                         SEQUENCE LISTING

<110>  Emory University
       Ahmed, Rafi
       Larsen, Christian P.
       Araki, Koichi
 
<120>  USE OF mTOR INHIBITORS TO ENHANCE T CELL IMMUNE RESPONSES

<130>  899-81120-01

<150>  US 61/086,350
<151>  2008-08-05

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
gcccgagtct gtgaatgtaa t                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
gccaaactga taatctcctc a                                                 21


<210>  3
<211>  8680
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (80)..(7729)

<400>  3
acggggcctg aagcggcggt accggtgctg gcggcggcag ctgaggcctt ggccgaagcc       60

gcgcgaacct cagggcaag atg ctt gga acc gga cct gcc gcc gcc acc acc       112
                     Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr          
                     1               5                   10               

gct gcc acc aca tct agc aat gtg agc gtc ctg cag cag ttt gcc agt        160
Ala Ala Thr Thr Ser Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser           
            15                  20                  25                    

ggc cta aag agc cgg aat gag gaa acc agg gcc aaa gcc gcc aag gag        208
Gly Leu Lys Ser Arg Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu           
        30                  35                  40                        

ctc cag cac tat gtc acc atg gaa ctc cga gag atg agt caa gag gag        256
Leu Gln His Tyr Val Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu           
    45                  50                  55                            

tct act cgc ttc tat gac caa ctg aac cat cac att ttt gaa ttg gtt        304
Ser Thr Arg Phe Tyr Asp Gln Leu Asn His His Ile Phe Glu Leu Val           
60                  65                  70                  75            

tcc agc tca gat gcc aat gag agg aaa ggt ggc atc ttg gcc ata gct        352
Ser Ser Ser Asp Ala Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala           
                80                  85                  90                

agc ctc ata gga gtg gaa ggt ggg aat gcc acc cga att ggc aga ttt        400
Ser Leu Ile Gly Val Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe           
            95                  100                 105                   

gcc aac tat ctt cgg aac ctc ctc ccc tcc aat gac cca gtt gtc atg        448
Ala Asn Tyr Leu Arg Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met           
        110                 115                 120                       

gaa atg gca tcc aag gcc att ggc cgt ctt gcc atg gca ggg gac act        496
Glu Met Ala Ser Lys Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr           
    125                 130                 135                           

ttt acc gct gag tac gtg gaa ttt gag gtg aag cga gcc ctg gaa tgg        544
Phe Thr Ala Glu Tyr Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp           
140                 145                 150                 155           

ctg ggt gct gac cgc aat gag ggc cgg aga cat gca gct gtc ctg gtt        592
Leu Gly Ala Asp Arg Asn Glu Gly Arg Arg His Ala Ala Val Leu Val           
                160                 165                 170               

ctc cgt gag ctg gcc atc agc gtc cct acc ttc ttc ttc cag caa gtg        640
Leu Arg Glu Leu Ala Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val           
            175                 180                 185                   

caa ccc ttc ttt gac aac att ttt gtg gcc gtg tgg gac ccc aaa cag        688
Gln Pro Phe Phe Asp Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln           
        190                 195                 200                       

gcc atc cgt gag gga gct gta gcc gcc ctt cgt gcc tgt ctg att ctc        736
Ala Ile Arg Glu Gly Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu           
    205                 210                 215                           

aca acc cag cgt gag ccg aag gag atg cag aag cct cag tgg tac agg        784
Thr Thr Gln Arg Glu Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg           
220                 225                 230                 235           

cac aca ttt gaa gaa gca gag aag gga ttt gat gag acc ttg gcc aaa        832
His Thr Phe Glu Glu Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys           
                240                 245                 250               

gag aag ggc atg aat cgg gat gat cgg atc cat gga gcc ttg ttg atc        880
Glu Lys Gly Met Asn Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile           
            255                 260                 265                   

ctt aac gag ctg gtc cga atc agc agc atg gag gga gag cgt ctg aga        928
Leu Asn Glu Leu Val Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg           
        270                 275                 280                       

gaa gaa atg gaa gaa atc aca cag cag cag ctg gta cac gac aag tac        976
Glu Glu Met Glu Glu Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr           
    285                 290                 295                           

tgc aaa gat ctc atg ggc ttc gga aca aaa cct cgt cac att acc ccc       1024
Cys Lys Asp Leu Met Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro           
300                 305                 310                 315           

ttc acc agt ttc cag gct gta cag ccc cag cag tca aat gcc ttg gtg       1072
Phe Thr Ser Phe Gln Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val           
                320                 325                 330               

ggg ctg ctg ggg tac agc tct cac caa ggc ctc atg gga ttt ggg acc       1120
Gly Leu Leu Gly Tyr Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr           
            335                 340                 345                   

tcc ccc agt cca gct aag tcc acc ctg gtg gag agc cgg tgt tgc aga       1168
Ser Pro Ser Pro Ala Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg           
        350                 355                 360                       

gac ttg atg gag gag aaa ttt gat cag gtg tgc cag tgg gtg ctg aaa       1216
Asp Leu Met Glu Glu Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys           
    365                 370                 375                           

tgc agg aat agc aag aac tcg ctg atc caa atg aca atc ctt aat ttg       1264
Cys Arg Asn Ser Lys Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu           
380                 385                 390                 395           

ttg ccc cgc ttg gct gca ttc cga cct tct gcc ttc aca gat acc cag       1312
Leu Pro Arg Leu Ala Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln           
                400                 405                 410               

tat ctc caa gat acc atg aac cat gtc cta agc tgt gtc aag aag gag       1360
Tyr Leu Gln Asp Thr Met Asn His Val Leu Ser Cys Val Lys Lys Glu           
            415                 420                 425                   

aag gaa cgt aca gcg gcc ttc caa gcc ctg ggg cta ctt tct gtg gct       1408
Lys Glu Arg Thr Ala Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala           
        430                 435                 440                       

gtg agg tct gag ttt aag gtc tat ttg cct cgc gtg ctg gac atc atc       1456
Val Arg Ser Glu Phe Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile           
    445                 450                 455                           

cga gcg gcc ctg ccc cca aag gac ttc gcc cat aag agg cag aag gca       1504
Arg Ala Ala Leu Pro Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala           
460                 465                 470                 475           

atg cag gtg gat gcc aca gtc ttc act tgc atc agc atg ctg gct cga       1552
Met Gln Val Asp Ala Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg           
                480                 485                 490               

gca atg ggg cca ggc atc cag cag gat atc aag gag ctg ctg gag ccc       1600
Ala Met Gly Pro Gly Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro           
            495                 500                 505                   

atg ctg gca gtg gga cta agc cct gcc ctc act gca gtg ctc tac gac       1648
Met Leu Ala Val Gly Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp           
        510                 515                 520                       

ctg agc cgt cag att cca cag cta aag aag gac att caa gat ggg cta       1696
Leu Ser Arg Gln Ile Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu           
    525                 530                 535                           

ctg aaa atg ctg tcc ctg gtc ctt atg cac aaa ccc ctt cgc cac cca       1744
Leu Lys Met Leu Ser Leu Val Leu Met His Lys Pro Leu Arg His Pro           
540                 545                 550                 555           

ggc atg ccc aag ggc ctg gcc cat cag ctg gcc tct cct ggc ctc acg       1792
Gly Met Pro Lys Gly Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr           
                560                 565                 570               

acc ctc cct gag gcc agc gat gtg ggc agc atc act ctt gcc ctc cga       1840
Thr Leu Pro Glu Ala Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg           
            575                 580                 585                   

acg ctt ggc agc ttt gaa ttt gaa ggc cac tct ctg acc caa ttt gtt       1888
Thr Leu Gly Ser Phe Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val           
        590                 595                 600                       

cgc cac tgt gcg gat cat ttc ctg aac agt gag cac aag gag atc cgc       1936
Arg His Cys Ala Asp His Phe Leu Asn Ser Glu His Lys Glu Ile Arg           
    605                 610                 615                           

atg gag gct gcc cgc acc tgc tcc cgc ctg ctc aca ccc tcc atc cac       1984
Met Glu Ala Ala Arg Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His           
620                 625                 630                 635           

ctc atc agt ggc cat gct cat gtg gtt agc cag acc gca gtg caa gtg       2032
Leu Ile Ser Gly His Ala His Val Val Ser Gln Thr Ala Val Gln Val           
                640                 645                 650               

gtg gca gat gtg ctt agc aaa ctg ctc gta gtt ggg ata aca gat cct       2080
Val Ala Asp Val Leu Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro           
            655                 660                 665                   

gac cct gac att cgc tac tgt gtc ttg gcg tcc ctg gac gag cgc ttt       2128
Asp Pro Asp Ile Arg Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe           
        670                 675                 680                       

gat gca cac ctg gcc cag gcg gag aac ttg cag gcc ttg ttt gtg gct       2176
Asp Ala His Leu Ala Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala           
    685                 690                 695                           

ctg aat gac cag gtg ttt gag atc cgg gag ctg gcc atc tgc act gtg       2224
Leu Asn Asp Gln Val Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val           
700                 705                 710                 715           

ggc cga ctc agt agc atg aac cct gcc ttt gtc atg cct ttc ctg cgc       2272
Gly Arg Leu Ser Ser Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg           
                720                 725                 730               

aag atg ctc atc cag att ttg aca gag ttg gag cac agt ggg att gga       2320
Lys Met Leu Ile Gln Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly           
            735                 740                 745                   

aga atc aaa gag cag agt gcc cgc atg ctg ggg cac ctg gtc tcc aat       2368
Arg Ile Lys Glu Gln Ser Ala Arg Met Leu Gly His Leu Val Ser Asn           
        750                 755                 760                       

gcc ccc cga ctc atc cgc ccc tac atg gag cct att ctg aag gca tta       2416
Ala Pro Arg Leu Ile Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu           
    765                 770                 775                           

att ttg aaa ctg aaa gat cca gac cct gat cca aac cca ggt gtg atc       2464
Ile Leu Lys Leu Lys Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile           
780                 785                 790                 795           

