                         SEQUENCE LISTING

<110>  Hvidovre hospital
       Gottwein, Judith   M.
       Scheel, Troels  K. H
       Bertelsen Jensen, Tanja
       Bukh, Jens
 
<120>  Efficient cell culture system for hepatitis C virus genotype 7a

<130>  P44620PC01

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  9678
<212>  DNA
<213>  Hepatitis C virus

<400>  1
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacga atcctaaacc      360

tcaaagatta accaaaagaa acaccgtccg tcgcccacag aacgttaagt tcccgggtgg      420

cgggcagatc gttggcggag tctacttgtt gccgcgcagg ggccctagat tgggtgtgcg      480

cggcactagg aagagttcgg agcgatcgca gcccagggga agacgccaac gtatccccaa      540

agctgcctct tcacagggta aagcctgggg caagcccggg tacccttggc ccctgtatgg      600

taacgagggc tgtggctggg cagggtggct cctgtccccc cgcggctctc gacctacttg      660

gggccccact gacccccggc accgctcgcg aaacctcggt aaggtgatcg acaccatgac      720

ctgcgggttt gccgacctca tggggtacat ccctgtccta ggcgcccccc tagggggcgt      780

tgccagggct ctggcacatg gtgttagagt tctggaggac ggggtcaact atgcaacagg      840

gaacttgcct ggttgctcct tttctatctt cttactagcc ctcctgtcat gtctaacagt      900

cccggcatcg gcttatgaag tccgcaactc cagtggggtc tatcatctca ccaatgactg      960

ccccaacgct agtatagtct atgaaacaga caacgccatc ctacacgagc ctgggtgcgt     1020

gccttgcgtt cgcgagggta atactagcag gtgttgggaa ccagtggccc ccactttggc     1080

ggtccgctat cgcggagcgc ttactgacga tttgcggacg catattgacc tagtggtggc     1140

gtcagctacc ctgtgctccg ccttgtacgt gggggacatt tgtggagcca tcttcattgc     1200

cagccaagct gttctctgga agcccggggg gggtcggata gtgcaagatt gcaattgttc     1260

gatctacccg ggccacgtca ccggccacag gatggcgtgg gacatgatgc agaactgggc     1320

gccggccttg tcaatggttg ccgcttacgc tgtgagagtg cccggtgtca tcattaccac     1380

tgtagcgggc ggccactggg gtgtgttatt tggcctcgct tactttggta tggcgggaaa     1440

ctgggcaaag gtaatactca tcatgctact catgtccggc gtcgacgcgg aaaccatggc     1500

cgtcggggct agggccgctc acaccactgg cgcccttgtc agcctgctca atccagggcc     1560

cagtcagcgc ctgcagctga tcaacaccaa tgggtcatgg cacatcaacc ggaccgcttt     1620

gaactgcaat gactctttgc agacagggtt catagcggcc ctcttctaca cacataggtt     1680

caattctagt ggctgtcccg agaggatggc ttcttgtaaa cctctcagtg actttgacca     1740

ggggtggggc ccgctgtggt acaattcaac agaaagacct tcggaccagc gaccctattg     1800

ctggcactac gcgccatcgc cgtgtggtat tgtgccggct aaggatgttt gcggtccggt     1860

ctactgcttt acaccaagcc cggttgtggt gggcaccacg gatcgccggg gggtgcccac     1920

gtatacttgg ggtgaaaatg agtctgatgt cttcctgctc aacagcacaa ggccgccgca     1980

aggcagttgg tttgggtgct catggatgaa cacaacgggg ttcacgaaga cctgcggagg     2040

tcctccgtgc aagatacgtc cccagggtgc ccagagtaac acctctctca cttgtcccac     2100

agactgcttc aggaaacatc cgcgtgccac atactccgct tgcggatctg gtccgtggtt     2160

gacacctaga tgcatggtcc attaccccta tagactgtgg cactacccgt gtacagtcaa     2220

cttcaccata cacaaagtca ggttatacat agggggtgta gaacataggc tcgatgcagc     2280

gtgcaattgg acgcggggtg agcgatgcga cctggaggac cgagacaggg tggacatgtc     2340

ccccctgctc cattccacta cggagctcgc aatacttccg tgttcctttg tgccgcttcc     2400

ggccttatct acgggactga tccacctgca ccaaaacatc gttgacgccc agtaccttta     2460

tggtctttct cccgctataa taagctgggc catcagatgg gagtgggtag tcctcgtttt     2520

cctactcctg gcggacgcgc ggatctgcgc ctgcctttgg atgatgatgc ttatggccca     2580

ggctgaagcc gctctggaga acttgatcca cctcaacgcg gccagccttg cgggaaccca     2640

tggtatctgg tggctccttt tagtcttttg tgcctcttgg catctacgag gcagggttgt     2700

ccctctggtg acgtatggga tatgcgggat gtggcccttc ttcctcatgt tgctgagcct     2760

ccccccacga gcgtatgctc tggacaggga agtgagcgca gcgttgggaa cgggcatgct     2820

cgccatcatc ctattagtta ccttgggacc gcactacaag agacttctag cccttattct     2880

ctggtgggtc acatatttcc ttacaaggtg tgaagcagca ctccaaacgt gggtccctcc     2940

tctcaaccct cgggggggca gggacggttt catcctgtgt gtgctgctgt gctatccagg     3000

ccttgtcttt gacatcacaa aatggttgct ggtcatgatg tgccctctct acctcctcca     3060

gttgtgtttg gtgaggactc catactttgt gagggcccag gccctcatca gagtgtgttc     3120

tctcttcaaa acgctagctg ggggacggta cgtgcaggcc gcgctgctca ctattggccg     3180

ctggaccggc acttatattt ataaccatct cgcccccctg gaaacatggg ccgccggcgg     3240

cctacgggat ttggccgttg cagtcgagcc cgtgatattc tcccccatgg agaagaagat     3300

catagtttgg ggggcggaga ccactgcttg tggcgacatt ctttgtggcc tgcctgtctc     3360

agctcggctc ggcagggaag tcctgctagg gcccgcggat gactacaggt ccatgggatg     3420

gcaactcctg gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgctc cggatcctgg ctccgcgacg tgtgggactg     6300

ggtttgcacc atcttgacag acttcaaaaa ttggctgacc tctaaattgt tccccaagct     6360

gcccggcctc cccttcatct cttgtcaaaa ggggtacaag ggtgtgtggg ccggcactgg     6420

catcatgacc acgcgctgcc cttgcggcgc caacatctct ggcaatgtcc gcctgggctc     6480

tatgaggatc acagggccta aaacctgcat gaacacctgg caggggacct ttcctatcaa     6540

ttgctacacg gagggccagt gcgcgccgaa accccccacg aactacaaga ccgccatctg     6600

gagggtggcg gcctcggagt acgcggaggt gacgcagcat gggtcgtact cctatgtaac     6660

aggactgacc actgacaatc tgaaaattcc ttgccaacta ccttctccag agtttttctc     6720

ctgggtggac ggtgtgcaga tccataggtt tgcacccaca ccaaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc ctatgctgtc gggtcccagc ttccctgtga     6840

acctgagccc gacgcagacg tattgaggtc catgctaaca gatccgcccc acatcacggc     6900

ggagactgcg gcgcggcgct tggcacgggg atcacctcca tctgaggcga gctcctcagt     6960

gagccagcta tcagcaccgt cgctgcgggc cacctgcacc acccacagca acacctatga     7020

cgtggacatg gtcgatgcca acctgctcat ggagggcggt gtggctcaga cagagcctga     7080

gtccagggtg cccgttctgg actttctcga gccaatggcc gaggaagaga gcgaccttga     7140

gccctcaata ccatcggagt gcatgctccc caggagcggg tttccacggg ccttaccggc     7200

ttgggcacgg cctgactaca acccgccgct cgtggaatcg tggaggaggc cagattacca     7260

accgcccacc gttgctggtt gtgctctccc cccccccaag aaggccccga cgcctccccc     7320

aaggagacgc cggacagtgg gtctgagcga gagcaccata tcagaagccc tccagcaact     7380

ggccatcaag acctttggcc agcccccctc gagcggtgat gcaggctcgt ccacgggggc     7440

gggcgccgcc gaatccggcg gtccgacgtc ccctggtgag ccggccccct cagagacagg     7500

ttccgcctcc tctatgcccc ccctcgaggg ggagcctgga gatccggacc tggagtctga     7560

tcaggtagag cttcaacctc ccccccaggg ggggggggta gctcccggtt cgggctcggg     7620

gtcttggtct acttgctccg aggaggacga taccaccgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccctgtag ccccgaagag gaaaagttgc caatcaaccc     7740

tttgagtaac tcgctgttgc gataccataa caaggtgtac tgtacaacat caaagagcgc     7800

ctcacagagg gctaaaaagg taacttttga caggacgcaa gtgctcgacg cccattatga     7860

ctcagtctta aaggacatca agctagcggc ttccaaggtc agcgcaaggc tcctcacctt     7920

ggaggaggcg tgccagttga ctccacccca ttctgcaaga tccaagtatg gattcggggc     7980

caaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggaa gacccacaaa caccaattcc cacaaccatc atggccaaaa atgaggtgtt     8100

ctgcgtggac cccgccaagg ggggtaagaa accagctcgc ctcatcgttt accctgacct     8160

cggcgtccgg gtctgcgaga aaatggccct ctatgacatt acacaaaagc ttcctcaggc     8220

ggtaatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg ccatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  2
<211>  3033
<212>  PRT
<213>  Hepatitis C virus

<400>  2

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Asn Leu Ile His Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly 
        755                 760                 765             


Ile Trp Trp Leu Leu Leu Val Phe Cys Ala Ser Trp His Leu Arg Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Val Thr Tyr Gly Ile Cys Gly Met Trp Pro Phe 
785                 790                 795                 800 


Phe Leu Met Leu Leu Ser Leu Pro Pro Arg Ala Tyr Ala Leu Asp Arg 
                805                 810                 815     


Glu Val Ser Ala Ala Leu Gly Thr Gly Met Leu Ala Ile Ile Leu Leu 
            820                 825                 830         


Val Thr Leu Gly Pro His Tyr Lys Arg Leu Leu Ala Leu Ile Leu Trp 
        835                 840                 845             


Trp Val Thr Tyr Phe Leu Thr Arg Cys Glu Ala Ala Leu Gln Thr Trp 
    850                 855                 860                 


Val Pro Pro Leu Asn Pro Arg Gly Gly Arg Asp Gly Phe Ile Leu Cys 
865                 870                 875                 880 


Val Leu Leu Cys Tyr Pro Gly Leu Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Val Met Met Cys Pro Leu Tyr Leu Leu Gln Leu Cys Leu Val Arg 
            900                 905                 910         


Thr Pro Tyr Phe Val Arg Ala Gln Ala Leu Ile Arg Val Cys Ser Leu 
        915                 920                 925             


Phe Lys Thr Leu Ala Gly Gly Arg Tyr Val Gln Ala Ala Leu Leu Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asn His Leu Ala Pro Leu 
945                 950                 955                 960 


Glu Thr Trp Ala Ala Gly Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Val Ile Phe Ser Pro Met Glu Lys Lys Ile Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Thr Ala Cys Gly Asp Ile  Leu Cys Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Asp Tyr Arg 
    1010                 1015                 1020             


Ser Met  Gly Trp Gln Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Ser Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Leu Pro Gly Leu  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Thr Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Ala  Pro Lys Pro Pro Thr  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Ile Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Tyr Ala Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Ala Asp Val Leu  Arg Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Pro His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Val Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Ser 
    2210                 2215                 2220             


Asn Thr  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Leu Met Glu 
    2225                 2230                 2235             


Gly Gly  Val Ala Gln Thr Glu  Pro Glu Ser Arg Val  Pro Val Leu 
    2240                 2245                 2250             


Asp Phe  Leu Glu Pro Met Ala  Glu Glu Glu Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Cys Met  Leu Pro Arg Ser Gly  Phe Pro Arg 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Arg Arg Pro Asp  Tyr Gln Pro Pro Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Lys  Lys Ala Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Ser Thr Ile  Ser Glu Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Thr Phe Gly Gln Pro  Pro Ser Ser 
    2345                 2350                 2355             


Gly Asp  Ala Gly Ser Ser Thr  Gly Ala Gly Ala Ala  Glu Ser Gly 
    2360                 2365                 2370             


Gly Pro  Thr Ser Pro Gly Glu  Pro Ala Pro Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ala Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Ser Asp Gln Val Glu  Leu Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Gly Val  Ala Pro Gly Ser Gly  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Thr Thr Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Ser Lys  Ser Ala Ser Gln Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Thr Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Leu Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Pro Gln Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Ala Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  3
<211>  9678
<212>  DNA
<213>  Hepatitis C virus

