                         SEQUENCE LISTING

<110>  GENZYME CORPORATION
       BAGLEY, Rebecca
       KAPLAN, Johanne
       TEICHER, Beverly
       STEFANO, Jim
       PAN, Clark
 
<120>  SOLUBLE FLT CONSTRUCTS FOR TREATING CANCERS

<130>  0800-0058.40

<150>  US 61/089,311
<151>  2008-08-15

<150>  US 61/092,505
<151>  2008-08-28

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence encoding recombinant fusion protein

<400>  1
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatctg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      120

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      180

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      240

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      300

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccggtgga      360

ggtggaggtg gaggtggagg tcctaaatct tgtgacaaaa ctcacacatg cccaccgtgc      420

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      480

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      540

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      600

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      660

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      720

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      780

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc      840

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      900

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag      960

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1020

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatag        1077


<210>  2
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant fusion protein

<400>  2

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Gly Arg Pro Phe Val Glu Met Tyr Ser 
            20                  25                  30          


Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile 
        35                  40                  45              


Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe 
    50                  55                  60                  


Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser 
65                  70                  75                  80  


Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr 
            100                 105                 110         


Leu Thr His Arg Gln Thr Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro 
        115                 120                 125             


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            260                 265                 270         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         


Ser Leu Ser Pro Gly Lys 
        355             


<210>  3
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence encoding recombinant fusion protein

<400>  3
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatctg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      120

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      180

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      240

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      300

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aacccctaaa      360

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      420

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      480

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      540

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      600

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      660

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      720

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg      780

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      840

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      900

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      960

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1020

aagagcctct ccctgtctcc gggtaaatag                                      1050


<210>  4
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant fusion protein

<400>  4

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Gly Arg Pro Phe Val Glu Met Tyr Ser 
            20                  25                  30          


Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile 
        35                  40                  45              


Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe 
    50                  55                  60                  


Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser 
65                  70                  75                  80  


Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr 
            100                 105                 110         


Leu Thr His Arg Gln Thr Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
        115                 120                 125             


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
    130                 135                 140                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
145                 150                 155                 160 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                165                 170                 175     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            180                 185                 190         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        195                 200                 205             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    210                 215                 220                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
225                 230                 235                 240 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                245                 250                 255     


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            260                 265                 270         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        275                 280                 285             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    290                 295                 300                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
305                 310                 315                 320 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                325                 330                 335     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 


<210>  5
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence encoding recombinant fusion protein

<400>  5
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatctg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      120

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      180

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      240

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      300

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccggtgga      360

ggtggaggtg gaggtggagg tccttcctgt gtgcccctga tgcgatgcgg gggctgctgc      420

aattag                                                                 426


<210>  6
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant fusion protein

<400>  6

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Gly Arg Pro Phe Val Glu Met Tyr Ser 
            20                  25                  30          


Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile 
        35                  40                  45              


Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe 
    50                  55                  60                  


Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser 
65                  70                  75                  80  


Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr 
            100                 105                 110         


Leu Thr His Arg Gln Thr Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro 
        115                 120                 125             


Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
    130                 135                 140     


<210>  7
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence encoding recombinant fusion protein

<400>  7
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatctg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      120

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      180

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      240

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      300

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccggtgga      360

ggtggaggtg gaggtggagg tccttcctgt gtgcccctga tgcgatgcgg gggctgctgc      420

aatcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      480

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      540

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      600

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      660

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      720

ctctccctgt ctccgggtaa atag                                             744


<210>  8
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant fusion protein

<400>  8

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Gly Arg Pro Phe Val Glu Met Tyr Ser 
            20                  25                  30          


Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile 
        35                  40                  45              


Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe 
    50                  55                  60                  


Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser 
65                  70                  75                  80  


Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr 
            100                 105                 110         


Leu Thr His Arg Gln Thr Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro 
        115                 120                 125             


Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210>  9
<211>  1434
<212>  DNA
<213>  Homo sapiens

