
SEQUENCE LISTING

<110> AGENSYS, INC.
      KANNER, Steven B.
      JAKOBOVITS, Aya
      GUDAS, Jean
      RAITANO, Arthur B.
      MORRISON, Robert Kendall
      CHALLITA-EID, Pia M.
      JIA, Xiao-chi

<120> ANTIBODIES AND RELATED MOLECULES THAT
      BIND TO 58P1D12 PROTEINS

<130> 511582002082

<140> Not Yet Assigned          
<141> Concurrently Herewith 

<150> 61/207,862          
<151> 2008-08-20 

<150> 61/153,225
<151> 2009-02-17      

<160> 19

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2550
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (380)...(1201)

<400> 1
atccaggacc agggcgcacc ggctcagcct ctcacttgtc agaggccggg gaagagaagc 60
aaagcgcaac ggtgtggtcc aagccggggc ttctgcttcg cctctaggac atacacggga 120
ccccctaact tcagtccccc aaacgcgcac cctcgaagtc ttgaactcca gccccgcaca 180
tccacgcgcg gcacaggcgc ggcaggcggc aggtcccggc cgaaggcgat gcgcgcaggg 240
ggtcgggcag ctgggctcgg gcggcgggag tagggcccgg cagggaggca gggaggctgc 300
agagtcagag tcgcgggctg cgccctgggc agaggccgcc ctcgctccac gcaacacctg 360
ctgctgccac cgcgccgcg atg agc cgc gtg gtc tcg ctg ctg ctg ggc gcc  412
                     Met Ser Arg Val Val Ser Leu Leu Leu Gly Ala
                      1               5                   10
 
gcg ctg ctc tgc ggc cac gga gcc ttc tgc cgc cgc gtg gtc agc ggc   460
Ala Leu Leu Cys Gly His Gly Ala Phe Cys Arg Arg Val Val Ser Gly
             15                  20                  25
 
caa aag gtg tgt ttt gct gac ttc aag cat ccc tgc tac aaa atg gcc   508
Gln Lys Val Cys Phe Ala Asp Phe Lys His Pro Cys Tyr Lys Met Ala
         30                  35                  40
 
tac ttc cat gaa ctg tcc agc cga gtg agc ttt cag gag gca cgc ctg   556
Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu
     45                  50                  55
 
gct tgt gag agt gag gga gga gtc ctc ctc agc ctt gag aat gaa gca   604
Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala
 60                  65                  70                  75
 
gaa cag aag tta ata gag agc atg ttg caa aac ctg aca aaa ccc ggg   652
Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly
                 80                  85                  90
 
aca ggg att tct gat ggt gat ttc tgg ata ggg ctt tgg agg aat gga   700
Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly
             95                 100                 105
 
gat ggg caa aca tct ggt gcc tgc cca gat ctc tac cag tgg tct gat   748
Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp
        110                 115                 120
 
gga agc aat tcc cag tac cga aac tgg tac aca gat gaa cct tcc tgc   796
Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys
    125                 130                 135
 
gga agt gaa aag tgt gtt gtg atg tat cac caa cca act gcc aat cct   844
Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala Asn Pro
140                 145                 150                 155
 
ggc ctt ggg ggt ccc tac ctt tac cag tgg aat gat gac agg tgt aac   892
Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn
                160                 165                 170
 
atg aag cac aat tat att tgc aag tat gaa cca gag att aat cca aca   940
Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr
            175                 180                 185
 
gcc cct gta gaa aag cct tat ctt aca aat caa cca gga gac acc cat   988
Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His
        190                 195                 200
 
cag aat gtg gtt gtt act gaa gca ggt ata att ccc aat cta att tat   1036
Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu Ile Tyr
    205                 210                 215
 
gtt gtt ata cca aca ata ccc ctg ctc tta ctg ata ctg gtt gct ttt   1084
Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val Ala Phe
220                 225                 230                 235
 
gga acc tgt tgt ttc cag atg ctg cat aaa agt aaa gga aga aca aaa   1132
Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg Thr Lys
                240                 245                 250
 
act agt cca aac cag tct aca ctg tgg att tca aag agt acc aga aaa   1180
Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr Arg Lys
            255                 260                 265
 
gaa agt ggc atg gaa gta taa taactcattg acttggttcc agaattttgt      1231
Glu Ser Gly Met Glu Val  *
        270
 
