                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       Represented by the Secretary, Department of Health and Human 
       Services
 
<120>  METHODS FOR INTRACELLULAR MODULATION OF BONE MORPHOGENETIC ROTEIN
        SIGNALING

<130>  NIHA-0430 / E-338-2005/0-PCT-02

<150>  US 61/086,679
<151>  2008-08-06

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1305
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctgcccg cgcgctgcgc ccgcctgctc acgccccact tgctgctggt gttggtgcag       60

ctgtcccctg ctcgcggcca ccgcaccaca ggccccaggt ttctaataag tgaccgtgac      120

ccacagtgca acctccactg ctccaggact caacccaaac ccatctgtgc ctctgatggc      180

aggtcctacg agtccatgtg tgagtaccag cgagccaagt gccgagaccc gaccctgggc      240

gtggtgcatc gaggtagatg caaagatgct ggccagagca agtgtcgcct ggagcgggct      300

caagccctgg agcaagccaa gaagcctcag gaagctgtgt ttgtcccaga gtgtggcgag      360

gatggctcct ttacccaggt gcagtgccat acttacactg ggtactgctg gtgtgtcacc      420

ccggatggga agcccatcag tggctcttct gtgcagaata aaactcctgt atgttcaggt      480

tcagtcaccg acaagccctt gagccagggt aactcaggaa ggaaagatga cgggtctaag      540

ccgacaccca cgatggagac ccagccggtg ttcgatggag atgaaatcac agccccaact      600

ctatggatta aacacttggt gatcaaggac tccaaactga acaacaccaa cataagaaat      660

tcagagaaag tctattcgtg tgaccaggag aggcagagtg ccctggaaga ggcccagcag      720

aatccccgtg agggtattgt catccctgaa tgtgcccctg ggggactcta taagccagtg      780

caatgccacc agtccactgg ctactgctgg tgtgtgctgg tggacacagg gcgcccgctg      840

cctgggacct ccacacgcta cgtgatgccc agttgtgaga gcgacgccag ggccaagact      900

acagaggcgg atgacccctt caaggacagg gagctaccag gctgtccaga agggaagaaa      960

atggagttta tcaccagcct actggatgct ctcaccactg acatggttca ggccattaac     1020

tcagcagcgc ccactggagg tgggaggttc tcagagccag accccagcca caccctggag     1080

gagcgggtag tgcactggta tttcagccag ctggacagca atagcagcaa cgacattaac     1140

aagcgggaga tgaagccctt caagcgctac gtgaagaaga aagccaagcc caagaaatgt     1200

gcccggcgtt tcaccgacta ctgtgacctg aacaaagaca aggtcatttc actgcctgag     1260

ctgaagggct gcctgggtgt tagcaaagaa ggacgcctcg tctaa                     1305


<210>  2
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Pro Ala Arg Cys Ala Arg Leu Leu Thr Pro His Leu Leu Leu 
1               5                   10                  15      


Val Leu Val Gln Leu Ser Pro Ala Arg Gly His Arg Thr Thr Gly Pro 
            20                  25                  30          


Arg Phe Leu Ile Ser Asp Arg Asp Pro Gln Cys Asn Leu His Cys Ser 
        35                  40                  45              


Arg Thr Gln Pro Lys Pro Ile Cys Ala Ser Asp Gly Arg Ser Tyr Glu 
    50                  55                  60                  


Ser Met Cys Glu Tyr Gln Arg Ala Lys Cys Arg Asp Pro Thr Leu Gly 
65                  70                  75                  80  


Val Val His Arg Gly Arg Cys Lys Asp Ala Gly Gln Ser Lys Cys Arg 
                85                  90                  95      


Leu Glu Arg Ala Gln Ala Leu Glu Gln Ala Lys Lys Pro Gln Glu Ala 
            100                 105                 110         


Val Phe Val Pro Glu Cys Gly Glu Asp Gly Ser Phe Thr Gln Val Gln 
        115                 120                 125             


Cys His Thr Tyr Thr Gly Tyr Cys Trp Cys Val Thr Pro Asp Gly Lys 
    130                 135                 140                 


Pro Ile Ser Gly Ser Ser Val Gln Asn Lys Thr Pro Val Cys Ser Gly 
145                 150                 155                 160 


