                         SEQUENCE LISTING

<110>  CODEXIS, Inc.
       MUNDORFF, Emily
       DEVRIES, Erik
       
 
<120>  KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF 
       (4S)-3-[(5S)-5-(4-FLUROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3- 
       OXAZOLIDIN-2-ONE

<130>  CX2-025 (376247-021USP1)

<150>  61/092,807
<151>  2008-08-29

<160>  165   

<170>  PatentIn version 3.5

<210>  1
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized L. Brevis Sequence

<400>  1
atgtctaacc gtctggatgg caaagtagcc atcattaccg gcgggactct gggtatcggt       60

ttggcaatcg ccacgaaatt tgtagaggag ggtgcgaaag taatgattac tggtcgtcac      120

tccgatgtag gtgaaaaggc cgccaaatca gtaggcactc cggatcagat tcagtttttt      180

cagcacgatt catccgatga agatggctgg acgaaactgt tcgacgccac cgagaaagca      240

ttcggcccgg ttagcacctt agtgaacaat gcagggattg cagttaacaa aagcgttgaa      300

gaaactacca cggccgaatg gcgtaaactg ctggccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgaggggtt cgtaggcgat ccgagcctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctat atcaagaccc cgctggtcga tgatctgccg      600

ggtgctgagg aagcgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catatatctg tgtgtacctg gcatctaatg aatcgaaatt tgcgacgggt      720

tccgaatttg tggtcgacgg cgggtatacc gcacagtaat ga                         762


<210>  2
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of Codon Optimized L. Brevis Sequence

<400>  2

Met Ser Asn Arg Leu Asp Gly Lys Val Ala Ile Ile Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Met Ile Thr Gly Arg His Ser Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Val Gly Thr Pro Asp Gln Ile Gln Phe Phe Gln His Asp Ser 
    50                  55                  60                  


Ser Asp Glu Asp Gly Trp Thr Lys Leu Phe Asp Ala Thr Glu Lys Ala 
65                  70                  75                  80  


Phe Gly Pro Val Ser Thr Leu Val Asn Asn Ala Gly Ile Ala Val Asn 
                85                  90                  95      


Lys Ser Val Glu Glu Thr Thr Thr Ala Glu Trp Arg Lys Leu Leu Ala 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Phe Val Gly Asp Pro Ser Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Tyr Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Pro Gly Ala Glu Glu Ala Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Tyr Ile Cys Val Tyr Leu Ala Ser Asn Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  3
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized L. Kefir Sequence

<400>  3
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgaggggtt cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctat atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  4
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of Codon Optimized L. kefir Sequence

<400>  4

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Tyr Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  5
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  5
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgaggggtt cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgc atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgagccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtacacc gcacagtga                             759


<210>  6
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  6

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  7
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  7
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgacgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  8
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  8

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  9
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  9
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgaggggct ggtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  10
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  10

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Leu Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  11
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  11
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggacact gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgttaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttctggggtt cgtaggcgat ccgacgacgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catgggtctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtggacc gcacagtga                             759


<210>  12
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  12

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Leu Gly Phe Val Gly Asp Pro Thr Thr Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Leu Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln 
                245                 250         


<210>  13
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  13
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggacact gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcgt      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgttaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttttcgggat ggtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgattgggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catgggtctg tgtgtacctg gcatctgatg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtggacc gcacagtga                             759


<210>  14
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  14

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Phe Gly Met Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Leu Asp Asp Trp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln 
                245                 250         


<210>  15
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  15
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggacact gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcgc      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgttaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttttcgggat ggtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa      600

ggtgctgagg aaatgttttc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catgggtctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtggacc gcacagtga                             759


<210>  16
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  16

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Phe Gly Met Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Leu Asp Asp Leu Glu Gly Ala Glu Glu Met Phe Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln 
                245                 250         


<210>  17
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  17
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggacact gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgttaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttttcgggat ggtaggcgat ccgactaccg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catgggtctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtggacc gcacagtga                             759


<210>  18
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  18

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Phe Gly Met Val Gly Asp Pro Thr Thr Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Leu Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln 
                245                 250         


<210>  19
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  19
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggacact gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgttaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttttcgggat ggtaggcgat ccgactaccg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgatgctcga tgattatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catgggtctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtggacc gcacagtga                             759


<210>  20
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  20

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Phe Gly Met Val Gly Asp Pro Thr Thr Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Met Leu Asp Asp Tyr Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln 
                245                 250         


<210>  21
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  21
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggacact gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgttaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttttcgggat ggtaggcgat ccgtctaccg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catgggtctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtggacc gcacagtga                             759


<210>  22
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  22

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Phe Gly Met Val Gly Asp Pro Ser Thr Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Leu Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln 
                245                 250         


<210>  23
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  23
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggacact gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgttaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttttcgggat ggtaggcgat ccgtctctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgatgctcga tgatctggaa      600

ggtgctgagg aaatgttttc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catgggtctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtggacc gcacagtga                             759


<210>  24
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  24

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Phe Gly Met Val Gly Asp Pro Ser Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Met Leu Asp Asp Leu Glu Gly Ala Glu Glu Met Phe Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln 
                245                 250         


<210>  25
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  25
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggacact gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcgc      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgttaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttttcgggat ggtaggcgat ccgactaccg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catgggtctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtggacc gcacagtga                             759


<210>  26
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  26

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Phe Gly Met Val Gly Asp Pro Thr Thr Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Leu Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln 
                245                 250         


<210>  27
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  27
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgcggggct ggtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgc atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  28
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  28

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ala Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  29
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  29
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgaggggct cgtaggcgat ccgacgggcg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggccct atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  30
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  30

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Leu Val Gly Asp Pro Thr Gly Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  31
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  31
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggccct atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  32
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  32

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  33
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  33
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttagtgggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggccct atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  34
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  34

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  35
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  35
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttcaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggcgca atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  36
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  36

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Gln Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Ala Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  37
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  37
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggccct atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg ctgaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  38
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  38

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Leu Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  39
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  39
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttgaggggct cgtaggcgat ccgacgcagg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggccct atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  40
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  40

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Leu Val Gly Asp Pro Thr Gln Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  41
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  41
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gtgtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgacgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  42
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  42

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  43
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  43
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaac      420

atgagcagta tcagtgggtt cgtaggcgat ccgacgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  44
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  44

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  45
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  45
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgacgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  46
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  46

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  47
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  47
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgacgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatctggaa      600

ggtggggagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  48
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  48

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Gly Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  49
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  49
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgcta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgacgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  50
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  50

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Ala Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  51
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  51
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgaagctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  52
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  52

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Lys Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  53
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  53
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  54
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  54

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  55
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  55
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatta gtgttcaaaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgacgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  56
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  56

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  57
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  57
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgacgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc agctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  58
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  58

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Gln Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  59
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  59
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatta gtgttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgaagctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  60
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  60

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Lys Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  61
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  61
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggatta gtgttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  62
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  62

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ser Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  63
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  63
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  64
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  64

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  65
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  65
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttaataa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  66
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  66

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Asn 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  67
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  67
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc ggctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  68
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  68

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Arg Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  69
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  69
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  70
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  70

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  71
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  71
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc ggctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  72
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  72

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Arg Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  73
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  73
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttactaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc ggctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  74
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  74

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Arg Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  75
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  75
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccactaaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcaacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc gcctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  76
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  76

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asn Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Arg Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  77
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  77
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  78
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  78

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  79
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  79
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccgt      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacac tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  80
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  80

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  81
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  81
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccactaaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cattgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgaagatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  82
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  82

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Glu Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  83
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  83
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccactaaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cattgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc ctctggtcga ggatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  84
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  84

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Glu Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  85
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  85
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccactaaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg caatgcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc gtctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  86
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  86

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Met Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Arg Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  87
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  87
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  88
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  88

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  89
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  89
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagcgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  90
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  90

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  91
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  91
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  92
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  92

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  93
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  93
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcgata ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcgatac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  94
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  94

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Asp Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Ile Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  95
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  95
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cacttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  96
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  96

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Leu Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  97
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  97
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gaacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  98
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  98

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Asn Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  99
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  99
atgactgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

caacacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

ggcactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt agtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  100
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  100

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Gly Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  101
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  101
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggatgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa gagcgttgaa      300

gacactacca cggaggaatg gcacaaactg atgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  102
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  102

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Met Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  103
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  103
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgacac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactatgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatatc gcacagtga                             759


<210>  104
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  104

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Ile Ala Gln 
                245                 250         


<210>  105
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  105
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtaggtgag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgag      300

aacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  106
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  106

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Gly Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asn Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  107
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  107
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  108
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  108

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  109
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  109
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctggatgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tggtgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  110
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  110

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Asp 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Gly Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  111
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  111
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gtctaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  112
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  112

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Ser Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  113
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  113
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcgggtgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattcg ccgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc gtctggtcga tgacgatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  114
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  114

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Gly Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Arg Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Arg Leu Val Asp Asp Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  115
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  115
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttcgcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatgg cgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga tgatgatgaa      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  116
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  116

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Phe Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  117
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  117
atgaccaacc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagccgag ggtgcgaaag tagttattac tggtcgccac      120

gcgggtgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cgggggaatg gcacaaactg ttgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcgt taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  118
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  118

Met Thr Asn Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Ala Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Gly Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Gly Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Val Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  119
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  119
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcgggtgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcgattc gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatgag      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  120
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  120

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Gly Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Ile Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  121
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  121
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagccgag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggtt cgtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcgattc gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggtgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  122
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  122

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Ala Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Ile Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  123
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  123
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgccac      120

gcgggtgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcgattc gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatgag      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaaccg      660

aatgacgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  124
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  124

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Gly Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Ile Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  125
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  125
atgaccgatc gtctgaagag caaagtagcc atcgtaaccg gcgggaccca gggtatcggt       60

ttggcaatcg ccgataaatt tgtagccgag ggtgcgaaag tagttattac tggtcgccac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggta ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttcagaa aagcgttgaa      300

gacactacca cggaggaatg gcacaaactg ctgtccgtta atctggatag tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaag aataaaggct tgggcgctag catcatcaat      420

atgagcagta tcagtgggct ggtaggcgat ccgatgctgg gggcatacaa tgcttccaag      480

ggggcgattc gtatcatgtc gaaaagcgca gcgctggatt gcgcagtgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgt atcaagaccc cgctggtcga taaagatcca      600

ggtgctgagg aaatgatgtc acagcgtacg agaaccccta tgggccacat tggcgaacca      660

aacgatgtgg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  126
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  126

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Ala Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Gln 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Leu Val Gly Asp Pro Met Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Ile Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Val 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Lys Asp Pro Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  127
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. Brevis

