                         SEQUENCE LISTING

<110>  THE GOVERNMENT OF  THE UNITED STATES OF AMERICA AS 
       REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND 
       HUMAN SERVICES
       BERKOWER, Ira
 
<120>  MEMBRANE PROXIMAL REGION OF HIV GP41 ANCHORED TO THE LIPID LAYER 
       OF A VIRUS-LIKE PARTICLE VACCINE

<130>  4239-81675-02

<150>  61/086,098
<151>  2008-08-04

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Asn Glu Xaa Xaa Leu Leu Xaa Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Xaa 
            20                  25              


<210>  2
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  2

Asn Glu Gln Glu Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  3
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  3

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  4
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  4

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  5
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  5

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Arg 
            20                  25              


<210>  6
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  6

Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  7
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  7

Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  8
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  8

Asn Glu Gln Asp Leu Leu Ala Leu Asp Ser Trp Glu Asn Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  9

Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Ser Ile Thr Gln Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  10
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  10

Asn Glu Gln Glu Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  11
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  11

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Asp Asn Leu Trp Ser 
1               5                   10                  15      


Trp Phe Thr Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  12
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  12

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  13
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  13

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Ser Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  14
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  14

Asn Glu Lys Asp Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  15
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  15

Asn Glu Gln Glu Ile Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  16
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  16

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asn Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  17
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  17

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser 
1               5                   10                  15      


Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  18
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  18

Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Ser 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  19
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  19

Asn Glu Gln Glu Leu Leu Gln Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Ser Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  20
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  20

Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  21
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  21

Asn Glu Gln Glu Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg 
            20                  25              


<210>  22
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  22

Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  25              


<210>  23
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  23

Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile 
            20                  25          


<210>  24
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  24

Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg 
            20                  25              


<210>  25
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Ala, Ilu, Leu, Val, Phe, Tyr, Trp, Met or Pro.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be Ala, Ilu, Leu, Val, Phe, Tyr, Trp, Met or Pro.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa can be Ala, Ilu, Leu, Val, Phe, Tyr, Trp, Met or Pro.

<400>  25

Xaa Phe Ile Met Ile Val Gly Gly Leu Xaa Gly Leu Arg Ile Val Phe 
1               5                   10                  15      


Thr Xaa Leu Ser Ile Val 
            20          


<210>  26
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  26

Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
1               5                   10                  15      


Thr Val Leu Ser Ile Val 
            20          


<210>  27
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  27

Leu Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
1               5                   10                  15      


Thr Ala Leu Ser Ile Val 
            20          


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  28

Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe 
1               5                   10                  15      


Thr Ala Leu Ser Ile Val 
            20          


<210>  29
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  29

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Asn Ser Glu Phe Asn Glu Lys Glu 
            20                  25                  30          


Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
        35                  40                  45              


Thr Asn Trp Leu Trp Tyr Ile Arg Leu Phe Ile Met Ile Val Gly Gly 
    50                  55                  60                  


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Pro Gln Ser 
65                  70                  75                  80  


Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val 
                85                  90                  95      


Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr 
            100                 105                 110         


Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg 
        115                 120                 125             


Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 
    130                 135                 140                 


Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro 
145                 150                 155                 160 


Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro 
                165                 170                 175     


Ala Gln Gly Asn Ser Lys Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr 
            180                 185                 190         


Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala 
        195                 200                 205             


Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu 
    210                 215                 220                 


Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp 
225                 230                 235                 240 


Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser 
                245                 250                 255     


Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp 
            260                 265                 270         


Val Tyr Ile Gly 
        275     


<210>  30
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  30

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Asn Ser 
            20                  25      


<210>  31
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  31

Glu Phe Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala 
1               5                   10                  15      


Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp 
            20                  25                  30          


Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys Leu 
        35                  40                  45              


Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys 
    50                  55                  60                  


Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile 
65                  70                  75                  80  


Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 
                85                  90                  95      


Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser 
            100                 105                 110         


Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln 
        115                 120                 125             


Gly Asn Ser Lys Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly 
    130                 135                 140                 


Asn Cys Thr Cys Ile Ser Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr 
145                 150                 155                 160 


Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val 
                165                 170                 175     


Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser 
            180                 185                 190         


Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val 
        195                 200                 205             


Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr 
    210                 215                 220                 


Ile Gly 
225     


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  32

Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ala 
1               5                   10                  15      


Asn Asp 
        


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  33

Ile Lys Leu Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg 
1               5                   10                  15  


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Cys Ala Ala Xaa 
1               


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  35

Glu Leu Asp Lys Trp Ala Ser 
1               5           


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  36

Asn Trp Phe Asp Ile Thr 
1               5       


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  37

Gly Pro Gly Pro 
1               


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  38
ggagctcgtc gacagcaa                                                     18


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  39
gctctagacc cgatgtacac cca                                               23


<210>  40
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  40
gctctagaaa cgagcaggag ctgctg                                            26


<210>  41
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  41
cgcggatcct caccccttga tgtaccacag ccactt                                 36


<210>  42
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  42
cgcggatcct caatggtgat ggtgatggtg ggg                                    33


<210>  43
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  43
gctctagagc cgtggagcgg tacctg                                            26


<210>  44
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  44
ctcggatcct caaatcatga tgaaaatctt gat                                    33


<210>  45
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  45
ctcggatcct cacaccaggc caccaacaat                                        30


<210>  46
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  46
ctcggatcct cacaccagcc tcaggcccac                                        30


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  47
ctcggatcct caggcgggcg c                                                 21


<210>  48
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  48
ccctgcaaga cctgcaccac caccggtcag ggcaactcca agttcccc                    48


<210>  49
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  49
ggggaacttg gagttgccct gaccggtggt ggtgcaggtc ttgcaggg                    48


<210>  50
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  50
ggcaccggta acgagcagga gctgctg                                           27


<210>  51
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  51
ggcaccggtc cccttgatgt accacagcca ctt                                    33


<210>  52
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  52
agcgaattca acgagcagga gctgctg                                           27


<210>  53
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  53
cgcggatcct cacccgatgt acaccca                                           27


<210>  54
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  54
caggaagccg gaggtgatga accccttgat gtaccacagc cactt                       45


<210>  55
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer.

<400>  55
aagtggctgt ggtacatcaa ggggttcatc acctccggct tcctg                       45


<210>  56
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  56

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Asn Ser Glu Phe Ile Thr Ser Gly 
            20                  25                  30          


Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 
        35                  40                  45              


Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu 
    50                  55                  60                  


Asn Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser 
65                  70                  75                  80  


Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly 
                85                  90                  95      


Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu 
            100                 105                 110         


Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 
        115                 120                 125             


Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly 
    130                 135                 140                 


Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Lys Phe Pro 
145                 150                 155                 160 


Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Ser 
                165                 170                 175     


Ile Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
            180                 185                 190         


Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Ser Ser Leu Trp Ala Ile 
        195                 200                 205             


Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu 
    210                 215                 220                 


Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp 
225                 230                 235                 240 


Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser 
                245                 250                 255     


Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp 
            260                 265                 270         


Val Tyr Ile Gly 
        275     


<210>  57
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  57

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Asn Ser Glu Phe Ile Thr Ser Gly 
            20                  25                  30          


Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 
        35                  40                  45              


Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu 
    50                  55                  60                  


Asn Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser 
65                  70                  75                  80  


Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly 
                85                  90                  95      


Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu 
            100                 105                 110         


Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 
        115                 120                 125             


Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly 
    130                 135                 140                 


Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Lys Phe Pro 
145                 150                 155                 160 


Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Asn 
                165                 170                 175     


Ile Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
            180                 185                 190         


Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg Leu Phe Ile 
        195                 200                 205             


Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu 
    210                 215                 220                 


Ser Ile Val Val Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp 
225                 230                 235                 240 


Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe 
                245                 250                 255     


Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile Gly 
            260                 265                 270     


<210>  58
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  58

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Asn Ser Glu Phe Asn Glu Lys Glu 
            20                  25                  30          


Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
        35                  40                  45              


