcaggagg aatttctgag tggccatcct gaggtctaga tggaggtggg gaatggtact     2700

tgagacattc ctaaaggaag gctcggaagc acccttcaga gcaggctctg gaatgatgtg     2760

tcaagtttct taggccttct gctttaagtg cctacgttac ctaacagtgc tcaagaggtt     2820

ctcaattgga gaaccacact caaatccatt tatggcctcc atcccatttt aaataattat     2880

ggataaagtt ggattaacct ggagcagctt tggatccaaa tatggcatag cagtgatgct     2940

atcagtgcag catgatggga aatgtttgct gtgaagagac ttaactttct ttgcgcttag     3000

acttcaggaa gcctaggttt tatttattta tttttttgag acattttggt gaaaggaaaa     3060

aagaaagaag aaaacaaaca aacaaaacca gaaaaagcac caaaacttag gcagaatgag     3120

caatgtctgt ctgtaagggc tagaatgaca aggcatagga aggtgctttc actgtgaaag     3180

agacaagaac acaggaggaa atactgctta agtgaagagc acagaaagct cctgatagtt     3240

ctgtccattc agcacaaggg tcccttctac actttacctc ttggggttag gagaagtcaa     3300

gctggaagcc tgaatgaatg gccccaatga gaactagtgt taagcccatt tccctagtga     3360

ggttttccgc cagcgcgaat gtgttagtgg ttacctgact gggctcctgg gcatcagaaa     3420

aagaggcaaa caattgcttc atcttaggag tggaaagggt gaaacaaagt ggctgtccac     3480

tgtgactcag ggagtgaaga taccatcagc aaatagtttc tttttgttca actgttcctt     3540

tagaactagt ctgtcttctg gagtcccact gaatcccctg tttttggaag acttcacgta     3600

gcctagattg ttttgtgccg tttgacaaca ttaatctctg tcatcatttt taacctatta     3660

aggaatgctt tgaatatctg ctatatgcta actttttgca gcttcattct gagagacgtt     3720

agtcaaacaa ataaaaggag ccccatcaca atctcacggt attcgaaggg ccaggtcgat     3780

taggtggctt cataggagac cctccgcaac tgtgtggtca gtggctggct ctcataccca     3840

ctaagataca tcatagctcc atgtcggtgg tttatgttga cctgagattg atttgttaaa     3900

atctctcctc tgtttctgtt cgttctgttt ccgtcctgtt ctgttctgtt ctgttctgaa     3960

agtcttgctg tggtctcttt ttggcagaag tgtttcatgc atggcagcag gcctgatgct     4020

ttttatagtg attcccattg aaactgtaag taaatgtctg tggccttgtt ctctctatgg     4080

taaagatatt attcaccatg taaaacaaga aaaatattta ttgtatttta gtatatttat     4140

ataattatgt tattgaaaaa aattggcatt aaaacttaac cacatcagaa gcctattgta     4200

aatacaggtt ctatttaagt gtaccaatta acatataata tatgttttaa at             4252


<210>  43
<211>  249
<212>  PRT
<213>  Rattus norvegicus

<400>  43

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Val His Gly Gln Gly Asn Leu 
            20                  25                  30          


Ala Tyr Pro Ala Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Arg Ala Gly Ser Arg Gly Leu Thr Thr Thr Ser Leu Ala Asp Thr 
    50                  55                  60                  


Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 
65                  70                  75                  80  


Pro Asn Glu Glu Asn His Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val 
                85                  90                  95      


Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 
            100                 105                 110         


Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 
        115                 120                 125             


Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 
    130                 135                 140                 


Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 
145                 150                 155                 160 


Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys 
                165                 170                 175     


Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly 
            180                 185                 190         


Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 
        195                 200                 205             


Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 
    210                 215                 220                 


Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val 
225                 230                 235                 240 


Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                245                 


<210>  44
<211>  231
<212>  PRT
<213>  Rattus norvegicus

<400>  44

Ala Pro Met Lys Glu Ala Asn Val His Gly Gln Gly Asn Leu Ala Tyr 
1               5                   10                  15      