<400>  3
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacga atcctaaacc      360

tcaaagatta accaaaagaa acaccgtccg tcgcccacag aacgttaagt tcccgggtgg      420

cgggcagatc gttggcggag tctacttgtt gccgcgcagg ggccctagat tgggtgtgcg      480

cggcactagg aagagttcgg agcgatcgca gcccagggga agacgccaac gtatccccaa      540

agctgcctct tcacagggta aagcctgggg caagcccggg tacccttggc ccctgtatgg      600

taacgagggc tgtggctggg cagggtggct cctgtccccc cgcggctctc gacctacttg      660

gggccccact gacccccggc accgctcgcg aaacctcggt aaggtgatcg acaccatgac      720

ctgcgggttt gccgacctca tggggtacat ccctgtccta ggcgcccccc tagggggcgt      780

tgccagggct ctggcacatg gtgttagatt tctggaggac ggggtcaact atgcaacagg      840

gaacttgcct ggttgctcct tttctatctt cttactagcc ctcctgtcat gtctaacagt      900

cccggcatcg gcttatgaag tccgcaactc cagtggggtc tatcatctca ccaatgactg      960

ccccaacgct agtatagtct atgaaacaga caacgccatc ctacacgagc ctgggtgcgt     1020

gccttgcgtt cgcgagggta atactagcag gtgttgggaa ccagtggccc ccactttggc     1080

ggtccgctat cgcggagcgc ttactgacga tttgcggacg catattgacc tagtggtggc     1140

gtcagctacc ctgtgctccg ccttgtacgt gggggacatt tgtggagcca tcttcattgc     1200

cagccaagct gttctctgga agcccggggg gggtcggata gtgcaagatt gcaattgttc     1260

gatctacccg ggccacgtca ccggccacag gatggcgtgg gacatgatgc agaactgggc     1320

gccggccttg tcaatggttg ccgcttacgc tgtgagagtg cccggtgtca tcattaccac     1380

tgtagcgggc ggccactggg gtgtgttatt tggcctcgct tactttggta tggcgggaaa     1440

ctgggcaaag gtaatactca tcatgctact catgtccggc gtcgacgcgg aaaccatggc     1500

cgtcggggct agggccgctc acaccactgg cgcccttgtc agcctgctca atccagggcc     1560

cagtcagcgc ctgcagctga tcaacaccaa tgggtcatgg cacatcaacc ggaccgcttt     1620

gaactgcaat gactctttgc agacagggtt catagcggcc ctcttctaca cacataggtt     1680

caattctagt ggctgtcccg agaggatggc ttcttgtaaa cctctcagtg actttgacca     1740

ggggtggggc ccgctgtggt acaattcaac agaaagacct tcggaccagc gaccctattg     1800

ctggcactac gcgccatcgc cgtgtggtat tgtgccggct aaggatgttt gcggtccggt     1860

ctactgcttt acaccaagcc cggttgtggt gggcaccacg gatcgccggg gggtgcccac     1920

gtatacttgg ggtgaaaatg agtctgatgt cttcctgctc aacagcacaa ggccgccgca     1980

aggcagttgg tttgggtgct catggatgaa cacaacgggg ttcacgaaga cctgcggagg     2040

tcctccgtgc aagatacgtc cccagggtgc ccagagtaac acctctctca cttgtcccac     2100

agactgcttc aggaaacatc cgcgtgccac atactccgct tgcggatctg gtccgtggtt     2160

gacacctaga tgcatggtcc attaccccta tagactgtgg cactacccgt gtacagtcaa     2220

cttcaccata cacaaagtca ggttatacat agggggtgta gaacataggc tcgatgcagc     2280

gtgcaattgg acgcggggtg agcgatgcga cctggaggac cgagacaggg tggacatgtc     2340

ccccctgctc cattccacta cggagctcgc aatacttccg tgttcctttg tgccgcttcc     2400

ggccttatct acgggactga tccacctgca ccaaaacatc gttgacgccc agtaccttta     2460

tggtctttct cccgctataa taagctgggc catcagatgg gagtgggtag tcctcgtttt     2520

cctactcctg gcggacgcgc ggatctgcgc ctgcctttgg atgatgatgc ttatggccca     2580

ggctgaagcc gctctggaga acttgatcca cctcaacgcg gccagccttg cgggaaccca     2640

tggtatctgg tggctccttt tagtcttttg tgcctcttgg catctacgag gcagggttgt     2700

ccctctggtg acgtatggga tatgcgggat gtggcccttc ttcctcatgt tgctgagcct     2760

ccccccacga gcgtatgctc tggacaggga agtgagcgca gcgttgggaa cgggcatgct     2820

cgccatcatc ctattagtta ccttgggacc gcactacaag agacttctag cccttattct     2880

ctggtgggtc acatatttcc ttacaaggtg tgaagcagca ctccaaacgt gggtccctcc     2940

tctcaaccct cgggggggca gggacggttt catcctgtgt gtgctgctgt gctatccagg     3000

ccttgtcttt gacatcacaa aatggttgct ggtcatgatg tgccctctct acctcctcca     3060

gttgtgtttg gtgaggactc catactttgt gagggcccag gccctcatca gagtgtgttc     3120

tctcttcaaa acgctagctg ggggacggta cgtgcaggcc gcgctgctca ctattggccg     3180

ctggaccggc acttatattt ataaccatct cgcccccctg gaaacatggg ccgccggcgg     3240

cctacgggat ttggccgttg cagtcgagcc cgtgatattc tcccccatgg agaagaagat     3300

catagtttgg ggggcggaga ccactgcttg tggcgacatt ctttgtggcc tgcctgtctc     3360

agctcggctc ggcagggaag tcctgctagg gcccgcggat gactacaggt ccatgggatg     3420

gcaactcctg gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgctc cggatcctgg ctccgcgacg tgtgggactg     6300

ggtttgcacc atcttgacag acttcaaaaa ttggctgacc tctaaattgt tccccaagct     6360

gcccggcctc cccttcatct cttgtcaaaa ggggtacaag ggtgtgtggg ccggcactgg     6420

catcatgacc acgcgctgcc cttgcggcgc caacatctct ggcaatgtcc gcctgggctc     6480

tatgaggatc acagggccta aaacctgcat gaacacctgg caggggacct ttcctatcaa     6540

ttgctacacg gagggccagt gcgcgccgaa accccccacg aactacaaga ccgccatctg     6600

gagggtggcg gcctcggagt acgcggaggt gacgcagcat gggtcgtact cctatgtaac     6660

aggactgacc actgacaatc tgaaaattcc ttgccaacta ccttctccag agtttttctc     6720

ctgggtggac ggtgtgcaga tccataggtt tgcacccaca ccaaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc ctatgctgtc gggtcccagc ttccctgtga     6840

acctgagccc gacgcagacg tattgaggtc catgctaaca gatccgcccc acatcacggc     6900

ggagactgcg gcgcggcgct tggcacgggg atcacctcca tctgaggcga gctcctcagt     6960

gagccagcta tcagcaccgt cgctgcgggc cacctgcacc acccacagca acacctatga     7020

cgtggacatg gtcgatgcca acctgctcat ggagggcggt gtggctcaga cagagcctga     7080

gtccagggtg cccgttctgg actttctcga gccaatggcc gaggaagaga gcgaccttga     7140

gccctcaata ccatcggagt gcatgctccc caggagcggg tttccacggg ccttaccggc     7200

ttgggcacgg cctgactaca acccgccgct cgtggaatcg tggaggaggc cagattacca     7260

accgcccacc gttgctggtt gtgctctccc cccccccaag aaggccccga cgcctccccc     7320

aaggagacgc cggacagtgg gtctgagcga gagcaccata tcagaagccc tccagcaact     7380

ggccatcaag acctttggcc agcccccctc gagcggtgat gcaggctcgt ccacgggggc     7440

gggcgccgcc gaatccggcg gtccgacgtc ccctggtgag ccggccccct cagagacagg     7500

ttccgcctcc tctatgcccc ccctcgaggg ggagcctgga gatccggacc tggagtctga     7560

tcaggtagag cttcaacctc ccccccaggg ggggggggta gctcccggtt cgggctcggg     7620

gtcttggtct acttgctccg aggaggacga taccaccgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccctgtag ccccgaagag gaaaagttgc caatcaaccc     7740

tttgagtaac tcgctgttgc gataccataa caaggtgtac tgtacaacat caaagagcgc     7800

ctcacagagg gctaaaaagg taacttttga caggacgcaa gtgctcgacg cccattatga     7860

ctcagtctta aaggacatca agctagcggc ttccaaggtc agcgcaaggc tcctcacctt     7920

ggaggaggcg tgccagttga ctccacccca ttctgcaaga tccaagtatg gattcggggc     7980

caaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggaa gacccacaaa caccaattcc cacaaccatc atggccaaaa atgaggtgtt     8100

ctgcgtggac cccgccaagg ggggtaagaa accagctcgc ctcatcgttt accctgacct     8160

cggcgtccgg gtctgcgaga aaatggccct ctatgacatt acacaaaagc ttcctcaggc     8220

ggtaatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg ccatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  4
<211>  3033
<212>  PRT
<213>  Hepatitis C virus

<400>  4

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Phe Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Asn Leu Ile His Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly 
        755                 760                 765             


Ile Trp Trp Leu Leu Leu Val Phe Cys Ala Ser Trp His Leu Arg Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Val Thr Tyr Gly Ile Cys Gly Met Trp Pro Phe 
785                 790                 795                 800 


Phe Leu Met Leu Leu Ser Leu Pro Pro Arg Ala Tyr Ala Leu Asp Arg 
                805                 810                 815     


Glu Val Ser Ala Ala Leu Gly Thr Gly Met Leu Ala Ile Ile Leu Leu 
            820                 825                 830         


Val Thr Leu Gly Pro His Tyr Lys Arg Leu Leu Ala Leu Ile Leu Trp 
        835                 840                 845             


Trp Val Thr Tyr Phe Leu Thr Arg Cys Glu Ala Ala Leu Gln Thr Trp 
    850                 855                 860                 


Val Pro Pro Leu Asn Pro Arg Gly Gly Arg Asp Gly Phe Ile Leu Cys 
865                 870                 875                 880 


Val Leu Leu Cys Tyr Pro Gly Leu Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Val Met Met Cys Pro Leu Tyr Leu Leu Gln Leu Cys Leu Val Arg 
            900                 905                 910         


Thr Pro Tyr Phe Val Arg Ala Gln Ala Leu Ile Arg Val Cys Ser Leu 
        915                 920                 925             


Phe Lys Thr Leu Ala Gly Gly Arg Tyr Val Gln Ala Ala Leu Leu Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asn His Leu Ala Pro Leu 
945                 950                 955                 960 


Glu Thr Trp Ala Ala Gly Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Val Ile Phe Ser Pro Met Glu Lys Lys Ile Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Thr Ala Cys Gly Asp Ile  Leu Cys Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Asp Tyr Arg 
    1010                 1015                 1020             


Ser Met  Gly Trp Gln Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Ser Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Leu Pro Gly Leu  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Thr Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Ala  Pro Lys Pro Pro Thr  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Ile Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Tyr Ala Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Ala Asp Val Leu  Arg Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Pro His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Val Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Ser 
    2210                 2215                 2220             


Asn Thr  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Leu Met Glu 
    2225                 2230                 2235             


Gly Gly  Val Ala Gln Thr Glu  Pro Glu Ser Arg Val  Pro Val Leu 
    2240                 2245                 2250             


Asp Phe  Leu Glu Pro Met Ala  Glu Glu Glu Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Cys Met  Leu Pro Arg Ser Gly  Phe Pro Arg 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Arg Arg Pro Asp  Tyr Gln Pro Pro Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Lys  Lys Ala Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Ser Thr Ile  Ser Glu Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Thr Phe Gly Gln Pro  Pro Ser Ser 
    2345                 2350                 2355             


Gly Asp  Ala Gly Ser Ser Thr  Gly Ala Gly Ala Ala  Glu Ser Gly 
    2360                 2365                 2370             


Gly Pro  Thr Ser Pro Gly Glu  Pro Ala Pro Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ala Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Ser Asp Gln Val Glu  Leu Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Gly Val  Ala Pro Gly Ser Gly  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Thr Thr Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Ser Lys  Ser Ala Ser Gln Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Thr Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Leu Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Pro Gln Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Ala Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  5
<211>  9678
<212>  DNA
<213>  Hepatitis C virus