Ser Val Thr Asp Lys Pro Leu Ser Gln Gly Asn Ser Gly Arg Lys Asp 
                165                 170                 175     


Asp Gly Ser Lys Pro Thr Pro Thr Met Glu Thr Gln Pro Val Phe Asp 
            180                 185                 190         


Gly Asp Glu Ile Thr Ala Pro Thr Leu Trp Ile Lys His Leu Val Ile 
        195                 200                 205             


Lys Asp Ser Lys Leu Asn Asn Thr Asn Ile Arg Asn Ser Glu Lys Val 
    210                 215                 220                 


Tyr Ser Cys Asp Gln Glu Arg Gln Ser Ala Leu Glu Glu Ala Gln Gln 
225                 230                 235                 240 


Asn Pro Arg Glu Gly Ile Val Ile Pro Glu Cys Ala Pro Gly Gly Leu 
                245                 250                 255     


Tyr Lys Pro Val Gln Cys His Gln Ser Thr Gly Tyr Cys Trp Cys Val 
            260                 265                 270         


Leu Val Asp Thr Gly Arg Pro Leu Pro Gly Thr Ser Thr Arg Tyr Val 
        275                 280                 285             


Met Pro Ser Cys Glu Ser Asp Ala Arg Ala Lys Thr Thr Glu Ala Asp 
    290                 295                 300                 


Asp Pro Phe Lys Asp Arg Glu Leu Pro Gly Cys Pro Glu Gly Lys Lys 
305                 310                 315                 320 


Met Glu Phe Ile Thr Ser Leu Leu Asp Ala Leu Thr Thr Asp Met Val 
                325                 330                 335     


Gln Ala Ile Asn Ser Ala Ala Pro Thr Gly Gly Gly Arg Phe Ser Glu 
            340                 345                 350         


Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val His Trp Tyr Phe 
        355                 360                 365             


Ser Gln Leu Asp Ser Asn Ser Ser Asn Asp Ile Asn Lys Arg Glu Met 
    370                 375                 380                 


Lys Pro Phe Lys Arg Tyr Val Lys Lys Lys Ala Lys Pro Lys Lys Cys 
385                 390                 395                 400 


Ala Arg Arg Phe Thr Asp Tyr Cys Asp Leu Asn Lys Asp Lys Val Ile 
                405                 410                 415     


Ser Leu Pro Glu Leu Lys Gly Cys Leu Gly Val Ser Lys Glu Gly Arg 
            420                 425                 430         


Leu Val 
        


<210>  3
<211>  1392
<212>  DNA
<213>  Xenopus laevis

<400>  3
atgaccccaa gactagtgat cgcacttttt gtaacttgct actttgtcct tctgcatctg       60