aattctggat ctgtataagg aatggcatca gaacaatagc ttggaatggc ttgaaatcac 1291
aaaggatctg caagatgaac tgtaagctcc cccttgaggc aaatattaaa gtaattttta 1351
tatgtctatt atttcattta aagaatatgc tgtgctaata atggagtgag acatgcttat 1411
tttgctaaag gatgcaccca aacttcaaac ttcaagcaaa tgaaatggac aatgcagata 1471
aagttgttat caacacgtcg ggagtatgtg tgttagaagc aattcctttt atttctttca 1531
cctttcataa gttgttatct agtcaatgta atgtatattg tattgaaatt tacagtgtgc 1591
aaaagtattt tacctttgca taagtgtttg ataaaaatga actgttctaa tatttatttt 1651
tatggcatct catttttcaa tacatgctct tttgattaaa gaaacttatt actgttgtca 1711
actgaattca cacacacaca aatatagtac catagaaaaa gtttgttttc tcgaaataat 1771
tcatctttca gcttctctgc ttttggtcaa tgtctaggaa atctcttcag aaataagaag 1831
ctatttcatt aagtgtgata taaacctcct caaacatttt acttagaggc aaggattgtc 1891
taatttcaat tgtgcaagac atgtgcctta taattatttt tagcttaaaa ttaaacagat 1951
tttgtaataa tgtaactttg ttaataggtg cataaacact aatgcagtca atttgaacaa 2011
aagaagtgac atacacaata taaatcatat gtcttcacac gttgcctata taatgagaag 2071
cagctctctg agggttctga aatcaatgtg gtccctctct tgcccactaa acaaagatgg 2131
ttgttcgggg tttgggattg acactggagg cagatagttg caaagttagt ctaaggtttc 2191
cctagctgta tttagcctct gactatatta gtatacaaag aggtcatgtg gttgagacca 2251
ggtgaatagt cactatcagt gtggagacaa gcacagcaca cagacatttt aggaaggaaa 2311
ggaactacga aatcgtgtga aaatgggttg gaacccatca gtgatcgcat attcattgat 2371
gagggtttgc ttgagataga aaatggtggc tcctttctgt cttatctcct agtttcttca 2431
atgcttacgc cttgttcttc tcaagagaaa gttgtaactc tctggtcttc atatgtccct 2491
gtgctccttt taaccaaata aagagttctt gtttctgaag aaaaaaaaaa aaaaaaaaa  2550

<210> 2
<211> 273
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Arg Val Val Ser Leu Leu Leu Gly Ala Ala Leu Leu Cys Gly
 1               5                  10                  15      
His Gly Ala Phe Cys Arg Arg Val Val Ser Gly Gln Lys Val Cys Phe
            20                  25                  30          
Ala Asp Phe Lys His Pro Cys Tyr Lys Met Ala Tyr Phe His Glu Leu
        35                  40                  45              
Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu
    50                  55                  60                  
Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile
65                  70                  75                  80  
Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp
                85                  90                  95      
Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser
            100                 105                 110         
Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln
        115                 120                 125             
Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys
    130                 135                 140                 
Val Val Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro
145                 150                 155                 160 
Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr
                165                 170                 175     
Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys
            180                 185                 190         
Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val
        195                 200                 205             
Thr Glu Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr
    210                 215                 220                 
Ile Pro Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe
225                 230                 235                 240 
Gln Met Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln
                245                 250                 255     
Ser Thr Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu
            260                 265                 270         
Val
    


<210> 3
<211> 2418
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (388)...(1086)

<400> 3
ctgtggtgtt tttcccccgc tcctctggct gccttcctga tggatctctg tggtcccagg 60
caggaatggc ctgcttgggg acccagcgag ctcccaaggc ctttcctgct gcttcctcta 120
tccctgtgtt ttgcttggct ctctaaattg actcagctcc aggacatcag gaccccaggt 180
tctctggtct tgggactctg agacttgcac caggaatcct gcccaggctc tcaggccttt 240
ggactcagac tgagctactt cactggcttt cctggttctc cagcttgaag atggcagatc 300
gtgggacttc tcagcctcca taattgagtg agccaattcc ctggccaaaa ggtgtgtttt 360
gctgacttca agcatccctg ctacaaa atg gcc tac ttc cat gaa ctg tcc agc 414
                              Met Ala Tyr Phe His Glu Leu Ser Ser
                               1               5
 
cga gtg agc ttt cag gag gca cgc ctg gct tgt gag agt gag gga gga   462
Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu Gly Gly
 10                  15                  20                  25
 
gtc ctc ctc agc ctt gag aat gaa gca gaa cag aag tta ata gag agc   510
Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile Glu Ser
                 30                  35                  40
 
atg ttg caa aac ctg aca aaa ccc ggg aca ggg att tct gat ggt gat   558
Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp Gly Asp
             45                  50                  55
 
ttc tgg ata ggg ctt tgg agg aat gga gat ggg caa aca tct ggt gcc   606
Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser Gly Ala
         60                  65                  70
 
tgc cca gat ctc tac cag tgg tct gat gga agc aat tcc cag tac cga   654
Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln Tyr Arg
     75                  80                  85
 
aac tgg tac aca gat gaa cct tcc tgc gga agt gaa aag tgt gtt gtg   702
Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys Val Val
 90                  95                 100                 105
 
atg tat cac caa cca act gcc aat cct ggc ctt ggg ggt ccc tac ctt   750
Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro Tyr Leu
                110                 115                 120
 
tac cag tgg aat gat gac agg tgt aac atg aag cac aat tat att tgc   798
Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr Ile Cys
            125                 130                 135
 