Pro Ala Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Arg 
            20                  25                  30          


Ala Gly Ser Arg Gly Leu Thr Thr Thr Ser Leu Ala Asp Thr Phe Glu 
        35                  40                  45              


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
    50                  55                  60                  


Glu Glu Asn His Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
65                  70                  75                  80  


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
                85                  90                  95      


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
            100                 105                 110         


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
        115                 120                 125             


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
    130                 135                 140                 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
145                 150                 155                 160 


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
                165                 170                 175     


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
            180                 185                 190         


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
        195                 200                 205             


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
    210                 215                 220                 


Leu Thr Ile Lys Arg Gly Arg 
225                 230     


<210>  45
<211>  119
<212>  PRT
<213>  Rattus norvegicus

<400>  45

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  46
<211>  1207
<212>  DNA
<213>  Bos taurus

<400>  46
ggacgcttga actgcagctg ccaccgctgc tgtggggccg gcggcgagcg gctccgcgac       60

ggggacctgg gctgggcgca ggggccagga gcgggacgac gatgtgactc cgccgccggg      120

gacccgtgag ctttgtgtgg accccgagtt ccaccaggtg agaagagtga tgaccatcct      180

tttccttact atggttattt catacttcgg ttgcatgaag gctgccccca tgaaagaagc      240

caacctccga gcccaaggca gcttggccta cccaggtgtg cggacccatg ggactctgga      300

gagcatgaat gggcccaagg tgggttcaag aggcctgacg tcctcgtcgt cgttggctga      360

cacttttgaa cacgtgatcg aagagctgtt ggacgaggac cagaaagttc ggcccagcga      420

ggaaaacaat aaagacgcgg acatgtacac gtcccgggtg atgctcagca gtcaagtgcc      480

tttggagccc cctctcctct tcctgctcga ggaatacaaa aattacctgg atgccgcaaa      540

catgtccatg agggtccggc gccactcgga ccccgcccgc cgcggggagc tgagcgtgtg      600

tgacagcatc agcgagtggg tgaccgcagc ggataaaaag actgcagtgg acatgtcggg      660

cgggacggtc acggtccttg aaaaagtccc cgtctcaaaa ggccagctga agcagtactt      720

ctacgagacc aagtgcaatc ccatgggtta cacgaaggag ggctgcaggg gcatagacaa      780

gaggcattgg aactcccagt gccgaactac ccagtcgtac gtgcgggccc tcaccatgga      840

tagcaaaaag cgtattggct ggcggttcat acggatagac acttcttgtg tatgtacact      900

gaccattaag aggggaagat agtggcttta tgttgtatag attatattga gacaaaaatg      960

atctatttgt atatatacat aacagggtaa attattcagt taagaaaaaa aataatttta     1020

tgaactgcat gtataaatga agtttataca gtacagtggt tctacaatct atttattgga     1080

catttccatg accagaaggg aaacagtcat tttttgcgca caactttaaa aagtctgctt     1140

tacattcctc aatgttgtgg tttgttgccg ttgccaagaa ttgaaaaacg taaaaaaaaa     1200

aaaaaaa                                                               1207


<210>  47
<211>  250
<212>  PRT
<213>  Bos taurus

<400>  47

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Leu Arg Ala Gln Gly Ser Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Met Asn Gly 
        35                  40                  45              


Pro Lys Val Gly Ser Arg Gly Leu Thr Ser Ser Ser Ser Leu Ala Asp 
    50                  55                  60                  


Thr Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val 
65                  70                  75                  80  


Arg Pro Ser Glu Glu Asn Asn Lys Asp Ala Asp Met Tyr Thr Ser Arg 
                85                  90                  95      


Val Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu 
            100                 105                 110         


Leu Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg 
        115                 120                 125             


Val Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys 
    130                 135                 140                 


Asp Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val 
145                 150                 155                 160 


Asp Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser 
                165                 170                 175     


Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met 
            180                 185                 190         


Gly Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn 
        195                 200                 205             


Ser Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp 
    210                 215                 220                 


Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys 
225                 230                 235                 240 