<400>  5
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacga atcctaaacc      360

tcaaagatta accaaaagaa acaccgtccg tcgcccacag aacgttaagt tcccgggtgg      420

cgggcagatc gttggcggag tctacttgtt gccgcgcagg ggccctagat tgggtgtgcg      480

cggcactagg aagagttcgg agcgatcgca gcccagggga agacgccaac gtatccccaa      540

agctgcctct tcacagggta aagcctgggg caagcccggg tacccttggc ccctgtatgg      600

taacgagggc tgtggctggg cagggtggct cctgtccccc cgcggctctc gacctacttg      660

gggccccact gacccccggc accgctcgcg aaacctcggt aaggtgatcg acaccatgac      720

ctgcgggttt gccgacctca tggggtacat ccctgtccta ggcgcccccc tagggggcgt      780

tgccagggct ctggcacatg gtgttagagt tctggaggac ggggtcaact atgcaacagg      840

gaacttgcct ggttgctcct tttctatctt cttactagcc ctcctgtcat gtctaacagt      900

cccggcatcg gcttatgaag tccgcaactc cagtggggtc tatcatctca ccaatgactg      960

ccccaacgct agtatagtct atgaaacaga caacgccatc ctacacgagc ctgggtgcgt     1020

gccttgcgtt cgcgagggta atactagcag gtgttgggaa ccagtggccc ccactttggc     1080

ggtccgctat cgcggagcgc ttactgacga tttgcggacg catattgacc tagtggtggc     1140

gtcagctacc ctgtgctccg ccttgtacgt gggggacatt tgtggagcca tcttcattgc     1200

cagccaagct gttctctgga agcccggggg gggtcggata gtgcaagatt gcaattgttc     1260

gatctacccg ggccacgtca ccggccacag gatggcgtgg gacatgatgc agaactgggc     1320

gccggccttg tcaatggttg ccgcttacgc tgtgagagtg cccggtgtca tcattaccac     1380

tgtagcgggc ggccactggg gtgtgttatt tggcctcgct tactttggta tggcgggaaa     1440

ctgggcaaag gtaatactca tcatgctact catgtccggc gtcgacgcgg aaaccatggc     1500

cgtcggggct agggccgctc acaccactgg cgcccttgtc agcctgctca atccagggcc     1560

cagtcagcgc ctgcagctga ccaacaccaa tgggtcatgg cacatcaacc ggaccgcttt     1620

gaactgcaat gactctttgc agacagggtt catagcggcc ctcttctaca cacataggtt     1680

caattctagt ggctgtcccg agaggatggc ttcttgtaaa cctctcagtg actttgacca     1740

ggggtggggc ccgctgtggt acaattcaac agaaagacct tcggaccagc gaccctattg     1800

ctggcactac gcgccatcgc cgtgtggtat tgtgccggct aaggatgttt gcggtccggt     1860

ctactgcttt acaccaagcc cggttgtggt gggcaccacg gatcgccggg gggtgcccac     1920

gtatacttgg ggtgaaaatg agtctgatgt cttcctgctc aacagcacaa ggccgccgca     1980

aggcagttgg tttgggtgct catggatgaa cacaacgggg ttcacgaaga cctgcggagg     2040

tcctccgtgc aagatacgtc cccagggtgc ccagagtaac acctctctca cttgtcccac     2100

agactgcttc aggaaacatc cgcgtgccac atactccgct tgcggatctg gtccgtggtt     2160

gacacctaga tgcatggtcc attaccccta tagactgtgg cactacccgt gtacagtcaa     2220

cttcaccata cacaaagtca ggttatacat agggggtgta gaacataggc tcgatgcagc     2280

gtgcaattgg acgcggggtg agcgatgcga cctggaggac cgagacaggg tggacatgtc     2340

ccccctgctc cattccacta cggagctcgc aatacttccg tgttcctttg tgccgcttcc     2400

ggccttatct acgggactga tccacctgca ccaaaacatc gttgacgccc agtaccttta     2460

tggtctttct cccgctataa taagctgggc catcagatgg gagtgggtag tcctcgtttt     2520

cctactcctg gcggacgcgc ggatctgcgc ctgcctttgg atgatgatgc ttatggccca     2580

ggctgaagcc gctctggaga acttgatcca cctcaacgcg gccagccttg cgggaaccca     2640

tggtatctgg tggctccttt tagtcttttg tgcctcttgg catctacgag gcagggttgt     2700

ccctctggtg acgtatggga tatgcgggat gtggcccttc ttcctcatgt tgctgagcct     2760

ccccccacga gcgtatgctc tggacaggga agtgagcgca gcgttgggaa cgggcatgct     2820

cgccatcatc ctattagtta ccttgggacc gcactacaag agacttctag cccttattct     2880

ctggtgggtc acatatttcc ttacaaggtg tgaagcagca ctccaaacgt gggtccctcc     2940

tctcaaccct cgggggggca gggacggttt catcctgtgt gtgctgctgt gctatccagg     3000

ccttgtcttt gacatcacaa aatggttgct ggtcatgatg tgccctctct acctcctcca     3060

gttgtgtttg gtgaggactc catactttgt gagggcccag gccctcatca gagtgtgttc     3120

tctcttcaaa acgctagctg ggggacggta cgtgcaggcc gcgctgctca ctattggccg     3180

ctggaccggc acttatattt ataaccatct cgcccccctg gaaacatggg ccgccggcgg     3240

cctacgggat ttggccgttg cagtcgagcc cgtgatattc tcccccatgg agaagaagat     3300

catagtttgg ggggcggaga ccactgcttg tggcgacatt ctttgtggcc tgcctgtctc     3360

agctcggctc ggcagggaag tcctgctagg gcccgcggat gactacaggt ccatgggatg     3420

gcaactcctg gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgctc cggatcctgg ctccgcgacg tgtgggactg     6300

ggtttgcacc atcttgacag acttcaaaaa ttggctgacc tctaaattgt tccccaagct     6360

gcccggcctc cccttcatct cttgtcaaaa ggggtacaag ggtgtgtggg ccggcactgg     6420

catcatgacc acgcgctgcc cttgcggcgc caacatctct ggcaatgtcc gcctgggctc     6480

tatgaggatc acagggccta aaacctgcat gaacacctgg caggggacct ttcctatcaa     6540

ttgctacacg gagggccagt gcgcgccgaa accccccacg aactacaaga ccgccatctg     6600

gagggtggcg gcctcggagt acgcggaggt gacgcagcat gggtcgtact cctatgtaac     6660

aggactgacc actgacaatc tgaaaattcc ttgccaacta ccttctccag agtttttctc     6720

ctgggtggac ggtgtgcaga tccataggtt tgcacccaca ccaaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc ctatgctgtc gggtcccagc ttccctgtga     6840

acctgagccc gacgcagacg tattgaggtc catgctaaca gatccgcccc acatcacggc     6900

ggagactgcg gcgcggcgct tggcacgggg atcacctcca tctgaggcga gctcctcagt     6960

gagccagcta tcagcaccgt cgctgcgggc cacctgcacc acccacagca acacctatga     7020

cgtggacatg gtcgatgcca acctgctcat ggagggcggt gtggctcaga cagagcctga     7080

gtccagggtg cccgttctgg actttctcga gccaatggcc gaggaagaga gcgaccttga     7140

gccctcaata ccatcggagt gcatgctccc caggagcggg tttccacggg ccttaccggc     7200

ttgggcacgg cctgactaca acccgccgct cgtggaatcg tggaggaggc cagattacca     7260

accgcccacc gttgctggtt gtgctctccc cccccccaag aaggccccga cgcctccccc     7320

aaggagacgc cggacagtgg gtctgagcga gagcaccata tcagaagccc tccagcaact     7380

ggccatcaag acctttggcc agcccccctc gagcggtgat gcaggctcgt ccacgggggc     7440

gggcgccgcc gaatccggcg gtccgacgtc ccctggtgag ccggccccct cagagacagg     7500

ttccgcctcc tctatgcccc ccctcgaggg ggagcctgga gatccggacc tggagtctga     7560

tcaggtagag cttcaacctc ccccccaggg ggggggggta gctcccggtt cgggctcggg     7620

gtcttggtct acttgctccg aggaggacga taccaccgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccctgtag ccccgaagag gaaaagttgc caatcaaccc     7740

tttgagtaac tcgctgttgc gataccataa caaggtgtac tgtacaacat caaagagcgc     7800

ctcacagagg gctaaaaagg taacttttga caggacgcaa gtgctcgacg cccattatga     7860

ctcagtctta aaggacatca agctagcggc ttccaaggtc agcgcaaggc tcctcacctt     7920

ggaggaggcg tgccagttga ctccacccca ttctgcaaga tccaagtatg gattcggggc     7980

caaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggaa gacccacaaa caccaattcc cacaaccatc atggccaaaa atgaggtgtt     8100

ctgcgtggac cccgccaagg ggggtaagaa accagctcgc ctcatcgttt accctgacct     8160

cggcgtccgg gtctgcgaga aaatggccct ctatgacatt acacaaaagc ttcctcaggc     8220

ggtaatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg ccatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  6
<211>  3033
<212>  PRT
<213>  Hepatitis C virus

<400>  6

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Thr Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Asn Leu Ile His Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly 
        755                 760                 765             


Ile Trp Trp Leu Leu Leu Val Phe Cys Ala Ser Trp His Leu Arg Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Val Thr Tyr Gly Ile Cys Gly Met Trp Pro Phe 
785                 790                 795                 800 


Phe Leu Met Leu Leu Ser Leu Pro Pro Arg Ala Tyr Ala Leu Asp Arg 
                805                 810                 815     


Glu Val Ser Ala Ala Leu Gly Thr Gly Met Leu Ala Ile Ile Leu Leu 
            820                 825                 830         


Val Thr Leu Gly Pro His Tyr Lys Arg Leu Leu Ala Leu Ile Leu Trp 
        835                 840                 845             


Trp Val Thr Tyr Phe Leu Thr Arg Cys Glu Ala Ala Leu Gln Thr Trp 
    850                 855                 860                 


Val Pro Pro Leu Asn Pro Arg Gly Gly Arg Asp Gly Phe Ile Leu Cys 
865                 870                 875                 880 


Val Leu Leu Cys Tyr Pro Gly Leu Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Val Met Met Cys Pro Leu Tyr Leu Leu Gln Leu Cys Leu Val Arg 
            900                 905                 910         


Thr Pro Tyr Phe Val Arg Ala Gln Ala Leu Ile Arg Val Cys Ser Leu 
        915                 920                 925             


Phe Lys Thr Leu Ala Gly Gly Arg Tyr Val Gln Ala Ala Leu Leu Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asn His Leu Ala Pro Leu 
945                 950                 955                 960 


Glu Thr Trp Ala Ala Gly Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Val Ile Phe Ser Pro Met Glu Lys Lys Ile Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Thr Ala Cys Gly Asp Ile  Leu Cys Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Asp Tyr Arg 
    1010                 1015                 1020             


Ser Met  Gly Trp Gln Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Ser Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Leu Pro Gly Leu  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Thr Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Ala  Pro Lys Pro Pro Thr  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Ile Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Tyr Ala Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Ala Asp Val Leu  Arg Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Pro His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Val Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Ser 
    2210                 2215                 2220             


Asn Thr  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Leu Met Glu 
    2225                 2230                 2235             


Gly Gly  Val Ala Gln Thr Glu  Pro Glu Ser Arg Val  Pro Val Leu 
    2240                 2245                 2250             


Asp Phe  Leu Glu Pro Met Ala  Glu Glu Glu Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Cys Met  Leu Pro Arg Ser Gly  Phe Pro Arg 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Arg Arg Pro Asp  Tyr Gln Pro Pro Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Lys  Lys Ala Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Ser Thr Ile  Ser Glu Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Thr Phe Gly Gln Pro  Pro Ser Ser 
    2345                 2350                 2355             


Gly Asp  Ala Gly Ser Ser Thr  Gly Ala Gly Ala Ala  Glu Ser Gly 
    2360                 2365                 2370             


Gly Pro  Thr Ser Pro Gly Glu  Pro Ala Pro Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ala Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Ser Asp Gln Val Glu  Leu Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Gly Val  Ala Pro Gly Ser Gly  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Thr Thr Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Ser Lys  Ser Ala Ser Gln Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Thr Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Leu Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Pro Gln Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Ala Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  7
<211>  9678
<212>  DNA
<213>  Hepatitis C virus

<400>  7
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacga atcctaaacc      360

