                               SEQUENCE LISTING

<110> GOLDENBERG, DAVID M.
      HANSEN, HANS J.
      CHANG, CHIEN-HSING
      GOLD, DAVID V.
 
<120> ANTI-PANCREATIC CANCER ANTIBODIES

<130> IMM313WO1

<140>
<141>

<150> 12/418,877
<151> 2009-04-06

<150> 61/144,227
<151> 2009-01-13

<150> 12/343,655
<151> 2008-12-24

<150> 61/087,463
<151> 2008-08-08


<160> 61    

<170> PatentIn version 3.5

<210> 1
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 1
Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu Tyr 
1               5                   10          


<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic humanized PAM4 
      antibody fragment

<400> 2
Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic humanized PAM4 
      antibody fragment 

<400> 3
His Gln Trp Asn Arg Tyr Pro Tyr Thr 
1               5                   


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 4
Ser Tyr Val Leu His 
1               5   


<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic humanized PAM4 
      antibody fragment 

<400> 5
Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic humanized PAM4 
      antibody fragment 

<400> 6
Gly Phe Gly Gly Ser Tyr Gly Phe Ala Tyr 
1               5                   10  


<210> 7
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 7
Phe Lys Tyr Lys 
1               


<210> 8
<211> 324
<212> DNA
<213> Mus sp.

<220>
<221> CDS
<222> (1)..(324)

<400> 8
gat att gtg atg acc cag tct cca gca atc atg tct gca tct cct ggg         48
Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly           
1               5                   10                  15                

gag aag gtc acc atg acc tgc agt gcc agc tca agt gta agt tcc agc         96
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser           
            20                  25                  30                    

tac ttg tac tgg tac cag cag aag cca gga tcc tcc ccc aaa ctc tgg        144
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp           
        35                  40                  45                        

att tat agc aca tcc aac ctg gct tct gga gtc cct gct cgc ttc agt        192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg acc tct tac tct ctc aca atc agc agc atg gag        240
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu           
65                  70                  75                  80            

gct gaa gat gct gcc tct tat ttc tgc cat cag tgg aat agg tac ccg        288
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Asn Arg Tyr Pro           
                85                  90                  95                

tac acg ttc gga ggg ggg acc aag ctg gaa ata aaa                        324
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys                           
            100                 105                                       


<210> 9
<211> 108
<212> PRT
<213> Mus sp.

<400> 9
Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Asn Arg Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 10
<211> 357
<212> DNA
<213> Mus sp.

<220>
<221> CDS
<222> (1)..(357)

<400> 10
gag gtt cag ctg cag gag tct gga cct gag ctg gta aag cct ggg gct         48
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag atg tcc tgc aag gct tct gga tac aca ttc cct agc tat         96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Ser Tyr           
            20                  25                  30                    

gtt ttg cac tgg gtg aag cag aag cct ggg cag ggc ctt gag tgg att        144
Val Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga tat att aat cct tac aat gat ggt act cag tac aat gag aag ttc        192
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Gln Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aaa ggc aag gcc aca ctg act tca gac aaa tcg tcc agc aca gcc tac        240
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc agc cgc ctg acc tct gag gac tct gcg gtc tat tac tgt        288
Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga ggc ttc ggt ggt agc tac gga ttt gct tac tgg ggc caa ggg        336
Ala Arg Gly Phe Gly Gly Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly           
            100                 105                 110                   

act ctg atc act gtc tct gca                                            357
Thr Leu Ile Thr Val Ser Ala                                               
        115                                                               


<210> 11
<211> 119
<212> PRT
<213> Mus sp.