<400>  9
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcgt ctggattcac cttcagtaat tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagctata tggtatgatg gaagtaataa atactatgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gttgtatatg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt attgtgcgag agagggtcgg      360

tgggtacgat atactacggt gactactatc ggatactact ttgactactg gggccaggga      420

accctggtca ccgtctcctc agcctccacc aagggcccat cggtcttccc cctggcaccc      480

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      540

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      600

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      660

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      720

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      780

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggtaa atga           1434


<210>  10
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Met Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Arg Trp Val Arg Tyr Thr Thr Val Thr 
        115                 120                 125             


Thr Ile Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  11
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  11
atgaactttc tgctgtcttg ggtgcattgg agccttgcct tgctgctcta cctccaccat       60

gccaagtggt cccaggctgc acccatggca gaaggaggag ggcagaatca tcacgaagtg      120

gtgaagttca tggatgtcta tcagcgcagc tactgccatc caatcgagac cctggtggac      180

atcttccagg agtaccctga tgagatcgag tacatcttca agccatcctg tgtgcccctg      240

atgcgatgcg ggggctgctg caatgacgag ggcctggagt gtgtgcccac tgaggagtcc      300

aacatcacca tgcagattat gcggatcaaa cctcaccaag gccagcacat aggagagatg      360

agcttcctac agcacaacaa atgtgaatgc agaccaaaga aagatagagc aagacaagaa      420

aaaaaatcag ttcgaggaaa gggaaagggg caaaaacgaa agcgcaagaa atcccggtat      480

aagtcctgga gcgttccctg tgggccttgc tcagagcgga gaaagcattt gtttgtacaa      540

gatccgcaga cgtgtaaatg ttcctgcaaa aacacagact cgcgttgcaa ggcgaggcag      600

cttgagttaa acgaacgtac ttgcagatgt gacaagccga ggcggtga                   648


<210>  12
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His 
                165                 170                 175     


Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr 
            180                 185                 190         


Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys 
        195                 200                 205             


Arg Cys Asp Lys Pro Arg Arg 
    210                 215 


<210>  13
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  13

Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
1               5                   10                  


<210>  14
<211>  5777
<212>  DNA
<213>  Homo sapiens

<400>  14
gcggacactc ctctcggctc ctccccggca gcggcggcgg ctcggagcgg gctccggggc       60

