                         SEQUENCE LISTING

<110>  Symphogen A/S
       Pedersen, Mikkel W
       Kragh, Michael
       Hey, Adam S
       Jacobsen, Helle
 
<120>  RECOMBINANT ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY 
       COMPOSITIONS

<130>  P122PC00

<160>  141   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  1
gacsgatggg cccttggtgg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  2
gctgtaggtg ctgtctttgc                                                   20


<210>  3
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  3
tattcccatg gcgcgccsag gtccarctgc arcagyctg                              39


<210>  4
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  4
tattcccatg gcgcgccgar gtgmagctkg tkgagtc                                37


<210>  5
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  5
tattcccatg gcgcgccsag gtgcagctkm aggagtc                                37


<210>  6
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  6
tattcccatg gcgcgcccag gttactctga aagagtc                                37


<210>  7
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  7
tattcccatg gcgcgcccag atccagttgg tgcagtctg                              39


<210>  8
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  8
ggcgcgccat gggaatagct agccgayatc cagatgachc arwct                       45


<210>  9
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  9
ggcgcgccat gggaatagct agccracatt gtgmtgachc agtc                        44


<210>  10
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  10
ggcgcgccat gggaatagct agccsamatt gtkctsaccc artctc                      46


<210>  11
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  11
ggcgcgccat gggaatagct agccgatrtt gtgatgacbc arrct                       45


<210>  12
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  12
ggaggcgctc gagacggtga ccgtggtccc                                        30


<210>  13
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  13
ggaggcgctc gagactgtga gagtggtgcc                                        30


<210>  14
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  14
ggaggcgctc gagacagtga ccagagtccc                                        30


<210>  15
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  15
ggaggcgctc gagacggtga ctgaggttcc                                        30


<210>  16
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  16
ggacagggmt ccakagttcc adkt                                              24


<210>  17
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  17
gacagatggt gcagccacag ttcgtttgat ttccagcttg gtg                         43


<210>  18
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  18
gacagatggt gcagccacag ttcgttttat ttccagcttg gtc                         43


<210>  19
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  19
gacagatggt gcagccacag ttcgttttat ttccaacttt gtc                         43


<210>  20
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  20
gacagatggt gcagccacag ttcgtttcag ctccagcttg gtc                         43


<210>  21
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  21
gaactgtggc tgcaccatct gtc                                               23


<210>  22
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  22
accgcctcca ccggcggccg cttattaaca ctctcccctg ttg                         43


<210>  23
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  23
accgcctcca ccggcggccg cttattaaca ctctcccctg ttgaagctct t                51


<210>  24
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  24
cgcgccgagg tccaactgca gcaacctggg tctgagctgg tgaggcctgg agcttcagtg       60

aagctgtcct gcaaggcttc tggctacaca ttcaccagct actggatgca ctgggtgaag      120

cagaggcctg gacaaggcct tgagtggatt gggaatattt atcctggtag tcgtagtact      180

aactacgatg agaagttcaa gagcaaggcc acactgactg tagacacatc ctccagcaca      240

gcctacatgc agctcagcag cctgacatct gaggactctg cggtctatta ctgtacaaga      300

aatggggatt actacgttag tagcggggat gctatggact actggggtca aggaacctca      360

gtcaccgtct cg                                                          372


<210>  25
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  25
cgcgcccagg tccaactgca gcagcctggg gctgaactgg tggagcctgg gggttcagtg       60

aagctgtcct gcaaggcttc tggctacacc ttcaccagtc actggatgca ctgggtgaag      120

cagaggcctg gacaaggcct tgagtggata ggtgagatta atcctagcag cggtcgtaat      180

aactacaatg agaagttcaa gagtaaggcc acactgactg tagacaaatc ctccagcaca      240

gcctacatgc aattcagcag cctgacatct gaggactctg cggtctatta ttgtgtaaga      300

tactatggtt acgacgaagc tatggactac tggggtcaag gaacctcagt caccgtctcg      360


<210>  26
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  26
cgcgccgaag tgcagctggt ggagtctggg ggaggcttag tgaagcctgg agggtccctg       60

aaactctcct gtgcagcctc tggattcact ttcagtagtt atgccctgtc ttgggttcgc      120

cagactccag agaggaggct ggagtgggtc gcatccatta gtggtgttgg tagcacctac      180

tttccagaca gtgtgaaggg ccgtttcacc atgtccagag ataatgccag gaacatcctg      240

tacctccaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagaggt      300

tctgatggtt acttctatgc tatggactac tggggtcaag gaacctcagt caccgtctcg      360


<210>  27
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  27
cgcgcccagg tgcagcttca gcagcctggg gctgaactgg tgaagcctgg ggcttcagtg       60

aagctgtcct gtaaggcttc tggctacacc ttcaccagcc actggatgca ctgggtgcag      120

cagaggcctg gacaaggcct tgagtggatt ggagagattc atcctagcaa cggtcgtact      180

aactacaatg agaagttcaa gaacaaggcc acactgactg tagacaaatc tcccagcaca      240

gcctacatgc aactcagcag tttgacatct gaggactctg cggtctatta ctgtgcaaga      300

tactatggtt acgacgatgc tatggactac tggggtcaag gaacctcagt caccgtctcg      360


<210>  28
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  28
cgcgccgaag tgcagctggt ggagtctggg ggaggcttag tgaagcctgg agggtccctg       60

aaactctcct gtgcagcctc tggattcgct ttcagtagct atgacatgtc ttgggttcgc      120

cagactccgg agaagaggct ggagtgggtc gcatacattg gtagtggtga tgataatacc      180

cactatccag actctgtgaa gggccgattc accatctcca gacacaatgc caaaaacacc      240

ctatacctgc aaatgagcag tctgaagtct gaggacacag ccatgtatta ctgtgcaaga      300

cagaagtatg gtaactacgg ggacactatg gactactggg gtcaaggaac ctcagtcacc      360

gtctcg                                                                 366


<210>  29
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  29
cgcgcccagg ttcagctgaa ggagtcagga cctggcctgg tggcgccctc acagagcctg       60

tccatcactt gctctgtctc tggtttttca ttaaccatct atggtgtaca ctgggttcgc      120

cagcctccag gaaagggtct ggagtggctg ggagttatgt gggctggtgg aaatacagat      180

tataattcgg ctctcatgtc cagactgaac atcagcaagg acaattccaa gagccaagtt      240

ttcttaaaag tgaacagtct acaaactgat gacacagcca tgtactattg taccagagat      300

cccgatggtt actacgtggg gtggttcttc gatgtctggg gcgcggggac cacggtcacc      360

gtctcg                                                                 366


<210>  30
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  30
cgcgccgaag tgcagctggt ggagtctggg ggaggcttag tgaagcctgg agggtccctg       60

aaactctcct gtgcagcctc tggattcgct tacagtacct atgacatgtc ttgggttcgc      120

cagactccgg agaagaggct ggagtgggtc gcatacatta gtagtggtgg tgatgccgcc      180

tactatcccg acactgtgaa gggccgattc accatctcca gagacaatgc caaaaacacc      240

ctatacctgc aaatgagcag tctgaagtct gaggacacag ccatgtatta ctgtgcgagg      300

tctcgctatg gaaactacgg ggacgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtctcg                                                                 366


