                         SEQUENCE LISTING

<110>  Roizman, et al.
 
<120>  Attenuated herpesviruses encoding a MEK pathway polypeptide

<130>  27373/44154A

<140>  US-61/087,909
<141>  2008-08-11

<160>  24    

<170>  PatentIn version 3.3

<210>  1
<211>  2222
<212>  DNA
<213>  Homo sapiens

<400>  1
attcggcacg agggaggaag cgagaggtgc tgccctcccc ccggagttgg aagcgcgtta     60

cccgggtcca aaatgcccaa gaagaagccg acgcccatcc agctgaaccc ggcccccgac    120

ggctctgcag ttaacgggac cagctctgcg gagaccaact tggaggcctt gcagaagaag    180

ctggaggagc tagagcttga tgagcagcag cgaaagcgcc ttgaggcctt tcttacccag    240

aagcagaagg tgggagaact gaaggatgac gactttgaga agatcagtga gctgggggct    300

ggcaatggcg gtgtggtgtt caaggtctcc cacaagcctt ctggcctggt catggccaga    360

aagctaattc atctggagat caaacccgca atccggaacc agatcataag ggagctgcag    420

gttctgcatg agtgcaactc tccgtacatc gtgggcttct atggtgcgtt ctacagcgat    480

ggcgagatca gtatctgcat ggagcacatg gatggaggtt ctctggatca agtcctgaag    540

aaagctggaa gaattcctga acaaatttta ggaaaagtta gcattgctgt aataaaaggc    600

ctgacatatc tgagggagaa gcacaagatc atgcacagag atgtcaagcc ctccaacatc    660

ctagtcaact cccgtgggga gatcaagctc tgtgactttg gggtcagcgg gcagctcatc    720

gactccatgg ccaactcctt cgtgggcaca aggtcctaca tgtcgccaga aagactccag    780

gggactcatt actctgtgca gtcagacatc tggagcatgg gactgtctct ggtagagatg    840

gcggttggga ggtatcccat ccctcctcca gatgccaagg agctggagct gatgtttggg    900

tgccaggtgg aaggagatgc ggctgagacc ccacccaggc caaggacccc cgggaggccc    960

cttagctcat acggaatgga cagccgacct cccatggcaa tttttgagtt gttggattac   1020

atagtcaacg agcctcctcc aaaactgccc agtggagtgt tcagtctgga atttcaagat   1080

tttgtgaata aatgcttaat aaaaaacccc gcagagagag cagatttgaa gcaactcatg   1140

gttcatgctt ttatcaagag atctgatgct gaggaagtgg attttgcagg ttggctctgc   1200

tccaccatcg gccttaacca gcccagcaca ccaacccatg ctgctggcgt ctaagtgttt   1260

gggaagcaac aaagagcgag tcccctgccc ggtggtttgc catgtcgctt ttgggcctcc   1320

ttcccatgcc tgtctctgtt cagatgtgca tttcacctgt gacaaaggat gaagaacaca   1380

gcatgtgcca agattctact cttgtcattt ttaatattac tgtctttatt cttattacta   1440

ttattgttcc cctaagtgga ttggctttgt gcttggggct atttgtgtgt atgctgatga   1500

tcaaaacctg tgccaggctg aattacagtg aaatttttgg tgaatgtggg tagtcattct   1560

tacaattgca ctgctgttcc tgctccatga ctggctgtct gcctgtattt tcggactttg   1620

acatttgaca tttggtggac tttatcttgc tgggcatact ttctctctag gagggagcct   1680

tgtgagatcc ttcacaggca gtgcatgtga agcatgcttt gctgctatga aaatgagcat   1740

cagagagtgt acatcatgtt attttattat tattatttgc ttttcatgta gaactcagca   1800

gttgacatcc aaatctagcc agagcccttc actgccatga tagctggggc ttcaccagtc   1860

tgtctactgt ggtgatctgt agacttctgg ttgtatttct atatttattt tcagtatact   1920

gtgtgggata cttagtggta tgtctcttta agttttgatt aatgtttctt aaatggaatt   1980

atttgaatgt cacaaattga tcaagatatt aaaatgtcgg atttatcttt ccccatatcc   2040

aagtaccaat gctgttgtaa acaacgtgta tagtgcctaa aattgtatga aaatcctttt   2100

aaccatttta acctagatgt ttaacaaatc taatctctta ttctaataaa tatactatga   2160

aataaaaaaa aaaggagaaa gctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2220

aa                                                                  2222


<210>  2
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp 
1               5                   10                  15      


Gly Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala 
            20                  25                  30          


Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys 
        35                  40                  45              


Arg Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys 
    50                  55                  60                  


Asp Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly 
65                  70                  75                  80  


Val Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg 
                85                  90                  95      


Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile 
            100                 105                 110         


Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly 
        115                 120                 125             


Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu 
    130                 135                 140                 


His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg 
145                 150                 155                 160 


Ile Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly 
                165                 170                 175     


Leu Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp 
        195                 200                 205             


Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val 
    210                 215                 220                 


Gly Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr 
225                 230                 235                 240 


Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met 
                245                 250                 255     


Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu 
            260                 265                 270         


Leu Met Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro 
        275                 280                 285             


Arg Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser 
    290                 295                 300                 


Arg Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu 
305                 310                 315                 320 


Pro Pro Pro Lys Leu Pro Ser Gly Val Phe Ser Leu Glu Phe Gln Asp 
                325                 330                 335     


Phe Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu 
            340                 345                 350         


Lys Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu 
        355                 360                 365             


Val Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro 
    370                 375                 380                 