Thr Asn Trp Leu Trp Tyr Ile Arg Leu Phe Ile Met Ile Val Gly Gly 
    50                  55                  60                  


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Pro Gln Ser 
65                  70                  75                  80  


Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val 
                85                  90                  95      


Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr 
            100                 105                 110         


Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg 
        115                 120                 125             


Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 
    130                 135                 140                 


Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro 
145                 150                 155                 160 


Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro 
                165                 170                 175     


Ala Gln Gly Asn Ser Lys Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr 
            180                 185                 190         


Asp Gly Asn Cys Thr Cys Ile Pro Ile Asn Glu Lys Glu Leu Leu Glu 
        195                 200                 205             


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp 
    210                 215                 220                 


Leu Trp Tyr Ile Arg Leu Phe Ile Met Ile Val Gly Gly Leu Ile Gly 
225                 230                 235                 240 


Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Val Gly Leu Ser Pro 
                245                 250                 255     


Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser 
            260                 265                 270         


Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe 
        275                 280                 285             


Cys Leu Trp Val Tyr Ile Gly 
    290                 295 


<210>  59
<211>  1730
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced nuceic acid sequence.

<400>  59
ggtaccgtcg acagcaaaag caggggataa ttctattaac catgaagact atcattgctt       60

ccatggcagc tgtcgttttc gtcccctatt aagataattg gtacttctga tagtaacgaa      120

tgagctacat tttctgtctg gttttcgccc aagaccttcc aggaaatgac aacaacagcg      180

actcgatgta aaagacagac caaaagcggg ttctggaagg tcctttactg ttgttgtcgc      240

aattcatcac ctccggcttc ctgggccccc tgctggtcct gcaggccggg ttcttcctgc      300

ttaagtagtg gaggccgaag gacccggggg acgaccagga cgtccggccc aagaaggacg      360

tgacccgcat cctcaccatc ccccagtccc tggactcgtg gtggacctcc ctcaactttc      420

actgggcgta ggagtggtag ggggtcaggg acctgagcac cacctggagg gagttgaaag      480

tggggggctc ccccgtgtgt ctgggccaga actcccagtc ccccacctcc aaccactccc      540

accccccgag ggggcacaca gacccggtct tgagggtcag ggggtggagg ttggtgaggg      600

ccacctcctg cccccccatc tgccccggct accgctggat gtgcctgcgc cgcttcatca      660

ggtggaggac gggggggtag acggggccga tggcgaccta cacggacgcg gcgaagtagt      720

tcttcctgtt catcctgctg ctgtgcctga tcttcctgct ggtgctgctg gactaccagg      780

agaaggacaa gtaggacgac gacacggact agaaggacga ccacgacgac ctgatggtcc      840

gcatgctgcc cgtgtgcccc ctgatccccg gctccaccac cacctccacc ggcccctgca      900

cgtacgacgg gcacacgggg gactaggggc cgaggtggtg gtggaggtgg ccggggacgt      960

agacctgcac cacccccgcc cagggcaact ccaagttccc ctcctgctgc tgcaccaagc     1020

tctggacgtg gtgggggcgg gtcccgttga ggttcaaggg gaggacgacg acgtggttcg     1080

ccaccgacgg caactgcacc tgcatcaata ttaatgaaaa agaattattg gaattggata     1140

ggtggctgcc gttgacgtgg acgtagttat aattactttt tcttaataac cttaacctat     1200

aatgggcaag tttgtggaat tggtttgaca taacaaactg gctgtggtat ataagattat     1260

ttacccgttc aaacacctta accaaactgt attgtttgac cgacaccata tattctaata     1320

tcataatgat agtaggaggc ttgataggtt taagaatagt ttttgctgta ctttctatag     1380

agtattacta tcatcctccg aactatccaa attcttatca aaaacgacat gaaagatatc     1440

tagtgggcct gtcccccacc gtgtggctgt ccgccatctg gatgatgtgg tactggggcc     1500

atcacccgga cagggggtgg cacaccgaca ggcggtagac ctactacacc atgaccccgg     1560

cctccctgta ctccatcgtg tcccccttca tccccctgct gcccatcttc ttctgcctgt     1620

ggagggacat gaggtagcac agggggaagt agggggacga cgggtagaag aagacggaca     1680

gggtgtacat ctgactagtg agctccccac atgtagactg atcactcgag                1730


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  60

Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
1               5                   10                  15  