<210>  31
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  31
cgcgccgagg tccagctgca acagtctgga cctgagctgg tgaaacctgg ggcttcagtg       60

aagataccct gcaagacttc tggatacact ttcactgact acaacatggc ctgggtgaag      120

cagagccatg gaaagagcct tgagtggatt ggagatatta ttcctaacaa tggtggtgct      180

atctacaacc agaaattcaa gggcaaggcc actttgactg tagacaaatc ctccagtaca      240

gcctccatgg agctccgcag cctgacatct gaggacactg cagtctattt ctgtgcaaga      300

aagaatatct actataggta cgacggggca ggtgctctgg actactgggg tcaaggaacc      360

tcagtcaccg tctcg                                                       375


<210>  32
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  32
cgcgcccagg tgcagctgaa ggagtcagga cctggcctgg tggcgccctc acagagcctg       60

tccatcactt gcactgtctc tgggttttca ttaaccacct atggggtaca ctgggttcgc      120

cagcctccag gaaagggtct ggagtggctg ggagtaatat gggctggtgg aagcacaaat      180

tataattcgg ctctcatgtc cagactgagc atcaagaaag acaactccaa gagccaagtt      240

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tgtactactg tgccagagcc      300

tatggttaca actttgacta ttggggccaa ggcaccactc tcacagtctc g               351


<210>  33
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  33
cgcgccgaag tgcagctggt ggagtctggg ggaggcttag tgaagcctgg agggtccctg       60

aaactctcct gtgcagtctc tggattcact ttcagtagct atgtcatgtc ttgggttcgc      120

cagactccgg agaagaggct ggagtgggtc gcaaccatta ctagtggtgg taggaacatc      180

tactatctag acagtgtgaa ggggcgattc actatctcca gagacaatgc caagaacacc      240

ctgtacctgc aaatgagcag tctgaggtct gaggacacgg ccatgtatta ctgtgcaaga      300

catgaggact ataggtacga cggttactat gctatggact actggggtca aggaacctca      360

gtcaccgtct cg                                                          372


<210>  34
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  34
cgcgccgaag tgcagctggt ggagtctggg ggaggcttag tgaagcctgg agagtccttg       60

aaactctcct gtgcagcctc tggattcgct ttcagttact ctgacatgtc ttgggttcgc      120

cagactccgg agaagaggct ggagtgggtc gcatacatga gtagtgctgg tgatgtcacc      180

ttctattcag acactgtgaa gggccgattc accatctcca gagacaatgc caagaacacc      240

ctgtatctgc aagtgagcag tctgaagtct gaggacacag ccatatatta ctgtgtaaga      300

caccgggacg tggctatgga ctactggggt caaggaacct cagtcaccgt ctcg            354


<210>  35
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  35
cgcgcccagg tccaactgca gcagcctggg gctgaactgg tgaagcctgg ggcttcagtg       60

aagctgtcct gcaaggcttc tggctacacc ttcaccagcg actggatgca ctggatgaaa      120

cagaggcctg gacaaggcct tgagtggatt ggagagatta atcctagtaa cggtcgctct      180

agctacaatg agaagttcaa gagcaaggcc acactgactg tagacaaatc ctccagcaca      240

gcctacatgc aactcagcag cctgacatct gaggactctg cggtctatta ctgtgcaaga      300

ataggtggta tctacgtgga gacttactgg ggccaaggga ctctggtcac tgtctcg         357


<210>  36
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  36
cgcgccgagg tccagcttca gcagtctgga gctgagctgg tgaggcctgg gtcctcagtg       60

aagatttcct gcaaggcttc tggctatgca ttcagtagct actggatgaa ctgggtgagg      120

cagaggcctg gacagggtct tgagtggatt ggacagattt atcctggaga tggtgatact      180

aactacaatg gaaagttcaa gggtagagcc acactgactg caaacaaatc ctccagcaca      240

gcctacatgc agctcagcag cctaacatct gaggactctg cggtctattt ctgtgcaaga      300

agggcatctt ccctctatga tgtttacccc tactactttg actactgggg ccaaggcacc      360

actctcacag tctcg                                                       375


<210>  37
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  37
cgcgcccagg tccaactgca gcagcctggg gctgaactgg tgaagcctgg ggcttcaatg       60

aagctgtcct gcaaggcttc tggctacacc ttcaccaact actggatgca ctgggtgaag      120

cagaggcctg gacaaggcct tgaatggatt ggagaaatta atcctagcaa cggtcgtact      180

aattacaatg agaagttcaa gagcaaggcc acactgactg tagacaaatc gtccagcaca      240

gcctacatgc aactcagcag cctgacatct gaggactctg gggtctatta ctgtgcaaaa      300

ggggggaact actatgatta cgactgggac tactggggcc aaggcaccac tctcacagtc      360

tcg                                                                    363


<210>  38
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  38
cgcgcccagg tgcagctgaa ggagtcagga cctggcctgg tggcgccctc acagagcctg       60

tccatcactt gcactgtctc tgggttttca ttaaccatct atggtgtaca ctgggttcgc      120

cagcctccag gaaagggtct ggagtggctg ggagtaatat gggctggtgg aaacacaaat      180

tataattcgg ctctcatgtc cagactgagc atcagcaaag acaactccaa gagtcaagtt      240

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tgtacttctg tgccagaggc      300

tatggctaca atttagacta ttggggccaa ggcaccactc tcacagtctc g               351


<210>  39
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  39
cgcgcccagg tgcagctgaa ggagtcagga cctggcctgg tggcgccctc acagagcctg       60

tccatcacat gcaccgtctc aggattctca ttaaccggcc atggtgtaaa ctgggttcgc      120

cagcctccag gaaagggtct ggagtggctg ggaatgatat ggggtgatgg aagcacggac      180

tataattcaa ctctcaaatc cagactgagt atcagcaagg acaactccaa gagccaagtt      240

ttcttaaaaa tgaacagtct gcagactgat gacaccgcca ggtactactg tgccagaggc      300

tacggctacc tttactactt tgactactgg ggccaaggca ccactctcac agtctcg         357


<210>  40
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  40

Arg Ala Glu Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Pro Gly Ser Arg Ser Thr Asn Tyr Asp Glu 
    50                  55                  60                  


Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asn Gly Asp Tyr Tyr Val Ser Ser Gly Asp Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        115                 120                 


<210>  41
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  41

Arg Ala Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Glu Pro 
1               5                   10                  15      


Gly Gly Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser His Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Asn Pro Ser Ser Gly Arg Asn Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Tyr Tyr Gly Tyr Asp Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser 
        115                 120 


<210>  42
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Leu Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu 
        35                  40                  45              


Trp Val Ala Ser Ile Ser Gly Val Gly Ser Thr Tyr Phe Pro Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Arg Asn Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ser Asp Gly Tyr Phe Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser 
        115                 120 


<210>  43
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  43

Arg Ala Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser His Trp Met His Trp Val Gln Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile His Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Pro Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Tyr Tyr Gly Tyr Asp Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser 
        115                 120 


<210>  44
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30          


Ser Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu 
        35                  40                  45              


Trp Val Ala Tyr Ile Gly Ser Gly Asp Asp Asn Thr His Tyr Pro Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gln Lys Tyr Gly Asn Tyr Gly Asp Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        115                 120         


<210>  45
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  45

Arg Ala Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 
1               5                   10                  15      


Ser Gln Ser Leu Ser Ile Thr Cys Ser Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30          


Ile Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Val Met Trp Ala Gly Gly Asn Thr Asp Tyr Asn Ser Ala 
    50                  55                  60                  


Leu Met Ser Arg Leu Asn Ile Ser Lys Asp Asn Ser Lys Ser Gln Val 
65                  70                  75                  80  


Phe Leu Lys Val Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Asp Pro Asp Gly Tyr Tyr Val Gly Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
        115                 120         


<210>  46
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  46

Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Tyr Ser 
            20                  25                  30          


Thr Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu 
        35                  40                  45              