tcgggtgcag cggccagcgg gcctggcggc gaggattacc cggggaagtg gttgtctcct      120

ggctggagcc gcgagacggg cgctcagggc gcggggccgg cggcggcgaa cgagaggacg      180

gactctggcg gccgggtcgt tggccggggg agcgcgggca ccgggcgagc aggccgcgtc      240

gcgctcacca tggtcagcta ctgggacacc ggggtcctgc tgtgcgcgct gctcagctgt      300

ctgcttctca caggatctag ttcaggttca aaattaaaag atcctgaact gagtttaaaa      360

ggcacccagc acatcatgca agcaggccag acactgcatc tccaatgcag gggggaagca      420

gcccataaat ggtctttgcc tgaaatggtg agtaaggaaa gcgaaaggct gagcataact      480

aaatctgcct gtggaagaaa tggcaaacaa ttctgcagta ctttaacctt gaacacagct      540

caagcaaacc acactggctt ctacagctgc aaatatctag ctgtacctac ttcaaagaag      600

aaggaaacag aatctgcaat ctatatattt attagtgata caggtagacc tttcgtagag      660

atgtacagtg aaatccccga aattatacac atgactgaag gaagggagct cgtcattccc      720

tgccgggtta cgtcacctaa catcactgtt actttaaaaa agtttccact tgacactttg      780

atccctgatg gaaaacgcat aatctgggac agtagaaagg gcttcatcat atcaaatgca      840

acgtacaaag aaatagggct tctgacctgt gaagcaacag tcaatgggca tttgtataag      900

acaaactatc tcacacatcg acaaaccaat acaatcatag atgtccaaat aagcacacca      960

cgcccagtca aattacttag aggccatact cttgtcctca attgtactgc taccactccc     1020

ttgaacacga gagttcaaat gacctggagt taccctgatg aaaaaaataa gagagcttcc     1080

gtaaggcgac gaattgacca aagcaattcc catgccaaca tattctacag tgttcttact     1140

attgacaaaa tgcagaacaa agacaaagga ctttatactt gtcgtgtaag gagtggacca     1200

tcattcaaat ctgttaacac ctcagtgcat atatatgata aagcattcat cactgtgaaa     1260

catcgaaaac agcaggtgct tgaaaccgta gctggcaagc ggtcttaccg gctctctatg     1320

aaagtgaagg catttccctc gccggaagtt gtatggttaa aagatgggtt acctgcgact     1380

gagaaatctg ctcgctattt gactcgtggc tactcgttaa ttatcaagga cgtaactgaa     1440

gaggatgcag ggaattatac aatcttgctg agcataaaac agtcaaatgt gtttaaaaac     1500

ctcactgcca ctctaattgt caatgtgaaa ccccagattt acgaaaaggc cgtgtcatcg     1560

tttccagacc cggctctcta cccactgggc agcagacaaa tcctgacttg taccgcatat     1620

ggtatccctc aacctacaat caagtggttc tggcacccct gtaaccataa tcattccgaa     1680

gcaaggtgtg acttttgttc caataatgaa gagtccttta tcctggatgc tgacagcaac     1740

atgggaaaca gaattgagag catcactcag cgcatggcaa taatagaagg aaagaataag     1800

atggctagca ccttggttgt ggctgactct agaatttctg gaatctacat ttgcatagct     1860

tccaataaag ttgggactgt gggaagaaac ataagctttt atatcacaga tgtgccaaat     1920

gggtttcatg ttaacttgga aaaaatgccg acggaaggag aggacctgaa actgtcttgc     1980

acagttaaca agttcttata cagagacgtt acttggattt tactgcggac agttaataac     2040

agaacaatgc actacagtat tagcaagcaa aaaatggcca tcactaagga gcactccatc     2100

