
                                SEQUENCE LISTING

<110> GlaxoSmithKline Biologicals S.A
      Institut Pasteur
      VOSS, Gerald Hermann
      LORIN, Clarisse Marie-Madeleine
      FEVRIER, Michle
      TANGY, Frdric

<120> Novel Method and Compositions
  

<130> VB63149

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3204
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence encoding HIV antigens Gag-RT-Nef
      ("GRN") from Clade B

<400> 1
atgggtgccc gagcttcggt actgtctggt ggagagctgg acagatggga gaaaattagg 60
ctgcgcccgg gaggcaaaaa gaaatacaag ctcaagcata tcgtgtgggc ctcgagggag 120
cttgaacggt ttgccgtgaa cccaggcctg ctggaaacat ctgagggatg tcgccagatc 180
ctggggcaat tgcagccatc cctccagacc gggagtgaag agctgaggtc cttgtataac 240
acagtggcta ccctctactg cgtacaccag aggatcgaga ttaaggatac caaggaggcc 300
ttggacaaaa ttgaggagga gcaaaacaag agcaagaaga aggcccagca ggcagctgct 360
gacactgggc atagcaacca ggtatcacag aactatccta ttgtccaaaa cattcagggc 420
cagatggttc atcaggccat cagcccccgg acgctcaatg cctgggtgaa ggttgtcgaa 480
gagaaggcct tttctcctga ggttatcccc atgttctccg ctttgagtga gggggccact 540
cctcaggacc tcaatacaat gcttaatacc gtgggcggcc atcaggccgc catgcaaatg 600
ttgaaggaga ctatcaacga ggaggcagcc gagtgggaca gagtgcatcc cgtccacgct 660
ggcccaatcg cgcccggaca gatgcgggag cctcgcggct ctgacattgc cggcaccacc 720
tctacactgc aagagcaaat cggatggatg accaacaatc ctcccatccc agttggagaa 780
atctataaac ggtggatcat cctgggcctg aacaagatcg tgcgcatgta ctctccgaca 840
tccatccttg acattagaca gggacccaaa gagcctttta gggattacgt cgaccggttt 900
tataagaccc tgcgagcaga gcaggcctct caggaggtca aaaactggat gacggagaca 960
ctcctggtac agaacgctaa ccccgactgc aaaacaatct tgaaggcact aggcccggct 1020
gccaccctgg aagagatgat gaccgcctgt cagggagtag gcggacccgg acacaaagcc 1080
agagtgttga tgggccccat cagtcccatc gagaccgtgc cggtgaagct gaaacccggg 1140
atggacggcc ccaaggtcaa gcagtggcca ctcaccgagg agaagatcaa ggccctggtg 1200
gagatctgca ccgagatgga gaaagagggc aagatcagca agatcgggcc ggagaaccca 1260
tacaacaccc ccgtgtttgc catcaagaag aaggacagca ccaagtggcg caagctggtg 1320
gatttccggg agctgaataa gcggacccag gatttctggg aggtccagct gggcatcccc 1380
catccggccg gcctgaagaa gaagaagagc gtgaccgtgc tggacgtggg cgacgcttac 1440
ttcagcgtcc ctctggacga ggactttaga aagtacaccg cctttaccat cccatctatc 1500
aacaacgaga cccctggcat cagatatcag tacaacgtcc tcccccaggg ctggaagggc 1560
tctcccgcca ttttccagag ctccatgacc aagatcctgg agccgtttcg gaagcagaac 1620
cccgatatcg tcatctacca gtacatggac gacctgtacg tgggctctga cctggaaatc 1680
gggcagcatc gcacgaagat tgaggagctg aggcagcatc tgctgagatg gggcctgacc 1740
actccggaca agaagcatca gaaggagccg ccattcctga agatgggcta cgagctccat 1800
cccgacaagt ggaccgtgca gcctatcgtc ctccccgaga aggacagctg gaccgtgaac 1860
gacatccaga agctggtggg caagctcaac tgggctagcc agatctatcc cgggatcaag 1920
gtgcgccagc tctgcaagct gctgcgcggc accaaggccc tgaccgaggt gattcccctc 1980
acggaggaag ccgagctcga gctggctgag aaccgggaga tcctgaagga gcccgtgcac 2040
ggcgtgtact atgacccctc caaggacctg atcgccgaaa tccagaagca gggccagggg 2100
cagtggacat accagattta ccaggagcct ttcaagaacc tcaagaccgg caagtacgcc 2160
cgcatgaggg gcgcccacac caacgatgtc aagcagctga ccgaggccgt ccagaagatc 2220
acgaccgagt ccatcgtgat ctgggggaag acacccaagt tcaagctgcc tatccagaag 2280
gagacctggg agacgtggtg gaccgaatat tggcaggcca cctggattcc cgagtgggag 2340
ttcgtgaata cacctcctct ggtgaagctg tggtaccagc tcgagaagga gcccatcgtg 2400
ggcgcggaga cattctacgt ggacggcgcg gccaaccgcg aaacaaagct cgggaaggcc 2460
gggtacgtca ccaaccgggg ccgccagaag gtcgtcaccc tgaccgacac caccaaccag 2520
aagacggagc tgcaggccat ctatctcgct ctccaggact ccggcctgga ggtgaacatc 2580
gtgacggaca gccagtacgc gctgggcatt attcaggccc agccggacca gtccgagagc 2640
gaactggtga accagattat cgagcagctg atcaagaaag agaaggtcta cctcgcctgg 2700
gtcccggccc ataagggcat tggcggcaac gagcaggtcg acaagctggt gagtgcgggg 2760
attagaaagg tgctgatggt gggttttcca gtcacacctc aggtaccttt aagaccaatg 2820
acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg actggaaggg 2880
ctaattcact cccaaagaag acaagatatc cttgatctgt ggatctacca cacacaaggc 2940
tacttccctg attggcagaa ctacacacca gggccagggg tcagatatcc actgaccttt 3000
ggatggtgct acaagctagt accagttgag ccagataagg tagaagaggc caataaagga 3060
gagaacacca gcttgttaca ccctgtgagc ctgcatggga tggatgaccc ggagagagaa 3120
gtgttagagt ggaggtttga cagccgccta gcatttcatc acgtggcccg agagctgcat 3180
ccggagtact tcaagaactg ctga                                        3204

<210> 2
<211> 1067
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence encoding HIV antigens
      Gag-RT-Nef ("GRN") from Clade B

<400> 2
Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp
 1               5                  10                  15      
Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys
            20                  25                  30          
His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro
        35                  40                  45              
Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu
    50                  55                  60                  
Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn
65                  70                  75                  80  
Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp
                85                  90                  95      
Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys
            100                 105                 110         
Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val
        115                 120                 125             
Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His
    130                 135                 140                 
Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu
145                 150                 155                 160 
Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser
                165                 170                 175     
Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly
            180                 185                 190         
Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu
        195                 200                 205             
Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala
    210                 215                 220                 
Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr
225                 230                 235                 240 
Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile
                245                 250                 255     
Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys
            260                 265                 270         
Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly
        275                 280                 285             
Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu
    290                 295                 300                 
Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr
305                 310                 315                 320 
Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala
                325                 330                 335     
Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly
            340                 345                 350         
Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Met Gly Pro Ile Ser
        355                 360                 365             
Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro
    370                 375                 380                 
Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val
385                 390                 395                 400 
Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly
                405                 410                 415     
Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp
            420                 425                 430         
Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg
        435                 440                 445             
Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly
    450                 455                 460                 
Leu Lys Lys Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr
465                 470                 475                 480 
Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr
                485                 490                 495     
Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn
            500                 505                 510         
Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser
        515                 520                 525             
Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val
    530                 535                 540                 
Ile Tyr Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile
545                 550                 555                 560 
Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg
                565                 570                 575     
Trp Gly Leu Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe
            580                 585                 590         
Leu Lys Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro
        595                 600                 605             
Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys
    610                 615                 620                 
Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Pro Gly Ile Lys
625                 630                 635                 640 
Val Arg Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu
                645                 650                 655     
Val Ile Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg
            660                 665                 670         
Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys
        675                 680                 685             
Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr
    690                 695                 700                 
Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala
705                 710                 715                 720 
Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala
                725                 730                 735     
Val Gln Lys Ile Thr Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro
            740                 745                 750         
Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Thr Trp Trp Thr
        755                 760                 765             
Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr
    770                 775                 780                 
Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val
785                 790                 795                 800 
Gly Ala Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu Thr Lys
                805                 810                 815     
Leu Gly Lys Ala Gly Tyr Val Thr Asn Arg Gly Arg Gln Lys Val Val
            820                 825                 830         
Thr Leu Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln Ala Ile Tyr
        835                 840                 845             
Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser
    850                 855                 860                 
Gln Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Gln Ser Glu Ser
865                 870                 875                 880 
Glu Leu Val Asn Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu Lys Val
                885                 890                 895     
Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly Asn Glu Gln
            900                 905                 910         
Val Asp Lys Leu Val Ser Ala Gly Ile Arg Lys Val Leu Met Val Gly
        915                 920                 925             
Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr Tyr Lys Ala
    930                 935                 940                 
Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu Gly
945                 950                 955                 960 
Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu Trp Ile Tyr
                965                 970                 975     
His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro
            980                 985                 990         
Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys Leu Val Pro
        995                 1000                1005            
Val Glu Pro Asp Lys Val Glu Glu Ala Asn Lys Gly Glu Asn Thr Ser
    1010                1015                1020                
Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro Glu Arg Glu
1025                1030                1035                1040
Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His His Val Ala
                1045                1050                1055    
Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys
            1060                1065        