aat aat gtc ctg gca aca ata gga gaa ttg gca cag gtt agt ggc ctg       2512
Asn Asn Val Leu Ala Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu           
                800                 805                 810               

gaa atg agg aaa tgg gtt gat gaa ctt ttt att atc atc atg gac atg       2560
Glu Met Arg Lys Trp Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met           
            815                 820                 825                   

ctc cag gat tcc tct ttg ttg gcc aaa agg cag gtg gct ctg tgg acc       2608
Leu Gln Asp Ser Ser Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr           
        830                 835                 840                       

ctg gga cag ttg gtg gcc agc act ggc tat gta gta gag ccc tac agg       2656
Leu Gly Gln Leu Val Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg           
    845                 850                 855                           

aag tac cct act ttg ctt gag gtg cta ctg aat ttt ctg aag act gag       2704
Lys Tyr Pro Thr Leu Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu           
860                 865                 870                 875           

cag aac cag ggt aca cgc aga gag gcc atc cgt gtg tta ggg ctt tta       2752
Gln Asn Gln Gly Thr Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu           
                880                 885                 890               

ggg gct ttg gat cct tac aag cac aaa gtg aac att ggc atg ata gac       2800
Gly Ala Leu Asp Pro Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp           
            895                 900                 905                   

cag tcc cgg gat gcc tct gct gtc agc ctg tca gaa tcc aag tca agt       2848
Gln Ser Arg Asp Ala Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser           
        910                 915                 920                       

cag gat tcc tct gac tat agc act agt gaa atg ctg gtc aac atg gga       2896
Gln Asp Ser Ser Asp Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly           
    925                 930                 935                           

aac ttg cct ctg gat gag ttc tac cca gct gtg tcc atg gtg gcc ctg       2944
Asn Leu Pro Leu Asp Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu           
940                 945                 950                 955           

atg cgg atc ttc cga gac cag tca ctc tct cat cat cac acc atg gtt       2992
Met Arg Ile Phe Arg Asp Gln Ser Leu Ser His His His Thr Met Val           
                960                 965                 970               

gtc cag gcc atc acc ttc atc ttc aag tcc ctg gga ctc aaa tgt gtg       3040
Val Gln Ala Ile Thr Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val           
            975                 980                 985                   

cag ttc ctg ccc cag gtc atg ccc acg ttc ctt aac gtc  att cga gtc      3088
Gln Phe Leu Pro Gln Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val          
        990                 995                 1000                      

tgt gat  ggg gcc atc cgg gaa  ttt ttg ttc cag cag  ctg gga atg        3133
Cys Asp  Gly Ala Ile Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met            
    1005                 1010                 1015                        

ttg gtg  tcc ttt gtg aag agc  cac atc aga cct tat  atg gat gaa        3178
Leu Val  Ser Phe Val Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu            
    1020                 1025                 1030                        

ata gtc  acc ctc atg aga gaa  ttc tgg gtc atg aac  acc tca att        3223
Ile Val  Thr Leu Met Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile            
    1035                 1040                 1045                        

cag agc  acg atc att ctt ctc  att gag caa att gtg  gta gct ctt        3268
Gln Ser  Thr Ile Ile Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu            
    1050                 1055                 1060                        

ggg ggt  gaa ttt aag ctc tac  ctg ccc cag ctg atc  cca cac atg        3313
Gly Gly  Glu Phe Lys Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met            
    1065                 1070                 1075                        

ctg cgt  gtc ttc atg cat gac  aac agc cca ggc cgc  att gtc tct        3358
Leu Arg  Val Phe Met His Asp  Asn Ser Pro Gly Arg  Ile Val Ser            
    1080                 1085                 1090                        

atc aag  tta ctg gct gca atc  cag ctg ttt ggc gcc  aac ctg gat        3403
Ile Lys  Leu Leu Ala Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp            
    1095                 1100                 1105                        

gac tac  ctg cat tta ctg ctg  cct cct att gtt aag  ttg ttt gat        3448
Asp Tyr  Leu His Leu Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp            
    1110                 1115                 1120                        

gcc cct  gaa gct cca ctg cca  tct cga aag gca gcg  cta gag act        3493
Ala Pro  Glu Ala Pro Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr            
    1125                 1130                 1135                        

gtg gac  cgc ctg acg gag tcc  ctg gat ttc act gac  tat gcc tcc        3538
Val Asp  Arg Leu Thr Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser            
    1140                 1145                 1150                        

cgg atc  att cac cct att gtt  cga aca ctg gac cag  agc cca gaa        3583
Arg Ile  Ile His Pro Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu            
    1155                 1160                 1165                        

ctg cgc  tcc aca gcc atg gac  acg ctg tct tca ctt  gtt ttt cag        3628
Leu Arg  Ser Thr Ala Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln            
    1170                 1175                 1180                        

ctg ggg  aag aag tac caa att  ttc att cca atg gtg  aat aaa gtt        3673
Leu Gly  Lys Lys Tyr Gln Ile  Phe Ile Pro Met Val  Asn Lys Val            
    1185                 1190                 1195                        

ctg gtg  cga cac cga atc aat  cat cag cgc tat gat  gtg ctc atc        3718
Leu Val  Arg His Arg Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile            
    1200                 1205                 1210                        

tgc aga  att gtc aag gga tac  aca ctt gct gat gaa  gag gag gat        3763
Cys Arg  Ile Val Lys Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp            
    1215                 1220                 1225                        

cct ttg  att tac cag cat cgg  atg ctt agg agt ggc  caa ggg gat        3808
Pro Leu  Ile Tyr Gln His Arg  Met Leu Arg Ser Gly  Gln Gly Asp            
    1230                 1235                 1240                        

gca ttg  gct agt gga cca gtg  gaa aca gga ccc atg  aag aaa ctg        3853
Ala Leu  Ala Ser Gly Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu            
    1245                 1250                 1255                        

cac gtc  agc acc atc aac ctc  caa aag gcc tgg ggc  gct gcc agg        3898
His Val  Ser Thr Ile Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg            
    1260                 1265                 1270                        

agg gtc  tcc aaa gat gac tgg  ctg gaa tgg ctg aga  cgg ctg agc        3943
Arg Val  Ser Lys Asp Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser            
    1275                 1280                 1285                        

ctg gag  ctg ctg aag gac tca  tca tcg ccc tcc ctg  cgc tcc tgc        3988
Leu Glu  Leu Leu Lys Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys            
    1290                 1295                 1300                        

tgg gcc  ctg gca cag gcc tac  aac ccg atg gcc agg  gat ctc ttc        4033
Trp Ala  Leu Ala Gln Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe            
    1305                 1310                 1315                        

aat gct  gca ttt gtg tcc tgc  tgg tct gaa ctg aat  gaa gat caa        4078
Asn Ala  Ala Phe Val Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln            
    1320                 1325                 1330                        

cag gat  gag ctc atc aga agc  atc gag ttg gcc ctc  acc tca caa        4123
Gln Asp  Glu Leu Ile Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln            
    1335                 1340                 1345                        

gac atc  gct gaa gtc aca cag  acc ctc tta aac ttg  gct gaa ttc        4168
Asp Ile  Ala Glu Val Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe            
    1350                 1355                 1360                        

atg gaa  cac agt gac aag ggc  ccc ctg cca ctg aga  gat gac aat        4213
Met Glu  His Ser Asp Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn            
    1365                 1370                 1375                        

ggc att  gtt ctg ctg ggt gag  aga gct gcc aag tgc  cga gca tat        4258
Gly Ile  Val Leu Leu Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr            
    1380                 1385                 1390                        

gcc aaa  gca cta cac tac aaa  gaa ctg gag ttc cag  aaa ggc ccc        4303
Ala Lys  Ala Leu His Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro            
    1395                 1400                 1405                        

acc cct  gcc att cta gaa tct  ctc atc agc att aat  aat aag cta        4348
Thr Pro  Ala Ile Leu Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu            
    1410                 1415                 1420                        

cag cag  ccg gag gca gcg gcc  gga gtg tta gaa tat  gcc atg aaa        4393
Gln Gln  Pro Glu Ala Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys            
    1425                 1430                 1435                        

cac ttt  gga gag ctg gag atc  cag gct acc tgg tat  gag aaa ctg        4438
His Phe  Gly Glu Leu Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu            
    1440                 1445                 1450                        

cac gag  tgg gag gat gcc ctt  gtg gcc tat gac aag  aaa atg gac        4483
His Glu  Trp Glu Asp Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp            
    1455                 1460                 1465                        

acc aac  aag gac gac cca gag  ctg atg ctg ggc cgc  atg cgc tgc        4528
Thr Asn  Lys Asp Asp Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys            
    1470                 1475                 1480                        

ctc gag  gcc ttg ggg gaa tgg  ggt caa ctc cac cag  cag tgc tgt        4573
Leu Glu  Ala Leu Gly Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys            
    1485                 1490                 1495                        

gaa aag  tgg acc ctg gtt aat  gat gag acc caa gcc  aag atg gcc        4618
Glu Lys  Trp Thr Leu Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala            
    1500                 1505                 1510                        

cgg atg  gct gct gca gct gca  tgg ggt tta ggt cag  tgg gac agc        4663
Arg Met  Ala Ala Ala Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser            
    1515                 1520                 1525                        

atg gaa  gaa tac acc tgt atg  atc cct cgg gac acc  cat gat ggg        4708
Met Glu  Glu Tyr Thr Cys Met  Ile Pro Arg Asp Thr  His Asp Gly            
    1530                 1535                 1540                        

gca ttt  tat aga gct gtg ctg  gca ctg cat cag gac  ctc ttc tcc        4753
Ala Phe  Tyr Arg Ala Val Leu  Ala Leu His Gln Asp  Leu Phe Ser            
    1545                 1550                 1555                        

ttg gca  caa cag tgc att gac  aag gcc agg gac ctg  ctg gat gct        4798
Leu Ala  Gln Gln Cys Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala            
    1560                 1565                 1570                        