<400> 11
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Ser Tyr 
            20                  25                  30          


Val Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Gly Gly Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Ile Thr Val Ser Ala 
        115                 


<210> 12
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 12
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Asn Arg Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210> 13
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 13
Gln Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Ser Tyr 
            20                  25                  30          


Val Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Gly Gly Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Ile Thr Val Ser Ser 
        115                 


<210> 14
<211> 107
<212> PRT
<213> Homo sapiens

<400> 14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Thr Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 15
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221> CDS
<222> (1)..(327)

<400> 15
gac atc cag ctg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atg acc tgc agt gcc agc tca agt gta agt tcc agc         96
Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser           
            20                  25                  30                    

tac ttg tac tgg tac caa cag aaa cca ggg aaa gcc ccc aaa ctc tgg        144
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp           
        35                  40                  45                        

att tat agc aca tcc aac ctg gct tct gga gtc cct gct cgc ttc agt        192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser           
    50                  55                  60                            

ggc agt gga tct ggg aca gac ttc act ctc acc atc agc agt ctg caa        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

cct gaa gat tct gcc tct tat ttc tgc cat cag tgg aat agg tac ccg        288
Pro Glu Asp Ser Ala Ser Tyr Phe Cys His Gln Trp Asn Arg Tyr Pro           
                85                  90                  95                

tac acg ttc gga ggg ggg aca cga ctg gag atc aaa cga                    327
Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys Arg                       
            100                 105                                       


<210> 16
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 16
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ser Ala Ser Tyr Phe Cys His Gln Trp Asn Arg Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105                 


<210> 17
<211> 108
<212> PRT
<213> Homo sapiens

<400> 17
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Arg Leu Leu Ala Asp Val Leu Leu 
            100                 105             


<210> 18
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<220>
<221> CDS
<222> (1)..(357)

<400> 18
cag gtg cag ctg cag cag tct ggg gct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc gag gct tct gga tac aca ttc cct agc tat         96
Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Pro Ser Tyr           
            20                  25                  30                    

gtt ttg cac tgg gtg aag cag gcc cct gga caa ggg ctt gag tgg att        144
Val Leu His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga tat att aat cct tac aat gat ggt act cag tac aat gag aag ttc        192
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Gln Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aaa ggc aag gcc aca ctg acc agg gac acg tcc atc aac aca gcc tac        240
Lys Gly Lys Ala Thr Leu Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg agc agg ctg aga tct gac gac acg gcc gtg tat tac tgt        288
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga ggc ttc ggt ggt agc tac gga ttt gct tac tgg ggc cag gga        336
Ala Arg Gly Phe Gly Gly Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tca                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                


<210> 19
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 19
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Pro Ser Tyr 
            20                  25                  30          


Val Leu His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Gly Gly Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 20
<211> 173
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<400> 20
agtctggggc tgaggtgaag aagcctgggg cctcagtgaa ggtctcctgc gaggcttctg       60

gatacacatt ccctagctat gttttgcact gggtgaagca ggcccctgga caagggcttg      120

agtggattgg atatattaat ccttacaatg atggtactca gtacaatgag aag             173


<210> 21
<211> 173
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<400> 21
agggttccct ggccccagta agcaaatccg tagctaccac cgaagcctct tgcacagtaa       60

tacacggccg tgtcgtcaga tctcagcctg ctcagctcca tgtaggctgt gttgatggac      120

gtgtccctgg tcagtgtggc cttgcctttg aacttctcat tgtactgagt acc             173


<210> 22
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 22
caggtgcagc tgcagcagtc tggggctgag gtga                                   34


<210> 23
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 23
tgaggagacg gtgaccaggg ttccctggcc cca                                    33


<210> 24
<211> 157
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<400> 24
cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatgac ctgcagtgcc       60

agctcaagtg taagttccag ctacttgtac tggtaccaac agaaaccagg gaaagccccc      120

aaactctgga tttatagcac atccaacctg gcttctg                               157


<210> 25
<211> 156
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<400> 25
gtcccccctc cgaacgtgta cgggtaccta ttccactgat ggcagaaata agaggcagaa       60

tcttcaggtt gcagactgct gatggtgaga gtgaagtctg tcccagatcc actgccactg      120

aagcgagcag ggactccaga agccaggttg gatgtg                                156


<210> 26
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 26
gacatccagc tgacccagtc tccatcctcc ctg                                    33