<400>  127
atgtctaacc gtctggatgg caaagtagcc atcattaccg gcgggactct gggtatcggt       60

ttggcaatcg ccacgaaatt tgtagaggag ggtgcgaaag taatgattac tggtcgtcac      120

tccgatgtag gtgaaaaggc cgccaaatca gtaggcactc cggatcagat tcagtttttt      180

cagcacgatt catccgatga agatggctgg acgaaactgt tcgacgccac cgagaaagca      240

ttcggcccgg ttagcacctt agtgaacaat gcagggattg cagttaacaa aagcgttgaa      300

gaaactacca cggccgaatg gcgtaaactg ctggccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttagcgggtt cgtaggcgat ccgagcctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgc atcaagaccc cgctggtcga tgatctgccg      600

ggtgctgagg aagcgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catatatctg tgtgtacctg gcatctaatg aatcgaaatt tgcgacgggt      720

tccgaatttg tggtcgacgg cgggtatacc gcacagtaat ga                         762


<210>  128
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. brevis

<400>  128

Met Ser Asn Arg Leu Asp Gly Lys Val Ala Ile Ile Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Met Ile Thr Gly Arg His Ser Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Val Gly Thr Pro Asp Gln Ile Gln Phe Phe Gln His Asp Ser 
    50                  55                  60                  


Ser Asp Glu Asp Gly Trp Thr Lys Leu Phe Asp Ala Thr Glu Lys Ala 
65                  70                  75                  80  


Phe Gly Pro Val Ser Thr Leu Val Asn Asn Ala Gly Ile Ala Val Asn 
                85                  90                  95      


Lys Ser Val Glu Glu Thr Thr Thr Ala Glu Trp Arg Lys Leu Leu Ala 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Ser Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Pro Gly Ala Glu Glu Ala Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Tyr Ile Cys Val Tyr Leu Ala Ser Asn Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  129
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of L. Kefir

<400>  129
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt       60

ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac      120

gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc      180

cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca      240

ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa      300

gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc      360

ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat      420

atgagcagta ttagcgggtt cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag      480

ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat      540

gtgcgtgtca acacagtaca tccgggctgc atcaagaccc cgctggtcga tgatctggaa      600

ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg      660

aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt      720

gcagaatttg tggtcgacgg cgggtatacc gcacagtga                             759


<210>  130
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  130

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  131
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Candida magnoliae

<400>  131
atggcaaaga attttagcaa tgtagagtat cccgcacccc cccccgcaca tacaaagaat       60

gagagcttac aagtattaga tttatttaag ttaaatggaa aagtagcaag cataacagga      120

agcagcagcg gaataggata tgcattagca gaggcttttg cacaagtcgg agcagatgta      180

gcaatatggt ataatagcca tgatgcaaca ggaaaagcag aggcattagc aaagaagtat      240

ggagtaaagg taaaggcata taaagcaaat gtaagcagca gcgatgcagt caagcaaaca      300

atagagcaac aaataaagga ttttggacat ttagatatag tagtagcaaa tgcaggaata      360

ccctggacaa agggagcata tatagatcaa gatgatgaca agcattttga ccaagtagta      420

gatgtagact taaagggagt aggatacgta gcaaagcatg caggaaggca ttttagggaa      480

aggtttgaga aagagggaaa aaagggagca ttagtattta cagcaagcat gagcggacat      540

atagtaaatg tcccccaatt ccaagcaaca tataatgcag caaaggcagg agtaaggcat      600

tttgcaaaga gcttagcagt cgagtttgca ccctttgcaa gggtaaatag cgtaagcccc      660

ggatatataa atacagagat aagcgatttc gtcccccaag agacacaaaa taagtggtgg      720

agcttagtcc ccttaggaag gggaggagag acagcagagt tagtaggagc atatttattc      780

ttagcaagcg atgcaggaag ctatgcaaca ggaacagata taatagtaga tggaggatat      840

acattaccct aa                                                          852


<210>  132
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Candida magnoliae

<400>  132

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  133
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Rhodococcus erythropolis

<400>  133
atgaaagcca ttcagtacac tcgtatcggt gcggaaccag aactgactga aatcccgaag       60

ccggaaccgg gcccgggcga agtactgctg gaagtcacgg cagctggcgt gtgccattcc      120

gatgatttca ttatgtctct gccggaagaa cagtacacct acggcctgcc gctgaccctg      180

ggtcatgaag gtgctggtaa agttgccgca gttggcgaag gtgttgaagg gttggatatt      240

ggcaccaatg tggttgtgta cggcccatgg ggttgtggca actgttggca ttgcagtcag      300

ggcctggaga actattgctc ccgtgcgcag gaactgggta ttaacccgcc tggtctgggt      360

gctccggggg ctttggcaga atttatgatt gtcgactcac cacgtcattt ggtcccgatt      420

ggcgatttag accctgttaa aactgttccg ttgactgatg cgggcctgac cccataccat      480

gcaatcaaac gctccctgcc gaaactgcgc ggcggctctt atgcagtagt gatcggtacg      540

ggtggcctgg gccacgtggc tatccaactg ctgcgtcatt tatctgctgc aacggtgatc      600

gccttggacg tttctgccga taaactggaa ctggctacca aagtcggcgc acatgaagta      660

gtcctgtctg ataaagatgc agcggagaat gtgcgtaaaa ttactggtag ccaaggtgca      720

gctttggtgt tggattttgt gggctatcag cctaccattg acaccgccat ggcagtggcg      780

ggcgtgggct ctgacgtcac cattgttggt atcggtgatg gccaggcaca tgcgaaagtt      840

ggtttcttcc agagtcctta tgaggcatcg gttacggtac cttattgggg cgctcgtaat      900

gaactgatcg aattgatcga tctggcgcat gctggtattt tcgacattgc cgttgagacc      960

ttctctttgg ataatggtgc agaggcctat cgtcgcctgg ctgcgggcac actgtcaggc     1020

cgtgcggtag tcgtcccggg cctgtaa                                         1047


<210>  134
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Rhodococcus erythropolis

<400>  134

Met Lys Ala Ile Gln Tyr Thr Arg Ile Gly Ala Glu Pro Glu Leu Thr 
1               5                   10                  15      


Glu Ile Pro Lys Pro Glu Pro Gly Pro Gly Glu Val Leu Leu Glu Val 
            20                  25                  30          


Thr Ala Ala Gly Val Cys His Ser Asp Asp Phe Ile Met Ser Leu Pro 
        35                  40                  45              


Glu Glu Gln Tyr Thr Tyr Gly Leu Pro Leu Thr Leu Gly His Glu Gly 
    50                  55                  60                  


Ala Gly Lys Val Ala Ala Val Gly Glu Gly Val Glu Gly Leu Asp Ile 
65                  70                  75                  80  


Gly Thr Asn Val Val Val Tyr Gly Pro Trp Gly Cys Gly Asn Cys Trp 
                85                  90                  95      


His Cys Ser Gln Gly Leu Glu Asn Tyr Cys Ser Arg Ala Gln Glu Leu 
            100                 105                 110         


Gly Ile Asn Pro Pro Gly Leu Gly Ala Pro Gly Ala Leu Ala Glu Phe 
        115                 120                 125             


Met Ile Val Asp Ser Pro Arg His Leu Val Pro Ile Gly Asp Leu Asp 
    130                 135                 140                 


Pro Val Lys Thr Val Pro Leu Thr Asp Ala Gly Leu Thr Pro Tyr His 
145                 150                 155                 160 


Ala Ile Lys Arg Ser Leu Pro Lys Leu Arg Gly Gly Ser Tyr Ala Val 
                165                 170                 175     


Val Ile Gly Thr Gly Gly Leu Gly His Val Ala Ile Gln Leu Leu Arg 
            180                 185                 190         


His Leu Ser Ala Ala Thr Val Ile Ala Leu Asp Val Ser Ala Asp Lys 
        195                 200                 205             


Leu Glu Leu Ala Thr Lys Val Gly Ala His Glu Val Val Leu Ser Asp 
    210                 215                 220                 


Lys Asp Ala Ala Glu Asn Val Arg Lys Ile Thr Gly Ser Gln Gly Ala 
225                 230                 235                 240 


Ala Leu Val Leu Asp Phe Val Gly Tyr Gln Pro Thr Ile Asp Thr Ala 
                245                 250                 255     


Met Ala Val Ala Gly Val Gly Ser Asp Val Thr Ile Val Gly Ile Gly 
            260                 265                 270         


Asp Gly Gln Ala His Ala Lys Val Gly Phe Phe Gln Ser Pro Tyr Glu 
        275                 280                 285             


Ala Ser Val Thr Val Pro Tyr Trp Gly Ala Arg Asn Glu Leu Ile Glu 
    290                 295                 300                 


Leu Ile Asp Leu Ala His Ala Gly Ile Phe Asp Ile Ala Val Glu Thr 
305                 310                 315                 320 


Phe Ser Leu Asp Asn Gly Ala Glu Ala Tyr Arg Arg Leu Ala Ala Gly 
                325                 330                 335     


Thr Leu Ser Gly Arg Ala Val Val Val Pro Gly Leu 
            340                 345             


<210>  135
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YGL ADH from Saccharomyces cervisiae

<400>  135
atgaccacgg aaaaaaccgt agtgttcgtg tcaggcgcga ccggttttat tgctctgcac       60

gtggtagatg acctgctgaa aactggttac aaagtaattg gttccggtcg ttctcaggaa      120

aaaaatgacg gtttgctgaa gaagttcaag tccaacccga atctgagcat ggaaattgtg      180

gaagatattg cggcaccaaa cgccttcgat aaagtattcc agaaacatgg taaagaaatt      240

aaagtggtcc tgcatatcgc gtccccggtc catttcaaca ctaccgattt cgaaaaagac      300

ttactgatcc cggcggtaaa cggtaccaaa tctattttgg aagcaattaa gaactatgcc      360

gcagacaccg tggaaaaagt ggttattact tcatctgttg ccgcgttggc ctctccgggt      420

gatatgaaag ataccagctt cgtggttaac gaagaatcct ggaataaaga cacctgggaa      480

tcgtgtcagg cgaatgctgt gtccgcttat tgcggttcta aaaaattcgc agagaaaacg      540

gcgtgggact tcttggaaga aaaccagagc agcattaaat ttactctgtc cacgattaac      600

ccaggcttcg tttttggtcc gcagctgttc gccgactcct tgcgcaatgg tattaactct      660

agcagtgcga ttattgcgaa cctggtgtcg tataaattag gggataactt ctacaattat      720

agcggcccgt ttatcgacgt ccgtgacgtt tccaaagctc atctgctggc atttgagaaa      780

cctgaatgcg ccggtcagcg cctgtttctg tgcgaggata tgttctgttc ccaggaagcc      840

ctggacattc tgaacgaaga atttccacag ctgaagggca agatcgcaac gggcgaacct      900

ggcagcggct cgaccttcct gactaaaaat tgttgcaaat gcgacaatcg taaaactaaa      960

aacttgctgg gcttccagtt caacaaattc cgcgactgca ttgtcgatac tgcgtcccag     1020

ttgctggaag tgcaaagcaa aagctaa                                         1047


<210>  136
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGL ADH from Saccharomyces cervisiae

