                               SEQUENCE LISTING

<110> WYETH
 
<120> USES OF IL-22, IL-17, AND IL-1 FAMILY CYTOKINES IN AUTOIMMUNE 
      DISEASES

<130> WYT-106-PCT

<140>
<141>

<150> 61/193,087
<151> 2008-10-27

<150> 61/092,743
<151> 2008-08-28

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 1191
<212> DNA
<213> Homo sapiens

<400> 1
gaattcggcc aaagaggcct acaggttctc cttccccagt caccagttgc tcgagttaga       60

attgtctgca atggccgccc tgcagaaatc tgtgagctct ttccttatgg ggaccctggc      120

caccagctgc ctccttctct tggccctctt ggtacaggga ggagcagctg cgcccatcag      180

ctcccactgc aggcttgaca agtccaactt ccagcagccc tatatcacca accgcacctt      240

catgctggct aaggaggcta gcttggctga taacaacaca gacgttcgtc tcattgggga      300

gaaactgttc cacggagtca gtatgagtga gcgctgctat ctgatgaagc aggtgctgaa      360

cttcaccctt gaagaagtgc tgttccctca atctgatagg ttccagcctt atatgcagga      420

ggtggtgccc ttcctggcca ggctcagcaa caggctaagc acatgtcata ttgaaggtga      480

tgacctgcat atccagagga atgtgcaaaa gctgaaggac acagtgaaaa agcttggaga      540

gagtggagag atcaaagcaa ttggagaact ggatttgctg tttatgtctc tgagaaatgc      600

ctgcatttga ccagagcaaa gctgaaaaat gaataactaa ccccctttcc ctgctagaaa      660

taacaattag atgccccaaa gcgatttttt ttaaccaaaa ggaagatggg aagccaaact      720

ccatcatgat gggtggattc caaatgaacc cctgcgttag ttacaaagga aaccaatgcc      780

acttttgttt ataagaccag aaggtagact ttctaagcat agatatttat tgataacatt      840

tcattgtaac tggtgttcta tacacagaaa acaatttatt ttttaaataa ttgtcttttt      900

ccataaaaaa gattactttc cattccttta ggggaaaaaa cccctaaata gcttcatgtt      960

tccataatca gtactttata tttataaatg tatttattat tattataaga ctgcatttta     1020

tttatatcat tttattaata tggatttatt tatagaaaca tcattcgata ttgctacttg     1080

agtgtaaggc taatattgat atttatgaca ataattatag agctataaca tgtttatttg     1140

acctcaataa acacttggat atcctaaaaa aaaaaaaaaa aaagcggccg c              1191


<210> 2
<211> 179
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210> 3
<211> 1166
<212> DNA
<213> Mus sp.

<400> 3
gaattcggcc aaagaggcct acctaaacag gctctcctct cagttatcaa ctgttgacac       60