<210> 3
<211> 4665
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence encoding HIV antigens
      Gag-RT-integrase-Nef ("GRIN") from Clade A

<400> 3
atggccgcca gagccagcat cctgagcggg ggcaagctgg acgcctggga gaagatcaga 60
ctgaggcctg gcggcaagaa gaagtaccgg ctgaagcacc tggtgtgggc cagcagagag 120
ctggatcgct tcgccctgaa tcctagcctg ctggagacca ccgagggctg ccagcagatc 180
atgaaccagc tgcagcccgc cgtgaaaacc ggcaccgagg agatcaagag cctgttcaac 240
accgtggcca ccctgtactg cgtgcaccag cggatcgacg tgaaggatac caaggaggcc 300
ctggacaaga tcgaggagat ccagaacaag agcaagcaga aaacccagca ggccgctgcc 360
gacaccggcg acagcagcaa agtgagccag aactacccca tcatccagaa tgcccagggc 420
cagatgatcc accagaacct gagccccaga accctgaatg cctgggtgaa agtgatcgag 480
gaaaaggcct tcagccccga agtgatccct atgttcagcg ccctgagcga gggcgccacc 540
ccccaggacc tgaacgtgat gctgaacatt gtgggcggac accaggccgc catgcagatg 600
ctgaaggaca ccatcaatga ggaggccgcc gagtgggaca gactgcaccc cgtgcaggcc 660
ggacccatcc cccctggcca gatcagagag cccagaggca gcgacatcgc cggcaccacc 720
tccacccctc aagaacagct gcagtggatg accggcaacc ctcccatccc tgtgggcaac 780
atctacaagc ggtggatcat cctgggcctg aacaagattg tgcggatgta cagccccgtg 840
tccatcctgg atatcaagca gggccccaag gagcccttca gagactacgt ggaccggttc 900
ttcaaggccc tgagagccga gcaggccacc caggacgtga agggctggat gaccgagacc 960
ctgctggtgc agaacgccaa ccccgactgc aagagcatcc tgaaggccct gggcagcggc 1020
gccacactgg aggagatgat gaccgcctgc cagggagtgg gcggacccgg ccacaaggcc 1080
agagtgctgg ccgaggccat gagccaggcc cagcagacca acatcatgat gcagcggggc 1140
aacttcagag gccagaagcg gatcaagtgc ttcaactgcg gcaaggaggg ccacctggcc 1200
agaaactgca gagcccccag gaagaagggc tgctggaagt gtggcaagga agggcaccag 1260
atgaaggact gcaccgagag gcaggccaat ttcctgggca agatttggcc tagcagcaag 1320
ggcagacccg gcaatttccc ccagagcaga cccgagccca ccgcccctcc cgccgagctg 1380
ttcggcatgg gcgagggcat cgccagcctg cccaagcagg agcagaagga cagagagcag 1440
gtgccccccc tggtgtccct gaagtccctg ttcggcaacg atcctctgag ccagggatcc 1500
cccatcagcc ccatcgagac cgtgcccgtg accctgaagc ccggcatgga tggccccaaa 1560
gtgaaacagt ggcccctgac cgaggagaag attaaggccc tgaccgaaat ctgtaccgag 1620
atggagaagg agggcaagat cagcaagatc ggccccgaga acccctacaa cacccccatc 1680
ttcgccatca agaagaagga cagcaccaag tggcggaaac tggtggactt ccgggagctg 1740
aacaagagga cccaggactt ctgggaagtg cagctgggca tcccccaccc tgccggcctg 1800
aagaagaaga agtccgtgac agtgctggat gtgggcgacg cctacttcag cgtgcccctg 1860
gacgagaact tcaggaagta caccgccttc accatcccca gcaccaacaa cgagaccccc 1920
ggagtgagat accagtacaa cgtgctgcct cagggctgga agggcagccc cgccatcttc 1980
cagagcagca tgaccaagat cctggagccc ttccggagca agaaccccga gatcatcatc 2040
taccagtaca tggccgccct gtatgtgggc agcgatctgg agatcggcca gcacaggacc 2100
aagatcgaag agctgagggc ccacctgctg agctggggct tcaccacccc cgataagaag 2160
caccagaagg agcccccttt cctgtggatg ggctacgagc tgcaccccga taagtggacc 2220
gtgcagccca tcatgctgcc cgataaggag agctggaccg tgaacgacat ccagaaactg 2280
gtgggcaagc tgaattgggc cagccaaatc tacgccggca ttaaagtgaa gcagctgtgc 2340
aggctgctga gaggcgccaa agccctgaca gacatcgtga cactgacaga ggaggccgag 2400
ctggagctgg ccgagaacag ggagatcctg aaggaccccg tgcacggcgt gtactacgac 2460
cccagcaagg acctggtggc cgagattcag aagcagggcc aggaccagtg gacctaccaa 2520
atctaccagg agcctttcaa gaacctgaaa accgggaagt acgccaggaa gagaagcgcc 2580
cacaccaacg atgtgaggca gctggccgaa gtggtgcaga aagtggctat ggagagcatc 2640
gtgatctggg gcaagacccc caagttcaag ctgcccatcc agaaggagac ctgggaaacc 2700
tggtggatgg actactggca ggccacctgg attcctgagt gggagttcgt gaacaccccc 2760
cctctggtga agctgtggta tcagctggag aaggacccca tcctgggcgc cgagaccttc 2820
tacgtggacg gagccgccaa tagagagacc aagctgggca aggccggcta cgtgaccgac 2880
agaggcagac agaaagtggt gtctctgacc gagacaacca accagaaaac cgagctgcac 2940
gccatcctgc tggccctgca ggacagcggc agcgaagtga acatcgtgac cgactcccag 3000
tacgccctgg gcatcattca ggcccagccc gatagaagcg agagcgagct ggtgaaccag 3060
atcatcgaga agctgatcgg caaggacaaa atctacctga gctgggtgcc cgcccacaag 3120
ggcatcggcg gcaacgagca ggtggacaag ctggtgtcca gcggcatccg gaaagtgctg 3180
tttctggacg gcatcgacaa ggcccaggag gaccacgaga gataccacag caactggcgg 3240
acaatggcca gcgacttcaa cctgcctccc atcgtggcca aggagatcgt ggccagctgc 3300
gataagtgtc agctgaaggg cgaggccatg cacggccagg tggactgcag ccctggcatc 3360
tggcagctgg cctgcaccca cctggagggc aaagtgattc tggtggccgt gcacgtggcc 3420
agcggctaca tcgaggccga agtgattccc gccgagaccg gccaggagac cgcctacttc 3480
ctgctgaagc tggccggcag atggcccgtg aaagtggtgc acaccgccaa cggcagcaac 3540
ttcacctctg ccgccgtgaa ggccgcctgt tggtgggcca atatccagca ggagttcggc 3600
atcccctaca accctcagag ccagggcgtg gtggccagca tgaacaagga gctgaagaag 3660
atcatcggcc aggtgaggga ccaggccgag cacctgaaaa cagccgtgca gatggccgtg 3720
ttcatccaca acttcaagcg gaagggcggc attggcggct acagcgccgg agagcggatc 3780
atcgacatca tcgccaccga tatccagacc aaggaactgc agaagcagat caccaagatt 3840
cagaacttca gagtgtacta ccgggacagc agggacccca tctggaaggg ccctgccaag 3900
ctgctgtgga agggcgaagg cgccgtggtg atccaggaca acagcgacat caaagtggtg 3960
ccccggagga aggccaagat tctgcgggac tacggcaaac agatggccgg cgatgactgc 4020
gtggccggca ggcaggatga ggacagatct atgggcggca agtggtccaa gggcagcatt 4080
gtgggctggc ccgagatccg ggagagaatg agaagagccc ctgccgccgc tcctggagtg 4140
ggcgccgtgt ctcaggatct ggataagcac ggcgccatca ccagcagcaa catcaacaac 4200
cccagctgtg tgtggctgga ggcccaggaa gaggaggaag tgggcttccc tgtgagaccc 4260
caggtgcccc tgagacccat gacctacaag ggcgccttcg acctgagcca cttcctgaag 4320
gagaagggcg gcctggacgg cctgatctac agccggaagc ggcaggagat cctggatctg 4380
tgggtgtacc acacccaggg ctacttcccc gactggcaga attacacccc tggccctgga 4440
gtgcggtatc ccctgacctt cggctggtgc ttcaagctgg tgcctatgga gcccgacgaa 4500
gtggagaagg ccacagaggg cgagaacaac agcctgctgc accctatctg ccagcacggc 4560
atggacgatg aggagcggga agtgctgatc tggaagttcg acagcaggct ggccctgaag 4620
cacagagccc aggaactgca cccagagttc tacaaggact gctga                 4665