actcttaatc ttaccatcat gaatgtttcc ctgcaagatt caggcaccta tgcctgcaga     2160

gccaggaatg tatacacagg ggaagaaatc ctccagaaga aagaaattac aatcagagat     2220

caggaagcac catacctcct gcgaaacctc agtgatcaca cagtggccat cagcagttcc     2280

accactttag actgtcatgc taatggtgtc cccgagcctc agatcacttg gtttaaaaac     2340

aaccacaaaa tacaacaaga gcctggaatt attttaggac caggaagcag cacgctgttt     2400

attgaaagag tcacagaaga ggatgaaggt gtctatcact gcaaagccac caaccagaag     2460

ggctctgtgg aaagttcagc atacctcact gttcaaggaa cctcggacaa gtctaatctg     2520

gagctgatca ctctaacatg cacctgtgtg gctgcgactc tcttctggct cctattaacc     2580

ctccttatcc gaaaaatgaa aaggtcttct tctgaaataa agactgacta cctatcaatt     2640

ataatggacc cagatgaagt tcctttggat gagcagtgtg agcggctccc ttatgatgcc     2700

agcaagtggg agtttgcccg ggagagactt aaactgggca aatcacttgg aagaggggct     2760

tttggaaaag tggttcaagc atcagcattt ggcattaaga aatcacctac gtgccggact     2820

gtggctgtga aaatgctgaa agagggggcc acggccagcg agtacaaagc tctgatgact     2880

gagctaaaaa tcttgaccca cattggccac catctgaacg tggttaacct gctgggagcc     2940

tgcaccaagc aaggagggcc tctgatggtg attgttgaat actgcaaata tggaaatctc     3000

tccaactacc tcaagagcaa acgtgactta ttttttctca acaaggatgc agcactacac     3060

atggagccta agaaagaaaa aatggagcca ggcctggaac aaggcaagaa accaagacta     3120

gatagcgtca ccagcagcga aagctttgcg agctccggct ttcaggaaga taaaagtctg     3180

agtgatgttg aggaagagga ggattctgac ggtttctaca aggagcccat cactatggaa     3240

gatctgattt cttacagttt tcaagtggcc agaggcatgg agttcctgtc ttccagaaag     3300

tgcattcatc gggacctggc agcgagaaac attcttttat ctgagaacaa cgtggtgaag     3360

atttgtgatt ttggccttgc ccgggatatt tataagaacc ccgattatgt gagaaaagga     3420

gatactcgac ttcctctgaa atggatggct cccgaatcta tctttgacaa aatctacagc     3480

accaagagcg acgtgtggtc ttacggagta ttgctgtggg aaatcttctc cttaggtggg     3540

tctccatacc caggagtaca aatggatgag gacttttgca gtcgcctgag ggaaggcatg     3600

aggatgagag ctcctgagta ctctactcct gaaatctatc agatcatgct ggactgctgg     3660

cacagagacc caaaagaaag gccaagattt gcagaacttg tggaaaaact aggtgatttg     3720

cttcaagcaa atgtacaaca ggatggtaaa gactacatcc caatcaatgc catactgaca     3780

ggaaatagtg ggtttacata ctcaactcct gccttctctg aggacttctt caaggaaagt     3840

atttcagctc cgaagtttaa ttcaggaagc tctgatgatg tcagatatgt aaatgctttc     3900

aagttcatga gcctggaaag aatcaaaacc tttgaagaac ttttaccgaa tgccacctcc     3960

atgtttgatg actaccaggg cgacagcagc actctgttgg cctctcccat gctgaagcgc     4020

ttcacctgga ctgacagcaa acccaaggcc tcgctcaaga ttgacttgag agtaaccagt     4080

