
                                SEQUENCE LISTING

<110> Glaxo Wellcome Manufacturing Pte Ltd
      ZANG, Jingwu Z
      LU, Hongtao
      LI, Lixin
      LEUNG, Stewart
      LIU, Xuebin
      TSUI, Ping

<120> Treatment of Autoimmune and Inflammatory
  Disease

<130> PB63103

<150> US 61/087294        
<151> 2008-08-08  

<150> US 61/169801        
<151> 2009-04-16  

<150> US 61/218627        
<151> 2009-06-19  

<160> 126

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 459
<212> PRT
<213> Homo sapiens

<220> 
<223> Recombinant construct

<400> 1
Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln
 1               5                  10                  15      
Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp
            20                  25                  30          
Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val
        35                  40                  45              
Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val
    50                  55                  60                  
Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val
65                  70                  75                  80  
Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr
                85                  90                  95      
Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly
            100                 105                 110         
Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys
        115                 120                 125             
Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn
    130                 135                 140                 
Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val
145                 150                 155                 160 
Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn
                165                 170                 175     
Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln
            180                 185                 190         
Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile
        195                 200                 205             
Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr
    210                 215                 220                 
Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro
225                 230                 235                 240 
Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu
                245                 250                 255     
Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val
            260                 265                 270         
Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys
        275                 280                 285             
Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu
    290                 295                 300                 
Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val
305                 310                 315                 320 
Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu
                325                 330                 335     
Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu
            340                 345                 350         
Asp Val Val Val Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr
        355                 360                 365             
Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser
    370                 375                 380                 
Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val
385                 390                 395                 400 
Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro
                405                 410                 415     
Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala
            420                 425                 430         
Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala
        435                 440                 445             
Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln
    450                 455                 


<210> 2
<211> 117
<212> PRT
<213> Mus musculus

<220> 
<223> Murine Ab variable region sequence

<400> 2
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr
            20                  25                  30          
Asn Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Met Ile Trp Asp Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Arg Asn Arg Tyr Glu Ser Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 3
<211> 114
<212> PRT
<213> Mus musculus

<400> 3
Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Thr Val Thr Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Gly Asn Arg Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
                85                  90                  95      
Asp Tyr Thr Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys Arg
        


<210> 4
<211> 5
<212> PRT
<213> Mus musculus

<400> 4
Arg Tyr Asn Val His
 1               5  


<210> 5
<211> 16
<212> PRT
<213> Mus musculus

<400> 5
Met Ile Trp Asp Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser
 1               5                  10                  15      


<210> 6
<211> 6
<212> PRT
<213> Mus musculus

<400> 6
Asn Arg Tyr Glu Ser Gly
 1               5      


<210> 7
<211> 17
<212> PRT
<213> Mus musculus

<400> 7
Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Arg Lys Asn Tyr Leu
 1               5                  10                  15      
Thr
    


<210> 8
<211> 7
<212> PRT
<213> Mus musculus

<400> 8
Trp Ala Ser Thr Arg Glu Ser
 1               5          


<210> 9
<211> 12
<212> PRT
<213> Mus musculus

<400> 9
Gln Asn Asp Tyr Thr Tyr Pro Phe Thr Phe Gly Ser
 1               5                  10          


<210> 10
<211> 17
<212> PRT
<213> Mus musculus

<400> 10
Pro Ala Arg Gly Glu Ser Asn Trp Thr His Val Ser Leu Phe His Thr
 1               5                  10                  15      
Arg
    


<210> 11
<211> 16
<212> PRT
<213> Mus musculus

<400> 11
Val Lys Cys Leu Thr Leu Asn Lys Leu Gln Asp Ile Tyr Phe Ile Lys
 1               5                  10                  15      


<210> 12
<211> 30
<212> PRT
<213> Mus musculus

<400> 12
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser
            20                  25                  30  


<210> 13
<211> 14
<212> PRT
<213> Mus musculus

<400> 13
Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly
 1               5                  10                  


<210> 14
<211> 32
<212> PRT
<213> Mus musculus

<400> 14
Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
 1               5                  10                  15      
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 15
<211> 14
<212> PRT
<213> Mus musculus

<400> 15
Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
 1               5                  10                  


<210> 16
<211> 23
<212> PRT
<213> Mus musculus

<400> 16
Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Thr Val Thr Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys
            20              


<210> 17
<211> 15
<212> PRT
<213> Mus musculus

<400> 17
Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 18
<211> 32
<212> PRT
<213> Mus musculus