<210> 4
<211> 1554
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence encoding HIV antigens
      Gag-RT-integrase-Nef ("GRIN") from Clade A

<400> 4
Met Ala Ala Arg Ala Ser Ile Leu Ser Gly Gly Lys Leu Asp Ala Trp
 1               5                  10                  15      
Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys
            20                  25                  30          
His Leu Val Trp Ala Ser Arg Glu Leu Asp Arg Phe Ala Leu Asn Pro
        35                  40                  45              
Ser Leu Leu Glu Thr Thr Glu Gly Cys Gln Gln Ile Met Asn Gln Leu
    50                  55                  60                  
Gln Pro Ala Val Lys Thr Gly Thr Glu Glu Ile Lys Ser Leu Phe Asn
65                  70                  75                  80  
Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Asp Val Lys Asp
                85                  90                  95      
Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Ile Gln Asn Lys Ser Lys
            100                 105                 110         
Gln Lys Thr Gln Gln Ala Ala Ala Asp Thr Gly Asp Ser Ser Lys Val
        115                 120                 125             
Ser Gln Asn Tyr Pro Ile Ile Gln Asn Ala Gln Gly Gln Met Ile His
    130                 135                 140                 
Gln Asn Leu Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu
145                 150                 155                 160 
Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser
                165                 170                 175     
Glu Gly Ala Thr Pro Gln Asp Leu Asn Val Met Leu Asn Ile Val Gly
            180                 185                 190         
Gly His Gln Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu
        195                 200                 205             
Ala Ala Glu Trp Asp Arg Leu His Pro Val Gln Ala Gly Pro Ile Pro
    210                 215                 220                 
Pro Gly Gln Ile Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr
225                 230                 235                 240 
Ser Thr Pro Gln Glu Gln Leu Gln Trp Met Thr Gly Asn Pro Pro Ile
                245                 250                 255     
Pro Val Gly Asn Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys
            260                 265                 270         
Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Lys Gln Gly
        275                 280                 285             
Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Ala Leu
    290                 295                 300                 
Arg Ala Glu Gln Ala Thr Gln Asp Val Lys Gly Trp Met Thr Glu Thr
305                 310                 315                 320 
Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Ser Ile Leu Lys Ala
                325                 330                 335     
Leu Gly Ser Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly
            340                 345                 350         
Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser
        355                 360                 365             
Gln Ala Gln Gln Thr Asn Ile Met Met Gln Arg Gly Asn Phe Arg Gly
    370                 375                 380                 
Gln Lys Arg Ile Lys Cys Phe Asn Cys Gly Lys Glu Gly His Leu Ala
385                 390                 395                 400 
Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys
                405                 410                 415     
Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu
            420                 425                 430         
Gly Lys Ile Trp Pro Ser Ser Lys Gly Arg Pro Gly Asn Phe Pro Gln
        435                 440                 445             
Ser Arg Pro Glu Pro Thr Ala Pro Pro Ala Glu Leu Phe Gly Met Gly
    450                 455                 460                 
Glu Gly Ile Ala Ser Leu Pro Lys Gln Glu Gln Lys Asp Arg Glu Gln
465                 470                 475                 480 
Val Pro Pro Leu Val Ser Leu Lys Ser Leu Phe Gly Asn Asp Pro Leu
                485                 490                 495     
Ser Gln Gly Ser Pro Ile Ser Pro Ile Glu Thr Val Pro Val Thr Leu
            500                 505                 510         
Lys Pro Gly Met Asp Gly Pro Lys Val Lys Gln Trp Pro Leu Thr Glu
        515                 520                 525             
Glu Lys Ile Lys Ala Leu Thr Glu Ile Cys Thr Glu Met Glu Lys Glu
    530                 535                 540                 
Gly Lys Ile Ser Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Ile
545                 550                 555                 560 
Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp
                565                 570                 575     
Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu
            580                 585                 590         
Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val
        595                 600                 605             
Leu Asp Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Asn Phe
    610                 615                 620                 
Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu Thr Pro
625                 630                 635                 640 
Gly Val Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser
                645                 650                 655     
Pro Ala Ile Phe Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg
            660                 665                 670         
Ser Lys Asn Pro Glu Ile Ile Ile Tyr Gln Tyr Met Ala Ala Leu Tyr
        675                 680                 685             
Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Thr Lys Ile Glu Glu
    690                 695                 700                 
Leu Arg Ala His Leu Leu Ser Trp Gly Phe Thr Thr Pro Asp Lys Lys
705                 710                 715                 720 
His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro
                725                 730                 735     
Asp Lys Trp Thr Val Gln Pro Ile Met Leu Pro Asp Lys Glu Ser Trp
            740                 745                 750         
Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser
        755                 760                 765             
Gln Ile Tyr Ala Gly Ile Lys Val Lys Gln Leu Cys Arg Leu Leu Arg
    770                 775                 780                 
Gly Ala Lys Ala Leu Thr Asp Ile Val Thr Leu Thr Glu Glu Ala Glu
785                 790                 795                 800 
Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Asp Pro Val His Gly
                805                 810                 815     
Val Tyr Tyr Asp Pro Ser Lys Asp Leu Val Ala Glu Ile Gln Lys Gln
            820                 825                 830         
Gly Gln Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn
        835                 840                 845             
Leu Lys Thr Gly Lys Tyr Ala Arg Lys Arg Ser Ala His Thr Asn Asp
    850                 855                 860                 
Val Arg Gln Leu Ala Glu Val Val Gln Lys Val Ala Met Glu Ser Ile
865                 870                 875                 880 
Val Ile Trp Gly Lys Thr Pro Lys Phe Lys Leu Pro Ile Gln Lys Glu
                885                 890                 895     
Thr Trp Glu Thr Trp Trp Met Asp Tyr Trp Gln Ala Thr Trp Ile Pro
            900                 905                 910         
Glu Trp Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln
        915                 920                 925             
Leu Glu Lys Asp Pro Ile Leu Gly Ala Glu Thr Phe Tyr Val Asp Gly
    930                 935                 940                 
Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val Thr Asp
945                 950                 955                 960 
Arg Gly Arg Gln Lys Val Val Ser Leu Thr Glu Thr Thr Asn Gln Lys
                965                 970                 975     
Thr Glu Leu His Ala Ile Leu Leu Ala Leu Gln Asp Ser Gly Ser Glu
            980                 985                 990         
Val Asn Ile Val Thr Asp Ser Gln Tyr Ala Leu Gly Ile Ile Gln Ala
        995                 1000                1005            
Gln Pro Asp Arg Ser Glu Ser Glu Leu Val Asn Gln Ile Ile Glu Lys
    1010                1015                1020                
Leu Ile Gly Lys Asp Lys Ile Tyr Leu Ser Trp Val Pro Ala His Lys
1025                1030                1035                1040
Gly Ile Gly Gly Asn Glu Gln Val Asp Lys Leu Val Ser Ser Gly Ile
                1045                1050                1055    
Arg Lys Val Leu Phe Leu Asp Gly Ile Asp Lys Ala Gln Glu Asp His
            1060                1065                1070        
Glu Arg Tyr His Ser Asn Trp Arg Thr Met Ala Ser Asp Phe Asn Leu
        1075                1080                1085            
Pro Pro Ile Val Ala Lys Glu Ile Val Ala Ser Cys Asp Lys Cys Gln
    1090                1095                1100                
Leu Lys Gly Glu Ala Met His Gly Gln Val Asp Cys Ser Pro Gly Ile
1105                1110                1115                1120
Trp Gln Leu Ala Cys Thr His Leu Glu Gly Lys Val Ile Leu Val Ala
                1125                1130                1135    
Val His Val Ala Ser Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu
            1140                1145                1150        
Thr Gly Gln Glu Thr Ala Tyr Phe Leu Leu Lys Leu Ala Gly Arg Trp
        1155                1160                1165            
Pro Val Lys Val Val His Thr Ala Asn Gly Ser Asn Phe Thr Ser Ala
    1170                1175                1180                
Ala Val Lys Ala Ala Cys Trp Trp Ala Asn Ile Gln Gln Glu Phe Gly
1185                1190                1195                1200
Ile Pro Tyr Asn Pro Gln Ser Gln Gly Val Val Ala Ser Met Asn Lys
                1205                1210                1215    
Glu Leu Lys Lys Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu
            1220                1225                1230        
Lys Thr Ala Val Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys
        1235                1240                1245            
Gly Gly Ile Gly Gly Tyr Ser Ala Gly Glu Arg Ile Ile Asp Ile Ile
    1250                1255                1260                
Ala Thr Asp Ile Gln Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile
1265                1270                1275                1280
Gln Asn Phe Arg Val Tyr Tyr Arg Asp Ser Arg Asp Pro Ile Trp Lys
                1285                1290                1295    
Gly Pro Ala Lys Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln
            1300                1305                1310        
Asp Asn Ser Asp Ile Lys Val Val Pro Arg Arg Lys Ala Lys Ile Leu
        1315                1320                1325            
Arg Asp Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys Val Ala Gly Arg
    1330                1335                1340                
Gln Asp Glu Asp Arg Ser Met Gly Gly Lys Trp Ser Lys Gly Ser Ile
1345                1350                1355                1360
Val Gly Trp Pro Glu Ile Arg Glu Arg Met Arg Arg Ala Pro Ala Ala
                1365                1370                1375    
Ala Pro Gly Val Gly Ala Val Ser Gln Asp Leu Asp Lys His Gly Ala
            1380                1385                1390        
Ile Thr Ser Ser Asn Ile Asn Asn Pro Ser Cys Val Trp Leu Glu Ala
        1395                1400                1405            
Gln Glu Glu Glu Glu Val Gly Phe Pro Val Arg Pro Gln Val Pro Leu
    1410                1415                1420                
Arg Pro Met Thr Tyr Lys Gly Ala Phe Asp Leu Ser His Phe Leu Lys
1425                1430                1435                1440
Glu Lys Gly Gly Leu Asp Gly Leu Ile Tyr Ser Arg Lys Arg Gln Glu
                1445                1450                1455    
Ile Leu Asp Leu Trp Val Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp
            1460                1465                1470        
Gln Asn Tyr Thr Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly
        1475                1480                1485            
Trp Cys Phe Lys Leu Val Pro Met Glu Pro Asp Glu Val Glu Lys Ala
    1490                1495                1500                
Thr Glu Gly Glu Asn Asn Ser Leu Leu His Pro Ile Cys Gln His Gly
1505                1510                1515                1520
Met Asp Asp Glu Glu Arg Glu Val Leu Ile Trp Lys Phe Asp Ser Arg
                1525                1530                1535    
Leu Ala Leu Lys His Arg Ala Gln Glu Leu His Pro Glu Phe Tyr Lys
            1540                1545                1550        
Asp Cys
        