tcaaagatta accaaaagaa acaccgtccg tcgcccacag aacgttaagt tcccgggtgg      420

cgggcagatc gttggcggag tctacttgtt gccgcgcagg ggccctagat tgggtgtgcg      480

cggcactagg aagagttcgg agcgatcgca gcccagggga agacgccaac gtatccccaa      540

agctgcctct tcacagggta aagcctgggg caagcccggg tacccttggc ccctgtatgg      600

taacgagggc tgtggctggg cagggtggct cctgtccccc cgcggctctc gacctacttg      660

gggccccact gacccccggc accgctcgcg aaacctcggt aaggtgatcg acaccatgac      720

ctgcgggttt gccgacctca tggggtacat ccctgtccta ggcgcccccc tagggggcgt      780

tgccagggct ctggcacatg gtgttagagt tctggaggac ggggtcaact atgcaacagg      840

gaacttgcct ggttgctcct tttctatctt cttactagcc ctcctgtcat gtctaacagt      900

cccggcatcg gcttatgaag tccgcaactc cagtggggtc tatcatctca ccaatgactg      960

ccccaacgct agtatagtct atgaaacaga caacgccatc ctacacgagc ctgggtgcgt     1020

gccttgcgtt cgcgagggta atactagcag gtgttgggaa ccagtggccc ccactttggc     1080

ggtccgctat cgcggagcgc ttactgacga tttgcggacg catattgacc tagtggtggc     1140

gtcagctacc ctgtgctccg ccttgtacgt gggggacatt tgtggagcca tcttcattgc     1200

cagccaagct gttctctgga agcccggggg gggtcggata gtgcaagatt gcaattgttc     1260

gatctacccg ggccacgtca ccggccacag gatggcgtgg gacatgatgc agaactgggc     1320

gccggccttg tcaatggttg ccgcttacgc tgtgagagtg cccggtgtca tcattaccac     1380

tgtagcgggc ggccactggg gtgtgttatt tggcctcgct tactttggta tggcgggaaa     1440

ctgggcaaag gtaatactca tcatgctact catgtccggc gtcgacgcgg aaaccatggc     1500

cgtcggggct agggccgctc acaccactgg cgcccttgtc agcctgctca atccagggcc     1560

cagtcagcgc ctgcagctga tcaacaccaa tgggtcatgg cacatcaacc ggaccgcttt     1620

gaactgcaat gactctttgc agacagggtt catagcggcc ctcttctaca cacataggtt     1680

caattctagt ggctgtcccg agaggatggc ttcttgtaaa cctctcagtg actttgacca     1740

ggggtggggc ccgctgtggt acaattcaac agaaagacct tcggaccagc gaccctattg     1800

ctggcactac gcgccatcgc cgtgtggtat tgtgccggct aaggatgttt gcggtccggt     1860

ctactgcttt acaccaagcc cggttgtggt gggcaccacg gatcgccggg gggtgcccac     1920

gtatacttgg ggtgaaaatg agtctgatgt cttcctgctc aacagcacaa ggccgccgca     1980

aggcagttgg tttgggtgct catggatgaa cacaacgggg ttcacgaaga cctgcggagg     2040

tcctccgtgc aagatacgtc cccagggtgc ccagagtaac acctctctca cttgtcccac     2100

agactgcttc aggaaacatc cgcgtgccac atactccgct tgcggatctg gtccgtggtt     2160

gacacctaga tgcatggtcc attaccccta tagactgtgg cactacccgt gtacagtcaa     2220

cttcaccata cacaaagtca ggttatacat agggggtgta gaacataggc tcgatgcagc     2280

gtgcaattgg acgcggggtg agcgatgcga cctggaggac cgagacaggg tggacatgtc     2340

ccccctgctc cattccacta cggagctcgc aatacttccg tgttcctttg tgccgcttcc     2400

ggccttatct acgggactga tccacctgca ccaaaacatc gttgacgccc agtaccttta     2460

tggtctttct cccgctataa taagctgggc catcagatgg gagtgggtag tcctcgtttt     2520

cctactcctg gcggacgcgc ggatctgcgc ctgcctttgg atgatgatgc ttatggccca     2580

ggctgaagcc gctctggaga acttgatcca cctcaacgcg gccagccttg cgggaaccca     2640

tggtatctgg tggctccttt tagtcttttg tgcctcttgg catctacgag gcagggttgt     2700

ccctctggtg acgtatggga tatgcgggat gtggcccttc ttcctcatgt tgctgagcct     2760

ccccccacga gcgtatgctc tggacaggga agtgagcgca gcgttgggaa cgggcatgct     2820

cgccatcatc ctattagtta ccttgggacc gcactacaag agacttctag cccttattct     2880

ctggtgggtc acatatttcc ttacaaggtg tgaagcagca ctccaaacgt gggtccctcc     2940

tctcaaccct cgggggggca gggacggttt catcctgtgt gtgccgctgt gctatccagg     3000

ccttgtcttt gacatcacaa aatggttgct ggtcatgatg tgccctctct acctcctcca     3060

gttgtgtttg gtgaggactc catactttgt gagggcccag gccctcatca gagtgtgttc     3120

tctcttcaaa acgctagctg ggggacggta cgtgcaggcc gcgctgctca ctattggccg     3180

ctggaccggc acttatattt ataaccatct cgcccccctg gaaacatggg ccgccggcgg     3240

cctacgggat ttggccgttg cagtcgagcc cgtgatattc tcccccatgg agaagaagat     3300

catagtttgg ggggcggaga ccactgcttg tggcgacatt ctttgtggcc tgcctgtctc     3360

agctcggctc ggcagggaag tcctgctagg gcccgcggat gactacaggt ccatgggatg     3420

gcaactcctg gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgctc cggatcctgg ctccgcgacg tgtgggactg     6300

ggtttgcacc atcttgacag acttcaaaaa ttggctgacc tctaaattgt tccccaagct     6360

gcccggcctc cccttcatct cttgtcaaaa ggggtacaag ggtgtgtggg ccggcactgg     6420

catcatgacc acgcgctgcc cttgcggcgc caacatctct ggcaatgtcc gcctgggctc     6480

tatgaggatc acagggccta aaacctgcat gaacacctgg caggggacct ttcctatcaa     6540

ttgctacacg gagggccagt gcgcgccgaa accccccacg aactacaaga ccgccatctg     6600

gagggtggcg gcctcggagt acgcggaggt gacgcagcat gggtcgtact cctatgtaac     6660

aggactgacc actgacaatc tgaaaattcc ttgccaacta ccttctccag agtttttctc     6720

ctgggtggac ggtgtgcaga tccataggtt tgcacccaca ccaaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc ctatgctgtc gggtcccagc ttccctgtga     6840

acctgagccc gacgcagacg tattgaggtc catgctaaca gatccgcccc acatcacggc     6900

ggagactgcg gcgcggcgct tggcacgggg atcacctcca tctgaggcga gctcctcagt     6960

gagccagcta tcagcaccgt cgctgcgggc cacctgcacc acccacagca acacctatga     7020

cgtggacatg gtcgatgcca acctgctcat ggagggcggt gtggctcaga cagagcctga     7080

gtccagggtg cccgttctgg actttctcga gccaatggcc gaggaagaga gcgaccttga     7140

gccctcaata ccatcggagt gcatgctccc caggagcggg tttccacggg ccttaccggc     7200

ttgggcacgg cctgactaca acccgccgct cgtggaatcg tggaggaggc cagattacca     7260

accgcccacc gttgctggtt gtgctctccc cccccccaag aaggccccga cgcctccccc     7320

aaggagacgc cggacagtgg gtctgagcga gagcaccata tcagaagccc tccagcaact     7380

ggccatcaag acctttggcc agcccccctc gagcggtgat gcaggctcgt ccacgggggc     7440

gggcgccgcc gaatccggcg gtccgacgtc ccctggtgag ccggccccct cagagacagg     7500

ttccgcctcc tctatgcccc ccctcgaggg ggagcctgga gatccggacc tggagtctga     7560

tcaggtagag cttcaacctc ccccccaggg ggggggggta gctcccggtt cgggctcggg     7620

gtcttggtct acttgctccg aggaggacga taccaccgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccctgtag ccccgaagag gaaaagttgc caatcaaccc     7740

tttgagtaac tcgctgttgc gataccataa caaggtgtac tgtacaacat caaagagcgc     7800

ctcacagagg gctaaaaagg taacttttga caggacgcaa gtgctcgacg cccattatga     7860

ctcagtctta aaggacatca agctagcggc ttccaaggtc agcgcaaggc tcctcacctt     7920

ggaggaggcg tgccagttga ctccacccca ttctgcaaga tccaagtatg gattcggggc     7980

caaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggaa gacccacaaa caccaattcc cacaaccatc atggccaaaa atgaggtgtt     8100

ctgcgtggac cccgccaagg ggggtaagaa accagctcgc ctcatcgttt accctgacct     8160

cggcgtccgg gtctgcgaga aaatggccct ctatgacatt acacaaaagc ttcctcaggc     8220

ggtaatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg ccatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  8
<211>  3033
<212>  PRT
<213>  Hepatitis C virus

<400>  8

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Asn Leu Ile His Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly 
        755                 760                 765             


Ile Trp Trp Leu Leu Leu Val Phe Cys Ala Ser Trp His Leu Arg Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Val Thr Tyr Gly Ile Cys Gly Met Trp Pro Phe 
785                 790                 795                 800 


Phe Leu Met Leu Leu Ser Leu Pro Pro Arg Ala Tyr Ala Leu Asp Arg 
                805                 810                 815     


Glu Val Ser Ala Ala Leu Gly Thr Gly Met Leu Ala Ile Ile Leu Leu 
            820                 825                 830         


Val Thr Leu Gly Pro His Tyr Lys Arg Leu Leu Ala Leu Ile Leu Trp 
        835                 840                 845             


Trp Val Thr Tyr Phe Leu Thr Arg Cys Glu Ala Ala Leu Gln Thr Trp 
    850                 855                 860                 


Val Pro Pro Leu Asn Pro Arg Gly Gly Arg Asp Gly Phe Ile Leu Cys 
865                 870                 875                 880 


Val Pro Leu Cys Tyr Pro Gly Leu Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Val Met Met Cys Pro Leu Tyr Leu Leu Gln Leu Cys Leu Val Arg 
            900                 905                 910         


Thr Pro Tyr Phe Val Arg Ala Gln Ala Leu Ile Arg Val Cys Ser Leu 
        915                 920                 925             


Phe Lys Thr Leu Ala Gly Gly Arg Tyr Val Gln Ala Ala Leu Leu Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asn His Leu Ala Pro Leu 
945                 950                 955                 960 


Glu Thr Trp Ala Ala Gly Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Val Ile Phe Ser Pro Met Glu Lys Lys Ile Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Thr Ala Cys Gly Asp Ile  Leu Cys Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Asp Tyr Arg 
    1010                 1015                 1020             


Ser Met  Gly Trp Gln Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Ser Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Leu Pro Gly Leu  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Thr Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Ala  Pro Lys Pro Pro Thr  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Ile Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Tyr Ala Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Ala Asp Val Leu  Arg Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Pro His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Val Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Ser 
    2210                 2215                 2220             


Asn Thr  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Leu Met Glu 
    2225                 2230                 2235             


Gly Gly  Val Ala Gln Thr Glu  Pro Glu Ser Arg Val  Pro Val Leu 
    2240                 2245                 2250             


Asp Phe  Leu Glu Pro Met Ala  Glu Glu Glu Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Cys Met  Leu Pro Arg Ser Gly  Phe Pro Arg 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Arg Arg Pro Asp  Tyr Gln Pro Pro Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Lys  Lys Ala Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Ser Thr Ile  Ser Glu Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Thr Phe Gly Gln Pro  Pro Ser Ser 
    2345                 2350                 2355             


Gly Asp  Ala Gly Ser Ser Thr  Gly Ala Gly Ala Ala  Glu Ser Gly 
    2360                 2365                 2370             


Gly Pro  Thr Ser Pro Gly Glu  Pro Ala Pro Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ala Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Ser Asp Gln Val Glu  Leu Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Gly Val  Ala Pro Gly Ser Gly  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Thr Thr Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Ser Lys  Ser Ala Ser Gln Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Thr Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Leu Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Pro Gln Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Ala Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  9
<211>  9678
<212>  DNA
<213>  Hepatitis C virus

<400>  9
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacga atcctaaacc      360