<400> 18
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Ile Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys
            20                  25                  30          


<210> 19
<211> 8
<212> PRT
<213> Mus musculus

<400> 19
Gly Thr Lys Leu Glu Ile Lys Arg
 1               5              


<210> 20
<211> 15
<212> PRT
<213> Homo sapiens

<400> 20
Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn
 1               5                  10                  15  


<210> 21
<211> 22
<212> PRT
<213> Homo sapiens

<400> 21
Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe
 1               5                  10                  15      
Leu Leu Ile Gly Lys Ser
            20          


<210> 22
<211> 10
<212> PRT
<213> Homo sapiens

<400> 22
Gln Glu Lys Asp Glu Asn Lys Trp Thr His
 1               5                  10  


<210> 23
<211> 15
<212> PRT
<213> Homo sapiens

<400> 23
Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile
 1               5                  10                  15  


<210> 24
<211> 15
<212> PRT
<213> Homo sapiens

<400> 24
Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val
 1               5                  10                  15  


<210> 25
<211> 15
<212> PRT
<213> Homo sapiens

<400> 25
Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu Ser
 1               5                  10                  15  


<210> 26
<211> 15
<212> PRT
<213> Homo sapiens

<400> 26
Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn
 1               5                  10                  15  


<210> 27
<211> 22
<212> PRT
<213> Homo sapiens

<400> 27
Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe
 1               5                  10                  15      
Leu Leu Ile Gly Lys Ser
            20          


<210> 28
<211> 42
<212> PRT
<213> Homo sapiens

<400> 28
Tyr Arg Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser His
 1               5                  10                  15      
Leu Gln Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala Tyr Arg
            20                  25                  30          
Gln Glu Lys Asp Glu Asn Lys Trp Thr His
        35                  40          


<210> 29
<211> 119
<212> PRT
<213> Mus musculus

<400> 29
Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ala Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Cys Thr Pro Ser Leu
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Ser
65                  70                  75                  80  
Leu Gln Met Asn Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Leu Arg Pro Phe Trp Tyr Phe Asp Val Trp Gly Ala Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115                 


<210> 30
<211> 112
<212> PRT
<213> Mus musculus

<400> 30
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Gln Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 31
<211> 5
<212> PRT
<213> Mus musculus

<400> 31
Ala Tyr Trp Met Ser
 1               5  


<210> 32
<211> 17
<212> PRT
<213> Mus musculus

<400> 32
Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Cys Thr Pro Ser Leu Lys
 1               5                  10                  15      
Asp
    


<210> 33
<211> 11
<212> PRT
<213> Mus musculus

<400> 33
Arg Leu Arg Pro Phe Trp Tyr Phe Asp Val Trp
 1               5                  10      


<210> 34
<211> 16
<212> PRT
<213> Mus musculus

<400> 34
Arg Ser Ser Gln Ser Ile Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu
 1               5                  10                  15      


<210> 35
<211> 7
<212> PRT
<213> Mus musculus

<400> 35
Lys Val Ser Asn Arg Phe Ser
 1               5          


<210> 36
<211> 9
<212> PRT
<213> Mus musculus

<400> 36
Phe Gln Gly Ser His Val Pro Arg Thr
 1               5                  


<210> 37
<211> 30
<212> PRT
<213> Mus musculus

<400> 37
Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser
            20                  25                  30  


<210> 38
<211> 14
<212> PRT
<213> Mus musculus

<400> 38
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
 1               5                  10                  


<210> 39
<211> 32
<212> PRT
<213> Mus musculus

<400> 39
Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Ser Leu Gln
 1               5                  10                  15      
Met Asn Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 40
<211> 10
<212> PRT
<213> Mus musculus

<400> 40
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
 1               5                  10  


<210> 41
<211> 23
<212> PRT
<213> Mus musculus

<400> 41
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys
            20              


<210> 42
<211> 15
<212> PRT
<213> Mus musculus

<400> 42
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 43
<211> 32
<212> PRT
<213> Mus musculus

<400> 43
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys
            20                  25                  30          


<210> 44
<211> 10
<212> PRT
<213> Mus musculus

<400> 44
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
 1               5                  10  


<210> 45
<211> 15
<212> PRT
<213> Homo sapiens

<400> 45
Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu
 1               5                  10                  15  