gaa tta  act gcg atg gca gga  gag agt tac agt cgg  gca tat ggg        4843
Glu Leu  Thr Ala Met Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly            
    1575                 1580                 1585                        

gcc atg  gtt tct tgc cac atg  ctg tcc gag ctg gag  gag gtt atc        4888
Ala Met  Val Ser Cys His Met  Leu Ser Glu Leu Glu  Glu Val Ile            
    1590                 1595                 1600                        

cag tac  aaa ctt gtc ccc gag  cga cga gag atc atc  cgc cag atc        4933
Gln Tyr  Lys Leu Val Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile            
    1605                 1610                 1615                        

tgg tgg  gag aga ctg cag ggc  tgc cag cgt atc gta  gag gac tgg        4978
Trp Trp  Glu Arg Leu Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp            
    1620                 1625                 1630                        

cag aaa  atc ctt atg gtg cgg  tcc ctt gtg gtc agc  cct cat gaa        5023
Gln Lys  Ile Leu Met Val Arg  Ser Leu Val Val Ser  Pro His Glu            
    1635                 1640                 1645                        

gac atg  aga acc tgg ctc aag  tat gca agc ctg tgc  ggc aag agt        5068
Asp Met  Arg Thr Trp Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser            
    1650                 1655                 1660                        

ggc agg  ctg gct ctt gct cat  aaa act tta gtg ttg  ctc ctg gga        5113
Gly Arg  Leu Ala Leu Ala His  Lys Thr Leu Val Leu  Leu Leu Gly            
    1665                 1670                 1675                        

gtt gat  ccg tct cgg caa ctt  gac cat cct ctg cca  aca gtt cac        5158
Val Asp  Pro Ser Arg Gln Leu  Asp His Pro Leu Pro  Thr Val His            
    1680                 1685                 1690                        

cct cag  gtg acc tat gcc tac  atg aaa aac atg tgg  aag agt gcc        5203
Pro Gln  Val Thr Tyr Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala            
    1695                 1700                 1705                        

cgc aag  atc gat gcc ttc cag  cac atg cag cat ttt  gtc cag acc        5248
Arg Lys  Ile Asp Ala Phe Gln  His Met Gln His Phe  Val Gln Thr            
    1710                 1715                 1720                        

atg cag  caa cag gcc cag cat  gcc atc gct act gag  gac cag cag        5293
Met Gln  Gln Gln Ala Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln            
    1725                 1730                 1735                        

cat aag  cag gaa ctg cac aag  ctc atg gcc cga tgc  ttc ctg aaa        5338
His Lys  Gln Glu Leu His Lys  Leu Met Ala Arg Cys  Phe Leu Lys            
    1740                 1745                 1750                        

ctt gga  gag tgg cag ctg aat  cta cag ggc atc aat  gag agc aca        5383
Leu Gly  Glu Trp Gln Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr            
    1755                 1760                 1765                        

atc ccc  aaa gtg ctg cag tac  tac agc gcc gcc aca  gag cac gac        5428
Ile Pro  Lys Val Leu Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp            
    1770                 1775                 1780                        

cgc agc  tgg tac aag gcc tgg  cat gcg tgg gca gtg  atg aac ttc        5473
Arg Ser  Trp Tyr Lys Ala Trp  His Ala Trp Ala Val  Met Asn Phe            
    1785                 1790                 1795                        

gaa gct  gtg cta cac tac aaa  cat cag aac caa gcc  cgc gat gag        5518
Glu Ala  Val Leu His Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu            
    1800                 1805                 1810                        

aag aag  aaa ctg cgt cat gcc  agc ggg gcc aac atc  acc aac gcc        5563
Lys Lys  Lys Leu Arg His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala            
    1815                 1820                 1825                        

acc act  gcc gcc acc acg gcc  gcc act gcc acc acc  act gcc agc        5608
Thr Thr  Ala Ala Thr Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser            
    1830                 1835                 1840                        

acc gag  ggc agc aac agt gag  agc gag gcc gag agc  acc gag aac        5653
Thr Glu  Gly Ser Asn Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn            
    1845                 1850                 1855                        

agc ccc  acc cca tcg ccg ctg  cag aag aag gtc act  gag gat ctg        5698
Ser Pro  Thr Pro Ser Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu            
    1860                 1865                 1870                        

tcc aaa  acc ctc ctg atg tac  acg gtg cct gcc gtc  cag ggc ttc        5743
Ser Lys  Thr Leu Leu Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe            
    1875                 1880                 1885                        

ttc cgt  tcc atc tcc ttg tca  cga ggc aac aac ctc  cag gat aca        5788
Phe Arg  Ser Ile Ser Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr            
    1890                 1895                 1900                        

ctc aga  gtt ctc acc tta tgg  ttt gat tat ggt cac  tgg cca gat        5833
Leu Arg  Val Leu Thr Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp            
    1905                 1910                 1915                        

gtc aat  gag gcc tta gtg gag  ggg gtg aaa gcc atc  cag att gat        5878
Val Asn  Glu Ala Leu Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp            
    1920                 1925                 1930                        

acc tgg  cta cag gtt ata cct  cag ctc att gca aga  att gat acg        5923
Thr Trp  Leu Gln Val Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr            
    1935                 1940                 1945                        

ccc aga  ccc ttg gtg gga cgt  ctc att cac cag ctt  ctc aca gac        5968
Pro Arg  Pro Leu Val Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp            
    1950                 1955                 1960                        

att ggt  cgg tac cac ccc cag  gcc ctc atc tac cca  ctg aca gtg        6013
Ile Gly  Arg Tyr His Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val            
    1965                 1970                 1975                        

gct tct  aag tct acc acg aca  gcc cgg cac aat gca  gcc aac aag        6058
Ala Ser  Lys Ser Thr Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys            
    1980                 1985                 1990                        

att ctg  aag aac atg tgt gag  cac agc aac acc ctg  gtc cag cag        6103
Ile Leu  Lys Asn Met Cys Glu  His Ser Asn Thr Leu  Val Gln Gln            
    1995                 2000                 2005                        

gcc atg  atg gtg agc gag gag  ctg atc cga gtg gcc  atc ctc tgg        6148
Ala Met  Met Val Ser Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp            
    2010                 2015                 2020                        

cat gag  atg tgg cat gaa ggc  ctg gaa gag gca tct  cgt ttg tac        6193
His Glu  Met Trp His Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr            
    2025                 2030                 2035                        

ttt ggg  gaa agg aac gtg aaa  ggc atg ttt gag gtg  ctg gag ccc        6238
Phe Gly  Glu Arg Asn Val Lys  Gly Met Phe Glu Val  Leu Glu Pro            
    2040                 2045                 2050                        

ttg cat  gct atg atg gaa cgg  ggc ccc cag act ctg  aag gaa aca        6283
Leu His  Ala Met Met Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr            
    2055                 2060                 2065                        

tcc ttt  aat cag gcc tat ggt  cga gat tta atg gag  gcc caa gag        6328
Ser Phe  Asn Gln Ala Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu            
    2070                 2075                 2080                        

tgg tgc  agg aag tac atg aaa  tca ggg aat gtc aag  gac ctc acc        6373
Trp Cys  Arg Lys Tyr Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr            
    2085                 2090                 2095                        

caa gcc  tgg gac ctc tat tat  cat gtg ttc cga cga  atc tca aag        6418
Gln Ala  Trp Asp Leu Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys            
    2100                 2105                 2110                        

cag ctg  cct cag ctc aca tcc  tta gag ctg caa tat  gtt tcc cca        6463
Gln Leu  Pro Gln Leu Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro            
    2115                 2120                 2125                        

aaa ctt  ctg atg tgc cgg gac  ctt gaa ttg gct gtg  cca gga aca        6508
Lys Leu  Leu Met Cys Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr            
    2130                 2135                 2140                        

tat gac  ccc aac cag cca atc  att cgc att cag tcc  ata gca ccg        6553
Tyr Asp  Pro Asn Gln Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro            
    2145                 2150                 2155                        

tct ttg  caa gtc atc aca tcc  aag cag agg ccc cgg  aaa ttg aca        6598
Ser Leu  Gln Val Ile Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr            
    2160                 2165                 2170                        

ctt atg  ggc agc aac gga cat  gag ttt gtt ttc ctt  cta aaa ggc        6643
Leu Met  Gly Ser Asn Gly His  Glu Phe Val Phe Leu  Leu Lys Gly            
    2175                 2180                 2185                        

cat gaa  gat ctg cgc cag gat  gag cgt gtg atg cag  ctc ttc ggc        6688
His Glu  Asp Leu Arg Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly            
    2190                 2195                 2200                        

ctg gtt  aac acc ctt ctg gcc  aat gac cca aca tct  ctt cgg aaa        6733
Leu Val  Asn Thr Leu Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys            
    2205                 2210                 2215                        

aac ctc  agc atc cag aga tac  gct gtc atc cct tta  tcg acc aac        6778
Asn Leu  Ser Ile Gln Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn            
    2220                 2225                 2230                        

tcg ggc  ctc att ggc tgg gtt  ccc cac tgt gac aca  ctg cac gcc        6823
Ser Gly  Leu Ile Gly Trp Val  Pro His Cys Asp Thr  Leu His Ala            
    2235                 2240                 2245                        

ctc atc  cgg gac tac agg gag  aag aag aag atc ctt  ctc aac atc        6868
Leu Ile  Arg Asp Tyr Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile            
    2250                 2255                 2260                        

gag cat  cgc atc atg ttg cgg  atg gct ccg gac tat  gac cac ttg        6913
Glu His  Arg Ile Met Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu            
    2265                 2270                 2275                        

act ctg  atg cag aag gtg gag  gtg ttt gag cat gcc  gtc aat aat        6958
Thr Leu  Met Gln Lys Val Glu  Val Phe Glu His Ala  Val Asn Asn            
    2280                 2285                 2290                        

aca gct  ggg gac gac ctg gcc  aag ctg ctg tgg ctg  aaa agc ccc        7003
Thr Ala  Gly Asp Asp Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro            
    2295                 2300                 2305                        