tcaaagatta accaaaagaa acaccgtccg tcgcccacag aacgttaagt tcccgggtgg      420

cgggcagatc gttggcggag tctacttgtt gccgcgcagg ggccctagat tgggtgtgcg      480

cggcactagg aagagttcgg agcgatcgca gcccagggga agacgccaac gtatccccaa      540

agctgcctct tcacagggta aagcctgggg caagcccggg tacccttggc ccctgtatgg      600

taacgagggc tgtggctggg cagggtggct cctgtccccc cgcggctctc gacctacttg      660

gggccccact gacccccggc accgctcgcg aaacctcggt aaggtgatcg acaccatgac      720

ctgcgggttt gccgacctca tggggtacat ccctgtccta ggcgcccccc tagggggcgt      780

tgccagggct ctggcacatg gtgttagagt tctggaggac ggggtcaact atgcaacagg      840

gaacttgcct ggttgctcct tttctatctt cttactagcc ctcctgtcat gtctaacagt      900

cccggcatcg gcttatgaag tccgcaactc cagtggggtc tatcatctca ccaatgactg      960

ccccaacgct agtatagtct atgaaacaga caacgccatc ctacacgagc ctgggtgcgt     1020

gccttgcgtt cgcgagggta atactagcag gtgttgggaa ccagtggccc ccactttggc     1080

ggtccgctat cgcggagcgc ttactgacga tttgcggacg catattgacc tagtggtggc     1140

gtcagctacc ctgtgctccg ccttgtacgt gggggacatt tgtggagcca tcttcattgc     1200

cagccaagct gttctctgga agcccggggg gggtcggata gtgcaagatt gcaattgttc     1260

gatctacccg ggccacgtca ccggccacag gatggcgtgg gacatgatgc agaactgggc     1320

gccggccttg tcaatggttg ccgcttacgc tgtgagagtg cccggtgtca tcattaccac     1380

tgtagcgggc ggccactggg gtgtgttatt tggcctcgct tactttggta tggcgggaaa     1440

ctgggcaaag gtaatactca tcatgctact catgtccggc gtcgacgcgg aaaccatggc     1500

cgtcggggct agggccgctc acaccactgg cgcccttgtc agcctgctca atccagggcc     1560

cagtcagcgc ctgcagctga tcaacaccaa tgggtcatgg cacatcaacc ggaccgcttt     1620

gaactgcaat gactctttgc agacagggtt catagcggcc ctcttctaca cacataggtt     1680

caattctagt ggctgtcccg agaggatggc ttcttgtaaa cctctcagtg actttgacca     1740

ggggtggggc ccgctgtggt acaattcaac agaaagacct tcggaccagc gaccctattg     1800

ctggcactac gcgccatcgc cgtgtggtat tgtgccggct aaggatgttt gcggtccggt     1860

ctactgcttt acaccaagcc cggttgtggt gggcaccacg gatcgccggg gggtgcccac     1920

gtatacttgg ggtgaaaatg agtctgatgt cttcctgctc aacagcacaa ggccgccgca     1980

aggcagttgg tttgggtgct catggatgaa cacaacgggg ttcacgaaga cctgcggagg     2040

tcctccgtgc aagatacgtc cccagggtgc ccagagtaac acctctctca cttgtcccac     2100

agactgcttc aggaaacatc cgcgtgccac atactccgct tgcggatctg gtccgtggtt     2160

gacacctaga tgcatggtcc attaccccta tagactgtgg cactacccgt gtacagtcaa     2220

cttcaccata cacaaagtca ggttatacat agggggtgta gaacataggc tcgatgcagc     2280

gtgcaattgg acgcggggtg agcgatgcga cctggaggac cgagacaggg tggacatgtc     2340

ccccctgctc cattccacta cggagctcgc aatacttccg tgttcctttg tgccgcttcc     2400

ggccttatct acgggactga tccacctgca ccaaaacatc gttgacgccc agtaccttta     2460

tggtctttct cccgctataa taagctgggc catcagatgg gagtgggtag tcctcgtttt     2520

cctactcctg gcggacgcgc ggatctgcgc ctgcctttgg atgatgatgc ttatggccca     2580

ggctgaagcc gctctggaga acttgatcca cctcaacgcg gccagccttg cgggaaccca     2640

tggtatctgg tggctccttt tagtcttttg tgcctcttgg catctacgag gcagggttgt     2700

ccctctggtg acgtatggga tatgcgggat gtggcccttc ttcctcatgt tgctgagcct     2760

ccccccacga gcgtatgctc tggacaggga agtgagcgca gcgttgggaa cgggcatgct     2820

cgccatcatc ctattagtta ccttgggacc gcactacaag agacttctag cccttattct     2880

ctggtgggtc acatatttcc ttacaaggtg tgaagcagca ctccaaacgt gggtccctcc     2940

tctcaaccct cgggggggca gggacggttt catcctgtgt gtgctgctgt gctatccagg     3000

ccttgtcttt gacatcacaa aatggttgct ggtcatgatg tgccctctct acctcctcca     3060

gttgtgtttg gtgaggactc catactttgt gagggcccag gccctcatca gagtgtgttc     3120

tctcttcaaa acgctagctg ggggacggta cgtgcaggcc gcgctgctca ctattggccg     3180

ctggaccggc acttatattt ataaccatct cgcccccctg gaaacatggg ccgccggcgg     3240

cctacgggat ttggccgttg cagtcgagcc cgtgatattc tcccccatgg agaagaagat     3300

catagtttgg ggggcggaga ccactgcttg tggcgacatt ctttgtggcc tgcctgtctc     3360

agctcggctc ggcagggaag tcctgctagg gcccgcggat gactacaggt ccatgggatg     3420

gcaactcctg gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgctc cggatcctgg ctccgcgacg tgtgggactg     6300

ggtttgcacc atcttgacag acttcaaaaa ttggctgacc tctaaattgt tccccaagct     6360

gcccggcctc cccttcatct cttgtcaaaa ggggtacaag ggtgtgtggg ccggcactgg     6420

catcatgacc acgcgctgcc cttgcggcgc caacatctct ggcaatgtcc gcctgggctc     6480

tatgaggatc acagggccta aaacctgcat gaacacctgg caggggacct ttcctatcaa     6540

ttgctacacg gagggccagt gcgcgccgaa accccccacg aactacaaga ccgccatctg     6600

gagggtggcg gcctcggagt acgcggaggt gacgcagcat gggtcgtact cctatgtaac     6660

aggactgacc actgacaatc tgaaaattcc ttgccaacta ccttctccag agtttttctc     6720

ctgggtggac ggtgtgcaga tccataggtt tgcacccaca ccaaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc ctatgctgtc gggtcccagc ttccctgtga     6840

acctgagccc gacgcagacg tattgaggtc catgctaaca gatccgcccc acatcacggc     6900

ggagactgcg gcgcggcgct tggcacgggg atcacctcca tctgaggcga gctcctcagt     6960

gagccagcta tcagcaccgt cgctgcgggc cacctgcacc acccacagca acacctatga     7020

cgtggacatg gtcgatgcca acctgctcat ggagggcggt gtggctcaga cagagcctga     7080

gtccagggtg cccgttctgg actttctcga gccaatggcc gaggaagaga gcgaccttga     7140

gccctcaata ccatcggagt gcatgctccc caggagcggg tttccacggg ccttaccggc     7200

ttgggcacgg cctgactaca acccgccgct cgtggaatcg tggaggaggc cagattacca     7260

accgcccacc gttgctggtt gtgctctccc cccccccaag aaggccccga cgcctccccc     7320

aaggagacgc cggacagtgg gtctgagcga gagcaccata tcagaagccc tccagcaact     7380

ggccatcaag acctttggcc agcccccctc gagcggtgat gcaggctcgt ccacgggggc     7440

gggcgccgcc gaatccggcg gtccgacgtc ccctggtgag ccggccccct cagagacagg     7500

ttccgcctcc tctatgcccc ccctcgaggg ggagcctgga gatccggacc tggagtctga     7560

tcaggtagag cttcaacctc ccccccaggg ggggggggta gctcccggtt cgggctcggg     7620

gtcttggtct acttgctccg aggaggacga taccaccgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccctgtag ccccgaagag gaaaagttgc caatcaaccc     7740

tttgagtaac tcgctgttgc gataccataa caaggtgtac tgtacaacat caaagagcgc     7800

ctcacagagg gctaaaaagg taacttttga caggacgcaa gtgctcgacg cccattatga     7860

ctcagtctta aaggacatca agctagcggc ttccaaggtc agcgcaaggc tcctcacctt     7920

ggaggaggcg tgccagttga ctccacccca ttctgcaaga tccaagtatg gattcggggc     7980

caaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggaa gacccacaaa caccaattcc cacaaccatc atggccaaaa atgaggtgtt     8100

ctgcgtggac cccgccaagg ggggtaagaa accagctcgc ctcatcgttt accctgacct     8160

cggcgtccgg gtctgcgaga aaatggccct ctatgacatt acacaaaagc ttcctcaggc     8220

ggtaatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg tcatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  10
<211>  3033
<212>  PRT
<213>  Hepatitis C virus

<400>  10

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Asn Leu Ile His Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly 
        755                 760                 765             


Ile Trp Trp Leu Leu Leu Val Phe Cys Ala Ser Trp His Leu Arg Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Val Thr Tyr Gly Ile Cys Gly Met Trp Pro Phe 
785                 790                 795                 800 


Phe Leu Met Leu Leu Ser Leu Pro Pro Arg Ala Tyr Ala Leu Asp Arg 
                805                 810                 815     


Glu Val Ser Ala Ala Leu Gly Thr Gly Met Leu Ala Ile Ile Leu Leu 
            820                 825                 830         


Val Thr Leu Gly Pro His Tyr Lys Arg Leu Leu Ala Leu Ile Leu Trp 
        835                 840                 845             


Trp Val Thr Tyr Phe Leu Thr Arg Cys Glu Ala Ala Leu Gln Thr Trp 
    850                 855                 860                 


Val Pro Pro Leu Asn Pro Arg Gly Gly Arg Asp Gly Phe Ile Leu Cys 
865                 870                 875                 880 


Val Leu Leu Cys Tyr Pro Gly Leu Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Val Met Met Cys Pro Leu Tyr Leu Leu Gln Leu Cys Leu Val Arg 
            900                 905                 910         


Thr Pro Tyr Phe Val Arg Ala Gln Ala Leu Ile Arg Val Cys Ser Leu 
        915                 920                 925             


Phe Lys Thr Leu Ala Gly Gly Arg Tyr Val Gln Ala Ala Leu Leu Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asn His Leu Ala Pro Leu 
945                 950                 955                 960 


Glu Thr Trp Ala Ala Gly Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Val Ile Phe Ser Pro Met Glu Lys Lys Ile Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Thr Ala Cys Gly Asp Ile  Leu Cys Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Asp Tyr Arg 
    1010                 1015                 1020             


Ser Met  Gly Trp Gln Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Ser Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Leu Pro Gly Leu  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Thr Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Ala  Pro Lys Pro Pro Thr  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Ile Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Tyr Ala Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Ala Asp Val Leu  Arg Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Pro His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Val Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Ser 
    2210                 2215                 2220             


Asn Thr  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Leu Met Glu 
    2225                 2230                 2235             


Gly Gly  Val Ala Gln Thr Glu  Pro Glu Ser Arg Val  Pro Val Leu 
    2240                 2245                 2250             


Asp Phe  Leu Glu Pro Met Ala  Glu Glu Glu Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Cys Met  Leu Pro Arg Ser Gly  Phe Pro Arg 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Arg Arg Pro Asp  Tyr Gln Pro Pro Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Lys  Lys Ala Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Ser Thr Ile  Ser Glu Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Thr Phe Gly Gln Pro  Pro Ser Ser 
    2345                 2350                 2355             


Gly Asp  Ala Gly Ser Ser Thr  Gly Ala Gly Ala Ala  Glu Ser Gly 
    2360                 2365                 2370             


Gly Pro  Thr Ser Pro Gly Glu  Pro Ala Pro Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ala Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Ser Asp Gln Val Glu  Leu Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Gly Val  Ala Pro Gly Ser Gly  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Thr Thr Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Ser Lys  Ser Ala Ser Gln Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Thr Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Leu Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Pro Gln Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Ala Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  11
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  11
gtagcgttgg gttgcgaaag gccttgtggt actgcctgat                             40


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  12
gacggccatg gtttccgcgt cgac                                              24


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  13
ccacaggatg gcgtgggaca tgatg                                             25


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  14
cccgcgtcca attgcacgct g                                                 21


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  15
cggggttcac gaagacctgc ggag                                              24


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  16
ccccccgagg gttgagagga gg                                                22


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  17
cctcaacgcg gccagccttg c                                                 21


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  18
cccgcgtctc cgagccggga tg                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OligoDNA primer

<400>  19
gtcctgctag ggcccgcgga tg                                                22


<210>  20
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligoDNA primer

<400>  20
cgcccgaggc ctacctcttc tatatc                                            26


<210>  21
<211>  3013
<212>  PRT
<213>  Hepatitis C virus

<400>  21

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Asn Leu Ile His Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly 
        755                 760                 765             


Ile Trp Trp Leu Leu Leu Val Phe Cys Ala Ser Trp His Leu Arg Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Val Thr Tyr Gly Ile Cys Gly Met Trp Pro Phe 
785                 790                 795                 800 


Phe Leu Met Leu Leu Ser Leu Pro Pro Arg Ala Tyr Ala Leu Asp Arg 
                805                 810                 815     


Glu Val Ser Ala Ala Leu Gly Thr Gly Met Leu Ala Ile Ile Leu Leu 
            820                 825                 830         


Val Thr Leu Gly Pro His Tyr Lys Arg Leu Leu Ala Leu Ile Leu Trp 
        835                 840                 845             


Trp Val Thr Tyr Phe Leu Thr Arg Cys Glu Ala Ala Leu Gln Thr Trp 
    850                 855                 860                 


Val Pro Pro Leu Asn Pro Arg Gly Gly Arg Asp Gly Phe Ile Leu Cys 
865                 870                 875                 880 


Val Leu Leu Cys Tyr Pro Gly Leu Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Val Met Met Cys Pro Leu Tyr Leu Leu Gln Leu Cys Leu Val Arg 
            900                 905                 910         


Thr Pro Tyr Phe Val Arg Ala Gln Ala Leu Ile Arg Val Cys Ser Leu 
        915                 920                 925             


Phe Lys Thr Leu Ala Gly Gly Arg Tyr Val Gln Ala Ala Leu Leu Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asn His Leu Ala Pro Leu 
945                 950                 955                 960 


Glu Thr Trp Ala Ala Gly Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Val Ile Phe Ser Pro Met Glu Lys Lys Ile Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Thr Ala Cys Gly Asp Ile  Leu Cys Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Asp Tyr Arg 
    1010                 1015                 1020             


Ser Met  Gly Trp Gln Leu Leu  Ala Pro Ile Ser Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Ile Ser  Thr Leu Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Thr Ala  Gly Glu Val Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Ser Thr  Gln Thr Phe Leu Gly  Thr Asn Val Gly Gly  Val Met Trp 
    1070                 1075                 1080             


Gly Pro  Tyr His Gly Ala Gly  Thr Arg Thr Val Ala  Gly Arg Gly 
    1085                 1090                 1095             


Gly Pro  Val Leu Gln Met Tyr  Thr Ser Val Ser Asp  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ala Pro Pro Gly  Ser Lys Ser Leu Glu  Pro Cys Ser 
    1115                 1120                 1125             


Cys Gly  Ser Ala Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Leu Pro  Leu Arg Arg Lys Gly  Asp Gly Thr Ala Ser  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Val Ser Ser Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Gln Ser His Cys  Val Gly Ile Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Thr  Arg Gly Val Ala Lys  Ala Val Gln Phe Val  Pro Ile Glu 
    1190                 1195                 1200             


Lys Met  Gln Val Ala Gln Arg  Ser Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Ser  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  Tyr Gly Ile 
    1265                 1270                 1275             


Asp Pro  Ser Val Arg Thr Gly  Ala Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ser  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Ile  Asp Ala Thr Thr Val  Val Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ser Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Val Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Asn Asp Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Gln His Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Gly Lys  Leu Thr Ser 
    1400                 1405                 1410             


Leu Gly  Leu Thr Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Ser Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Phe Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Thr  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Glu Thr Thr Thr  Val Pro Gln Asp Ser  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Thr 
    1505                 1510                 1515             


Ser Val  Leu Cys Glu Cys Tyr  Asp Leu Gly Cys Ser  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Thr Arg Leu Arg Ala  Tyr Leu Asn 
    1535                 1540                 1545             


Cys Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Gly Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Glu Gly Gln  Asn Tyr Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Gln Trp Lys Cys Leu  Gln Arg Leu Lys Pro  Leu Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Phe Thr His Pro Ile  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Ala Ala  Asp Leu Glu Val Thr  Thr Ser Thr Trp Val  Ile Val Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Met Ser  Thr Gly Ser 
    1670                 1675                 1680             