Val Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                245                 250 


<210>  48
<211>  232
<212>  PRT
<213>  Bos taurus

<400>  48

Ala Pro Met Lys Glu Ala Asn Leu Arg Ala Gln Gly Ser Leu Ala Tyr 
1               5                   10                  15      


Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Met Asn Gly Pro Lys 
            20                  25                  30          


Val Gly Ser Arg Gly Leu Thr Ser Ser Ser Ser Leu Ala Asp Thr Phe 
        35                  40                  45              


Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro 
    50                  55                  60                  


Ser Glu Glu Asn Asn Lys Asp Ala Asp Met Tyr Thr Ser Arg Val Met 
65                  70                  75                  80  


Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu 
                85                  90                  95      


Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg 
            100                 105                 110         


Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser 
        115                 120                 125             


Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met 
    130                 135                 140                 


Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly 
145                 150                 155                 160 


Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr 
                165                 170                 175     


Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln 
            180                 185                 190         


Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys 
        195                 200                 205             


Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys 
    210                 215                 220                 


Thr Leu Thr Ile Lys Arg Gly Arg 
225                 230         


<210>  49
<211>  119
<212>  PRT
<213>  Bos taurus

<400>  49

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  50
<211>  1184
<212>  DNA
<213>  Sus scrofa

<400>  50
aaaccgggca ccaaagattc ccccctaccc cttctttttg accaaaggga acgtgaaaaa       60

ataatagagt ctggggattt cggggccgaa gtcttcccca gagcagctgc cttgatgttt      120

actttgacaa gtagtgactg aaaagttcca ccaggtgaga agagtgatga ccatcctttt      180

ccttactatg gttatttcat acttcggttg catgaaggct gcccccatga aagaagccaa      240

cgtccgagga caaggcagct tggcctaccc aggtgtgcgg acccatggga ctctggagag      300

cgtgaatggg cccaaggcag gttcaagagg cctgacatcg tcgtcatcgt cgtcgttggc      360

ggacactttt gaacacgtga tcgaggagct gttggacgag gaccagaaag ttcggcccaa      420

tgaggaaaac aataaggacg cggacatgta tacgtcccga gtcatgctca gcagtcaagt      480

gcctttggag cctcctcttc tctttctgct ggaggaatac aaaaattacc tggatgctgc      540

aaacatgtcc atgagggtcc ggcgccactc ggaccccgcc cgccgcgggg agctgagcgt      600

gtgcgacagc attagcgagt gggtgacggc ggcggataaa aagacggcag tggacatgtc      660

gggtggcacg gtcacggtcc tcgaaaaagt ccccgtctcg aaaggccaac tgaagcagta      720

cttctacgag accaagtgca atcctatggg gtacacaaag gagggctgca ggggcataga      780

caagaggcac tggaactccc agtgccgaac tacccagtcg tatgtgcggg ccctcaccat      840

ggatagcaaa aaacgaattg gctggcggtt cataaggata gacacttcct gtgtatgtac      900

tttgaccatt aagaggggaa gatagtggct ttatgttgta tagattatat tgagacaaaa      960

attatctatt tgtatatata cataacaggg taaattattc agttaagaaa aaaaataatt     1020

ttatgaactg catgtataaa tgaagtttat acagtacagt ggttctacaa tctatttatt     1080

ggacatttcc atgaccagag ggaaacagtc attttttgcg cacaacttta aaaaaaaagt     1140

ctgcattaca ttcctcgata atgttgtggt ttgttgccgt tgct                      1184


<210>  51
<211>  252
<212>  PRT
<213>  Sus scrofa

<400>  51

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Val Arg Gly Gln Gly Ser Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Ser Ser Ser Ser Ser Leu 
    50                  55                  60                  


Ala Asp Thr Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln 
65                  70                  75                  80  


Lys Val Arg Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp Met Tyr Thr 
                85                  90                  95      


Ser Arg Val Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu 
            100                 105                 110         


Phe Leu Leu Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser 
        115                 120                 125             


Met Arg Val Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser 
    130                 135                 140                 