<210>  61
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  61

Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp 
            20                  25  


<210>  62
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  62

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Asn Ser Glu Phe Asn Glu Lys Glu 
            20                  25                  30          


Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
        35                  40                  45              


Thr Asn Trp Leu Trp Tyr Ile Arg Leu Phe Ile Met Ile Val Gly Gly 
    50                  55                  60                  


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Pro Gln Ser 
65                  70                  75                  80  


Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val 
                85                  90                  95      


Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr 
            100                 105                 110         


Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg 
        115                 120                 125             


Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 
    130                 135                 140                 


Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro 
145                 150                 155                 160 


Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro 
                165                 170                 175     


Ala Gln Gly Asn Ser Lys Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr 
            180                 185                 190         


Asp Gly Asn Cys Thr Cys Ile Ser Ile Asn Glu Lys Glu Leu Leu Glu 
        195                 200                 205             


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp 
    210                 215                 220                 


Leu Trp Ser Ser Leu Trp Ala Ile Lys Tyr Leu Trp Glu Trp Ala Ser 
225                 230                 235                 240 


Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe 
                245                 250                 255     


Val Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp 
            260                 265                 270         


Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu 
        275                 280                 285             


Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile Gly 
    290                 295                 300 


<210>  63
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  63

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Asn Ser Glu Phe Ile Thr Ser Gly 
            20                  25                  30          


Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 
        35                  40                  45              


Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu 
    50                  55                  60                  


Asn Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser 
65                  70                  75                  80  


Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly 
                85                  90                  95      


Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu 
            100                 105                 110         


Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 
        115                 120                 125             


Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly 
    130                 135                 140                 


Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Lys Phe Pro 
145                 150                 155                 160 


Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Ser 
                165                 170                 175     


Ile Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
            180                 185                 190         


Ala Ile Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 
        195                 200                 205             


Trp Ala Ile Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 
    210                 215                 220                 


Leu Trp Ala Ile Asn Glu Lys Glu Leu Leu Glu Leu Asp Lys Trp Ala 
225                 230                 235                 240 


Ser Leu Trp Ala Ile Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe 
                245                 250                 255     


Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu 
            260                 265                 270         


Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly 
        275                 280                 285             


Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile 
    290                 295                 300                 


Phe Phe Cys Leu Trp Val Tyr Ile Gly 
305                 310             


<210>  64
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly produced peptide.

<400>  64

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Asn Ser Glu Phe Asn Glu Lys Glu 
            20                  25                  30          


Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
        35                  40                  45              


Thr Asn Trp Leu Trp Tyr Ile Arg Leu Phe Ile Met Ile Val Gly Gly 
    50                  55                  60                  


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Pro Gln Ser 
65                  70                  75                  80  


Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val 
                85                  90                  95      


Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr 
            100                 105                 110         


Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg 
        115                 120                 125             


Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 
    130                 135                 140                 


Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro 
145                 150                 155                 160 


Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro 
                165                 170                 175     


Ala Gln Gly Asn Ser Lys Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr 
            180                 185                 190         


Asp Gly Asn Cys Thr Cys Ile Ser Ile Asn Glu Lys Glu Leu Leu Glu 
        195                 200                 205             


Leu Asp Lys Trp Ala Ser Leu Trp Ala Ile Asn Glu Lys Glu Leu Leu 
    210                 215                 220                 


Glu Leu Asp Lys Trp Ala Ser Leu Trp Ala Ile Asn Glu Lys Glu Leu 
225                 230                 235                 240 


Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Ala Ile Asn Glu Lys Glu 
                245                 250                 255     


Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Ala Ile Lys Tyr Leu 
            260                 265                 270         


Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro 
        275                 280                 285             


Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Ala 
    290                 295                 300                 


Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser 
305                 310                 315                 320 


Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
                325                 330                 335     


Gly 
    