cctcagtgtt tcggccaaag agcgactggc cccaggtttt taataagtga tcgggacaga      120

gaccctcagt gcaatcctca ctgcaccagg ccacaacata aaccagtatg tgcttcagat      180

ggtcggacct atgaatctat gtgcgattat caacgagcca agtgcaagga ctcttccctt      240

agtgtgaccc aacgtggaag gtgcaaagat gctggtcaga gcaagtgtcg tctggaaagg      300

actcaagcgc ttgaacaggc gaagaagccc caggaagctg tgtttatacc tgaatgcaat      360

gaagatggat catttactca agtgcaatgt catacgttca caggatactg ctggtgcgtc      420

acccctgatg gcaaacctgt aagcggctct tcagtgcaga acaaaacacc tgtatgttca      480

ggttctgtaa ctgagaagcc ctcaagtcag ggcaattccg gcaggagagg gggaagaggc      540

cctcacccaa tacttagggg tgaaattcag agttcggatc atccatcgca aaacgtaggg      600

ggtggggtca tagacatcac cgctcctacg ctctggataa agcaccttgt tatcaaagat      660

gccaaactaa acagctcaag cgttaaacac ccagagaagg caaattcctg cgatcaggag      720

cgacaaagtg ctctggagga agccaaactg aacccaagag agggaattgt gattccagaa      780

tgtgccccag gcggccttta caaacctgtg cagtgccacc agtccactgg atattgttgg      840

tgtgtcttag tagacactgg tcgtccattg cctggaacat ctacacgtta tgaaactcct      900

gtgtgcgaaa gtgatgccag atggaaaaat acggacgctg aagacccatt taaagacaga      960

gaattagcag gttgtccaga aggaaagaag ctggaattca tcaccagttt attggacgct     1020

ctcaccacgg acatggtgca agccatcaac tcagcagcgc cggccgcagg cgggagattc     1080

tcagagccag atcccaatca cacactggag gaaagagtgg tcctttggta cttcagccag     1140

ttagacagca acgccagtga ggacataaat aagaaggaga tgaagccctt caaaagatac     1200

gtaaaaaaga aagccaaacc caagaaatgt gcccggcgtt tcactgacta ctgtgatctt     1260

aataaggaca aatccatttc atttccagag cttaaaggct gtctaggagt ccgcaaggaa     1320

ccaggtgcaa atgctggaag tttccctcct ggaaagcggc ccggctctaa ccccttcagt     1380

cgccttgcgt ag                                                         1392


<210>  4
<211>  463
<212>  PRT
<213>  Xenopus laevis

<400>  4

Met Thr Pro Arg Leu Val Ile Ala Leu Phe Val Thr Cys Tyr Phe Val 
1               5                   10                  15      


Leu Leu His Leu Pro Gln Cys Phe Gly Gln Arg Ala Thr Gly Pro Arg 
            20                  25                  30          


Phe Leu Ile Ser Asp Arg Asp Arg Asp Pro Gln Cys Asn Pro His Cys 
        35                  40                  45              


Thr Arg Pro Gln His Lys Pro Val Cys Ala Ser Asp Gly Arg Thr Tyr 
    50                  55                  60                  


Glu Ser Met Cys Asp Tyr Gln Arg Ala Lys Cys Lys Asp Ser Ser Leu 
65                  70                  75                  80  


Ser Val Thr Gln Arg Gly Arg Cys Lys Asp Ala Gly Gln Ser Lys Cys 
                85                  90                  95      


Arg Leu Glu Arg Thr Gln Ala Leu Glu Gln Ala Lys Lys Pro Gln Glu 
            100                 105                 110         


Ala Val Phe Ile Pro Glu Cys Asn Glu Asp Gly Ser Phe Thr Gln Val 
        115                 120                 125             


Gln Cys His Thr Phe Thr Gly Tyr Cys Trp Cys Val Thr Pro Asp Gly 
    130                 135                 140                 


Lys Pro Val Ser Gly Ser Ser Val Gln Asn Lys Thr Pro Val Cys Ser 
145                 150                 155                 160 


Gly Ser Val Thr Glu Lys Pro Ser Ser Gln Gly Asn Ser Gly Arg Arg 
                165                 170                 175     


Gly Gly Arg Gly Pro His Pro Ile Leu Arg Gly Glu Ile Gln Ser Ser 
            180                 185                 190         


Asp His Pro Ser Gln Asn Val Gly Gly Gly Val Ile Asp Ile Thr Ala 
        195                 200                 205             


Pro Thr Leu Trp Ile Lys His Leu Val Ile Lys Asp Ala Lys Leu Asn 
    210                 215                 220                 


Ser Ser Ser Val Lys His Pro Glu Lys Ala Asn Ser Cys Asp Gln Glu 
225                 230                 235                 240 


Arg Gln Ser Ala Leu Glu Glu Ala Lys Leu Asn Pro Arg Glu Gly Ile 
                245                 250                 255     


Val Ile Pro Glu Cys Ala Pro Gly Gly Leu Tyr Lys Pro Val Gln Cys 
            260                 265                 270         


His Gln Ser Thr Gly Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg 
        275                 280                 285             


Pro Leu Pro Gly Thr Ser Thr Arg Tyr Glu Thr Pro Val Cys Glu Ser 
    290                 295                 300                 


Asp Ala Arg Trp Lys Asn Thr Asp Ala Glu Asp Pro Phe Lys Asp Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Cys Pro Glu Gly Lys Lys Leu Glu Phe Ile Thr Ser 
                325                 330                 335     


Leu Leu Asp Ala Leu Thr Thr Asp Met Val Gln Ala Ile Asn Ser Ala 
            340                 345                 350         


Ala Pro Ala Ala Gly Gly Arg Phe Ser Glu Pro Asp Pro Asn His Thr 
        355                 360                 365             


Leu Glu Glu Arg Val Val Leu Trp Tyr Phe Ser Gln Leu Asp Ser Asn 
    370                 375                 380                 


