                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  ANTI-HEPCIDIN-25 SELECTIVE ANTIBODIES AND USES THEREOF

<130>  X18122

<150>  61/086557
<151>  2008-08-06

<160>  90    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      


Ser Lys Cys Gly Met Cys Cys Lys Thr 
            20                  25  


<210>  2
<211>  25
<212>  PRT
<213>  Rattus rattus

<400>  2

Asp Thr Asn Phe Pro Ile Cys Leu Phe Cys Cys Lys Cys Cys Lys Asn 
1               5                   10                  15      


Ser Ser Cys Gly Leu Cys Cys Ile Thr 
            20                  25  


<210>  3
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Thr Asn Phe Pro Ile Cys Ile Phe Cys Cys Lys Cys Cys Asn Asn 
1               5                   10                  15      


Ser Gln Cys Gly Ile Cys Cys Lys Thr 
            20                  25  


<210>  4
<211>  25
<212>  PRT
<213>  macaca sp.

<400>  4

Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      


Ser Lys Cys Gly Met Cys Cys Arg Thr 
            20                  25  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Asp Thr His Phe Pro Ile Cys 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Val or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is Tyr or Ser

<400>  6

Ser Ala Ser Ser Ser Xaa Ser Xaa Met Tyr 
1               5                   10  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Asn or His

<400>  7

Leu Thr Ser Xaa Leu Ala Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Asn, Gly, or Tyr

<400>  8

Gln Gln Trp Ser Ser Xaa Pro Pro Thr 
1               5                   


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Ser Ala Ser Ser Ser Ala Ser Tyr Met Tyr 
1               5                   10  


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Leu Thr Ser His Leu Ala Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gln Gln Trp Ser Ser Gly Pro Pro Thr 
1               5                   


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Ser Ala Ser Ser Ser Val Ser Ser Met Tyr 
1               5                   10  


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is Ser, Arg, or Pro

<400>  17

Lys Ser Ser Gln Ser Leu Leu Tyr Xaa Asn Gly Lys Thr Tyr Leu Thr 
1               5                   10                  15      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is Ser or Pro

<400>  18

Leu Val Ser Lys Leu Asp Xaa 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Val, His, Ile or Phe

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is Thr or Val

<400>  19

Xaa Gln Gly Ser His Phe Pro Trp Xaa 
1               5                   


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu Thr 
1               5                   10                  15      


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Val Gln Gly Ser His Phe Pro Trp Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

His Gln Gly Ser His Phe Pro Trp Thr 
1               5                   


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Lys Ser Ser Gln Ser Leu Leu Tyr Arg Asn Gly Lys Thr Tyr Leu Thr 
1               5                   10                  15      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Leu Val Ser Lys Leu Asp Pro 
1               5           


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Lys Ser Ser Gln Ser Leu Leu Tyr Pro Asn Gly Lys Thr Tyr Leu Thr 
1               5                   10                  15      


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Ile Gln Gly Ser His Phe Pro Trp Thr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Phe Gln Gly Ser His Phe Pro Trp Val 
1               5                   


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Phe, Tyr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 isThr or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is Try or Pro

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is Ile or Phe

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Val or Ile

<400>  29

Gly Xaa Ser Leu Xaa Xaa Xaa Gly Xaa Gly Xaa Gly 
1               5                   10          


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is Ala or Asn

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is Ser or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Ala or Thr

<400>  30

His Ile Trp Trp Asn Xaa Xaa Lys Xaa Tyr Asn Thr Xaa Leu Lys Ser 
1               5                   10                  15      


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Gly or His

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is Ser, Ala or Try

<400>  31

Ile Xaa Tyr Tyr Gly Xaa Xaa Xaa Gly Phe Ala Tyr 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Gly Phe Ser Leu Ser Thr Tyr Gly Ile Gly Val Gly 
1               5                   10          


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

His Ile Trp Trp Asn Asp Asn Lys Ser Tyr Asn Thr Ala Leu Lys Ser 
1               5                   10                  15      


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Ile Gly Tyr Tyr Gly Ser Thr Ser Gly Phe Ala Tyr 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Gly Tyr Ser Leu Ser Thr Pro Gly Ile Gly Val Gly 
1               5                   10          


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

His Ile Trp Trp Asn Asp Ala Lys Ser Tyr Asn Thr Ala Leu Lys Ser 
1               5                   10                  15      