aag tat gaa cca gag att aat cca aca gcc cct gta gaa aag cct tat   846
Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys Pro Tyr
        140                 145                 150
 
ctt aca aat caa cca gga gac acc cat cag aat gtg gtt gtt act gaa   894
Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val Thr Glu
    155                 160                 165
 
gca ggt ata att ccc aat cta att tat gtt gtt ata cca aca ata ccc   942
Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr Ile Pro
170                 175                 180                 185
 
ctg ctc tta ctg ata ctg gtt gct ttt gga acc tgt tgt ttc cag atg   990
Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe Gln Met
                190                 195                 200
 
ctg cat aaa agt aaa gga aga aca aaa act agt cca aac cag tct aca   1038
Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln Ser Thr
            205                 210                 215
 
ctg tgg att tca aag agt acc aga aaa gaa agt ggc atg gaa gta taa   1086
Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu Val  *
        220                 225                 230
 
taactcattg acttggttcc agaattttgt aattctggat ctgtataagg aatggcatca 1146
gaacaatagc ttggaatggc ttgaaatcac aaaggatctg caagatgaac tgtaagctcc 1206
cccttgaggc aaatattaaa gtaattttta tatgtctatt atttcattta aagaatatgc 1266
tgtgctaata atggagtgag acatgcttat tttgctaaag gatgcaccca aacttcaaac 1326
ttcaagcaaa tgaaatggac aatgcagata aagttgttat caacacgtcg ggagtatgtg 1386
tgttagaagc aattcctttt atttctttca cctttcataa gttgttatct agtcaatgta 1446
atgtatattg tattgaaatt tacagtgtgc aaaagtattt tacctttgca taagtgtttg 1506
ataaaaatga actgttctaa tatttatttt tatggcatct catttttcaa tacatgctct 1566
tttgattaaa gaaacttatt actgttgtca actgaattca cacacacaca aatatagtac 1626
catagaaaaa gtttgttttc tcgaaataat tcatctttca gcttctctgc ttttggtcaa 1686
tgtctaggaa atctcttcag aaataagaag ctatttcatt aagtgtgata taaacctcct 1746
caaacatttt acttagaggc aaggattgtc taatttcaat tgtgcaagac atgtgcctta 1806
taattatttt tagcttaaaa ttaaacagat tttgtaataa tgtaactttg ttaataggtg 1866
cataaacact aatgcagtca atttgaacaa aagaagtgac atacacaata taaatcatat 1926
gtcttcacac gttgcctata taatgagaag cagctctctg agggttctga aatcaatgtg 1986
gtccctctct tgcccactaa acaaagatgg ttgttcgggg tttgggattg acactggagg 2046
cagatagttg caaagttagt ctaaggtttc cctagctgta tttagcctct gactatatta 2106
gtatacaaag aggtcatgtg gttgagacca ggtgaatagt cactatcagt gtggagacaa 2166
gcacagcaca cagacatttt aggaaggaaa ggaactacga aatcgtgtga aaatgggttg 2226
gaacccatca gtgatcgcat attcattgat gagggtttgc ttgagataga aaatggtggc 2286
tcctttctgt cttatctcct agtttcttca atgcttacgc cttgttcttc tcaagagaaa 2346
gttgtaactc tctggtcttc atatgtccct gtgctccttt taaccaaata aagagttctt 2406
gtttctgaag aa                                                     2418

<210> 4
<211> 232
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 5
<211> 2236
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (206)...(904)

<400> 5
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
gaatacaaca agaagatggc catctgtaga ccaggaggtg gtccctcccc agaaactgga 120
tgggccagca cgttgattct gagcttctag cctccagaac tgccaaaagg tgtgttttgc 180
tgacttcaag catccctgct acaaa atg gcc tac ttc cat gaa ctg tcc agc   232
                            Met Ala Tyr Phe His Glu Leu Ser Ser
                             1               5
 
cga gtg agc ttt cag gag gca cgc ctg gct tgt gag agt gag gga gga   280
Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu Gly Gly
 10                  15                  20                  25
 
gtc ctc ctc agc ctt gag aat gaa gca gaa cag aag tta ata gag agc   328
Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile Glu Ser
                 30                  35                  40
 
atg ttg caa aac ctg aca aaa ccc ggg aca ggg att tct gat ggt gat   376
Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp Gly Asp
             45                  50                  55
 
ttc tgg ata ggg ctt tgg agg aat gga gat ggg caa aca tct ggt gcc   424
Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser Gly Ala
         60                  65                  70
 
tgc cca gat ctc tac cag tgg tct gat gga agc aat tcc cag tac cga   472
Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln Tyr Arg
     75                  80                  85
 
aac tgg tac aca gat gaa cct tcc tgc gga agt gaa aag tgt gtt gtg   520
Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys Val Val
 90                  95                 100                 105
 
atg tat cac caa cca act gcc aat cct ggc ctt ggg ggt ccc tac ctt   568
Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro Tyr Leu
                110                 115                 120
 