agc tcc  gag gtg tgg ttt gac  cga aga acc aat tat  acc cgt tct        7048
Ser Ser  Glu Val Trp Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser            
    2310                 2315                 2320                        

tta gcg  gtc atg tca atg gtt  ggg tat att tta ggc  ctg gga gat        7093
Leu Ala  Val Met Ser Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp            
    2325                 2330                 2335                        

aga cac  cca tcc aac ctg atg  ctg gac cgt ctg agt  ggg aag atc        7138
Arg His  Pro Ser Asn Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile            
    2340                 2345                 2350                        

ctg cac  att gac ttt ggg gac  tgc ttt gag gtt gct  atg acc cga        7183
Leu His  Ile Asp Phe Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg            
    2355                 2360                 2365                        

gag aag  ttt cca gag aag att  cca ttt aga cta aca  aga atg ttg        7228
Glu Lys  Phe Pro Glu Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu            
    2370                 2375                 2380                        

acc aat  gct atg gag gtt aca  ggc ctg gat ggc aac  tac aga atc        7273
Thr Asn  Ala Met Glu Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile            
    2385                 2390                 2395                        

aca tgc  cac aca gtg atg gag  gtg ctg cga gag cac  aag gac agt        7318
Thr Cys  His Thr Val Met Glu  Val Leu Arg Glu His  Lys Asp Ser            
    2400                 2405                 2410                        

gtc atg  gcc gtg ctg gaa gcc  ttt gtc tat gac ccc  ttg ctg aac        7363
Val Met  Ala Val Leu Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn            
    2415                 2420                 2425                        

tgg agg  ctg atg gac aca aat  acc aaa ggc aac aag  cga tcc cga        7408
Trp Arg  Leu Met Asp Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg            
    2430                 2435                 2440                        

acg agg  acg gat tcc tac tct  gct ggc cag tca gtc  gaa att ttg        7453
Thr Arg  Thr Asp Ser Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu            
    2445                 2450                 2455                        

gac ggt  gtg gaa ctt gga gag  cca gcc cat aag aaa  acg ggg acc        7498
Asp Gly  Val Glu Leu Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr            
    2460                 2465                 2470                        

aca gtg  cca gaa tct att cat  tct ttc att gga gac  ggt ttg gtg        7543
Thr Val  Pro Glu Ser Ile His  Ser Phe Ile Gly Asp  Gly Leu Val            
    2475                 2480                 2485                        

aaa cca  gag gcc cta aat aag  aaa gct atc cag att  att aac agg        7588
Lys Pro  Glu Ala Leu Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg            
    2490                 2495                 2500                        

gtt cga  gat aag ctc act ggt  cgg gac ttc tct cat  gat gac act        7633
Val Arg  Asp Lys Leu Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr            
    2505                 2510                 2515                        

ttg gat  gtt cca acg caa gtt  gag ctg ctc atc aaa  caa gcg aca        7678
Leu Asp  Val Pro Thr Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr            
    2520                 2525                 2530                        

tcc cat  gaa aac ctc tgc cag  tgc tat att ggc tgg  tgc cct ttc        7723
Ser His  Glu Asn Leu Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe            
    2535                 2540                 2545                        

tgg taa ctggaggccc agatgtgccc atcacgtttt ttctgaggct tttgtacttt        7779
Trp                                                                       
                                                                          

agtaaatgct tccactaaac tgaaaccatg gtgagaaagt ttgactttgt taaatatttt     7839

gaaatgtaaa tgaaaagaac tactgtatat taaaagttgg tttgaaccaa ctttctagct     7899

gctgttgaag aatatattgt cagaaacaca aggcttgatt tggttcccag gacagtgaaa     7959

caatagtaat accacgtaaa tcaagccatt cattttgggg aacagaagat ccataacttt     8019

agaaatacgg gttttgactt aactcacaag agaactcatc ataagtactt gctgatggaa     8079

gaatgaccta gttgctcctc tcaacatggg tacagcaaac tcagcacagc caagaagcct     8139

caggtcgtgg agaacatgga ttaggatcct agactgtaaa gacacagaag atgctgacct     8199

cacccctgcc acctatccca agacctcact ggtctgtgga cagcagcaga aatgtttgca     8259

agataggcca aaatgagtac aaaaggtctg tcttccatca gacccagtga tgctgcgact     8319

cacacgcttc aattcaagac ctgaccgcta gtagggaggt ttattcagat cgctggcagc     8379

ctcggctgag cagatgcaca gaggggatca ctgtgcagtg ggaccaccct cactggcctt     8439

ctgcagcagg gttctgggat gttttcagtg gtcaaaatac tctgtttaga gcaagggctc     8499

agaaaacaga aatactgtca tggaggtgct gaacacaggg aaggtctggt acatattgga     8559

aattatgagc agaacaaata ctcaactaaa tgcacaaagt ataaagtgta gccatgtcta     8619

gacaccatgt tgtatcagaa taatttttgt gccaataaat gacatcagaa ttttaaacat     8679

a                                                                     8680


<210>  4
<211>  2549
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210>  5
<211>  8155
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (19)..(7668)

<400>  5
cgcgaacctc agggcaag atg ctt gga acc gga cct gcc gcc gcc acc acc         51
                    Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr           
                    1               5                   10                

gct gcc acc aca tct agc aat gtg agc gtc ctg cag cag ttt gcc agt         99
Ala Ala Thr Thr Ser Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser           
            15                  20                  25                    

ggc cta aag agc cgg aat gag gaa acc agg gcc aaa gcc gcc aag gag        147
Gly Leu Lys Ser Arg Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu           
        30                  35                  40                        

ctc cag cac tat gtc acc atg gaa ctc cga gag atg agt caa gag gag        195
Leu Gln His Tyr Val Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu           
    45                  50                  55                            

tct act cgc ttc tat gac caa ctg aac cat cac att ttt gaa ttg gtt        243
Ser Thr Arg Phe Tyr Asp Gln Leu Asn His His Ile Phe Glu Leu Val           
60                  65                  70                  75            

tcc agc tca gat gcc aat gag agg aaa ggt ggc atc ttg gcc ata gct        291
Ser Ser Ser Asp Ala Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala           
                80                  85                  90                

agc ctc ata gga gtg gaa ggt ggg aat gcc acc cga att ggc aga ttt        339
Ser Leu Ile Gly Val Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe           
            95                  100                 105                   

gcc aac tat ctt cgg aac ctc ctc ccc tcc aat gac cca gtt gtc atg        387
Ala Asn Tyr Leu Arg Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met           
        110                 115                 120                       

gaa atg gca tcc aag gcc att ggc cgt ctt gcc atg gca ggg gac act        435
Glu Met Ala Ser Lys Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr           
    125                 130                 135                           

ttt acc gct gag tac gtg gaa ttt gag gtg aag cga gcc ctg gaa tgg        483
Phe Thr Ala Glu Tyr Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp           
140                 145                 150                 155           

ctg ggt gct gac cgc aat gag ggc cgg aga cat gca gct gtc ctg gtt        531
Leu Gly Ala Asp Arg Asn Glu Gly Arg Arg His Ala Ala Val Leu Val           
                160                 165                 170               

ctc cgt gag ctg gcc atc agc gtc cct acc ttc ttc ttc cag caa gtg        579
Leu Arg Glu Leu Ala Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val           
            175                 180                 185                   

caa ccc ttc ttt gac aac att ttt gtg gcc gtg tgg gac ccc aaa cag        627
Gln Pro Phe Phe Asp Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln           
        190                 195                 200                       

gcc atc cgt gag gga gct gta gcc gcc ctt cgt gcc tgt ctg att ctc        675
Ala Ile Arg Glu Gly Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu           
    205                 210                 215                           

aca acc cag cgt gag ccg aag gag atg cag aag cct cag tgg tac agg        723
Thr Thr Gln Arg Glu Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg           
220                 225                 230                 235           

cac aca ttt gaa gaa gca gag aag gga ttt gat gag acc ttg gcc aaa        771
His Thr Phe Glu Glu Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys           
                240                 245                 250               

gag aag ggc atg aat cgg gat gat cgg atc cat gga gcc ttg ttg atc        819
Glu Lys Gly Met Asn Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile           
            255                 260                 265                   

ctt aac gag ctg gtc cga atc agc agc atg gag gga gag cgt ctg aga        867
Leu Asn Glu Leu Val Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg           
        270                 275                 280                       

gaa gaa atg gaa gaa atc aca cag cag cag ctg gta cac gac aag tac        915
Glu Glu Met Glu Glu Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr           
    285                 290                 295                           

tgc aaa gat ctc atg ggc ttc gga aca aaa cct cgt cac att acc ccc        963
Cys Lys Asp Leu Met Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro           
300                 305                 310                 315           

ttc acc agt ttc cag gct gta cag ccc cag cag tca aat gcc ttg gtg       1011
Phe Thr Ser Phe Gln Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val           
                320                 325                 330               

ggg ctg ctg ggg tac agc tct cac caa ggc ctc atg gga ttt ggg acc       1059
Gly Leu Leu Gly Tyr Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr           
            335                 340                 345                   

tcc ccc agt cca gct aag tcc acc ctg gtg gag agc cgg tgt tgc aga       1107
Ser Pro Ser Pro Ala Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg           
        350                 355                 360                       

gac ttg atg gag gag aaa ttt gat cag gtg tgc cag tgg gtg ctg aaa       1155
Asp Leu Met Glu Glu Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys           
    365                 370                 375                           

tgc agg aat agc aag aac tcg ctg atc caa atg aca atc ctt aat ttg       1203
Cys Arg Asn Ser Lys Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu           
380                 385                 390                 395           

ttg ccc cgc ttg gct gca ttc cga cct tct gcc ttc aca gat acc cag       1251
Leu Pro Arg Leu Ala Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln           
                400                 405                 410               

tat ctc caa gat acc atg aac cat gtc cta agc tgt gtc aag aag gag       1299
Tyr Leu Gln Asp Thr Met Asn His Val Leu Ser Cys Val Lys Lys Glu           
            415                 420                 425                   

