                         SEQUENCE LISTING

<110>  Lowery, Robert
       Zielinski, Tom
 
<120>  GENETICALLY ENGINEERED G-ALPHA PROTEINS AND USES THEREOF

<130>  112520.00029

<150>  US 61/093,184
<151>  2008-08-29

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser 
1               5                   10                  15      


Lys Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg 
            20                  25                  30          


Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu 
    50                  55                  60                  


Glu Cys Lys Gln Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Ile Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly 
                85                  90                  95      


Asp Ser Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly 
            100                 105                 110         


Ala Ala Glu Glu Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys 
        115                 120                 125             


Arg Leu Trp Lys Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp 
145                 150                 155                 160 


Arg Ile Ala Gln Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                165                 170                 175     


Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
            180                 185                 190         


Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
    210                 215                 220                 


Val Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                245                 250                 255     


Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Leu Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro 
        275                 280                 285             


Glu Tyr Ala Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln 
    290                 295                 300                 


Cys Gln Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly 
            340                 345                 350         


Leu Phe 
        


<210>  2
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser 
1               5                   10                  15      


Lys Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg 
            20                  25                  30          


Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu 
    50                  55                  60                  


Glu Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Ile Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala 
                85                  90                  95      


Asp Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys 
            100                 105                 110         


Thr Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile 
        115                 120                 125             


Arg Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu 
145                 150                 155                 160 


Glu Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu 
225                 230                 235                 240 


Met Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile 
    290                 295                 300                 


Gln Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile 
305                 310                 315                 320 


Tyr Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val 
                325                 330                 335     


Phe Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys 
            340                 345                 350         


Gly Leu Phe 
        355 


<210>  3
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser 
1               5                   10                  15      


Lys Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Lys 
            20                  25                  30          


Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Asp 
    50                  55                  60                  


Glu Cys Lys Gln Tyr Lys Val Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Ile Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly 
                85                  90                  95      


Glu Ala Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly 
            100                 105                 110         


Ser Ala Glu Glu Gly Val Met Thr Pro Glu Leu Ala Gly Val Ile Lys 
        115                 120                 125             


Arg Leu Trp Arg Asp Gly Gly Val Gln Ala Cys Phe Ser Arg Ser Arg 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ser Tyr Tyr Leu Asn Asp Leu Asp 
145                 150                 155                 160 


Arg Ile Ser Gln Ser Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                165                 170                 175     


Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
            180                 185                 190         


Asp Leu Tyr Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
    210                 215                 220                 


Val Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                245                 250                 255     


Lys Trp Phe Thr Glu Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Leu Phe Glu Glu Lys Ile Lys Arg Ser Pro Leu Thr Ile Cys Tyr Pro 
        275                 280                 285             


Glu Tyr Thr Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln 
    290                 295                 300                 


Cys Gln Phe Glu Asp Leu Asn Arg Arg Lys Asp Thr Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Glu Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  4
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Gly Val Val Arg Thr Leu Ser Arg Cys Leu Leu Pro Ala Glu 
1               5                   10                  15      


Ala Gly Gly Ala Arg Glu Arg Arg Ala Gly Ser Gly Ala Arg Asp Ala 
            20                  25                  30          


Glu Arg Glu Ala Arg Arg Arg Ser Arg Asp Ile Asp Ala Leu Leu Ala 
        35                  40                  45              


Arg Glu Arg Arg Ala Val Arg Arg Leu Val Lys Ile Leu Leu Leu Gly 
    50                  55                  60                  


Ala Gly Glu Ser Gly Lys Ser Thr Phe Leu Lys Gln Met Arg Ile Ile 
65                  70                  75                  80  


His Gly Arg Glu Phe Asp Gln Lys Ala Leu Leu Glu Phe Arg Asp Thr 
                85                  90                  95      


Ile Phe Asp Asn Ile Leu Lys Gly Ser Arg Val Leu Val Asp Ala Arg 
            100                 105                 110         


Asp Lys Leu Gly Ile Pro Trp Gln Tyr Ser Glu Asn Glu Lys His Gly 
        115                 120                 125             


Met Phe Leu Met Ala Phe Glu Asn Lys Ala Gly Leu Pro Val Glu Pro 
    130                 135                 140                 


Ala Thr Phe Gln Leu Tyr Val Pro Ala Leu Ser Ala Leu Trp Arg Asp 
145                 150                 155                 160 


Ser Gly Ile Arg Glu Ala Phe Ser Arg Arg Ser Glu Phe Gln Leu Gly 
                165                 170                 175     


Glu Ser Val Lys Tyr Phe Leu Asp Asn Leu Asp Arg Ile Gly Gln Leu 
            180                 185                 190         


Asn Tyr Phe Pro Ser Lys Gln Asp Ile Leu Leu Ala Arg Lys Ala Thr 
        195                 200                 205             


Lys Gly Ile Val Glu His Asp Phe Val Ile Lys Lys Ile Pro Phe Lys 
    210                 215                 220                 


Met Val Asp Val Gly Gly Gln Arg Ser Gln Arg Gln Lys Trp Phe Gln 
225                 230                 235                 240 


Cys Phe Asp Gly Ile Thr Ser Ile Leu Phe Met Val Ser Ser Ser Glu 
                245                 250                 255     


Tyr Asp Gln Val Leu Met Glu Asp Arg Arg Thr Asn Arg Leu Val Glu 
            260                 265                 270         


Ser Met Asn Ile Phe Glu Thr Ile Val Asn Asn Lys Leu Phe Phe Asn 
        275                 280                 285             


Val Ser Ile Ile Leu Phe Leu Asn Lys Met Asp Leu Leu Val Glu Lys 
    290                 295                 300                 


Val Lys Thr Val Ser Ile Lys Lys His Phe Pro Asp Phe Arg Gly Asp 
305                 310                 315                 320 


Pro His Arg Leu Glu Asp Val Gln Arg Tyr Leu Val Gln Cys Phe Asp 
                325                 330                 335     


Arg Lys Arg Arg Asn Arg Ser Lys Pro Leu Phe His His Phe Thr Thr 
            340                 345                 350         


Ala Ile Asp Thr Glu Asn Val Arg Phe Val Phe His Ala Val Lys Asp 
        355                 360                 365             


Thr Ile Leu Gln Glu Asn Leu Lys Asp Ile Met Leu Gln 
    370                 375                 380     


<210>  5
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Asp Phe Leu Pro Ser Arg Ser Val Leu Ser Val Cys Phe Pro 
1               5                   10                  15      


Gly Cys Leu Leu Thr Ser Gly Glu Ala Glu Gln Gln Arg Lys Ser Lys 
            20                  25                  30          


Glu Ile Asp Lys Cys Leu Ser Arg Glu Lys Thr Tyr Val Lys Arg Leu 
        35                  40                  45              


Val Lys Ile Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Phe 
    50                  55                  60                  


Leu Lys Gln Met Arg Ile Ile His Gly Gln Asp Phe Asp Gln Arg Ala 
65                  70                  75                  80  


Arg Glu Glu Phe Arg Pro Thr Ile Tyr Ser Asn Val Ile Lys Gly Met 
                85                  90                  95      


Arg Val Leu Val Asp Ala Arg Glu Lys Leu His Ile Pro Trp Gly Asp 
            100                 105                 110         


Asn Ser Asn Gln Gln His Gly Asp Lys Met Met Ser Phe Asp Thr Arg 
        115                 120                 125             


Ala Pro Met Ala Ala Gln Gly Met Val Glu Thr Arg Val Phe Leu Gln 
    130                 135                 140                 


Tyr Leu Pro Ala Ile Arg Ala Leu Trp Ala Asp Ser Gly Ile Gln Asn 
145                 150                 155                 160 


Ala Tyr Asp Arg Arg Arg Glu Phe Gln Leu Gly Glu Ser Val Lys Tyr 
                165                 170                 175     


Phe Leu Asp Asn Leu Asp Lys Leu Gly Glu Pro Asp Tyr Ile Pro Ser 
            180                 185                 190         


Gln Gln Asp Ile Leu Leu Ala Arg Arg Pro Thr Lys Gly Ile His Glu 
        195                 200                 205             


Tyr Asp Phe Glu Ile Lys Asn Val Pro Phe Lys Met Val Asp Val Gly 
    210                 215                 220                 


Gly Gln Arg Ser Glu Arg Lys Arg Trp Phe Glu Cys Phe Asp Ser Val 
225                 230                 235                 240 


Thr Ser Ile Leu Phe Leu Val Ser Ser Ser Glu Phe Asp Gln Val Leu 
                245                 250                 255     


Met Glu Asp Arg Leu Thr Asn Arg Leu Thr Glu Ser Leu Asn Ile Phe 
            260                 265                 270         


Glu Thr Ile Val Asn Asn Arg Val Phe Ser Asn Val Ser Ile Ile Leu 
        275                 280                 285             


Phe Leu Asn Lys Thr Asp Leu Leu Glu Glu Lys Val Gln Ile Val Ser 
    290                 295                 300                 


Ile Lys Asp Tyr Phe Leu Glu Phe Glu Gly Asp Pro His Cys Leu Arg 
305                 310                 315                 320 


Asp Val Gln Lys Phe Leu Val Glu Cys Phe Arg Asn Lys Arg Arg Asp 
                325                 330                 335     