Val Val  Val Val Gly Arg Val  Val Leu Gly Ser Asn  Val Val Thr 
    1685                 1690                 1695             


Ala Pro  Asp Arg Glu Val Leu  Tyr Gln His Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ser Lys Ala Pro Glu  Leu Leu Lys His Ala  Gln Thr Ile 
    1715                 1720                 1725             


Gly Gly  Met Phe Lys Asp Lys  Ala Leu Ala Val Leu  Asp Thr Leu 
    1730                 1735                 1740             


Lys Pro  Ala Ala Gln Ala Ala  Val Pro Ile Val Glu  Thr Asn Phe 
    1745                 1750                 1755             


Gln Lys  Val Glu Lys Leu Trp  Asn Gln His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Thr  Val Ala Ser Leu Met  Ala Phe Thr Ala Ser  Val Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ala Thr Ser Thr Thr  Leu Leu Val Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Phe  Ala Ser Gln Leu Ala  Pro Pro Ser Ala Ala  Thr Thr Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Ala Gly  Ala Ala Val Gly Ser  Val Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ala Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Val Pro 
    1865                 1870                 1875             


Ser Thr  Glu Asp Leu Ala Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Val Cys Ala Ala Ile  Ile Lys Arg 
    1895                 1900                 1905             


His Thr  Gly Thr Ser Glu Gly  Val Thr Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ser Pro  Thr His Tyr 
    1925                 1930                 1935             


Ile Gln  Asp Asp Asp Ala Ser  Lys Arg Val Met Gly  Ile Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Ile Lys Arg Val Leu  Ala Trp Ala 
    1955                 1960                 1965             


Gln Thr  Asp Tyr Ser Ala Pro  Cys Ala Gly Ser Trp  Leu Arg Glu 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Met  Val Leu Ser Asp Phe  Ala Ser Trp 
    1985                 1990                 1995             


Leu Lys  Ala Lys Val Leu Pro  Ser Leu Pro Gly Ile  Pro Phe Leu 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Glu Trp Arg Asn  Asp Gly Ile 
    2015                 2020                 2025             


Met Asn  Thr Lys Cys Pro Cys  Gly Ala Leu Ile Ala  Gly His Val 
    2030                 2035                 2040             


Lys Asn  Gly Ser Met Arg Ile  Val Gly Pro Lys Thr  Cys Arg Asn 
    2045                 2050                 2055             


Thr Trp  Trp Gly Thr Phe Pro  Ile Asn Ser His Thr  Thr Gly Pro 
    2060                 2065                 2070             


Ser Ser  Pro Val Pro Ser His  Cys Tyr Gln Arg Ala  Leu Trp Arg 
    2075                 2080                 2085             


Val Ser  Ala Thr Glu Tyr Val  Glu Ile Leu Arg His  Asn Asp Gln 
    2090                 2095                 2100             


His Tyr  Val Val Gly Val Thr  Ala Glu Asp Leu Lys  Cys Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ser Pro Glu Phe  Phe Ser Phe Val Asp  Gly Val Arg 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Glu  Pro Lys Pro Met Ile  Arg Glu Glu 
    2135                 2140                 2145             


Ala Ala  Phe Val Val Gly Leu  His Ser Tyr Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Val Gln Thr Val  Ser Gln Leu 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Arg  Arg Gly Ser Pro Pro  Ser Asn Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr His Thr  Thr Leu Pro 
    2210                 2215                 2220             


Gln His  Pro Asp Ala Glu Leu  Ile Glu Ala Asn Leu  Met Trp Glu 
    2225                 2230                 2235             


His Lys  Val Gly Ala Ile Arg  Arg Met Glu Thr Asp  Thr Lys Val 
    2240                 2245                 2250             


Ile Ile  Leu Asp Ser Phe Asp  Ser Ala Ser Ser Val  Glu Asp Asp 
    2255                 2260                 2265             


Met Glu  Pro Ser Thr Ala Ala  Glu Cys Leu Arg Thr  Arg Lys Val 
    2270                 2275                 2280             


Phe Pro  Pro Ala Met Pro Ile  Trp Ala Arg Pro Asp  Tyr Asn Pro 
    2285                 2290                 2295             


Pro Val  Val Glu Asn Trp Lys  Asp Pro Glu Tyr Ala  Pro Pro Gln 
    2300                 2305                 2310             


Val Ser  Gly Cys Ala Leu Pro  Pro Ala Gln Thr Pro  Pro Val Pro 
    2315                 2320                 2325             


Pro Pro  Arg Arg Lys Arg Ala  Val Ile Gln Leu Thr  Glu Ser Ala 
    2330                 2335                 2340             


Val Ser  Thr Ala Leu Ala Glu  Leu Ala Glu Arg Ser  Phe Pro Lys 
    2345                 2350                 2355             


Glu Glu  Ala Pro Pro Ser Asp  Ser Ala Ile Ser Leu  Asp Ser Pro 
    2360                 2365                 2370             


Ala Ala  Asn Asp Pro Pro Ser  Asp Cys Asp Gln Gly  Ser Glu Ile 
    2375                 2380                 2385             


Ser Phe  Ser Ser Met Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro 
    2390                 2395                 2400             


Asp Leu  Ser Asp Gly Ser Trp  Ser Thr Val Ser Thr  Arg Ser Asp 
    2405                 2410                 2415             


Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp Thr Gly  Ala Leu Val 
    2420                 2425                 2430             


Thr Pro  Ser Gly Pro Glu Glu  Glu Arg Leu Pro Ile  Asn Ala Leu 
    2435                 2440                 2445             


Ser Asn  Thr Met Leu Arg His  Tyr Asn Met Val Tyr  Ser Thr Thr 
    2450                 2455                 2460             


Ser Arg  Ser Ala Ser Gln Arg  Ala Lys Lys Val Thr  Phe Asp Arg 
    2465                 2470                 2475             


Leu Gln  Val Leu Asp Asp His  Tyr Lys Arg Ala Leu  Ala Asp Val 
    2480                 2485                 2490             


Lys Ala  Asp Ala Ser Thr Val  Lys Ala Gln Leu Leu  Ser Val Glu 
    2495                 2500                 2505             


Glu Ala  Ala Ala Leu Thr Pro  Ala His Ser Ala Arg  Ser Lys Phe 
    2510                 2515                 2520             


Gly Tyr  Gly Ala Lys Glu Val  Arg Ser Leu Ala Pro  Lys Ala Met 
    2525                 2530                 2535             


Ser His  Ile Lys Glu Val Trp  Lys Asp Leu Leu Gln  Asp Met Thr 
    2540                 2545                 2550             


Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys Asn Glu  Val Phe Cys 
    2555                 2560                 2565             


Val Asn  Pro Ala Lys Gly Gly  Lys Lys Pro Ala Arg  Leu Ile Val 
    2570                 2575                 2580             


Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu Lys Arg  Ala Leu Tyr 
    2585                 2590                 2595             


Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile Met Gly  Gln Ala Tyr 
    2600                 2605                 2610             


Gly Phe  Gln Tyr Ser Pro Ser  Gln Arg Val Glu Tyr  Leu Val Lys 
    2615                 2620                 2625             


Thr Trp  Lys Ser Lys Arg Thr  Pro Met Gly Phe Ser  Tyr Asp Thr 
    2630                 2635                 2640             


Arg Cys  Phe Asp Ser Thr Val  Thr Glu Gln Asp Ile  Arg Thr Glu 
    2645                 2650                 2655             


Ser Glu  Ile Tyr Gln Cys Cys  Asn Leu Asp Pro Glu  Ala Arg Thr 
    2660                 2665                 2670             


Ile Ile  Asn Ala Leu Thr Glu  Arg Leu Tyr Val Gly  Gly Pro Met 
    2675                 2680                 2685             


Phe Asn  Ser Lys Gly Gln Arg  Val Gly Tyr Arg Arg  Cys Arg Ala 
    2690                 2695                 2700             


Ser Gly  Val Phe Pro Thr Ser  Met Gly Asn Thr Met  Thr Cys Tyr 
    2705                 2710                 2715             


Ile Lys  Ala Lys Ala Ala Ala  Ala Ala Ala Gly Leu  Glu Ser Thr 
    2720                 2725                 2730             


Asp Phe  Leu Val Cys Gly Asp  Asp Leu Val Val Ile  Cys Glu Ser 
    2735                 2740                 2745             


Lys Gly  Val Glu Arg Asp Arg  Ala Asp Leu Gln Ala  Phe Ala Ala 
    2750                 2755                 2760             


Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly Asp Met  Pro Gln Pro 
    2765                 2770                 2775             


Ala Tyr  Asp Leu Glu His Ile  Asp Ser Cys Ser Ser  Asn Val Ser 
    2780                 2785                 2790             


Val Ala  Arg Asp Asn Ser Gly  Lys Arg Val Tyr Tyr  Leu Thr Arg 
    2795                 2800                 2805             


Asp Pro  Thr Asn Pro Leu Ser  Arg Ala Ala Trp Glu  Thr Ala Arg 
    2810                 2815                 2820             


His Ser  Pro Val Asn Ser Trp  Val Gly Asn Ile Ile  Met Phe Ala 
    2825                 2830                 2835             


Pro Thr  Ile Trp Val Arg Met  Val Leu Met Thr His  Phe Phe Ala 
    2840                 2845                 2850             


Leu Leu  Leu Asn Glu Glu Arg  Leu Asn Asp Pro Val  Ser Phe Glu 
    2855                 2860                 2865             


Met Tyr  Gly Ala Thr Tyr Thr  Val Cys Pro Thr Asp  Leu Pro Asp 
    2870                 2875                 2880             


Ile Ile  Gln Arg Leu His Gly  Leu Arg Ala Phe Glu  Leu His Thr 
    2885                 2890                 2895             


Tyr Ser  Pro Ala Glu Leu Thr  Arg Val Ala Ala Thr  Leu Arg Lys 
    2900                 2905                 2910             


Leu Gly  Val Pro Pro Leu Arg  Thr Trp Arg Gln Arg  Ala Arg Lys 
    2915                 2920                 2925             


Val Arg  Ala Gly Leu Ile Gly  Gln Gly Gly Arg Ala  Arg Ile Cys 
    2930                 2935                 2940             


Gly Leu  Tyr Leu Phe Asn Trp  Ala Val Arg Thr Lys  Ile Lys Leu 
    2945                 2950                 2955             


Thr Pro  Leu Ala Gly Ala Gly  Arg Leu Asp Leu Ser  Ser Trp Phe 
    2960                 2965                 2970             


Ser Val  Cys Ala Gly Glu Ala  Asp Val Asp His Ser  Thr Pro Arg 
    2975                 2980                 2985             


Ala His  Pro Arg Pro Leu Leu  Leu Cys Leu Leu Leu  Leu Ala Val 
    2990                 2995                 3000             


Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3005                 3010             


<210>  22
<211>  3033
<212>  PRT
<213>  Hepatitis C virus

<400>  22

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Glu Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Arg Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Ser Gly Ala Ala Arg Ala Val Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Phe Pro Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Ala 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Ser Ser Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Glu Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Val Gly Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Pro Val Ser Pro Asn Met Ala Val Arg Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Phe Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Val Phe Ile Val Ser Pro Gln Tyr His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Val Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr Thr Thr Val Gly Gly Ala Val Ala Arg Ser Thr Asn Val Ile Ala 
385                 390                 395                 400 


Gly Val Phe Ser His Gly Pro Gln Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr Asn Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Gly Arg Leu Ser Ala Cys Arg Asn Ile Glu Ala 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Val Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Met Tyr Gly Leu Ser Pro Ala Ile Thr Lys Tyr Val Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Val Leu His Ala Ala Ser Ala Ala Asn Cys His Gly 
        755                 760                 765             


Leu Leu Tyr Phe Ala Ile Phe Phe Val Ala Ala Trp His Ile Arg Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Thr Thr Tyr Cys Leu Thr Gly Leu Trp Pro Phe 
785                 790                 795                 800 


Cys Leu Leu Leu Met Ala Leu Pro Arg Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Pro Val His Gly Gln Ile Gly Val Gly Leu Leu Ile Leu Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Gly Gln Cys Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Ile Gln Glu Trp 
    850                 855                 860                 


Val Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ala Trp Ala 
865                 870                 875                 880 


Val Thr Ile Phe Cys Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Leu Leu Gly Pro Ala Tyr Leu Leu Arg Ala Ala Leu Thr His 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Ile Arg Val Cys Ala Leu 
        915                 920                 925             


Val Lys Gln Leu Ala Gly Gly Arg Tyr Val Gln Val Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Gln Glu Ile Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Ser Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Leu Pro Gly Leu  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Thr Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Ala  Pro Lys Pro Pro Thr  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Ile Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Tyr Ala Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Ala Asp Val Leu  Arg Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Pro His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Val Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Ser 
    2210                 2215                 2220             


Asn Thr  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Leu Met Glu 
    2225                 2230                 2235             


Gly Gly  Val Ala Gln Thr Glu  Pro Glu Ser Arg Val  Pro Val Leu 
    2240                 2245                 2250             