tac cag tgg aat gat gac agg tgt aac atg aag cac aat tat att tgc   616
Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr Ile Cys
            125                 130                 135
 
aag tat gaa cca gag att aat cca aca gcc cct gta gaa aag cct tat   664
Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys Pro Tyr
        140                 145                 150
 
ctt aca aat caa cca gga gac acc cat cag aat gtg gtt gtt act gaa   712
Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val Thr Glu
    155                 160                 165
 
gca ggt ata att ccc aat cta att tat gtt gtt ata cca aca ata ccc   760
Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr Ile Pro
170                 175                 180                 185
 
ctg ctc tta ctg ata ctg gtt gct ttt gga acc tgt tgt ttc cag atg   808
Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe Gln Met
                190                 195                 200
 
ctg cat aaa agt aaa gga aga aca aaa act agt cca aac cag tct aca   856
Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln Ser Thr
            205                 210                 215
 
ctg tgg att tca aag agt acc aga aaa gaa agt ggc atg gaa gta taa   904
Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu Val  *
        220                 225                 230
 
taactcattg acttggttcc agaattttgt aattctggat ctgtataagg aatggcatca 964
gaacaatagc ttggaatggc ttgaaatcac aaaggatctg caagatgaac tgtaagctcc 1024
cccttgaggc aaatattaaa gtaattttta tatgtctatt atttcattta aagaatatgc 1084
tgtgctaata atggagtgag acatgcttat tttgctaaag gatgcaccca aacttcaaac 1144
ttcaagcaaa tgaaatggac aatgcagata aagttgttat caacacgtcg ggagtatgtg 1204
tgttagaagc aattcctttt atttctttca cctttcataa gttgttatct agtcaatgta 1264
atgtatattg tattgaaatt tacagtgtgc aaaagtattt tacctttgca taagtgtttg 1324
ataaaaatga actgttctaa tatttatttt tatggcatct catttttcaa tacatgctct 1384
tttgattaaa gaaacttatt actgttgtca actgaattca cacacacaca aatatagtac 1444
catagaaaaa gtttgttttc tcgaaataat tcatctttca gcttctctgc ttttggtcaa 1504
tgtctaggaa atctcttcag aaataagaag ctatttcatt aagtgtgata taaacctcct 1564
caaacatttt acttagaggc aaggattgtc taatttcaat tgtgcaagac atgtgcctta 1624
taattatttt tagcttaaaa ttaaacagat tttgtaataa tgtaactttg ttaataggtg 1684
cataaacact aatgcagtca atttgaacaa aagaagtgac atacacaata taaatcatat 1744
gtcttcacac gttgcctata taatgagaag cagctctctg agggttctga aatcaatgtg 1804
gtccctctct tgcccactaa acaaagatgg ttgttcgggg tttgggattg acactggagg 1864
cagatagttg caaagttagt ctaaggtttc cctagctgta tttagcctct gactatatta 1924
gtatacaaag aggtcatgtg gttgagacca ggtgaatagt cactatcagt gtggagacaa 1984
gcacagcaca cagacatttt aggaaggaaa ggaactacga aatcgtgtga aaatgggttg 2044
gaacccatca gtgatcgcat attcattgat gagggtttgc ttgagataga aaatggtggc 2104
tcctttctgt cttatctcct agtttcttca atgcttacgc cttgttcttc tcaagagaaa 2164
gttgtaactc tctggtcttc atatgtccct gtgctccttt taaccaaata aagagttctt 2224
gtttctgaag aa                                                     2236

<210> 6
<211> 232
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 7
<211> 2133
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (206)...(916)

<400> 7
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
gaatacaaca agaagatggc catctgtaga ccaggaggtg gtccctcccc agaaactgga 120
tgggccagca cgttgattct gagcttctag cctccagaac tgccaaaagg tgtgttttgc 180
tgacttcaag catccctgct acaaa atg gcc tac ttc cat gaa ctg tcc agc   232
                            Met Ala Tyr Phe His Glu Leu Ser Ser
                             1               5
 
cga gtg agc ttt cag gag gca cgc ctg gct tgt gag agt gag gga gga   280
Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu Gly Gly
 10                  15                  20                  25
 
gtc ctc ctc agc ctt gag aat gaa gca gaa cag aag tta ata gag agc   328
Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile Glu Ser
                 30                  35                  40
 
atg ttg caa aac ctg aca aaa ccc ggg aca ggg att tct gat ggt gat   376
Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp Gly Asp
             45                  50                  55
 
ttc tgg ata ggg ctt tgg agg aat gga gat ggg caa aca tct ggt gcc   424
Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser Gly Ala
         60                  65                  70
 
tgc cca gat ctc tac cag tgg tct gat gga agc aat tcc cag tac cga   472
Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln Tyr Arg
     75                  80                  85
 
aac tgg tac aca gat gaa cct tcc tgc gga agt gaa aag tgt gtt gtg   520
Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys Val Val
 90                  95                 100                 105
 