Gln Gln Gln Lys Pro Leu Tyr His His Phe Thr Thr Ala Ile Asn Thr 
            340                 345                 350         


Glu Asn Ile Arg Leu Val Phe Arg Asp Val Lys Asp Thr Ile Leu His 
        355                 360                 365             


Asp Asn Leu Lys Gln Leu Met Leu Gln 
    370                 375         


<210>  6
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys 
1               5                   10                  15      


Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp 
            20                  25                  30          


Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly 
        35                  40                  45              


Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly 
    50                  55                  60                  


Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr 
65                  70                  75                  80  


Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr 
                85                  90                  95      


Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu 
            100                 105                 110         


Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr 
        115                 120                 125             


Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr 
145                 150                 155                 160 


Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln 
                165                 170                 175     


Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr 
            180                 185                 190         


Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly 
        195                 200                 205             


Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr 
    210                 215                 220                 


Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val 
225                 230                 235                 240 


Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg 
                245                 250                 255     


Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe 
            260                 265                 270         


Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu 
        275                 280                 285             


Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala 
    290                 295                 300                 


Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser 
305                 310                 315                 320 


Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn 
                325                 330                 335     


Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn 
            340                 345                 350         


Leu Lys Glu Tyr Asn Leu Val 
        355                 


<210>  7
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
                85                  90                  95      


Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
            100                 105                 110         


Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val 
        115                 120                 125             


Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro 
    130                 135                 140                 


Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg 
145                 150                 155                 160 


Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
                165                 170                 175     


Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro 
            180                 185                 190         


Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
        195                 200                 205             


Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val 
    210                 215                 220                 


Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp 
225                 230                 235                 240 


Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val 
                245                 250                 255     


Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu 
            260                 265                 270         


Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile 
        275                 280                 285             


Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly 
    290                 295                 300                 


Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr 
305                 310                 315                 320 


Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg 
                325                 330                 335     


Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser 
            340                 345                 350         


Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp 
        355                 360                 365             


Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln 
    370                 375                 380                 


Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
385                 390                 


<210>  8
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Cys Arg Gln Ser Ser Glu Glu Lys Glu Ala Ala Arg Arg Ser 
1               5                   10                  15      


Arg Arg Ile Asp Arg His Leu Arg Ser Glu Ser Gln Arg Gln Arg Arg 
            20                  25                  30          


Glu Ile Lys Leu Leu Leu Leu Gly Thr Ser Asn Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Ser Gly Gly Phe Asn Leu Glu 
    50                  55                  60                  


Ala Cys Lys Glu Tyr Lys Pro Leu Ile Ile Tyr Asn Ala Ile Asp Ser 
65                  70                  75                  80  


Leu Thr Arg Ile Ile Arg Ala Leu Ala Ala Leu Arg Ile Asp Phe His 
                85                  90                  95      


Asn Pro Asp Arg Ala Tyr Asp Ala Val Gln Leu Phe Ala Leu Thr Gly 
            100                 105                 110         


Pro Ala Glu Ser Lys Gly Glu Ile Thr Pro Glu Leu Leu Gly Val Met 
        115                 120                 125             


Arg Arg Leu Trp Ala Asp Pro Gly Ala Gln Ala Cys Phe Ser Arg Ser 
    130                 135                 140                 


Ser Glu Tyr His Leu Glu Asp Asn Ala Ala Tyr Tyr Leu Asn Asp Leu 
145                 150                 155                 160 


Glu Arg Ile Ala Ala Ala Asp Tyr Ile Pro Thr Val Glu Asp Ile Leu 
                165                 170                 175     


Arg Ser Arg Asp Met Thr Thr Gly Ile Val Glu Asn Lys Phe Thr Phe 
            180                 185                 190         


Lys Glu Leu Thr Phe Lys Met Val Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Glu Leu Ser Gly Tyr Asp Leu Lys Leu Tyr Glu Asp Asn Gln 
225                 230                 235                 240 


Thr Ser Arg Met Ala Glu Ser Leu Arg Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Asn Trp Phe Ile Asn Thr Ser Leu Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Leu Ala Glu Lys Ile Arg Arg Ile Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Lys Gly Gln Asn Thr Tyr Glu Glu Ala Ala Val Tyr Ile 
    290                 295                 300                 


Gln Arg Gln Phe Glu Asp Leu Asn Arg Asn Lys Glu Thr Lys Glu Ile 
305                 310                 315                 320 


Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Ser Asn Ile Gln Phe Val 
                325                 330                 335     


Phe Asp Ala Val Thr Asp Val Ile Ile Gln Asn Asn Leu Lys Tyr Ile 
            340                 345                 350         


Gly Leu Cys 
        355 


<210>  9
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Met Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Phe Phe Ile Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Gly Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Asn Thr Tyr Glu Asp Ala Ala Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Phe Glu Ser Lys Asn Arg Ser Pro Asn Lys Glu Ile Tyr 
305                 310                 315                 320 


Cys His Met Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Val Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Ala Asn Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  10
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Leu Glu Ser Met Met Ala Cys Cys Leu Ser Asp Glu Val Lys 
1               5                   10                  15      


Glu Ser Lys Arg Ile Asn Ala Glu Ile Glu Lys Gln Leu Arg Arg Asp 
            20                  25                  30          


Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly 
        35                  40                  45              


Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly 
    50                  55                  60                  


Ala Gly Tyr Ser Glu Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr 
65                  70                  75                  80  


Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Glu Thr 
                85                  90                  95      


Leu Lys Ile Leu Tyr Lys Tyr Glu Gln Asn Lys Ala Asn Ala Leu Leu 
            100                 105                 110         


Ile Arg Glu Val Asp Val Glu Lys Val Thr Thr Phe Glu His Gln Tyr 
        115                 120                 125             


Val Ser Ala Ile Lys Thr Leu Trp Glu Asp Pro Gly Ile Gln Glu Cys 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr 
145                 150                 155                 160 


Leu Thr Asp Val Asp Arg Ile Ala Thr Leu Gly Tyr Leu Pro Thr Gln 
                165                 170                 175     


Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr 
            180                 185                 190         


Pro Phe Asp Leu Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly 
        195                 200                 205             


Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr 
    210                 215                 220                 


Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val 
225                 230                 235                 240 


Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg 
                245                 250                 255     


Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe 
            260                 265                 270         


Leu Asn Lys Lys Asp Leu Leu Glu Asp Lys Ile Leu Tyr Ser His Leu 
        275                 280                 285             


Val Asp Tyr Phe Pro Glu Phe Asp Gly Pro Gln Arg Asp Ala Gln Ala 
    290                 295                 300                 


Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser 
305                 310                 315                 320 


Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn 
                325                 330                 335     


Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn 
            340                 345                 350         


Leu Lys Glu Tyr Asn Leu Val 
        355                 


<210>  11
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Arg Ser Leu Thr Trp Arg Cys Cys Pro Trp Cys Leu Thr Glu 
1               5                   10                  15      


Asp Glu Lys Ala Ala Ala Arg Val Asp Gln Glu Ile Asn Arg Ile Leu 
            20                  25                  30          


Leu Glu Gln Lys Lys Gln Asp Arg Gly Glu Leu Lys Leu Leu Leu Leu 
        35                  40                  45              


Gly Pro Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile 
    50                  55                  60                  


Ile His Gly Ala Gly Tyr Ser Glu Glu Glu Arg Lys Gly Phe Arg Pro 
65                  70                  75                  80  


Leu Val Tyr Gln Asn Ile Phe Val Ser Met Arg Ala Met Ile Glu Ala 
                85                  90                  95      


Met Glu Arg Leu Gln Ile Pro Phe Ser Arg Pro Glu Ser Lys His His 
            100                 105                 110         


Ala Ser Leu Val Met Ser Gln Asp Pro Tyr Lys Val Thr Thr Phe Glu 
        115                 120                 125             


Lys Arg Tyr Ala Ala Ala Met Gln Trp Leu Trp Arg Asp Ala Gly Ile 
    130                 135                 140                 


Arg Ala Tyr Tyr Glu Arg Arg Arg Glu Phe His Leu Leu Asp Ser Ala 
145                 150                 155                 160 


Val Tyr Tyr Leu Ser His Leu Glu Arg Ile Thr Glu Glu Gly Tyr Val 
                165                 170                 175     


Pro Thr Ala Gln Asp Val Leu Arg Ser Arg Met Pro Thr Thr Gly Ile 
            180                 185                 190         


Asn Glu Tyr Cys Phe Ser Val Gln Lys Thr Asn Leu Arg Ile Val Asp 
        195                 200                 205             


Val Gly Gly Gln Lys Ser Glu Arg Lys Lys Trp Ile His Cys Phe Glu 
    210                 215                 220                 


Asn Val Ile Ala Leu Ile Tyr Leu Ala Ser Leu Ser Glu Tyr Asp Gln 
225                 230                 235                 240 


Cys Leu Glu Glu Asn Asn Gln Glu Asn Arg Met Lys Glu Ser Leu Ala 
                245                 250                 255     


Leu Phe Gly Thr Ile Leu Glu Leu Pro Trp Phe Lys Ser Thr Ser Val 
            260                 265                 270         


Ile Leu Phe Leu Asn Lys Thr Asp Ile Leu Glu Glu Lys Ile Pro Thr 
        275                 280                 285             