Ser Thr Pro Thr His Ala Ala Gly Val 
385                 390             


<210>  3
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  3
acataatttc tggagccctg taccaacgtg tggccacata ttctgtcagg aaccctgtgt     60

gatcatggtc tggatctgca acacgggcca ggccaaagtc acagatcttg agatcacagg    120

tggtgttgag cagcaggcag gcaggcaatc ggtccgagtg gctgtcggct cttcagctct    180

ccgctcggcg tcttccttcc tctcccggtc agcgtcggcg gctgcaccgg cggcgggcag    240

tcctgcggga ggggcgacaa gagctgaggc gcggccgccg agcgtcgagc tcagcgcggc    300

ggaggcggcg gcggcccggc agccaacatg gcggcggcgg cggcggcggg cgcgggcccg    360

gagatggtcc gcgggcaggt gttcgacgtg gggccgcgct acaccaacct ctcgtacatc    420

ggcgagggcg cctacggcat ggtgtgctct gcttatgata atgtcaacaa agttcgagta    480

gctatcaaga aaatcagccc ctttgagcac cagacctact gccagagaac cctgagggag    540

ataaaaatct tactgcgctt cagacatgag aacatcattg gaatcaatga cattattcga    600

gcaccaacca tcgagcaaat gaaagatgta tatatagtac aggacctcat ggaaacagat    660

ctttacaagc tcttgaagac acaacacctc agcaatgacc atatctgcta ttttctctac    720

cagatcctca gagggttaaa atatatccat tcagctaacg ttctgcaccg tgacctcaag    780

ccttccaacc tgctgctcaa caccacctgt gatctcaaga tctgtgactt tggcctggcc    840

cgtgttgcag atccagacca tgatcacaca gggttcctga cagaatatgt ggccacacgt    900

tggtacaggg ctccagaaat tatgttgaat tccaagggct acaccaagtc cattgatatt    960

tggtctgtag gctgcattct ggcagaaatg ctttccaaca ggcccatctt tccagggaag   1020

cattatcttg accagctgaa tcacattttg ggtattcttg gatccccatc acaagaagac   1080

ctgaattgta taataaattt aaaagctagg aactatttgc tttctcttcc acacaaaaat   1140

aaggtgccat ggaacaggct gttcccaaat gctgactcca aagctctgga cttattggac   1200

aaaatgttga cattcaaccc acacaagagg attgaagtag aacaggctct ggcccaccca   1260

tatctggagc agtattacga cccgagtgac gagcccatcg ccgaagcacc attcaagttc   1320

gacatggaat tggatgactt gcctaaggaa aagctaaaag aactaatttt tgaagagact   1380

gctagattcc agccaggata cagatcttaa atttgtcagg acaagggctc agaggactgg   1440

acgtgctcag acatcggtgt tcttcttccc agttcttgac ccctggtcct gtctccagcc   1500

cgtcttggct tatccacttt gactcctttg agccgtttgg aggggcggtt tctggtagtt   1560

gtggctttta tgctttcaaa gaatttcttc agtccagaga attcactggc c            1611


<210>  4
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  5
<211>  1759
<212>  DNA
<213>  Homo sapiens

<400>  5
cccctgcctc tcggactcgg gctgcggcgt cagccttctt cgggcctcgg cagcggtagc     60

ggctcgctcg cctcagcccc agcgcccctc ggctaccctc ggcccaggcc cgcagcgccg    120

cccgccctcg gccgccccga cgccggcctg ggccgcggcc gcagccccgg gctcgcgtag    180

gcgccgaccg ctcccggccc gccccctatg ggccccggct agaggcgccg ccgccgccgg    240

cccgcggagc cccgatgctg gcccggagga agccggtgct gccggcgctc accatcaacc    300

ctaccatcgc cgagggccca tcccctacca gcgagggcgc ctccgaggca aacctggtgg    360

acctgcagaa gaagctggag gagctggaac ttgacgagca gcagaagaag cggctggaag    420

cctttctcac ccagaaagcc aaggtcggcg aactcaaaga cgatgacttc gaaaggatct    480

cagagctggg cgcgggcaac ggcggggtgg tcaccaaagt ccagcacaga ccctcgggcc    540

tcatcatggc caggaagctg atccaccttg agatcaagcc ggccatccgg aaccagatca    600

tccgcgagct gcaggtcctg cacgaatgca actcgccgta catcgtgggc ttctacgggg    660

ccttctacag tgacggggag atcagcattt gcatggaaca catggacggc ggctccctgg    720

accaggtgct gaaagaggcc aagaggattc ccgaggagat cctggggaaa gtcagcatcg    780

cggttctccg gggcttggcg tacctccgag agaagcacca gatcatgcac cgagatgtga    840

agccctccaa catcctcgtg aactctagag gggagatcaa gctgtgtgac ttcggggtga    900

gcggccagct catagactcc atggccaact ccttcgtggg cacgcgctcc tacatggctc    960

cggagcggtt gcagggcaca cattactcgg tgcagtcgga catctggagc atgggcctgt   1020

ccctggtgga gctggccgtc ggaaggtacc ccatcccccc gcccgacgcc aaagagctgg   1080

aggccatctt tggccggccc gtggtcgacg gggaagaagg agagcctcac agcatctcgc   1140

ctcggccgag gccccccggg cgccccgtca gcggtcacgg gatggatagc cggcctgcca   1200

tggccatctt tgaactcctg gactatattg tgaacgagcc acctcctaag ctgcccaacg   1260

gtgtgttcac ccccgacttc caggagtttg tcaataaatg cctcatcaag aacccagcgg   1320

agcgggcgga cctgaagatg ctcacaaacc acaccttcat caagcggtcc gaggtggaag   1380

aagtggattt tgccggctgg ttgtgtaaaa ccctgcggct gaaccagccc ggcacaccca   1440

cgcgcaccgc cgtgtgacag tggccgggct ccctgcgtcc cgctggtgac ctgcccaccg   1500

tccctgtcca tgccccgccc ttccagctga ggacaggctg gcgcctccac ccaccctcct   1560

gcctcacccc tgcggagagc accgtggcgg ggcgacagcg catgcaggaa cgggggtctc   1620

ctctcctgcc cgtcctggcc ggggtgcctc tggggacggg cgacgctgct gtgtgtggtc   1680

tcagaggctc tgcttcctta ggttacaaaa caaaacaggg agagaaaaag caaaaaaaaa   1740

aaaaaaaaaa aaaaaaaaa                                                1759


<210>  6
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Ala Arg Arg Lys Pro Val Leu Pro Ala Leu Thr Ile Asn Pro 
1               5                   10                  15      