Val Cys Asp Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr 
145                 150                 155                 160 


Ala Val Asp Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro 
                165                 170                 175     


Val Ser Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn 
            180                 185                 190         


Pro Met Gly Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His 
        195                 200                 205             


Trp Asn Ser Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr 
    210                 215                 220                 


Met Asp Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr 
225                 230                 235                 240 


Ser Cys Val Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                245                 250         


<210>  52
<211>  234
<212>  PRT
<213>  Sus scrofa

<400>  52

Ala Pro Met Lys Glu Ala Asn Val Arg Gly Gln Gly Ser Leu Ala Tyr 
1               5                   10                  15      


Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Lys 
            20                  25                  30          


Ala Gly Ser Arg Gly Leu Thr Ser Ser Ser Ser Ser Ser Leu Ala Asp 
        35                  40                  45              


Thr Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val 
    50                  55                  60                  


Arg Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp Met Tyr Thr Ser Arg 
65                  70                  75                  80  


Val Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu 
                85                  90                  95      


Leu Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg 
            100                 105                 110         


Val Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys 
        115                 120                 125             


Asp Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val 
    130                 135                 140                 


Asp Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser 
145                 150                 155                 160 


Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met 
                165                 170                 175     


Gly Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn 
            180                 185                 190         


Ser Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp 
        195                 200                 205             


Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys 
    210                 215                 220                 


Val Cys Thr Leu Thr Ile Lys Arg Gly Arg 
225                 230                 


<210>  53
<211>  119
<212>  PRT
<213>  Sus scrofa

<400>  53

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  54
<211>  6042
<212>  DNA
<213>  Xenopus laevis

<400>  54
caaatggagc catttaatga agagatgcca ttacgtccac catgcagctt ccactatcaa       60