Ser His Leu Ala Thr Tyr Phe Pro Ser Phe Gln Gly Pro Lys Gln Asp 
    290                 295                 300                 


Ala Glu Ala Ala Lys Arg Phe Ile Leu Asp Met Tyr Thr Arg Met Tyr 
305                 310                 315                 320 


Thr Gly Cys Val Asp Gly Pro Glu Gly Ser Lys Lys Gly Ala Arg Ser 
                325                 330                 335     


Arg Arg Leu Phe Ser His Tyr Thr Cys Ala Thr Asp Thr Gln Asn Ile 
            340                 345                 350         


Arg Lys Val Phe Lys Asp Val Arg Asp Ser Val Leu Ala Arg Tyr Leu 
        355                 360                 365             


Asp Glu Ile Asn Leu Leu 
    370                 


<210>  12
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Gly Cys Cys Cys Leu Ser Ala Glu Glu Lys Glu Ser Gln Arg 
1               5                   10                  15      


Ile Ser Ala Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Lys Asp Ala 
            20                  25                  30          


Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser Gly Lys 
        35                  40                  45              


Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly Tyr Ser 
    50                  55                  60                  


Asp Glu Asp Arg Lys Gly Phe Thr Lys Leu Val Tyr Gln Asn Ile Phe 
65                  70                  75                  80  


Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Arg Ile Gln 
                85                  90                  95      


Tyr Val Cys Glu Gln Asn Lys Glu Asn Ala Gln Ile Ile Arg Glu Val 
            100                 105                 110         


Glu Val Asp Lys Val Ser Met Leu Ser Arg Glu Gln Val Glu Ala Ile 
        115                 120                 125             


Lys Gln Leu Trp Gln Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr Leu Thr Asp Ile 
145                 150                 155                 160 


Asp Arg Ile Ala Thr Pro Ser Phe Val Pro Thr Gln Gln Asp Val Leu 
                165                 170                 175     


Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu 
            180                 185                 190         


Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Arg Lys Trp Ile His Cys Phe Glu Ser Val Thr Ser Ile Ile Phe 
    210                 215                 220                 


Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Ala Glu Cys Asp Asn 
225                 230                 235                 240 


Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Lys Thr Ile Ile Thr 
                245                 250                 255     


Tyr Pro Trp Phe Leu Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu Ile Ser Tyr Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Lys Gln Asp Val Arg Ala Ala Arg Asp Phe 
    290                 295                 300                 


Ile Leu Lys Leu Tyr Gln Asp Gln Asn Pro Asp Lys Glu Lys Val Ile 
305                 310                 315                 320 


Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Asp Asn Ile Arg Phe Val 
                325                 330                 335     


Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Arg Glu Phe 
            340                 345                 350         


Asn Leu Val 
        355 


<210>  13
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Met Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Phe Phe Ile Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Gly Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Asn Thr Tyr Glu Asp Ala Ala Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Phe Glu Ser Lys Asn Arg Ser Pro Asn Lys Glu Ile Tyr 
305                 310                 315                 320 


Cys His Met Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Val Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Ala Asn Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  14
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Lys Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Ile Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Ser Ala Phe Thr Glu Ala Val Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Tyr Glu Ser Lys Asn Lys Ser Ala His Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Val Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Ala Lys Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  15
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Met Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Phe Phe Ile Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Gly Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Asn Thr Tyr Glu Asp Ala Ala Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Phe Glu Ser Lys Asn Arg Ser Pro Asn Lys Glu Ile Tyr 
305                 310                 315                 320 


Cys His Met Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Val Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Ala Asn Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  16
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Cys Leu Gly Gly Asn Ser Lys Thr Thr Glu Asp Gln Gly Val 
1               5                   10                  15      


Asp Glu Lys Glu Arg Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu 
            20                  25                  30          


Gln Lys Glu Arg Leu Ala Tyr Lys Ala Thr His Arg Leu Leu Leu Leu 
        35                  40                  45              


Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile 
    50                  55                  60                  


Leu His Val Asn Gly Phe Asn Pro Glu Glu Lys Lys Gln Lys Ile Leu 
65                  70                  75                  80  


Asp Ile Arg Lys Asn Val Lys Asp Ala Ile Val Thr Ile Val Ser Ala 
                85                  90                  95      


Met Ser Thr Ile Ile Pro Pro Val Pro Leu Ala Asn Pro Glu Asn Gln 
            100                 105                 110         


Phe Arg Ser Asp Tyr Ile Lys Ser Ile Ala Pro Ile Thr Asp Phe Glu 
        115                 120                 125             


Tyr Ser Gln Glu Phe Phe Asp His Val Lys Lys Leu Trp Asp Asp Glu 
    130                 135                 140                 


Gly Val Lys Ala Cys Phe Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp 
145                 150                 155                 160 


Cys Ala Gln Tyr Phe Leu Glu Arg Ile Asp Ser Val Ser Leu Val Asp 
                165                 170                 175     


Tyr Thr Pro Thr Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser 
            180                 185                 190         


Gly Ile Phe Glu Thr Arg Phe Gln Val Asp Lys Val Asn Phe His Met 
        195                 200                 205             


Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys 
    210                 215                 220                 


Phe Asn Asp Val Thr Ala Ile Ile Tyr Val Ala Ala Cys Ser Ser Tyr 
225                 230                 235                 240 


Asn Met Val Ile Arg Glu Asp Asn Asn Thr Asn Arg Leu Arg Glu Ser 
                245                 250                 255     


Leu Asp Leu Phe Glu Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile 
            260                 265                 270         


Ser Ile Ile Leu Phe Leu Asn Lys Gln Asp Met Leu Ala Glu Lys Val 
        275                 280                 285             


Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Tyr Ala Asn 
    290                 295                 300                 


Tyr Thr Val Pro Glu Asp Ala Thr Pro Asp Ala Gly Glu Asp Pro Lys 
305                 310                 315                 320 


Val Thr Arg Ala Lys Phe Phe Ile Arg Asp Leu Phe Leu Arg Ile Ser 
                325                 330                 335     


Thr Ala Thr Gly Asp Gly Lys His Tyr Cys Tyr Pro His Phe Thr Cys 
            340                 345                 350         


Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp 
        355                 360                 365             


Ile Ile Gln Arg Met His Leu Lys Gln Tyr Glu Leu Leu 
    370                 375                 380     


<210>  17
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser 
1               5                   10                  15      


Lys Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Lys 
            20                  25                  30          


Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Asp 
    50                  55                  60                  


Glu Cys Lys Gln Tyr Lys Val Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Ile Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly 
                85                  90                  95      


Glu Ala Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly 
            100                 105                 110         


Ser Ala Glu Glu Gly Val Met Thr Pro Glu Leu Ala Gly Val Ile Lys 
        115                 120                 125             


Arg Leu Trp Arg Asp Gly Gly Val Gln Ala Cys Phe Ser Arg Ser Arg 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ser Tyr Tyr Leu Asn Asp Leu Asp 
145                 150                 155                 160 


Arg Ile Ser Gln Ser Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                165                 170                 175     


Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
            180                 185                 190         


Asp Leu Tyr Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
    210                 215                 220                 


Val Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                245                 250                 255     


Lys Trp Phe Thr Glu Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Leu Phe Glu Glu Lys Ile Lys Arg Ser Pro Leu Thr Ile Cys Tyr Pro 
        275                 280                 285             


Glu Tyr Thr Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln 
    290                 295                 300                 


Cys Gln Phe Glu Asp Leu Asn Arg Arg Lys Asp Thr Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Glu Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  18
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Ser Glu Lys Ala Thr Lys Val Gln Asp Ile 
                85                  90                  95      


Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser 
            100                 105                 110         


Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg 
        115                 120                 125             


Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro 
    130                 135                 140                 


Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val 
145                 150                 155                 160 


Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala 
                165                 170                 175     


Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val 
            180                 185                 190         


Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile 
        195                 200                 205             


Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp 
    210                 215                 220                 


Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn 
225                 230                 235                 240 


Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met 
                245                 250                 255     


Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn 
            260                 265                 270         


Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val 
        275                 280                 285             


Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala 
    290                 295                 300                 


Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr 
305                 310                 315                 320 


Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr 
                325                 330                 335     


Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala 
            340                 345                 350         


Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val 
        355                 360                 365             


Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile 
    370                 375                 380                 


Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
385                 390                 395 


<210>  19
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Asp Glu Lys Ala Thr Lys Val Gln Asp Ile 
65                  70                  75                  80  


Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser 
                85                  90                  95      


Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg 
            100                 105                 110         


Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro 
        115                 120                 125             


Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val 
    130                 135                 140                 


Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala 
145                 150                 155                 160 


Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val 
                165                 170                 175     


Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile 
            180                 185                 190         


Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp 
        195                 200                 205             


Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn 
    210                 215                 220                 


Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met 
225                 230                 235                 240 


Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn 
                245                 250                 255     


Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val 
            260                 265                 270         


Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala 
        275                 280                 285             


Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr 
    290                 295                 300                 


Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr 
305                 310                 315                 320 


Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala 
                325                 330                 335     


Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val 
            340                 345                 350         


Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile 
        355                 360                 365             


Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
    370                 375                 


<210>  20
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp 
65                  70                  75                  80  


Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met 
                85                  90                  95      


Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe 
            100                 105                 110         


Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe 
        115                 120                 125             


Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly 
    130                 135                 140                 


Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys 
145                 150                 155                 160 


Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr 
                165                 170                 175     


Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly 
            180                 185                 190         


Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe 
        195                 200                 205             


Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe 
    210                 215                 220                 


Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn 
225                 230                 235                 240 


Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu 
                245                 250                 255     


Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser 
            260                 265                 270         


Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu 
        275                 280                 285             


Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr 
    290                 295                 300                 


Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val 
305                 310                 315                 320 


Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr 
                325                 330                 335     


Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala 
            340                 345                 350         


Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile 
        355                 360                 365             


Ile Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
    370                 375                 380 


<210>  21
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Leu Glu Lys Leu Leu Ala Asn Gln Thr Gly Gln Asn Val Phe Gly 
1               5                   10                  15      


Ser Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Ile Glu Phe Trp Leu 
            20                  25                  30          


Ala Cys Glu Asp Tyr Lys Lys Thr Glu Ser Asp Leu Leu Pro Cys Lys 
        35                  40                  45              


Ala Glu Glu Ile Tyr Lys Ala Phe Val His Ser Asp Ala Ala Lys Gln 
    50                  55                  60                  


Ile Asn Ile Asp Phe Arg Thr Arg Glu Ser Thr Ala Lys Lys Ile Lys 
65                  70                  75                  80  


Ala Pro Thr Pro Thr Cys Phe Asp Glu Ala Gln Lys Val Ile Tyr Thr 
                85                  90                  95      


Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Lys Ser Asp Ile Tyr 
            100                 105                 110         


Leu Asn Leu Leu 
        115     


<210>  22
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Phe Asp Glu Leu Leu Ala Ser Lys Tyr Gly Leu Ala Ala Phe Arg 
1               5                   10                  15      


Ala Phe Leu Lys Ser Glu Phe Cys Glu Glu Asn Ile Glu Phe Trp Leu 
            20                  25                  30          


Ala Cys Glu Asp Phe Lys Lys Thr Lys Ser Pro Gln Lys Leu Ser Ser 
        35                  40                  45              


Lys Ala Arg Lys Ile Tyr Thr Asp Phe Ile Glu Lys Glu Ala Pro Lys 
    50                  55                  60                  


Glu Ile Asn Ile Asp Phe Gln Thr Lys Thr Leu Ile Ala Gln Asn Ile 
65                  70                  75                  80  


Gln Glu Ala Thr Ser Gly Cys Phe Thr Thr Ala Gln Lys Arg Val Tyr 
                85                  90                  95      


Ser Leu Met Glu Asn Asn Ser Tyr Pro Arg Phe Leu Glu Ser Glu Phe 
            100                 105                 110         


Tyr Gln Asp Leu Cys 
        115         


<210>  23
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  23

Leu Glu Lys Leu Leu Val His Lys Tyr Gly Leu Ala Val Phe Gln Ala 
1               5                   10                  15      


Phe Leu Arg Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu Ala 
            20                  25                  30          


Cys Glu Asp Phe Lys Lys Val Lys Ser Gln Ser Lys Met Ala Ser Lys 
        35                  40                  45              


Ala Lys Lys Ile Phe Ala Glu Tyr Ile Ala Ile Gln Ala Cys Lys Glu 
    50                  55                  60                  


Val Asn Leu Asp Ser Tyr Thr Arg Glu His Thr Lys Asp Asn Leu Gln 
65                  70                  75                  80  


Ser Val Thr Arg Gly Cys Phe Asp Leu Ala Gln Lys Arg Ile Phe Gly 
                85                  90                  95      


Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Arg Ser Asp Leu Tyr 
            100                 105                 110         


Leu Asp Leu Ile 
        115     


<210>  24
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Leu Glu Asn Leu Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys 
1               5                   10                  15      


Ala Phe Leu Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile 
            20                  25                  30          


Ser Cys Glu Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro 
        35                  40                  45              


Lys Ala Lys Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys 
    50                  55                  60                  


Glu Val Asn Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met 
65                  70                  75                  80  


Leu Glu Pro Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe 
                85                  90                  95      


Asn Leu Met Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe 
            100                 105                 110         


Tyr Leu Asp Leu Val 
        115         


<210>  25
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  25

Leu Asp Lys Leu Leu Gln Asn Asn Tyr Gly Leu Ala Ser Phe Lys Ser 
1               5                   10                  15      


Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Ile Ala 
            20                  25                  30          


Cys Glu Asp Tyr Lys Lys Ile Lys Ser Pro Ala Lys Met Ala Glu Lys 
        35                  40                  45              


Ala Lys Gln Ile Tyr Glu Glu Phe Ile Gln Thr Glu Ala Pro Lys Glu 
    50                  55                  60                  


Val Asn Ile Asp His Phe Thr Lys Asp Ile Thr Met Lys Asn Leu Val 
65                  70                  75                  80  


Glu Pro Ser Leu Ser Ser Phe Asp Met Ala Gln Lys Arg Ile His Ala 
                85                  90                  95      


Leu Met Glu Lys Asp Ser Leu Pro Arg Phe Val Arg Ser Glu Phe Tyr 
            100                 105                 110         


Gln Glu Leu Ile 
        115     


<210>  26
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Phe Asp Glu Ile Leu Lys Asp Gln Val Gly Arg Asp Gln Phe Leu 
1               5                   10                  15      


Arg Phe Leu Glu Ser Glu Phe Ser Ser Glu Asn Leu Arg Phe Trp Leu 
            20                  25                  30          


Ala Val Gln Asp Leu Lys Lys Gln Pro Leu Gln Asp Val Ala Lys Arg 
        35                  40                  45              


Val Glu Glu Ile Trp Gln Glu Phe Leu Ala Pro Gly Ala Pro Ser Ala 
    50                  55                  60                  


Ile Asn Leu Asp Ser His Ser Tyr Glu Ile Thr Ser Gln Asn Val Lys 
65                  70                  75                  80  


Asp Gly Gly Arg Tyr Thr Phe Glu Asp Ala Gln Glu His Ile Tyr Lys 
                85                  90                  95      


Leu Met Lys Ser Asp Ser Tyr Ala Arg Phe Leu Arg Ser Asn Ala Tyr 
            100                 105                 110         


Gln Asp Leu Leu 
        115     


<210>  27
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Met Asp Glu Ala Leu Lys Asp Pro Val Gly Arg Glu Gln Phe Leu 
1               5                   10                  15      


Lys Phe Leu Glu Ser Glu Phe Ser Ser Glu Asn Leu Arg Phe Trp Leu 
            20                  25                  30          


Ala Val Glu Asp Leu Lys Lys Arg Pro Ile Lys Glu Val Pro Ser Arg 
        35                  40                  45              


Val Gln Glu Ile Trp Gln Glu Phe Leu Ala Pro Gly Ala Pro Ser Ala 
    50                  55                  60                  


Ile Asn Leu Asp Ser Lys Ser Tyr Asp Lys Thr Thr Gln Asn Val Lys 
65                  70                  75                  80  


Glu Pro Gly Arg Tyr Thr Phe Glu Asp Ala Gln Glu His Ile Tyr Lys 
                85                  90                  95      


Leu Met Lys Ser Asp Ser Tyr Pro Arg Phe Ile Arg Ser Ser Ala Tyr 
            100                 105                 110         


Gln Glu Leu Leu 
        115     


<210>  28
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Phe Asp Val Leu Leu Ser His Lys Tyr Gly Val Ala Ala Phe Arg 
1               5                   10                  15      


Ala Phe Leu Lys Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu 
            20                  25                  30          


Ala Cys Glu Glu Phe Lys Lys Thr Arg Ser Thr Ala Lys Leu Val Ser 
        35                  40                  45              


Lys Ala His Arg Ile Phe Glu Glu Phe Val Asp Val Gln Ala Pro Arg 
    50                  55                  60                  


Glu Val Asn Ile Asp Phe Gln Thr Arg Glu Ala Thr Arg Lys Asn Leu 
65                  70                  75                  80  


Gln Glu Pro Ser Leu Thr Cys Phe Asp Gln Ala Gln Gly Lys Val His 
                85                  90                  95      


Ser Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Arg Ser Lys Met 
            100                 105                 110         


Tyr Leu Asp Leu Leu 
        115         


<210>  29
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  29

Asn Phe Ser Glu Leu Ile Arg Asp Pro Lys Gly Arg Gln Ser Phe Gln 
1               5                   10                  15      


Tyr Phe Leu Lys Lys Glu Phe Ser Gly Glu Asn Leu Gly Phe Trp Glu 
            20                  25                  30          


Ala Cys Glu Asp Leu Lys Tyr Gly Asp Gln Ser Lys Val Lys Glu Lys 
        35                  40                  45              


Ala Glu Glu Ile Tyr Lys Leu Phe Leu Ala Pro Gly Ala Arg Arg Trp 
    50                  55                  60                  


Ile Asn Ile Asp Gly Lys Thr Met Asp Ile Thr Val Lys Gly Leu Lys 
65                  70                  75                  80  


His Pro His Arg Tyr Val Leu Asp Ala Ala Gln Thr His Ile Tyr Met 
                85                  90                  95      


Leu Met Lys Lys Asp Ser Tyr Ala Arg Tyr Leu Lys Ser Pro Ile Tyr 
            100                 105                 110         