<210> 27
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 27
ttagatctcc agtcgtgtcc cccctccgaa cgt                                    33
    

<210> 28
<211> 11
<212> PRT
<213> Homo sapiens

<400> 28
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 29
Trp Thr Trp Asn Ile Thr Lys Ala Tyr Pro Leu Pro 
1               5                   10          


<210> 30
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 30
Ala Cys Pro Glu Trp Trp Gly Thr Thr Cys 
1               5                   10  


<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 31
Trp Thr Trp Asn Ile Thr Lys Glu Tyr Pro Gln Pro 
1               5                   10          


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 32
Gly Thr Thr Gly Thr Thr Cys 
1               5           


<210> 33
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 33
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 34
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 34
Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 35
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 36
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 36
Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210> 37
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 37
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 38
<211> 55
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 38
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Ile Gln Ile 
1               5                   10                  15      


Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr Thr Val Glu Val Leu 
            20                  25                  30          


Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala Val Glu Tyr Phe Thr 
        35                  40                  45              


Arg Leu Arg Glu Ala Arg Ala 
    50                  55  


<210> 39
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 39
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Glu Tyr 
1               5                   10                  15      


Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln Ala 
            20                  25                  


<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 40
Gly Gly Gly Gly Ser Gly Gly Gly Cys Gly 
1               5                   10  


<210> 41
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Cys(SS-tButhio)

<220>
<223> C-term amidated

<400> 41
Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210> 42
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Cys(SS-tButhio)

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Gly-EDANS
	
<400> 42
Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys Gly 
            20          


<210> 43
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide


<220>
<223> N-term acetylated

<220>
<221> MOD_RES
<222> (1)..(1)
<223> Cys-(polyethylene glycol)3

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Cys(S-tButhio)

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Cys(S-tButhio)

<220>
<223> C-term amidated

<400> 43
Cys Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala 
1               5                   10                  15      


Ile Gln Gln Ala Gly Cys Gly
            20             


<210> 44
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 44
Lys Ser His His His His His His Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu 
            20                  25                  30          


Gln Gly Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val 
        35                  40                  45              


Glu Phe Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
    50                  55                  60              


<210> 45
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 45
tctagacaca ggacctcatc atggccttga cctttgcttt actgg                       45


<210> 46
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 46
ggatccatga tggtgatgat ggtgtgactt ttccttactt cttaaacttt cttgc            55


<210> 47
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 47
agatctggcg cacctgaact cctg                                              24


<210> 48
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 48
gaattcggat cctttacccg gagacaggga gag                                    33


<210> 49
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 49
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp Tyr Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 50
Gln Ile Glu Tyr Lys Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 51
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 51
Gln Ile Glu Tyr His Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 52
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 52
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 53
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 53
Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala Val Ile Glu 
1               5                   10                  15      


Gln Val Lys Ala Ala Gly Ala Tyr 
            20                  


<210> 54
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 54
Leu Glu Gln Tyr Ala Asn Gln Leu Ala Asp Gln Ile Ile Lys Glu Ala 
1               5                   10                  15      


Thr Glu 
        


<210> 55
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 55
Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser Asp Val 
1               5                   10                  15      


Phe Gln Gln Cys 
            20  


<210> 56
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 56
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 57
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 57
Pro Glu Asp Ala Glu Leu Val Arg Thr Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 58
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 58
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Asp Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 59
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      6xHis tag

<400> 59
His His His His His His 
1               5       


<210> 60
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Asp

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Thr or Arg

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Lys, Arg, Thr, Asn or Gly

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Glu, Thr, Arg, Phe or Cys

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Tyr or Thr

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Pro or Arg

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu, Gln, Ile, Met or Cys

<400> 60
Trp Thr Trp Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Pro 
1               5                   10          


<210> 61
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Pro or Tyr

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Gly or Ser

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Thr, Gly or Ser

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Thr, Met, Ser, Gln or Pro

<400> 61
Ala Cys Xaa Glu Trp Trp Xaa Xaa Xaa Cys 
1               5                   10  