aag gaa cgt aca gcg gcc ttc caa gcc ctg ggg cta ctt tct gtg gct       1347
Lys Glu Arg Thr Ala Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala           
        430                 435                 440                       

gtg agg tct gag ttt aag gtc tat ttg cct cgc gtg ctg gac atc atc       1395
Val Arg Ser Glu Phe Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile           
    445                 450                 455                           

cga gcg gcc ctg ccc cca aag gac ttc gcc cat aag agg cag aag gca       1443
Arg Ala Ala Leu Pro Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala           
460                 465                 470                 475           

atg cag gtg gac gcc aca gtc ttc act tgc atc agc atg ctg gct cga       1491
Met Gln Val Asp Ala Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg           
                480                 485                 490               

gca atg ggg cca ggc atc cag cag gat atc aag gag ctg ctg gag ccc       1539
Ala Met Gly Pro Gly Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro           
            495                 500                 505                   

atg ctg gca gtg gga cta agc cct gcc ctc act gca gtg ctc tac gac       1587
Met Leu Ala Val Gly Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp           
        510                 515                 520                       

ctg agc cgt cag att cca cag cta aag aag gac att caa gat ggg cta       1635
Leu Ser Arg Gln Ile Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu           
    525                 530                 535                           

ctg aaa atg ctg tcc ctg gtc ctt atg cac aaa ccc ctt cgc cac cca       1683
Leu Lys Met Leu Ser Leu Val Leu Met His Lys Pro Leu Arg His Pro           
540                 545                 550                 555           

ggc atg ccc aag ggc ctg gcc cat cag ctg gcc tct cct ggc ctc acg       1731
Gly Met Pro Lys Gly Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr           
                560                 565                 570               

acc ctc cct gag gcc agc gat gtg ggc agc atc act ctt gcc ctc cga       1779
Thr Leu Pro Glu Ala Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg           
            575                 580                 585                   

acg ctt ggc agc ttt gaa ttt gaa ggc cac tct ctg acc caa ttt gtt       1827
Thr Leu Gly Ser Phe Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val           
        590                 595                 600                       

cgc cac tgt gcg gat cat ttt ctg aac agt gag cac aag gag atc cgc       1875
Arg His Cys Ala Asp His Phe Leu Asn Ser Glu His Lys Glu Ile Arg           
    605                 610                 615                           

atg gag gct gcc cgc acc tgc tcc cgc ctg ctc aca ccc tcc atc cac       1923
Met Glu Ala Ala Arg Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His           
620                 625                 630                 635           

ctc atc agt ggc cat gct cat gtg gtt agc cag acc gca gtg caa gtg       1971
Leu Ile Ser Gly His Ala His Val Val Ser Gln Thr Ala Val Gln Val           
                640                 645                 650               

gtg gca gat gtg ctt agc aaa ctg ctc gta gtt ggg ata aca gat cct       2019
Val Ala Asp Val Leu Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro           
            655                 660                 665                   

gac cct gac att cgc tac tgt gtc ttg gcg tcc ctg gac gag cgc ttt       2067
Asp Pro Asp Ile Arg Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe           
        670                 675                 680                       

gat gca cac ctg gcc cag gcg gag aac ttg cag gcc ttg ttt gtg gct       2115
Asp Ala His Leu Ala Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala           
    685                 690                 695                           

ctg aat gac cag gtg ttt gag atc cgg gag ctg gcc atc tgc act gtg       2163
Leu Asn Asp Gln Val Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val           
700                 705                 710                 715           

ggc cga ctc agt agc atg aac cct gcc ttt gtc atg cct ttc ctg cgc       2211
Gly Arg Leu Ser Ser Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg           
                720                 725                 730               

aag atg ctc atc cag att ttg aca gag ttg gag cac agt ggg att gga       2259
Lys Met Leu Ile Gln Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly           
            735                 740                 745                   

aga atc aaa gag cag agt gcc cgc atg ctg ggg cac ctg gtc tcc aat       2307
Arg Ile Lys Glu Gln Ser Ala Arg Met Leu Gly His Leu Val Ser Asn           
        750                 755                 760                       

gcc ccc cga ctc atc cgc ccc tac atg gag cct att ctg aag gca tta       2355
Ala Pro Arg Leu Ile Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu           
    765                 770                 775                           

att ttg aaa ctg aaa gat cca gac cct gat cca aac cca ggt gtg atc       2403
Ile Leu Lys Leu Lys Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile           
780                 785                 790                 795           

aat aat gtc ctg gca aca ata gga gaa ttg gca cag gtt agt ggc ctg       2451
Asn Asn Val Leu Ala Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu           
                800                 805                 810               

gaa atg agg aaa tgg gtt gat gaa ctt ttt att atc atc atg gac atg       2499
Glu Met Arg Lys Trp Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met           
            815                 820                 825                   

ctc cag gat tcc tct ttg ttg gcc aaa agg cag gtg gct ctg tgg acc       2547
Leu Gln Asp Ser Ser Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr           
        830                 835                 840                       

ctg gga cag ttg gtg gcc agc act ggc tat gta gta gag ccc tac agg       2595
Leu Gly Gln Leu Val Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg           
    845                 850                 855                           

aag tac cct act ttg ctt gag gtg cta ctg aat ttt ctg aag act gag       2643
Lys Tyr Pro Thr Leu Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu           
860                 865                 870                 875           

cag aac cag ggt aca cgc aga gag gcc atc cgt gtg tta ggg ctt tta       2691
Gln Asn Gln Gly Thr Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu           
                880                 885                 890               

ggg gct ttg gat cct tac aag cac aaa gtg aac att ggc atg ata gac       2739
Gly Ala Leu Asp Pro Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp           
            895                 900                 905                   

cag tcc cgg gat gcc tct gct gtc agc ctg tca gaa tcc aag tca agt       2787
Gln Ser Arg Asp Ala Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser           
        910                 915                 920                       

cag gat tcc tct gac tat agc act agt gaa atg ctg gtc aac atg gga       2835
Gln Asp Ser Ser Asp Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly           
    925                 930                 935                           

aac ttg cct ctg gat gag ttc tac cca gct gtg tcc atg gtg gcc ctg       2883
Asn Leu Pro Leu Asp Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu           
940                 945                 950                 955           

atg cgg atc ttc cga gac cag tca ctc tct cat cat cac acc atg gtt       2931
Met Arg Ile Phe Arg Asp Gln Ser Leu Ser His His His Thr Met Val           
                960                 965                 970               

gtc cag gcc atc acc ttc atc ttc aag tcc ctg gga ctc aaa tgt gtg       2979
Val Gln Ala Ile Thr Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val           
            975                 980                 985                   

cag ttc ctg ccc cag gtc atg ccc acg ttc ctt aat gtc  att cga gtc      3027
Gln Phe Leu Pro Gln Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val          
        990                 995                 1000                      

tgt gat  ggg gcc atc cgg gaa  ttt ttg ttc cag cag  ctg gga atg        3072
Cys Asp  Gly Ala Ile Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met            
    1005                 1010                 1015                        

ttg gtg  tcc ttt gtg aag agc  cac atc aga cct tat  atg gat gaa        3117
Leu Val  Ser Phe Val Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu            
    1020                 1025                 1030                        

ata gtc  acc ctc atg aga gaa  ttc tgg gtc atg aac  acc tca att        3162
Ile Val  Thr Leu Met Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile            
    1035                 1040                 1045                        

cag agc  acg atc att ctt ctc  att gag caa att gtg  gta gct ctt        3207
Gln Ser  Thr Ile Ile Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu            
    1050                 1055                 1060                        

ggg ggt  gaa ttt aag ctc tac  ctg ccc cag ctg atc  cca cac atg        3252
Gly Gly  Glu Phe Lys Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met            
    1065                 1070                 1075                        

ctg cgt  gtc ttc atg cat gac  aac agc cca ggc cgc  att gtc tct        3297
Leu Arg  Val Phe Met His Asp  Asn Ser Pro Gly Arg  Ile Val Ser            
    1080                 1085                 1090                        

atc aag  tta ctg gct gca atc  cag ctg ttt ggc gcc  aac ctg gat        3342
Ile Lys  Leu Leu Ala Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp            
    1095                 1100                 1105                        

gac tac  ctg cat tta ctg ctg  cct cct att gtt aag  ttg ttt gat        3387
Asp Tyr  Leu His Leu Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp            
    1110                 1115                 1120                        

gcc cct  gaa gct cca ctg cca  tct cga aag gca gcg  cta gag act        3432
Ala Pro  Glu Ala Pro Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr            
    1125                 1130                 1135                        

gtg gac  cgc ctg acg gag tcc  ctg gat ttc act gac  tat gcc tcc        3477
Val Asp  Arg Leu Thr Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser            
    1140                 1145                 1150                        

cgg atc  att cac cct att gtt  cga aca ctg gac cag  agc cca gaa        3522
Arg Ile  Ile His Pro Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu            
    1155                 1160                 1165                        

ctg cgc  tcc aca gcc atg gac  acg ctg tct tca ctt  gtt ttt cag        3567
Leu Arg  Ser Thr Ala Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln            
    1170                 1175                 1180                        

ctg ggg  aag aag tac caa att  ttc att cca atg gtg  aat aaa gtt        3612
Leu Gly  Lys Lys Tyr Gln Ile  Phe Ile Pro Met Val  Asn Lys Val            
    1185                 1190                 1195                        

ctg gtg  cga cac cga atc aat  cat cag cgc tat gat  gtg ctc atc        3657
Leu Val  Arg His Arg Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile            
    1200                 1205                 1210                        

tgc aga  att gtc aag gga tac  aca ctt gct gat gaa  gag gag gat        3702
Cys Arg  Ile Val Lys Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp            
    1215                 1220                 1225                        

cct ttg  att tac cag cat cgg  atg ctt agg agt ggc  caa ggg gat        3747
Pro Leu  Ile Tyr Gln His Arg  Met Leu Arg Ser Gly  Gln Gly Asp            
    1230                 1235                 1240                        