ttgtgcgatc tctgatggct gtcctgcaga aatctatgag tttttccctt atggggactt      120

tggccgccag ctgcctgctt ctcattgccc tgtgggccca ggaggcaaat gcgctgcccg      180

tcaacacccg gtgcaagctt gaggtgtcca acttccagca gccatacatc gtcaaccgca      240

cctttatgct ggccaaggag gccagccttg cagataacaa cacagatgtc cggctcatcg      300

gggagaaact gttccgagga gtcagtgcta aggatcagtg ctacctgatg aagcaggtgc      360

tcaacttcac cctggaagac gttctgctcc cccagtcaga caggttccag ccctacatgc      420

aggaggtggt gcctttcctg accaaactca gcaatcagct cagctcctgt cacatcagcg      480

gtgacgacca gaacatccag aagaatgtca gaaggctgaa ggagacagtg aaaaagcttg      540

gagagagtgg agagatcaag gcgattgggg aactggacct gctgtttatg tctctgagaa      600

atgcttgcgt ctgagcgaga agaagctaga aaacgaagaa ctgctccttc ctgccttcta      660

aaaagaacaa taagatccct gaatggactt ttttactaaa ggaaagtgag aagctaacgt      720

ccatcattat tagaagattt cacatgaaac ctggctcagt tgaaaaagaa aatagtgtca      780

agttgtccat gagaccagag gtagacttga taaccacaaa gattcattga caatatttta      840

ttgtcactga tgatacaaca gaaaaataat gtactttaaa aaattgtttg aaaggaggtt      900

acctctcatt cctttagaaa aaaagcttat gtaacttcat ttccataacc aatattttat      960

atatgtaagt ttatttatta taagtataca ttttatttat gtcagtttat taatatggat     1020

ttatttatag aaacattatc tgctattgat atttagtata aggcaaataa tatttatgac     1080

aataactatg gaaacaagat atcttaggct ttaataaaca catggatatc ataaaaaaaa     1140

aaaaaaaaaa aaaaaaaagc ggccgc                                          1166


<210> 4
<211> 179
<212> PRT
<213> Mus sp.

<400> 4
Met Ala Val Leu Gln Lys Ser Met Ser Phe Ser Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Ala Ser Cys Leu Leu Leu Ile Ala Leu Trp Ala Gln Glu Ala Asn 
            20                  25                  30          


Ala Leu Pro Val Asn Thr Arg Cys Lys Leu Glu Val Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Val Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


Arg Gly Val Ser Ala Lys Asp Gln Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Asp Val Leu Leu Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Thr Lys Leu Ser Asn Gln 
        115                 120                 125             


Leu Ser Ser Cys His Ile Ser Gly Asp Asp Gln Asn Ile Gln Lys Asn 
    130                 135                 140                 


Val Arg Arg Leu Lys Glu Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Val 
            


<210> 5
<211> 477
<212> DNA
<213> Homo sapiens

<400> 5
atggaaaaag cattgaaaat tgacacacct cagcagggga gcattcagga tatcaatcat       60

cgggtgtggg ttcttcagga ccagacgctc atagcagtcc cgaggaagga ccgtatgtct      120

ccagtcacta ttgccttaat ctcatgccga catgtggaga cccttgagaa agacagaggg      180

aaccccatct acctgggcct gaatggactc aatctctgcc tgatgtgtgc taaagtcggg      240

gaccagccca cactgcagct gaaggaaaag gatataatgg atttgtacaa ccaacccgag      300

cctgtgaagt cctttctctt ctaccacagc cagagtggca ggaactccac cttcgagtct      360

gtggctttcc ctggctggtt catcgctgtc agctctgaag gaggctgtcc tctcatcctt      420

acccaagaac tggggaaagc caacactact gactttgggt taactatgct gttttaa         477


<210> 6
<211> 158
<212> PRT
<213> Homo sapiens

<400> 6
Met Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln 
1               5                   10                  15      


Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala 
            20                  25                  30          


Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser 
        35                  40                  45              


Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr 
    50                  55                  60                  


Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly 
65                  70                  75                  80  


Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr 
                85                  90                  95      


Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser 
            100                 105                 110         


Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile 
        115                 120                 125             


Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu 
    130                 135                 140                 


Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155             


<210> 7
<211> 1172
<212> DNA
<213> Homo sapiens

<400> 7
ggttcctccc cactctgtct ttctcacctc tccttcactt ttcctagcct cctcaccacc       60