atg tat cac caa cca act gcc aat cct ggc ctt ggg ggt ccc tac ctt   568
Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro Tyr Leu
                110                 115                 120
 
tac cag tgg aat gat gac agg tgt aac atg aag cac aat tat att tgc   616
Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr Ile Cys
            125                 130                 135
 
aag tat gaa cca gag att aat cca aca gcc cct gta gaa aag cct tat   664
Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys Pro Tyr
        140                 145                 150
 
ctt aca aat caa cca gga gac acc cat cag aat gtg gtt gtt act gaa   712
Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val Thr Glu
    155                 160                 165
 
gca gta aag gaa gaa caa aaa cta gtc caa acc agt cta cac tgt gga   760
Ala Val Lys Glu Glu Gln Lys Leu Val Gln Thr Ser Leu His Cys Gly
170                 175                 180                 185
 
ttt caa aga gta cca gaa aag aaa gtg gca tgg aag tat aat aac tca   808
Phe Gln Arg Val Pro Glu Lys Lys Val Ala Trp Lys Tyr Asn Asn Ser
                190                 195                 200
 
ttg act tgg ttc cag aat ttt gta att ctg gat ctg tat aag gaa tgg   856
Leu Thr Trp Phe Gln Asn Phe Val Ile Leu Asp Leu Tyr Lys Glu Trp
            205                 210                 215
 
cat cag aac aat agc ttg gaa tgg ctt gaa atc aca aag gat ctg caa   904
His Gln Asn Asn Ser Leu Glu Trp Leu Glu Ile Thr Lys Asp Leu Gln
        220                 225                 230
 
gat gaa ctg taa gctccccctt gaggcaaata ttaaagtaat ttttatatgt       956
Asp Glu Leu  *
    235
 
ctattatttc atttaaagaa tatgctgtgc taataatgga gtgagacatg cttattttgc 1016
taaaggatgc acccaaactt caaacttcaa gcaaatgaaa tggacaatgc agataaagtt 1076
gttatcaaca cgtcgggagt atgtgtgtta gaagcaattc cttttatttc tttcaccttt 1136
cataagttgt tatctagtca atgtaatgta tattgtattg aaatttacag tgtgcaaaag 1196
tattttacct ttgcataagt gtttgataaa aatgaactgt tctaatattt atttttatgg 1256
catctcattt ttcaatacat gctcttttga ttaaagaaac ttattactgt tgtcaactga 1316
attcacacac acacaaatat agtaccatag aaaaagtttg ttttctcgaa ataattcatc 1376
tttcagcttc tctgcttttg gtcaatgtct aggaaatctc ttcagaaata agaagctatt 1436
tcattaagtg tgatataaac ctcctcaaac attttactta gaggcaagga ttgtctaatt 1496
tcaattgtgc aagacatgtg ccttataatt atttttagct taaaattaaa cagattttgt 1556
aataatgtaa ctttgttaat aggtgcataa acactaatgc agtcaatttg aacaaaagaa 1616
gtgacataca caatataaat catatgtctt cacacgttgc ctatataatg agaagcagct 1676
ctctgagggt tctgaaatca atgtggtccc tctcttgccc actaaacaaa gatggttgtt 1736
cggggtttgg gattgacact ggaggcagat agttgcaaag ttagtctaag gtttccctag 1796
ctgtatttag cctctgacta tattagtata caaagaggtc atgtggttga gaccaggtga 1856
atagtcacta tcagtgtgga gacaagcaca gcacacagac attttaggaa ggaaaggaac 1916
tacgaaatcg tgtgaaaatg ggttggaacc catcagtgat cgcatattca ttgatgaggg 1976
tttgcttgag atagaaaatg gtggctcctt tctgtcttat ctcctagttt cttcaatgct 2036
tacgccttgt tcttctcaag agaaagttgt aactctctgg tcttcatatg tccctgtgct 2096
ccttttaacc aaataaagag ttcttgtttc tgaagaa                          2133

<210> 8
<211> 236
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 9
<211> 2033
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (106)...(816)

<400> 9
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
ggccaaaagg tgtgttttgc tgacttcaag catccctgct acaaa atg gcc tac ttc 117
                                                  Met Ala Tyr Phe
                                                   1
 
cat gaa ctg tcc agc cga gtg agc ttt cag gag gca cgc ctg gct tgt   165
His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys
 5                   10                  15                  20
 
gag agt gag gga gga gtc ctc ctc agc ctt gag aat gaa gca gaa cag   213
Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln
                 25                  30                  35
 
aag tta ata gag agc atg ttg caa aac ctg aca aaa ccc ggg aca ggg   261
Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly
             40                  45                  50
 
att tct gat ggt gat ttc tgg ata ggg ctt tgg agg aat gga gat ggg   309
Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly
         55                  60                  65
 
caa aca tct ggt gcc tgc cca gat ctc tac cag tgg tct gat gga agc   357
Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser
     70                  75                  80
 