taatttaaat atcactcgct gagagcccac gaagagcctg aattattttt tttttcctcc      120

cgttgtttat tgtttgtagc cttttaattt tttcccaagg aaagctggaa agaaaacttc      180

accccaacaa acaaaaaaac ccaaaaccta tattatccag agtttcagct gagatcccca      240

atacaagtgt gttgatgtgt tctttgacaa gtactagcta aaataagttc catcaggtga      300

gaagagtgat gaccatcctt ttccttacta tggttatttc atacttcagt tgcatgaaag      360

ctgcccccat gaaagaagcc agtgtcagag gacaaaatgg cctggcctat ccgggtcttc      420

ggacccatgg tactcttgag agcataggtg gtcccagtgg ctcaagagga ggtggacttc      480

cttcactgac agatactttt gagcaagtca tagaagaact cctggaagag gaacaaagca      540

taaggcaaag tgaggaaagc aaggactctg acttgtattc atctagagta atgctaagca      600

gtcaagtacc tttggagcca ccattgcttt tcctacttga ggagtacaaa aactacttgg      660

atgcggcaaa catgtccatg agggtccggc gccactctga cccagccagg cgtggagagc      720

tgagtgtgtg tgacagtatt agtgaatggg ttacagcagc aaacaagaaa actgcagtgg      780

acatgtcggg gcagacagtt actgtcctag aaaaagtccc agtatccaaa ggccaactga      840

agcaatattt ctacgagacc aaatgcaacc ctatgggtta catgaaagaa ggctgcagag      900

gcatagacaa aaggtactgg aactctcagt gccgaactac tcagtcttac gtgcgggctt      960

tcaccatgga tagcaaaaaa aaagttggtt ggcgctttat aagaatagac acttcttgtg     1020

tatgtacact gaccattaaa aggggaagat agtgaattta tcttgtatag attatattga     1080

gaagaaaata tctatttgta tatatacata acagggtaaa ttattccgta agaaaaagaa     1140

aattaatttt atggactgca tgtagaaaaa aaaaaagaag tttatacagt aaagtggttc     1200

tacaatctat ttattgaaca tatccatacc attaaaaaaa cagagtcttc tgcgcacaat     1260

gtaacctgtt tcccgctgaa gtatcttgga acccattgcc gtgcaatgtt ttcctggttc     1320

ctccagccgg ttatgggtta aagggaaaat attcccccag tttctcttcc atttcttttc     1380

tttcacatga acagtaaact atgataatgc atattgttgg gtgtagagaa gaccctttct     1440

ctagcatgta tgagcacagc cgccatattg ctgatcttga ctgaggcatc tccatagatt     1500

tcagcagacg gtgttgtttc tgccggtaaa caccttggct cagatggttc taccgaagat     1560

tggcaaacat ttaagtgttg gacttcttct agatggtgat gctctctgaa agtctatgga     1620

ggactcccag ttcccagttg tagggtttaa atgcaaatat gcagtaggct atattatcat     1680

ccttcactgt ctgtttgggg aacaagaaaa tggaagaggg tatattctcc cttaaagaat     1740

taagcctgcg ttatgttcct caataacatt gtggtttgtt gctgttgcca agaattgaaa     1800

agcataaaag gtaaaaacca agaattgcat gctgcttcag ttgtgaattg acaatatgtc     1860

ttctattcag acaaaatttg aaccaaaaca ttccgtttac atttcacaca gtatactttc     1920

ccgtcggtat tatatctgtt tactgctttt aaacttctgg tcgcgttgga attaaacaat     1980

gtcaaggtgc tgttacagct ttcactgttt taatttaatt tttattttta ttgggggttt     2040

tttttttttt gtttttttaa ctcctgaaaa aagttgcaac gagcttgtca tgaatacatg     2100

tgttctggtt aaaaaaaaaa aaaaaatttt gtatgttgta aaggtgtttg caaactcgaa     2160

tcaaactact gatcaaaaaa ataaaataaa aaaaaaaaac agcaaggcaa acaagaaaat     2220

gatgctcgtg gtacactttt gggactcgca ccggcaacca aagtgtaagc ttcatgtgta     2280

acagaggtaa ttgctttata aatctgctct ttcaacaggc ttctgtgtgc tgctttaaat     2340

gtgtatggcc atttttaggg ggggaaatgg aggtaaatgg tgtcctcaac ctaatgaaag     2400

gctgttgcac caatctatat ataaaataaa gtctgacagc tcatatataa aggaaattgt     2460

aagtcagcac cagaataatg ctggtattag tcagtatttc caatgcaaat gctgcctgaa     2520

tattgtttac ctacgtccca ttggccccgt aacagtgtcc tcaaaatgct aattggaaaa     2580

caaatcagat ctccagtgat cacagcattt ccaaggaaaa tggaaattgg caatgaaatt     2640

tgttttggaa tgaagaagcg taggagaaca tgggccggtt gtgtgtccta agtcaataaa     2700

ggagccatta acacgtgaat ggcacgtagg ctggcatctt gattaaatag cacatctgac     2760

cattaggaga tcttattctg ttgatagtga aagagagatg gaagtgtgct gtagctgaac     2820

ataaaagcca catatacctc agaaccactt ggaaggaaaa gctgtgaatg gctttaaagg     2880

gatactgtcg tctcaaattc ctccctttta tgtatataaa ttgatataat caaaagctac     2940

attacagttg tgttattcag aaggtacacc tttatcagtg cttctgttca ttctacctct     3000

gccaagcttt tgtatatctt tttagtctca ttaataatca gccacataca tatccaataa     3060

gcagtgcagt aaagattggg ccatcaaaat caagagtaat tcattctact ttgccttgtg     3120

ggtcaggaaa ctgataattt aaaaaaaaaa aattacatta catgatacaa taactactac     3180

agtgtccctt taaaggagaa ctaaacccgt gcaatgttaa gtccccactg gcccccctcc     3240

gttgaccccc cttcctgctt cccccttacc ccagaattct tttccctctt gaaaaagtga     3300