<210> 46
<211> 9
<212> PRT
<213> Homo sapiens

<400> 46
Leu Thr Cys Ala Phe Glu Asp Pro Asp
 1               5                  


<210> 47
<211> 11
<212> PRT
<213> Homo sapiens

<400> 47
Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu
 1               5                  10      


<210> 48
<211> 9
<212> PRT
<213> Homo sapiens

<400> 48
Leu Thr Cys Ala Phe Glu Asp Pro Asp
 1               5                  


<210> 49
<211> 15
<212> PRT
<213> Homo sapiens

<400> 49
Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu
 1               5                  10                  15  


<210> 50
<211> 12
<212> PRT
<213> Homo sapiens

<400> 50
Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Glu
 1               5                  10          


<210> 51
<211> 119
<212> PRT
<213> Mus musculus

<400> 51
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Thr Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Ile Phe Tyr Ser Gly Ser Thr Thr Tyr Thr Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly Tyr Asp Val Asn Tyr Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 52
<211> 107
<212> PRT
<213> Mus musculus

<400> 52
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Ala Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Thr Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
65                  70                  75                  80  
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Phe Phe Ser Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 53
<211> 6
<212> PRT
<213> Mus musculus

<400> 53
Thr Asp Tyr Ala Trp Asn
 1               5      


<210> 54
<211> 16
<212> PRT
<213> Mus musculus

<400> 54
Tyr Ile Phe Tyr Ser Gly Ser Thr Thr Tyr Thr Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 55
<211> 8
<212> PRT
<213> Mus musculus

<400> 55
Gly Gly Tyr Asp Val Asn Tyr Phe
 1               5              


<210> 56
<211> 11
<212> PRT
<213> Mus musculus

<400> 56
Leu Ala Ser Gln Thr Ile Gly Ala Trp Leu Ala
 1               5                  10      


<210> 57
<211> 7
<212> PRT
<213> Mus musculus

<400> 57
Ala Ala Thr Arg Leu Ala Asp
 1               5          


<210> 58
<211> 9
<212> PRT
<213> Mus musculus

<400> 58
Gln Gln Phe Phe Ser Thr Pro Trp Thr
 1               5                  


<210> 59
<211> 30
<212> PRT
<213> Mus musculus

<400> 59
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr
            20                  25                  30  


<210> 60
<211> 14
<212> PRT
<213> Mus musculus

<400> 60
Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly
 1               5                  10                  


<210> 61
<211> 32
<212> PRT
<213> Mus musculus

<400> 61
Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln
 1               5                  10                  15      
Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 62
<211> 13
<212> PRT
<213> Mus musculus

<400> 62
Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser
 1               5                  10              


<210> 63
<211> 23
<212> PRT
<213> Mus musculus

<400> 63
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Ser Val Thr Ile Thr Cys
            20              


<210> 64
<211> 15
<212> PRT
<213> Mus musculus

<400> 64
Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 65
<211> 32
<212> PRT
<213> Mus musculus

<400> 65
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Lys Phe Ser
 1               5                  10                  15      
Phe Lys Ile Ser Ser Leu Gln Ala Glu Asp Phe Val Ser Tyr Tyr Cys
            20                  25                  30          


<210> 66
<211> 10
<212> PRT
<213> Mus musculus

<400> 66
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
 1               5                  10  


<210> 67
<211> 12
<212> PRT
<213> Homo sapiens

<400> 67
Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu
 1               5                  10          


<210> 68
<211> 19
<212> PRT
<213> Homo sapiens

<400> 68
Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn
 1               5                  10                  15      
Ile Cys Val
            


<210> 69
<211> 12
<212> PRT
<213> Homo sapiens

<400> 69
Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu
 1               5                  10          


<210> 70
<211> 11
<212> PRT
<213> Homo sapiens

<400> 70
Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro
 1               5                  10      


<210> 71
<211> 119
<212> PRT
<213> Mus musculus

<400> 71
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Leu Lys Pro Gly Ala
 1               5                  10                  15      
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Asn Gly Val Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Ala Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115                 


<210> 72
<211> 105
<212> PRT
<213> Mus musculus

<400> 72
Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly
 1               5                  10                  15      
Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr
        35                  40                  45              
Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Ile Tyr Tyr Cys Gln Glu Trp Asn Tyr Pro Tyr Thr Phe
                85                  90                  95      
Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105 