Ala Ser Glu Asp Ile Asn Lys Lys Glu Met Lys Pro Phe Lys Arg Tyr 
385                 390                 395                 400 


Val Lys Lys Lys Ala Lys Pro Lys Lys Cys Ala Arg Arg Phe Thr Asp 
                405                 410                 415     


Tyr Cys Asp Leu Asn Lys Asp Lys Ser Ile Ser Phe Pro Glu Leu Lys 
            420                 425                 430         


Gly Cys Leu Gly Val Arg Lys Glu Pro Gly Ala Asn Ala Gly Ser Phe 
        435                 440                 445             


Pro Pro Gly Lys Arg Pro Gly Ser Asn Pro Phe Ser Arg Leu Ala 
    450                 455                 460             


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
ccacacayyt ggryryrtct ttgca                                             25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
tggargcvct cwccachgac atggt                                             25


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
ccttcataca agtctcacgc ctga                                              24


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
cttcttctgg ccggctctcc ta                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
gttttctgga caagatgccc tt                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
ctccatcaga gcttaatgtc ct                                                22


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
gtcatgttgc ctcttcttat acagg                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
gtgatcttgc gtcttgttat agagg                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
caatcaggcg tgagacttgt atgaa                                             25


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
gagtcgccag agaccgaatg ga                                                22


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
catggcatca tccaccttcc caa                                               23


<210>  16
<211>  435
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (435)..(435)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Met Leu Pro Ala Arg Cys Ala Arg Leu Leu Thr Pro His Leu Leu Leu 
1               5                   10                  15      


Val Leu Val Gln Leu Ser Pro Ala Arg Gly His Arg Thr Thr Gly Pro 
            20                  25                  30          


Arg Phe Leu Ile Ser Asp Arg Asp Pro Gln Cys Asn Leu His Cys Ser 
        35                  40                  45              


Arg Thr Gln Pro Lys Pro Ile Cys Ala Ser Asp Gly Arg Ser Tyr Glu 
    50                  55                  60                  


Ser Met Cys Glu Tyr Gln Arg Ala Lys Cys Arg Asp Pro Thr Leu Gly 
65                  70                  75                  80  


Val Val His Arg Gly Arg Cys Lys Asp Ala Gly Gln Ser Lys Cys Arg 
                85                  90                  95      


Leu Glu Arg Ala Gln Ala Leu Glu Gln Ala Lys Lys Pro Gln Glu Ala 
            100                 105                 110         


Val Phe Val Pro Glu Cys Gly Glu Asp Gly Ser Phe Thr Gln Val Gln 
        115                 120                 125             


Cys His Thr Tyr Thr Gly Tyr Cys Trp Cys Val Thr Pro Asp Gly Lys 
    130                 135                 140                 


Pro Ile Ser Gly Ser Ser Val Gln Asn Lys Thr Pro Val Cys Ser Gly 
145                 150                 155                 160 


Ser Val Thr Asp Lys Pro Leu Ser Gln Gly Asn Ser Gly Arg Lys Asp 
                165                 170                 175     


Asp Gly Ser Lys Pro Thr Pro Thr Met Glu Thr Gln Pro Val Phe Asp 
            180                 185                 190         


Gly Asp Glu Ile Thr Ala Pro Thr Leu Trp Ile Lys His Leu Val Ile 
        195                 200                 205             


Lys Asp Ser Lys Leu Asn Asn Thr Asn Ile Arg Asn Ser Glu Lys Val 
    210                 215                 220                 


Tyr Ser Cys Asp Gln Glu Arg Gln Ser Ala Leu Glu Glu Ala Gln Gln 
225                 230                 235                 240 


Asn Pro Arg Glu Gly Ile Val Ile Pro Glu Cys Ala Pro Gly Gly Leu 
                245                 250                 255     


Tyr Lys Pro Val Gln Cys His Gln Ser Thr Gly Tyr Cys Trp Cys Val 
            260                 265                 270         


Leu Val Asp Thr Gly Arg Pro Leu Pro Gly Thr Ser Thr Arg Tyr Val 
        275                 280                 285             


Met Pro Ser Cys Glu Ser Asp Ala Arg Ala Lys Thr Thr Glu Ala Asp 
    290                 295                 300                 