Thr Ile Ala Glu Gly Pro Ser Pro Thr Ser Glu Gly Ala Ser Glu Ala 
            20                  25                  30          


Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu 
        35                  40                  45              


Gln Gln Lys Lys Arg Leu Glu Ala Phe Leu Thr Gln Lys Ala Lys Val 
    50                  55                  60                  


Gly Glu Leu Lys Asp Asp Asp Phe Glu Arg Ile Ser Glu Leu Gly Ala 
65                  70                  75                  80  


Gly Asn Gly Gly Val Val Thr Lys Val Gln His Arg Pro Ser Gly Leu 
                85                  90                  95      


Ile Met Ala Arg Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg 
            100                 105                 110         


Asn Gln Ile Ile Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro 
        115                 120                 125             


Tyr Ile Val Gly Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser 
    130                 135                 140                 


Ile Cys Met Glu His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys 
145                 150                 155                 160 


Glu Ala Lys Arg Ile Pro Glu Glu Ile Leu Gly Lys Val Ser Ile Ala 
                165                 170                 175     


Val Leu Arg Gly Leu Ala Tyr Leu Arg Glu Lys His Gln Ile Met His 
            180                 185                 190         


Arg Asp Val Lys Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile 
        195                 200                 205             


Lys Leu Cys Asp Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala 
    210                 215                 220                 


Asn Ser Phe Val Gly Thr Arg Ser Tyr Met Ala Pro Glu Arg Leu Gln 
225                 230                 235                 240 


Gly Thr His Tyr Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser 
                245                 250                 255     


Leu Val Glu Leu Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala 
            260                 265                 270         


Lys Glu Leu Glu Ala Ile Phe Gly Arg Pro Val Val Asp Gly Glu Glu 
        275                 280                 285             


Gly Glu Pro His Ser Ile Ser Pro Arg Pro Arg Pro Pro Gly Arg Pro 
    290                 295                 300                 


Val Ser Gly His Gly Met Asp Ser Arg Pro Ala Met Ala Ile Phe Glu 
305                 310                 315                 320 


Leu Leu Asp Tyr Ile Val Asn Glu Pro Pro Pro Lys Leu Pro Asn Gly 
                325                 330                 335     


Val Phe Thr Pro Asp Phe Gln Glu Phe Val Asn Lys Cys Leu Ile Lys 
            340                 345                 350         


Asn Pro Ala Glu Arg Ala Asp Leu Lys Met Leu Thr Asn His Thr Phe 
        355                 360                 365             


Ile Lys Arg Ser Glu Val Glu Glu Val Asp Phe Ala Gly Trp Leu Cys 
    370                 375                 380                 


Lys Thr Leu Arg Leu Asn Gln Pro Gly Thr Pro Thr Arg Thr Ala Val 
385                 390                 395                 400 


<210>  7
<211>  1963
<212>  DNA
<213>  Homo sapiens

<400>  7
gaaacgtccc gtgtgggagg ggcgggtctg ggtgcggctg ccgcatgact cgtggttcgg     60