<400>  136

Met Thr Thr Glu Lys Thr Val Val Phe Val Ser Gly Ala Thr Gly Phe 
1               5                   10                  15      


Ile Ala Leu His Val Val Asp Asp Leu Leu Lys Thr Gly Tyr Lys Val 
            20                  25                  30          


Ile Gly Ser Gly Arg Ser Gln Glu Lys Asn Asp Gly Leu Leu Lys Lys 
        35                  40                  45              


Phe Lys Ser Asn Pro Asn Leu Ser Met Glu Ile Val Glu Asp Ile Ala 
    50                  55                  60                  


Ala Pro Asn Ala Phe Asp Lys Val Phe Gln Lys His Gly Lys Glu Ile 
65                  70                  75                  80  


Lys Val Val Leu His Ile Ala Ser Pro Val His Phe Asn Thr Thr Asp 
                85                  90                  95      


Phe Glu Lys Asp Leu Leu Ile Pro Ala Val Asn Gly Thr Lys Ser Ile 
            100                 105                 110         


Leu Glu Ala Ile Lys Asn Tyr Ala Ala Asp Thr Val Glu Lys Val Val 
        115                 120                 125             


Ile Thr Ser Ser Val Ala Ala Leu Ala Ser Pro Gly Asp Met Lys Asp 
    130                 135                 140                 


Thr Ser Phe Val Val Asn Glu Glu Ser Trp Asn Lys Asp Thr Trp Glu 
145                 150                 155                 160 


Ser Cys Gln Ala Asn Ala Val Ser Ala Tyr Cys Gly Ser Lys Lys Phe 
                165                 170                 175     


Ala Glu Lys Thr Ala Trp Asp Phe Leu Glu Glu Asn Gln Ser Ser Ile 
            180                 185                 190         


Lys Phe Thr Leu Ser Thr Ile Asn Pro Gly Phe Val Phe Gly Pro Gln 
        195                 200                 205             


Leu Phe Ala Asp Ser Leu Arg Asn Gly Ile Asn Ser Ser Ser Ala Ile 
    210                 215                 220                 


Ile Ala Asn Leu Val Ser Tyr Lys Leu Gly Asp Asn Phe Tyr Asn Tyr 
225                 230                 235                 240 


Ser Gly Pro Phe Ile Asp Val Arg Asp Val Ser Lys Ala His Leu Leu 
                245                 250                 255     


Ala Phe Glu Lys Pro Glu Cys Ala Gly Gln Arg Leu Phe Leu Cys Glu 
            260                 265                 270         


Asp Met Phe Cys Ser Gln Glu Ala Leu Asp Ile Leu Asn Glu Glu Phe 
        275                 280                 285             


Pro Gln Leu Lys Gly Lys Ile Ala Thr Gly Glu Pro Gly Ser Gly Ser 
    290                 295                 300                 


Thr Phe Leu Thr Lys Asn Cys Cys Lys Cys Asp Asn Arg Lys Thr Lys 
305                 310                 315                 320 


Asn Leu Leu Gly Phe Gln Phe Asn Lys Phe Arg Asp Cys Ile Val Asp 
                325                 330                 335     


Thr Ala Ser Gln Leu Leu Glu Val Gln Ser Lys Ser 
            340                 345             


<210>  137
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YDL ADH from Saccharomyces cervisiae

<400>  137
atgtcttttc accaacagtt tttcacgctg aacaacggca ataaaatccc ggcgattgcc       60

atcatcggca ctggtacacg ttggtataaa aatgaagaaa ctgacgcgac cttctccaat      120

agtctggttg aacaaatcgt gtatgcgttg aaactgccgg ggattatcca catcgacgcc      180

gcggagattt atcgcaccta cccggaagtg ggtaaagcac tgtccctgac cgaaaagcct      240

cgtaacgcga tttttctgac ggataaatat tctccgcaga ttaaaatgag tgactcccct      300

gcggacggtc tggatttagc attgaagaaa atgggtacag attatgttga tttatatctg      360

ttacattccc cgtttgtttc gaaggaagtg aatggcttaa gcttagaaga ggcttggaaa      420

gatatggagc agttatacaa aagtggtaaa gctaaaaaca tcggggtttc caatttcgca      480

gtggaagacc tgcaacgtat cctgaaagtc gctgaagtta aacctcaggt caaccagatt      540

gagttctctc cgttcctgca aaaccaaaca ccaggcattt ataaattctg tcaggagcac      600

gatatcctgg tggaagcata ttctccgctg ggcccgctgc agaagaaaac cgcgcaggat      660

gacagccaac cattttttga gtacgtcaaa gaattgagcg aaaaatacat caaatccgag      720

gcccagatca tcctgcgctg ggtcactaaa cgcggtgtgc tgccagttac cacctcttca      780

aagcctcagc gcattagcga tgctcagaac ctgttttcct tcgacctgac agcggaagag      840

gttgataaaa tcacggagct gggtctggaa catgaaccgc tgcgcctgta ctggaataaa      900

ttgtatggca aatataacta cgccgcccag aaagtgtaa                             939


<210>  138
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YDL ADH from Saccharomyces cervisiae

<400>  138

Met Ser Phe His Gln Gln Phe Phe Thr Leu Asn Asn Gly Asn Lys Ile 
1               5                   10                  15      


Pro Ala Ile Ala Ile Ile Gly Thr Gly Thr Arg Trp Tyr Lys Asn Glu 
            20                  25                  30          


Glu Thr Asp Ala Thr Phe Ser Asn Ser Leu Val Glu Gln Ile Val Tyr 
        35                  40                  45              


Ala Leu Lys Leu Pro Gly Ile Ile His Ile Asp Ala Ala Glu Ile Tyr 
    50                  55                  60                  


Arg Thr Tyr Pro Glu Val Gly Lys Ala Leu Ser Leu Thr Glu Lys Pro 
65                  70                  75                  80  


Arg Asn Ala Ile Phe Leu Thr Asp Lys Tyr Ser Pro Gln Ile Lys Met 
                85                  90                  95      


Ser Asp Ser Pro Ala Asp Gly Leu Asp Leu Ala Leu Lys Lys Met Gly 
            100                 105                 110         


Thr Asp Tyr Val Asp Leu Tyr Leu Leu His Ser Pro Phe Val Ser Lys 
        115                 120                 125             


Glu Val Asn Gly Leu Ser Leu Glu Glu Ala Trp Lys Asp Met Glu Gln 
    130                 135                 140                 


Leu Tyr Lys Ser Gly Lys Ala Lys Asn Ile Gly Val Ser Asn Phe Ala 
145                 150                 155                 160 


Val Glu Asp Leu Gln Arg Ile Leu Lys Val Ala Glu Val Lys Pro Gln 
                165                 170                 175     


Val Asn Gln Ile Glu Phe Ser Pro Phe Leu Gln Asn Gln Thr Pro Gly 
            180                 185                 190         


Ile Tyr Lys Phe Cys Gln Glu His Asp Ile Leu Val Glu Ala Tyr Ser 
        195                 200                 205             


Pro Leu Gly Pro Leu Gln Lys Lys Thr Ala Gln Asp Asp Ser Gln Pro 
    210                 215                 220                 


Phe Phe Glu Tyr Val Lys Glu Leu Ser Glu Lys Tyr Ile Lys Ser Glu 
225                 230                 235                 240 


Ala Gln Ile Ile Leu Arg Trp Val Thr Lys Arg Gly Val Leu Pro Val 
                245                 250                 255     


Thr Thr Ser Ser Lys Pro Gln Arg Ile Ser Asp Ala Gln Asn Leu Phe 
            260                 265                 270         


Ser Phe Asp Leu Thr Ala Glu Glu Val Asp Lys Ile Thr Glu Leu Gly 
        275                 280                 285             


Leu Glu His Glu Pro Leu Arg Leu Tyr Trp Asn Lys Leu Tyr Gly Lys 
    290                 295                 300                 


Tyr Asn Tyr Ala Ala Gln Lys Val 
305                 310         


<210>  139
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YPR ADH from Saccharomyces cervisiae

<400>  139
atgccggcaa cgttaaaaaa cagcagtgct accttaaaat taaacacagg tgcgagcatt       60

cctgtcctgg ggttcggcac ctggcgctct gtcgataaca acggctatca tagtgtaatt      120

gcggcgctga aagcggggta ccgtcatatc gatgctgcgg ccatctatct gaatgaagaa      180

gaagtcggcc gtgcgatcaa ggactccggt gttcctcgtg aagaaatttt tattaccacc      240

aaactgtggg gcaccgaaca acgcgatcca gaagcagccc tgaacaaatc tctgaaacgt      300

ctgggtctgg actatgtgga cctgtatctg atgcactggc cggtccctct gaaaacagac      360

cgtgtaactg acggtaacgt cctgtgcatc ccgaccctgg aagatggcac cgtggacatc      420

gataccaaag agtggaattt tattaaaacc tgggaactga tgcaggaatt gccgaaaact      480

ggtaagacca aagccgtcgg tgtgtccaat ttttccatca acaatatcaa agaactgctg      540

gaatcgccaa ataacaaggt cgttccagca accaatcaga tcgagattca tccgttgctg      600

ccgcaggatg aattaatcgc cttttgtaaa gaaaaaggca ttgtggtcga agcatatagc      660

ccattcggct ccgctaacgc cccgctgctg aaagaacagg cgattatcga tatggccaaa      720

aagcacggcg tcgaaccggc gcaactgatt atcagctggt cgattcagcg cggttatgtg      780

gtattggcca agtccgtaaa tccggagcgt atcgtgtcga actttaagat ttttaccctg      840

ccagaggatg atttcaaaac catctctaac ctgagcaaag tgcacggtac caaacgtgtc      900

gttgacatga aatggggctc atttccgatt tttcaataa                             939


<210>  140
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YPR ADH from Saccharomyces cervisiae

<400>  140

Met Pro Ala Thr Leu Lys Asn Ser Ser Ala Thr Leu Lys Leu Asn Thr 
1               5                   10                  15      


Gly Ala Ser Ile Pro Val Leu Gly Phe Gly Thr Trp Arg Ser Val Asp 
            20                  25                  30          


Asn Asn Gly Tyr His Ser Val Ile Ala Ala Leu Lys Ala Gly Tyr Arg 
        35                  40                  45              