atctgatcta tcttgttctc ttcacaaaag gctctgaaga catcatgaac ccacaacggg      120

aggcagcacc caaatcctat gctattcgtg attctcgaca gatggtgtgg gtcctgagtg      180

gaaattcttt aatagcagct cctcttagcc gcagcattaa gcctgtcact cttcatttaa      240

tagcctgtag agacacagaa ttcagtgaca aggaaaaggg taatatggtt tacctgggaa      300

tcaagggaaa agatctctgt ctcttctgtg cagaaattca gggcaagcct ttaagcttca      360

gggctcccaa gataacatag ggaaggacac ttgctggaaa ctagttggaa ttcacacatg      420

cataaacctg gatgtgagag agagctgctt catgggaacc cttgaccaat ggggaatagg      480

agtgggtaga aagaagtgga agagttcctt tcaacatcac catctcagga agaaggacaa      540

agatttctca tccatgcgga ccaacatagg aatgccagga aggatgtaga aataagggga      600

ggaagattcc catctctaca atctttgagt gggtttgcta tcaatgaaat gctacaaatg      660

gaataagttg cagaaatttt tctcttttct tgggttctgg agagtttgta aaacaaggac      720

actatgtatt tttaaagagt tggtaaatct tacctgtaaa gctagagaag gtcggagtct      780

ttttaggagt agatttggac tacataacct gtaaatgtgt tttgtccagt ccttagagtg      840

ttttttaaaa aattgtaaag tcaaggtttt catgaaaaat gggaagatca gacaacattg      900

ctcctgaatt cccacagagc agcaagctac tagagctcaa tctgttattt cttttcctga      960

tgtacagggg ttaagtccta tggaagaaac agcagaatta ttcaaaatta tttacataat     1020

gtgcaattat tcactagagc atgaggagtg aaacgctctg tttagtatgt ataacttaaa     1080

aggaacacat acaattaaaa gtaattgaaa gacatttctt cttaaaaatt ctataatctt     1140

acactggtaa aataaactag tttttcccat gt                                   1172


<210> 8
<211> 164
<212> PRT
<213> Homo sapiens

<400> 8
Met Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
1               5                   10                  15      


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
            20                  25                  30          


Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys 
        35                  40                  45              


Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu 
    50                  55                  60                  


Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly 
65                  70                  75                  80  


Lys Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly 
                85                  90                  95      


Lys Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu 
            100                 105                 110         


Asp Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile 
        115                 120                 125             


Gly Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu 
    130                 135                 140                 


Arg Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met 
145                 150                 155                 160 


Pro Gly Arg Met 
                


<210> 9
<211> 1180
<212> DNA
<213> Homo sapiens

<400> 9
gagccacgat tcagtcccct ggactgtaga taaagaccct ttcttgccag gtgctgagac       60

aaccacacta tgagaggcac tccaggagac gctgatggtg gaggaagggc cgtctatcaa      120

tcaatgtgta aacctattac tgggactatt aatgatttga atcagcaagt gtggaccctt      180

cagggtcaga accttgtggc agttccacga agtgacagtg tgaccccagt cactgttgct      240

gttatcacat gcaagtatcc agaggctctt gagcaaggca gaggggatcc catttatttg      300

ggaatccaga atccagaaat gtgtttgtat tgtgagaagg ttggagaaca gcccacattg      360

cagctaaaag agcagaagat catggatctg tatggccaac ccgagcccgt gaaacccttc      420

cttttctacc gtgccaagac tggtaggacc tccacccttg agtctgtggc cttcccggac      480

tggttcattg cctcctccaa gagagaccag cccatcattc tgacttcaga acttgggaag      540

tcatacaaca ctgcctttga attaaatata aatgactgaa ctcagcctag aggtggcagc      600

ttggtctttg tcttaaagtt tctggttccc aatgtgtttt cgtctacatt ttcttagtgt      660

cattttcacg ctggtgctga gacaggggca aggctgctgt tatcatctca ttttataatg      720

aagaagaagc aattacttca tagcaactga agaacaggat gtggcctcag aagcaggaga      780

gctgggtggt ataaggctgt cctctcaagc tggtgctgtg taggccacaa ggcatctgca      840

tgagtgactt taagactcaa agaccaaaca ctgagctttc ttctaggggt gggtatgaag      900

atgcttcaga gctcatgcgc gttacccacg atggcatgac tagcacagag ctgatctctg      960

tttctgtttt gctttattcc ctcttgggat gatatcatcc agtctttata tgttgccaat     1020

atacctcatt gtgtgtaata gaaccttctt agcattaaga ccttgtaaac aaaaataatt     1080

cttgtgttaa gttaaatcat ttttgtccta attgtaatgt gtaatcttaa agttaaataa     1140

actttgtgta tttatataat aataaagcta aaactgatat                           1180


<210> 10
<211> 169
<212> PRT
<213> Homo sapiens

<400> 10
Met Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val Tyr 
1               5                   10                  15      


Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln 
            20                  25                  30          


Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser 
        35                  40                  45              


Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro 
    50                  55                  60                  


Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln 
65                  70                  75                  80  


Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr 
                85                  90                  95      


Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu 
            100                 105                 110         


Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser 
        115                 120                 125             


Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys 
    130                 135                 140                 


Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn 
145                 150                 155                 160 


Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 


<210> 11
<211> 1964
<212> DNA
<213> Homo sapiens

<400> 11
cccgcccacg gtggcgggga aatacctagg catggaagtg gcatgacagg gctcgtgtcc       60

ctgtcatatt ttccactctc cacgaggtcc tgcgcgcttc aatcctgcag gcagcccggt      120

ttggggatgt ggtccttgct gctctgcggg ttgtccatcg cccttccact gtctgtcaca      180

gcagatggat gcaaggacat ttttatgaaa aatgagatac tttcagcaag ccagcctttt      240

gcttttaatt gtacattccc tcccataaca tctggggaag tcagtgtaac atggtataaa      300

aattctagca aaatcccagt gtccaaaatc atacagtcta gaattcacca ggacgagact      360

tggattttgt ttctccccat ggaatggggg gactcaggag tctaccaatg tgttataaag      420

ggtagagaca gctgtcatag aatacatgta aacctaactg tttttgaaaa acattggtgt      480

gacacttcca taggtggttt accaaattta tcagatgagt acaagcaaat attacatctt      540

ggaaaagatg atagtctcac atgtcatctg cacttcccga agagttgtgt tttgggtcca      600

ataaagtggt ataaggactg taacgagatt aaaggggagc ggttcactgt tttggaaacc      660

aggcttttgg tgagcaatgt ctcggcagag gacagaggga actacgcgtg tcaagccata      720

ctgacacact cagggaagca gtacgaggtt ttaaatggca tcactgtgag cattacagaa      780

agagctggat atggaggaag tgtccctaaa atcatttatc caaaaaatca ttcaattgaa      840

gtacagcttg gtaccactct gattgtggac tgcaatgtaa cagacaccaa ggataataca      900

aatctacgat gctggagagt caataacact ttggtggatg attactatga tgaatccaaa      960

cgaatcagag aaggggtgga aacccatgtc tcttttcggg aacataattt gtacacagta     1020

aacatcacct tcttggaagt gaaaatggaa gattatggcc ttcctttcat gtgccacgct     1080

ggagtgtcca cagcatacat tatattacag ctcccagctc cggattttcg agcttacttg     1140

ataggagggc ttatcgcctt ggtggctgtg gctgtgtctg ttgtgtacat atacaacatt     1200

tttaagatcg acattgttct ttggtatcga agtgccttcc attctacaga gaccatagta     1260

gatgggaagc tgtatgacgc ctatgtctta taccccaagc cccacaagga aagccagagg     1320

catgccgtgg atgccctggt gttgaatatc ctgcccgagg tgttggagag acaatgtgga     1380

tataagttgt ttatattcgg cagagatgaa ttccctggac aagccgtggc caatgtcatc     1440

gatgaaaacg ttaagctgtg caggaggctg attgtcattg tggtccccga atcgctgggc     1500

tttggcctgt tgaagaacct gtcagaagaa caaatcgcgg tctacagtgc cctgatccag     1560

gacgggatga aggttattct cattgagctg gagaaaatcg aggactacac agtcatgcca     1620

gagtcaattc agtacatcaa acagaagcat ggtgccatcc ggtggcatgg ggacttcacg     1680

gagcagtcac agtgtatgaa gaccaagttt tggaagacag tgagatacca catgccgccc     1740

agaaggtgtc ggccgtttcc tccggtccag ctgctgcagc acacaccttg ctaccgcacc     1800

gcaggcccag aactaggctc aagaagaaag aagtgtactc tcacgactgg ctaagacttg     1860

ctggactgac acctatggct ggaagatgac ttgttttgct ccatgtctcc tcattcctac     1920

acctattttc tgctgcagga tgaggctagg gttagcattc taga                      1964


<210> 12
<211> 575
<212> PRT
<213> Homo sapiens

<400> 12
Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu 
                165                 170                 175     


Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn 
            180                 185                 190         


Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val 
        195                 200                 205             


Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly 
    210                 215                 220                 


Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln 
225                 230                 235                 240 


Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp 
                245                 250                 255     


Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp 
            260                 265                 270         


Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val 
        275                 280                 285             


Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu 
    290                 295                 300                 


Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val 
305                 310                 315                 320 


Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala 
                325                 330                 335     


Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val 
            340                 345                 350         


Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp 
    370                 375                 380                 


Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala 
385                 390                 395                 400 


Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln 
                405                 410                 415     


Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln 
            420                 425                 430         


Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu 
        435                 440                 445             


Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn 
    450                 455                 460                 


Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly 
465                 470                 475                 480 


Met Lys Val Ile Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val 
                485                 490                 495     


Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg 
            500                 505                 510         


Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe 
        515                 520                 525             


Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe 
    530                 535                 540                 


Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
                565                 570                 575 


<210> 13
<211> 1859
<212> DNA
<213> Homo sapiens

<400> 13
gcaggcacaa actcatccat ccccagttga ttggaagaaa caacgatgac tcctgggaag       60

acctcattgg tgtcactgct actgctgctg agcctggagg ccatagtgaa ggcaggaatc      120

acaatcccac gaaatccagg atgcccaaat tctgaggaca agaacttccc ccggactgtg      180

atggtcaacc tgaacatcca taaccggaat accaatacca atcccaaaag gtcctcagat      240

tactacaacc gatccacctc accttggaat ctccaccgca atgaggaccc tgagagatat      300

ccctctgtga tctgggaggc aaagtgccgc cacttgggct gcatcaacgc tgatgggaac      360

gtggactacc acatgaactc tgtccccatc cagcaagaga tcctggtcct gcgcagggag      420

cctccacact gccccaactc cttccggctg gagaagatac tggtgtccgt gggctgcacc      480

tgtgtcaccc cgattgtcca ccatgtggcc taagagctct ggggagccca cactccccaa      540

agcagttaga ctatggagag ccgacccagc ccctcaggaa ccctcatcct tcaaagacag      600

cctcatttcg gactaaactc attagagttc ttaaggcagt ttgtccaatt aaagcttcag      660

aggtaacact tggccaagat atgagatctg aattaccttt ccctctttcc aagaaggaag      720

gtttgactga gtaccaattt gcttcttgtt tactttttta agggctttaa gttatttatg      780

tatttaatat gccctgagat aactttgggg tataagattc cattttaatg aattacctac      840

tttattttgt ttgtcttttt aaagaagata agattctggg cttgggaatt ttattattta      900

aaaggtaaaa cctgtattta tttgagctat ttaaggatct atttatgttt aagtatttag      960

aaaaaggtga aaaagcacta ttatcagttc tgcctaggta aatgtaagat agaattaaat     1020

ggcagtgcaa aatttctgag tctttacaac atacggatat agtatttcct cctctttgtt     1080

tttaaaagtt ataacatggc tgaaaagaaa gattaaacct actttcatat gtattaattt     1140

aaattttgca atttgttgag gttttacaag agatacagca agtctaactc tctgttccat     1200

taaaccctta taataaaatc cttctgtaat aataaagttt caaaagaaaa tgtttatttg     1260

ttctcattaa atgtatttta gcaaactcag ctcttcccta ttgggaagag ttatgcaaat     1320

tctcctataa gcaaaacaaa gcatgtcttt gagtaacaat gacctggaaa tacccaaaat     1380

tccaagttct cgatttcaca tgccttcaag actgaacacc gactaaggtt ttcatactat     1440

tagccaatgc tgtagacaga agcattttga taggaataga gcaaataaga taatggccct     1500

gaggaatggc atgtcattat taaagatcat atggggaaaa tgaaaccctc cccaaaatac     1560

aagaagttct gggaggagac attgtcttca gactacaatg tccagtttct cccctagact     1620

caggcttcct ttggagatta aggcccctca gagatcaaca gaccaacatt tttctcttcc     1680

tcaagcaaca ctcctagggc ctggcttctg tctgatcaag gcaccacaca acccagaaag     1740

gagctgatgg ggcagaacga actttaagta tgagaaaagt tcagcccaag taaaataaaa     1800

actcaatcac attcaattcc agagtagttt caagtttcac atcgtaacca ttttcgccc      1859


<210> 14
<211> 155
<212> PRT
<213> Homo sapiens

<400> 14
Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