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Ile Gly Tyr Tyr Gly Ser Thr Ala Gly Phe Ala Tyr 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Gly Leu Ser Leu Ser Thr Pro Gly Ile Gly Val Gly 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Gly Phe Ser Leu Asn Ser Tyr Gly Phe Gly Ile Gly 
1               5                   10          


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

His Ile Trp Trp Asn Gly Asn Lys Tyr Tyr Asn Thr Thr Leu Lys Ser 
1               5                   10                  15      


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Ile His Tyr Tyr Gly Asn Ser Tyr Gly Phe Ala Tyr 
1               5                   10          


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Gly Phe Ala Phe Ser Ser Tyr Asp Met Ser 
1               5                   10  


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Thr Ile Ile Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Asp Gly Tyr Ile His 
1               5   


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Ser Ala Ser Pro Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  46
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Asp or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Leu or Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Ser or Pro

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Val or Ala

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Tyr or Ser

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa at position 52 is Asn or His

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa at position 59 is Ala or Pro

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa at position 76 is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa at position 93 is Asn, Tyr or Gly

<400>  46

Xaa Ile Xaa Xaa Xaa Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Xaa Ser Xaa Ser Xaa Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Xaa Leu Ala Ser Gly Val Pro Xaa Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Xaa Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Xaa Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  47
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is Lys or Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Phe, Tyr or Leu

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Tyr or Pro

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa at position 34 is Ile or Phe

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa at position 43 is Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Xaa at position 51 is Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa at position 57 is Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Xaa at position 58 is Asn or Ala

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Xaa at position 60 is Ser or Tyr

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa at position 64 is Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  Xaa at position 87 is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa at position 89 is Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  Xaa at position 90 is His or Asp

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Xaa at position 97 is Val or Ala

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa at position 98 is Leu or Val

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa at position 100 is Gly or His

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa at position 104 is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa at position 105 is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa at position 106 is Ser, Ala or Tyr

<400>  47

Xaa Val Xaa Leu Xaa Xaa Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Xaa Ser Leu Xaa Xaa Xaa 
            20                  25                  30          


Gly Xaa Gly Xaa Gly Trp Ile Arg Gln Pro Xaa Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Xaa His Ile Trp Trp Asn Xaa Xaa Lys Xaa Tyr Asn Thr Xaa 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Xaa Asp Xaa Xaa Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Xaa Xaa Ile Xaa Tyr Tyr Gly Xaa Xaa Xaa Gly Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  48
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Gln Ile Leu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  49
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Ser Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Thr His Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Val Ile Gly Tyr Tyr Gly Ser Thr Ser Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  50
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gln Ile Leu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ala Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser His Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Gly Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  51
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Tyr Ser Leu Ser Thr Pro 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Ala Lys Ser Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Thr His Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Val Ile Gly Tyr Tyr Gly Ser Thr Ala Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  52
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Gln Ile Leu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Pro Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser His Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Gly Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  53
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Gln Ile Leu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ala Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser His Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Gly Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  54
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Leu Ser Leu Ser Thr Pro 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Ala Lys Ser Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Thr His Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Val Ile Gly Tyr Tyr Gly Ser Thr Ala Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  55
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Asp Ile Gln Met Asn Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  56
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Glu Val Lys Leu Val Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Ser Tyr 
            20                  25                  30          


Gly Phe Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Thr His Ile Trp Trp Asn Gly Asn Lys Tyr Tyr Asn Thr Thr 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Ile His Tyr Tyr Gly Asn Ser Tyr Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  57
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Ser, Arg or Pro

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa at position 61 is Ser or Pro

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa at position 94 is Val, His, Ile or Phe

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Xaa at position 102 is Thr or Val

<400>  57

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Xaa 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Xaa Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Xaa Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Xaa Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  58
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ile Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Asp Gly Tyr Ile His Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  59
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  60
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys His Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  61
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Arg 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys His Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  62
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Pro 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Ile Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  63
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Pro 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  64
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Asp or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Leu or Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Ser or Pro

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Val or Ala

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Tyr or Ser

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa at position 52 is Asn or His

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa at position 59 is Ala or Pro

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa at position 76 is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa at position 93 is Asn, Tyr or Gly

<400>  64

Xaa Ile Xaa Xaa Xaa Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Xaa Ser Xaa Ser Xaa Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Xaa Leu Ala Ser Gly Val Pro Xaa Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Xaa Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Xaa Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  65
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is Lys or Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Phe, Tyr or Leu

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Tyr or Pro

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa at position 34 is Ile or Phe