aggcccacgt ggccggggcg gggactcagg cgcctggcag ccgactgatt acgtagcggg    120

cggggccgga agtgccgctc cttggtgggg gctgttcatg gcggttccgg ggtctccaac    180

atttttcccg gtctgtggtc ctaaatctgt ccaaagcaga ggcagtggag cttgaggttc    240

ttgctggtgt gaaatgactg agtacaaact ggtggtggtt ggagcaggtg gtgttgggaa    300

aagcgcactg acaatccagc taatccagaa ccactttgta gatgaatatg atcccaccat    360

agaggattct tacagaaaac aagtggttat agatggtgaa acctgtttgt tggacatact    420

ggatacagct ggacaagaag agtacagtgc catgagagac caatacatga ggacaggcga    480

aggcttcctc tgtgtatttg ccatcaataa tagcaagtca tttgcggata ttaacctcta    540

cagggagcag attaagcgag taaaagactc ggatgatgta cctatggtgc tagtgggaaa    600

caagtgtgat ttgccaacaa ggacagttga tacaaaacaa gcccacgaac tggccaagag    660

ttacgggatt ccattcattg aaacctcagc caagaccaga cagggtgttg aagatgcttt    720

ttacacactg gtaagagaaa tacgccagta ccgaatgaaa aaactcaaca gcagtgatga    780

tgggactcag ggttgtatgg gattgccatg tgtggtgatg taacaagata cttttaaagt    840

tttgtcagaa aagagccact ttcaagctgc actgacaccc tggtcctgac ttcctggagg    900

agaagtattc ctgttgctgt cttcagtctc acagagaagc tcctgctact tccccagctc    960

tcagtagttt agtacaataa tctctatttg agaagttctc agaataacta cctcctcact   1020

tggctgtctg accagagaat gcacctcttg ttactccctg ttatttttct gccctgggtt   1080

cttccacagc acaaacacac ctcaacacac ctctgccacc ccaggttttt catctgaaaa   1140

gcagttcatg tctgaaacag agaaccaaac cgcaaacgtg aaattctatt gaaaacagtg   1200

tcttgagctc taaagtagca actgctggtg attttttttt tctttttact gttgaactta   1260

gaactatgcc taatttttgg agaaatgtca taaattactg ttttgccaag aatatagtta   1320

ttattgctgt ttggtttgtt tataatgtta tcggctctat tctctaaact ggcatctgct   1380

ctagattcat aaatacaaaa atgaatactg aattttgagt ctatcctagt cttcacaact   1440

ttgacgtaat taaatccaac ttttcacagt gaagtgcctt tttcctagaa gtggtttgta   1500

gactccttta taatatttca gtggaataga tgtctcaaaa atccttatgc atgaaatgaa   1560

tgtctgagat acgtctgtga cttatctacc attgaaggaa agctatatct atttgagagc   1620

agatgccatt ttgtacatgt atgaaattgg ttttccagag gcctgttttg gggctttccc   1680

aggagaaaga tgaaactgaa agcatatgaa taatttcact taataatttt tacctaatct   1740

ccactttttt cataggttac tacctataca atgtatgtaa tttgtttccc ctagcttact   1800

gataaaccta atattcaatg aacttccatt tgtattcaaa tttgtgtcat accagaaagc   1860

tctacatttg cagatgttca aatattgtaa aactttggtg cattgttatt taatagctgt   1920

gatcagtgat tttcaaacct caaatatagt atattaacaa att                     1963


<210>  8
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  9
<211>  5775
<212>  DNA
<213>  Homo sapiens

<400>  9
tcctaggcgg cggccgcggc ggcggaggca gcagcggcgg cggcagtggc ggcggcgaag     60