Asp Pro Phe Lys Asp Arg Glu Leu Pro Gly Cys Pro Glu Gly Lys Lys 
305                 310                 315                 320 


Met Glu Phe Ile Thr Ser Leu Leu Asp Ala Leu Thr Thr Asp Met Val 
                325                 330                 335     


Gln Ala Ile Asn Ser Ala Ala Pro Thr Gly Gly Gly Arg Phe Ser Glu 
            340                 345                 350         


Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val His Trp Tyr Phe 
        355                 360                 365             


Ser Gln Leu Asp Ser Asn Ser Ser Asn Asp Ile Asn Lys Arg Glu Met 
    370                 375                 380                 


Lys Pro Phe Lys Arg Tyr Val Lys Lys Lys Ala Lys Pro Lys Lys Cys 
385                 390                 395                 400 


Ala Arg Arg Phe Thr Asp Tyr Cys Asp Leu Asn Lys Asp Lys Val Ile 
                405                 410                 415     


Ser Leu Pro Glu Leu Lys Gly Cys Leu Gly Val Ser Lys Glu Gly Arg 
            420                 425                 430         


Leu Val Xaa 
        435 


<210>  17
<211>  461
<212>  PRT
<213>  Xenopus

<400>  17

Met Thr Pro Arg Leu Val Ile Ala Leu Phe Val Thr Cys Tyr Phe Val 
1               5                   10                  15      


Leu Leu His Leu Pro Gln Cys Phe Gly Gln Arg Ala Thr Gly Pro Arg 
            20                  25                  30          


Phe Leu Ile Ser Asp Arg Asp Arg Asp Pro Gln Cys Asn Pro His Cys 
        35                  40                  45              


Thr Arg Pro Gln His Lys Pro Val Cys Ala Ser Asp Gly Arg Thr Tyr 
    50                  55                  60                  


Glu Ser Met Cys Asp Tyr Gln Arg Ala Lys Cys Lys Asp Ser Ser Leu 
65                  70                  75                  80  


Ser Val Thr Gln Arg Gly Arg Cys Lys Asp Ala Gly Gln Ser Lys Cys 
                85                  90                  95      


Arg Leu Glu Arg Thr Gln Ala Leu Glu Gln Ala Lys Lys Pro Gln Glu 
            100                 105                 110         


Ala Val Phe Ile Pro Glu Cys Asn Glu Asp Gly Ser Phe Thr Gln Val 
        115                 120                 125             


Gln Cys His Thr Phe Thr Gly Tyr Cys Trp Cys Val Thr Pro Asp Gly 
    130                 135                 140                 


Lys Pro Val Ser Gly Ser Ser Val Gln Asn Lys Thr Pro Val Cys Ser 
145                 150                 155                 160 


Gly Ser Val Thr Glu Lys Pro Ser Ser Gln Gly Asn Ser Gly Arg Arg 
                165                 170                 175     


Gly Arg Arg Gly Pro His Pro Ile Leu Arg Gly Glu Ile Gln Ser Ser 
            180                 185                 190         


Asp His Pro Ser Gln Asn Val Gly Gly Gly Val Ile Asp Ile Thr Ala 
        195                 200                 205             


Pro Thr Leu Trp Ile Lys His Leu Val Ile Lys Asp Ala Lys Leu Asn 
    210                 215                 220                 


Ser Ser Ser Val Lys His Pro Glu Lys Ala Asn Ser Cys Asp Gln Glu 
225                 230                 235                 240 


Arg Gln Ser Ala Leu Glu Glu Ala Lys Leu Asn Pro Arg Glu Gly Ile 
                245                 250                 255     


Val Ile Pro Glu Cys Pro Gly Gly Leu Tyr Lys Pro Val Cys His Gln 
            260                 265                 270         


Ser Thr Gly Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Leu 
        275                 280                 285             


Pro Gly Thr Ser Thr Arg Tyr Glu Thr Pro Val Cys Glu Ser Asp Ala 
    290                 295                 300                 


Arg Trp Lys Asn Thr Asp Ala Glu Asp Pro Phe Lys Asp Arg Glu Leu 
305                 310                 315                 320 


Ala Gly Cys Pro Glu Gly Lys Lys Leu Glu Phe Ile Thr Ser Leu Leu 
                325                 330                 335     