gca ttg  gct agt gga cca gtg  gaa aca gga ccc atg  aag aaa ctg        3792
Ala Leu  Ala Ser Gly Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu            
    1245                 1250                 1255                        

cac gtc  agc acc atc aac ctc  caa aag gcc tgg ggc  gct gcc agg        3837
His Val  Ser Thr Ile Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg            
    1260                 1265                 1270                        

agg gtc  tcc aaa gat gac tgg  ctg gaa tgg ctg aga  cgg ctg agc        3882
Arg Val  Ser Lys Asp Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser            
    1275                 1280                 1285                        

ctg gag  ctg ctg aag gac tca  tca tcg ccc tcc ctg  cgc tcc tgc        3927
Leu Glu  Leu Leu Lys Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys            
    1290                 1295                 1300                        

tgg gcc  ctg gca cag gcc tac  aac ccg atg gcc agg  gat ctc ttc        3972
Trp Ala  Leu Ala Gln Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe            
    1305                 1310                 1315                        

aat gct  gca ttt gtg tcc tgc  tgg tct gaa ctg aat  gaa gat caa        4017
Asn Ala  Ala Phe Val Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln            
    1320                 1325                 1330                        

cag gat  gag ctc atc aga agc  atc gag ttg gcc ctc  acc tca caa        4062
Gln Asp  Glu Leu Ile Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln            
    1335                 1340                 1345                        

gac atc  gct gaa gtc aca cag  acc ctc tta aac ttg  gct gaa ttc        4107
Asp Ile  Ala Glu Val Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe            
    1350                 1355                 1360                        

atg gaa  cac agt gac aag ggc  ccc ctg cca ctg aga  gat gac aat        4152
Met Glu  His Ser Asp Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn            
    1365                 1370                 1375                        

ggc att  gtt ctg ctg ggt gag  aga gct gcc aag tgc  cga gca tat        4197
Gly Ile  Val Leu Leu Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr            
    1380                 1385                 1390                        

gcc aaa  gca cta cac tac aaa  gaa ctg gag ttc cag  aaa ggc ccc        4242
Ala Lys  Ala Leu His Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro            
    1395                 1400                 1405                        

acc cct  gcc att cta gaa tct  ctc atc agc att aat  aat aag cta        4287
Thr Pro  Ala Ile Leu Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu            
    1410                 1415                 1420                        

cag cag  ccg gag gca gcg gcc  gga gtg tta gaa tat  gcc atg aaa        4332
Gln Gln  Pro Glu Ala Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys            
    1425                 1430                 1435                        

cac ttt  gga gag ctg gag atc  cag gct acc tgg tat  gag aaa ctg        4377
His Phe  Gly Glu Leu Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu            
    1440                 1445                 1450                        

cac gag  tgg gag gat gcc ctt  gtg gcc tat gac aag  aaa atg gac        4422
His Glu  Trp Glu Asp Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp            
    1455                 1460                 1465                        

acc aac  aag gac gac cca gag  ctg atg ctg ggc cgc  atg cgc tgc        4467
Thr Asn  Lys Asp Asp Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys            
    1470                 1475                 1480                        

ctc gag  gcc ttg ggg gaa tgg  ggt caa ctc cac cag  cag tgc tgt        4512
Leu Glu  Ala Leu Gly Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys            
    1485                 1490                 1495                        

gaa aag  tgg acc ctg gtt aat  gat gag acc caa gcc  aag atg gcc        4557
Glu Lys  Trp Thr Leu Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala            
    1500                 1505                 1510                        

cgg atg  gct gct gca gct gca  tgg ggt tta ggt cag  tgg gac agc        4602
Arg Met  Ala Ala Ala Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser            
    1515                 1520                 1525                        

atg gaa  gaa tac acc tgt atg  atc cct cgg gac acc  cat gat ggg        4647
Met Glu  Glu Tyr Thr Cys Met  Ile Pro Arg Asp Thr  His Asp Gly            
    1530                 1535                 1540                        

gca ttt  tat aga gct gtg ctg  gca ctg cat cag gac  ctc ttc tcc        4692
Ala Phe  Tyr Arg Ala Val Leu  Ala Leu His Gln Asp  Leu Phe Ser            
    1545                 1550                 1555                        

ttg gca  caa cag tgc att gac  aag gcc agg gac ctg  ctg gat gct        4737
Leu Ala  Gln Gln Cys Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala            
    1560                 1565                 1570                        

gaa tta  act gcg atg gca gga  gag agt tac agt cgg  gca tat ggg        4782
Glu Leu  Thr Ala Met Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly            
    1575                 1580                 1585                        

gcc atg  gtt tct tgc cac atg  ctg tcc gag ctg gag  gag gtt atc        4827
Ala Met  Val Ser Cys His Met  Leu Ser Glu Leu Glu  Glu Val Ile            
    1590                 1595                 1600                        

cag tac  aaa ctt gtc ccc gag  cga cga gag atc atc  cgc cag atc        4872
Gln Tyr  Lys Leu Val Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile            
    1605                 1610                 1615                        

tgg tgg  gag aga ctg cag ggc  tgc cag cgt atc gta  gag gac tgg        4917
Trp Trp  Glu Arg Leu Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp            
    1620                 1625                 1630                        

cag aaa  atc ctt atg gtg cgg  tcc ctt gtg gtc agc  cct cat gaa        4962
Gln Lys  Ile Leu Met Val Arg  Ser Leu Val Val Ser  Pro His Glu            
    1635                 1640                 1645                        

gac atg  aga acc tgg ctc aag  tat gca agc ctg tgc  ggc aag agt        5007
Asp Met  Arg Thr Trp Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser            
    1650                 1655                 1660                        

ggc agg  ctg gct ctt gct cat  aaa act tta gtg ttg  ctc ctg gga        5052
Gly Arg  Leu Ala Leu Ala His  Lys Thr Leu Val Leu  Leu Leu Gly            
    1665                 1670                 1675                        

gtt gat  ccg tct cgg caa ctt  gac cat cct ctg cca  aca gtt cac        5097
Val Asp  Pro Ser Arg Gln Leu  Asp His Pro Leu Pro  Thr Val His            
    1680                 1685                 1690                        

cct cag  gtg acc tat gcc tac  atg aaa aac atg tgg  aag agt gcc        5142
Pro Gln  Val Thr Tyr Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala            
    1695                 1700                 1705                        

cgc aag  atc gat gcc ttc cag  cac atg cag cat ttt  gtc cag acc        5187
Arg Lys  Ile Asp Ala Phe Gln  His Met Gln His Phe  Val Gln Thr            
    1710                 1715                 1720                        

atg cag  caa cag gcc cag cat  gcc atc gct act gag  gac cag cag        5232
Met Gln  Gln Gln Ala Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln            
    1725                 1730                 1735                        

cat aag  cag gaa ctg cac aag  ctc atg gcc cga tgc  ttc ctg aaa        5277
His Lys  Gln Glu Leu His Lys  Leu Met Ala Arg Cys  Phe Leu Lys            
    1740                 1745                 1750                        

ctt gga  gag tgg cag ctg aat  cta cag ggc atc aat  gag agc aca        5322
Leu Gly  Glu Trp Gln Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr            
    1755                 1760                 1765                        

atc ccc  aaa gtg ctg cag tac  tac agc gcc gcc aca  gag cac gac        5367
Ile Pro  Lys Val Leu Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp            
    1770                 1775                 1780                        

cgc agc  tgg tac aag gcc tgg  cat gcg tgg gca gtg  atg aac ttc        5412
Arg Ser  Trp Tyr Lys Ala Trp  His Ala Trp Ala Val  Met Asn Phe            
    1785                 1790                 1795                        

gaa gct  gtg cta cac tac aaa  cat cag aac caa gcc  cgc gat gag        5457
Glu Ala  Val Leu His Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu            
    1800                 1805                 1810                        

aag aag  aaa ctg cgt cat gcc  agc ggg gcc aac atc  acc aac gcc        5502
Lys Lys  Lys Leu Arg His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala            
    1815                 1820                 1825                        

acc act  gcc gcc acc acg gcc  gcc act gcc acc acc  act gcc agc        5547
Thr Thr  Ala Ala Thr Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser            
    1830                 1835                 1840                        

acc gag  ggc agc aac agt gag  agt gag gcc gag agc  acc gag aac        5592
Thr Glu  Gly Ser Asn Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn            
    1845                 1850                 1855                        

agc ccc  acc cca tcg ccg ctg  cag aag aag gtc act  gag gat ctg        5637
Ser Pro  Thr Pro Ser Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu            
    1860                 1865                 1870                        

tcc aaa  acc ctc ctg atg tac  acg gtg cct gcc gtc  cag ggc ttc        5682
Ser Lys  Thr Leu Leu Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe            
    1875                 1880                 1885                        

ttc cgt  tcc atc tcc ttg tca  cga ggc aac aac ctc  cag gat aca        5727
Phe Arg  Ser Ile Ser Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr            
    1890                 1895                 1900                        

ctc aga  gtt ctc acc tta tgg  ttt gat tat ggt cac  tgg cca gat        5772
Leu Arg  Val Leu Thr Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp            
    1905                 1910                 1915                        

gtc aat  gag gcc tta gtg gag  ggg gtg aaa gcc atc  cag att gat        5817
Val Asn  Glu Ala Leu Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp            
    1920                 1925                 1930                        

acc tgg  cta cag gtt ata cct  cag ctc att gca aga  att gat acg        5862
Thr Trp  Leu Gln Val Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr            
    1935                 1940                 1945                        

ccc aga  ccc ttg gtg gga cgt  ctc att cac cag ctt  ctc aca gac        5907
Pro Arg  Pro Leu Val Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp            
    1950                 1955                 1960                        

att ggt  cgg tac cac ccc cag  gcc ctc atc tac cca  ctg aca gtg        5952
Ile Gly  Arg Tyr His Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val            
    1965                 1970                 1975                        

gct tct  aag tct acc acg aca  gcc cgg cac aat gca  gcc aac aag        5997
Ala Ser  Lys Ser Thr Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys            
    1980                 1985                 1990                        