gtggcggcgg ctcggccagt actcccggcc cccgccattt cggactggga gcgagcgcgg    120

cgcaggcact gaaggcggcg gcggggccag aggctcagcg gctcccaggt gcgggagaga    180

ggcctgctga aaatgactga atataaactt gtggtagttg gagcttgtgg cgtaggcaag    240

agtgccttga cgatacagct aattcagaat cattttgtgg acgaatatga tccaacaata    300

gaggattcct acaggaagca agtagtaatt gatggagaaa cctgtctctt ggatattctc    360

gacacagcag gtcaagagga gtacagtgca atgagggacc agtacatgag gactggggag    420

ggctttcttt gtgtatttgc cataaataat actaaatcat ttgaagatat tcaccattat    480

agagaacaaa ttaaaagagt taaggactct gaagatgtac ctatggtcct agtaggaaat    540

aaatgtgatt tgccttctag aacagtagac acaaaacagg ctcaggactt agcaagaagt    600

tatggaattc cttttattga aacatcagca aagacaagac agggtgttga tgatgccttc    660

tatacattag ttcgagaaat tcgaaaacat aaagaaaaga tgagcaaaga tggtaaaaag    720

aagaaaaaga agtcaaagac aaagtgtgta attatgtaaa tacaatttgt acttttttct    780

taaggcatac tagtacaagt ggtaattttt gtacattaca ctaaattatt agcatttgtt    840

ttagcattac ctaatttttt tcctgctcca tgcagactgt tagcttttac cttaaatgct    900

tattttaaaa tgacagtgga agtttttttt tcctcgaagt gccagtattc ccagagtttt    960

ggtttttgaa ctagcaatgc ctgtgaaaaa gaaactgaat acctaagatt tctgtcttgg   1020

ggtttttggt gcatgcagtt gattacttct tatttttctt accaagtgtg aatgttggtg   1080

tgaaacaaat taatgaagct tttgaatcat ccctattctg tgttttatct agtcacataa   1140

atggattaat tactaatttc agttgagacc ttctaattgg tttttactga aacattgagg   1200

gacacaaatt tatgggcttc ctgatgatga ttcttctagg catcatgtcc tatagtttgt   1260

catccctgat gaatgtaaag ttacactgtt cacaaaggtt ttgtctcctt tccactgcta   1320

ttagtcatgg tcactctccc caaaatatta tattttttct ataaaaagaa aaaaatggaa   1380

aaaaattaca aggcaatgga aactattata aggccatttc cttttcacat tagataaatt   1440

actataaaga ctcctaatag ctttttcctg ttaaggcaga cccagtatga atgggattat   1500

tatagcaacc attttggggc tatatttaca tgctactaaa tttttataat aattgaaaag   1560

attttaacaa gtataaaaaa attctcatag gaattaaatg tagtctccct gtgtcagact   1620

gctctttcat agtataactt taaatctttt cttcaacttg agtctttgaa gatagtttta   1680

attctgcttg tgacattaaa agattatttg ggccagttat agcttattag gtgttgaaga   1740

gaccaaggtt gcaagccagg ccctgtgtga accttgagct ttcatagaga gtttcacagc   1800

atggactgtg tgccccacgg tcatccgagt ggttgtacga tgcattggtt agtcaaaaat   1860

ggggagggac tagggcagtt tggatagctc aacaagatac aatctcactc tgtggtggtc   1920

ctgctgacaa atcaagagca ttgcttttgt ttcttaagaa aacaaactct tttttaaaaa   1980

ttacttttaa atattaactc aaaagttgag attttggggt ggtggtgtgc caagacatta   2040

attttttttt taaacaatga agtgaaaaag ttttacaatc tctaggtttg gctagttctc   2100

ttaacactgg ttaaattaac attgcataaa cacttttcaa gtctgatcca tatttaataa   2160

tgctttaaaa taaaaataaa aacaatcctt ttgataaatt taaaatgtta cttattttaa   2220

aataaatgaa gtgagatggc atggtgaggt gaaagtatca ctggactagg ttgttggtga   2280

cttaggttct agataggtgt cttttaggac tctgattttg aggacatcac ttactatcca   2340

tttcttcatg ttaaaagaag tcatctcaaa ctcttagttt ttttttttta cactatgtga   2400

tttatattcc atttacataa ggatacactt atttgtcaag ctcagcacaa tctgtaaatt   2460

tttaacctat gttacaccat cttcagtgcc agtcttgggc aaaattgtgc aagaggtgaa   2520

gtttatattt gaatatccat tctcgtttta ggactcttct tccatattag tgtcatcttg   2580

cctccctacc ttccacatgc cccatgactt gatgcagttt taatacttgt aattccccta   2640

accataagat ttactgctgc tgtggatatc tccatgaagt tttcccactg agtcacatca   2700

gaaatgccct acatcttatt ttcctcaggg ctcaagagaa tctgacagat accataaagg   2760

gatttgacct aatcactaat tttcaggtgg tggctgatgc tttgaacatc tctttgctgc   2820

ccaatccatt agcgacagta ggatttttca accctggtat gaatagacag aaccctatcc   2880

agtggaagga gaatttaata aagatagtgc agaaagaatt ccttaggtaa tctataacta   2940

ggactactcc tggtaacagt aatacattcc attgttttag taaccagaaa tcttcatgca   3000

atgaaaaata ctttaattca tgaagcttac tttttttttt ttggtgtcag agtctcgctc   3060

ttgtcaccca ggctggaatg cagtggcgcc atctcagctc actgcaacct tccatcttcc   3120

caggttcaag cgattctcgt gcctcggcct cctgagtagc tgggattaca ggcgtgtgca   3180

ctacactcaa ctaatttttg tatttttagg agagacgggg tttcacctgt tggccaggct   3240

ggtctcgaac tcctgacctc aagtgattca cccaccttgg cctcataaac ctgttttgca   3300

gaactcattt attcagcaaa tatttattga gtgcctacca gatgccagtc accgcacaag   3360

gcactgggta tatggtatcc ccaaacaaga gacataatcc cggtccttag gtactgctag   3420

tgtggtctgt aatatcttac taaggccttt ggtatacgac ccagagataa cacgatgcgt   3480

attttagttt tgcaaagaag gggtttggtc tctgtgccag ctctataatt gttttgctac   3540

gattccactg aaactcttcg atcaagctac tttatgtaaa tcacttcatt gttttaaagg   3600

aataaacttg attatattgt ttttttattt ggcataactg tgattctttt aggacaatta   3660

ctgtacacat taaggtgtat gtcagatatt catattgacc caaatgtgta atattccagt   3720

tttctctgca taagtaatta aaatatactt aaaaattaat agttttatct gggtacaaat   3780

aaacagtgcc tgaactagtt cacagacaag ggaaacttct atgtaaaaat cactatgatt   3840

tctgaattgc tatgtgaaac tacagatctt tggaacactg tttaggtagg gtgttaagac   3900

ttgacacagt acctcgtttc tacacagaga aagaaatggc catacttcag gaactgcagt   3960

gcttatgagg ggatatttag gcctcttgaa tttttgatgt agatgggcat ttttttaagg   4020

tagtggttaa ttacctttat gtgaactttg aatggtttaa caaaagattt gtttttgtag   4080

agattttaaa gggggagaat tctagaaata aatgttacct aattattaca gccttaaaga   4140

caaaaatcct tgttgaagtt tttttaaaaa aagactaaat tacatagact taggcattaa   4200

catgtttgtg gaagaatata gcagacgtat attgtatcat ttgagtgaat gttcccaagt   4260

aggcattcta ggctctattt aactgagtca cactgcatag gaatttagaa cctaactttt   4320

ataggttatc aaaactgttg tcaccattgc acaattttgt cctaatatat acatagaaac   4380

tttgtggggc atgttaagtt acagtttgca caagttcatc tcatttgtat tccattgatt   4440

tttttttttc ttctaaacat tttttcttca aaacagtata tataactttt tttaggggat   4500

tttttttaga cagcaaaaaa ctatctgaag atttccattt gtcaaaaagt aatgatttct   4560

tgataattgt gtagtgaatg ttttttagaa cccagcagtt accttgaaag ctgaatttat   4620

atttagtaac ttctgtgtta atactggata gcatgaattc tgcattgaga aactgaatag   4680

ctgtcataaa atgctttctt tcctaaagaa agatactcac atgagttctt gaagaatagt   4740

cataactaga ttaagatctg tgttttagtt taatagtttg aagtgcctgt ttgggataat   4800

gataggtaat ttagatgaat ttaggggaaa aaaaagttat ctgcagttat gttgagggcc   4860

catctctccc cccacacccc cacagagcta actgggttac agtgttttat ccgaaagttt   4920

ccaattccac tgtcttgtgt tttcatgttg aaaatacttt tgcatttttc ctttgagtgc   4980

caatttctta ctagtactat ttcttaatgt aacatgttta cctggcctgt cttttaacta   5040

tttttgtata gtgtaaactg aaacatgcac attttgtaca ttgtgctttc ttttgtgggt   5100

catatgcagt gtgatccagt tgttttccat catttggttg cgctgaccta ggaatgttgg   5160

tcatatcaaa cattaaaaat gaccactctt ttaatgaaat taacttttaa atgtttatag   5220

gagtatgtgc tgtgaagtga tctaaaattt gtaatatttt tgtcatgaac tgtactactc   5280

ctaattattg taatgtaata aaaatagtta cagtgactat gagtgtgtat ttattcatgc   5340

aaatttgaac tgtttgcccc gaaatggata tggatacttt ataagccata gacactatag   5400

tataccagtg aatcttttat gcagcttgtt agaagtatcc ttttattttc taaaaggtgc   5460

tgtggatatt atgtaaaggc gtgtttgctt aaacaatttt ccatatttag aagtagatgc   5520

aaaacaaatc tgcctttatg acaaaaaaat aggataacat tatttattta tttcctttta   5580

tcaataaggt aattgataca caacaggtga cttggtttta ggcccaaagg tagcagcagc   5640

aacattaata atggaaataa ttgaatagtt agttatgtat gttaatgcca gtcaccagca   5700

ggctatttca aggtcagaag taatgactcc atacatatta tttatttcta taactacatt   5760

taaatcatta ccagg                                                    5775


<210>  10
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  11
<211>  571
<212>  DNA
<213>  Homo sapiens