aat tcc cag tac cga aac tgg tac aca gat gaa cct tcc tgc gga agt   405
Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser
 85                  90                  95                 100
 
gaa aag tgt gtt gtg atg tat cac caa cca act gcc aat cct ggc ctt   453
Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu
                105                 110                 115
 
ggg ggt ccc tac ctt tac cag tgg aat gat gac agg tgt aac atg aag   501
Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys
            120                 125                 130
 
cac aat tat att tgc aag tat gaa cca gag att aat cca aca gcc cct   549
His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro
        135                 140                 145
 
gta gaa aag cct tat ctt aca aat caa cca gga gac acc cat cag aat   597
Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn
    150                 155                 160
 
gtg gtt gtt act gaa gca gta aag gaa gaa caa aaa cta gtc caa acc   645
Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys Leu Val Gln Thr
165                 170                 175                 180
 
agt cta cac tgt gga ttt caa aga gta cca gaa aag aaa gtg gca tgg   693
Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys Lys Val Ala Trp
                185                 190                 195
 
aag tat aat aac tca ttg act tgg ttc cag aat ttt gta att ctg gat   741
Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe Val Ile Leu Asp
            200                 205                 210
 
ctg tat aag gaa tgg cat cag aac aat agc ttg gaa tgg ctt gaa atc   789
Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu Trp Leu Glu Ile
        215                 220                 225
 
aca aag gat ctg caa gat gaa ctg taa gctccccctt gaggcaaata         836
Thr Lys Asp Leu Gln Asp Glu Leu  *
    230                 235
 
ttaaagtaat ttttatatgt ctattatttc atttaaagaa tatgctgtgc taataatgga 896
gtgagacatg cttattttgc taaaggatgc acccaaactt caaacttcaa gcaaatgaaa 956
tggacaatgc agataaagtt gttatcaaca cgtcgggagt atgtgtgtta gaagcaattc 1016
cttttatttc tttcaccttt cataagttgt tatctagtca atgtaatgta tattgtattg 1076
aaatttacag tgtgcaaaag tattttacct ttgcataagt gtttgataaa aatgaactgt 1136
tctaatattt atttttatgg catctcattt ttcaatacat gctcttttga ttaaagaaac 1196
ttattactgt tgtcaactga attcacacac acacaaatat agtaccatag aaaaagtttg 1256
ttttctcgaa ataattcatc tttcagcttc tctgcttttg gtcaatgtct aggaaatctc 1316
ttcagaaata agaagctatt tcattaagtg tgatataaac ctcctcaaac attttactta 1376
gaggcaagga ttgtctaatt tcaattgtgc aagacatgtg ccttataatt atttttagct 1436
taaaattaaa cagattttgt aataatgtaa ctttgttaat aggtgcataa acactaatgc 1496
agtcaatttg aacaaaagaa gtgacataca caatataaat catatgtctt cacacgttgc 1556
ctatataatg agaagcagct ctctgagggt tctgaaatca atgtggtccc tctcttgccc 1616
actaaacaaa gatggttgtt cggggtttgg gattgacact ggaggcagat agttgcaaag 1676
ttagtctaag gtttccctag ctgtatttag cctctgacta tattagtata caaagaggtc 1736
atgtggttga gaccaggtga atagtcacta tcagtgtgga gacaagcaca gcacacagac 1796
attttaggaa ggaaaggaac tacgaaatcg tgtgaaaatg ggttggaacc catcagtgat 1856
cgcatattca ttgatgaggg tttgcttgag atagaaaatg gtggctcctt tctgtcttat 1916
ctcctagttt cttcaatgct tacgccttgt tcttctcaag agaaagttgt aactctctgg 1976
tcttcatatg tccctgtgct ccttttaacc aaataaagag ttcttgtttc tgaagaa    2033

<210> 10
<211> 236
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 11
<211> 649
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (39)...(648)

<400> 11
aatactttct gagagtcctg gacctcctgt gcaagaac atg aaa cac ctg tgg ttc 56
                                          Met Lys His Leu Trp Phe
                                           1               5
 
ttc ctc ctc ctg gtg gca gct ccc aga tgg gtc ctg tcc cag gtg cag   104
Phe Leu Leu Leu Val Ala Ala Pro Arg Trp Val Leu Ser Gln Val Gln
             10                  15                  20
 
ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag acc ctg tcc   152
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser
         25                  30                  35
 
ctc acc tgc act gtc tct ggt ggc tcc gtc agc agt ggt ggt tac tac   200
Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Gly Tyr Tyr
     40                  45                  50
 
tgg agc tgg atc cgg cag ccc cca ggg aag gga ctg gag tgg att ggg   248
Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly
 55                  60                  65                  70
 
tat atc tat tac agt ggg ggc acc aac tac aac ccc tcc ctc aag agt   296
Tyr Ile Tyr Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu Lys Ser
                 75                  80                  85
 
cga gtc acc ata tca gta gac acg tcc aag aac cag ttc tcc ctg aag   344
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys
             90                  95                 100
 
ctg acc tct gtg acc gct gcg gac acg gcc gtg tat tac tgt gcg aga   392
Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg
        105                 110                 115
 
gag tcg gga tat tgt act aat gtt gca tgc ttc cct gat gct ttt gat   440
Glu Ser Gly Tyr Cys Thr Asn Val Ala Cys Phe Pro Asp Ala Phe Asp
    120                 125                 130
 
atc tgg ggc caa ggg aca atg gtc acc gtg tct tca gcc tcc acc aag   488
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys
135                 140                 145                 150
 
ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg   536
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
                155                 160                 165
 
ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg   584
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
            170                 175                 180
 
gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc   632
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
        185                 190                 195
 
ttc cca gct gtc cta c a                                           649
Phe Pro Ala Val Leu
    200
 

<210> 12
<211> 203
<212> PRT
<213> Homo sapiens

<400> 12
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp
 1               5                  10                  15      
Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val
        35                  40                  45              
Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Gly Thr Asn Tyr
65                  70                  75                  80  
Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys
                85                  90                  95      
Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Glu Ser Gly Tyr Cys Thr Asn Val Ala Cys
        115                 120                 125             
Phe Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val
    130                 135                 140                 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
145                 150                 155                 160 
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                165                 170                 175     
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
            180                 185                 190         
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
        195                 200             


<210> 13
<211> 884
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (100)...(816)

<400> 13
caccgcggtg gcggccgctc tagcccgact ggagcacgag gacactgaca tggactgatg 60
gagtagaaag atcaggactc ctcagttcac cttctcaca atg agg ctc cct gct    114
                                           Met Arg Leu Pro Ala
                                            1               5
 
cag ctc ctg ggg ctg cta atg ctc tgg gtc cca gga tcc agt ggg gat   162
Gln Leu Leu Gly Leu Leu Met Leu Trp Val Pro Gly Ser Ser Gly Asp
                 10                  15                  20
 
gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc ctt gga cag   210
Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly Gln
             25                  30                  35
 
ccg gcc tcc atc tcc tgc agg tct agt caa agc ctc gta tac act gat   258
Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Thr Asp
         40                  45                  50
 
gga aac acc tcc ttg aat tgg ttt cag cag agg cca ggc caa tct cca   306
Gly Asn Thr Ser Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro
     55                  60                  65
 
agg cgc cta att tat aag gtt tct aac tgg gac tct ggg gtc cca gac   354
Arg Arg Leu Ile Tyr Lys Val Ser Asn Trp Asp Ser Gly Val Pro Asp
 70                  75                  80                  85
 
agc ttc agc ggc agt ggg tca ggc act gat ttc aca ctg aaa atc agc   402
Ser Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser
                 90                  95                 100
 
agg gtg gag gct gaa aat gtt ggg gtt tat tac tgc atg caa ggt aca   450
Arg Val Glu Ala Glu Asn Val Gly Val Tyr Tyr Cys Met Gln Gly Thr
            105                 110                 115
 
cac tgg cct ttc act ttc ggc gga ggg acc aag gtg gag atc aaa cga   498
His Trp Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
        120                 125                 130
 
act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag cag   546
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
    135                 140                 145
 
ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat   594
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
150                 155                 160                 165
 
ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg   642
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
                170                 175                 180
 
ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc acc   690
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
            185                 190                 195
 
tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag aaa   738
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
        200                 205                 210
 
cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc   786
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
    215                 220                 225
 
gtc aca aag agc ttc aac agg gga gag tgt tagagggcgg atcccccggg     836
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
230                 235
 
ctgcaggaat tcgatatcaa gcttatcgat accgtcgacc tcgagggg              884

<210> 14
<211> 239
<212> PRT
<213> Homo sapiens

<400> 14
Met Arg Leu Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Ser Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro
            20                  25                  30          
Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser
        35                  40                  45              
Leu Val Tyr Thr Asp Gly Asn Thr Ser Leu Asn Trp Phe Gln Gln Arg
    50                  55                  60                  
Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Trp Asp
65                  70                  75                  80  
Ser Gly Val Pro Asp Ser Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                85                  90                  95      
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asn Val Gly Val Tyr Tyr
            100                 105                 110         
Cys Met Gln Gly Thr His Trp Pro Phe Thr Phe Gly Gly Gly Thr Lys
        115                 120                 125             
Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro
    130                 135                 140                 
Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
145                 150                 155                 160 
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp
                165                 170                 175     
Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp
            180                 185                 190         
Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
        195                 200                 205             
Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln
    210                 215                 220                 
Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235                 


<210> 15
<211> 1016
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (178)...(899)

