                         SEQUENCE LISTING

  
<110>  Wyeth
 
<120>  Humanized Anti-RAGE Antibody

<130>  Docket No. AM103209

<150>  US 61/088,273
<151>  August 12, 2008

<160>  81    

<170>  PatentIn version 3.4

<210>  1
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized Anti-RAGE Variable Region

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  2
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized Anti-RAGE Variable Region

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 10H6

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Gly Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asn Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Thr Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Glu 
225                 230                 235                 240 


Ser Ser 
        


<210>  4
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 8G9

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ser Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Thr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  5
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 10D8

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Phe Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Asn Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Glu Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  6
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 3B3

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Phe Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Thr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  7
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  Rage RD 1G6

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Phe Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Asn Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  8
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 2E6

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Asn Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Val Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Asn Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  9
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 5A3

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ile Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Ser Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Lys Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Thr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  10
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 10G10

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Glu Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  11
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 5H3

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Asp Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Leu Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  12
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 10H6

<400>  12
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cggagtgacc     60

atcacctgtc aggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa gaatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccac cggcctcgac tactggggcc agggcaccct ggtgaccgag    720

tcctct                                                               726


<210>  13
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 8G9

<400>  13
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcagctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccac cggcatcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  14
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 10D8

<400>  14
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga caaagtgacc     60

atcacctgtc gggcctcaca ggatgtgggc ttctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggca atggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggtgaac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccac cggcttcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  15
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 3B3

<400>  15
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc ttctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaagatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccac cggcatcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  16
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 1G6

<400>  16
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc ttctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

gggacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccaa cggcttcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  17
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 2E6

<400>  17
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgcc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaaactctg aggtgcagct ggtggagtct ggcgtcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctcaggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccaa cggcctcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  18
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 5A3

<400>  18
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga catagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tagcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgaac atcctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tcaagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtacc    660

agaggcggcg atatcaccac cggcatcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  19
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 10G10

<400>  19
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaggg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gagctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgagaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccac cggcttcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  20
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE RD 5H3

<400>  20
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatcgaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg ttgagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggttctact ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gttgcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccac cggcttcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  21
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R3A2 PDM4H12 1A6

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Leu Val Ser Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  22
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R3A1 PDM4H12 1B2

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Leu Val Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  23
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R3A1 PDM4H12 1B4

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Arg Glu Gly Leu Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  24
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R3A1 PDM4H12 1D2

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Arg Val Ser Leu Asp His Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  25
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R3A1 PDM4H12 1G5

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Leu Asp Ser Leu Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  26
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1B2

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Arg Val Gly Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  27
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1B6

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Ile Ile Ser Leu Asp Trp Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  28
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1C2

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Lys Val Ser Leu Asp Arg Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  29
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1C3

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Leu Gly Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  30
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1G4

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Leu Asp Ser Leu His Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  31
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R3A2 PDM4H12 1A6

<400>  31
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcttggt gtccttggac gtgtggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  32
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R3A1 PDM4H12 1B2

<400>  32
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcctcgt ggggctcgac tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  33
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R3A1 PDM4H12 1B4

<400>  33
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatccggga ggggctcagg tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  34
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R3A1 PDM4H12 1D2

<400>  34
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatccgcgt gtcgttggac cactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  35
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R3A1 PDM4H12 1G5

<400>  35
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcttgga cagcttgccc tactggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  36
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1B2

<400>  36
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatccgggt ggggttggac gtgtggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  37
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1B6

<400>  37
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcatcat ctccttggac tggtggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  38
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1C2

<400>  38
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaaggt ctccttggac aggtggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  39
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1C3

<400>  39
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcaccct cggcttggac gtctggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  40
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  RAGE S1R6A1 PDM4H12 1G4

<400>  40
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctctca ggatgtgggc atctacgtga actggtttca gcagaagcct    120

ggcaaggctc ccaggcgcct gatctaccgg gccaccaacc tggccgatgg cgtgccttcc    180

agattctccg gctctcgctc tggcaccgat ttcaccctga ccatctcctc cctccagcct    240

gaggatttcg ccacctacta ctgcctggag ttcgacgagc accctctgac ctttggcggc    300

ggaacaaagg tggagatcaa ggatggcggt ggatcgggcg gtggtggatc tggaggaggt    360

ggaagctctg aggtgcagct ggtggagtct ggcggcggac tggtgcagcc tggcggctct    420

ctgagactgt cttgtgccgc ctccggcttc accttcaaca actactggat gacctgggtg    480

aggcaggccc ctggcaaggg cctggagtgg gtggcctcca tcgacaactc cggcgacaac    540

acctactacc ccgactccgt gaaggaccgg ttcaccatct ccagggacaa cgccaagaac    600

tccctgtacc tccagatgaa ctccctgagg gccgaggata ccgccgtgta ctactgtgcc    660

agaggcggcg atatcctgga ctcgttgcac ttctggggcc agggcaccct ggtgaccgtg    720

tcctct                                                               726


<210>  41
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Flexible Linker

<400>  41

Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
1               5                   10                  15      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Invariant CDR1-Kappa sequences