<400>  11
catgacggaa tataagctgg tggtggtggg cgccggcggt gtgggcaaga gtgcgctgac     60

catccagctg atccagaacc attttgtgga cgaatacgac cccactatag aggattccta    120

ccggaagcag gtggtcattg atggggagac gtgcctgttg gacatcctgg ataccgccgg    180

ccaggaggag tacagcgcca tgcgggacca gtacatgcgc accggggagg gcttcctgtg    240

tgtgtttgcc atcaacaaca ccaagtcttt tgaggacatc caccagtaca gggagcagat    300

caaacgggtg aaggactcgg atgacgtgcc catggtgctg gtggggaaca agtgtgacct    360

ggctgcacgc actgtggaat ctcggcaggc tcaggacctc gcccgaagct acggcatccc    420

ctacatcgag acctcggcca agacccggca gggagtggag gatgccttct acacgttggt    480

gcgtgagatc cggcagcaca agctgcggaa gctgaaccct cctgatgaga gtggccccgg    540

ctgcatgagc tgcaagtgtg tgctctcctg a                                   571


<210>  12
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  13
<211>  2477
<212>  DNA
<213>  Homo sapiens

<400>  13
cgcctccctt ccccctcccc gcccgacagc ggccgctcgg gccccggctc tcggttataa     60