Lys Asp Met Leu 
        115     


<210>  30
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Leu Glu Asn Leu Leu Glu Asp Pro Glu Gly Val Lys Arg Phe Arg 
1               5                   10                  15      


Glu Phe Leu Lys Lys Glu Phe Ser Glu Glu Asn Val Leu Phe Trp Leu 
            20                  25                  30          


Ala Cys Glu Asp Phe Lys Lys Met Gln Asp Lys Thr Gln Met Gln Glu 
        35                  40                  45              


Lys Ala Lys Glu Ile Tyr Met Thr Phe Leu Ser Ser Lys Ala Ser Ser 
    50                  55                  60                  


Gln Val Asn Val Glu Gly Gln Ser Arg Leu Asn Glu Lys Ile Leu Glu 
65                  70                  75                  80  


Glu Pro His Pro Leu Met Phe Gln Lys Leu Gln Asp Gln Ile Phe Asn 
                85                  90                  95      


Leu Met Lys Tyr Asp Ser Tyr Ser Arg Phe Leu Lys Ser Asp Leu Phe 
            100                 105                 110         


Leu Lys His Lys 
        115     


<210>  31
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Phe Arg Glu Leu Leu Glu Asp Pro Val Gly Arg Ala His Phe Met 
1               5                   10                  15      


Asp Phe Leu Gly Lys Glu Phe Ser Gly Glu Asn Leu Ser Phe Trp Glu 
            20                  25                  30          


Ala Cys Glu Glu Leu Arg Tyr Gly Ala Gln Ala Gln Val Pro Thr Leu 
        35                  40                  45              


Val Asp Ala Val Tyr Glu Gln Phe Leu Ala Pro Gly Ala Ala His Trp 
    50                  55                  60                  


Val Asn Ile Asp Ser Arg Thr Met Glu Gln Thr Leu Glu Gly Leu Arg 
65                  70                  75                  80  


Gln Pro His Arg Tyr Val Leu Asp Asp Ala Gln Leu His Ile Tyr Met 
                85                  90                  95      


Leu Met Lys Lys Asp Ser Tyr Pro Arg Phe Leu Lys Ser Asp Met Tyr 
            100                 105                 110         


Lys Ala Leu Leu 
        115     


<210>  32
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Phe Glu Arg Leu Leu Gln Asp Pro Val Gly Val Arg Tyr Phe Ser 
1               5                   10                  15      


Asp Phe Leu Arg Lys Glu Phe Ser Glu Glu Asn Ile Leu Phe Trp Gln 
            20                  25                  30          


Ala Cys Glu Tyr Phe Asn His Val Pro Ala His Asp Lys Lys Glu Leu 
        35                  40                  45              


Ser Tyr Arg Ala Arg Glu Ile Phe Ser Lys Phe Leu Cys Ser Lys Ala 
    50                  55                  60                  


Thr Thr Pro Val Asn Ile Asp Ser Gln Ala Gln Leu Ala Asp Asp Val 
65                  70                  75                  80  


Leu Arg Ala Pro His Pro Asp Met Phe Lys Glu Gln Gln Leu Gln Ile 
                85                  90                  95      


Phe Asn Leu Met Lys Phe Asp Ser Tyr Thr Arg Phe Leu Lys Ser Pro 
            100                 105                 110         


Leu Tyr Gln Glu Cys Ile 
        115             


<210>  33
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Phe Glu Asn Leu Met Ala Thr Lys Tyr Gly Pro Val Val Tyr Ala 
1               5                   10                  15      


Ala Tyr Leu Lys Met Glu His Ser Asp Glu Asn Ile Gln Phe Trp Met 
            20                  25                  30          


Ala Cys Glu Thr Tyr Lys Lys Ile Ala Ser Arg Trp Ser Arg Ile Ser 
        35                  40                  45              


Arg Ala Lys Lys Leu Tyr Lys Ile Tyr Ile Gln Pro Gln Ser Pro Arg 
    50                  55                  60                  


Glu Ile Asn Ile Asp Ser Ser Thr Arg Glu Thr Ile Ile Arg Asn Ile 
65                  70                  75                  80  


Gln Glu Pro Thr Glu Thr Cys Phe Glu Glu Ala Gln Lys Ile Val Tyr 
                85                  90                  95      


Met His Met Glu Arg Asp Ser Tyr Pro Arg Phe Leu Lys Ser Glu Met 
            100                 105                 110         


Tyr Gln Lys Leu Leu 
        115         


<210>  34
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Phe Glu Arg Leu Leu Gln Asp Pro Leu Gly Leu Ala Tyr Phe Thr 
1               5                   10                  15      


Glu Phe Leu Lys Lys Glu Phe Ser Ala Glu Asn Val Thr Phe Trp Lys 
            20                  25                  30          


Ala Cys Glu Arg Phe Gln Gln Ile Pro Ala Ser Asp Thr Gln Gln Leu 
        35                  40                  45              


Ala Gln Glu Ala Arg Asn Ile Tyr Gln Glu Phe Leu Ser Ser Gln Ala 
    50                  55                  60                  


Leu Ser Pro Val Asn Ile Asp Arg Gln Ala Trp Leu Gly Glu Glu Val 
65                  70                  75                  80  


Leu Ala Glu Pro Arg Pro Asp Met Phe Arg Ala Gln Gln Leu Gln Ile 
                85                  90                  95      


Phe Asn Leu Met Lys Phe Asp Ser Tyr Ala Arg Phe Val Lys Ser Pro 
            100                 105                 110         


Leu Tyr Arg Glu Cys Leu 
        115             


<210>  35
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Phe Asp Leu Leu Leu Ser Ser Lys Asn Gly Val Ala Ala Phe His 
1               5                   10                  15      


Ala Phe Leu Lys Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu 
            20                  25                  30          


Ala Cys Glu Glu Phe Lys Lys Ile Arg Ser Ala Thr Lys Leu Ala Ser 
        35                  40                  45              


Arg Ala His Gln Ile Phe Glu Glu Phe Ile Cys Ser Glu Ala Pro Lys 
    50                  55                  60                  


Glu Val Asn Ile Asp His Glu Thr His Glu Leu Thr Arg Met Asn Leu 
65                  70                  75                  80  


Gln Thr Ala Thr Ala Thr Cys Phe Asp Ala Ala Gln Gly Lys Thr Arg 
                85                  90                  95      


Thr Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Lys Ser Pro Ala 
            100                 105                 110         


Tyr Arg Asp Leu Ala 
        115         


<210>  36
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  36

Asn Phe Asp Lys Met Met Lys Ala Pro Ala Gly Arg Asn Leu Phe Arg 
1               5                   10                  15      


Glu Phe Leu Arg Thr Glu Tyr Ser Glu Glu Asn Leu Leu Phe Trp Leu 
            20                  25                  30          


Ala Cys Glu Asp Leu Lys Lys Glu Gln Asn Lys Lys Val Ile Glu Glu 
        35                  40                  45              


Lys Ala Arg Met Ile Tyr Glu Asp Tyr Ile Ser Ile Leu Ser Pro Lys 
    50                  55                  60                  


Glu Val Ser Leu Asp Ser Arg Val Arg Glu Val Ile Asn Arg Asn Leu 
65                  70                  75                  80  


Leu Asp Pro Asn Pro His Met Tyr Glu Asp Ala Gln Leu Gln Ile Tyr 
                85                  90                  95      


Thr Leu Met His Arg Asp Ser Phe Pro Arg Phe Leu Asn Ser Gln Ile 
            100                 105                 110         


Tyr Lys Ser Phe Val 
        115         


<210>  37
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Phe Asp Lys Leu Leu Ser His Arg Asp Gly Leu Glu Ala Phe Thr 
1               5                   10                  15      


Arg Phe Leu Lys Thr Glu Phe Ser Glu Glu Asn Ile Glu Phe Trp Ile 
            20                  25                  30          


Ala Cys Glu Asp Phe Lys Lys Ser Lys Gly Pro Gln Gln Ile His Leu 
        35                  40                  45              


Lys Ala Lys Ala Ile Tyr Glu Lys Phe Ile Gln Thr Asp Ala Pro Lys 
    50                  55                  60                  


Glu Val Asn Leu Asp Phe His Thr Lys Glu Val Ile Thr Asn Ser Ile 
65                  70                  75                  80  


Thr Gln Pro Thr Leu His Ser Phe Asp Ala Ala Gln Ser Arg Val Tyr 
                85                  90                  95      


Gln Leu Met Glu Gln Asp Ser Tyr Thr Arg Phe Leu Lys Ser Asp Ile 
            100                 105                 110         


Tyr Leu Asp Leu Met 
        115         


<210>  38
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Phe Asp Lys Leu Met His Ser Pro Ala Gly Arg Ser Val Phe Arg 
1               5                   10                  15      


Ala Phe Leu Arg Thr Glu Tyr Ser Glu Glu Asn Met Leu Phe Trp Leu 
            20                  25                  30          


Ala Cys Glu Glu Leu Lys Ala Glu Ala Asn Gln His Val Val Asp Glu 
        35                  40                  45              


Lys Ala Arg Leu Ile Tyr Glu Asp Tyr Val Ser Ile Leu Ser Pro Lys 
    50                  55                  60                  


Glu Val Ser Leu Asp Ser Arg Val Arg Glu Gly Ile Asn Lys Lys Met 
65                  70                  75                  80  