Trp Val Ala Tyr Ile Ser Ser Gly Gly Asp Ala Ala Tyr Tyr Pro Asp 
    50                  55                  60                  


Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Arg Tyr Gly Asn Tyr Gly Asp Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        115                 120         


<210>  47
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  47

Arg Ala Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Pro Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Asp Tyr Asn Met Ala Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Asp Ile Ile Pro Asn Asn Gly Gly Ala Ile Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Ser Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Lys Asn Ile Tyr Tyr Arg Tyr Asp Gly Ala Gly Ala 
            100                 105                 110         


Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        115                 120                 125 


<210>  48
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  48

Arg Ala Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 
1               5                   10                  15      


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30          


Thr Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala 
    50                  55                  60                  


Leu Met Ser Arg Leu Ser Ile Lys Lys Asp Asn Ser Lys Ser Gln Val 
65                  70                  75                  80  


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Tyr Gly Tyr Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser 
        115         


<210>  49
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  49

Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu 
        35                  40                  45              


Trp Val Ala Thr Ile Thr Ser Gly Gly Arg Asn Ile Tyr Tyr Leu Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Glu Asp Tyr Arg Tyr Asp Gly Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        115                 120                 


<210>  50
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  50

Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Glu Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30          


Tyr Ser Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu 
        35                  40                  45              


Trp Val Ala Tyr Met Ser Ser Ala Gly Asp Val Thr Phe Tyr Ser Asp 
    50                  55                  60                  


Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asp Val Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser 
        115             


<210>  51
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  51

Arg Ala Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser Asp Trp Met His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Ser Ser Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ile Gly Gly Ile Tyr Val Glu Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  52
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Ala Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
1               5                   10                  15      


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
            20                  25                  30          


Ser Tyr Trp Met Asn Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
    50                  55                  60                  


Lys Phe Lys Gly Arg Ala Thr Leu Thr Ala Asn Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Arg Ala Ser Ser Leu Tyr Asp Val Tyr Pro Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
        115                 120                 125 


<210>  53
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  53

Arg Ala Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Asn Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Gly Gly Asn Tyr Tyr Asp Tyr Asp Trp Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser 
        115                 120     


<210>  54
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  54

Arg Ala Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 
1               5                   10                  15      


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30          


Ile Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala 
    50                  55                  60                  


Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val 
65                  70                  75                  80  


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Tyr Gly Tyr Asn Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser 
        115         


<210>  55
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  55

Arg Ala Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 
1               5                   10                  15      


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30          


Gly His Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Thr 
    50                  55                  60                  


Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val 
65                  70                  75                  80  


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Tyr Gly Tyr Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser 
        115                 


<210>  56
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  56
ctagccgaca ttcagatgac tcagactaca tcctccctgt ctgcctctct gggagacaga       60

gtcaccatca gttgcaggac aagtcaggac attggcaatt atttaaactg gtatcagcag      120

aaaccagatg gaactgttaa actcctgatc tactacacat caagattaca ctcaggagtc      180

ccatcaaggt tcagtggcag tgggtctgga acagattttt ctctcaccat taacaacgtg      240

gagcaagagg atgttgccac ttacttttgc caacactata atacggttcc tccgacgttc      300

ggtggaggca ccaagctgga aatcaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  57
<211>  663
<212>  DNA
<213>  Homo sapiens

<400>  57
ctagccgaca tcgtgatgac acaagctgca ttctccaatc cagtcactct tggaacatca       60

gcttccatct cctgcaggtc tagtaagagt ctcctacata gtaatggcat cacttatttg      120

tattggtatc tgcagaagcc aggccagtct cctcagctcc tgatttatca gatgtccaac      180

cttgcctcag gagtcccaga caggttcagt agcagtgggt caggaactga tttcacactg      240

agaatcagca gagtggaggc tgaggatgtg ggtgtttatt actgtgctca aaatctagaa      300

cttccgtaca cgttcggagg ggggaccaag ctggaaataa aacgaactgt ggctgcacca      360

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg      420

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc      480

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac      540

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc      600

tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag      660

tgt                                                                    663


<210>  58
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  58
ctagccgaca ttgtgctgac tcagtctcct gcttccttag ctgtatctct ggggcagagg       60

gccaccattt catgcagggc cagcaaaagt gtcagtacat ctggctatag ttttatgcac      120

tggtaccaac tgaaaccagg acagccaccc aaactcctca tctatcttgc atccaaccta      180

gaatctgggg tccctgccag gttcagtggc agtgggtctg ggacagactt caccctcaac      240

atccatcctg tggaagagga ggatgctgca acctattact gtcagcacag tagggagttt      300

ccgttaacgt tcggaggggg gaccaagctg gaaataaaac gaactgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  59
<211>  657
<212>  DNA
<213>  Homo sapiens

<400>  59
gatattgtga tgactcaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc       60

atctcctgca ggtctagtaa gagtctccta catagtaatg gcatcactta tttgtattgg      120

tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtagcagt gggtcaagaa ctgatttcac actgagaatc      240

agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaacttccg      300

tacacgttcg gaggggggac caagctggaa ataaaacgaa ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  60
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  60
ctagccgatg ttgtgatgac tcagactcca ctctccctgc ctgtcagtct tggagatcaa       60

gcctccatct cttgcagatc tagtcagagc cttgtacaca gtaatggaaa cacctattta      120

cattggtacc tgcagaagcc aggccagtct ccaaaactcc tgatctacaa agtttccaac      180

cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc      240

aagatcagca gagtggaggc tgaggatctg ggagtttatt tctgctctca aagtacacat      300

gttcccacgt tcggaggggg gaccaagctg gaaatcaaac gaactgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  61
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  61
ctagccgaca ttgtgatgac ccagtctcac aaattcatgt ccacatcagt gggagacagg       60

gtcagcatca cctgcaaggc cagtcaggat gtgactaatg ccgtagcctg gtatcaacaa      120

aaaccaggac aatctcctaa actactgatt tactgggcat ccatccgaca cactggagtc      180

cctgatcgct tcacaggcag tagatctggg acagattata ctctcaccat caacagtgtg      240

caggctgaag acctggccct ttattattgt cagcaacatt ataacactcc gctcacgttc      300

ggtgctggga ccaagctgga aataaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  62
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  62
ctagccgatg ttgtgatgac acagactcca ctctccctgc ctgtcagtct tggagatcaa       60

gcctccatct cttgcagatc tagtcagagc cttgtacaca gtaatggtaa cacctattta      120

cattggtacc tgcagaagcc aggccagtct ccaaagctcc tgctctacaa agtttccaac      180

cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc      240

aagatcagca gagtggagtc tgaggatctg ggagtttatt tctgctctca aaatacacat      300

gtgtacacgt tcggaggggg gacaaagttg gaaataaaac gaactgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  63
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  63
ctagcccaaa ttgtgctcac acagtctcca gcaatcatgt ctgcatctcc aggggagaag       60