gatggcggcg ctgagcggtg gcggtggtgg cggcgcggag ccgggccagg ctctgttcaa    120

cggggacatg gagcccgagg ccggcgccgg cgccggcgcc gcggcctctt cggctgcgga    180

ccctgccatt ccggaggagg tgtggaatat caaacaaatg attaagttga cacaggaaca    240

tatagaggcc ctattggaca aatttggtgg ggagcataat ccaccatcaa tatatctgga    300

ggcctatgaa gaatacacca gcaagctaga tgcactccaa caaagagaac aacagttatt    360

ggaatctctg gggaacggaa ctgatttttc tgtttctagc tctgcatcaa tggataccgt    420

tacatcttct tcctcttcta gcctttcagt gctaccttca tctctttcag tttttcaaaa    480

tcccacagat gtggcacgga gcaaccccaa gtcaccacaa aaacctatcg ttagagtctt    540

cctgcccaac aaacagagga cagtggtacc tgcaaggtgt ggagttacag tccgagacag    600

tctaaagaaa gcactgatga tgagaggtct aatcccagag tgctgtgctg tttacagaat    660

tcaggatgga gagaagaaac caattggttg ggacactgat atttcctggc ttactggaga    720

agaattgcat gtggaagtgt tggagaatgt tccacttaca acacacaact ttgtacgaaa    780

aacgtttttc accttagcat tttgtgactt ttgtcgaaag ctgcttttcc agggtttccg    840

ctgtcaaaca tgtggttata aatttcacca gcgttgtagt acagaagttc cactgatgtg    900

tgttaattat gaccaacttg atttgctgtt tgtctccaag ttctttgaac accacccaat    960

accacaggaa gaggcgtcct tagcagagac tgccctaaca tctggatcat ccccttccgc   1020

acccgcctcg gactctattg ggccccaaat tctcaccagt ccgtctcctt caaaatccat   1080

tccaattcca cagcccttcc gaccagcaga tgaagatcat cgaaatcaat ttgggcaacg   1140

agaccgatcc tcatcagctc ccaatgtgca tataaacaca atagaacctg tcaatattga   1200

tgacttgatt agagaccaag gatttcgtgg tgatggagga tcaaccacag gtttgtctgc   1260

taccccccct gcctcattac ctggctcact aactaacgtg aaagccttac agaaatctcc   1320

aggacctcag cgagaaagga agtcatcttc atcctcagaa gacaggaatc gaatgaaaac   1380

acttggtaga cgggactcga gtgatgattg ggagattcct gatgggcaga ttacagtggg   1440

acaaagaatt ggatctggat catttggaac agtctacaag ggaaagtggc atggtgatgt   1500

ggcagtgaaa atgttgaatg tgacagcacc tacacctcag cagttacaag ccttcaaaaa   1560

tgaagtagga gtactcagga aaacacgaca tgtgaatatc ctactcttca tgggctattc   1620

cacaaagcca caactggcta ttgttaccca gtggtgtgag ggctccagct tgtatcacca   1680

tctccatatc attgagacca aatttgagat gatcaaactt atagatattg cacgacagac   1740

tgcacagggc atggattact tacacgccaa gtcaatcatc cacagagacc tcaagagtaa   1800

taatatattt cttcatgaag acctcacagt aaaaataggt gattttggtc tagctacagt   1860

gaaatctcga tggagtgggt cccatcagtt tgaacagttg tctggatcca ttttgtggat   1920

ggcaccagaa gtcatcagaa tgcaagataa aaatccatac agctttcagt cagatgtata   1980

tgcatttgga attgttctgt atgaattgat gactggacag ttaccttatt caaacatcaa   2040

caacagggac cagataattt ttatggtggg acgaggatac ctgtctccag atctcagtaa   2100

ggtacggagt aactgtccaa aagccatgaa gagattaatg gcagagtgcc tcaaaaagaa   2160

aagagatgag agaccactct ttccccaaat tctcgcctct attgagctgc tggcccgctc   2220

attgccaaaa attcaccgca gtgcatcaga accctccttg aatcgggctg gtttccaaac   2280

agaggatttt agtctatatg cttgtgcttc tccaaaaaca cccatccagg cagggggata   2340

tggtgcgttt cctgtccact gaaacaaatg agtgagagag ttcaggagag tagcaacaaa   2400

aggaaaataa atgaacatat gtttgcttat atgttaaatt gaataaaata ctctcttttt   2460

ttttaaggtg aaccaaa                                                  2477


<210>  14
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210>  15
<211>  5916
<212>  DNA
<213>  Homo sapiens