ccgcacatgc agagtgagcg cagcggagct cacgggcgcc attttattct cttcggtaat     3360

cttcttgtct tcttcctcca cttcggcaat ttccgtctct ttcagcgcat gcgcagttgt     3420

cgcataccgg aagattgctc caacagctca tgcgccatta agccgctcac ttcacgaata     3480

ttaacaaaga gaagaagatg gcgtctgtga gcttctctgc tctcacgctg ggagggggcc     3540

aacggagtgg gccagtggga acttaacatc agctttagtt ctcctttaag gccacacttt     3600

tatacttcat caagcagcct agtaccccca tgaggttctg cagtagctca ggcctaatgt     3660

ggtagaacaa atattttgtg ctgttcccaa atttgctaaa tcttaacttg cctttctatt     3720

gttcataatt ggcttcaggc tccattttag ggttgggcat gaatttgtga aattagaaga     3780

atcagacggg aaaccaaaaa aaacagctaa tctgaaaacc aagctattta aaggtcagct     3840

aggaaaatga tgcttaggac cttgccatca cttcttgaca gtggaaaatt caattacatc     3900

tgataagtag gataatgttt ggagtggcat ttaccccagc attgttcatt aaagattccc     3960

tctaacaatc tgtcagcgga aagtgaaata agacatggta gtcccttact gcaccactgt     4020

aagccttaga aggaggctca gatttgggaa tactggtcct gaaccttact ttacttgcct     4080

tagcaggagg gttggataaa gtggccatgt tttcaggtca tggtggtcat gttttaggtg     4140

ccaggtgcaa ccctgttgct gaaatgcaac tccttagtct tagtttagca acagctagag     4200

agttagtatg tgagctatca aaagttctgg gcatcttaag tcatcatcta tagtttacac     4260

caattttact aggtaaagaa gacctcatca agactaaatg agctatactg gacatagagc     4320

acaactggcc ccaaaatcca cagtataatg ccattcactg tatcaaaaat taaatgatgt     4380

aatgaagcta aggaacaaga atgtctcgcc cagcggatct agccaaagat gtgctaggag     4440

aaagctgaag gcaatgtcaa ttgaagatca atatgagtta atcacatgtc tagggaatgg     4500

acaattaaag tggaaacaac agcagctaca caatgagcgt ggatttcata ttactatcta     4560

cagtagagct gaaattctct agagtgtacc ataatatctt tgtttacttt atttaatcta     4620

gtgatgtgta tctttatcta ctgcccaaag ccagatataa tattaataac gtccaaagcc     4680

taaattgttg gttccttctc aacaagttgg ggaagccttc taatcattga acaaagcttg     4740

agttttgaga aggcatgacc ttgattagta ttggtttcac tgtttgcttt gtcatatatg     4800

ggtgtgcgca tgtgtatata tagacatata ggctcatcgg tctgtgaccg cgctcttatt     4860

tctccatgta cacgtggaca caaatatatg tataaacccc tacttgattt cttttatatg     4920

gagtatgaga aggctccctc actcgcagga gaaatataaa tatatttttt tttcaactaa     4980

cactattcag tctatgcatt tacgctagga tgatcaacga gtcatctgga tgccctaact     5040

tttgccttga acctttgcct agaaaaaaaa ggcgtgtatg tgtgtttgtc tgtaaaaaga     5100

agttaaaaaa aaattccatc agtcaatgag aagatgttct tgaagcttaa agctccctta     5160

aatatgggtt gcagctcata gacttttttg tttcctacac ccagatctac aaatctatat     5220

gataaagcag ggggagaact catgagagcc ggagaagtca agaagtggcc ttccttagct     5280

gtcagatata tagcggccat gaccctctat catgtccccc aatactgtgg tctaaaaaaa     5340

gaaatgtcct cctatatgtt tgtgtttgtc tgtatataca agtacgcaat cagtgtatac     5400

atgactttaa aaaatatgca aaactattaa gtggaaacaa tatgaggcag ttagaataga     5460

ttcagcagtg cgaggatata ttgtctgttc tgttggacgc aaagcgacgt aacgtacaaa     5520

aaaagctact acatgccact gaatatacct gtcggatact aggcttggca gttttagctg     5580

aactgagctg caacacagac ttttttttat tttatttatt ttcgttattt ttttctttgt     5640

ctttttcgat aattttgttt tgccgtggtc tgtttgtggc aaacgtatat tctgcatgtc     5700

acctgcctac cgccttgtta aaaaaagtga gacactttga aaatgtaagt tttatgtatg     5760

tgaccttgtt ctttctggaa aaaaaaaggt atatattttc acgatgtgta agaaatattt     5820

attgtatgtt aagtatattt atataattat gttattgaaa catggagatt ggcatttaaa     5880

aatggaagca tttgaaacat attgtaaata ggattacctc tatttaagtg tactacataa     5940

catataatat atgttgaaaa atagaaattt ttaatgtttt taaatatatt ttcaaaatat     6000

ataaactaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                        6042


<210>  55
<211>  247
<212>  PRT
<213>  Xenopus laevis

<400>  55

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Ser Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Ser Val Arg Gly Gln Asn Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Leu Arg Thr His Gly Thr Leu Glu Ser Ile Gly Gly 
        35                  40                  45              


Pro Ser Gly Ser Arg Gly Gly Gly Leu Pro Ser Leu Thr Asp Thr Phe 
    50                  55                  60                  


Glu Gln Val Ile Glu Glu Leu Leu Glu Glu Glu Gln Ser Ile Arg Gln 
65                  70                  75                  80  