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tttactggta ccagcagaag      120

ccaggatcct cccccagact cctgatttat gacgcatcca acctggcttc tggagtccct      180

gttcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag ccgaatggag      240

gctgaagatg ctgccactta ttactgccag cagtggagca gttacccaat cacgttcggc      300

tcggggacaa agttggaaat aaaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  64
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  64
ctagccgata tccagatgac tcagactaca tcctccctgt ctgcctctct gggagacaga       60

gtcaccatca gttgcagtgc aagtcagggc attaccaatt atttaaactg gtatcagcag      120

aaaccagatg gaactgttaa actcctgatc tattactcat caagtttaca ctcaggagtc      180

ccatcaaggt tcagtggcag tgggtctggg acagattatt ctctcaccat cagcaacctg      240

gaacctgaag atattgccac ttactattgt cagcagtata gtgagattcc gtacacgttc      300

ggagggggga ccaagctgga gctgaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  65
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  65
ctagcccaaa ttgtgctgac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag       60

gtcaccataa cctgcagtgc cagctcaagt gtaagttaca tgcactggtt ccagcagaag      120

ccaggcactt ctcccaaact ctggatttat agtacatcca acctggcttc tggagtccct      180

gctcgcttca gtggcagtgg atctgggacc tcttactctc tcacaatcag ccgaatggag      240

gctgaagatg ctgccactta ttactgccag caaaggagta gttacccata cacgttcgga      300

ggggggacca agctggagct gaaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  66
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  66
ctagccgatg ttgtgatgac ccagactcca ctctccctgc ctgtcagtct tggagatcaa       60

gcctccatct cttgcagatc tagtcagagc cttgtacaca gtaatggaaa cacctattta      120

cattggtacc tgcagaagcc aggccagtct ccaaagctcc tgatctacaa agtttccaac      180

cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc      240

aagatcagca gagtggaggc tgaggatctg ggagtttatt tctgctctca aagtacacat      300

gttccgacgt tcggtggagg caccaagctg gaaatcaaac gaactgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  67
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  67
ctagccgaca ttgtgctaac acagtctcct gcttccttag ctgtatctct ggggcagagg       60

gccaccatct catgcagggc cagccaaagt gtcagtacat ctacctatag ttatatgcac      120

tggtatcaac agaaatcagg acagccaccc aaactcctca tcaagtatgc atccaaccta      180

gagtctgggg tccctgccag gttcagtggc agtgggtctg ggacagactt caccctcaac      240

atccatcctg tggaggagga ggatactgca acatattact gtcagcacag ttgggagatt      300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaac gaactgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  68
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  68
ctagccgaca tccagatgac acaaactaca tcctccctgt ctgcctctct gggagacaga       60

gtcaccatca gttgcagggc aagtcaggac attagcaatt atttaaactg gtatcagcag      120

aaaccagatg gaactgttaa agtcctgatc tactacacat caagattaca ctcaggagtc      180

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg      240

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc      300

ggagggggga ccaagctgga aataaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  69
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  69
ctagccgaca ttcagatgac ccagactaca tcctccctgt ctgcctctct gggagacaga       60

gtcaccatca gttgcagtgc aagtcaggac attagcaatt atttaaactg gtatcagcag      120

aaaccagatg gaactgttaa actcctgatc tatcacacat caactttaca ctcaggagtc      180

ccatcaaggt tcagtggcag tgggtctggg acagattatt ctctcaccat cagcaacctg      240

gaacctgaag atattgccac ttactattgt cagcaatata gtaagcttcc gtggacgttc      300

ggtggaggca ccaagctgga aatcaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  70
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  70
ctagccgaca ttcagatgac acagactact tcctccctgt ctgcctctct gggagacaga       60

gtcaccatta gttgcagtgc aagtcagggc attagtaatt atttaaactg gtatcagcag      120

aaaccagatg gaactgttaa actcctgatc tattacacat caagtttaca ctcaggagtc      180

ccatcaaggt tcagtggcag tgggtctggg acagattatt ctctcaccat cagcaacctg      240

gaacctgaag atattgccac ttactattgt cagcagtata gtaagcttcc gtacacgttc      300

ggagggggga ccaagctgga aatcaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  71
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  71
ctagccgaaa atgtgctgac tcagtctcca gcaatcatgt ctgcatctcc aggggaaaag       60

gtcaccatga cctgcagggc cagctcaagt gtaagttcca gttacttgca ctggtaccag      120

caaaagtcag gtgcctcccc caaactctgg atttatagca catccaactt ggcttctgga      180

gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac agtcaacagt      240

gtggagactg aagatgctgc cacttattac tgccaccagt acagtggttt cccattcacg      300

ttcggctcgg ggaccaagct ggagctgaaa cgaactgtgg ctgcaccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  72
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile Gly 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Asn Asn Val 
65                  70                  75                  80  


Glu Gln Glu Asp Val Ala Thr Tyr Phe Cys Gln His Tyr Asn Thr Val 
                85                  90                  95      


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  73
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  73

Leu Ala Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr 
1               5                   10                  15      


Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu 
            20                  25                  30          


His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly 
        35                  40                  45              


Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220     


<210>  74
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  74

Leu Ala Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser 
            20                  25                  30          


Thr Ser Gly Tyr Ser Phe Met His Trp Tyr Gln Leu Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
65                  70                  75                  80  


Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His 
                85                  90                  95      


Ser Arg Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  75
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  75

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Arg Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  76
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  76

Leu Ala Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
1               5                   10                  15      


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
            20                  25                  30          


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
        35                  40                  45              


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
                85                  90                  95      


Gln Ser Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  77
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  77

Leu Ala Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Thr 
            20                  25                  30          


Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Thr Gly Ser Arg Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Val 
65                  70                  75                  80  


Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Asn Thr 
                85                  90                  95      


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  78
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  78

Leu Ala Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
1               5                   10                  15      


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
            20                  25                  30          


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
        35                  40                  45              


Gln Ser Pro Lys Leu Leu Leu Tyr Lys Val Ser Asn Arg Phe Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Arg Val Glu Ser Glu Asp Leu Gly Val Tyr Phe Cys Ser 
                85                  90                  95      


Gln Asn Thr His Val Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  79
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  79

Leu Ala Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
1               5                   10                  15      


Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Ile Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  80
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  80

Leu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Thr 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Ser Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Ile 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  81
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  81

Leu Ala Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
1               5                   10                  15      


Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  82
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  82

Leu Ala Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
1               5                   10                  15      


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
            20                  25                  30          


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
        35                  40                  45              


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
                85                  90                  95      


Gln Ser Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  83
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  83

Leu Ala Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Thr Ser Thr Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
65                  70                  75                  80  


Ile His Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His 
                85                  90                  95      


Ser Trp Glu Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  84
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  84

Leu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Val 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  85
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  85

Leu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp Ile Ser 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr His Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu 
                85                  90                  95      


Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  86
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  86

Leu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  87
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  87

Leu Ala Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
1               5                   10                  15      


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys 
        35                  40                  45              


Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Asn Ser 
65                  70                  75                  80  


Val Glu Thr Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Ser Gly 
                85                  90                  95      


Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  88
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  88
ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg       60

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      120

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      180

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      240

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttaa      300

taagcggccg ccggtggagg cggt                                             324


<210>  89
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  89

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  90
<211>  1602
<212>  DNA
<213>  Homo sapiens


<220>
<221>  exon
<222>  (1)..(298)

<220>
<221>  Intron
<222>  (299)..(689)

<220>
<221>  exon
<222>  (690)..(734)

<220>
<221>  Intron
<222>  (735)..(852)

<220>
<221>  exon
<222>  (853)..(1182)

<220>
<221>  Intron
<222>  (1183)..(1279)

<220>
<221>  exon
<222>  (1280)..(1602)

<400>  90
agt gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc         48
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser           
1               5                   10                  15                

aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac         96
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp           
            20                  25                  30                    

tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc        144
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr           
        35                  40                  45                        

agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac        192
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr           
    50                  55                  60                            

tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag        240
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln           
65                  70                  75                  80            

acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac        288
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp           
                85                  90                  95                

aag aga gtt g gtgagaggcc agcacaggga gggagggtgt ctgctggaag              338
Lys Arg Val                                                               
                                                                          

ccaggctcag cgctcctgcc tggacgcatc ccggctatgc agtcccagtc cagggcagca      398

aggcaggccc cgtctgcctc ttcacccgga ggcctctgcc cgccccactc atgctcaggg      458

agagggtctt ctggcttttt ccccaggctc tgggcaggca caggctaggt gcccctaacc      518

caggccctgc acacaaaggg gcaggtgctg ggctcagacc tgccaagagc catatccggg      578

aggaccctgc ccctgaccta agcccacccc aaaggccaaa ctctccactc cctcagctcg      638

gacaccttct ctcctcccag attccagtaa ctcccaatct tctctctgca g ag  ccc       694
                                                         Glu Pro          
                                                                          