<210> 5
<211> 2025
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence encoding gp140 from HIV Clade A

<400> 5
atgagggtga tggagatcca gcggaactgc cagcacctgc tgagatgggg catcatgatc 60
ctgggcatga ttatcatctg cagcaccgcc gacaacctgt gggtgaccgt gtactacggc 120
gtgcctgtgt ggagagatgc cgagaccacc ctgttctgcg ccagcgacgc caaggcctac 180
agcaccgaga agcacaatgt gtgggccacc cacgcctgcg tgcctaccga tcccaaccct 240
caggagatcc ccctggacaa cgtgaccgag gagttcaaca tgtggaagaa caacatggtg 300
gaccagatgc acgaggacat catcagcctg tgggaccaga gcctgaagcc ctgcgtgcag 360
ctgacccccc tgtgcgtgac cctgaactgc agcaacgcca gagtgaacgc caccttcaac 420
tccaccgagg acagggaggg catgaagaac tgcagcttca acatgaccac cgagctgcgg 480
gataagaagc agcaggtgta cagcctgttc taccggctgg acatcgagaa gatcaacagc 540
agcaacaaca acagcgagta ccggctggtg aactgcaata ccagcgccat cacccaggcc 600
tgccctaagg tgaccttcga gcccatcccc atccactact gcgcccctgc cggcttcgcc 660
atcctgaagt gcaacgacac cgagttcaat ggcaccggcc cctgcaagaa tgtgagcacc 720
gtgcagtgca cccacggcat caagcccgtg gtgtccaccc agctgctgct gaacggcagc 780
ctggccgaga gagaagtgcg gatcaggagc gagaacatcg ccaacaacgc caagaacatc 840
atcgtgcagt tcgccagccc cgtgaagatc aactgcatcc ggcccaacaa caatacccgg 900
aagagctaca gaatcggccc tggccagacc ttctacgcca ccgacattgt gggcgacatc 960
agacaggccc actgcaacgt gtccaggacc gactggaaca acaccctgag actggtggcc 1020
aaccagctgc ggaagtactt cagcaacaag accatcatct tcaccaacag cagcggcgga 1080
gacctggaga tcaccaccca cagcttcaat tgtggcggcg agttcttcta ctgcaacacc 1140
tccggcctgt tcaatagcac ctggaccacc aacaacatgc aggagtccaa cgacaccagc 1200
aacggcacca tcaccctgcc ctgccggatc aagcagatca tccggatgtg gcagcgcgtg 1260
ggccaggcca tgtacgcccc tcccatcgag ggcgtgattc gctgcgagag caacatcacc 1320
ggcctgatcc tgaccagaga tggcggcaac aacaattccg ccaacgagac cttcagacct 1380
ggcggcggag atatccggga caactggcgg agcgagctgt acaagtacaa ggtggtgaag 1440
atcgagcccc tgggcgtggc ccccaccaga gccaagagaa gagtggtgga gcgggagaag 1500
agagccgtgg gcatcggcgc cgtgtttctg ggcttcctgg gagccgccgg atctacaatg 1560
ggagccgcca gcatcaccct gaccgtgcag gccagacagc tgctgagcgg catcgtgcag 1620
cagcagagca atctgctgag agccatcgag gcccagcagc agctgctgaa gctgacagtg 1680
tggggcatca agcagctgca ggccagggtg ctggccgtgg agagatacct gagggaccag 1740
cagctcctgg gcatctgggg ctgcagcggc aagctgatct gcaccaccaa cgtgccctgg 1800
aatagcagct ggagcaacaa gagctacgac gacatctggc agaacatgac ctggctgcag 1860
tgggacaagg agatcagcaa ctacaccgac atcatctaca gcctgatcga ggagagccag 1920
aaccagcagg agaagaacga gcaggatctg ctggccctgg acaagtgggc caacctgtgg 1980
aactggttcg acatcagcaa gtggctgtgg tacatcagat cttga                 2025

<210> 6
<211> 674
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence encoding gp140 from HIV Clade
      A

<400> 6
Met Arg Val Met Glu Ile Gln Arg Asn Cys Gln His Leu Leu Arg Trp
 1               5                  10                  15      
Gly Ile Met Ile Leu Gly Met Ile Ile Ile Cys Ser Thr Ala Asp Asn
            20                  25                  30          
Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu
        35                  40                  45              
Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Ser Thr Glu Lys
    50                  55                  60                  
His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro
65                  70                  75                  80  
Gln Glu Ile Pro Leu Asp Asn Val Thr Glu Glu Phe Asn Met Trp Lys
                85                  90                  95      
Asn Asn Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp
            100                 105                 110         
Gln Ser Leu Lys Pro Cys Val Gln Leu Thr Pro Leu Cys Val Thr Leu
        115                 120                 125             
Asn Cys Ser Asn Ala Arg Val Asn Ala Thr Phe Asn Ser Thr Glu Asp
    130                 135                 140                 
Arg Glu Gly Met Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg
145                 150                 155                 160 
Asp Lys Lys Gln Gln Val Tyr Ser Leu Phe Tyr Arg Leu Asp Ile Glu
                165                 170                 175     
Lys Ile Asn Ser Ser Asn Asn Asn Ser Glu Tyr Arg Leu Val Asn Cys
            180                 185                 190         
Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro
        195                 200                 205             
Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys
    210                 215                 220                 
Asn Asp Thr Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr
225                 230                 235                 240 
Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu
                245                 250                 255     
Leu Asn Gly Ser Leu Ala Glu Arg Glu Val Arg Ile Arg Ser Glu Asn
            260                 265                 270         
Ile Ala Asn Asn Ala Lys Asn Ile Ile Val Gln Phe Ala Ser Pro Val
        275                 280                 285             
Lys Ile Asn Cys Ile Arg Pro Asn Asn Asn Thr Arg Lys Ser Tyr Arg
    290                 295                 300                 
Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Asp Ile Val Gly Asp Ile
305                 310                 315                 320 
Arg Gln Ala His Cys Asn Val Ser Arg Thr Asp Trp Asn Asn Thr Leu
                325                 330                 335     
Arg Leu Val Ala Asn Gln Leu Arg Lys Tyr Phe Ser Asn Lys Thr Ile
            340                 345                 350         
Ile Phe Thr Asn Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser
        355                 360                 365             
Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe
    370                 375                 380                 
Asn Ser Thr Trp Thr Thr Asn Asn Met Gln Glu Ser Asn Asp Thr Ser
385                 390                 395                 400 
Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Arg Met
                405                 410                 415     
Trp Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Glu Gly Val
            420                 425                 430         
Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly
        435                 440                 445             
Gly Asn Asn Asn Ser Ala Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp
    450                 455                 460                 
Ile Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys
465                 470                 475                 480 
Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg Arg Val Val
                485                 490                 495     
Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe
            500                 505                 510         
Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr
        515                 520                 525             
Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn
    530                 535                 540                 
Leu Leu Arg Ala Ile Glu Ala Gln Gln Gln Leu Leu Lys Leu Thr Val
545                 550                 555                 560 
Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr
                565                 570                 575     
Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu
            580                 585                 590         
Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser
        595                 600                 605             
Tyr Asp Asp Ile Trp Gln Asn Met Thr Trp Leu Gln Trp Asp Lys Glu
    610                 615                 620                 
Ile Ser Asn Tyr Thr Asp Ile Ile Tyr Ser Leu Ile Glu Glu Ser Gln
625                 630                 635                 640 
Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp
                645                 650                 655     
Ala Asn Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile
            660                 665                 670         
Arg Ser
        