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Xaa Ala Ser Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  43
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Invariant CDR3-Kappa


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Xaa Glu Xaa Xaa Xaa Xaa Pro Xaa Xaa 
1               5                   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Invariant CDR2-H chain sequences


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  45
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Invariant CDR3-H chain sequences


<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Gly Gly Asp Ile Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  46
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR-1 Kappa Variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Arg or Gln or Leu

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Ile or Phe or His or Ser or Thr or Val or Asn or Tyr or Trp or 
       His

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Xaa Ala Ser Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  47
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2-H


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Asp or Glu

<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  48
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3-H


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Leu or Ile or Arg or Lys or Thr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Thr or Asn or Leu or Ile or Val or Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Phe or Leu or Ile or Met or Val

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Asp or Arg or Pro or His

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Tyr or Val or His or Trp or Arg or Phe

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Gly Gly Asp Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  49
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Flexible Linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Gly or Asn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Ser or Asn

<400>  49

Xaa Gly Gly Gly Ser Gly Xaa Gly Gly Ser Gly Gly Gly Gly Xaa Ser 
1               5                   10                  15      


<210>  50
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  10H6 VH

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Thr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Glu Ser Ser 
        115                 


<210>  51
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  8G9 VH

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ser 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Thr Gly Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  10D8 VH

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Glu Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  3B3 VH

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Thr Gly Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  1G6 VH

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Asn Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  55
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  2EG VH

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Val Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Asn Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  56
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  5A3 VH

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Lys Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Asp Ile Thr Thr Gly Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  57
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  10G10 VH

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Glu Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  5H3 VH

<400>  58

Glu Val Leu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  59
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  3A6 VH

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Leu Val Ser Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  60
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  3B2 VH

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Leu Val Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  61
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  3B4 VH

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Arg Glu Gly Leu Arg Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  62
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  3D2 VH

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Arg Val Ser Leu Asp His Ile Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  63
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  3G5 VH

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Leu Asp Ser Leu Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  64
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6B2 VH

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Arg Val Gly Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  65
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6B6 VH

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Ile Ile Ser Leu Asp Trp Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  66
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6C2 VH

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Lys Val Ser Leu Asp Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6C3 VH

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Thr Leu Gly Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  68
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6G4 VH

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asp Asn Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Leu Asp Ser Leu His Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 10H6 VL

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Gly Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 10D8 VL

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Phe Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  71
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 3B3 VL

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Phe Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  72
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 5A3 VL

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ile Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Ser Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  73
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 10G10 VL

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 
            100                 105         


<210>  74
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE RD 5H3 VL

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Asp Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  75
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  Parental (VL 2.11,VH V2.0) scFv

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Gly Ile Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Glu Phe Asp Glu His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Asp Asn 
                165                 170                 175     


Ser Gly Asp Asn Thr Tyr Tyr Pro Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp 
    210                 215                 220                 


Ile Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  76
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  xaa= Gln or Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  xaa= Ile or Phe

<400>  76

Xaa Ala Ser Gln Asp Val Gly Xaa Tyr Val Asn 
1               5                   10      


<210>  77
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL-2

<400>  77

Arg Ala Thr Asn Leu Ala Asp 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL-3

<400>  78

Leu Glu Phe Asp Glu His Pro Leu Thr 
1               5                   


<210>  79
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH-1


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  xaa= Thr or Ser

<400>  79

Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr 
1               5                   10  


<210>  80
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CFDRH-2


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  xaa= Asp or Glu

<400>  80

Ser Ile Asp Asn Ser Gly Xaa Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  81
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH-3


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa= Leu or Thr or Lys or Ile or Arg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa= Asp or Leu or Val or Ser or Glu or Thr or Ile or Asn

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa= Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa= Phe or Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa= Asp or Arg or Pro or His

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa= Tyr or Val or His or Trp or Arg or Phe

<400>  81

Gly Gly Asp Ile Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