aaaagtaagg agtcggggct gtctgatgtc agcaggccca gtttctgcca ttccagctgt     4140

gggcacgtca gcgaaggcaa gcgcaggttc acctacgacc acgctgagct ggaaaggaaa     4200

atcgcgtgct gctccccgcc cccagactac aactcggtgg tcctgtactc caccccaccc     4260

atctagagtt tgacacgaag ccttatttct agaagcacat gtgtatttat acccccagga     4320

aactagcttt tgccagtatt atgcatatat aagtttacac ctttatcttt ccatgggagc     4380

cagctgcttt ttgtgatttt tttaatagtg cttttttttt ttgactaaca agaatgtaac     4440

tccagataga gaaatagtga caagtgaaga acactactgc taaatcctca tgttactcag     4500

tgttagagaa atccttccta aacccaatga cttccctgct ccaacccccg ccacctcagg     4560

gcacgcagga ccagtttgat tgaggagctg cactgatcac ccaatgcatc acgtacccca     4620

ctgggccagc cctgcagccc aaaacccagg gcaacaagcc cgttagcccc aggggatcac     4680

tggctggcct gagcaacatc tcgggagtcc tctagcaggc ctaagacatg tgaggaggaa     4740

aaggaaaaaa agcaaaaagc aagggagaaa agagaaaccg ggagaaggca tgagaaagaa     4800

tttgagacgc accatgtggg cacggagggg gacggggctc agcaatgcca tttcagtggc     4860

ttcccagctc tgacccttct acatttgagg gcccagccag gagcagatgg acagcgatga     4920

ggggacattt tctggattct gggaggcaag aaaaggacaa atatcttttt tggaactaaa     4980

gcaaatttta gacctttacc tatggaagtg gttctatgtc cattctcatt cgtggcatgt     5040

tttgatttgt agcactgagg gtggcactca actctgagcc catacttttg gctcctctag     5100

taagatgcac tgaaaactta gccagagtta ggttgtctcc aggccatgat ggccttacac     5160

tgaaaatgtc acattctatt ttgggtatta atatatagtc cagacactta actcaatttc     5220

ttggtattat tctgttttgc acagttagtt gtgaaagaaa gctgagaaga atgaaaatgc     5280

agtcctgagg agagttttct ccatatcaaa acgagggctg atggaggaaa aaggtcaata     5340

aggtcaaggg aagaccccgt ctctatacca accaaaccaa ttcaccaaca cagttgggac     5400

ccaaaacaca ggaagtcagt cacgtttcct tttcatttaa tggggattcc actatctcac     5460

actaatctga aaggatgtgg aagagcatta gctggcgcat attaagcact ttaagctcct     5520

tgagtaaaaa ggtggtatgt aatttatgca aggtatttct ccagttggga ctcaggatat     5580

tagttaatga gccatcacta gaagaaaagc ccattttcaa ctgctttgaa acttgcctgg     5640

ggtctgagca tgatgggaat agggagacag ggtaggaaag ggcgcctact cttcagggtc     5700

taaagatcaa gtgggccttg gatcgctaag ctggctctgt ttgatgctat ttatgcaagt     5760

tagggtctat gtattta                                                    5777


<210>  15
<211>  1338
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Flt-1 (VEGF-R1) Receptor Protein

<400>  15

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Leu Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210>  16
<211>  5830
<212>  DNA
<213>  Homo sapiens

<400>  16
actgagtccc gggaccccgg gagagcggtc agtgtgtggt cgctgcgttt cctctgcctg       60

cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta      120

ccggcacccg cagacgcccc tgcagccgcc ggtcggcgcc cgggctccct agccctgtgc      180

gctcaactgt cctgcgctgc ggggtgccgc gagttccacc tccgcgcctc cttctctaga      240

caggcgctgg gagaaagaac cggctcccga gttctgggca tttcgcccgg ctcgaggtgc      300

aggatgcaga gcaaggtgct gctggccgtc gccctgtggc tctgcgtgga gacccgggcc      360

gcctctgtgg gtttgcctag tgtttctctt gatctgccca ggctcagcat acaaaaagac      420

atacttacaa ttaaggctaa tacaactctt caaattactt gcaggggaca gagggacttg      480

gactggcttt ggcccaataa tcagagtggc agtgagcaaa gggtggaggt gactgagtgc      540

agcgatggcc tcttctgtaa gacactcaca attccaaaag tgatcggaaa tgacactgga      600

gcctacaagt gcttctaccg ggaaactgac ttggcctcgg tcatttatgt ctatgttcaa      660

gattacagat ctccatttat tgcttctgtt agtgaccaac atggagtcgt gtacattact      720

gagaacaaaa acaaaactgt ggtgattcca tgtctcgggt ccatttcaaa tctcaacgtg      780

tcactttgtg caagataccc agaaaagaga tttgttcctg atggtaacag aatttcctgg      840

gacagcaaga agggctttac tattcccagc tacatgatca gctatgctgg catggtcttc      900

tgtgaagcaa aaattaatga tgaaagttac cagtctatta tgtacatagt tgtcgttgta      960

gggtatagga tttatgatgt ggttctgagt ccgtctcatg gaattgaact atctgttgga     1020

gaaaagcttg tcttaaattg tacagcaaga actgaactaa atgtggggat tgacttcaac     1080

tgggaatacc cttcttcgaa gcatcagcat aagaaacttg taaaccgaga cctaaaaacc     1140

cagtctggga gtgagatgaa gaaatttttg agcaccttaa ctatagatgg tgtaacccgg     1200

agtgaccaag gattgtacac ctgtgcagca tccagtgggc tgatgaccaa gaagaacagc     1260

acatttgtca gggtccatga aaaacctttt gttgcttttg gaagtggcat ggaatctctg     1320

gtggaagcca cggtggggga gcgtgtcaga atccctgcga agtaccttgg ttacccaccc     1380

ccagaaataa aatggtataa aaatggaata ccccttgagt ccaatcacac aattaaagcg     1440

gggcatgtac tgacgattat ggaagtgagt gaaagagaca caggaaatta cactgtcatc     1500

cttaccaatc ccatttcaaa ggagaagcag agccatgtgg tctctctggt tgtgtatgtc     1560

ccaccccaga ttggtgagaa atctctaatc tctcctgtgg attcctacca gtacggcacc     1620

actcaaacgc tgacatgtac ggtctatgcc attcctcccc cgcatcacat ccactggtat     1680

tggcagttgg aggaagagtg cgccaacgag cccagccaag ctgtctcagt gacaaaccca     1740

tacccttgtg aagaatggag aagtgtggag gacttccagg gaggaaataa aattgaagtt     1800

aataaaaatc aatttgctct aattgaagga aaaaacaaaa ctgtaagtac ccttgttatc     1860

caagcggcaa atgtgtcagc tttgtacaaa tgtgaagcgg tcaacaaagt cgggagagga     1920

gagagggtga tctccttcca cgtgaccagg ggtcctgaaa ttactttgca acctgacatg     1980

cagcccactg agcaggagag cgtgtctttg tggtgcactg cagacagatc tacgtttgag     2040

aacctcacat ggtacaagct tggcccacag cctctgccaa tccatgtggg agagttgccc     2100

acacctgttt gcaagaactt ggatactctt tggaaattga atgccaccat gttctctaat     2160

agcacaaatg acattttgat catggagctt aagaatgcat ccttgcagga ccaaggagac     2220

tatgtctgcc ttgctcaaga caggaagacc aagaaaagac attgcgtggt caggcagctc     2280

acagtcctag agcgtgtggc acccacgatc acaggaaacc tggagaatca gacgacaagt     2340

attggggaaa gcatcgaagt ctcatgcacg gcatctggga atccccctcc acagatcatg     2400

tggtttaaag ataatgagac ccttgtagaa gactcaggca ttgtattgaa ggatgggaac     2460

cggaacctca ctatccgcag agtgaggaag gaggacgaag gcctctacac ctgccaggca     2520

tgcagtgttc ttggctgtgc aaaagtggag gcatttttca taatagaagg tgcccaggaa     2580

aagacgaact tggaaatcat tattctagta ggcacggcgg tgattgccat gttcttctgg     2640

ctacttcttg tcatcatcct acggaccgtt aagcgggcca atggagggga actgaagaca     2700

ggctacttgt ccatcgtcat ggatccagat gaactcccat tggatgaaca ttgtgaacga     2760

ctgccttatg atgccagcaa atgggaattc cccagagacc ggctgaagct aggtaagcct     2820

cttggccgtg gtgcctttgg ccaagtgatt gaagcagatg cctttggaat tgacaagaca     2880

gcaacttgca ggacagtagc agtcaaaatg ttgaaagaag gagcaacaca cagtgagcat     2940

cgagctctca tgtctgaact caagatcctc attcatattg gtcaccatct caatgtggtc     3000