<400> 15
cacacaggaa acagctatga ccatgattac gccaagcgcg caattaaccc tcactaaagg 60
gaacaaaagc tggagctcca ccgcggtggc ggccgctcta gcccggctgg agcacgagga 120
cactgacacg gactgaagga gtagaaagag ctacaacagg caggcagggg cagcaag atg 180
                                                               Met
                                                                1
 
gtg ttg cag acc cag gtc ttc att tct ctg ttg ctc tgg atc tct ggt   228
Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly
             5                   10                  15
 
gcc aac ggg gac atc gtg atg acc cag tct cca gac tcc ctg gct gtg   276
Ala Asn Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val
         20                  25                  30
 
tct ctg ggc gag cgg gcc acc atc aac tgc aag tcc agc cag ggt gtt   324
Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Gly Val
     35                  40                  45
 
tta tac agc tcc aac aat aag aac tac tta gct tgg tac cag cag aaa   372
Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys
 50                  55                  60                  65
 
cca gga cag cca cct aag ctg ctc att tac tgg gca tct acc cgg gaa   420
Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu
                 70                  75                  80
 
tcc ggg gtc cct gac cga ttc agt ggc agc ggg tct ggg aca gat ttc   468
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
             85                  90                  95
 
act ctc acc atc agc agc ctg cag gct gaa gat gtg gca gtt tat ttc   516
Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe
        100                 105                 110
 
tgt cag caa tat tat gtt agt ccg ctc act ttc ggc gga ggg acc aag   564
Cys Gln Gln Tyr Tyr Val Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys
    115                 120                 125
 
gtg gag atc aaa cga act gtg gct gca cca tct gtc ttc atc ttc ccg   612
Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro
130                 135                 140                 145
 
cca tct gat gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg   660
Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
                150                 155                 160
 
ctg aat aac ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat   708
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp
            165                 170                 175
 
aac gcc ctc caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac   756
Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp
        180                 185                 190
 
agc aag gac agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa   804
Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
    195                 200                 205
 
gca gac tac gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag   852
Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln
210                 215                 220                 225
 
ggc ctg agc tcg ccc gtc aca aag agc ttc aac agg gga gag tgt ta    899
Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
                230                 235                 240
 
gagggcggat cccccgggct gcaggaattc gatatcaagc ttatcgatac cgtcgacctc 959
gagggggggc ccggtaccca attcgcccta tagtgagtcg tattacgcgc gctcact    1016

<210> 16
<211> 240
<212> PRT
<213> Homo sapiens

<400> 16
Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser
 1               5                  10                  15      
Gly Ala Asn Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala
            20                  25                  30          
Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Gly
        35                  40                  45              
Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln
    50                  55                  60                  
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg
65                  70                  75                  80  
Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                85                  90                  95      
Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr
            100                 105                 110         
Phe Cys Gln Gln Tyr Tyr Val Ser Pro Leu Thr Phe Gly Gly Gly Thr
        115                 120                 125             
Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe
    130                 135                 140                 
Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys
145                 150                 155                 160 
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
                165                 170                 175     
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln
            180                 185                 190         
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser
        195                 200                 205             
Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
    210                 215                 220                 
Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235                 240 


<210> 17
<211> 203
<212> PRT
<213> Homo sapiens

<400> 17
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp
 1               5                  10                  15      
Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val
        35                  40                  45              
Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Gly Thr Asn Tyr
65                  70                  75                  80  
Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys
                85                  90                  95      
Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Glu Ser Gly Tyr Cys Thr Asn Val Ala Cys
        115                 120                 125             
Phe Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val
    130                 135                 140                 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
145                 150                 155                 160 
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                165                 170                 175     
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
            180                 185                 190         
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
        195                 200             


<210> 18
<211> 239
<212> PRT
<213> Homo sapiens

<400> 18
Met Arg Leu Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Ser Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro
            20                  25                  30          
Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser
        35                  40                  45              
Leu Val Tyr Thr Asp Gly Asn Thr Ser Leu Asn Trp Phe Gln Gln Arg
    50                  55                  60                  
Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Trp Asp
65                  70                  75                  80  
Ser Gly Val Pro Asp Ser Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                85                  90                  95      
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asn Val Gly Val Tyr Tyr
            100                 105                 110         
Cys Met Gln Gly Thr His Trp Pro Phe Thr Phe Gly Gly Gly Thr Lys
        115                 120                 125             
Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro
    130                 135                 140                 
Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
145                 150                 155                 160 
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp
                165                 170                 175     
Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp
            180                 185                 190         
Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
        195                 200                 205             
Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln
    210                 215                 220                 
Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235                 


<210> 19
<211> 240
<212> PRT
<213> Homo sapiens

<400> 19
Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser
 1               5                  10                  15      
Gly Ala Asn Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala
            20                  25                  30          
Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Gly
        35                  40                  45              
Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln
    50                  55                  60                  
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg
65                  70                  75                  80  
Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                85                  90                  95      
Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr
            100                 105                 110         
Phe Cys Gln Gln Tyr Tyr Val Ser Pro Leu Thr Phe Gly Gly Gly Thr
        115                 120                 125             
Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe
    130                 135                 140                 
Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys
145                 150                 155                 160 
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
                165                 170                 175     
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln
            180                 185                 190         
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser
        195                 200                 205             
Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
    210                 215                 220                 
Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235                 240 