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca g gtaagccagc       744
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro                       
            105                 110                                       

ccaggcctcg ccctccagct caaggcggga caggtgccct agagtagcct gcatccaggg      804

acaggcccca gccgggtgct gacacgtcca cctccatctc ttcctcag ca  cct gaa       860
                                                     Ala Pro Glu          
                                                                          

ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        908
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
        120                 125                 130                       

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        956
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
    135                 140                 145                           

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc       1004
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
150                 155                 160                 165           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac       1052
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
                170                 175                 180               

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1100
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
            185                 190                 195                   

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1148
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
        200                 205                 210                       

gcc ccc atc gag aaa acc atc tcc aaa gcc aaa g gtgggacccg              1192
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys                               
    215                 220                                               

tggggtgcga gggccacatg gacagaggcc ggctcggccc accctctgcc ctgagagtga     1252

ccgctgtacc aacctctgtc cctacag gg  cag ccc cga gaa cca cag gtg tac     1305
                              Gly Gln Pro Arg Glu Pro Gln Val Tyr         
                                                  230                     

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg       1353
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
    235                 240                 245                           

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg       1401
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
250                 255                 260                 265           

gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg       1449
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
                270                 275                 280               

ctg gac tcc gac ggc tcc ttc ttc ctc tat agc aag ctc acc gtg gac       1497
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
            285                 290                 295                   

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat       1545
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
        300                 305                 310                       

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tcc ccg       1593
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
    315                 320                 325                           

ggt aaa tga                                                           1602
Gly Lys                                                                   
330                                                                       


<210>  91
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  91

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
1               5                   10                  15      


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
65                  70                  75                  80  


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                85                  90                  95      


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            100                 105                 110         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
145                 150                 155                 160 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                165                 170                 175     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            180                 185                 190         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        195                 200                 205             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    210                 215                 220                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
225                 230                 235                 240 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            260                 265                 270         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330     


<210>  92
<211>  751
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic construct

<400>  92
ggcgcgccga ggtccaactg cagcaacctg ggtctgagct ggtgaggcct ggagcttcag       60

tgaagctgtc ctgcaaggct tctggctaca cattcaccag ctactggatg cactgggtga      120

agcagaggcc tggacaaggc cttgagtgga ttgggaatat ttatcctggt agtcgtagta      180

ctaactacga tgagaagttc aagagcaagg ccacactgac tgtagacaca tcctccagca      240

cagcctacat gcagctcagc agcctgacat ctgaggactc tgcggtctat tactgtacaa      300

gaaatgggga ttactacgtt agtagcgggg atgctatgga ctactggggt caaggaacct      360

cagtcaccgt ctcgtcagcc agcaccaagg gcccccaggt ccaactgcag cagcctgggg      420

ctgaactggt ggagcctggg ggttcagtga agctgtcctg caaggcttct ggctacacct      480

tcaccagtca ctggatgcac tgggtgaagc agaggcctgg acaaggcctt gagtggatag      540

gtgagattaa tcctagcagc ggtcgtaata actacaatga gaagttcaag agtaaggcca      600

cactgactgt agacaaatcc tccagcacag cctacatgca attcagcagc ctgacatctg      660

aggactctgc ggtctattat tgtgtaagat actatggtta cgacgaagct atggactact      720

ggggtcaagg aacctcagtc accgtctcga g                                     751


<210>  93
<211>  1017
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic construct

<400>  93
gctagccgac attcagatga ctcagactac atcctccctg tctgcctctc tgggagacag       60

agtcaccatc agttgcagga caagtcagga cattggcaat tatttaaact ggtatcagca      120

gaaaccagat ggaactgtta aactcctgat ctactacaca tcaagattac actcaggagt      180

cccatcaagg ttcagtggca gtgggtctgg aacagatttt tctctcacca ttaacaacgt      240

ggagcaagag gatgttgcca cttacttttg ccaacactat aatacggttc ctccgacgtt      300

cggtggaggc accaagctgg aaatcaaacg aactgtggct gcaccagaca tcgtgatgac      360

acaagctgca ttctccaatc cagtcactct tggaacatca gcttccatct cctgcaggtc      420

tagtaagagt ctcctacata gtaatggcat cacttatttg tattggtatc tgcagaagcc      480

aggccagtct cctcagctcc tgatttatca gatgtccaac cttgcctcag gagtcccaga      540

caggttcagt agcagtgggt caggaactga tttcacactg agaatcagca gagtggaggc      600

tgaggatgtg ggtgtttatt actgtgctca aaatctagaa cttccgtaca cgttcggagg      660

ggggaccaag ctggaaataa aacgaactgt ggctgcacca tctgtcttca tcttcccgcc      720

atctgatgag cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta      780

tcccagagag gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca      840

ggagagtgtc acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac      900

gctgagcaaa gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg      960

cctgagctcg cccgtcacaa agagcttcaa caggggagag tgttaataag cggccgc        1017


<210>  94
<211>  751
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic construct

<400>  94
ggcgcgccca ggtccaactg cagcagcctg gggctgaact ggtggagcct gggggttcag       60

tgaagctgtc ctgcaaggct tctggctaca ccttcaccag tcactggatg cactgggtga      120

agcagaggcc tggacaaggc cttgagtgga taggtgagat taatcctagc agcggtcgta      180

ataactacaa tgagaagttc aagagtaagg ccacactgac tgtagacaaa tcctccagca      240

cagcctacat gcaattcagc agcctgacat ctgaggactc tgcggtctat tattgtgtaa      300

gatactatgg ttacgacgaa gctatggact actggggtca aggaacctca gtcaccgtct      360

cgtcagccag caccaagggc cccgaggtcc aactgcagca acctgggtct gagctggtga      420

ggcctggagc ttcagtgaag ctgtcctgca aggcttctgg ctacacattc accagctact      480

ggatgcactg ggtgaagcag aggcctggac aaggccttga gtggattggg aatatttatc      540

ctggtagtcg tagtactaac tacgatgaga agttcaagag caaggccaca ctgactgtag      600

acacatcctc cagcacagcc tacatgcagc tcagcagcct gacatctgag gactctgcgg      660

tctattactg tacaagaaat ggggattact acgttagtag cggggatgct atggactact      720

ggggtcaagg aacctcagtc accgtctcga g                                     751


<210>  95
<211>  1017
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic construct