<210> 7
<211> 1545
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence encoding gp120 from HIV Clade B

<400> 7
atgaaagtga aggagaccag gaagaattat cagcacttgt ggagatgggg caccatgctc 60
cttgggatgt tgatgatctg tagtgctgca gaacaattgt gggtcacagt ctattatggg 120
gtacctgtgt ggaaagaagc aactaccact ctattctgtg catcagatgc taaagcatat 180
gatacagagg tacataatgt ttgggccaca catgcctgtg tacccacaga ccccaaccca 240
caagaagtag tattgggaaa tgtgacagaa tattttaaca tgtggaaaaa taacatggta 300
gaccagatgc atgaggatat aatcagttta tgggatcaaa gcttgaagcc atgtgtaaaa 360
ttaaccccac tctgtgttac tttagattgc gatgatgtga ataccactaa tagtactact 420
accactagta atggttggac aggagaaata aggaaaggag aaataaaaaa ctgctctttt 480
aatatcacca caagcataag agataaggtt caaaaagaat atgcactttt ttataacctt 540
gatgtagtac caatagatga tgataatgct actaccaaaa ataaaactac tagaaacttt 600
aggttgatac attgtaactc ctcagtcatg acacaggcct gtccaaaggt atcatttgaa 660
ccaattccca tacattattg tgccccggct ggttttgcga ttctgaagtg taacaataag 720
acgtttgatg gaaaaggact atgtacaaat gtcagcacag tacaatgtac acatggaatt 780
aggccagtag tgtcaactca actgctgtta aatggcagtc tagcagaaga agaggtagta 840
attagatctg acaatttcat ggacaatact aaaaccataa tagtacagct gaatgaatct 900
gtagcaatta attgtacaag acccaacaac aatacaagaa aaggtataca tataggacca 960
gggagagcct tttatgcagc aagaaaaata ataggagata taagacaagc acattgtaac 1020
cttagtagag cacaatggaa taacacttta aaacagatag ttataaaatt aagagaacac 1080
tttgggaata aaacaataaa atttaatcaa tcctcaggag gggacccaga aattgtaagg 1140
catagtttta attgtggagg ggaatttttc tactgtgata caacacaact gtttaatagt 1200
acttggaatg gtactgaagg aaataacact gaaggaaata gcacaatcac actcccatgt 1260
agaataaaac aaattataaa catgtggcag gaagtaggaa aagcaatgta tgcccctccc 1320
atcggaggac aaattagatg ttcatcaaat attacagggc tgctattaac aagagatggt 1380
ggtaccgaag ggaatgggac agagaatgag acagagatct tcagacctgg aggaggagat 1440
atgagggaca attggagaag tgaattatat aaatataaag tagtaaaagt tgaaccacta 1500
ggagtagcac ccaccagggc aaagagaaga gtggtgcaga gataa                 1545

<210> 8
<211> 514
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence encoding gp120 from HIV Clade
      B

<400> 8
Met Lys Val Lys Glu Thr Arg Lys Asn Tyr Gln His Leu Trp Arg Trp
 1               5                  10                  15      
Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln
            20                  25                  30          
Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr
        35                  40                  45              
Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val
    50                  55                  60                  
His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro
65                  70                  75                  80  
Gln Glu Val Val Leu Gly Asn Val Thr Glu Tyr Phe Asn Met Trp Lys
                85                  90                  95      
Asn Asn Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp
            100                 105                 110         
Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu
        115                 120                 125             
Asp Cys Asp Asp Val Asn Thr Thr Asn Ser Thr Thr Thr Thr Ser Asn
    130                 135                 140                 
Gly Trp Thr Gly Glu Ile Arg Lys Gly Glu Ile Lys Asn Cys Ser Phe
145                 150                 155                 160 
Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu
                165                 170                 175     
Phe Tyr Asn Leu Asp Val Val Pro Ile Asp Asp Asp Asn Ala Thr Thr
            180                 185                 190         
Lys Asn Lys Thr Thr Arg Asn Phe Arg Leu Ile His Cys Asn Ser Ser
        195                 200                 205             
Val Met Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile
    210                 215                 220                 
His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys
225                 230                 235                 240 
Thr Phe Asp Gly Lys Gly Leu Cys Thr Asn Val Ser Thr Val Gln Cys
                245                 250                 255     
Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly
            260                 265                 270         
Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Asp Asn Phe Met Asp
        275                 280                 285             
Asn Thr Lys Thr Ile Ile Val Gln Leu Asn Glu Ser Val Ala Ile Asn
    290                 295                 300                 
Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Gly Ile His Ile Gly Pro
305                 310                 315                 320 
Gly Arg Ala Phe Tyr Ala Ala Arg Lys Ile Ile Gly Asp Ile Arg Gln
                325                 330                 335     
Ala His Cys Asn Leu Ser Arg Ala Gln Trp Asn Asn Thr Leu Lys Gln
            340                 345                 350         
Ile Val Ile Lys Leu Arg Glu His Phe Gly Asn Lys Thr Ile Lys Phe
        355                 360                 365             
Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Arg His Ser Phe Asn
    370                 375                 380                 
Cys Gly Gly Glu Phe Phe Tyr Cys Asp Thr Thr Gln Leu Phe Asn Ser
385                 390                 395                 400 
Thr Trp Asn Gly Thr Glu Gly Asn Asn Thr Glu Gly Asn Ser Thr Ile
                405                 410                 415     
Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val
            420                 425                 430         
Gly Lys Ala Met Tyr Ala Pro Pro Ile Gly Gly Gln Ile Arg Cys Ser
        435                 440                 445             
Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Thr Glu Gly
    450                 455                 460                 
Asn Gly Thr Glu Asn Glu Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp
465                 470                 475                 480 
Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys
                485                 490                 495     
Val Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg Arg Val Val
            500                 505                 510         
Gln Arg
        


<210> 9
<211> 2178
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence encoding M72 fusion protein from TB

<400> 9
atgcatcaca cggccgcgtc cgataacttc cagctgtccc agggtgggca gggattcgcc 60
attccgatcg ggcaggcgat ggcgatcgcg ggccagatcc gatcgggtgg ggggtcaccc 120
accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180
ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240
ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300
gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360
ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt catggtggat 420
ttcggggcgt taccaccgga gatcaactcc gcgaggatgt acgccggccc gggttcggcc 480
tcgctggtgg ccgcggctca gatgtgggac agcgtggcga gtgacctgtt ttcggccgcg 540
tcggcgtttc agtcggtggt ctggggtctg acggtggggt cgtggatagg ttcgtcggcg 600
ggtctgatgg tggcggcggc ctcgccgtat gtggcgtgga tgagcgtcac cgcggggcag 660
gccgagctga ccgccgccca ggtccgggtt gctgcggcgg cctacgagac ggcgtatggg 720
ctgacggtgc ccccgccggt gatcgccgag aaccgtgctg aactgatgat tctgatagcg 780
accaacctct tggggcaaaa caccccggcg atcgcggtca acgaggccga atacggcgag 840
atgtgggccc aagacgccgc cgcgatgttt ggctacgccg cggcgacggc gacggcgacg 900
gcgacgttgc tgccgttcga ggaggcgccg gagatgacca gcgcgggtgg gctcctcgag 960
caggccgccg cggtcgagga ggcctccgac accgccgcgg cgaaccagtt gatgaacaat 1020
gtgccccagg cgctgcaaca gctggcccag cccacgcagg gcaccacgcc ttcttccaag 1080
ctgggtggcc tgtggaagac ggtctcgccg catcggtcgc cgatcagcaa catggtgtcg 1140
atggccaaca accacatgtc gatgaccaac tcgggtgtgt cgatgaccaa caccttgagc 1200
tcgatgttga agggctttgc tccggcggcg gccgcccagg ccgtgcaaac cgcggcgcaa 1260
aacggggtcc gggcgatgag ctcgctgggc agctcgctgg gttcttcggg tctgggcggt 1320
ggggtggccg ccaacttggg tcgggcggcc tcggtcggtt cgttgtcggt gccgcaggcc 1380
tgggccgcgg ccaaccaggc agtcaccccg gcggcgcggg cgctgccgct gaccagcctg 1440
accagcgccg cggaaagagg gcccgggcag atgctgggcg ggctgccggt ggggcagatg 1500
ggcgccaggg ccggtggtgg gctcagtggt gtgctgcgtg ttccgccgcg accctatgtg 1560
atgccgcatt ctccggcagc cggcgatatc gccccgccgg ccttgtcgca ggaccggttc 1620
gccgacttcc ccgcgctgcc cctcgacccg tccgcgatgg tcgcccaagt ggggccacag 1680
gtggtcaaca tcaacaccaa actgggctac aacaacgccg tgggcgccgg gaccggcatc 1740
gtcatcgatc ccaacggtgt cgtgctgacc aacaaccacg tgatcgcggg cgccaccgac 1800
atcaatgcgt tcagcgtcgg ctccggccaa acctacggcg tcgatgtggt cgggtatgac 1860
cgcacccagg atgtcgcggt gctgcagctg cgcggtgccg gtggcctgcc gtcggcggcg 1920
atcggtggcg gcgtcgcggt tggtgagccc gtcgtcgcga tgggcaacag cggtgggcag 1980
ggcggaacgc cccgtgcggt gcctggcagg gtggtcgcgc tcggccaaac cgtgcaggcg 2040
tcggattcgc tgaccggtgc cgaagagaca ttgaacgggt tgatccagtt cgatgccgcg 2100
atccagcccg gtgatgcggg cgggcccgtc gtcaacggcc taggacaggt ggtcggtatg 2160
aacacggccg cgtcctag                                               2178