Asp Phe  Leu Glu Pro Met Ala  Glu Glu Glu Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Cys Met  Leu Pro Arg Ser Gly  Phe Pro Arg 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Arg Arg Pro Asp  Tyr Gln Pro Pro Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Lys  Lys Ala Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Ser Thr Ile  Ser Glu Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Thr Phe Gly Gln Pro  Pro Ser Ser 
    2345                 2350                 2355             


Gly Asp  Ala Gly Ser Ser Thr  Gly Ala Gly Ala Ala  Glu Ser Gly 
    2360                 2365                 2370             


Gly Pro  Thr Ser Pro Gly Glu  Pro Ala Pro Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ala Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Ser Asp Gln Val Glu  Leu Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Gly Val  Ala Pro Gly Ser Gly  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Thr Thr Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Ser Lys  Ser Ala Ser Gln Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Thr Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Leu Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Pro Gln Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Ala Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  23
<211>  9357
<212>  DNA
<213>  Hepatitis C virus

<400>  23
gaatcactcc cctgcgagga accactgtcc tcacgcagaa agcgtctagc catgacgtta       60

gtatgagtgt cgtacagcct ccaggacccc ccctcccggg agagccatag tggtctgcgg      120

aaccggtgag tacaccggaa ttgccgggaa gactgggtcc tttcttggat caacccactc      180

tatgcccgga gatttgggcg tgcccccgcg agactgctag ccgagtagtg ttgggtcgcg      240

aaaggccttg tggtactgcc tgatagggtg cttgcgagtg ccccgggagg tctcgtagac      300

cgtgcaccat gagcacgaat cctaaacctc aaagattaac caaaagaaac accgtccgtc      360

gcccacagaa cgttaagttc ccgggtggcg ggcagatcgt tggcggagtc tacttgttgc      420

cgcgcagggg ccctagattg ggtgtgcgcg gcactaggaa gagttcggag cgatcgcagc      480

ccaggggaag acgccaacgt atccccaaag ctgcctcttc acagggtaaa gcctggggca      540

agcccgggta cccttggccc ctgtatggta acgagggctg tggctgggca gggtggctcc      600

tgtccccccg cggctctcga cctacttggg gccccacyga cccccggcac cgctcgcgaa      660

acctcggtaa ggtgatcgac accatgacct gcgggtttgc cgacctcatg gggtacatcc      720

ctgtcctagg cgccccccta gggggcgttg ccagggctct ggcacatggt gttagagttc      780

tggaggacgg ggtcaactat gcaacaggga acttgcctgg ttgctccttt tctatcttcy      840

tactagccct cctgtcatgt ctaacagtcc cggcatcggc ttatgaagtc cgcaactcca      900

gtggrgtcta tcatctcacc aatgactgcc ccaacgctag tatagtctat gaaacagaca      960

acgccatcct acacgagcct gggtgcgtgc cttgcgttcg cgagggtaat actagcaggt     1020

gttgggaacc agtggccccc actttggcgg tccgctatcg cggagcgctt actgacgatt     1080

tgcggacgca tattgaccta gtggtggcgt cagctaccct gtgctccgcc ttgtacgtgg     1140

gggacatttg tggagccatc ttcattgcca gccaagctgt tctctggaag cccggggggg     1200

gtcggatagt gcaagattgc aattgttcga tctacccggg ccacgtcacc ggccacagga     1260

tggcgtggga catgatgcag aactgggcgc cggccttgtc aatggttgcc gcttacgctg     1320

tgagagtgcc cggtgtcatc attaccactg tagcgggcgg ccactggggt gtgttatttg     1380

gcctcgctta ctttggtatg gcgggaaact gggcaaaggt aatactcatc atgctactca     1440

tgtccggcgt cgacgcggaa accatggccg tcggggctag ggccgctcac accactggcg     1500

cccttgtcag cctgctcaat ccagggccca gtcagcgcct gcagctgatc aacaccaatg     1560

ggtcatggca catcaaccgg accgctttga actgcaatga ctctttgcag acagggttca     1620

tagcggccct cttctacaca cataggttca attctagtgg ctgtcccgag aggatggctt     1680

cttgtaaacc tctcagtgac tttgaccagg ggtggggccc gctgtggtac aattcaacag     1740

aaagaccttc ggaccagcga ccctattgct ggcactacgc gccatcgccg tgtggtattg     1800

tgccggctaa ggatgtttgc ggtccggtct actgctttac accaagcccg gttgtggtgg     1860

gcaccacgga tcgccggggg gtgcccacgt atacttgggg tgaaaatgag tctgatgtct     1920

tcytgctcaa cagcacaagg ccgccgcaag gcagttggtt tgggtgctca tggatgaaca     1980

caacggggtt cacgaagacc tgcggaggtc ctccgtgcaa gatacgtccc cagggtgccc     2040

agagtaacac ctctctcact tgtcccacag actgcttcag gaaacatccg cgtgccacat     2100

actccgcttg cggatctggt ccgtggttga cacctagatg catggtccat tacccctata     2160

gactgtggca ctacccgtgt acagtcaact tcaccataca caaagtcagg ttatacatag     2220

ggggtgtaga acataggctc gatgcagcgt gcaattggac gcggggtgag cgatgcgacc     2280

tggaggaccg agacagggtg gacatgtccc ccctgctcca ttccactacg gagctcgcaa     2340

tacttccgtg ttcctttgtg ccgcttccgg ccttatctac gggactgatc cacctgcacc     2400

aaaacatcgt tgacgcccag tacctttatg gtctttctcc cgctataata agctgggcca     2460

tcagatggga gtgggtagtc ctcgttttcc tactcctggc ggacgcgcgg atctgcgcct     2520

gcctttggat gatgatgctt atggcccagg ctgaagccgc tctggagaac ttgatccacc     2580

tcaacgcggc cagccttgcg ggaacccatg gtatctggtg gctcctttta gtcttttgtg     2640

cctcttggca tctacgaggc agggttgtcc ctctggtgac gtatgggata tgcgggatgt     2700

ggcccttctt cctcatgttg ctgagcctcc ccccacgagc gtatgctctg gacagggaag     2760

tgagcgcagc gttgggaacg ggcatgctcg ccatcatcct attagttacc ttgggaccgc     2820

actacaagag acttctagcc cttattctct ggtgggtcac atatttcctt acaaggtgtg     2880

aagcagcact ccaaacgtgg gtccctcctc tcaaccctcg ggggggcagg gacggtttca     2940

tcctgtgtgt gctgctgtgc tatccaggcc ttgtctttga catcacaaaa tggttgctgg     3000

tcatgatgtg ccctctctac ctcctccagt tgtgtttggt gaggactcca tactttgtga     3060

gggcccaggc cctcatcaga gtgtgttctc tcttcaaaac gctagctggg ggacggtacg     3120

tgcaggccgc gctgctcact attggccgct ggaccggcac ttatatttat aaccatctcg     3180

cccccctgga aacatgggcc gccggcggcc tacgggattt ggccgttgca gtcgagcccg     3240

tgatattctc ccccatggag aagaagatca tagtttgggg ggcggagacc actgcttgtg     3300

gcgacattct ttgtggcctg cctgtctcag ctcggctcgg cagggaagtc ctgctagggc     3360

ccgcggatga ctacaggtcc atgggatggc aactcctggc tccaatctca gcatacgcac     3420

agcagacccg cggtctcatc tctacccttg tcgtgagcct cactggccgt gataagaacg     3480

agactgccgg cgaggtgcag gtgttgtcca cctcaacgca gaccttcctg gggaccaatg     3540

tgggcggtgt catgtgggga ccttatcacg gagcgggcac gcggactgtg gccggccggg     3600

gtgggcctgt cctccagatg tacacgtcag tcagtgacga tctggtgggc tggcctgccc     3660

cgcctggctc caagtccctc gagccctgct cgtgcgggtc agcagacctt tacttggtga     3720

cgcgcaatgc tgacgtcctt cctcttagga ggaagggtga cggtacagcg tccctactgt     3780

ccccgcgccc tgtgtcctcc cttaaaggct cctcgggagg gcctgtcttg tgcccccaaa     3840

gtcattgcgt tggcatcttc agagctgctg tctgcacccg cggtgtagcc aaagcagttc     3900

agtttgttcc catcgagaag atgcaggtgg cccagaggtc gccatcattc agtgacaata     3960

gcacccctcc agcggtgccc agcacctatc aagtaggcta tttacatgcc cccactggca     4020

gcggcaagag cactaaggtc cctgcggcgt atgccagcca gggctacaaa gtgctcgtgc     4080

ttaatccatc agtcgcggcc acccttgggt ttggtgccta catgtccaag gcttatggaa     4140

ttgatccaag tgtgcgcacc ggcgcgcgca cggtgaccac gggggctccc ataacttact     4200

caacctatgg gaagttcctt gccgacgggg gttgttcagg tggtgcctat gatataatca     4260

tatgtgatga atgccatgcc atcgatgcta ccaccgtggt cggcataggc accgtgttgg     4320

accaggcaga gactagtggt gtccgacttg tggtgctagc tacggccacc ccccccggaa     4380

gcgttacggt gccccacccc aacatcgagg aggtcgccct tggcaacgat ggggaaattc     4440

ccttctatgg gaaagccatc cccctgcaac acatcaaggg gggaaggcat ctcattttct     4500

gtcattccaa aaagaaatgt gatgagcttg ccgggaagct cacctcattg gggctgactg     4560

ccgttgctta ctataggggg ttggatgttt cggtgatccc aacgtctggc gatgtagtcg     4620

tggtggctac tgatgccttg atgacgggct ttaccggaga cttcgactcc gtcatagact     4680

gcaacgtggc ggttacccag actgtagact tctccttgga ccccaccttc actattgaga     4740

ccaccacagt cccgcaagat tctgtctcgc gctctcagag acgtgggagg acaggtaggg     4800

gcaggcttgg catctacaga tacgtgtcca gtggcgagcg gccatccggt atgttcgaca     4860

ccagcgtgct ctgtgagtgc tatgacctgg ggtgctcgtg gtatgaacta acgcccagtg     4920

aaaccaccac gcgcctcaga gcctacctca attgccctgg tcttccagtg tgccaagacc     4980

atctggagtt ctgggagggc gtctttacgg gacttactca tattgatgca cacttcctgt     5040

cccagaccaa acaagagggc caaaattatg cgtacctgac tgcataccaa gctacagtgt     5100

gcgcccgggc gaaagccccc ccgccctcct gggacgtcca gtggaagtgt ctccaaagac     5160

taaagccact gttagtaggg cccacgccct tgctatacag gctaggcagt gttaccaatg     5220

aagtcacatt cactcatccc atcaccaaat acattgccac gtgcatggct gccgacttgg     5280

aggtcactac gagcacctgg gtgatcgtag gtggcgtcct cgccgccgtg gccgcatatt     5340

gcatgtctac tggcagtgtt gttgtggttg gccgtgtggt ccttggatcc aacgtggtga     5400

cggcccccga cagagaggtt ttataccagc actttgatga gatggaagag tgctccaaag     5460

ctcctgaatt gctgaaacac gcccaaacca tcggcggaat gttcaaggac aaggccctcg     5520

ccgtcttgga tacgctcaag ccggccgccc aggctgctgt tcccattgtg gagaccaact     5580

tccaaaaggt ggagaagctg tggaatcagc atatgtggaa cttcataagc ggcattcaat     5640

acctagctgg gctatccaca ctgccaggta atccaactgt ggcctcactg atggccttca     5700

ccgcctcagt tactagcccc cttgctacat cgaccacact actagtcaac atcctgggtg     5760

ggtggttcgc aagccagtta gcgccgccgt ctgctgccac gactttcgtg gtctcgggcc     5820

tcgcaggggc ggcagtgggt agtgttggct tgggcaaggt cttagttgat gtcctggccg     5880

gctatggcgc cggcatagct ggcgccctgg tggccttcaa aatcatgtct ggagaggtcc     5940

ctagcacaga ggatctggca aacctcttac ctgccatact ctcacctgga gctttagttg     6000

tgggagttgt ttgtgccgcg atcatcaaac ggcataccgg cactagtgag ggagtcacgc     6060

agtggatgaa ccgtctcatt gcgttcgcct cccgtggaaa tcacgtgtcg ccgacccact     6120

acatacagga tgatgatgcg tcaaaacgcg tcatggggat actcagctcc cttaccatca     6180

ccagcctcat aaaacgagta ctggcctggg cgcagactga ytattctgcg ccctgtgccg     6240

ggagctggct ccgggaggtg tgggactggg tttgcatggt cctatccgac tttgcatctt     6300

ggttgaaggc caaggtactt cccagccttc cagggatccc attcctatcc tgtcagaaag     6360

ggtataaagg tgagtggcgg aacgatggca tcatgaacac caagtgcccg tgtggggccc     6420

tgatagcagg gcacgtcaag aacggatcga tgcgcatcgt gggccccaag acctgccgaa     6480

acacctggtg gggaaccttc cctattaatt cccataccac gggaccaagt tctcctgtac     6540

cctcccaytg ttatcaaagg gccttgtgga gggtatctgc racggagtac gtcgagatcc     6600

ttcgtcacaa tgaccagcat taygtggtgg gagtgacggc ggaggacctc aagtgcccgt     6660

gtcaggttcc ttcccccgaa ttcttcagct ttgtggacgg ggtgcggata cacagattcg     6720