att ctg  aag aac atg tgt gag  cac agc aac acc ctg  gtc cag cag        6042
Ile Leu  Lys Asn Met Cys Glu  His Ser Asn Thr Leu  Val Gln Gln            
    1995                 2000                 2005                        

gcc atg  atg gtg agc gag gag  ctg atc cga gtg gcc  atc ctc tgg        6087
Ala Met  Met Val Ser Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp            
    2010                 2015                 2020                        

cat gag  atg tgg cat gaa ggc  ctg gaa gag gca tct  cgt ttg tac        6132
His Glu  Met Trp His Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr            
    2025                 2030                 2035                        

ttt ggg  gaa agg aac gtg aaa  ggc atg ttt gag gtg  ctg gag ccc        6177
Phe Gly  Glu Arg Asn Val Lys  Gly Met Phe Glu Val  Leu Glu Pro            
    2040                 2045                 2050                        

ttg cat  gct atg atg gaa cgg  ggc ccc cag act ctg  aag gaa aca        6222
Leu His  Ala Met Met Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr            
    2055                 2060                 2065                        

tcc ttt  aat cag gcc tat ggt  cga gat tta atg gag  gcc caa gag        6267
Ser Phe  Asn Gln Ala Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu            
    2070                 2075                 2080                        

tgg tgc  agg aag tac atg aaa  tca ggg aat gtc aag  gac ctc acc        6312
Trp Cys  Arg Lys Tyr Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr            
    2085                 2090                 2095                        

caa gcc  tgg gac ctc tat tat  cat gtg ttc cga cga  atc tca aag        6357
Gln Ala  Trp Asp Leu Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys            
    2100                 2105                 2110                        

cag ctg  cct cag ctc aca tcc  tta gag ctg caa tat  gtt tcc cca        6402
Gln Leu  Pro Gln Leu Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro            
    2115                 2120                 2125                        

aaa ctt  ctg atg tgc cgg gac  ctt gaa ttg gct gtg  cca gga aca        6447
Lys Leu  Leu Met Cys Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr            
    2130                 2135                 2140                        

tat gac  ccc aac cag cca atc  att cgc att cag tcc  ata gca ccg        6492
Tyr Asp  Pro Asn Gln Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro            
    2145                 2150                 2155                        

tct ttg  caa gtc atc aca tcc  aag cag agg ccc cgg  aaa ttg aca        6537
Ser Leu  Gln Val Ile Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr            
    2160                 2165                 2170                        

ctt atg  ggc agc aac gga cat  gag ttt gtt ttc ctt  cta aaa ggc        6582
Leu Met  Gly Ser Asn Gly His  Glu Phe Val Phe Leu  Leu Lys Gly            
    2175                 2180                 2185                        

cat gaa  gat ctg cgc cag gat  gag cgt gtg atg cag  ctc ttc ggc        6627
His Glu  Asp Leu Arg Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly            
    2190                 2195                 2200                        

ctg gtt  aac acc ctc ctg gcc  aat gac cca aca tct  ctt cgg aaa        6672
Leu Val  Asn Thr Leu Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys            
    2205                 2210                 2215                        

aac ctc  agc atc cag aga tac  gct gtc atc cct tta  tcg acc aac        6717
Asn Leu  Ser Ile Gln Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn            
    2220                 2225                 2230                        

tcg ggc  ctc att ggc tgg gtt  ccc cac tgt gac aca  ctg cac gcc        6762
Ser Gly  Leu Ile Gly Trp Val  Pro His Cys Asp Thr  Leu His Ala            
    2235                 2240                 2245                        

ctc atc  cgg gac tac agg gag  aag aag aag atc ctt  ctc aac atc        6807
Leu Ile  Arg Asp Tyr Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile            
    2250                 2255                 2260                        

gag cat  cgc atc atg ttg cgg  atg gct ccg gac tat  gac cac ttg        6852
Glu His  Arg Ile Met Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu            
    2265                 2270                 2275                        

act ctg  atg cag aag gtg gag  gtg ttt gag cat gcc  gtc aat aat        6897
Thr Leu  Met Gln Lys Val Glu  Val Phe Glu His Ala  Val Asn Asn            
    2280                 2285                 2290                        

aca gct  ggg gac gac ctg gcc  aag ctg cta tgg ctg  aaa agc ccc        6942
Thr Ala  Gly Asp Asp Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro            
    2295                 2300                 2305                        

agc tcc  gag gtg tgg ttt gac  cga aga acc aat tat  acc cgt tct        6987
Ser Ser  Glu Val Trp Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser            
    2310                 2315                 2320                        

tta gcg  gtc atg tca atg gtt  ggg tat att tta ggc  ctg gga gat        7032
Leu Ala  Val Met Ser Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp            
    2325                 2330                 2335                        

aga cac  cca tcc aac ctg atg  ctg gac cgt ctg agt  ggg aag atc        7077
Arg His  Pro Ser Asn Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile            
    2340                 2345                 2350                        

ctg cac  att gac ttt ggg gac  tgc ttt gag gtt gct  atg acc cga        7122
Leu His  Ile Asp Phe Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg            
    2355                 2360                 2365                        

gag aag  ttt cca gag aag att  cca ttt aga cta aca  aga atg ttg        7167
Glu Lys  Phe Pro Glu Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu            
    2370                 2375                 2380                        

acc aat  gct atg gag gtt aca  ggc ctg gat ggc aac  tac aga atc        7212
Thr Asn  Ala Met Glu Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile            
    2385                 2390                 2395                        

aca tgc  cac aca gtg atg gag  gtg ctg cga gag cac  aag gac agt        7257
Thr Cys  His Thr Val Met Glu  Val Leu Arg Glu His  Lys Asp Ser            
    2400                 2405                 2410                        

gtc atg  gcc gtg ctg gaa gcc  ttt gtc tat gac ccc  ttg ctg aac        7302
Val Met  Ala Val Leu Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn            
    2415                 2420                 2425                        

tgg agg  ctg atg gac aca aat  acc aaa ggc aac aag  cga tcc cga        7347
Trp Arg  Leu Met Asp Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg            
    2430                 2435                 2440                        

acg agg  acg gat tcc tac tct  gct ggc cag tca gtc  gaa att ttg        7392
Thr Arg  Thr Asp Ser Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu            
    2445                 2450                 2455                        

gac ggt  gtg gaa ctt gga gag  cca gcc cat aag aaa  acg ggg acc        7437
Asp Gly  Val Glu Leu Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr            
    2460                 2465                 2470                        

aca gtg  cca gaa tct att cat  tct ttc att gga gac  ggt ttg gtg        7482
Thr Val  Pro Glu Ser Ile His  Ser Phe Ile Gly Asp  Gly Leu Val            
    2475                 2480                 2485                        

aaa cca  gag gcc cta aat aag  aaa gct atc cag att  att aac agg        7527
Lys Pro  Glu Ala Leu Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg            
    2490                 2495                 2500                        

gtt cga  gat aag ctc act ggt  cgg gac ttc tct cat  gat gac act        7572
Val Arg  Asp Lys Leu Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr            
    2505                 2510                 2515                        

ttg gat  gtt cca acg caa gtt  gag ctg ctc atc aaa  caa gcg aca        7617
Leu Asp  Val Pro Thr Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr            
    2520                 2525                 2530                        

tcc cat  gaa aac ctc tgc cag  tgc tat att ggc tgg  tgc cct ttc        7662
Ser His  Glu Asn Leu Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe            
    2535                 2540                 2545                        

tgg taa ctggaggccc agatgtgccc atcacgtttt ttctgaggct tttgtacttt        7718
Trp                                                                       
                                                                          

agtaaatgct tccactaaac tgaaaccatg gtgagaaagt ttgactttgt taaatatttt     7778

gaaatgtaaa tgaaaagaac tactgtatat taaaagttgg tttgaaccaa ctttctagct     7838

gctgttgaag aatatattgt cagaaacaca aggcttgatt tggttcccag gacagtgaaa     7898

catagtaata ccacgtaaat caagccattc attttgggga acagaagatc cataacttta     7958

gaaatacggg ttttgactta actcacaaga gaactcatca taagtacttg ctgatggaag     8018

aatgacctag ttgctcctct caacatgggt acagcaaact cagcacagcc aagaagcctc     8078

aggtcgtgga gaacatggat taggatccta gactgtaaag acacagaaga tgctgacctc     8138

acccctgcca cctatcc                                                    8155


<210>  6
<211>  2549
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210>  7
<211>  3376
<212>  DNA
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  CDS
<222>  (78)..(1574)