<210> 10
<211> 725
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence encoding M72 fusion protein
      from TB

<400> 10
Met His His Thr Ala Ala Ser Asp Asn Phe Gln Leu Ser Gln Gly Gly
 1               5                  10                  15      
Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala Ile Ala Gly Gln
            20                  25                  30          
Ile Arg Ser Gly Gly Gly Ser Pro Thr Val His Ile Gly Pro Thr Ala
        35                  40                  45              
Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val
    50                  55                  60                  
Gln Arg Val Val Gly Ser Ala Pro Ala Ala Ser Leu Gly Ile Ser Thr
65                  70                  75                  80  
Gly Asp Val Ile Thr Ala Val Asp Gly Ala Pro Ile Asn Ser Ala Thr
                85                  90                  95      
Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser
            100                 105                 110         
Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr
        115                 120                 125             
Leu Ala Glu Gly Pro Pro Ala Glu Phe Met Val Asp Phe Gly Ala Leu
    130                 135                 140                 
Pro Pro Glu Ile Asn Ser Ala Arg Met Tyr Ala Gly Pro Gly Ser Ala
145                 150                 155                 160 
Ser Leu Val Ala Ala Ala Gln Met Trp Asp Ser Val Ala Ser Asp Leu
                165                 170                 175     
Phe Ser Ala Ala Ser Ala Phe Gln Ser Val Val Trp Gly Leu Thr Val
            180                 185                 190         
Gly Ser Trp Ile Gly Ser Ser Ala Gly Leu Met Val Ala Ala Ala Ser
        195                 200                 205             
Pro Tyr Val Ala Trp Met Ser Val Thr Ala Gly Gln Ala Glu Leu Thr
    210                 215                 220                 
Ala Ala Gln Val Arg Val Ala Ala Ala Ala Tyr Glu Thr Ala Tyr Gly
225                 230                 235                 240 
Leu Thr Val Pro Pro Pro Val Ile Ala Glu Asn Arg Ala Glu Leu Met
                245                 250                 255     
Ile Leu Ile Ala Thr Asn Leu Leu Gly Gln Asn Thr Pro Ala Ile Ala
            260                 265                 270         
Val Asn Glu Ala Glu Tyr Gly Glu Met Trp Ala Gln Asp Ala Ala Ala
        275                 280                 285             
Met Phe Gly Tyr Ala Ala Ala Thr Ala Thr Ala Thr Ala Thr Leu Leu
    290                 295                 300                 
Pro Phe Glu Glu Ala Pro Glu Met Thr Ser Ala Gly Gly Leu Leu Glu
305                 310                 315                 320 
Gln Ala Ala Ala Val Glu Glu Ala Ser Asp Thr Ala Ala Ala Asn Gln
                325                 330                 335     
Leu Met Asn Asn Val Pro Gln Ala Leu Gln Gln Leu Ala Gln Pro Thr
            340                 345                 350         
Gln Gly Thr Thr Pro Ser Ser Lys Leu Gly Gly Leu Trp Lys Thr Val
        355                 360                 365             
Ser Pro His Arg Ser Pro Ile Ser Asn Met Val Ser Met Ala Asn Asn
    370                 375                 380                 
His Met Ser Met Thr Asn Ser Gly Val Ser Met Thr Asn Thr Leu Ser
385                 390                 395                 400 
Ser Met Leu Lys Gly Phe Ala Pro Ala Ala Ala Ala Gln Ala Val Gln
                405                 410                 415     
Thr Ala Ala Gln Asn Gly Val Arg Ala Met Ser Ser Leu Gly Ser Ser
            420                 425                 430         
Leu Gly Ser Ser Gly Leu Gly Gly Gly Val Ala Ala Asn Leu Gly Arg
        435                 440                 445             
Ala Ala Ser Val Gly Ser Leu Ser Val Pro Gln Ala Trp Ala Ala Ala
    450                 455                 460                 
Asn Gln Ala Val Thr Pro Ala Ala Arg Ala Leu Pro Leu Thr Ser Leu
465                 470                 475                 480 
Thr Ser Ala Ala Glu Arg Gly Pro Gly Gln Met Leu Gly Gly Leu Pro
                485                 490                 495     
Val Gly Gln Met Gly Ala Arg Ala Gly Gly Gly Leu Ser Gly Val Leu
            500                 505                 510         
Arg Val Pro Pro Arg Pro Tyr Val Met Pro His Ser Pro Ala Ala Gly
        515                 520                 525             
Asp Ile Ala Pro Pro Ala Leu Ser Gln Asp Arg Phe Ala Asp Phe Pro
    530                 535                 540                 
Ala Leu Pro Leu Asp Pro Ser Ala Met Val Ala Gln Val Gly Pro Gln
545                 550                 555                 560 
Val Val Asn Ile Asn Thr Lys Leu Gly Tyr Asn Asn Ala Val Gly Ala
                565                 570                 575     
Gly Thr Gly Ile Val Ile Asp Pro Asn Gly Val Val Leu Thr Asn Asn
            580                 585                 590         
His Val Ile Ala Gly Ala Thr Asp Ile Asn Ala Phe Ser Val Gly Ser
        595                 600                 605             
Gly Gln Thr Tyr Gly Val Asp Val Val Gly Tyr Asp Arg Thr Gln Asp
    610                 615                 620                 
Val Ala Val Leu Gln Leu Arg Gly Ala Gly Gly Leu Pro Ser Ala Ala
625                 630                 635                 640 
Ile Gly Gly Gly Val Ala Val Gly Glu Pro Val Val Ala Met Gly Asn
                645                 650                 655     
Ser Gly Gly Gln Gly Gly Thr Pro Arg Ala Val Pro Gly Arg Val Val
            660                 665                 670         
Ala Leu Gly Gln Thr Val Gln Ala Ser Asp Ser Leu Thr Gly Ala Glu
        675                 680                 685             
Glu Thr Leu Asn Gly Leu Ile Gln Phe Asp Ala Ala Ile Gln Pro Gly
    690                 695                 700                 
Asp Ala Gly Gly Pro Val Val Asn Gly Leu Gly Gln Val Val Gly Met
705                 710                 715                 720 
Asn Thr Ala Ala Ser
                725 


<210> 11
<211> 1149
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence encoding CS protein-derived antigen
      from P. falciparum