His Ile Asp Ala Ala Ala Ile Tyr Leu Asn Glu Glu Glu Val Gly Arg 
    50                  55                  60                  


Ala Ile Lys Asp Ser Gly Val Pro Arg Glu Glu Ile Phe Ile Thr Thr 
65                  70                  75                  80  


Lys Leu Trp Gly Thr Glu Gln Arg Asp Pro Glu Ala Ala Leu Asn Lys 
                85                  90                  95      


Ser Leu Lys Arg Leu Gly Leu Asp Tyr Val Asp Leu Tyr Leu Met His 
            100                 105                 110         


Trp Pro Val Pro Leu Lys Thr Asp Arg Val Thr Asp Gly Asn Val Leu 
        115                 120                 125             


Cys Ile Pro Thr Leu Glu Asp Gly Thr Val Asp Ile Asp Thr Lys Glu 
    130                 135                 140                 


Trp Asn Phe Ile Lys Thr Trp Glu Leu Met Gln Glu Leu Pro Lys Thr 
145                 150                 155                 160 


Gly Lys Thr Lys Ala Val Gly Val Ser Asn Phe Ser Ile Asn Asn Ile 
                165                 170                 175     


Lys Glu Leu Leu Glu Ser Pro Asn Asn Lys Val Val Pro Ala Thr Asn 
            180                 185                 190         


Gln Ile Glu Ile His Pro Leu Leu Pro Gln Asp Glu Leu Ile Ala Phe 
        195                 200                 205             


Cys Lys Glu Lys Gly Ile Val Val Glu Ala Tyr Ser Pro Phe Gly Ser 
    210                 215                 220                 


Ala Asn Ala Pro Leu Leu Lys Glu Gln Ala Ile Ile Asp Met Ala Lys 
225                 230                 235                 240 


Lys His Gly Val Glu Pro Ala Gln Leu Ile Ile Ser Trp Ser Ile Gln 
                245                 250                 255     


Arg Gly Tyr Val Val Leu Ala Lys Ser Val Asn Pro Glu Arg Ile Val 
            260                 265                 270         


Ser Asn Phe Lys Ile Phe Thr Leu Pro Glu Asp Asp Phe Lys Thr Ile 
        275                 280                 285             


Ser Asn Leu Ser Lys Val His Gly Thr Lys Arg Val Val Asp Met Lys 
    290                 295                 300                 


Trp Gly Ser Phe Pro Ile Phe Gln 
305                 310         


<210>  141
<211>  1029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRE ADH from Saccharomyces cervisiae

<400>  141
atgtctgtgt tcgtgtcagg cgcgaatggt tttattgctc agcacatcgt agatctgctg       60

ctgaaagaag attacaaagt aattggttcc gcacgttctc aggaaaaagc tgaaaatttg      120

accgaagcct tcggtaacaa cccgaaattt agcatggaag tggtgcctga tattagcaaa      180

ctggatgcct tcgatcatgt attccagaaa catggtaaag atattaaaat cgtcctgcat      240

accgcgtccc cgttttgttt cgatattacc gattccgaac gtgacttact gatcccggcg      300

gtaaacggtg tcaaaggtat tttgcacagt attaagaaat atgccgcaga cagcgtggaa      360

cgcgtggttc tgacttcatc ttacgccgcg gtatttgata tggcgaagga aaacgataag      420

agcctgacct tcaacgaaga atcctggaat ccggcgacct gggaatcgtg tcagagtgat      480

ccggtgaacg cttattgcgg ttctaaaaaa ttcgcagaga aagcagcgtg ggaattcttg      540

gaagaaaacc gtgatagcgt gaaatttgag ctgacagcgg tcaacccagt ttacgttttt      600

ggtccgcaga tgttcgataa agatgttaaa aaacacttga acaccagctg cgaactggtg      660

aactctctga tgcatctgag ccctgaagat aaaattccgg aactgtttgg cggttacatc      720

gacgtccgtg acgttgcgaa agctcatctg gttgcatttc agaaacgtga aacaatcggt      780

cagcgcctga tcgtgtcgga ggcacgtttc acgatgcagg acgttctgga cattctgaac      840

gaagactttc cagtactgaa gggcaatatc ccggtcggca agcctggcag cggcgccacc      900

cataatactc tgggcgccac cctggacaat aaaaaaagca aaaaattgct gggcttcaaa      960

ttccgtaatc tgaaagagac tattgacgat actgcgtccc agatcctgaa attcgaaggt     1020

cgcatttaa                                                             1029


<210>  142
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRE ADH from Saccharomyces cervisiae

<400>  142

Met Ser Val Phe Val Ser Gly Ala Asn Gly Phe Ile Ala Gln His Ile 
1               5                   10                  15      


Val Asp Leu Leu Leu Lys Glu Asp Tyr Lys Val Ile Gly Ser Ala Arg 
            20                  25                  30          


Ser Gln Glu Lys Ala Glu Asn Leu Thr Glu Ala Phe Gly Asn Asn Pro 
        35                  40                  45              


Lys Phe Ser Met Glu Val Val Pro Asp Ile Ser Lys Leu Asp Ala Phe 
    50                  55                  60                  


Asp His Val Phe Gln Lys His Gly Lys Asp Ile Lys Ile Val Leu His 
65                  70                  75                  80  


Thr Ala Ser Pro Phe Cys Phe Asp Ile Thr Asp Ser Glu Arg Asp Leu 
                85                  90                  95      


Leu Ile Pro Ala Val Asn Gly Val Lys Gly Ile Leu His Ser Ile Lys 
            100                 105                 110         


Lys Tyr Ala Ala Asp Ser Val Glu Arg Val Val Leu Thr Ser Ser Tyr 
        115                 120                 125             


Ala Ala Val Phe Asp Met Ala Lys Glu Asn Asp Lys Ser Leu Thr Phe 
    130                 135                 140                 


Asn Glu Glu Ser Trp Asn Pro Ala Thr Trp Glu Ser Cys Gln Ser Asp 
145                 150                 155                 160 


Pro Val Asn Ala Tyr Cys Gly Ser Lys Lys Phe Ala Glu Lys Ala Ala 
                165                 170                 175     


Trp Glu Phe Leu Glu Glu Asn Arg Asp Ser Val Lys Phe Glu Leu Thr 
            180                 185                 190         


Ala Val Asn Pro Val Tyr Val Phe Gly Pro Gln Met Phe Asp Lys Asp 
        195                 200                 205             


Val Lys Lys His Leu Asn Thr Ser Cys Glu Leu Val Asn Ser Leu Met 
    210                 215                 220                 


His Leu Ser Pro Glu Asp Lys Ile Pro Glu Leu Phe Gly Gly Tyr Ile 
225                 230                 235                 240 


Asp Val Arg Asp Val Ala Lys Ala His Leu Val Ala Phe Gln Lys Arg 
                245                 250                 255     


Glu Thr Ile Gly Gln Arg Leu Ile Val Ser Glu Ala Arg Phe Thr Met 
            260                 265                 270         


Gln Asp Val Leu Asp Ile Leu Asn Glu Asp Phe Pro Val Leu Lys Gly 
        275                 280                 285             


Asn Ile Pro Val Gly Lys Pro Gly Ser Gly Ala Thr His Asn Thr Leu 
    290                 295                 300                 


Gly Ala Thr Leu Asp Asn Lys Lys Ser Lys Lys Leu Leu Gly Phe Lys 
305                 310                 315                 320 


Phe Arg Asn Leu Lys Glu Thr Ile Asp Asp Thr Ala Ser Gln Ile Leu 
                325                 330                 335     


Lys Phe Glu Gly Arg Ile 
            340         


<210>  143
<211>  1041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Streptomycel coelicolor

<400>  143
atgaaggcac tgcagtaccg caccatcggc gccccgcccg aggtcgtcac cgtcccggac       60

ccggagccgg gccccggcca ggtgctgttg aaggtgaccg cggccggagt ctgccactcc      120

gacatcgcgg tgatgagctg gcccgccgag ggcttcccgt acgagctgcc gctcaccctc      180

ggccacgagg gcgtcggcac cgtggccgcg ctcggcgccg gggtgacggg gctcgccgag      240

ggcgacgcgg tcgccgtgta cgggccctgg ggctgcggca cctgcgccaa gtgcgcggag      300

ggcaaggaga actactgcct gcgcgccgac gagctgggca tccgtccgcc ggggctcggg      360

cgtccggggt ccatggccga gtacctgctg atcgacgacc cccggcacct ggtcccgctg      420

gacgggctcg acccggtcgc ggcggtgccg ctcaccgacg ccggactgac gccgtaccac      480

gcgatcaagc ggtcgctgcc caagctggtc cccggctcca ccgcggtggt catcggcacc      540

ggtggtctcg gccacgtcgc catccagctg ctgcgcgccc tgacgtccgc ccgggtggtc      600

gccctggacg tcagcgagga gaagctgcgc ctcgcccgtg cggtgggcgc gcacgaggcg      660

gtgctgtcgg acgcgaaggc cgcggacgcg gtgcgcgaga tcaccggcgg tctcggtgcc      720

gaggccgtgt tcgacttcgt cggcgtggcg cccaccgtgc agaccgccgg agccgtcgcg      780

gccgtcgagg gcgatgtcac cctggtcggc atcggcggcg gatcgctgcc cgtcggcttc      840

ggcatgctgc cgttcgaggt gtcggtcaac gccccctact ggggcagccg cagcgagctg      900

accgaggtgc tgaacctggc ccgctccggt gccgtgtcgg tgcacaccga gacgtactcc      960

ctggacgacg ccccgctcgc ctacgagcgg ctgcacgagg gcagggtcaa cggccgcgcg     1020

gtgatcctgc cccacggctg a                                               1041


<210>  144
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Streptomycel coelicolor

<400>  144

Met Lys Ala Leu Gln Tyr Arg Thr Ile Gly Ala Pro Pro Glu Val Val 
1               5                   10                  15      


Thr Val Pro Asp Pro Glu Pro Gly Pro Gly Gln Val Leu Leu Lys Val 
            20                  25                  30          


Thr Ala Ala Gly Val Cys His Ser Asp Ile Ala Val Met Ser Trp Pro 
        35                  40                  45              


Ala Glu Gly Phe Pro Tyr Glu Leu Pro Leu Thr Leu Gly His Glu Gly 
    50                  55                  60                  


Val Gly Thr Val Ala Ala Leu Gly Ala Gly Val Thr Gly Leu Ala Glu 
65                  70                  75                  80  


Gly Asp Ala Val Ala Val Tyr Gly Pro Trp Gly Cys Gly Thr Cys Ala 
                85                  90                  95      


Lys Cys Ala Glu Gly Lys Glu Asn Tyr Cys Leu Arg Ala Asp Glu Leu 
            100                 105                 110         