Gln Glu Pro Ser Ala His Thr Phe Asp Asp Ala Gln Leu Gln Ile Tyr 
                85                  90                  95      


Thr Leu Met His Arg Asp Ser Tyr Pro Arg Phe Leu Ser Ser Pro Thr 
            100                 105                 110         


Tyr Arg Ala Leu Leu 
        115         


<210>  39
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  39

Ser Phe Asp Lys Leu Met Val Thr Pro Ala Gly Arg Asn Ala Phe Arg 
1               5                   10                  15      


Glu Phe Leu Arg Thr Glu Phe Ser Glu Glu Asn Met Leu Phe Trp Met 
            20                  25                  30          


Ala Cys Glu Glu Leu Lys Lys Glu Ala Asn Lys Asn Ile Ile Glu Glu 
        35                  40                  45              


Lys Ala Arg Ile Ile Tyr Glu Asp Tyr Ile Ser Ile Leu Ser Pro Lys 
    50                  55                  60                  


Glu Val Ser Leu Asp Ser Arg Val Arg Glu Val Ile Asn Arg Asn Met 
65                  70                  75                  80  


Val Glu Pro Ser Gln His Ile Phe Asp Asp Ala Gln Leu Gln Ile Tyr 
                85                  90                  95      


Thr Leu Met His Arg Asp Ser Tyr Pro Arg Phe Met Asn Ser Ala Val 
            100                 105                 110         


Tyr Lys Asp Leu Leu 
        115         


<210>  40
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  40

Asn Met Asp Thr Leu Leu Ala Asn Gln Ala Gly Leu Asp Ala Phe Arg 
1               5                   10                  15      


Ile Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Val Glu Phe Trp Leu 
            20                  25                  30          


Ala Cys Glu Asp Phe Lys Lys Thr Lys Asn Ala Asp Lys Ile Ala Ser 
        35                  40                  45              


Lys Ala Lys Met Ile Tyr Ser Glu Phe Ile Glu Ala Asp Ala Pro Lys 
    50                  55                  60                  


Glu Ile Asn Ile Asp Phe Gly Thr Arg Asp Leu Ile Ser Lys Asn Ile 
65                  70                  75                  80  


Ala Glu Pro Thr Leu Lys Cys Phe Asp Glu Ala Gln Lys Leu Ile Tyr 
                85                  90                  95      


Cys Leu Met Ala Lys Asp Ser Phe Pro Arg Phe Leu Lys Ser Glu Ile 
            100                 105                 110         


Tyr Lys Lys Leu Val 
        115         


<210>  41
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  41

Cys Glu His Ser Gly Asn Lys Leu Trp Lys Asp Ser Val Tyr Phe Trp 
1               5                   10                  15      


Phe Asp Leu Gln Ala Tyr His Gln Leu Phe Tyr Gln Glu Thr Leu Gln 
            20                  25                  30          


Pro Phe Lys Val Cys Lys Gln Ala Gln Tyr Leu Phe Ala Thr Tyr Val 
        35                  40                  45              


Ala Pro Ser Ala Thr Leu Asp Ile Gly Leu Gln Gln Glu Lys Lys Lys 
    50                  55                  60                  


Glu Ile Tyr Met Lys Ile Gln Pro Pro Phe Glu Asp Leu Phe Asp Thr 
65                  70                  75                  80  


Ala Glu Glu Tyr Ile Leu Leu Leu Leu Leu Glu Pro Trp Thr Lys Met 
                85                  90                  95      


Val Lys Ser Asp 
            100 


<210>  42
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  42

Lys Phe Ser Asp Leu Leu Asn Asn Lys Leu Glu Phe Glu His Phe Arg 
1               5                   10                  15      


Gln Phe Leu Glu Thr His Ser Ser Ser Arg Ile Leu Cys Ala Asp Arg 
            20                  25                  30          


His Trp Ser Ser Ser Gly Glu Ile Thr Tyr Arg Asp Arg Asn Gln Arg 
        35                  40                  45              


Lys Ala Lys Ser Ile Tyr Ile Lys Asn Lys Tyr Leu Asn Lys Lys Tyr 
    50                  55                  60                  


Phe Phe Gly Pro Asn Ser Pro Ala Ser Leu Tyr Gln Gln Asn Gln Val 
65                  70                  75                  80  


Met His Leu Ser Gly Gly Trp Gly Lys Ile Leu His Glu Gln Leu Asp 
                85                  90                  95      


Ala Pro Val Leu Val Glu Ile Gln Lys His Val Gln Asn Arg Leu Glu 
            100                 105                 110         


Asn Val Trp Leu Pro Leu Phe Leu Ala Ser Glu Gln Phe 
        115                 120                 125 


<210>  43
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Phe Glu Ser Val Cys Leu Glu Gln Pro Ile Gly Lys Lys Leu Phe 
1               5                   10                  15      


Gln Gln Phe Leu Gln Ser Ala Glu Lys His Leu Pro Ala Leu Glu Leu 
            20                  25                  30          


Trp Lys Asp Ile Glu Asp Tyr Asp Thr Ala Asp Asn Asp Leu Gln Pro 
        35                  40                  45              


Gln Lys Ala Gln Thr Ile Leu Ala Gln Tyr Leu Asp Pro Gln Ala Lys 
    50                  55                  60                  


Leu Phe Cys Ser Phe Leu Asp Glu Gly Ile Val Ala Lys Phe Lys Glu 
65                  70                  75                  80  


Gly Pro Val Glu Ile Gln Asp Gly Leu Phe Gln Pro Leu Leu Gln Ala 
                85                  90                  95      


Thr Leu Ala His Leu Gly Gln Ala Pro Phe Gln Glu Tyr Leu Gly Ser 
            100                 105                 110         


Leu Tyr Phe Leu Arg Phe Leu 
        115                 


<210>  44
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  44

Thr Phe Glu Lys Ile Phe Ser Gln Lys Leu Gly Tyr Leu Leu Phe Arg 
1               5                   10                  15      


Asp Phe Cys Leu Asn His Leu Glu Glu Ala Arg Pro Leu Val Glu Phe 
            20                  25                  30          


Tyr Glu Glu Ile Lys Lys Tyr Glu Lys Leu Glu Thr Glu Glu Glu Arg 
        35                  40                  45              


Val Ala Arg Ser Arg Glu Ile Phe Asp Ser Tyr Ile Met Lys Glu Leu 
    50                  55                  60                  


Leu Ala Cys Ser His Pro Phe Ser Lys Ser Ala Thr Glu His Val Gln 
65                  70                  75                  80  


Gly His Leu Gly Lys Lys Gln Val Pro Pro Asp Leu Phe Gln Pro Tyr 
                85                  90                  95      


Ile Glu Glu Ile Cys Gln Asn Leu Arg Gly Asp Val Phe Gln Lys Phe 
            100                 105                 110         


Ile Glu Ser Asp Lys Phe Thr Arg Phe Cys 
        115                 120         


<210>  45
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  45

Thr Phe Asp Lys Ile Phe Asn Gln Lys Ile Gly Phe Leu Leu Phe Lys 
1               5                   10                  15      


Asp Phe Cys Leu Asn Glu Ile Asn Glu Ala Val Pro Gln Val Lys Phe 
            20                  25                  30          


Tyr Glu Glu Ile Lys Glu Tyr Glu Lys Leu Asp Asn Glu Glu Asp Arg 
        35                  40                  45              


Leu Cys Arg Ser Arg Gln Ile Tyr Asp Ala Tyr Ile Met Lys Glu Leu 
    50                  55                  60                  


Leu Ser Cys Ser His Pro Phe Ser Lys Gln Ala Val Glu His Val Gln 
65                  70                  75                  80  


Ser His Leu Ser Lys Lys Gln Val Thr Ser Thr Leu Phe Gln Pro Tyr 
                85                  90                  95      


Ile Glu Glu Ile Cys Glu Ser Leu Arg Gly Asp Ile Phe Gln Lys Phe 
            100                 105                 110         


Met Glu Ser Asp Lys Phe Thr Arg Phe Cys 
        115                 120         


<210>  46
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Tyr Ser Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg Arg Leu Phe 
1               5                   10                  15      


Arg Gln Phe Cys Asp Thr Lys Pro Thr Leu Lys Arg His Ile Glu Phe 
            20                  25                  30          


Leu Asp Ala Val Ala Glu Tyr Glu Val Ala Asp Asp Glu Asp Arg Ser 
        35                  40                  45              


Asp Cys Gly Leu Ser Ile Leu Asp Arg Phe Phe Asn Asp Lys Leu Ala 
    50                  55                  60                  


Ala Pro Leu Pro Glu Ile Pro Pro Asp Val Val Thr Glu Cys Arg Leu 
65                  70                  75                  80  


Gly Leu Lys Glu Glu Asn Pro Ser Lys Lys Ala Phe Glu Glu Cys Thr 
                85                  90                  95      


Arg Val Ala His Asn Tyr Leu Arg Gly Glu Pro Phe Glu Glu Tyr Gln 
            100                 105                 110         


Glu Ser Ser Tyr Phe Ser Gln Phe Leu 
        115                 120     


<210>  47
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Tyr Cys Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg Leu Leu Phe 
1               5                   10                  15      