Ser Glu Glu Ser Lys Asp Ser Asp Leu Tyr Ser Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asn Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gln Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Met 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg Tyr Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Phe Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Lys Val Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  56
<211>  114
<212>  PRT
<213>  Xenopus laevis

<400>  56

Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser 
1               5                   10                  15      


Ile Ser Glu Trp Val Thr Ala Ala Asn Lys Lys Thr Ala Val Asp Met 
            20                  25                  30          


Ser Gly Ala Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly 
        35                  40                  45              


Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr 
    50                  55                  60                  


Met Lys Glu Gly Cys Arg Gly Ile Glu Lys Arg Tyr Trp Asn Ser Gln 
65                  70                  75                  80  


Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Phe Thr Met Asp Ser Lys 
                85                  90                  95      


Lys Lys Val Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys 
            100                 105                 110         


Thr Leu 
        


<210>  57
<211>  114
<212>  PRT
<213>  Xenopus laevis

<400>  57

Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser 
1               5                   10                  15      


Ile Ser Glu Trp Val Thr Ala Ala Asn Lys Lys Thr Ala Val Asp Met 
            20                  25                  30          


Ser Gly Ala Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly 
        35                  40                  45              


Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr 
    50                  55                  60                  


Met Lys Glu Gly Cys Arg Gly Ile Glu Lys Arg Tyr Trp Asn Ser Gln 
65                  70                  75                  80  


Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Phe Thr Met Asp Ser Lys 
                85                  90                  95      


Lys Lys Val Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys 
            100                 105                 110         


Thr Leu 
        


<210>  58
<211>  119
<212>  PRT
<213>  Gallus gallus

<400>  58

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Thr 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Glu Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Ala Thr Val Thr Val Leu Glu Lys Val Pro Val Pro Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Lys Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Asn Lys Lys 
                85                  90                  95      


Arg Val Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  59
<211>  119
<212>  PRT
<213>  Canis familiaris

<400>  59

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  60
<211>  113
<212>  PRT
<213>  Macaca mulatta

<400>  60

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu 
    


<210>  61
<211>  119
<212>  PRT
<213>  Felis catus

<400>  61

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Gly Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  62
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  62

Cys Val Pro Val Ser Lys Gly Gln Leu Cys 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  63

Cys Val Cys Val Ser Lys Gly Gln Leu Cys 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  64

Cys Val Pro Cys Ser Lys Gly Gln Leu Cys 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  65

Cys Val Pro Val Cys Lys Gly Gln Leu Cys 
1               5                   10  


<210>  66
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  66

Cys Val Pro Val Ser Lys Gly Gln Leu Cys Glu 
1               5                   10      


<210>  67
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  67

Cys Val Pro Val Cys Lys Gly Gln Leu Cys Glu 
1               5                   10      