<400>  7
cgcaccgggg atcctaggct ttttggattg cgctttcctc tagatcaact gggtgtcagg       60

ccctatccta cagaagg atg ggt cag att gtg aca atg ttt gag gct ctg         110
                   Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu            
                   1               5                   10                 

cct cac atc atc gat gag gtg atc aac att gtc att att gtg ctt atc        158
Pro His Ile Ile Asp Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile           
            15                  20                  25                    

gtg atc acg ggt atc aag gct gtc tac aat ttt gcc acc tgt ggg ata        206
Val Ile Thr Gly Ile Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile           
        30                  35                  40                        

ttc gca ttg atc agt ttc cta ctt ctg gct ggc agg tcc tgt ggc atg        254
Phe Ala Leu Ile Ser Phe Leu Leu Leu Ala Gly Arg Ser Cys Gly Met           
    45                  50                  55                            

tac ggt ctt aag gga ccc gac att tac aaa gga gtt tac caa ttt aag        302
Tyr Gly Leu Lys Gly Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys           
60                  65                  70                  75            

tca gtg gag ttt gat atg tca cat ctg aac ctg acc atg ccc aac gca        350
Ser Val Glu Phe Asp Met Ser His Leu Asn Leu Thr Met Pro Asn Ala           
                80                  85                  90                

tgt tca gcc aac aac tcc cac cat tac atc agt atg ggg act tct gga        398
Cys Ser Ala Asn Asn Ser His His Tyr Ile Ser Met Gly Thr Ser Gly           
            95                  100                 105                   

cta gaa ttg acc ttc acc aat gat tcc atc atc agt cac aac ttt tgc        446
Leu Glu Leu Thr Phe Thr Asn Asp Ser Ile Ile Ser His Asn Phe Cys           
        110                 115                 120                       

aat ctg acc tct gcc ttc aac aaa aag acc ttt gac cac aca ctc atg        494
Asn Leu Thr Ser Ala Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met           
    125                 130                 135                           

agt ata gtt tcg agc cta cac ctc agt atc aga ggg aac tcc aac tat        542
Ser Ile Val Ser Ser Leu His Leu Ser Ile Arg Gly Asn Ser Asn Tyr           
140                 145                 150                 155           

aag gca gta tcc tgc gac ttc aac aat ggc ata acc atc caa tac aac        590
Lys Ala Val Ser Cys Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn           
                160                 165                 170               

ttg aca ttc tca gat cga caa agt gct cag agc cag tgt aga acc ttc        638
Leu Thr Phe Ser Asp Arg Gln Ser Ala Gln Ser Gln Cys Arg Thr Phe           
            175                 180                 185                   

aga ggt aga gtc cta gat atg ttt aga act gcc ttc ggg ggg aaa tac        686
Arg Gly Arg Val Leu Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr           
        190                 195                 200                       

atg agg agt ggc tgg ggc tgg aca ggc tca gat ggc aag acc acc tgg        734
Met Arg Ser Gly Trp Gly Trp Thr Gly Ser Asp Gly Lys Thr Thr Trp           
    205                 210                 215                           

tgt agc cag acg agt tac caa tac ctg att ata caa aat aga acc tgg        782
Cys Ser Gln Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp           
220                 225                 230                 235           

gaa aac cac tgc aca tat gca ggt cct ttt ggg atg tcc agg att ctc        830
Glu Asn His Cys Thr Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu           
                240                 245                 250               

ctt tcc caa gag aag act aag ttc ttc act agg aga cta gcg ggc aca        878
Leu Ser Gln Glu Lys Thr Lys Phe Phe Thr Arg Arg Leu Ala Gly Thr           
            255                 260                 265                   

ttc acc tgg act ttg tca gac tct tca ggg gtg gag aat cca ggt ggt        926
Phe Thr Trp Thr Leu Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly           
        270                 275                 280                       

tat tgc ctg acc aaa tgg atg att ctt gct gca gag ctt aag tgt ttc        974
Tyr Cys Leu Thr Lys Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe           
    285                 290                 295                           

ggg aac aca gca gtt gcg aaa tgc aat gta aat cat gat gcc gaa ttc       1022
Gly Asn Thr Ala Val Ala Lys Cys Asn Val Asn His Asp Ala Glu Phe           
300                 305                 310                 315           

tgt gac atg ctg cga cta att gac tac aac aag gct gct ttg agt aag       1070
Cys Asp Met Leu Arg Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys           
                320                 325                 330               

ttc aaa gag gac gta gaa tct gcc ttg cac tta ttc aaa aca aca gtg       1118
Phe Lys Glu Asp Val Glu Ser Ala Leu His Leu Phe Lys Thr Thr Val           
            335                 340                 345                   

aat tct ttg att tca gat caa cta ctg atg agg aac cac ttg aga gat       1166
Asn Ser Leu Ile Ser Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp           
        350                 355                 360                       

ctg atg ggg gtg cca tat tgc aat tac tca aag ttt tgg tac cta gaa       1214
Leu Met Gly Val Pro Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu           
    365                 370                 375                           

cat gca aag acc ggc gaa act agt gtc ccc aag tgc tgg ctt gtc acc       1262
His Ala Lys Thr Gly Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr           
380                 385                 390                 395           

aat ggt tct tac tta aat gag acc cac ttc agt gat caa atc gaa cag       1310
Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln           
                400                 405                 410               

gaa gcc gat aac atg att aca gag atg ttg agg aag gat tac ata aag       1358
Glu Ala Asp Asn Met Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys           
            415                 420                 425                   

agg cag ggg agt acc ccc cta gca ttg atg gac ctt ctg atg ttt tcc       1406
Arg Gln Gly Ser Thr Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser           
        430                 435                 440                       

aca tct gca tat cta gtc agc atc ttc ctg cac ctt gtc aaa ata cca       1454
Thr Ser Ala Tyr Leu Val Ser Ile Phe Leu His Leu Val Lys Ile Pro           
    445                 450                 455                           

aca cac agg cac ata aaa ggt ggc tca tgt cca aag cca cac cga tta       1502
Thr His Arg His Ile Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu           
460                 465                 470                 475           

acc aac aaa gga att tgt agt tgt ggt gca ttt aag gtg cct ggt gta       1550
Thr Asn Lys Gly Ile Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val           
                480                 485                 490               

aaa acc gtc tgg aaa aga cgc tga agaacagcgc ctccctgact ctccacctcg      1604
Lys Thr Val Trp Lys Arg Arg                                               
            495                                                           

aaagaggtgg agagtcaggg aggcccagag ggtcttagag tgtcacaaca tttgggcctc     1664

taaaaattag gtcatgtggc agaatgttgt gaacagtttt cagatctggg agccttgctt     1724

tggaggcgct ttcaaaaatg atgcagtcca tgagtgcaca gtgcggggtg atctctttct     1784

tctttttgtc ccttactatt ccagtatgca tcttacacaa ccagccatat ttgtcccaca     1844

ctttgtcttc atactccctc gaagcttccc tggtcatttc aacatcgata agcttaatgt     1904

ccttcctatt ctgtgagtcc agaagctttc tgatgtcatc ggagccttga cagcttagaa     1964

ccatcccctg cggaagagca cctataactg acgaggtcaa cccgggttgc gcattgaaga     2024

ggtcggcaag atccatgccg tgtgagtact tggaatcttg cttgaattgt ttttgatcaa     2084

cgggttccct gtaaaagtgt atgaactgcc cgttctgtgg ttggaaaatt gctatttcca     2144

ctggatcatt aaatctaccc tcaatgtcaa tccatgtagg agcgttgggg tcaattcctc     2204

ccatgaggtc ttttaaaagc attgtctggc tgtagcttaa gcccacctga ggtggacctg     2264

ctgctccagg cgctggcctg ggtgaattga ctgcaggttt ctcgcttgtg agatcaattg     2324

ttgtgttttc ccatgctctc cccacaatcg atgttctaca agctatgtat ggccatcctt     2384

cacctgaaag gcaaacttta tagaggatgt tttcataagg gttcctgtcc ccaacttggt     2444

ctgaaacaaa catgttgagt tttctcttgg ccccgagaac tgccttcaag aggtcctcgc     2504

tgttgcttgg cttgatcaaa attgactcta acatgttacc cccatccaac agggctgccc     2564

ctgccttcac ggcagcacca agactaaagt tatagccaga aatgttgatg ctggactgct     2624

gttcagtgat gacccccaga actgggtgct tgtctttcag cctttcaaga tcattaagat     2684

ttggatactt gactgtgtaa agcaagccaa ggtctgtgag cgcttgtaca acgtcattga     2744

gcggagtctg tgactgtttg gccatacaag ccatagttag acttggcatt gtgccaaatt     2804

gattgttcaa aagtgatgag tctttcacat cccaaactct taccacacca cttgcaccct     2864

gctgaggctt tctcatccca actatctgta ggatctgaga tctttggtct agttgctgtg     2924

ttgttaagtt ccccatatat acccctgaag cctggggcct ttcagacctc atgatcttgg     2984

ccttcagctt ctcaaggtca gccgcaagag acatcagttc ttctgcactg agcctcccca     3044

ctttcaaaac attcttcttt gatgttgact ttaaatccac aagagaatgt acagtctggt     3104

tgagacttct gagtctctgt aggtctttgt catctctctt ttccttcctc atgatcctct     3164

gaacattgct gacctcagag aagtccaacc cattcagaag gttggttgca tccttaatga     3224

cagcagcctt cacatctgat gtgaagctct gcaattctct tctcaatgct tgcgtccatt     3284

ggaagctctt aacttcctta gacaaggaca tcttgttgct caatggtttc tcaagacaaa     3344

tgcgcaatca aatgcctagg atccactgtg cg                                   3376


<210>  8
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus

<400>  8

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Val Ile Thr Gly Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Phe Ala Leu Ile Ser 
        35                  40                  45              


Phe Leu Leu Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Lys Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Thr Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Ile Ser His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn Tyr Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Thr Phe Ser Asp 
                165                 170                 175     


Arg Gln Ser Ala Gln Ser Gln Cys Arg Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Thr Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Thr 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Leu Ser Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Phe Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Ala Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Glu Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Leu Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Val Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Val Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Lys Ala Val Tyr Asn Phe Ala Thr Met 
1               5                   


<210>  10
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
ccgggccaga atccatccat tcattctcga gaatgaatgg atggattctg gctttttg         58


<210>  11
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
aattcaaaaa gccagaatcc atccattcat tctcgagaat gaatggatgg attctggc         58


<210>  12
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
ccgggcccga gtctgtgaat gtaatctcga gattacattc acagactcgg gctttttg         58


<210>  13
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
aattcaaaaa gcccgagtct gtgaatgtaa tctcgagatt acattcacag actcgggc         58


<210>  14
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
ccgggccaaa ctgataatct cctcactcga gtgaggagat tatcagtttg gctttttg         58


<210>  15
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
aattcaaaaa gccaaactga taatctcctc actcgagtga ggagattatc agtttggc         58


<210>  16
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
ccgggcatgg aacattgtga gaaatctcga gatttctcac aatgttccat gctttttg         58


<210>  17
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
aattcaaaaa gcatggaaca ttgtgagaaa tctcgagatt tctcacaatg ttccatgc         58


<210>  18
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
ccggccgaag atagtgattg gttatctcga gataaccaat cactatcttc ggtttttg         58


<210>  19
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
aattcaaaaa ccgaagatag tgattggtta tctcgagata accaatcact atcttcgg         58