<400>  95
gctagccgac atcgtgatga cacaagctgc attctccaat ccagtcactc ttggaacatc       60

agcttccatc tcctgcaggt ctagtaagag tctcctacat agtaatggca tcacttattt      120

gtattggtat ctgcagaagc caggccagtc tcctcagctc ctgatttatc agatgtccaa      180

ccttgcctca ggagtcccag acaggttcag tagcagtggg tcaggaactg atttcacact      240

gagaatcagc agagtggagg ctgaggatgt gggtgtttat tactgtgctc aaaatctaga      300

acttccgtac acgttcggag gggggaccaa gctggaaata aaacgaactg tggctgcacc      360

agacattcag atgactcaga ctacatcctc cctgtctgcc tctctgggag acagagtcac      420

catcagttgc aggacaagtc aggacattgg caattattta aactggtatc agcagaaacc      480

agatggaact gttaaactcc tgatctacta cacatcaaga ttacactcag gagtcccatc      540

aaggttcagt ggcagtgggt ctggaacaga tttttctctc accattaaca acgtggagca      600

agaggatgtt gccacttact tttgccaaca ctataatacg gttcctccga cgttcggtgg      660

aggcaccaag ctggaaatca aacgaactgt ggctgcacca tctgtcttca tcttcccgcc      720

atctgatgag cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta      780

tcccagagag gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca      840

ggagagtgtc acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac      900

gctgagcaaa gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg      960

cctgagctcg cccgtcacaa agagcttcaa caggggagag tgttaataag cggccgc        1017


<210>  96
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct

<400>  96

Arg Ala Glu Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Pro Gly Ser Arg Ser Thr Asn Tyr Asp Glu 
    50                  55                  60                  


Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asn Gly Asp Tyr Tyr Val Ser Ser Gly Asp Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Glu 
    130                 135                 140                 


Pro Gly Gly Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Ser His Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Glu Ile Asn Pro Ser Ser Gly Arg Asn Asn Tyr Asn 
            180                 185                 190         


Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Val Arg Tyr Tyr Gly Tyr Asp Glu Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Ser Val Thr Val Ser 
                245                 


<210>  97
<211>  334
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct

<400>  97

Leu Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile Gly 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Asn Asn Val 
65                  70                  75                  80  


Glu Gln Glu Asp Val Ala Thr Tyr Phe Cys Gln His Tyr Asn Thr Val 
                85                  90                  95      


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val 
        115                 120                 125             


Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
    130                 135                 140                 


Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro 
145                 150                 155                 160 


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser 
                165                 170                 175     


Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr 
            180                 185                 190         


Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
        195                 200                 205             


Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
    210                 215                 220                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                245                 250                 255     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            260                 265                 270         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        275                 280                 285             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    290                 295                 300                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
305                 310                 315                 320 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                325                 330                 


<210>  98
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct

<400>  98

Arg Ala Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Glu Pro 
1               5                   10                  15      


Gly Gly Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser His Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Asn Pro Ser Ser Gly Arg Asn Asn Tyr Asn Glu 
    50                  55                  60                  


Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Tyr Tyr Gly Tyr Asp Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
145                 150                 155                 160 


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Asn Ile Tyr Pro Gly Ser Arg Ser Thr Asn Tyr Asp Glu Lys Phe Lys 
            180                 185                 190         


Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Arg Asn Gly Asp Tyr Tyr Val Ser Ser Gly Asp Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Ser Val Thr Val Ser 
                245                 


<210>  99
<211>  334
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct

<400>  99

Leu Ala Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr 
1               5                   10                  15      


Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu 
            20                  25                  30          


His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly 
        35                  40                  45              


Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Thr Val Ala Ala Pro Asp Ile Gln Met Thr Gln Thr Thr 
        115                 120                 125             


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
    130                 135                 140                 


Thr Ser Gln Asp Ile Gly Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
145                 150                 155                 160 


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
                165                 170                 175     


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
            180                 185                 190         


Leu Thr Ile Asn Asn Val Glu Gln Glu Asp Val Ala Thr Tyr Phe Cys 
        195                 200                 205             


Gln His Tyr Asn Thr Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
    210                 215                 220                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                245                 250                 255     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            260                 265                 270         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        275                 280                 285             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    290                 295                 300                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
305                 310                 315                 320 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                325                 330                 


<210>  100
<211>  1863
<212>  DNA
<213>  Macaca fascicularis

<400>  100
ctggaggaaa agaaagtttg ccaaggcacg agtaacaaac tcacgcagtt gggcactttt       60

gaagatcatt ttctcagcct ccagaggatg ttcaataact gtgaggtggt ccttgggaat      120

ttggaaatta cctacgtgca gaggaattat gatctttcct tcttaaagac catccaggag      180

gtggctggtt atgtcctcat cgccctcaac acagtggagc ggattccttt ggaaaacctg      240

cagatcatca gaggaaacat gtactatgaa aattcctatg ccttagcagt cttatctaac      300

tatgatgcaa ataaaaccgg actgaaggag ctgcccatga gaaacttaca ggaaatcctg      360

catggcgccg tgcggttcag caacaaccct gccctgtgca acgtggagag catccagtgg      420

cgggacatag tcagcagcga gtttctcagc aacatgtcga tggacttcca gaaccacctg      480

ggcagctgcc aaaagtgtga tccaagctgt cccaatggga gctgctgggg tgcaggagag      540

gagaactgcc agaaactgac caaaatcatc tgtgcccagc agtgctccgg gcgctgccgc      600

ggcaagtccc ccagtgactg ctgccacaac cagtgtgccg cgggctgcac gggcccccgg      660

gagagcgact gcctggtctg ccgcaaattc cgagacgaag ccacgtgcaa ggacacctgc      720

cccccactca tgctctacaa ccccaccaca taccagatgg atgtgaaccc cgagggcaaa      780

tacagctttg gtgccacctg cgtgaagaag tgtccccgta attatgtggt gacagatcac      840

ggctcgtgcg tccgagcctg cggggccgac agctatgaga tggaggaaga cggcgtccgc      900

aagtgtaaga agtgcgaagg gccttgccgc aaagtgtgta atggaatagg tattggtgaa      960

tttaaagaca cactctccat aaatgctaca aatattaaac acttcaaaaa ctgcacctcc     1020

atcagtggcg atctccacat cctgccggtg gcatttaggg gtgactcctt cacacacact     1080

ccgcctctgg atccacagga actggatatt ctgaaaaccg taaaggaaat cacagggttt     1140

ttgctgattc aggcttggcc tgaaaacagg acggacctcc atgcttttga gaacctagaa     1200

atcatacgtg gcaggaccaa gcaacacggt cagttttctc ttgcggtcgt cagcctgaac     1260

ataacatcct tgggattacg ctccctcaag gagataagcg atggagatgt gataatttca     1320

ggaaacaaaa atttgtgcta tgcaaataca ataaactgga aaaaactgtt tgggacctcc     1380

agtcagaaaa ccaaaattat aagcaacaga ggtgaaaaca gctgcaaggc cacgggccag     1440

gtctgccatg ccttgtgctc ccccgagggc tgctggggcc cggagcccag ggactgcgtc     1500

tcctgccaga atgtcagccg aggcagagaa tgcgtggaca agtgcaacat cctggagggc     1560

gagccaaggg agtttgtgga gaactctgag tgcatacagt gccacccaga atgcctgccc     1620

caggtcatga acatcacctg cacaggacgg ggaccagaca actgtatcca gtgtgcccac     1680

tacattgacg gcccccactg cgtcaagacc tgcccagcag gagtcatggg agaaaacaac     1740

accctggtct ggaagtacgc agacgccggc cacgtgtgcc acctgtgcca tccaaactgc     1800

acctacggat gcactgggcc aggtcttgaa ggctgtgcaa ggaacgggcc taagatccca     1860

tcc                                                                   1863


<210>  101
<211>  621
<212>  PRT
<213>  Macaca fascicularis

<400>  101

Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln 
1               5                   10                  15      


Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn 
            20                  25                  30          


Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg 
        35                  40                  45              


Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr 
    50                  55                  60                  


Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu 
65                  70                  75                  80  


Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro 
            100                 105                 110         


Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn 
        115                 120                 125             


Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val 
    130                 135                 140                 


Ser Ser Glu Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu 
145                 150                 155                 160 


Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp 
                165                 170                 175     


Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala 
            180                 185                 190         


Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys 
        195                 200                 205             