Asp Ala Leu Thr Thr Asp Met Val Gln Ala Ile Asn Ser Ala Ala Pro 
            340                 345                 350         


Ala Ala Gly Gly Arg Phe Ser Glu Pro Asp Pro Asn His Thr Leu Glu 
        355                 360                 365             


Glu Arg Val Val Leu Trp Tyr Phe Ser Gln Leu Asp Ser Asn Ala Ser 
    370                 375                 380                 


Glu Asp Met Asn Lys Lys Glu Met Lys Pro Phe Lys Arg Tyr Val Lys 
385                 390                 395                 400 


Lys Lys Ala Lys Pro Lys Lys Cys Ala Arg Arg Phe Thr Asp Tyr Cys 
                405                 410                 415     


Asp Leu Asn Lys Asp Lys Ser Ile Ser Phe Pro Glu Leu Lys Gly Cys 
            420                 425                 430         


Leu Gly Val Arg Lys Glu Pro Gly Ala Asn Ala Gly Ser Phe Pro Pro 
        435                 440                 445             


Gly Lys Arg Pro Gly Ser Asn Pro Phe Ser Arg Leu Ala 
    450                 455                 460     


<210>  18
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Met Pro Leu Val Leu Leu Gly Arg Thr Gly Pro Arg Phe Leu Ile Ser 
1               5                   10                  15      


Asp Arg Asp Pro Gln Cys Asn His Cys Arg Gln Lys Pro Cys Ala Ser 
            20                  25                  30          


Asp Gly Arg Tyr Glu Ser Met Cys Tyr Gln Arg Ala Lys Cys Asp Leu 
        35                  40                  45              


Val Arg Gly Arg Cys Lys Asp Ala Gly Gln Ser Lys Cys Arg Leu Glu 
    50                  55                  60                  


Arg Gln Ala Leu Glu Gln Ala Lys Lys Pro Gln Glu Ala Val Phe Pro 
65                  70                  75                  80  


Glu Cys Glu Asp Gly Ser Phe Thr Gln Val Gln Cys His Thr Thr Gly 
                85                  90                  95      


Tyr Cys Trp Cys Val Thr Pro Asp Gly Lys Pro Ser Gly Ser Ser Val 
            100                 105                 110         


Gln Asn Lys Thr Pro Val Cys Ser Gly Ser Val Thr Lys Pro Ser Gln 
        115                 120                 125             


Gly Asn Ser Gly Arg Gly Pro Pro Gly Ile Thr Ala Pro Thr Leu Trp 
    130                 135                 140                 


Ile Lys His Leu Val Ile Lys Asp Lys Leu Asn Glu Lys Ser Cys Asp 
145                 150                 155                 160 


Gln Glu Arg Gln Ser Ala Leu Glu Glu Ala Asn Pro Arg Glu Gly Ile 
                165                 170                 175     


Val Ile Pro Glu Cys Gly Lys Pro Val Gln Ser Thr Gly Tyr Cys Trp 
            180                 185                 190         


Cys Val Leu Val Asp Thr Gly Arg Pro Leu Pro Gly Thr Ser Thr Arg 
        195                 200                 205             


Tyr Pro Cys Glu Ser Asp Ala Arg Lys Thr Ala Asp Pro Phe Lys Asp 
    210                 215                 220                 


Arg Glu Leu Gly Cys Pro Glu Gly Lys Lys Glu Phe Ile Thr Ser Leu 
225                 230                 235                 240 


Leu Asp Ala Leu Thr Thr Asp Met Val Gln Ala Ile Asn Ser Ala Ala 
                245                 250                 255     


Pro Gly Gly Arg Phe Ser Glu Pro Asp Pro His Thr Leu Glu Glu Arg 
            260                 265                 270         


Val Val Trp Tyr Phe Ser Gln Leu Asp Ser Asn Ser Asp Asn Lys Glu 
        275                 280                 285             


Met Lys Pro Phe Lys Arg Tyr Val Lys Lys Lys Ala Lys Pro Lys Lys 
    290                 295                 300                 


Cys Ala Arg Arg Phe Thr Asp Tyr Cys Asp Leu Asn Lys Asp Lys Ile 
305                 310                 315                 320 


Ser Pro Glu Leu Lys Gly Cys Leu Gly Val Lys Glu Gly 
                325                 330             