<400> 11
atgatgagaa aacttgccat cctcagcgtc agctctttcc tgttcgtgga ggccctcttc 60
caggagtatc agtgctacgg aagcagcagc aatacaaggg tcctgaacga gctcaactat 120
gacaacgctg gaacgaacct gtataacgag ctggagatga actactatgg caagcaggag 180
aactggtata gcctgaagaa gaacagccgg tccctgggcg agaacgacga cggcaacaac 240
aacaacggcg acaacggcag ggagggcaaa gatgaggaca agagggacgg gaacaacgag 300
gataacgaga agctgcggaa gcccaagcac aagaaactca agcagcccgc cgacgggaac 360
ccggacccca atgcaaatcc caacgtcgac ccaaacgcaa accctaacgt ggaccccaac 420
gccaatccca acgtcgatcc taatgccaat ccaaatgcca accctaacgc aaatcctaat 480
gcaaacccca acgccaatcc taacgccaac ccaaatgcca acccaaacgc taaccccaac 540
gctaacccaa atgcaaatcc caatgctaac ccaaacgtgg accctaacgc taaccccaac 600
gcaaacccta acgccaatcc taacgcaaac cccaatgcaa acccaaacgc aaatcccaac 660
gctaacccta acgcaaaccc caacgccaac cctaatgcca accccaatgc taaccccaac 720
gccaatccaa acgcaaatcc aaacgccaac ccaaatgcaa accccaacgc taatcccaac 780
gccaacccaa acgccaatcc taacaagaac aatcagggca acgggcaggg ccataacatg 840
ccgaacgacc ctaatcggaa tgtggacgag aacgccaacg ccaacagcgc cgtgaagaac 900
aacaacaacg aggagccctc cgacaagcac atcaaggaat acctgaacaa gatccagaac 960
agtctgagca ccgagtggtc cccctgctcc gtgacctgcg gcaacggcat ccaggtgagg 1020
atcaagcccg gctccgccaa caagcccaag gacgagctgg actacgccaa cgacatcgag 1080
aagaagatct gcaagatgga gaaatgcagc tctgtgttca acgtcgtgaa ctccgccatc 1140
ggcctgtga                                                         1149

<210> 12
<211> 382
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence encoding CS protein-derived
      antigen from P. falciparum

<400> 12
Met Met Arg Lys Leu Ala Ile Leu Ser Val Ser Ser Phe Leu Phe Val
 1               5                  10                  15      
Glu Ala Leu Phe Gln Glu Tyr Gln Cys Tyr Gly Ser Ser Ser Asn Thr
            20                  25                  30          
Arg Val Leu Asn Glu Leu Asn Tyr Asp Asn Ala Gly Thr Asn Leu Tyr
        35                  40                  45              
Asn Glu Leu Glu Met Asn Tyr Tyr Gly Lys Gln Glu Asn Trp Tyr Ser
    50                  55                  60                  
Leu Lys Lys Asn Ser Arg Ser Leu Gly Glu Asn Asp Asp Gly Asn Asn
65                  70                  75                  80  
Asn Asn Gly Asp Asn Gly Arg Glu Gly Lys Asp Glu Asp Lys Arg Asp
                85                  90                  95      
Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys Lys
            100                 105                 110         
Leu Lys Gln Pro Ala Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro Asn
        115                 120                 125             
Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn
    130                 135                 140                 
Val Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn
145                 150                 155                 160 
Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn
                165                 170                 175     
Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn
            180                 185                 190         
Val Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn
        195                 200                 205             
Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn
    210                 215                 220                 
Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn
225                 230                 235                 240 
Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn
                245                 250                 255     
Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Lys Asn Asn Gln
            260                 265                 270         
Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp Pro Asn Arg Asn Val
        275                 280                 285             
Asp Glu Asn Ala Asn Ala Asn Ser Ala Val Lys Asn Asn Asn Asn Glu
    290                 295                 300                 
Glu Pro Ser Asp Lys His Ile Lys Glu Tyr Leu Asn Lys Ile Gln Asn
305                 310                 315                 320 
Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly
                325                 330                 335     
Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu
            340                 345                 350         
Leu Asp Tyr Ala Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys
        355                 360                 365             
Cys Ser Ser Val Phe Asn Val Val Asn Ser Ala Ile Gly Leu
    370                 375                 380         


<210> 13
<211> 1275
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence encoding CS protein-derived fusion
      protein "RTS" from P. falciparum

<400> 13
atgatggctc ccgatcctaa tgcaaatcca aatgcaaacc caaacgcaaa ccccaatgca 60
aatcctaatg caaaccccaa tgcaaatcct aatgcaaatc ctaatgccaa tccaaatgca 120
aatccaaatg caaacccaaa cgcaaacccc aatgcaaatc ctaatgccaa tccaaatgca 180
aatccaaatg caaacccaaa tgcaaaccca aatgcaaacc ccaatgcaaa tcctaataaa 240
aacaatcaag gtaatggaca aggtcacaat atgccaaatg acccaaaccg aaatgtagat 300
gaaaatgcta atgccaacag tgctgtaaaa aataataata acgaagaacc aagtgataag 360
cacataaaag aatatttaaa caaaatacaa aattctcttt caactgaatg gtccccatgt 420
agtgtaactt gtggaaatgg tattcaagtt agaataaagc ctggctctgc taataaacct 480
aaagacgaat tagattatgc aaatgatatt gaaaaaaaaa tttgtaaaat ggaaaaatgt 540
tccagtgtgt ttaatgtcgt aaatagttca ataggattag ggcctgtgac gaacatggag 600
aacatcacat caggattcct aggacccctg ctcgtgttac aggcggggtt tttcttgttg 660
acaagaatcc tcacaatacc gcagagtcta gactcgtggt ggacttctct caattttcta 720
gggggatcac ccgtgtgtct tggccaaaat tcgcagtccc caacctccaa tcactcacca 780
acctcctgtc ctccaatttg tcctggttat cgctggatgt gtctgcggcg ttttatcata 840
ttcctcttca tcctgctgct atgcctcatc ttcttattgg ttcttctgga ttatcaaggt 900
atgttgcccg tttgtcctct aattccagga tcaacaacaa ccaatacggg accatgcaaa 960
acctgcacga ctcctgctca aggcaactct atgtttccct catgttgctg tacaaaacct 1020
acggatggaa attgcacctg tattcccatc ccatcgtcct gggctttcgc aaaataccta 1080
tgggagtggg cctcagtccg tttctcttgg ctcagtttac tagtgccatt tgttcagtgg 1140
ttcgtagggc tttcccccac tgtttggctt tcagctatat ggatgatgtg gtattggggg 1200
ccaagtctgt acagcatcgt gagtcccttt ataccgctgt taccaatttt cttttgtctc 1260
tgggtataca tttaa                                                  1275

<210> 14
<211> 424
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence encoding CS protein-derived
      fusion protein "RTS" from P. falciparum

<400> 14
Met Met Ala Pro Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala
 1               5                  10                  15      
Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala
            20                  25                  30          
Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala
        35                  40                  45              
Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala
    50                  55                  60                  
Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Lys
65                  70                  75                  80  
Asn Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp Pro Asn
                85                  90                  95      
Arg Asn Val Asp Glu Asn Ala Asn Ala Asn Ser Ala Val Lys Asn Asn
            100                 105                 110         
Asn Asn Glu Glu Pro Ser Asp Lys His Ile Lys Glu Tyr Leu Asn Lys
        115                 120                 125             
Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys
    130                 135                 140                 
Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro
145                 150                 155                 160 
Lys Asp Glu Leu Asp Tyr Ala Asn Asp Ile Glu Lys Lys Ile Cys Lys
                165                 170                 175     
Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser Ile Gly
            180                 185                 190         
Leu Gly Pro Val Thr Asn Met Glu Asn Ile Thr Ser Gly Phe Leu Gly
        195                 200                 205             
Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu
    210                 215                 220                 
Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu
225                 230                 235                 240 
Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser
                245                 250                 255     
Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp
            260                 265                 270         
Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys
        275                 280                 285             
Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val
    290                 295                 300                 
Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Asn Thr Gly Pro Cys Lys
305                 310                 315                 320 
Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys
                325                 330                 335     
Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser
            340                 345                 350         
Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe
        355                 360                 365             
Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu
    370                 375                 380                 
Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly
385                 390                 395                 400 
Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile
                405                 410                 415     
Phe Phe Cys Leu Trp Val Tyr Ile
            420                 


<210> 15
<211> 3411
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence encoding HIV antigens p24-RT-Nef-p17