aaccttctag gtgcctgtac caagccagga gggccactca tggtgattgt ggaattctgc     3060

aaatttggaa acctgtccac ttacctgagg agcaagagaa atgaatttgt cccctacaag     3120

accaaagggg cacgattccg tcaagggaaa gactacgttg gagcaatccc tgtggatctg     3180

aaacggcgct tggacagcat caccagtagc cagagctcag ccagctctgg atttgtggag     3240

gagaagtccc tcagtgatgt agaagaagag gaagctcctg aagatctgta taaggacttc     3300

ctgaccttgg agcatctcat ctgttacagc ttccaagtgg ctaagggcat ggagttcttg     3360

gcatcgcgaa agtgtatcca cagggacctg gcggcacgaa atatcctctt atcggagaag     3420

aacgtggtta aaatctgtga ctttggcttg gcccgggata tttataaaga tccagattat     3480

gtcagaaaag gagatgctcg cctccctttg aaatggatgg ccccagaaac aatttttgac     3540

agagtgtaca caatccagag tgacgtctgg tcttttggtg ttttgctgtg ggaaatattt     3600

tccttaggtg cttctccata tcctggggta aagattgatg aagaattttg taggcgattg     3660

aaagaaggaa ctagaatgag ggcccctgat tatactacac cagaaatgta ccagaccatg     3720

ctggactgct ggcacgggga gcccagtcag agacccacgt tttcagagtt ggtggaacat     3780

ttgggaaatc tcttgcaagc taatgctcag caggatggca aagactacat tgttcttccg     3840

atatcagaga ctttgagcat ggaagaggat tctggactct ctctgcctac ctcacctgtt     3900

tcctgtatgg aggaggagga agtatgtgac cccaaattcc attatgacaa cacagcagga     3960

atcagtcagt atctgcagaa cagtaagcga aagagccggc ctgtgagtgt aaaaacattt     4020

gaagatatcc cgttagaaga accagaagta aaagtaatcc cagatgacaa ccagacggac     4080

agtggtatgg ttcttgcctc agaagagctg aaaactttgg aagacagaac caaattatct     4140

ccatcttttg gtggaatggt gcccagcaaa agcagggagt ctgtggcatc tgaaggctca     4200

aaccagacaa gcggctacca gtccggatat cactccgatg acacagacac caccgtgtac     4260

tccagtgagg aagcagaact tttaaagctg atagagattg gagtgcaaac cggtagcaca     4320

gcccagattc tccagcctga ctcggggacc acactgagct ctcctcctgt ttaaaaggaa     4380

gcatccacac cccaactccc ggacatcaca tgagaggtct gctcagattt tgaagtgttg     4440

ttctttccac cagcaggaag tagccgcatt tgattttcat ttcgacaaca gaaaaaggac     4500

ctcggactgc agggagccag tcttctaggc atatcctgga agaggcttgt gacccaagaa     4560

tgtgtctgtg tcttctccca gtgttgacct gatcctcttt tttcattcat ttaaaaagca     4620

ttatcatgcc cctgctgcgg gtctcaccat gggtttagaa caaagagctt caagcaatgg     4680

ccccatcctc aaagaagtag cagtacctgg ggagctgaca cttctgtaaa actagaagat     4740

aaaccaggca acgtaagtgt tcgaggtgtt gaagatggga aggatttgca gggctgagtc     4800

tatccaagag gctttgttta ggacgtgggt cccaagccaa gccttaagtg tggaattcgg     4860

attgatagaa aggaagacta acgttacctt gctttggaga gtactggagc ctgcaaatgc     4920

attgtgtttg ctctggtgga ggtgggcatg gggtctgttc tgaaatgtaa agggttcaga     4980

cggggtttct ggttttagaa ggttgcgtgt tcttcgagtt gggctaaagt agagttcgtt     5040

gtgctgtttc tgactcctaa tgagagttcc ttccagaccg ttagctgtct ccttgccaag     5100

ccccaggaag aaaatgatgc agctctggct ccttgtctcc caggctgatc ctttattcag     5160

aataccacaa agaaaggaca ttcagctcaa ggctccctgc cgtgttgaag agttctgact     5220

gcacaaacca gcttctggtt tcttctggaa tgaataccct catatctgtc ctgatgtgat     5280

atgtctgaga ctgaatgcgg gaggttcaat gtgaagctgt gtgtggtgtc aaagtttcag     5340

gaaggatttt acccttttgt tcttccccct gtccccaacc cactctcacc ccgcaaccca     5400

tcagtatttt agttatttgg cctctactcc agtaaacctg attgggtttg ttcactctct     5460

gaatgattat tagccagact tcaaaattat tttatagccc aaattataac atctattgta     5520

ttatttagac ttttaacata tagagctatt tctactgatt tttgcccttg ttctgtcctt     5580

tttttcaaaa aagaaaatgt gttttttgtt tggtaccata gtgtgaaatg ctgggaacaa     5640

tgactataag acatgctatg gcacatatat ttatagtctg tttatgtaga aacaaatgta     5700

atatattaaa gccttatata taatgaactt tgtactattc acattttgta tcagtattat     5760

gtagcataac aaaggtcata atgctttcag caattgatgt cattttatta aagaacattg     5820

aaaaacttga                                                            5830


<210>  17
<211>  1356
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  KDR (VEGF-R2) Receptor protein