<400>  15
gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg     60

gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt    120

cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga    180

gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac    240

atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac    300

gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc    360

tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag    420

caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat    480

gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat    540

gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac    600

ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc    660

cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc    720

tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac    780

acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg    840

aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa    900

atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt    960

ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct   1020

aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca   1080

aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag   1140

aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt   1200

gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag   1260

gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct   1320

taaatttgtc aggacaaggg ctcagaggac tggacgtgct cagacatcgg tgttcttctt   1380

cccagttctt gacccctggt cctgtctcca gcccgtcttg gcttatccac tttgactcct   1440

ttgagccgtt tggaggggcg gtttctggta gttgtggctt ttatgctttc aaagaatttc   1500

ttcagtccag agaattcctc ctggcagccc tgtgtgtgtc acccattggt gacctgcggc   1560

agtatgtact tcagtgcacc tactgcttac tgttgcttta gtcactaatt gctttctggt   1620

ttgaaagatg cagtggttcc tccctctcct gaatcctttt ctacatgatg ccctgctgac   1680

catgcagccg caccagagag agattcttcc ccaattggct ctagtcactg gcatctcact   1740

ttatgatagg gaaggctact acctagggca ctttaagtca gtgacagccc cttatttgca   1800

cttcaccttt tgaccataac tgtttcccca gagcaggagc ttgtggaaat accttggctg   1860

atgttgcagc ctgcagcaag tgcttccgtc tccggaatcc ttggggagca cttgtccacg   1920

tcttttctca tatcatggta gtcactaaca tatataaggt atgtgctatt ggcccagctt   1980

ttagaaaatg cagtcatttt tctaaataaa aaggaagtac tgcacccagc agtgtcactc   2040

tgtagttact gtggtcactt gtaccatata gaggtgtaac acttgtcaag aagcgttatg   2100

tgcagtactt aatgtttgta agacttacaa aaaaagattt aaagtggcag cttcactcga   2160

catttggtga gagaagtaca aaggttgcag tgctgagctg tgggcggttt ctggggatgt   2220

cccagggtgg aactccacat gctggtgcat atacgccctt gagctacttc aaatgtgggt   2280

gtttcagtaa ccacgttcca tgcctgagga tttagcagag aggaacactg cgtctttaaa   2340

tgagaaagta tacaattctt tttccttcta cagcatgtca gcatctcaag ttcatttttc   2400

aacctacagt ataacaattt gtaataaagc ctccaggagc tcatgacgtg aagcactgtt   2460

ctgtcctcaa gtactcaaat atttctgata ctgctgagtc agactgtcag aaaaagctag   2520

cactaactcg tgtttggagc tctatccata ttttactgat ctctttaagt atttgttcct   2580

gccactgtgt actgtggagt tgactcggtg ttctgtccca gtgcggtgcc tcctcttgac   2640

ttccccactg ctctctgtgg tgagaaattt gccttgttca ataattactg taccctcgca   2700

tgactgttac agctttctgt gcagagatga ctgtccaagt gccacatgcc tacgattgaa   2760

atgaaaactc tattgttacc tctgagttgt gttccacgga aaatgctatc cagcagatca   2820

tttaggaaaa ataattctat ttttagcttt tcatttctca gctgtccttt tttcttgttt   2880

gatttttgac agcaatggag aatgggttat ataaagactg cctgctaata tgaacagaaa   2940

tgcatttgta attcatgaaa ataaatgtac atcttctatc ttcacattca tgttaagatt   3000

cagtgttgct ttcctctgga tcagcgtgtc tgaatggaca gtcaggttca ggttgtgctg   3060

aacacagaaa tgctcacagg cctcactttg ccgcccaggc actggcccag cacttggatt   3120

tacataagat gagttagaaa ggtacttctg tagggtcctt tttacctctg ctcggcagag   3180

aatcgatgct gtcatgttcc tttattcaca atcttaggtc tcaaatattc tgtcaaaccc   3240

taacaaagaa gccccgacat ctcaggttgg attccctggt tctctctaaa gagggcctgc   3300

ccttgtgccc cagaggtgct gctgggcaca gccaagagtt gggaagggcc gccccacagt   3360

acgcagtcct caccacccag cccagggtgc tcacgctcac cactcctgtg gctgaggaag   3420

gatagctggc tcatcctcgg aaaacagacc cacatctcta ttcttgccct gaaatacgcg   3480

cttttcactt gcgtgctcag agctgccgtc tgaaggtcca cacagcattg acgggacaca   3540

gaaatgtgac tgttaccgga taacactgat tagtcagttt tcatttataa aaaagcattg   3600

acagttttat tactcttgtt tctttttaaa tggaaagtta ctattataag gttaatttgg   3660

agtcctcttc taaatagaaa accatatcct tggctactaa catctggaga ctgtgagctc   3720

cttcccattc cccttcctgg tactgtggag tcagattggc atgaaaccac taacttcatt   3780

ctagaatcat tgtagccata agttgtgtgc tttttattaa tcatgccaaa cataatgtaa   3840

ctgggcagag aatggtccta accaaggtac ctatgaaaag cgctagctat catgtgtagt   3900

agatgcatca ttttggctct tcttacattt gtaaaaatgt acagattagg tcatcttaat   3960

tcatattagt gacacggaac agcacctcca ctatttgtat gttcaaataa gctttcagac   4020

taatagcttt tttggtgtct aaaatgtaag caaaaaattc ctgctgaaac attccagtcc   4080

tttcatttag tataaaagaa atactgaaca agccagtggg atggaattga aagaactaat   4140

catgaggact ctgtcctgac acaggtcctc aaagctagca gagatacgca gacattgtgg   4200

catctgggta gaagaatact gtattgtgtg tgcagtgcac agtgtgtggt gtgtgcacac   4260

tcattccttc tgctcttggg cacaggcagt gggtgtagag gtaaccagta gctttgagaa   4320

gctacatgta gctcaccagt ggttttctct aaggaatcac aaaagtaaac tacccaacca   4380

catgccacgt aatatttcag ccattcagag gaaactgttt tctctttatt tgcttatatg   4440

ttaatatggt ttttaaattg gtaactttta tatagtatgg taacagtatg ttaatacaca   4500

catacatacg cacacatgct ttgggtcctt ccataatact tttatatttg taaatcaatg   4560

ttttggagca atcccaagtt taagggaaat atttttgtaa atgtaatggt tttgaaaatc   4620

tgagcaatcc ttttgcttat acatttttaa agcatttgtg ctttaaaatt gttatgctgg   4680

tgtttgaaac atgatactcc tgtggtgcag atgagaagct ataacagtga atatgtggtt   4740

tctcttacgt catccacctt gacatgatgg gtcagaaaca aatggaaatc cagagcaagt   4800

cctccagggt tgcaccaggt ttacctaaag cttgttgcct tttcttgtgc tgtttatgcg   4860

tgtagagcac tcaagaaagt tctgaaactg ctttgtatct gctttgtact gttggtgcct   4920

tcttggtatt gtaccccaaa attctgcata gattatttag tataatggta agttaaaaaa   4980

tgttaaagga agattttatt aagaatctga atgtttattc attatattgt tacaatttaa   5040

cattaacatt tatttgtggt atttgtgatt tggttaatct gtataaaaat tgtaagtaga   5100

aaggtttata tttcatctta attcttttga tgttgtaaac gtacttttta aaagatggat   5160

tatttgaatg tttatggcac ctgacttgta aaaaaaaaaa actacaaaaa aatccttaga   5220

atcattaaat tgtgtccctg tattaccaaa ataacacagc accgtgcatg tatagtttaa   5280

ttgcagtttc atctgtgaaa acgtgaaatt gtctagtcct tcgttatgtt ccccagatgt   5340

cttccagatt tgctctgcat gtggtaactt gtgttagggc tgtgagctgt tcctcgagtt   5400

gaatggggat gtcagtgctc ctagggttct ccaggtggtt cttcagacct tcacctgtgg   5460

gggggggggt aggcggtgcc cacgcccatc tcctcatcct cctgaacttc tgcaacccca   5520

ctgctgggca gacatcctgg gcaacccctt ttttcagagc aagaagtcat aaagatagga   5580

tttcttggac atttggttct tatcaatatt gggcattatg taatgactta tttacaaaac   5640

aaagatactg gaaaatgttt tggatgtggt gttatggaaa gagcacaggc cttggaccca   5700

tccagctggg ttcagaacta ccccctgctt ataactgcgg ctggctgtgg gccagtcatt   5760

ctgcgtctct gctttcttcc tctgcttcag actgtcagct gtaaagtgga agcaatatta   5820

cttgccttgt atatggtaaa gattataaaa atacatttca actgttcagc atagtacttc   5880

aaagcaagta ctcagtaaat agcaagtctt tttaaa                             5916


<210>  16
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  17
<211>  1499
<212>  DNA
<213>  Homo sapiens

<400>  17
gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg     60

gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt    120

cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga    180

gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac    240

atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac    300

gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc    360

tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag    420

caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat    480

gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat    540

gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac    600

ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc    660

cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc    720

tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac    780

acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg    840

aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa    900

atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt    960

ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct   1020

aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca   1080

aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag   1140

aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt   1200

gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag   1260

gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct   1320

taaatttgtc aggtacctgg agtttaatac agtgagctct agcaagggag gcgctgcctt   1380

ttgtttctag aatattatgt tcctcaaggt ccattatttt gtattctttt ccaagctcct   1440

tattggaagg tattttttta aatttagaat taaaaattat ttagaaagtt acatataaa    1499


<210>  18
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<220>
<223>  Primer A

<400>  19
gagtggttac gcgcggcgcg                                                   20


<210>  20
<211>  22
<212>  DNA
<213>  Homo sapiens

<220>
<223>  MEK Primer

<400>  20
gcagagctgg tcccgttaac tg                                                22


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<220>
<223>  Primer B

<400>  21
gcactactcg cctctgcacg                                                   20


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<220>
<223>  Luc2 Primer

<400>  22
cgctgaattg gaatccatct tg                                                22


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<220>
<223>  Primer TK1

<400>  23
ccgcgtttat gaacaaacg                                                    19


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<220>
<223>  Primer TK2

<400>  24
gcagatcttg gtggcgtg                                                     18