Gly Ile Arg Pro Pro Gly Leu Gly Arg Pro Gly Ser Met Ala Glu Tyr 
        115                 120                 125             


Leu Leu Ile Asp Asp Pro Arg His Leu Val Pro Leu Asp Gly Leu Asp 
    130                 135                 140                 


Pro Val Ala Ala Val Pro Leu Thr Asp Ala Gly Leu Thr Pro Tyr His 
145                 150                 155                 160 


Ala Ile Lys Arg Ser Leu Pro Lys Leu Val Pro Gly Ser Thr Ala Val 
                165                 170                 175     


Val Ile Gly Thr Gly Gly Leu Gly His Val Ala Ile Gln Leu Leu Arg 
            180                 185                 190         


Ala Leu Thr Ser Ala Arg Val Val Ala Leu Asp Val Ser Glu Glu Lys 
        195                 200                 205             


Leu Arg Leu Ala Arg Ala Val Gly Ala His Glu Ala Val Leu Ser Asp 
    210                 215                 220                 


Ala Lys Ala Ala Asp Ala Val Arg Glu Ile Thr Gly Gly Leu Gly Ala 
225                 230                 235                 240 


Glu Ala Val Phe Asp Phe Val Gly Val Ala Pro Thr Val Gln Thr Ala 
                245                 250                 255     


Gly Ala Val Ala Ala Val Glu Gly Asp Val Thr Leu Val Gly Ile Gly 
            260                 265                 270         


Gly Gly Ser Leu Pro Val Gly Phe Gly Met Leu Pro Phe Glu Val Ser 
        275                 280                 285             


Val Asn Ala Pro Tyr Trp Gly Ser Arg Ser Glu Leu Thr Glu Val Leu 
    290                 295                 300                 


Asn Leu Ala Arg Ser Gly Ala Val Ser Val His Thr Glu Thr Tyr Ser 
305                 310                 315                 320 


Leu Asp Asp Ala Pro Leu Ala Tyr Glu Arg Leu His Glu Gly Arg Val 
                325                 330                 335     


Asn Gly Arg Ala Val Ile Leu Pro His Gly 
            340                 345     


<210>  145
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Sporobolomyces salmonicolor

<400>  145
atggcaaaga tcgacaacgc agttctgccg gagggttctc tggtgctggt caccggcgcg       60

aacggctttg tcgctagcca tgtggtcgaa caactgctgg aacacggcta taaggtgcgc      120

ggcactgctc gctctgcctc caaactggcg aacctgcaga aacgttggga cgccaaatac      180

cctggtcgtt tcgagactgc cgttgttgaa gacatgctga agcagggtgc atatgatgaa      240

gttattaaag gcgcggcagg tgtcgcccac atcgcgtccg tggtcagctt ttctaacaaa      300

tatgatgagg tggtaactcc tgcgatcggt ggcacgctga atgccctgcg tgccgcagct      360

gctacgcctt ccgtgaaacg ttttgtgctg accagcagca ctgtttctgc actgattcca      420

aaacctaacg tcgaaggtat ttatctggat gagaagagct ggaacctgga aagcattgat      480

aaggctaaaa ccctgcctga atctgatccg cagaaaagcc tgtgggtcta cgccgcaagc      540

aaaacggaag cggaactggc tgcctggaaa ttcatggacg aaaacaaacc gcactttact      600

ctgaatgccg ttctgccaaa ctacactatc ggtaccattt ttgacccaga aacccaatcc      660

ggttccactt ccggctggat gatgtctctg ttcaatggcg aagtatctcc ggcactggcg      720

ctgatgccgc cgcagtacta tgtctctgca gttgatatcg gtctgctgca cctgggttgt      780

ctggttctgc cgcaaatcga acgccgtcgt gtttacggca ccgcaggcac ctttgattgg      840

aacaccgttc tggcgacctt ccgtaaactg tatccgtcca agacgttccc ggctgacttt      900

ccggatcagg gccaggatct gtccaaattt gataccgccc cgagcctgga gattctgaaa      960

tccctgggcc gccctggctg gcgtagcatc gaggaatcta tcaaagatct ggtgggttcc     1020

gagaccgcct aa                                                         1032


<210>  146
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Sporobolomyces salmonicolor

<400>  146

Met Ala Lys Ile Asp Asn Ala Val Leu Pro Glu Gly Ser Leu Val Leu 
1               5                   10                  15      


Val Thr Gly Ala Asn Gly Phe Val Ala Ser His Val Val Glu Gln Leu 
            20                  25                  30          


Leu Glu His Gly Tyr Lys Val Arg Gly Thr Ala Arg Ser Ala Ser Lys 
        35                  40                  45              


Leu Ala Asn Leu Gln Lys Arg Trp Asp Ala Lys Tyr Pro Gly Arg Phe 
    50                  55                  60                  


Glu Thr Ala Val Val Glu Asp Met Leu Lys Gln Gly Ala Tyr Asp Glu 
65                  70                  75                  80  


Val Ile Lys Gly Ala Ala Gly Val Ala His Ile Ala Ser Val Val Ser 
                85                  90                  95      


Phe Ser Asn Lys Tyr Asp Glu Val Val Thr Pro Ala Ile Gly Gly Thr 
            100                 105                 110         


Leu Asn Ala Leu Arg Ala Ala Ala Ala Thr Pro Ser Val Lys Arg Phe 
        115                 120                 125             


Val Leu Thr Ser Ser Thr Val Ser Ala Leu Ile Pro Lys Pro Asn Val 
    130                 135                 140                 


Glu Gly Ile Tyr Leu Asp Glu Lys Ser Trp Asn Leu Glu Ser Ile Asp 
145                 150                 155                 160 


Lys Ala Lys Thr Leu Pro Glu Ser Asp Pro Gln Lys Ser Leu Trp Val 
                165                 170                 175     


Tyr Ala Ala Ser Lys Thr Glu Ala Glu Leu Ala Ala Trp Lys Phe Met 
            180                 185                 190         


Asp Glu Asn Lys Pro His Phe Thr Leu Asn Ala Val Leu Pro Asn Tyr 
        195                 200                 205             


Thr Ile Gly Thr Ile Phe Asp Pro Glu Thr Gln Ser Gly Ser Thr Ser 
    210                 215                 220                 


Gly Trp Met Met Ser Leu Phe Asn Gly Glu Val Ser Pro Ala Leu Ala 
225                 230                 235                 240 


Leu Met Pro Pro Gln Tyr Tyr Val Ser Ala Val Asp Ile Gly Leu Leu 
                245                 250                 255     


His Leu Gly Cys Leu Val Leu Pro Gln Ile Glu Arg Arg Arg Val Tyr 
            260                 265                 270         


Gly Thr Ala Gly Thr Phe Asp Trp Asn Thr Val Leu Ala Thr Phe Arg 
        275                 280                 285             


Lys Leu Tyr Pro Ser Lys Thr Phe Pro Ala Asp Phe Pro Asp Gln Gly 
    290                 295                 300                 


Gln Asp Leu Ser Lys Phe Asp Thr Ala Pro Ser Leu Glu Ile Leu Lys 
305                 310                 315                 320 


Ser Leu Gly Arg Pro Gly Trp Arg Ser Ile Glu Glu Ser Ile Lys Asp 
                325                 330                 335     


Leu Val Gly Ser Glu Thr Ala 
            340             


<210>  147
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Aspergillus flavus

<400>  147
atgtctattc cggaaatgca atgggctcaa gtagcggagc agaaaggcgg tccgctgatt       60

tacaaacaga ttccggttcc gaaaccgggc ccggacgaaa tcctggtaaa agtgcgttac      120

tctggtgtgt gccacacgga tctgcacgcg ctgaaaggtg actggccact gcctgtgaaa      180

atgccactgg tgggtggcca tgagggcgcg ggtgttgtcg tcgctcgtgg cgatctggtt      240

actgagttcg aaattggtga ccatgctggc ctgaaatggc tgaacggtag ctgcctggca      300

tgcgagttct gtaaacaggc tgacgaaccg ctgtgcccta acgcgagcct gtctggttat      360

actgtagatg gtactttcca gcagtatgcc attggcaaag ccacccatgc gagcaagctg      420

ccgaaaaacg tgcctctgga tgccgtggca ccggttctgt gcgcgggcat taccgtatac      480

aagggcctga aagaaagcgg tgttcgtcct ggccaaaccg ttgcgatcgt aggtgcgggt      540

ggtggtctgg gctccctggc gctgcagtac gcgaaagcta tgggtattcg cgtggtggcg      600

attgatggcg gtgaagagaa acaagcgatg tgtgaacagc tgggcgcaga agcctacgtt      660

gactttacca aaacgcaaga tctggtagca gatgttaagg ccgccacccc tgaaggtctg      720

ggcgcgcatg cggtaattct gctggcggtc gccgaaaaac catttcagca ggcggccgaa      780

tatgtcagcc gtggtacggt ggttgccatt ggtctgccgg cgggcgcatt cctgcgcgcg      840

ccggtgttta acactgtggt tcgtatgatt aacattaagg gtagctacgt tggcaaccgc      900

caggacggcg ttgaggcagt ggacttcttc gcgcgcggcc tgatcaaagc gccgttcaaa      960

accgctcctc tgcaagatct gccgaaaatc ttcgaactga tggaacaagg taagattgca     1020

ggtcgctacg ttctggaaat cccggaatga                                      1050


<210>  148
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Aspergillus flavus

<400>  148

Met Ser Ile Pro Glu Met Gln Trp Ala Gln Val Ala Glu Gln Lys Gly 
1               5                   10                  15      


Gly Pro Leu Ile Tyr Lys Gln Ile Pro Val Pro Lys Pro Gly Pro Asp 
            20                  25                  30          


Glu Ile Leu Val Lys Val Arg Tyr Ser Gly Val Cys His Thr Asp Leu 
        35                  40                  45              


His Ala Leu Lys Gly Asp Trp Pro Leu Pro Val Lys Met Pro Leu Val 
    50                  55                  60                  


Gly Gly His Glu Gly Ala Gly Val Val Val Ala Arg Gly Asp Leu Val 
65                  70                  75                  80  


Thr Glu Phe Glu Ile Gly Asp His Ala Gly Leu Lys Trp Leu Asn Gly 
                85                  90                  95      


Ser Cys Leu Ala Cys Glu Phe Cys Lys Gln Ala Asp Glu Pro Leu Cys 
            100                 105                 110         


Pro Asn Ala Ser Leu Ser Gly Tyr Thr Val Asp Gly Thr Phe Gln Gln 
        115                 120                 125             


Tyr Ala Ile Gly Lys Ala Thr His Ala Ser Lys Leu Pro Lys Asn Val 
    130                 135                 140                 