<210> 73
<211> 5
<212> PRT
<213> Mus musculus

<400> 73
Gly Tyr Thr Met Asn
 1               5  


<210> 74
<211> 16
<212> PRT
<213> Mus musculus

<400> 74
Leu Ile Asn Pro Tyr Asn Gly Val Thr Ser Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      


<210> 75
<211> 8
<212> PRT
<213> Mus musculus

<400> 75
Gly Asp Gly Asn Tyr Trp Tyr Phe
 1               5              


<210> 76
<211> 11
<212> PRT
<213> Mus musculus

<400> 76
Ser Ala Ser Ser Ser Val Thr Tyr Met His Trp
 1               5                  10      


<210> 77
<211> 7
<212> PRT
<213> Mus musculus

<400> 77
Glu Ile Ser Lys Leu Ala Ser
 1               5          


<210> 78
<211> 9
<212> PRT
<213> Mus musculus

<400> 78
Gln Glu Trp Asn Tyr Pro Tyr Thr Phe
 1               5                  


<210> 79
<211> 30
<212> PRT
<213> Mus musculus

<400> 79
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Leu Lys Pro Gly Ala
 1               5                  10                  15      
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr
            20                  25                  30  


<210> 80
<211> 14
<212> PRT
<213> Mus musculus

<400> 80
Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile Gly
 1               5                  10                  


<210> 81
<211> 33
<212> PRT
<213> Mus musculus

<400> 81
Gly Lys Ala Thr Leu Thr Val Ala Lys Ser Ser Ser Thr Ala Tyr Met
 1               5                  10                  15      
Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala
            20                  25                  30          
Arg
    


<210> 82
<211> 13
<212> PRT
<213> Mus musculus

<400> 82
Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
 1               5                  10              


<210> 83
<211> 23
<212> PRT
<213> Mus musculus

<400> 83
Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly
 1               5                  10                  15      
Gln Lys Val Thr Ile Thr Cys
            20              


<210> 84
<211> 14
<212> PRT
<213> Mus musculus

<400> 84
Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr
 1               5                  10                  


<210> 85
<211> 32
<212> PRT
<213> Mus musculus

<400> 85
Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser
 1               5                  10                  15      
Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Ile Tyr Tyr Cys
            20                  25                  30          


<210> 86
<211> 9
<212> PRT
<213> Mus musculus

<400> 86
Gly Gly Gly Thr Lys Leu Glu Ile Lys
 1               5                  


<210> 87
<211> 21
<212> PRT
<213> Homo sapiens

<400> 87
Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile
 1               5                  10                  15      
Glu Thr Lys Lys Phe
            20      


<210> 88
<211> 7
<212> PRT
<213> Homo sapiens

<400> 88
Phe Asn Thr Ser His Leu Gln
 1               5          


<210> 89
<211> 14
<212> PRT
<213> Homo sapiens

<400> 89
Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp
 1               5                  10                  


<210> 90
<211> 119
<212> PRT
<213> Rattus

<400> 90
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Ser Gly Ile Thr Ser Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Leu Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115                 


<210> 91
<211> 105
<212> PRT
<213> Rattus

<400> 91
Glu Ile Ile Leu Thr Gln Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly
 1               5                  10                  15      
Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr
        35                  40                  45              
Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Ile Tyr Tyr Cys Gln Tyr Trp Asn Tyr Pro Tyr Thr Phe
                85                  90                  95      
Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105 


<210> 92
<211> 5
<212> PRT
<213> Rattus

<400> 92
Gly Tyr Thr Met Asn
 1               5  


<210> 93
<211> 16
<212> PRT
<213> Rattus

<400> 93
Leu Ile Asn Pro Tyr Ser Gly Ile Thr Ser Tyr Asn Gln Asn Phe Lys
 1               5                  10                  15      


<210> 94
<211> 8
<212> PRT
<213> Rattus

<400> 94
Gly Asp Gly Asn Tyr Trp Tyr Phe
 1               5              


<210> 95
<211> 11
<212> PRT
<213> Rattus

<400> 95
Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp
 1               5                  10      


<210> 96
<211> 7
<212> PRT
<213> Rattus

<400> 96
Glu Ile Ser Lys Leu Ala Ser
 1               5          


<210> 97
<211> 9
<212> PRT
<213> Rattus

<400> 97
Gln Tyr Trp Asn Tyr Pro Tyr Thr Phe
 1               5                  


<210> 98
<211> 30
<212> PRT
<213> Rattus

<400> 98
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr
            20                  25                  30  


