                         SEQUENCE LISTING

<110> Horak, Ivan
      Sapra, Puja

<120>  METHOD OF TREATING RAS ASSOCIATED CANCER

<130>  213.1320-PCT

<140>  
<141>  

<150>  61/093,044
<151>  08-29-2008

<160>  7     

<170>  PatentIn version 3.1

<210>  1
<211>  189
<212>  PRT
<213>  human

<400>  1

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  2
<211>  188
<212>  PRT
<213>  human

<400>  2

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  3
<211>  189
<212>  PRT
<213>  human

<400>  3

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  4
<211>  189
<212>  PRT
<213>  human

<400>  4

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  5
<211>  567
<212>  DNA
<213>  human

<400>  5
atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg     60

atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga ggattcctac    120

aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt    180

caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg ctttctttgt    240

gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt    300

aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa atgtgatttg    360

ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta tggaattcct    420

tttattgaaa catcagcaaa gacaagacag ggtgttgatg atgccttcta tacattagtt    480

cgagaaattc gaaaacataa agaaaagatg agcaaagatg gtaaaaagaa gaaaaagaag    540

tcaaagacaa agtgtgtaat tatgtaa                                        567


<210>  6
<211>  570
<212>  DNA
<213>  human

<400>  6
atgacggaat ataagctggt ggtggtgggc gccggcggtg tgggcaagag tgcgctgacc     60

atccagctga tccagaacca ttttgtggac gaatacgacc ccactataga ggattcctac    120

cggaagcagg tggtcattga tggggagacg tgcctgttgg acatcctgga taccgccggc    180

caggaggagt acagcgccat gcgggaccag tacatgcgca ccggggaggg cttcctgtgt    240

gtgtttgcca tcaacaacac caagtctttt gaggacatcc accagtacag ggagcagatc    300

aaacgggtga aggactcgga tgacgtgccc atggtgctgg tggggaacaa gtgtgacctg    360

gctgcacgca ctgtggaatc tcggcaggct caggacctcg cccgaagcta cggcatcccc    420

tacatcgaga cctcggccaa gacccggcag ggagtggagg atgccttcta cacgttggtg    480

cgtgagatcc ggcagcacaa gctgcggaag ctgaaccctc ctgatgagag tggccccggc    540

tgcatgagct gcaagtgtgt gctctcctga                                     570


<210>  7
<211>  570
<212>  DNA
<213>  human

<400>  7
atgacggaat ataagctggt ggtggtgggc gccggcggtg tgggcaagag tgcgctgacc     60

atccagctga tccagaacca ttttgtggac gaatacgacc ccactataga ggattcctac    120

cggaagcagg tggtcattga tggggagacg tgcctgttgg acatcctgga taccgccggc    180

caggaggagt acagcgccat gcgggaccag tacatgcgca ccggggaggg cttcctgtgt    240

gtgtttgcca tcaacaacac caagtctttt gaggacatcc accagtacag ggagcagatc    300

aaacgggtga aggactcgga tgacgtgccc atggtgctgg tggggaacaa gtgtgacctg    360

gctgcacgca ctgtggaatc tcggcaggct caggacctcg cccgaagcta cggcatcccc    420

tacatcgaga cctcggccaa gacccggcag ggagtggagg atgccttcta cacgttggtg    480

cgtgagatcc ggcagcacaa gctgcggaag ctgaaccctc ctgatgagag tggccccggc    540

tgcatgagct gcaagtgtgt gctctcctga                                     570