His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys 
    210                 215                 220                 


Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys 
225                 230                 235                 240 


Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn 
                245                 250                 255     


Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro 
            260                 265                 270         


Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
        275                 280                 285             


Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
    290                 295                 300                 


Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
305                 310                 315                 320 


Phe Lys Asp Thr Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
                325                 330                 335     


Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
            340                 345                 350         


Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
        355                 360                 365             


Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
    370                 375                 380                 


Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
385                 390                 395                 400 


Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
                405                 410                 415     


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
            420                 425                 430         


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
        435                 440                 445             


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Ser Gln Lys Thr 
    450                 455                 460                 


Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
465                 470                 475                 480 


Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
                485                 490                 495     


Arg Asp Cys Val Ser Cys Gln Asn Val Ser Arg Gly Arg Glu Cys Val 
            500                 505                 510         


Asp Lys Cys Asn Ile Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
        515                 520                 525             


Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Val Met Asn 
    530                 535                 540                 


Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
545                 550                 555                 560 


Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
                565                 570                 575     


Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
            580                 585                 590         


Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
        595                 600                 605             


Leu Glu Gly Cys Ala Arg Asn Gly Pro Lys Ile Pro Ser 
    610                 615                 620     


<210>  102
<211>  3633
<212>  DNA
<213>  Macaca fascicularis

<400>  102
atgcgaccct ccgggacggc cggggccgcg ctcctggcgc tgctggctgc gctttgcccc       60

gcgagtcggg ctctggagga aaagaaagtt tgccaaggca cgagtaacaa actcacgcag      120

ttgggcactt ttgaagatca ttttctcagc ctccagagga tgttcaataa ctgtgaggtg      180

gtccttggga atttggaaat tacctacgtg cagaggaatt atgatctttc cttcttaaag      240

accatccagg aggtggctgg ttatgtcctc atcgccctca acacagtgga gcggattcct      300

ttggaaaacc tgcagatcat cagaggaaac atgtactatg aaaattccta tgccttagca      360

gtcttatcta actatgatgc aaataaaacc ggactgaagg agctgcccat gagaaactta      420

caggaaatcc tgcatggcgc cgtgcggttc agcaacaacc ctgccctgtg caacgtggag      480

agcatccagt ggcgggacat agtcagcagc gagtttctca gcaacatgtc gatggacttc      540

cagaaccacc tgggcagctg ccaaaagtgt gatccaagct gtcccaatgg gagctgctgg      600

ggtgcaggag aggagaactg ccagaaactg accaaaatca tctgtgccca gcagtgctcc      660

gggcgctgcc gcggcaagtc ccccagtgac tgctgccaca accagtgtgc cgcgggctgc      720

acgggccccc gggagagcga ctgcctggtc tgccgcaaat tccgagacga agccacgtgc      780

aaggacacct gccccccact catgctctac aaccccacca cataccagat ggatgtgaac      840

cccgagggca aatacagctt tggtgccacc tgcgtgaaga agtgtccccg taattatgtg      900

gtgacagatc acggctcgtg cgtccgagcc tgcggggccg acagctatga gatggaggaa      960

gacggcgtcc gcaagtgtaa gaagtgcgaa gggccttgcc gcaaagtgtg taatggaata     1020

ggtattggtg aatttaaaga cacactctcc ataaatgcta caaatattaa acacttcaaa     1080

aactgcacct ccatcagtgg cgatctccac atcctgccgg tggcatttag gggtgactcc     1140

ttcacacaca ctccgcctct ggatccacag gaactggata ttctgaaaac cgtaaaggaa     1200

atcacagggt ttttgctgat tcaggcttgg cctgaaaaca ggacggacct ccatgctttt     1260

gagaacctag aaatcatacg tggcaggacc aagcaacacg gtcagttttc tcttgcggtc     1320

gtcagcctga acataacatc cttgggatta cgctccctca aggagataag cgatggagat     1380

gtgataattt caggaaacaa aaatttgtgc tatgcaaata caataaactg gaaaaaactg     1440

tttgggacct ccagtcagaa aaccaaaatt ataagcaaca gaggtgaaaa cagctgcaag     1500

gccacgggcc aggtctgcca tgccttgtgc tcccccgagg gctgctgggg cccggagccc     1560

agggactgcg tctcctgtca gaatgtcagc cgaggcagag aatgcgtgga caagtgcaac     1620

atcctggagg gcgagccaag ggagtttgtg gagaactctg agtgcataca gtgtcaccca     1680

gaatgcctgc cccaggtcat gaacatcacc tgcacaggac ggggaccaga caactgtatc     1740

cagtgtgccc actacattga cggcccccac tgcgtcaaga cctgcccagc aggagtcatg     1800

ggagaaaaca acaccctggt ctggaagtac gcagacgccg gccacgtgtg ccacctgtgc     1860

catccaaact gcacctacgg atgcactggg ccaggtcttg aaggctgtgc aaggaacggg     1920

cctaagatcc catccatcgc cactgggatg gtgggggccc tcctcttgct gctggtggtg     1980

gccctgggga tcggcctctt catgcgaagg cgccacatcg ttcggaagcg cacactgcgg     2040

aggctgctgc aggagaggga gcttgtggag cctcttacgc ccagtggaga agctcccaac     2100

caagctctct tgaggatctt gaaggaaact gaattcaaga agatcaaagt gctgggctcc     2160

ggtgcgttcg gaactgtgta taagggactc tggatcccag aaggtgagaa agttaaaatt     2220

cccgtcgcta tcaaggaatt aagagaagca acatctccga aagccaacaa ggaaatcctc     2280

gatgaagcct acgtgatggc cagcgtggac aacccccatg tgtgccgcct gctgggcatc     2340

tgcctcacct ccaccgtgca gctcattacg cagctcatgc ccttcggctg cctcctggac     2400

tacgtccggg aacacaagga caatatcggc tcccagtacc tgctcaactg gtgtgtgcag     2460

attgcaaagg gcatgaacta cttggaggac cggcgcttgg tgcaccgcga cctggcagcc     2520

aggaacgtac tggtgaaaac gccacagcat gtcaagatca cagattttgg gctggccaaa     2580

ctgctgggtg cagaagagaa agaataccat gcagaaggag gcaaagtgcc tatcaagtgg     2640

atggcgttgg aatcaatttt acaccgaatt tatacccacc agagtgatgt ctggagctac     2700

ggggtgaccg tttgggagtt gatgaccttt ggatccaagc catatgacgg aatccctgcc     2760

agcgagatct cctccatcct ggagaaagga gaacgcctcc cccagccacc catatgtacc     2820

atcgatgtct acatgatcat ggtcaagtgc tggatgatag acgcagatag tcgcccaaag     2880

ttccgtgagt tgatcattga attctccaaa atggcccgag acccccagcg ctaccttgtt     2940

attcaggggg atgaaagaat gcatttgcca agccctacag actccaactt ctaccgtgcc     3000

ctgatggatg aagaagacat ggacgacgtg gtggatgccg acgagtacct catcccacag     3060

caaggcttct tcagcagccc ctccacgtca cggactcccc tcctgagctc tctgagtgca     3120

actagcaaca attccactgt ggcttgcatt gatagaaatg ggctgcaaag ctgttccatc     3180

aaggaagaca gcttcttaca gcgatacagc tcagacccca caggcgcctt gactgaggac     3240

agcatagacg acaccttcct cccagtgcct gaatacataa accagtctgt tcccaaaagg     3300

cccgctggct ctgtgcagaa tcctgtctat cacaatcagc ctctgaaccc tgcgcccagc     3360

agagacccac actaccagga cccccacagc accgcagtgg gcaaccccga gtatctcaac     3420

actgtccagc ccacctgtgt caacagcaca ttcgacagcc ctgctcattg ggcccagaaa     3480

ggcagccacc aaattagcct ggacaaccct gactaccagc aggacttctt tcccaaggaa     3540

gccaagccaa atggcatctt taagggctcc acagctgaaa atgcagaata cctaagggtc     3600

gcaccacaaa gcagtgaatt tattggagca tga                                  3633


<210>  103
<211>  1210
<212>  PRT
<213>  Macaca fascicularis

<400>  103

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Glu Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Thr Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Ser Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Gln Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Ile Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Val Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Ala Arg Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Ser Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  104
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Ser Arg Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asn Gly Asp Tyr Tyr Val Ser Ser Gly Asp Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  105
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Tyr Asn Thr Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  106
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct

<400>  106

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ser Ser Gly Arg Asn Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Tyr Asp Glu Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser 
        115             


<210>  107
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct

<400>  107

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  108
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  108

Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln 
1               5                   10                  15      


Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn 
            20                  25                  30          


Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg 
        35                  40                  45              


Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr 
    50                  55                  60                  


Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu 
65                  70                  75                  80  


Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro 
            100                 105                 110         


Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn 
        115                 120                 125             


Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val 
    130                 135                 140                 


Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu 
145                 150                 155                 160 


Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp 
                165                 170                 175     


Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala 
            180                 185                 190         


Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys 
        195                 200                 205             


His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys 
    210                 215                 220                 


Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys 
225                 230                 235                 240 


Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn 
                245                 250                 255     


Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro 
            260                 265                 270         


Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
        275                 280                 285             


Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
    290                 295                 300                 


Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
305                 310                 315                 320 


Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
                325                 330                 335     


Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
            340                 345                 350         


Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
        355                 360                 365             


Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
    370                 375                 380                 


Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
385                 390                 395                 400 


Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
                405                 410                 415     


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
            420                 425                 430         


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
        435                 440                 445             


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr 
    450                 455                 460                 


Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
465                 470                 475                 480 


Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
                485                 490                 495     


Lys Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val 
            500                 505                 510         


Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
        515                 520                 525             


Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn 
    530                 535                 540                 


Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
545                 550                 555                 560 


Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
                565                 570                 575     


Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
            580                 585                 590         


Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
        595                 600                 605             


Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser 
    610                 615                 620     


<210>  109
<211>  616
<212>  PRT
<213>  artificial

<220>
<223>  Consensus sequence

<400>  109

Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln 
1               5                   10                  15      


Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn 
            20                  25                  30          


Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg 
        35                  40                  45              


Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr 
    50                  55                  60                  


Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu 
65                  70                  75                  80  


Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro 
            100                 105                 110         


Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn 
        115                 120                 125             


Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val 
    130                 135                 140                 


Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu 
145                 150                 155                 160 


Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp 
                165                 170                 175     


Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala 
            180                 185                 190         


Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys 
        195                 200                 205             


His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys 
    210                 215                 220                 


Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys 
225                 230                 235                 240 


Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn 
                245                 250                 255     


Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro 
            260                 265                 270         


Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
        275                 280                 285             


Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
    290                 295                 300                 


Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
305                 310                 315                 320 


Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
                325                 330                 335     


Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
            340                 345                 350         


Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
        355                 360                 365             


Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
    370                 375                 380                 


Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
385                 390                 395                 400 


Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
                405                 410                 415     


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
            420                 425                 430         


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
        435                 440                 445             


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gln Lys Thr Lys 
    450                 455                 460                 


Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val 
465                 470                 475                 480 


Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Lys 
                485                 490                 495     


Asp Cys Val Ser Cys Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys 
            500                 505                 510         


Cys Asn Ile Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu 
        515                 520                 525             


Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Met Asn Ile Thr Cys 
    530                 535                 540                 


Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp 
545                 550                 555                 560 


Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn 
                565                 570                 575     


Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu 
            580                 585                 590         


Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly 
        595                 600                 605             


Cys Asn Gly Pro Lys Ile Pro Ser 
    610                 615     


<210>  110
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  110

Cys Thr Arg Asn Gly Asp Tyr Tyr Ile Ser Ser Gly Asp Ala Met Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  111
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  111

Cys Thr Arg Asn Gly Asp Tyr Tyr Val Ser Ser Gly Asp Ala Met Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  112
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  112

Cys Ala Arg Gly Ser Asp Gly Tyr Phe Tyr Ala Met Asp Tyr Trp 
1               5                   10                  15  


<210>  113
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  113

Cys Ala Arg Tyr Tyr Gly Tyr Asp Asp Ala Met Asp Tyr Trp 
1               5                   10                  


<210>  114
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  114

Cys Val Arg Tyr Tyr Gly Tyr Asp Glu Ala Met Asp Tyr Trp 
1               5                   10                  


<210>  115
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  115

Cys Val Arg Tyr Tyr Gly Tyr Asp Glu Val Met Asp Tyr Trp 
1               5                   10                  


<210>  116
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  116

Cys Gln His Tyr Asn Thr Val Pro Pro Thr Phe 
1               5                   10      


<210>  117
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  117

Cys Gln Gln Phe Thr Thr Ser Pro Phe Thr Phe 
1               5                   10      


<210>  118
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  118

Cys Gln His Tyr Asn Thr Val Pro Pro Thr Phe 
1               5                   10      


<210>  119
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  119

Cys Gln His Ser Arg Glu Phe Pro Leu Thr Phe 
1               5                   10      


<210>  120
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  120

Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe 
1               5                   10      


<210>  121
<211>  35
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  121
ggaggcgctc gagacggtga ctgaggttcc ttgac                                  35


<210>  122
<211>  52
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  122
ccagccgggg cgcgccgagg tccaactgca gcaacctggg tctgagctgg tg               52


<210>  123
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  123
ccagccgggg cgcgcccagg tccaactgca gcagcctggg gctgaactg                   49


<210>  124
<211>  50
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  124
catgggaata gctagccgac attcagatga ctcagactac atcctccctg                  50


<210>  125
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  125
catgggaata gctagccgac atcgtgatga cacaagctgc attctccaat c                51


<210>  126
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  126
accgcctcca ccggcggccg cttattaaca ctctcccctg ttg                         43


<210>  127
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  127
ctgggggccc ttggtgctgg ctgacgagac ggtgactgag gttc                        44


<210>  128
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  128
gccagcacca agggccccca ggtccaactg cagcagc                                37


<210>  129
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  129
cggggccctt ggtgctggct gacgagacgg tgactgag                               38


<210>  130
<211>  37
<212>  DNA
<213>  PCR primer

<400>  130
gccagcacca agggccccga ggtccaactg cagcaac                                37


<210>  131
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  131
gtctggtgca gccacagttc gtttgatttc cagcttggtg                             40


<210>  132
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  132
cgaactgtgg ctgcaccaga catcgtgatg acacaagc                               38


<210>  133
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  133
gtctggtgca gccacagttc gttttatttc cagcttggtc c                           41


<210>  134
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  134
cgaactgtgg ctgcaccaga cattcagatg actcagacta c                           41


<210>  135
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  135
tcttcgggaa gcagctatgc                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  136
ttctccactg ggcgtaagag                                                   20


<210>  137
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  137
atctgcattc tagactggag gaaaagaaag tttgccaagg c                           41


<210>  138
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  138
tactcgatga cgcgtttagg atgggatctt aggcccgttc c                           41


<210>  139
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  139
tcatgctcca ataaattcac tg                                                22


<210>  140
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  140
ggagtcggcg gccgcaccat gcgaccctcc gggacgg                                37


<210>  141
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  141
gcatgtgact cgagtcatgc tccaataaat tcactgc                                37


