                         SEQUENCE LISTING

<110>  Case Western Reserve University
 
<120>  HALOGEN-STABILIZED INSULIN

<130>  200512.00075

<150>  US 61/085,212
<151>  2008-07-31

<160>  26    

<170>  PatentIn version 3.4

<210>  1
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(26)
<223>  One Phe is halogenated

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Tyr or Phe

<400>  4

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Xaa Thr Pro Lys Thr 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(26)
<223>  One Phe is halogenated

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Tyr or Phe

<400>  5

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Xaa Thr Lys Pro Thr 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(26)
<223>  One Phe is halogenated

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Tyr or Phe

<400>  6

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Xaa Thr Asp Lys Thr 
            20                  25                  30  


<210>  7
<211>  86
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is His or Phe

<220>
<221>  MISC_FEATURE
<222>  (24)..(26)
<223>  One Phe is halogenated

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Pro, Lys or Asp

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lys or Pro

<220>
<221>  VARIANT
<222>  (31)..(65)
<223>  Any 0-35 residues or a break in the amino acid chain may be 
       present.

<220>
<221>  MISC_FEATURE
<222>  (31)..(65)
<223>  Residue at any positions 31-65 may be any amino acid residue; no 
       relative information regarding relative frequency of alternative 
       residues is implied.

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is His or Glu

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  Xaa is His or Thr

<400>  7

Xaa Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Xaa Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Gly Ile Val Xaa Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  8
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(26)
<223>  One Phe is halogenated

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Tyr or Phe

<400>  8

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Xaa Thr Lys Pro Thr 
            20                  25                  30  


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  One Phe is halogenated

<400>  9

Gly Phe Phe Tyr Thr Lys Pro Thr 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  One Phe is halogenated

<400>  10

Gly Phe Phe Tyr Thr Pro Lys Thr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  11

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  12
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  12
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg     60

gaacgaggct agttctacac acccaagacc                                      90


<210>  13
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  13
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt     60

gaaagaggtt agttttacac tccaaagact                                      90


<210>  14
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  14
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg     60

gaacgaggct agttctacac acccaagacc cgccgggagg cagaggacct gcaggtgggg    120

caggtggagc tgggcggcgg ccctggtgca ggcagcctgc agcccttggc cctggagggg    180

tccctgcaga agcgtggcat tgtggaacaa tgctgtacca gcatctgctc cctctaccag    240

ctggagaact actgcaacta g                                              261


<210>  15
<211>  261
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt     60

gaaagaggtt agttttacac tccaaagact agaagagaag ctgaagattt gcaagttggt    120

caagttgaat tgggtggtgg tccaggtgct ggttctttgc aaccattggc tttggaaggt    180

tctttgcaaa agagaggtat tgttgaacaa tgttgtactt ctatttgttc tttgtaccaa    240

ttggaaaact actgtaacta a                                              261


<210>  16
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg 
            20          


<210>  17
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  17

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg 
            20          


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Phe is halogenated

<400>  18

Gly Phe Phe Phe Thr Lys Pro Thr 
1               5               


<210>  19
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  19
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg     60

gaacgaggct tctagtacac acccaagacc                                      90


<210>  20
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  20
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt     60

gaaagaggtt tttagtacac tccaaagact                                      90


<210>  21
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  21
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg     60

gaacgaggct tctagtacac acccaagacc cgccgggagg cagaggacct gcaggtgggg    120

caggtggagc tgggcggcgg ccctggtgca ggcagcctgc agcccttggc cctggagggg    180

tccctgcaga agcgtggcat tgtggaacaa tgctgtacca gcatctgctc cctctaccag    240

ctggagaact actgcaacta g                                              261


<210>  22
<211>  261
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt     60

gaaagaggtt tttagtacac tccaaagact agaagagaag ctgaagattt gcaagttggt    120

caagttgaat tgggtggtgg tccaggtgct ggttctttgc aaccattggc tttggaaggt    180

tctttgcaaa agagaggtat tgttgaacaa tgttgtactt ctatttgttc tttgtaccaa    240

ttggaaaact actgtaacta a                                              261


<210>  23
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  23
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg     60

gaacgaggct tcttctagac acccaagacc                                      90


<210>  24
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt     60

gaaagaggtt ttttttagac tccaaagact                                      90


<210>  25
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  25
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg     60

gaacgaggct tcttctagac acccaagacc cgccgggagg cagaggacct gcaggtgggg    120

caggtggagc tgggcggcgg ccctggtgca ggcagcctgc agcccttggc cctggagggg    180

tccctgcaga agcgtggcat tgtggaacaa tgctgtacca gcatctgctc cctctaccag    240

ctggagaact actgcaacta g                                              261


<210>  26
<211>  261
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  26
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt     60

gaaagaggtt ttttttagac tccaaagact agaagagaag ctgaagattt gcaagttggt    120

caagttgaat tgggtggtgg tccaggtgct ggttctttgc aaccattggc tttggaaggt    180

tctttgcaaa agagaggtat tgttgaacaa tgttgtactt ctatttgttc tttgtaccaa    240

ttggaaaact actgtaacta a                                              261


