                         SEQUENCE LISTING

<110>  MedImmune LLC
       Chowdhury, Partha S.
       Bowden, Emma T.
       Bruckheimer, Elizabeth
       Coats, Steve
       Kiener, Peter
       Wu, Herren
 
<120>  Anti-Ephrin B2 Antibodies and Their Use in Treatment of Disease

<130>  BF401PCT

<150>  US 61/088,228
<151>  2008-08-12

<160>  40    

<170>  PatentIn version 3.3

<210>  1
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  1
caagacatcc agatgaccca gtctccactc tccctgtccg tcacccctgg agagccggcc     60

tccatctcct gcaggtctag tcagagcctc ctccatggta atggatacaa ctatttcgat    120

tggtacctgc agaagccagg gcaatctcca cagctcctga tctatttggg ttctactcgg    180

gcctccgggg tccctgacag gttcagtggc agtggatcag ggacagattt tacattgaaa    240

atcagcagag tggaggctga cgatgttggg gtttattact gcatgcaagc tctacaaacc    300

cccttcactt tcggcggagg gaccaaggtg gagatcaaac ga                       342


<210>  2
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His 
            20                  25                  30          


Gly Asn Gly Tyr Asn Tyr Phe Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu Gln Thr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  3
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  3
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct atgtaccata tgttttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctctcctt ctggtggcgt tacttggtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc cagagatctc    300

tatggttcgg ggctcgacta ctggggccag ggaaccctgg tcaccgtctc aagc          354


<210>  4
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Met Tyr 
            20                  25                  30          


His Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Gly Gly Val Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Gly Ser Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  5
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  5
caagacatcc agatgaccca gtctccactc tccctgcccg tcacccctgg agagccggcc     60

tccatctcct gcaggtctag tcagagcctc ctgcatagta atggatacaa ctatttggat    120

tggtacctgc agaagccagg gcagtctcca cagctcctga tctatttggg ttctaatcgg    180

gcctccgggg tccctgacag gttcagtggc agtggatcag gcacagattt tacactgaaa    240

atcagcagag tggaggctga ggatgttggg gtttattact gcatgcaagc tctacaaact    300

cctcccactt tcggcggagg gaccaaggtg gagatcaaac ga                       342


<210>  6
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His 
            20                  25                  30          


Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu Gln Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  7
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  7
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct tggtacacta tgatttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttat atccgttctt ctggtggcaa gacttcttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagtaata    300

actggaacga gagcttttga tatgtggggc caaggcacaa tggtcaccgt ctcaagc       357


<210>  8
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Thr Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Arg Ser Ser Gly Gly Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ile Thr Gly Thr Arg Ala Phe Asp Met Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  9
caggacatcg tcatgactca aacccctcct agtttaccgg ttaacccggg tgaacctgcc     60

tccatctcct gcaggtctag tcagagcctt ctgcatagta atggatacaa ctatttggat    120

tggtacctgc agaggccagg gcagtctcca cagctcctga tctatttggg ttctaatcgg    180

gcctccgggg tccctgacag gttcagtggc agtggatcag gcacagattt tacactgaaa    240

atcagcagag tggaggctga ggatgttggg gtttattact gcatgcaacc tctacaaact    300

cctatcacct tcggccaagg gacacgactg gagattaaag ga                       342


<210>  10
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His 
            20                  25                  30          


Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Pro Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys Gly 
        


<210>  11
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  11
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct cgttaccata tgtcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atcggtcctt ctggtggcgg tactttttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagaacccgt    300

gtggtggttg gcgcttttga tatctggggc caagggacaa tggtcaccgt ctcaagc       357


<210>  12
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Pro Ser Gly Gly Gly Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Arg Val Val Val Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  13
caagacatcc agatgaccca gtctccactc tccctgcccg tcacccctgg agagccggcc     60

tccatctcct gcaggtctag tcagagcctc ctgcataata atggatacaa ctatttggat    120

tggtacctgc agaagccagg gcggtctcca caactcctga tctttttggg ttctactcgg    180

gcctccgggg tccctgacag gttcagtggc agtggatcag gcacagattt tacactgaga    240

atcagcagag tggaggctga ggatgttgga gtttactact gcatgcaagc tctacacgcc    300

cccaccttcg gccaagggac acgactggag attagacga                           339


<210>  14
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His 
            20                  25                  30          


Asn Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Arg 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Phe Leu Gly Ser Thr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu His Ala Pro Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Arg 
            100                 105                 110         


Arg 
    


<210>  15
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  15
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct aattacatta tgttttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctggt atcgttcctt ctggtggcgg tactttttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagactac    300

ggttcgggga tggacctctg gggccagggg accacggtca ccgtctcaag c             351


<210>  16
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ile Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Val Pro Ser Gly Gly Gly Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Ser Gly Met Asp Leu Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Ser Ser Gln Ser Leu Leu His Gly Asn Gly Tyr Asn Tyr Phe Asp 
1               5                   10                  15      


<210>  18
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  18

Leu Gly Ser Thr Arg Ala Ser 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gln Ala Leu Gln Thr Pro Phe Thr 
1               5                   


<210>  20
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Tyr His Met Phe 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Ile Ser Pro Ser Gly Gly Val Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Leu Tyr Gly Ser Gly Leu Asp Tyr 
1               5                   


<210>  23
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  24
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gln Ala Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  26
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  26

Trp Tyr Thr Met Ile 
1               5   


<210>  27
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  27

Tyr Ile Arg Ser Ser Gly Gly Lys Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

Val Ile Thr Gly Thr Arg Ala Phe Asp Met 
1               5                   10  


<210>  29
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  30
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gln Pro Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  32
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg Tyr His Met Ser 
1               5   


<210>  33
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Ile Gly Pro Ser Gly Gly Gly Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  34

Thr Arg Val Val Val Gly Ala Phe Asp Ile 
1               5                   10  


<210>  35
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg Ser Ser Gln Ser Leu Leu His Asn Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

Leu Gly Ser Thr Arg Ala Ser 
1               5           


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gln Ala Leu His Ala Pro Thr 
1               5               


<210>  38
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  38

Asn Tyr Ile Met Phe 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Ile Val Pro Ser Gly Gly Gly Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Tyr Gly Ser Gly Met Asp Leu 
1               5               