Pro Leu Asp Ala Val Ala Pro Val Leu Cys Ala Gly Ile Thr Val Tyr 
145                 150                 155                 160 


Lys Gly Leu Lys Glu Ser Gly Val Arg Pro Gly Gln Thr Val Ala Ile 
                165                 170                 175     


Val Gly Ala Gly Gly Gly Leu Gly Ser Leu Ala Leu Gln Tyr Ala Lys 
            180                 185                 190         


Ala Met Gly Ile Arg Val Val Ala Ile Asp Gly Gly Glu Glu Lys Gln 
        195                 200                 205             


Ala Met Cys Glu Gln Leu Gly Ala Glu Ala Tyr Val Asp Phe Thr Lys 
    210                 215                 220                 


Thr Gln Asp Leu Val Ala Asp Val Lys Ala Ala Thr Pro Glu Gly Leu 
225                 230                 235                 240 


Gly Ala His Ala Val Ile Leu Leu Ala Val Ala Glu Lys Pro Phe Gln 
                245                 250                 255     


Gln Ala Ala Glu Tyr Val Ser Arg Gly Thr Val Val Ala Ile Gly Leu 
            260                 265                 270         


Pro Ala Gly Ala Phe Leu Arg Ala Pro Val Phe Asn Thr Val Val Arg 
        275                 280                 285             


Met Ile Asn Ile Lys Gly Ser Tyr Val Gly Asn Arg Gln Asp Gly Val 
    290                 295                 300                 


Glu Ala Val Asp Phe Phe Ala Arg Gly Leu Ile Lys Ala Pro Phe Lys 
305                 310                 315                 320 


Thr Ala Pro Leu Gln Asp Leu Pro Lys Ile Phe Glu Leu Met Glu Gln 
                325                 330                 335     


Gly Lys Ile Ala Gly Arg Tyr Val Leu Glu Ile Pro Glu 
            340                 345                 


<210>  149
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Oenococcus oeni

<400>  149
atgtttgatc gcctgaaggg taaggtggcg atcgtcaccg gcggtaatag cggtattggt       60

aaggcaatcg cggcagactt catcgccgag ggcgcgaaag tagtgattac cggtcgcaac      120

caagagaagg gtcgccagac tgcgctggaa atcgccggtg acattctgtt cattcagcag      180

gacgtgagcc aggaggcgga ctggcagaaa gttatctcca aaaccatcga gaagttcggt      240

aagtttgata ttctggttaa caacgctggc gtcggcggcg tgggtaagcc actggcagaa      300

atgtccctgt ctgaattcaa ttggacccaa tccattaatc tgtccggtaa cttcctgggt      360

attcacttcg cgctgaacaa aatgaccgaa cctggtagca ttattgacgt aagcagcgcg      420

gctggcctgc gtggttttcc gggcgcagcc gattatagcg cttccaaagg tggtacgcgt      480

ctgctgacgc gcgccgcggc gctggaagcg ctgcaaatgg gtaaaaagat ccgtgtaaac      540

tctattcacc caggttggat tgataccgat atcgtaccaa aagatatgcg tgagcaggtt      600

atcgcgatga cccctatgca tcacctgggc caaccgaaag atattgccaa gctggcgacg      660

tatctggcat ctgacgagtc cgagtatact acgggctccg aactggcagc cgacggcggt      720

ctgatggca                                                              729


<210>  150
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Oenococcus oeni

<400>  150

Met Phe Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Asn 
1               5                   10                  15      


Ser Gly Ile Gly Lys Ala Ile Ala Ala Asp Phe Ile Ala Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Asn Gln Glu Lys Gly Arg Gln Thr Ala 
        35                  40                  45              


Leu Glu Ile Ala Gly Asp Ile Leu Phe Ile Gln Gln Asp Val Ser Gln 
    50                  55                  60                  


Glu Ala Asp Trp Gln Lys Val Ile Ser Lys Thr Ile Glu Lys Phe Gly 
65                  70                  75                  80  


Lys Phe Asp Ile Leu Val Asn Asn Ala Gly Val Gly Gly Val Gly Lys 
                85                  90                  95      


Pro Leu Ala Glu Met Ser Leu Ser Glu Phe Asn Trp Thr Gln Ser Ile 
            100                 105                 110         


Asn Leu Ser Gly Asn Phe Leu Gly Ile His Phe Ala Leu Asn Lys Met 
        115                 120                 125             


Thr Glu Pro Gly Ser Ile Ile Asp Val Ser Ser Ala Ala Gly Leu Arg 
    130                 135                 140                 


Gly Phe Pro Gly Ala Ala Asp Tyr Ser Ala Ser Lys Gly Gly Thr Arg 
145                 150                 155                 160 


Leu Leu Thr Arg Ala Ala Ala Leu Glu Ala Leu Gln Met Gly Lys Lys 
                165                 170                 175     


Ile Arg Val Asn Ser Ile His Pro Gly Trp Ile Asp Thr Asp Ile Val 
            180                 185                 190         


Pro Lys Asp Met Arg Glu Gln Val Ile Ala Met Thr Pro Met His His 
        195                 200                 205             


Leu Gly Gln Pro Lys Asp Ile Ala Lys Leu Ala Thr Tyr Leu Ala Ser 
    210                 215                 220                 


Asp Glu Ser Glu Tyr Thr Thr Gly Ser Glu Leu Ala Ala Asp Gly Gly 
225                 230                 235                 240 


Leu Met Ala 
            


<210>  151
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Ralstonia eutropha

<400>  151
atgcagggca aaattgcact ggttacgggc ggtgcgtctg gtatgggtct ggccttcacc       60

cgtcgcctgg cccaagaagg cgcacgtgtt tacttcaccg acattaacgg cgccgcgggt      120

cacgcgacgg aaagcgagct gcagggtgct ggtctggcgg tcgtattcct gcgtcatgac      180

gtgacccagg aaaacgactg gctgcgcgtc ctggaacata ttggcgctgt tgacggtcgc      240

ctggatgtac tggtgaataa tgccggcatt gcgatttctc acaacattga gacttgtact      300

actgaggatt ttgatcgcac gctgaatgtt aacctgaagt ccgtgtttct gggctgcaaa      360

cacggtctgg ctctgatgaa acagaagggt ggcagcatca ttaacgttag ctctatcacc      420

gcgatttgcg gcgaacctgt ggcgctggcg tatagcgcta gcaaagccgg cgtccgtttt      480

ctgagcaagt ctgttgccct gcattgtgcg gagaagggct acgccatccg tgttaacagc      540

ctgcacccgg gttacattga taccccgctg ctggcaggca gcaacgcggg tggctccctg      600

accgctgacg aggtaaccgc gagccgtgta cgtattggcg gtgaaattcc gctgaaacgt      660

cgcggcaccc cggacgaagt tgcaggcgcg gttctgtacc tggctagcga tgaatccacc      720

tatgttactg gtactgagct ggtaattgat ggcggctacg catgtcat                   768


<210>  152
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Ralstonia eutropha

<400>  152

Met Gln Gly Lys Ile Ala Leu Val Thr Gly Gly Ala Ser Gly Met Gly 
1               5                   10                  15      


Leu Ala Phe Thr Arg Arg Leu Ala Gln Glu Gly Ala Arg Val Tyr Phe 
            20                  25                  30          


Thr Asp Ile Asn Gly Ala Ala Gly His Ala Thr Glu Ser Glu Leu Gln 
        35                  40                  45              


Gly Ala Gly Leu Ala Val Val Phe Leu Arg His Asp Val Thr Gln Glu 
    50                  55                  60                  


Asn Asp Trp Leu Arg Val Leu Glu His Ile Gly Ala Val Asp Gly Arg 
65                  70                  75                  80  


Leu Asp Val Leu Val Asn Asn Ala Gly Ile Ala Ile Ser His Asn Ile 
                85                  90                  95      


Glu Thr Cys Thr Thr Glu Asp Phe Asp Arg Thr Leu Asn Val Asn Leu 
            100                 105                 110         


Lys Ser Val Phe Leu Gly Cys Lys His Gly Leu Ala Leu Met Lys Gln 
        115                 120                 125             


Lys Gly Gly Ser Ile Ile Asn Val Ser Ser Ile Thr Ala Ile Cys Gly 
    130                 135                 140                 


Glu Pro Val Ala Leu Ala Tyr Ser Ala Ser Lys Ala Gly Val Arg Phe 
145                 150                 155                 160 


Leu Ser Lys Ser Val Ala Leu His Cys Ala Glu Lys Gly Tyr Ala Ile 
                165                 170                 175     


Arg Val Asn Ser Leu His Pro Gly Tyr Ile Asp Thr Pro Leu Leu Ala 
            180                 185                 190         


Gly Ser Asn Ala Gly Gly Ser Leu Thr Ala Asp Glu Val Thr Ala Ser 
        195                 200                 205             


Arg Val Arg Ile Gly Gly Glu Ile Pro Leu Lys Arg Arg Gly Thr Pro 
    210                 215                 220                 


Asp Glu Val Ala Gly Ala Val Leu Tyr Leu Ala Ser Asp Glu Ser Thr 
225                 230                 235                 240 


Tyr Val Thr Gly Thr Glu Leu Val Ile Asp Gly Gly Tyr Ala Cys His 
                245                 250                 255     


<210>  153
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Thermoanaerobium brockii

<400>  153
atgaaaggct tcgccatgct gagcatcggc aaagtgggtt ggattgaaaa agaaaaaccg       60

gcgccaggcc cgttcgatgc aattgtgcgc cctctggcag tagcgccgtg taccagcgat      120

attcatactg tgtttgaagg tgccattggc gagcgtcaca atatgattct gggccatgaa      180

gccgttggtg aagttgttga ggttggcagc gaagtgaagg atttcaaacc gggcgatcgc      240

gttgtcgttc cagcgattac cccggattgg cgcaccagcg aagtccagcg cggctaccat      300

cagcactctg gcggcatgct ggccggctgg aaattcagca atgtaaagga tggtgtgttc      360

ggtgaatttt ttcacgttaa cgacgcagac atgaatctgg cgcacctgcc gaaagaaatc      420

ccgctggaag cagcggttat gattccggat atgatgacca cgggttttca cggcgcagag      480

ctggcggaca ttgaactggg cgctacggta gccgtactgg gcatcggtcc ggtgggcctg      540

atggcagttg caggcgctaa gctgcgcggc gcaggtcgta ttattgccgt tggttctcgc      600

ccggtgtgtg tggacgccgc taagtattat ggtgcaacgg acattgtcaa ttacaaggac      660

ggcccaattg aatctcagat catgaacctg acggaaggta aaggcgttga cgccgcgatt      720

atcgctggcg gcaacgccga catcatggcg accgcagtta aaatcgtcaa gccaggtggt      780

actattgcta acgtcaacta cttcggcgaa ggtgaggtcc tgcctgtccc acgtctggaa      840

tggggttgcg gtatggcaca taaaaccatt aaaggtggcc tgtgcccagg cggccgtctg      900

cgtatggaac gcctgatcga tctggtcttc tacaaacgcg tggatcctag caaactggtg      960

actcacgttt tccgcggctt tgataacatc gaaaaagctt ttatgctgat gaaagataaa     1020

ccgaaagatc tgattaaacc ggttgtcatc ctggct                               1056


<210>  154
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Thermoanaerobium brockii