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa at position 43 is Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Xaa at position 51 is Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa at position 57 is Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Xaa at position 58 is Asn or Ala

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Xaa at position 60 is Ser or Tyr

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa at position 64 is Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  Xaa at position 87 is Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa at position 89 is Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  Xaa at position 90 is His or Asp

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Xaa at position 97 is Val or Ala

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa at position 98 is Leu or Val

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa at position 100 is Gly or His

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa at position 104 is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa at position 105 is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa at position 106 is Ser, Ala or Try

<400>  65

Xaa Val Xaa Leu Xaa Xaa Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Xaa Ser Leu Xaa Xaa Xaa 
            20                  25                  30          


Gly Xaa Gly Xaa Gly Trp Ile Arg Gln Pro Xaa Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Xaa His Ile Trp Trp Asn Xaa Xaa Lys Xaa Tyr Asn Thr Xaa 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Xaa Asp Xaa Xaa Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Xaa Xaa Ile Xaa Tyr Tyr Gly Xaa Xaa Xaa Gly Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    290                 295                 300                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            340                 345                 350         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        355                 360                 365             


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    370                 375                 380                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                405                 410                 415     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445 


<210>  66
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Gln Ile Leu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  67
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Ser Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Thr His Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Val Ile Gly Tyr Tyr Gly Ser Thr Ser Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  68
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Gln Ile Leu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ala Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser His Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Gly Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  69
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Tyr Ser Leu Ser Thr Pro 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Ala Lys Ser Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Thr His Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Val Ile Gly Tyr Tyr Gly Ser Thr Ala Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  70
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Gln Ile Leu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Pro Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser His Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Gly Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  71
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Gln Ile Leu Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ala Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser His Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Gly Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  72
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Leu Ser Leu Ser Thr Pro 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Ala Lys Ser Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Thr His Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Val Ile Gly Tyr Tyr Gly Ser Thr Ala Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  73
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73

Asp Ile Gln Met Asn Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  74
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Glu Val Lys Leu Val Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Ser Tyr 
            20                  25                  30          


Gly Phe Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Thr His Ile Trp Trp Asn Gly Asn Lys Tyr Tyr Asn Thr Thr 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Ile His Tyr Tyr Gly Asn Ser Tyr Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  75
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Ser, Arg or Pro

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa at position 61 is Ser or Pro

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa at position 94 is Val, His, Ile or Phe

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Xaa at position 102 is Thr or Val

<400>  75

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Xaa 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Xaa Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Xaa Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Xaa Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  76
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ile Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Asp Gly Tyr Ile His Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             


Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr 
                165                 170                 175     


Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu 
            180                 185                 190         


Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
    210                 215                 220                 


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
            260                 265                 270         


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        275                 280                 285             


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
                325                 330                 335     


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
            340                 345                 350         


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
        355                 360                 365             


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
    370                 375                 380                 


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
385                 390                 395                 400 


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
                405                 410                 415     


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
            420                 425                 430         


Ser His Ser Pro Gly Lys 
        435             


<210>  77
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  78
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys His Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  79
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  79

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Arg 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys His Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  80
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Pro 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Ile Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  81
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81

Asp Ile Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Pro 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Thr Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Phe Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  82
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Pro Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  83
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Leu Ile Tyr 
            20                  25                  30          


Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Leu Gly Val Thr Asn Tyr Val Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  84
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  85
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Leu Ile Tyr 
            20                  25                  30          


Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Leu Gly Val Thr Asn Tyr Leu Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Asp Thr Asn Phe Pro Ile Cys 
1               5           


<210>  87
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87

Asp Thr His Phe Pro Ile Cys Gly Pro Gly Pro Gly Ile Ser Gln Ala 
1               5                   10                  15      


Val His Ala Ala His Ala Glu Ile Asn Glu 
            20                  25      


<210>  88
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  88

Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys Gly Met 
1               5                   10                  15      


Cys Cys Lys Thr 
            20  


<210>  89
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  89

Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys 
1               5                   10                  15      


Gly Met Cys Cys Lys Thr 
            20          


<210>  90
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  90

Gly Ser Val Phe Pro Gln Gln Thr Gly Gln Leu Ala Glu Leu Gln Pro 
1               5                   10                  15      


Gln Asp Arg Ala Gly Ala Arg Ala Ser Trp Met Pro Met Phe Gln Arg 
            20                  25                  30          


Arg Arg Arg Arg Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly 
        35                  40                  45              


Cys Cys His Arg Ser Lys Cys Gly Met Cys Cys Lys Thr 
    50                  55                  60      