<400> 15
atggtcattg ttcagaacat acagggccaa atggtccacc aggcaattag tccgcgaact 60
cttaatgcat gggtgaaggt cgtggaggaa aaggcattct ccccggaggt cattccgatg 120
ttttctgcgc tatctgaggg cgcaacgccg caagacctta ataccatgct taacacggta 180
ggcgggcacc aagccgctat gcaaatgcta aaagagacta taaacgaaga ggccgccgaa 240
tgggatcgag tgcacccggt gcacgccggc ccaattgcac caggccagat gcgcgagccg 300
cgcgggtctg atattgcagg aactacgtct acccttcagg agcagattgg gtggatgact 360
aacaatccac caatcccggt cggagagatc tataagaggt ggatcatact gggactaaac 420
aagatagtcc gcatgtattc tccgacttct atactggata tacgccaagg cccaaaggag 480
ccgttcaggg actatgtcga ccgattctat aagacccttc gcgcagagca ggcatcccag 540
gaggtcaaaa attggatgac agaaactctt ttggtgcaga atgcgaatcc ggattgtaaa 600
acaattttaa aggctctagg accggccgca acgctagaag agatgatgac ggcttgtcag 660
ggagtcggtg gaccggggca taaagcccgc gtcttacaca tgggcccgat atctccgata 720
gaaacagttt cggtcaagct taaaccaggg atggatggtc caaaggtcaa gcagtggccg 780
ctaacggaag agaagattaa ggcgctcgta gagatttgta ctgaaatgga gaaggaaggc 840
aagataagca agatcgggcc agagaacccg tacaatacac cggtatttgc aataaagaaa 900
aaggattcaa caaaatggcg aaagcttgta gattttaggg aactaaacaa gcgaacccaa 960
gacttttggg aagtccaact agggatccca catccagccg gtctaaagaa gaagaaatcg 1020
gtcacagtcc tggatgtagg agacgcatat tttagtgtac cgcttgatga ggacttccga 1080
aagtatactg cgtttactat accgagcata aacaatgaaa cgccaggcat tcgctatcag 1140
tacaacgtgc tcccgcaggg ctggaagggg tctccggcga tatttcagag ctgtatgaca 1200
aaaatacttg aaccattccg aaagcagaat ccggatattg taatttacca atacatggac 1260
gatctctatg tgggctcgga tctagaaatt gggcagcatc gcactaagat tgaggaactg 1320
aggcaacatc tgcttcgatg gggcctcact actcccgaca agaagcacca gaaggagccg 1380
ccgttcctaa agatgggcta cgagcttcat ccggacaagt ggacagtaca gccgatagtg 1440
ctgcccgaaa aggattcttg gaccgtaaat gatattcaga aactagtcgg caagcttaac 1500
tgggcctctc agatttaccc aggcattaag gtccgacagc tttgcaagct actgagggga 1560
actaaggctc taacagaggt catcccatta acggaggaag cagagcttga gctggcagag 1620
aatcgcgaaa ttcttaagga gccggtgcac ggggtatact acgacccctc caaggacctt 1680
atagccgaga tccagaagca ggggcagggc caatggacgt accagatata tcaagaaccg 1740
tttaagaatc tgaagactgg gaagtacgcg cgcatgcgag gggctcatac taatgatgta 1800
aagcaactta cggaagcagt acaaaagatt actactgagt ctattgtgat atggggcaag 1860
accccaaagt tcaagctgcc catacagaag gaaacatggg aaacatggtg gactgaatat 1920
tggcaagcta cctggattcc agaatgggaa tttgtcaaca cgccgccact tgttaagctt 1980
tggtaccagc ttgaaaagga gccgatagta ggggcagaga ccttctatgt cgatggcgcc 2040
gcgaatcgcg aaacgaagct aggcaaggcg ggatacgtga ctaatagggg ccgccaaaag 2100
gtcgtaaccc ttacggatac caccaatcag aagactgaac tacaagcgat ttaccttgca 2160
cttcaggata gtggcctaga ggtcaacata gtcacggact ctcaatatgc gcttggcatt 2220
attcaagcgc agccagatca aagcgaaagc gagcttgtaa accaaataat agaacagctt 2280
ataaagaaag agaaggtata tctggcctgg gtccccgctc acaagggaat tggcggcaat 2340
gagcaagtgg acaagctagt cagcgctggg attcgcaagg ttcttgcgat ggggggtaag 2400
tggtctaagt ctagcgtagt cggctggccg acagtccgcg agcgcatgcg acgcgccgaa 2460
ccagccgcag atggcgtggg ggcagcgtct agggatctgg agaagcacgg ggctataact 2520
tccagtaaca cggcggcgac gaacgccgca tgcgcatggt tagaagccca agaagaggaa 2580
gaagtagggt ttccggtaac tccccaggtg ccgttaaggc cgatgaccta taaggcagcg 2640
gtggatcttt ctcacttcct taaggagaaa ggggggctgg agggcttaat tcacagccag 2700
aggcgacagg atattcttga tctgtggatt taccataccc aggggtactt tccggactgg 2760
cagaattaca ccccggggcc aggcgtgcgc tatcccctga ctttcgggtg gtgctacaaa 2820
ctagtcccag tggaacccga caaggtcgaa gaggctaata agggcgagaa cacttctctt 2880
cttcacccgg taagcctgca cgggatggat gacccagaac gagaggttct agaatggagg 2940
ttcgactctc gacttgcgtt ccatcacgta gcacgcgagc tgcatccaga atatttcaag 3000
aactgccgcc caatgggcgc cagggccagt gtacttagtg gcggagaact agatcgatgg 3060
gaaaagatac gcctacgccc ggggggcaag aagaagtaca agcttaagca cattgtgtgg 3120
gcctctcgcg aacttgagcg attcgcagtg aatccaggcc tgcttgagac gagtgaaggc 3180
tgtaggcaaa ttctggggca gctacagccg agcctacaga ctggcagcga ggagcttcgt 3240
agtctttata ataccgtcgc gactctctac tgcgttcatc aacgaattga aataaaggat 3300
actaaagagg cccttgataa aattgaggag gaacagaata agtcgaaaaa gaaggcccag 3360
caggccgccg ccgacaccgg gcacagcaac caggtgtccc aaaactacta a          3411

<210> 16
<211> 1136
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence encoding HIV antigens
      p24-RT-Nef-p17

<400> 16
Met Val Ile Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile
 1               5                  10                  15      
Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala
            20                  25                  30          
Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala
        35                  40                  45              
Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln
    50                  55                  60                  
Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu
65                  70                  75                  80  
Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln
                85                  90                  95      
Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu
            100                 105                 110         
Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly
        115                 120                 125             
Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg
    130                 135                 140                 
Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu
145                 150                 155                 160 
Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu
                165                 170                 175     
Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val
            180                 185                 190         
Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro
        195                 200                 205             
Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly
    210                 215                 220                 
Pro Gly His Lys Ala Arg Val Leu His Met Gly Pro Ile Ser Pro Ile
225                 230                 235                 240 
Glu Thr Val Ser Val Lys Leu Lys Pro Gly Met Asp Gly Pro Lys Val
                245                 250                 255     
Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val Glu Ile
            260                 265                 270         
Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly Pro Glu
        275                 280                 285             
Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr
    290                 295                 300                 
Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln
305                 310                 315                 320 
Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys
                325                 330                 335     
Lys Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser
            340                 345                 350         
Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro
        355                 360                 365             
Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu
    370                 375                 380                 
Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Cys Met Thr
385                 390                 395                 400 
Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val Ile Tyr
                405                 410                 415     
Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln
            420                 425                 430         
His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg Trp Gly
        435                 440                 445             
Leu Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Lys
    450                 455                 460                 
Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile Val
465                 470                 475                 480 
Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val
                485                 490                 495     
Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg
            500                 505                 510         
Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu Val Ile
        515                 520                 525             
Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile
    530                 535                 540                 
Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu
545                 550                 555                 560 
Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile
                565                 570                 575     
Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Arg Met
            580                 585                 590         
Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln
        595                 600                 605             
Lys Ile Thr Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe
    610                 615                 620                 
Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Thr Trp Trp Thr Glu Tyr
625                 630                 635                 640 
Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro
                645                 650                 655     
Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val Gly Ala
            660                 665                 670         
Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly
        675                 680                 685             
Lys Ala Gly Tyr Val Thr Asn Arg Gly Arg Gln Lys Val Val Thr Leu
    690                 695                 700                 
Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln Ala Ile Tyr Leu Ala
705                 710                 715                 720 
Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser Gln Tyr
                725                 730                 735     
Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Gln Ser Glu Ser Glu Leu
            740                 745                 750         
Val Asn Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu Lys Val Tyr Leu
        755                 760                 765             
Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly Asn Glu Gln Val Asp
    770                 775                 780                 
Lys Leu Val Ser Ala Gly Ile Arg Lys Val Leu Ala Met Gly Gly Lys
785                 790                 795                 800 
Trp Ser Lys Ser Ser Val Val Gly Trp Pro Thr Val Arg Glu Arg Met
                805                 810                 815     
Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala Ala Ser Arg Asp
            820                 825                 830         
Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala Ala Thr Asn
        835                 840                 845             
Ala Ala Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly Phe
    850                 855                 860                 
Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr Tyr Lys Ala Ala
865                 870                 875                 880 
Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu Gly Leu
                885                 890                 895     
Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu Trp Ile Tyr His
            900                 905                 910         
Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro Gly
        915                 920                 925             
Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys Leu Val Pro Val
    930                 935                 940                 
Glu Pro Asp Lys Val Glu Glu Ala Asn Lys Gly Glu Asn Thr Ser Leu
945                 950                 955                 960 
Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro Glu Arg Glu Val
                965                 970                 975     
Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His His Val Ala Arg
            980                 985                 990         
Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Arg Pro Met Gly Ala Arg
        995                 1000                1005            
Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile Arg
    1010                1015                1020                
Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Trp
1025                1030                1035                1040
Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu
                1045                1050                1055    
Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu
            1060                1065                1070        
Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala Thr
        1075                1080                1085            
Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala
    1090                1095                1100                
Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln
1105                1110                1115                1120
Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr
                1125                1130                1135    