<210> 99
<211> 14
<212> PRT
<213> Rattus

<400> 99
Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile Gly
 1               5                  10                  


<210> 100
<211> 33
<212> PRT
<213> Rattus

<400> 100
Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met
 1               5                  10                  15      
Glu Leu Leu Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala
            20                  25                  30          
Arg
    


<210> 101
<211> 13
<212> PRT
<213> Rattus

<400> 101
Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
 1               5                  10              


<210> 102
<211> 23
<212> PRT
<213> Rattus

<400> 102
Glu Ile Ile Leu Thr Gln Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly
 1               5                  10                  15      
Gln Lys Val Thr Ile Thr Cys
            20              


<210> 103
<211> 14
<212> PRT
<213> Rattus

<400> 103
Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr
 1               5                  10                  


<210> 104
<211> 32
<212> PRT
<213> Rattus

<400> 104
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser
 1               5                  10                  15      
Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Ile Tyr Tyr Cys
            20                  25                  30          


<210> 105
<211> 9
<212> PRT
<213> Rattus

<400> 105
Gly Gly Gly Thr Lys Leu Glu Ile Lys
 1               5                  


<210> 106
<211> 15
<212> PRT
<213> Homo sapiens

<400> 106
Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu
 1               5                  10                  15  


<210> 107
<211> 15
<212> PRT
<213> Homo sapiens

<400> 107
Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile
 1               5                  10                  15  


<210> 108
<211> 15
<212> PRT
<213> Homo sapiens

<400> 108
Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val
 1               5                  10                  15  


<210> 109
<211> 15
<212> PRT
<213> Homo sapiens

<400> 109
Leu Gln Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala Tyr
 1               5                  10                  15  


<210> 110
<211> 15
<212> PRT
<213> Homo sapiens

<400> 110
Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn
 1               5                  10                  15  


<210> 111
<211> 40
<212> PRT
<213> Homo sapiens

<400> 111
Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val
 1               5                  10                  15      
Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr
            20                  25                  30          
Lys Lys Phe Leu Leu Ile Gly Lys
        35                  40  


<210> 112
<211> 13
<212> PRT
<213> Homo sapiens

<400> 112
Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met His
 1               5                  10              


<210> 113
<211> 4
<212> PRT
<213> Homo sapiens

<400> 113
His Tyr Phe Lys
 1              


<210> 114
<211> 40
<212> PRT
<213> Homo sapiens

<400> 114
Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val
 1               5                  10                  15      
Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr
            20                  25                  30          
Lys Lys Phe Leu Leu Ile Gly Lys
        35                  40  


<210> 115
<211> 13
<212> PRT
<213> Homo sapiens

<400> 115
Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met His
 1               5                  10              


<210> 116
<211> 4
<212> PRT
<213> Homo sapiens

<400> 116
His Tyr Phe Lys
 1              


<210> 117
<211> 23
<212> PRT
<213> Homo sapiens

<400> 117
Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu Thr
 1               5                  10                  15      
Cys Ala Phe Glu Asp Pro Asp
            20              


<210> 118
<211> 16
<212> PRT
<213> Homo sapiens

<400> 118
Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val
 1               5                  10                  15      


<210> 119
<211> 22
<212> PRT
<213> Homo sapiens

<400> 119
Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe
 1               5                  10                  15      
Leu Leu Ile Gly Lys Ser
            20          


<210> 120
<211> 22
<212> PRT
<213> Homo sapiens

<400> 120
Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu
 1               5                  10                  15      
Met His Asp Val Ala Tyr
            20          


<210> 121
<211> 18
<212> PRT
<213> Homo sapiens

<400> 121
Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp
 1               5                  10                  15      
Ser Glu
        


<210> 122
<211> 3
<212> PRT
<213> Homo sapiens

<400> 122
Ser Gln His
 1          


<210> 123
<211> 3
<212> PRT
<213> Homo sapiens

<400> 123
Leu Val Glu
 1          


<210> 124
<211> 7
<212> PRT
<213> Homo sapiens

<400> 124
Lys Lys Phe Leu Leu Ile Gly
 1               5          


<210> 125
<211> 2
<212> PRT
<213> Homo sapiens

<400> 125
Lys Tyr
 1      


<210> 126
<211> 2
<212> PRT
<213> Homo sapiens

<400> 126
Tyr Phe
 1      