cccctgaacc caagcccatg atccgggaag aagccgcttt cgtggtgggt ctgcactcat     6780

atgtggtggg gtctcagctc ccttgtgaac cggagccgga cgtccaaact gtctcgcagc     6840

tcctaaccga cccctcacac atcaccgcag aaaccgcggc tagaaggctc aggagaggtt     6900

cccccccatc caacgccagt tcttctgcta gtcaactctc agctccatct ctaaaagcca     6960

cccacacaac tctgccacaa catcctgacg cagaactgat agaggccaac ctcatgtggg     7020

aacataaggt tggtgccatc agaaggatgg agacagacac caaagtcatc atacttgact     7080

cctttgattc agcttcttcc gtygaggatg acatggaacc gtccaccgcc gcggagtgtc     7140

tgcgtacgcg taaggtcttc ccaccggcca tgcccatatg ggcgaggcca gactacaatc     7200

ctcctgttgt ggagaattgg aaggaccccg agtacgcacc tccccaggtg tctgggtgcg     7260

ctctaccacc tgcgcagacc cctcctgttc caccacccag gcggaagcgg gcggttatcc     7320

aactcacaga gtccgcggtt tccacggcac tggcggaact cgctgagagg tccttcccaa     7380

aggaggaggc accccccagc gactccgcca ttagtctgga ttcaccggcg gcaaatgacc     7440

ctccatctga ttgtgaccaa ggcagtgaga tctctttctc atccatgcca cccctagagg     7500

gggagccggg tgatccagac ttgtctgatg gctcttggtc aacagtcagc accagatctg     7560

acgtgatttg ctgttccatg tcctactcat ggacgggagc cttagtgacg ccctccggtc     7620

cggaggagga aaggctccca ataaatgccc tyagtaacac catgcttcgg cattataaca     7680

tggtttacag cacaacatca cgctcagctt cacaaagagc aaaaaaagtg acttttgaca     7740

gattgcaagt cctagacgac cactacaaaa gggcgctcgc cgacgtgaaa gcggatgctt     7800

ccacggttaa ggcgcagttg ctctcagtag aggaagctgc tgccctcacc cctgcccact     7860

cagccagatc taagtttggg tacggggcaa aggaagtcag atctcttgcg cccaaggcaa     7920

tgtctcacat caaagaggtc tggaaggact tgctacagga catgaccacc ccgataccga     7980

ccaccataat ggccaagaat gaagtcttct gcgtaaatcc tgccaagggc gggaaaaagc     8040

cagctagact gattgtttac cctgacctag gtgtgagggt atgcgagaag cgggctttgt     8100

acgacatagc tcaaaagctt ccgaaggcca taatggggca ggcgtacggg ttccaatatt     8160

caccatcgca gcgggtcgar tacytagtta agacgtggaa gtccaaacgg actcccatgg     8220

gcttctcata tgacacccgc tgctttgatt ccactgtcac agaacaagac atccgcactg     8280

agagcgagat ctatcagtgc tgcaacctcg accccgaggc tcgcaccatc attaacgccc     8340

ttaccgagag gttgtacgtg gggggaccca tgttcaactc taaaggtcag agggtcggtt     8400

atcgaaggtg cagagccagc ggagttttcc ccaccagcat gggaaacact atgacgtgct     8460

acatcaaagc caaagcggct gcagcagctg cagggctaga gagcactgat ttcctggtct     8520

gcggcgatga cttggtggtc atttgcgaga gcaagggagt cgaacgggat agggcggacc     8580

tgcaagcctt tgcagcggca atgaccaggt actccgctcc acccggggac atgccccagc     8640

ccgcttatga ccttgagcac attgactctt gctcatccaa tgtctcagtc gcccgggaca     8700

actcggggaa aagagtctac tacctcacta gagaccctac caacccacta tccagggcag     8760

cttgggagac cgcccgtcac tcacctgtaa actcctgggt gggcaacata atcatgtttg     8820

cccccaccat atgggtgagg atggttctca tgactcactt tttcgctctc ctcctcaatg     8880

aggagcgatt gaacgatcca gtgagttttg agatgtatgg tgcaacctac acggtctgcc     8940

caacagactt accagacatt atacaaagac tccatgggct ccgcgcattt gaactccata     9000

cttactctcc agcagaactg acgcgggtgg cagctaccct caggaagctt ggggtgccac     9060

ccctcaggac ctggagacaa cgggctcgca aggtccgcgc ggggctgata ggccaggggg     9120

gcagggctcg catatgcggt ctctacctct tcaactgggc tgtcaggacc aagatcaaac     9180

tcactccact tgcaggcgct ggccggctcg atctttcgag ctggttcagc gtttgcgccg     9240

gcgaggcgga cgtggatcac agcacgccca gagcccatcc tcgcccatta ctcctgtgcc     9300

tactcctact tgccgtaggg gtaggcattt tcctcctacc cgctcggtaa gcgggta        9357


<210>  24
<211>  9678
<212>  DNA
<213>  Hepatitis C virus

<400>  24
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

cgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccagaa gacgttaagt tcccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cacgacaagg aaaacttcgg agcggtccca gccacgtggg agacgccagc ccatccccaa      540

agatcggcgc tccactggca aggcctgggg aaaaccaggt cgcccctggc ccctatatgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggctctc gcccctcctg      660

gggccccact gacccccggc ataggtcgcg caacgtgggt aaagtcatcg acaccctaac      720

gtgtggcttt gccgacctca tggggtacat ccccgtcgta ggcgccccgc ttagtggcgc      780

cgccagagct gtcgcgcacg gcgtgagagt cctggaggac ggggttaatt atgcaacagg      840

gaacctaccc ggtttcccct tttctatctt cttgctggcc ctgttgtcct gcatcaccgt      900

tccggtctct gctgcccagg tgaagaatac cagtagcagc tacatggtga ccaatgactg      960

ctccaatgac agcatcactt ggcagctcga ggctgcggtt ctccacgtcc ccgggtgcgt     1020

cccgtgcgag agagtgggga atacgtcacg gtgttgggtg ccagtctcgc caaacatggc     1080

tgtgcggcag cccggtgccc tcacgcaggg tctgcggacg cacatcgata tggttgtgat     1140

gtccgccacc ttctgctctg ctctctacgt gggggacctc tgtggcgggg tgatgctcgc     1200

ggcccaggtg ttcatcgtct cgccgcagta ccactggttt gtgcaagaat gcaattgctc     1260

catctaccct ggcaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggcc accatgatcc tggcgtacgt gatgcgcgtc cccgaggtca tcatagacat     1380

cgttagcggg gctcactggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaag gtcattgtca tccttctgct ggccgctggg gtggacgcgg gcaccaccac     1500

cgttggaggc gctgttgcac gttccaccaa cgtgattgcc ggcgtgttca gccatggccc     1560

tcagcagaac attcagctca ttaacaccaa cggcagttgg cacatcaacc gtactgcctt     1620

gaattgcaat gactccttga acaccggctt tctcgcggcc ttgttctaca ccaaccgctt     1680

taactcgtca gggtgtccag ggcgcctgtc cgcctgccgc aacatcgagg ctttccggat     1740

agggtggggc accctacagt acgaggataa tgtcaccaat ccagaggata tgaggccgta     1800

ctgctggcac taccccccaa agccgtgtgg cgtagtcccc gcgaggtctg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccggtagt agtgggcacg accgacagac gtggagtgcc     1920

cacctacaca tggggagaga atgagacaga tgtcttccta ctgaacagca cccgaccgcc     1980

gcagggctca tggttcggct gcacgtggat gaactccact ggtttcacca agacttgtgg     2040

cgcgccacct tgccgcacca gagctgactt caacgccagc acggacttgt tgtgccctac     2100

ggattgtttt aggaagcatc ctgatgccac ttatattaag tgtggttctg ggccctggct     2160

cacaccaaag tgcctggtcc actaccctta cagactctgg cattacccct gcacagtcaa     2220

ttttaccatc ttcaagataa gaatgtatgt agggggggtt gagcacaggc tcacggccgc     2280

atgcaacttc actcgtgggg atcgctgcga cttggaggac agggacagga gtcagctgtc     2340

tcctctgttg cactctacca cggaatgggc catcctgccc tgcacctact cagacttacc     2400

cgctttgtca actggtcttc tccaccttca ccagaacatc gtggacgtac aatacatgta     2460

tggcctctca cctgctatca caaaatacgt cgttcgatgg gagtgggtgg tactcttatt     2520

cctgctctta gcggacgcca gagtctgcgc ctgcttgtgg atgctcatct tgttgggcca     2580

ggccgaagca gcattggaga agttggtcgt cttgcacgct gcgagtgcgg ctaactgcca     2640

tggcctccta tattttgcca tcttcttcgt ggcagcttgg cacatcaggg gtcgggtggt     2700

ccccttgacc acctattgcc tcactggcct atggcccttc tgcctactgc tcatggcact     2760

gccccggcag gcttatgcct atgacgcacc tgtgcacgga cagataggcg tgggtttgtt     2820

gatattgatc accctcttca cactcacccc ggggtataag accctcctcg gccagtgtct     2880

gtggtggttg tgctatctcc tgaccctggg ggaagccatg attcaggagt gggtaccacc     2940

catgcaggtg cgcggcggcc gcgatggcat cgcgtgggcc gtcactatat tctgcccggg     3000

tgtggtgttt gacattacca aatggctttt ggcgttgctt gggcctgctt acctcttaag     3060

ggccgctttg acacatgtgc cgtacttcgt cagagctcac gctctgataa gggtatgcgc     3120

tttggtgaag cagctcgcgg ggggtaggta tgttcaggtg gcgctattgg cccttggcag     3180

gtggactggc acctacatct atgaccacct cacacctatg tcggactggg ccgctagcgg     3240

cctgcgcgac ttagcggtcg ccgtggaacc catcatcttc agtccgatgg agaagaaggt     3300

catcgtctgg ggagcggaga cggctgcatg tggggacatt ctacatggac ttcccgtgtc     3360

cgcccgactc ggccaggaga tcctcctcgg cccagctgat ggctacacct ccaaggggtg     3420

gaagctcctt gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgctc cggatcctgg ctccgcgacg tgtgggactg     6300

ggtttgcacc atcttgacag acttcaaaaa ttggctgacc tctaaattgt tccccaagct     6360

gcccggcctc cccttcatct cttgtcaaaa ggggtacaag ggtgtgtggg ccggcactgg     6420

catcatgacc acgcgctgcc cttgcggcgc caacatctct ggcaatgtcc gcctgggctc     6480

tatgaggatc acagggccta aaacctgcat gaacacctgg caggggacct ttcctatcaa     6540

ttgctacacg gagggccagt gcgcgccgaa accccccacg aactacaaga ccgccatctg     6600

gagggtggcg gcctcggagt acgcggaggt gacgcagcat gggtcgtact cctatgtaac     6660

aggactgacc actgacaatc tgaaaattcc ttgccaacta ccttctccag agtttttctc     6720

ctgggtggac ggtgtgcaga tccataggtt tgcacccaca ccaaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc ctatgctgtc gggtcccagc ttccctgtga     6840

acctgagccc gacgcagacg tattgaggtc catgctaaca gatccgcccc acatcacggc     6900

ggagactgcg gcgcggcgct tggcacgggg atcacctcca tctgaggcga gctcctcagt     6960

gagccagcta tcagcaccgt cgctgcgggc cacctgcacc acccacagca acacctatga     7020

cgtggacatg gtcgatgcca acctgctcat ggagggcggt gtggctcaga cagagcctga     7080

gtccagggtg cccgttctgg actttctcga gccaatggcc gaggaagaga gcgaccttga     7140

gccctcaata ccatcggagt gcatgctccc caggagcggg tttccacggg ccttaccggc     7200

ttgggcacgg cctgactaca acccgccgct cgtggaatcg tggaggaggc cagattacca     7260

accgcccacc gttgctggtt gtgctctccc cccccccaag aaggccccga cgcctccccc     7320

aaggagacgc cggacagtgg gtctgagcga gagcaccata tcagaagccc tccagcaact     7380

ggccatcaag acctttggcc agcccccctc gagcggtgat gcaggctcgt ccacgggggc     7440

gggcgccgcc gaatccggcg gtccgacgtc ccctggtgag ccggccccct cagagacagg     7500

ttccgcctcc tctatgcccc ccctcgaggg ggagcctgga gatccggacc tggagtctga     7560

tcaggtagag cttcaacctc ccccccaggg ggggggggta gctcccggtt cgggctcggg     7620

gtcttggtct acttgctccg aggaggacga taccaccgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccctgtag ccccgaagag gaaaagttgc caatcaaccc     7740

tttgagtaac tcgctgttgc gataccataa caaggtgtac tgtacaacat caaagagcgc     7800

ctcacagagg gctaaaaagg taacttttga caggacgcaa gtgctcgacg cccattatga     7860

ctcagtctta aaggacatca agctagcggc ttccaaggtc agcgcaaggc tcctcacctt     7920

ggaggaggcg tgccagttga ctccacccca ttctgcaaga tccaagtatg gattcggggc     7980

caaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggaa gacccacaaa caccaattcc cacaaccatc atggccaaaa atgaggtgtt     8100

ctgcgtggac cccgccaagg ggggtaagaa accagctcgc ctcatcgttt accctgacct     8160

cggcgtccgg gtctgcgaga aaatggccct ctatgacatt acacaaaagc ttcctcaggc     8220

ggtaatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg ccatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