Arg Gln Phe Cys Glu Thr Arg Pro Gly Leu Glu Cys Tyr Ile Gln Phe 
            20                  25                  30          


Leu Asp Ser Val Ala Glu Tyr Glu Val Thr Pro Asp Glu Lys Leu Gly 
        35                  40                  45              


Glu Lys Gly Lys Glu Ile Met Thr Lys Tyr Leu Thr Pro Lys Ser Pro 
    50                  55                  60                  


Val Phe Ile Ala Gln Val Gly Gln Asp Leu Val Ser Gln Thr Glu Glu 
65                  70                  75                  80  


Lys Leu Leu Gln Lys Pro Cys Lys Glu Leu Phe Ser Ala Cys Ala Gln 
                85                  90                  95      


Ser Val His Glu Tyr Leu Arg Gly Glu Pro Phe His Glu Tyr Leu Asp 
            100                 105                 110         


Ser Met Phe Phe Asp Arg Phe Leu 
        115                 120 


<210>  48
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Tyr His Ser Leu Cys Glu Arg Gln Pro Ile Gly Arg Leu Leu Phe 
1               5                   10                  15      


Arg Glu Phe Cys Ala Thr Arg Pro Glu Leu Ser Arg Cys Val Ala Phe 
            20                  25                  30          


Leu Asp Gly Val Ala Glu Tyr Glu Val Thr Pro Asp Asp Lys Arg Lys 
        35                  40                  45              


Ala Cys Gly Arg Gln Leu Thr Gln Asn Phe Leu Ser His Thr Gly Pro 
    50                  55                  60                  


Asp Leu Ile Pro Glu Val Pro Arg Gln Leu Val Thr Asn Cys Thr Gln 
65                  70                  75                  80  


Arg Leu Glu Gln Gly Pro Cys Lys Asp Leu Phe Gln Glu Leu Thr Arg 
                85                  90                  95      


Leu Thr His Glu Tyr Leu Ser Val Ala Pro Phe Ala Asp Tyr Leu Asp 
            100                 105                 110         


Ser Ile Tyr Phe Asn Arg Phe Leu 
        115                 120 


<210>  49
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  49

Asn Phe His Ser Leu Cys Glu Gln Gln Pro Ile Gly Arg Arg Leu Phe 
1               5                   10                  15      


Arg Asp Phe Leu Ala Thr Val Pro Thr Phe Arg Lys Ala Ala Thr Phe 
            20                  25                  30          


Leu Glu Asp Val Gln Asn Trp Glu Leu Ala Glu Glu Gly Pro Thr Lys 
        35                  40                  45              


Asp Ser Ala Leu Gln Gly Leu Val Ala Thr Cys Ala Ser Ala Pro Ala 
    50                  55                  60                  


Pro Gly Asn Pro Gln Pro Phe Leu Ser Gln Ala Val Ala Thr Lys Cys 
65                  70                  75                  80  


Gln Ala Ala Thr Thr Glu Glu Glu Arg Val Ala Ala Val Thr Leu Ala 
                85                  90                  95      


Lys Ala Glu Ala Met Ala Phe Leu Gln Glu Gln Pro Phe Lys Asp Phe 
            100                 105                 110         


Val Thr Ser Ala Phe Tyr Asp Lys Phe Leu 
        115                 120         


<210>  50
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  50

Pro Leu Asp Ser Ile Leu Val Asp Asn Val Ala Leu Gln Phe Phe Met 
1               5                   10                  15      


Asp Tyr Met Gln Gln Thr Gly Gly Gln Ala His Leu Phe Phe Trp Met 
            20                  25                  30          


Thr Val Glu Gly Tyr Arg Val Thr Ala Gln Gln Gln Leu Glu Val Leu 
        35                  40                  45              


Leu Ser Arg Gln Arg Asp Gly Lys His Gln Thr Asn Gln Thr Lys Gly 
    50                  55                  60                  


Leu Leu Arg Ala Ala Ala Val Gly Ile Tyr Glu Gln Tyr Leu Ser Glu 
65                  70                  75                  80  


Lys Ala Ser Pro Arg Val Thr Val Asp Asp Tyr Leu Val Ala Lys Leu 
                85                  90                  95      


Ala Asp Thr Leu Asn His Glu Asp Pro Thr Pro Glu Ile Phe Asp Asp 
            100                 105                 110         


Ile Gln Arg Lys Val Tyr Glu Leu Met Leu Arg Asp Glu Arg Phe Tyr 
        115                 120                 125             


Pro Ser Phe Arg Gln Asn Ala Leu Tyr Val Arg Met Leu 
    130                 135                 140     


<210>  51
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  51

Ser Pro Leu Val Pro Phe Leu Gln Lys Phe Ala Glu Pro Arg Asn Lys 
1               5                   10                  15      


Lys Pro Ser Val Leu Lys Leu Glu Leu Lys Gln Ile Arg Glu Gln Gln 
            20                  25                  30          


Asp Leu Leu Phe Arg Phe Met Asn Phe Leu Lys Gln Glu Gly Ala Val 
        35                  40                  45              


His Val Leu Gln Phe Cys Leu Thr Val Glu Glu Phe Asn Asp Arg Ile 
    50                  55                  60                  


Leu Arg Pro Glu Leu Ser Asn Asp Glu Met Leu Ser Leu His Glu Glu 
65                  70                  75                  80  


Leu Gln Lys Ile Tyr Lys Thr Tyr Cys Leu Asp Glu Ser Ile Asp Lys 
                85                  90                  95      


Ile Arg Phe Asp Pro Phe Ile Val Glu Glu Ile Gln Arg Ile Ala Glu 
            100                 105                 110         


Gly Pro Tyr Ile Asp Val Val Lys Leu Gln Thr Met Arg Cys Leu Phe 
        115                 120                 125             


Glu Ala Tyr Glu His Val Leu Ser Leu Leu Glu Asn Val Phe Thr Pro 
    130                 135                 140                 


Met Phe Cys His Ser Asp Glu Tyr Phe Arg Gln Leu Leu Arg Gly Ala 
145                 150                 155                 160 


Glu Ser Pro 
            


<210>  52
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Phe Glu Asp Ile Leu Ala Asn Thr Phe Tyr Arg Glu His Phe Gly 
1               5                   10                  15      


Met Tyr Met Glu Arg Met Asp Lys Arg Ala Leu Ile Ser Phe Trp Glu 
            20                  25                  30          


Ser Val Glu His Leu Lys Asn Ala Asn Lys Asn Glu Ile Pro Gln Leu 
        35                  40                  45              


Val Gly Glu Ile Tyr Gln Asn Phe Phe Val Glu Ser Lys Glu Ile Ser 
    50                  55                  60                  


Val Glu Lys Ser Leu Tyr Lys Glu Ile Gln Gln Cys Leu Val Gly Asn 
65                  70                  75                  80  


Lys Gly Ile Glu Val Phe Tyr Lys Ile Gln Glu Asp Val Tyr Glu Thr 
                85                  90                  95      


Leu Lys Asp Arg Tyr Tyr Pro Ser Phe Ile Val Ser Asp Leu Tyr Glu 
            100                 105                 110         


Lys Leu Leu 
        115 


<210>  53
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Leu His Ser Leu Leu Asp Asp Gln Asp Gly Ile Ser Leu Phe Arg 
1               5                   10                  15      


Thr Phe Leu Lys Gln Glu Gly Cys Ala Asp Leu Leu Asp Phe Trp Phe 
            20                  25                  30          


Ala Cys Thr Gly Phe Arg Lys Leu Glu Pro Cys Asp Ser Asn Glu Glu 
        35                  40                  45              


Lys Arg Leu Lys Leu Ala Arg Ala Ile Tyr Arg Lys Tyr Ile Leu Asp 
    50                  55                  60                  


Asn Asn Gly Ile Val Ser Arg Gln Thr Lys Pro Ala Thr Lys Ser Phe 
65                  70                  75                  80  


Ile Lys Gly Cys Ile Met Lys Gln Leu Ile Asp Pro Ala Met Phe Asp 
                85                  90                  95      


Gln Ala Gln Thr Glu Ile Gln Ala Thr Met Glu Glu Asn Thr Tyr Pro 
            100                 105                 110         


Ser Phe Leu Lys Ser Asp Ile Tyr Leu Glu Tyr Thr 
        115                 120                 


<210>  54
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
1               5                   10                  15      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            20                  25                  30          


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        35                  40                  45              


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    50                  55                  60                  


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
65                  70                  75                  80  


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                85                  90                  95      


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            100                 105                 110         


Ser Asp Ile Tyr Leu Glu Tyr Val 
        115                 120 


<210>  55
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  55

Thr Leu Glu Gln Val Leu His Asp Thr Ile Val Leu Pro Tyr Phe Ile 
1               5                   10                  15      


Gln Phe Met Glu Leu Arg Arg Met Glu His Leu Val Lys Phe Trp Leu 
            20                  25                  30          


Glu Ala Glu Ser Phe His Ser Thr Thr Trp Ser Arg Ile Arg Ala His 
        35                  40                  45              


Ser Leu Asn Thr Met Lys Gln Ser Ser Leu Ala Glu Pro Val Ser Pro 
    50                  55                  60                  