<400>  17

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  18
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence encoding recombinant fusion protein

<400>  18
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatctg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      120

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      180

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      240

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      300

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aacccagccc      360

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc      420

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc      480

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc      540

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc      600

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg      660

tctccgggta aatag                                                       675


<210>  19
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant fusion protein

<400>  19

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Gly Arg Pro Phe Val Glu Met Tyr Ser 
            20                  25                  30          


Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile 
        35                  40                  45              


Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe 
    50                  55                  60                  


Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser 
65                  70                  75                  80  


Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr 
            100                 105                 110         


Leu Thr His Arg Gln Thr Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  20
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence encoding recombinant fusion protein

<400>  20
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatctg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      120

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      180

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      240

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      300

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccccttcc      360

tgtgtgcccc tgatgcgatg cgggggctgc tgcaatcagc cccgagaacc acaggtgtac      420

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc      480

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      540

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag      600

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat      660

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatag         717


<210>  21
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant fusion protein

<400>  21

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Gly Arg Pro Phe Val Glu Met Tyr Ser 
            20                  25                  30          


Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile 
        35                  40                  45              


Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe 
    50                  55                  60                  


Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser 
65                  70                  75                  80  


Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr 
            100                 105                 110         


Leu Thr His Arg Gln Thr Pro Ser Cys Val Pro Leu Met Arg Cys Gly 
        115                 120                 125             


Gly Cys Cys Asn Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235             


<210>  22
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence encoding recombinant fusion protein

<400>  22
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatctg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      120

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      180

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      240

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      300

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccggtgga      360

ggtggaggtg gaggtggagg tcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggtaaat ag                         702


<210>  23
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant fusion protein

<400>  23

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Gly Arg Pro Phe Val Glu Met Tyr Ser 
            20                  25                  30          


Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile 
        35                  40                  45              


Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe 
    50                  55                  60                  


Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser 
65                  70                  75                  80  


Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr 
            100                 105                 110         


Leu Thr His Arg Gln Thr Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  24
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence encoding recombinant fusion protein

<400>  24
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatctg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      120

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      180

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      240

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      300

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccggtgga      360

ggtggatcgg gtggaggtgg atcgggtgga ggtggatcgc ctaagagctg cgacaaaact      420

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      480

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      540

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      600

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      660

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      720

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc      780

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc      840

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc      900

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc      960

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1020

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1080

tctccgggta aatag                                                      1095


<210>  25
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant fusion protein

<400>  25

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Gly Arg Pro Phe Val Glu Met Tyr Ser 
            20                  25                  30          


Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile 
        35                  40                  45              


Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe 
    50                  55                  60                  


Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser 
65                  70                  75                  80  


Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr 
            100                 105                 110         


Leu Thr His Arg Gln Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    130                 135                 140                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                165                 170                 175     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            180                 185                 190         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        195                 200                 205             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    210                 215                 220                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
225                 230                 235                 240 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                245                 250                 255     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            260                 265                 270         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        275                 280                 285             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    290                 295                 300                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
305                 310                 315                 320 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                325                 330                 335     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            340                 345                 350         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker of fusion protein

<400>  26

Gly Asp Leu Ile Tyr Arg Asn Gln Lys 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker moiety for fusion proteins

<400>  27

Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker moiety for fusion proteins

<400>  28

Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker moiety for fusion proteins

<400>  29

Ser Ser Ser Ser Ser Ser Ser Ser Ser 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker moiety for fusion proteins

<400>  30

Gly Gly Gly Gly Gly Cys Pro Pro Cys 
1               5                   


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker moiety for fusion proteins

<400>  31

Gly Gly Gly Gly Ser Ser Ser 
1               5           


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker moiety for fusion proteins

<400>  32

Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
1               5                   10              


<210>  33
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker moiety for fusion proteins

<400>  33

Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro Ser Cys Val Pro Leu Met 
1               5                   10                  15      


Arg Cys Gly Gly Cys Cys Asn 
            20              