<400>  154

Met Lys Gly Phe Ala Met Leu Ser Ile Gly Lys Val Gly Trp Ile Glu 
1               5                   10                  15      


Lys Glu Lys Pro Ala Pro Gly Pro Phe Asp Ala Ile Val Arg Pro Leu 
            20                  25                  30          


Ala Val Ala Pro Cys Thr Ser Asp Ile His Thr Val Phe Glu Gly Ala 
        35                  40                  45              


Ile Gly Glu Arg His Asn Met Ile Leu Gly His Glu Ala Val Gly Glu 
    50                  55                  60                  


Val Val Glu Val Gly Ser Glu Val Lys Asp Phe Lys Pro Gly Asp Arg 
65                  70                  75                  80  


Val Val Val Pro Ala Ile Thr Pro Asp Trp Arg Thr Ser Glu Val Gln 
                85                  90                  95      


Arg Gly Tyr His Gln His Ser Gly Gly Met Leu Ala Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Val Lys Asp Gly Val Phe Gly Glu Phe Phe His Val Asn Asp 
        115                 120                 125             


Ala Asp Met Asn Leu Ala His Leu Pro Lys Glu Ile Pro Leu Glu Ala 
    130                 135                 140                 


Ala Val Met Ile Pro Asp Met Met Thr Thr Gly Phe His Gly Ala Glu 
145                 150                 155                 160 


Leu Ala Asp Ile Glu Leu Gly Ala Thr Val Ala Val Leu Gly Ile Gly 
                165                 170                 175     


Pro Val Gly Leu Met Ala Val Ala Gly Ala Lys Leu Arg Gly Ala Gly 
            180                 185                 190         


Arg Ile Ile Ala Val Gly Ser Arg Pro Val Cys Val Asp Ala Ala Lys 
        195                 200                 205             


Tyr Tyr Gly Ala Thr Asp Ile Val Asn Tyr Lys Asp Gly Pro Ile Glu 
    210                 215                 220                 


Ser Gln Ile Met Asn Leu Thr Glu Gly Lys Gly Val Asp Ala Ala Ile 
225                 230                 235                 240 


Ile Ala Gly Gly Asn Ala Asp Ile Met Ala Thr Ala Val Lys Ile Val 
                245                 250                 255     


Lys Pro Gly Gly Thr Ile Ala Asn Val Asn Tyr Phe Gly Glu Gly Glu 
            260                 265                 270         


Val Leu Pro Val Pro Arg Leu Glu Trp Gly Cys Gly Met Ala His Lys 
        275                 280                 285             


Thr Ile Lys Gly Gly Leu Cys Pro Gly Gly Arg Leu Arg Met Glu Arg 
    290                 295                 300                 


Leu Ile Asp Leu Val Phe Tyr Lys Arg Val Asp Pro Ser Lys Leu Val 
305                 310                 315                 320 


Thr His Val Phe Arg Gly Phe Asp Asn Ile Glu Lys Ala Phe Met Leu 
                325                 330                 335     


Met Lys Asp Lys Pro Lys Asp Leu Ile Lys Pro Val Val Ile Leu Ala 
            340                 345                 350         


<210>  155
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH from Hore Liver E form

<400>  155
atgagcacag cagggaaagt aattaaatgc aaagcagctg tgctgtggga ggaaaagaaa       60

ccattttcca ttgaggaggt ggaggtcgca cctccgaagg cccatgaagt ccgtattaag      120

atggtggcca cagggatctg tcgctcagat gaccacgtgg ttagtgggac cctggtcaca      180

cctctgcctg tgatcgcagg ccatgaggca gctggcattg tggagagcat cggggaaggc      240

gtcactacag tacgtccagg tgataaagtc atcccactgt ttactcctca gtgtgggaaa      300

tgccgtgttt gtaaacaccc tgaaggcaac ttctgcttga aaaatgatct gagcatgcct      360

cgtgggacca tgcaggatgg taccagccgt ttcacctgcc gtgggaagcc tatccaccac      420

ttcctgggca ccagcacctt ctcccagtac accgtggtgg acgagatctc agtggccaag      480

atcgatgcgg cctcaccgct ggagaaagtc tgtctgattg gctgtgggtt ttctactggt      540

tatgggtctg cagtcaaggt tgccaaggtc acccagggct ccacctgtgc cgtgtttggc      600

ctgggggggg tgggcctgtc tgttatcatg ggctgtaaag cagccggggc ggcccgtatc      660

attggggtgg acatcaacaa agacaagttt gcaaaggcca aagaagtggg tgccactgag      720

tgtgtcaacc ctcaggacta caagaaacct atccaggagg tgctgacaga aatgagcaat      780

gggggcgtgg atttttcatt tgaagtcatt ggtcgtctgg acaccatggt gactgccttg      840

tcatgctgtc aagaagcata tggtgtgagc gtcatcgtag gggtacctcc tgattcccaa      900

aatctgtcta tgaatcctat gttgctgctg agtgggcgta cctggaaagg ggctattttt      960

ggtggtttta agagtaaaga ttctgtccct aaactggtgg ccgattttat ggctaaaaag     1020

tttgcactgg atcctttaat cacccatgtt ttaccttttg aaaaaattaa tgaagggttt     1080

gacctgctgc gctctgggga gagtatccgt accatcctga cgttt                     1125


<210>  156
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH from Hore Liver

<400>  156

Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      


Glu Glu Lys Lys Pro Phe Ser Ile Glu Glu Val Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala His Glu Val Arg Ile Lys Met Val Ala Thr Gly Ile Cys Arg 
        35                  40                  45              


Ser Asp Asp His Val Val Ser Gly Thr Leu Val Thr Pro Leu Pro Val 
    50                  55                  60                  


Ile Ala Gly His Glu Ala Ala Gly Ile Val Glu Ser Ile Gly Glu Gly 
65                  70                  75                  80  


Val Thr Thr Val Arg Pro Gly Asp Lys Val Ile Pro Leu Phe Thr Pro 
                85                  90                  95      


Gln Cys Gly Lys Cys Arg Val Cys Lys His Pro Glu Gly Asn Phe Cys 
            100                 105                 110         


Leu Lys Asn Asp Leu Ser Met Pro Arg Gly Thr Met Gln Asp Gly Thr 
        115                 120                 125             


Ser Arg Phe Thr Cys Arg Gly Lys Pro Ile His His Phe Leu Gly Thr 
    130                 135                 140                 


Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Ile Ser Val Ala Lys 
145                 150                 155                 160 


Ile Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly 
                165                 170                 175     


Phe Ser Thr Gly Tyr Gly Ser Ala Val Lys Val Ala Lys Val Thr Gln 
            180                 185                 190         


Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val 
        195                 200                 205             


Ile Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Gly Val Asp 
    210                 215                 220                 


Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Val Gly Ala Thr Glu 
225                 230                 235                 240 


Cys Val Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Thr 
                245                 250                 255     


Glu Met Ser Asn Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg 
            260                 265                 270         


Leu Asp Thr Met Val Thr Ala Leu Ser Cys Cys Gln Glu Ala Tyr Gly 
        275                 280                 285             


Val Ser Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met 
    290                 295                 300                 


Asn Pro Met Leu Leu Leu Ser Gly Arg Thr Trp Lys Gly Ala Ile Phe 
305                 310                 315                 320 


Gly Gly Phe Lys Ser Lys Asp Ser Val Pro Lys Leu Val Ala Asp Phe 
                325                 330                 335     


Met Ala Lys Lys Phe Ala Leu Asp Pro Leu Ile Thr His Val Leu Pro 
            340                 345                 350         


Phe Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu Arg Ser Gly Glu Ser 
        355                 360                 365             


Ile Arg Thr Ile Leu Thr Phe 
    370                 375 


<210>  157
<211>  759
<212>  DNA
<213>  Lactobacillus Minor

<400>  157
atgaccgatc ggttgaaggg gaaagtagca attgtaactg gcggtacctt gggaattggc       60

ttggcaatcg ctgataagtt tgttgaagaa ggcgcaaagg ttgttattac cggccgtcac      120

gctgatgtag gtgaaaaagc tgccagatca atcggcggca cagacgttat ccgttttgtc      180

caacacgatg cttctgatga aaccggctgg actaagttgt ttgatacgac tgaagaagca      240

tttggcccag ttaccacggt tgtcaacaat gccggaattg cggtcagcaa gagtgttgaa      300

gataccacaa ctgaagaatg gcgcaagctg ctctcagtta acttggatgg tgtcttcttc      360

ggtacccgtc ttggaatcca acgtatgaag aataaaggac tcggagcatc aatcatcaat      420

atgtcatcta tcgaaggttt tgttggtgat ccagctctgg gtgcatacaa cgcttcaaaa      480

ggtgctgtca gaattatgtc taaatcagct gccttggatt gcgctttgaa ggactacgat      540

gttcgggtta acactgttca tccaggttat atcaagacac cattggttga cgatcttgaa      600

ggggcagaag aaatgatgtc acagcggacc aagacaccaa tgggtcatat cggtgaacct      660

aacgatatcg cttggatctg tgtttacctg gcatctgacg aatctaaatt tgccactggt      720

gcagaattcg ttgtcgacgg agggtacacc gcccaatag                             759


<210>  158
<211>  252
<212>  PRT
<213>  Lactobacillus Minor

<400>  158

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Arg Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Thr Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Glu Gly Phe Val Gly Asp Pro Ala Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Tyr Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  159
<211>  759
<212>  DNA
<213>  variant of L. Minor