Ser Lys Lys His Glu Thr Thr Ala Ser Phe Leu Thr Asp Ser Leu Asp 
65                  70                  75                  80  


Lys Arg Leu Glu Asp Ser Gly Ser Ala Gln Leu Phe Met Thr His Ser 
                85                  90                  95      


Glu Gly Ile Asp Leu Asn Asn Arg Thr Asn Ser Thr Gln Asn His Leu 
            100                 105                 110         


Leu Leu Ser Gln Glu Cys Asp Ser Ala His Ser Leu Arg Leu Glu Met 
        115                 120                 125             


Ala Arg Ala Gly Thr His Gln Val Ser Met Glu Thr Gln Glu Ser Ser 
    130                 135                 140                 


Ser Thr Leu Thr Val Ala Ser Arg Asn Ser Pro Ala Ser Pro Leu Lys 
145                 150                 155                 160 


Glu Leu Ser Gly Lys Leu Met Lys Ser Ile Glu Gln Asp 
                165                 170             


<210>  56
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  56

Tyr Leu Ala Asp Ile Leu Phe Cys Glu Ser Ala Leu Phe Tyr Phe Ser 
1               5                   10                  15      


Glu Tyr Met Glu Lys Glu Asp Ala Val Asn Ile Leu Gln Phe Trp Leu 
            20                  25                  30          


Ala Ala Asp Asn Phe Gln Ser Gln Leu Ala Ala Lys Lys Gly Gln Tyr 
        35                  40                  45              


Asp Gly Gln Glu Ala Gln Asn Asp Ala Met Ile Leu Tyr Asp Lys Tyr 
    50                  55                  60                  


Phe Ser Leu Gln Ala Thr His Pro Leu Gly Phe Asp Asp Val Val Arg 
65                  70                  75                  80  


Leu Glu Ile Glu Ser Asn Ile Cys Arg Glu Gly Gly Pro Leu Pro Asn 
                85                  90                  95      


Cys Phe Thr Thr Pro Leu Arg Gln Ala Trp Thr Thr Met Glu Lys Val 
            100                 105                 110         


Phe Leu Pro Gly Phe Leu Ser Ser Asn Leu Tyr Tyr Lys Tyr Leu 
        115                 120                 125         


<210>  57
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  57

Asn Ser Gln Phe Gln Ser Leu Glu Gln Val Lys Arg Arg Pro Ala His 
1               5                   10                  15      


Leu Met Ala Leu Leu Gln His Val Ala Leu Gln Phe Glu Pro Gly Pro 
            20                  25                  30          


Leu Leu Cys Cys Leu His Ala Asp Met Leu Gly Ser Leu Gly Pro Lys 
        35                  40                  45              


Glu Ala Lys Lys Ala Phe Leu Asp Phe Tyr His Ser Phe Leu Glu Lys 
    50                  55                  60                  


Thr Ala Val Leu Arg Val Pro Val Pro Pro Asn Val Ala Phe Glu Leu 
65                  70                  75                  80  


Asp Arg Thr Arg Ala Asp Leu Ile Ser Glu Asp Val Gln Arg Arg Phe 
                85                  90                  95      


Val Gln Glu Val Val Gln Ser Gln Gln Val Ala Val Gly Arg Gln Leu 
            100                 105                 110         


Glu Asp Phe Arg Ser Lys Arg Leu Met Gly Met Thr Pro Trp Glu Gln 
        115                 120                 125             


Glu Leu Ala Gln Leu Glu Ala Trp Val Gly Arg Asp Arg Ala Ser Tyr 
    130                 135                 140                 


Glu Ala Arg Glu Arg His Val Ala Glu Arg Leu Leu Met His Leu Glu 
145                 150                 155                 160 


Glu Met Gln His Thr Ile Ser Thr Asp Glu 
                165                 170 


<210>  58
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  58

Asp Leu Glu Lys Leu Lys Ser Arg Pro Ala His Leu Gly Val Phe Leu 
1               5                   10                  15      


Arg Tyr Ile Phe Ser Gln Ala Asp Pro Ser Pro Leu Leu Phe Tyr Leu 
            20                  25                  30          


Cys Ala Glu Val Tyr Gln Gln Ala Ser Pro Lys Asp Ser Arg Ser Leu 
        35                  40                  45              


Gly Lys Asp Ile Trp Asn Ile Phe Leu Glu Lys Asn Ala Pro Leu Arg 
    50                  55                  60                  


Val Lys Ile Pro Glu Met Leu Gln Ala Glu Ile Asp Ser Arg Leu Arg 
65                  70                  75                  80  


Asn Ser Glu Asp Ala Arg Gly Val Leu Cys Glu Ala Gln Glu Ala Ala 
                85                  90                  95      


Met Pro Glu Ile Gln Glu Gln Ile His Asp Tyr Arg Thr Lys Arg Thr 
            100                 105                 110         


Leu Gly Leu Gly Ser Leu Tyr Gly 
        115                 120 


<210>  59
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  59

Cys Ser Cys Phe Gln Ser Ile Glu Leu Leu Lys Ser Arg Pro Ala His 
1               5                   10                  15      


Leu Ala Val Phe Leu His His Val Val Ser Gln Phe Asp Pro Ala Thr 
            20                  25                  30          


Leu Leu Cys Tyr Leu Tyr Ser Asp Leu Tyr Lys His Thr Asn Ser Lys 
        35                  40                  45              


Glu Thr Arg Arg Ile Phe Leu Glu Phe His Gln Phe Phe Leu Asp Arg 
    50                  55                  60                  


Ser Ala His Leu Lys Val Ser Val Pro Asp Glu Met Ser Ala Asp Leu 
65                  70                  75                  80  


Glu Lys Arg Arg Pro Glu Leu Ile Pro Glu Asp Leu His Arg His Tyr 
                85                  90                  95      


Ile Gln Thr Met Gln Glu Arg Val His Pro Glu Val Gln Arg His Leu 
            100                 105                 110         


Glu Asp Phe Arg Gln Lys Arg Ser Met Gly Leu Thr Leu Ala Glu Ser 
        115                 120                 125             


Glu Leu Thr Lys Leu Asp Ala Glu Arg Asp Lys Asp Arg Leu Thr Leu 
    130                 135                 140                 


Glu Lys Glu Arg Thr Cys Ala Glu Gln Ile Val Ala Lys Ile Glu Glu 
145                 150                 155                 160 


Val Leu Met Thr Ala Gln Ala Val Glu Glu Asp Lys Ser Ser 
                165                 170                 


<210>  60
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  R178M A326S double mutant of SEQ ID 1

<400>  60

Met Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser 
1               5                   10                  15      


Lys Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg 
            20                  25                  30          


Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu 
    50                  55                  60                  


Glu Cys Lys Gln Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Ile Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly 
                85                  90                  95      


Asp Ser Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly 
            100                 105                 110         


Ala Ala Glu Glu Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys 
        115                 120                 125             


Arg Leu Trp Lys Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp 
145                 150                 155                 160 


Arg Ile Ala Gln Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                165                 170                 175     


Thr Met Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
            180                 185                 190         


Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
    210                 215                 220                 


Val Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                245                 250                 255     


Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Leu Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro 
        275                 280                 285             


Glu Tyr Ala Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln 
    290                 295                 300                 


Cys Gln Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Phe Thr Cys Ser Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly 
            340                 345                 350         


Leu Phe 
        


<210>  61
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  61
atgggctgca cgctgagcgc cgaggacaag gcggcggtgg agcggagtaa gatgatcgac       60

cgcaacctcc gtgaggacgg cgagaaggcg gcgcgcgagg tcaagctgct gctgctcggt      120

gctggtgaat ctggtaaaag tacaattgtg aagcagatga aaattatcca tgaagctggt      180

tattcagaag aggagtgtaa acaatacaaa gcagtggtct acagtaacac catccagtca      240

attattgcta tcattagggc tatggggagg ttgaagatag actttggtga ctcagcccgg      300

gcggatgatg cacgccaact ctttgtgcta gctggagctg ctgaagaagg ctttatgact      360

gcagaacttg ctggagttat aaagagattg tggaaagata gtggtgtaca agcctgtttc      420

aacagatccc gagagtacca gcttaatgat tctgcagcat actatttgaa tgacttggac      480

agaatagctc aaccaaatta catcccgact caacaagatg ttctcagaac tagagtgaaa      540

actacaggaa ttgttgaaac ccattttact ttcaaagatc ttcattttaa aatgtttgat      600

gtgggaggtc agagatctga gcggaagaag tggattcatt gcttcgaagg agtgacggcg      660

atcatcttct gtgtagcact gagtgactac gacctggttc tagctgaaga tgaagaaatg      720

aaccgaatgc atgaaagcat gaaattgttt gacagcatat gtaacaacaa gtggtttaca      780

gatacatcca ttatactttt tctaaacaag aaggatctct ttgaagaaaa aatcaaaaag      840

agccctctca ctatatgcta tccagaatat gcaggatcaa acacatatga agaggcagct      900

gcatatattc aatgtcagtt tgaagacctc aataaaagaa aggacacaaa ggaaatatac      960

acccacttca catgtgccac agatactaag aatgtgcagt ttgtttttga tgctgtaaca     1020

gatgtcatca taaaaaataa tctaaaagat tgtggtctct tttaa                     1065