<400>  159
atgaccgatc ggttgaaggg gaaagtagca attgtaactg gcggtacctt gggaattggc       60

ttggcaatcg ctgataagtt tgttgaagaa ggcgcaaagg ttgttattac cggccgtcac      120

gctgatgtag gtgaaaaagc tgccagatca atcggcggca cagacgttat ccgttttgtc      180

caacacgatg cttctgatga aaccggctgg actaagttgt ttgatacgac tgaagaagca      240

tttggcccag ttaccacggt tgtcaacaat gccggaattg cggtcagcaa gagtgttgaa      300

gataccacaa ctgaagaatg gcgcaagctg ctctcagtta acttggatgg tgtcttcttc      360

ggtacccgtc ttggaatcca acgtatgaag aataaaggac tcggagcatc aatcatcaat      420

atgtcatcta tcagtggttt tgttggtgat ccagctctgg gtgcatacaa cgcttcaaaa      480

ggtgctgtca gaattatgtc taaatcagct gccttggatt gcgctttgaa ggactacgat      540

gttcgggtta acactgttca tccaggttgt atcaagacac cattggttga cgatcttgaa      600

ggggcagaag aaatgatgtc acagcggacc aagacaccaa tgggtcatat cggtgaacct      660

aacgatatcg cttggatctg tgtttacctg gcatctgacg aatctaaatt tgccactggt      720

gcagaattcg ttgtcgacgg agggtacacc gcccaatag                             759


<210>  160
<211>  252
<212>  PRT
<213>  variant of L. Minor

<400>  160

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Arg Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Thr Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Ala Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  161
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Ketoreductase Sequence Formula with L. brevis backbone
       Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is an acidic polar or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is a polar or non-polar residue

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is a non-polar, apliphatic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is a non-polar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is an acidic, nonpolar or polar residue

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is an acidic, aliphatic or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is a constrained, basic, or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa is an acidic or a nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa is a nonpolar or an acidic residue

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa is an acidic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa is a nonpolar or a polar residue

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is an aliphatic, non-polar, or acidic residue

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  Xaa is polar residue

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa is an acidic, non-polar, or a polar residue

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is an acidic or non-polar residue

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa is a hydrophilic, polar or constrained residue

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa is a non-polar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa is an acidic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  Xaa s a nonpolar or polar residue

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  Xaa is a basic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (145)..(145)
<223>  Xaa is a polar residue

<220>
<221>  MISC_FEATURE
<222>  (147)..(147)
<223>  Xaa is a nonpolar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  Xaa is a non polar, basic residue, or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  Xaa is a polar residue

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (176)..(176)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  Xaa is a cysteine

<220>
<221>  MISC_FEATURE
<222>  (194)..(194)
<223>  Xaa is a constrained, basic, or polar residue

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  Xaa is a hydrophilic, acidic, basic, aliphatic or nonpolar 
       residue

<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa is an acidic, basic, hydrophilic, or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (199)..(199)
<223>  Xaa is an acidic, aliphatic, or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (200)..(200)
<223>  Xaa is an acidic or constrained residue

<220>
<221>  MISC_FEATURE
<222>  (202)..(202)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (206)..(206)
<223>  Xaa is a nonpolar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  Xaa is a basic residue

<220>
<221>  MISC_FEATURE
<222>  (223)..(223)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (250)..(250)
<223>  Xaa is a polar or nonpolar residue

<400>  161

Met Ser Xaa Arg Leu Asp Xaa Lys Val Ala Ile Ile Thr Gly Gly Thr 
1               5                   10                  15      


Xaa Gly Ile Gly Xaa Ala Ile Ala Xaa Lys Phe Val Xaa Glu Gly Ala 
            20                  25                  30          


Lys Val Met Ile Thr Gly Arg Xaa Ser Xaa Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Val Gly Xaa Pro Asp Gln Ile Gln Phe Phe Gln His Asp Ser 
    50                  55                  60                  


Ser Asp Glu Asp Gly Trp Thr Lys Leu Phe Xaa Ala Thr Glu Lys Ala 
65                  70                  75                  80  


Phe Gly Pro Val Ser Thr Leu Val Asn Asn Ala Gly Ile Xaa Xaa Xaa 
                85                  90                  95      


Lys Ser Val Glu Xaa Thr Thr Thr Xaa Glu Trp Xaa Lys Leu Xaa Xaa 
            100                 105                 110         


Xaa Asn Leu Asp Xaa Val Phe Phe Gly Thr Arg Leu Gly Ile Xaa Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Xaa Gly Xaa Val Gly Asp Pro Xaa Leu Gly Ala Tyr Xaa Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Xaa Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Xaa 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Xaa Ile Lys 
            180                 185                 190         


Thr Xaa Leu Val Xaa Xaa Xaa Xaa Gly Xaa Glu Glu Ala Xaa Ser Gln 
        195                 200                 205             


Arg Thr Xaa Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Xaa Ala 
    210                 215                 220                 


Tyr Ile Cys Val Tyr Leu Ala Ser Asn Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ser Glu Phe Val Val Asp Gly Gly Tyr Xaa Ala Gln 
                245                 250         


<210>  162
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Ketoreductase Sequence Formula with L. kefir backbone 
       Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is an acidic polar or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is a polar or non-polar residue

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is a non-polar, apliphatic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is a non-polar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is an acidic, nonpolar or polar residue

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is an acidic, aliphatic or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is a constrained, basic, or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa is an acidic or a nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa is a nonpolar or an acidic residue

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa is an acidic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa is a nonpolar or a polar residue

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is an aliphatic, non-polar, or acidic residue

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  Xaa is polar residue

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa is an acidic, non-polar, or a polar residue

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is an acidic or non-polar residue

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa is a hydrophilic, polar or constrained residue

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa is a non-polar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa is an acidic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  Xaa s a nonpolar or polar residue

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  Xaa is a basic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (145)..(145)
<223>  Xaa is a polar residue

<220>
<221>  MISC_FEATURE
<222>  (147)..(147)
<223>  Xaa is a nonpolar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  Xaa is a non polar, basic residue, or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  Xaa is a polar residue

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (176)..(176)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  Xaa is a cysteine

<220>
<221>  MISC_FEATURE
<222>  (194)..(194)
<223>  Xaa is a constrained, basic, or polar residue

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  Xaa is a hydrophilic, acidic, basic, aliphatic or nonpolar 
       residue

<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa is an acidic, basic, hydrophilic, or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (199)..(199)
<223>  Xaa is an acidic, aliphatic, or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (200)..(200)
<223>  Xaa is an acidic or constrained residue

<220>
<221>  MISC_FEATURE
<222>  (202)..(202)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (206)..(206)
<223>  Xaa is a nonpolar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  Xaa is a basic residue

<220>
<221>  MISC_FEATURE
<222>  (223)..(223)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (250)..(250)
<223>  Xaa is a polar or nonpolar residue

<400>  162

Met Thr Xaa Arg Leu Lys Xaa Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Xaa Gly Ile Gly Xaa Ala Ile Ala Xaa Lys Phe Val Xaa Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Xaa Ala Xaa Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Xaa Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Xaa Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Xaa Xaa Xaa 
                85                  90                  95      


Lys Ser Val Glu Xaa Thr Thr Thr Xaa Glu Trp Xaa Lys Leu Xaa Xaa 
            100                 105                 110         


Xaa Asn Leu Asp Xaa Val Phe Phe Gly Thr Arg Leu Gly Ile Xaa Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Xaa Gly Xaa Val Gly Asp Pro Xaa Leu Gly Ala Tyr Xaa Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Xaa Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Xaa 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Xaa Ile Lys 
            180                 185                 190         


Thr Xaa Leu Val Xaa Xaa Xaa Xaa Gly Xaa Glu Glu Met Xaa Ser Gln 
        195                 200                 205             


Arg Thr Xaa Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Xaa Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Xaa Ala Gln 
                245                 250         


<210>  163
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Ketoreductase Sequence Formula with L. minor backbone 
       Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is an acidic polar or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is a polar or non-polar residue

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is a non-polar, apliphatic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is a non-polar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is an acidic, nonpolar or polar residue

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is an acidic, aliphatic or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is a constrained, basic, or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa is an acidic or a nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa is a nonpolar or an acidic residue

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa is an acidic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa is a nonpolar or a polar residue

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is an aliphatic, non-polar, or acidic residue

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  Xaa is polar residue

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa is an acidic, non-polar, or a polar residue

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is an acidic or non-polar residue

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa is a hydrophilic, polar or constrained residue

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa is a non-polar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa is an acidic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  Xaa s a nonpolar or polar residue

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  Xaa is a basic or polar residue

<220>
<221>  MISC_FEATURE
<222>  (145)..(145)
<223>  Xaa is a polar residue

<220>
<221>  MISC_FEATURE
<222>  (147)..(147)
<223>  Xaa is a nonpolar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  Xaa is a non polar, basic residue, or hydrophilic residue

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  Xaa is a polar residue

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (176)..(176)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  Xaa is a cysteine

<220>
<221>  MISC_FEATURE
<222>  (194)..(194)
<223>  Xaa is a constrained, basic, or polar residue

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  Xaa is a hydrophilic, acidic, basic, aliphatic or nonpolar 
       residue

<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa is an acidic, basic, hydrophilic, or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (199)..(199)
<223>  Xaa is an acidic, aliphatic, or nonpolar residue

<220>
<221>  MISC_FEATURE
<222>  (200)..(200)
<223>  Xaa is an acidic or constrained residue

<220>
<221>  MISC_FEATURE
<222>  (202)..(202)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (206)..(206)
<223>  Xaa is a nonpolar, aromatic, or hydrophobic residue

<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  Xaa is a basic residue

<220>
<221>  MISC_FEATURE
<222>  (223)..(223)
<223>  Xaa is a nonpolar or aliphatic residue

<220>
<221>  MISC_FEATURE
<222>  (250)..(250)
<223>  Xaa is a polar or nonpolar residue

<400>  163

Met Thr Xaa Arg Leu Lys Xaa Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Xaa Gly Ile Gly Xaa Ala Ile Ala Xaa Lys Phe Val Xaa Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Xaa Ala Xaa Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Arg Ser Ile Gly Xaa Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Thr Gly Trp Thr Lys Leu Phe Xaa Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Xaa Xaa Xaa 
                85                  90                  95      


Lys Ser Val Glu Xaa Thr Thr Thr Xaa Glu Trp Xaa Lys Leu Xaa Xaa 
            100                 105                 110         


Xaa Asn Leu Asp Xaa Val Phe Phe Gly Thr Arg Leu Gly Ile Xaa Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Xaa Gly Xaa Val Gly Asp Pro Xaa Leu Gly Ala Tyr Xaa Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Xaa Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Xaa 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Xaa Ile Lys 
            180                 185                 190         


Thr Xaa Leu Val Xaa Xaa Xaa Xaa Gly Xaa Glu Glu Met Xaa Ser Gln 
        195                 200                 205             


Arg Thr Xaa Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Xaa Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Xaa Ala Gln 
                245                 250         


<210>  164
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  164

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Asn Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


<210>  165
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of L. kefir

<400>  165

Met Thr Asp Arg Leu Lys Ser Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Ser Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 


Ser Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Thr Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Cys Ile Lys 
            180                 185                 190         


Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Gly Ser Gln 
        195                 200                 205             


Arg Thr Arg Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 


Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln 
                245                 250         


