                         SEQUENCE LISTING

<110>  CHRISTADOSS, PREMKUMAR
       ALLMAN, WINDY
 
<120>  METHODS AND COMPOSITION RELATED TO ACETYLCHOLINE RECEPTOR 
       CONJUGATES

<130>  UTFG:288WO

<140>  PCT/US2009/052121
<141>  2009-07-29

<150>  61/084,504
<151>  2008-07-29

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gly Asp 
65                  70                  75                  80  


Met Val Asp Leu Pro Arg Pro Ser Cys Val Thr Leu Gly Val Pro Leu 
                85                  90                  95      


Phe Ser His Leu Gln Asn Glu Gln Trp Val Asp Tyr Asn Leu Lys Trp 
            100                 105                 110         


Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu 
        115                 120                 125             


Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly Asp 
    130                 135                 140                 


Phe Ala Ile Val Lys Phe Thr Lys Val Leu Leu Gln Tyr Thr Gly His 
145                 150                 155                 160 


Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile 
                165                 170                 175     


Val Thr His Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly 
            180                 185                 190         


Thr Trp Thr Tyr Asp Gly Ser Val Val Ala Ile Asn Pro Glu Ser Asp 
        195                 200                 205             


Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly Glu Trp Val Ile Lys 
    210                 215                 220                 


Glu Ser Arg Gly Trp Lys His Ser Val Thr Tyr Ser Cys Cys Pro Asp 
225                 230                 235                 240 


Thr Pro Tyr Leu Asp Ile Thr Tyr His Phe Val Met Gln Arg Leu Pro 
                245                 250                 255     


Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys Leu Leu Phe Ser Phe 
            260                 265                 270         


Leu Thr Gly Leu Val Phe Tyr Leu Pro Thr Asp Ser Gly Glu Lys Met 
        275                 280                 285             


Thr Leu Ser Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val 
    290                 295                 300                 


Ile Val Glu Leu Ile Pro Ser Thr Ser Ser Ala Val Pro Leu Ile Gly 
305                 310                 315                 320 


Lys Tyr Met Leu Phe Thr Met Val Phe Val Ile Ala Ser Ile Ile Ile 
                325                 330                 335     


Thr Val Ile Val Ile Asn Thr His His Arg Ser Pro Ser Thr His Val 
            340                 345                 350         


Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp Thr Ile Pro Asn Ile 
        355                 360                 365             


Met Phe Phe Ser Thr Met Lys Arg Pro Ser Arg Glu Lys Gln Asp Lys 
    370                 375                 380                 


Lys Ile Phe Thr Glu Asp Ile Asp Ile Ser Asp Ile Ser Gly Lys Pro 
385                 390                 395                 400 


Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu Ile Lys His Pro Glu 
                405                 410                 415     


Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Thr Met Lys 
            420                 425                 430         


Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu Trp Lys Tyr Val Ala 
        435                 440                 445             


Met Val Met Asp His Ile Leu Leu Gly Val Phe Met Leu Val Cys Ile 
    450                 455                 460                 


Ile Gly Thr Leu Ala Val Phe Ala Gly Arg Leu Ile Glu Leu Asn Gln 
465                 470                 475                 480 


Gln Gly 
        


<210>  2
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gly Asp 
65                  70                  75                  80  


Met Val Asp Leu Pro Arg Pro Ser Cys Val Thr Leu Gly Val Pro Leu 
                85                  90                  95      


Phe Ser His Leu Gln Asn Glu Gln Trp Val Asp Tyr Asn Leu Lys Trp 
            100                 105                 110         


Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu 
        115                 120                 125             


Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly Asp 
    130                 135                 140                 


Phe Ala Ile Val Lys Phe Thr Lys Val Leu Leu Gln Tyr Thr Gly His 
145                 150                 155                 160 


Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile 
                165                 170                 175     


Val Thr His Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly 
            180                 185                 190         


Thr Trp Thr Tyr Asp Gly Ser Val Val Ala Ile Asn Pro Glu Ser Asp 
        195                 200                 205             


Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly Glu Trp Val Ile Lys 
    210                 215                 220                 


Glu Ser Arg Gly Trp Lys His Ser Val Thr Tyr Ser Cys Cys Pro Asp 
225                 230                 235                 240 


Thr Pro Tyr Leu Asp Ile Thr Tyr His Phe Val Met Gln Arg Leu Pro 
                245                 250                 255     


Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys Leu Leu Phe Ser Phe 
            260                 265                 270         


Leu Thr Gly Leu Val Phe Tyr Leu Pro Thr Asp Ser Gly Glu Lys Met 
        275                 280                 285             


Thr Leu Ser Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val 
    290                 295                 300                 


Ile Val Glu Leu Ile Pro Ser Thr Ser Ser Ala Val Pro Leu Ile Gly 
305                 310                 315                 320 


Lys Tyr Met Leu Phe Thr Met Val Phe Val Ile Ala Ser Ile Ile Ile 
                325                 330                 335     


Thr Val Ile Val Ile Asn Thr His His Arg Ser Pro Ser Thr His Val 
            340                 345                 350         


Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp Thr Ile Pro Asn Ile 
        355                 360                 365             


Met Phe Phe Ser Thr Met Lys Arg Pro Ser Arg Glu Lys Gln Asp Lys 
    370                 375                 380                 


Lys Ile Phe Thr Glu Asp Ile Asp Ile Ser Asp Ile Ser Gly Lys Pro 
385                 390                 395                 400 


Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu Ile Lys His Pro Glu 
                405                 410                 415     


Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Thr Met Lys 
            420                 425                 430         


Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu Trp Lys Tyr Val Ala 
        435                 440                 445             


Met Val Met Asp His Ile Leu Leu Gly Val Phe Met Leu Val Cys Ile 
    450                 455                 460                 


Ile Gly Thr Leu Ala Val Phe Ala Gly Arg Leu Ile Glu Leu Asn Gln 
465                 470                 475                 480 


Gln Gly 
        


<210>  3
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gly Asp 
65                  70                  75                  80  


Met Val Asp Leu Pro Arg Pro Ser Cys Val Thr Leu Gly Val Pro Leu 
                85                  90                  95      


Phe Ser His Leu Gln Asn Glu Gln Trp Val Asp Tyr Asn Leu Lys Trp 
            100                 105                 110         


Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu 
        115                 120                 125             


Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly Asp 
    130                 135                 140                 


Phe Ala Ile Val Lys Phe Thr Lys Val Leu Leu Gln Tyr Thr Gly His 
145                 150                 155                 160 


Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile 
                165                 170                 175     


Val Thr His Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly 
            180                 185                 190         


Thr Trp Thr Tyr Asp Gly Ser Val Val Ala Ile Asn Pro Glu Ser Asp 
        195                 200                 205             


Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly Glu Trp Val Ile Lys 
    210                 215                 220                 


Glu Ser Arg Gly Trp Lys His Ser Val Thr Tyr Ser Cys Cys Pro Asp 
225                 230                 235                 240 


Thr Pro Tyr Leu Asp Ile Thr Tyr His Phe Val Met Gln Arg Leu Pro 
                245                 250                 255     


Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys Leu Leu Phe Ser Phe 
            260                 265                 270         


Leu Thr Gly Leu Val Phe Tyr Leu Pro Thr Asp Ser Gly Glu Lys Met 
        275                 280                 285             


Thr Leu Ser Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val 
    290                 295                 300                 


Ile Val Glu Leu Ile Pro Ser Thr Ser Ser Ala Val Pro Leu Ile Gly 
305                 310                 315                 320 


Lys Tyr Met Leu Phe Thr Met Val Phe Val Ile Ala Ser Ile Ile Ile 
                325                 330                 335     


Thr Val Ile Val Ile Asn Thr His His Arg Ser Pro Ser Thr His Val 
            340                 345                 350         


Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp Thr Ile Pro Asn Ile 
        355                 360                 365             


Met Phe Phe Ser Thr Met Lys Arg Pro Ser Arg Glu Lys Gln Asp Lys 
    370                 375                 380                 


Lys Ile Phe Thr Glu Asp Ile Asp Ile Ser Asp Ile Ser Gly Lys Pro 
385                 390                 395                 400 


Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu Ile Lys His Pro Glu 
                405                 410                 415     


Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Thr Met Lys 
            420                 425                 430         


Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu Trp Lys Tyr Val Ala 
        435                 440                 445             


Met Val Met Asp His Ile Leu Leu Gly Val Phe Met Leu Val Cys Ile 
    450                 455                 460                 


Ile Gly Thr Leu Ala Val Phe Ala Gly Arg Leu Ile Glu Leu Asn Gln 
465                 470                 475                 480 


Gln Gly 
        


<210>  4
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Arg Ala Pro Leu Gly Val Leu Leu Leu Leu Gly Leu Leu Gly 
1               5                   10                  15      


Arg Gly Val Gly Lys Asn Glu Glu Leu Arg Leu Tyr His His Leu Phe 
            20                  25                  30          


Asn Asn Tyr Asp Pro Gly Ser Arg Pro Val Arg Glu Pro Glu Asp Thr 
        35                  40                  45              


Val Thr Ile Ser Leu Lys Val Thr Leu Thr Asn Leu Ile Ser Leu Asn 
    50                  55                  60                  


Glu Lys Glu Glu Thr Leu Thr Thr Ser Val Trp Ile Gly Ile Asp Trp 
65                  70                  75                  80  


Gln Asp Tyr Arg Leu Asn Tyr Ser Lys Asp Asp Phe Gly Gly Ile Glu 
                85                  90                  95      


Thr Leu Arg Val Pro Ser Glu Leu Val Trp Leu Pro Glu Ile Val Leu 
            100                 105                 110         


Glu Asn Asn Ile Asp Gly Gln Phe Gly Val Ala Tyr Asp Ala Asn Val 
        115                 120                 125             


Leu Val Tyr Glu Gly Gly Ser Val Thr Trp Leu Pro Pro Ala Ile Tyr 
    130                 135                 140                 


Arg Ser Val Cys Ala Val Glu Val Thr Tyr Phe Pro Phe Asp Trp Gln 
145                 150                 155                 160 


Asn Cys Ser Leu Ile Phe Arg Ser Gln Thr Tyr Asn Ala Glu Glu Val 
                165                 170                 175     


Glu Phe Thr Phe Ala Val Asp Asn Asp Gly Lys Thr Ile Asn Lys Ile 
            180                 185                 190         


Asp Ile Asp Thr Glu Ala Tyr Thr Glu Asn Gly Glu Trp Ala Ile Asp 
        195                 200                 205             


Phe Cys Pro Gly Val Ile Arg Arg His His Gly Gly Ala Thr Asp Gly 
    210                 215                 220                 


Pro Gly Glu Thr Asp Val Ile Tyr Ser Leu Ile Ile Arg Arg Lys Pro 
225                 230                 235                 240 


Leu Phe Tyr Val Ile Asn Ile Ile Val Pro Cys Val Leu Ile Ser Gly 
                245                 250                 255     


Leu Val Leu Leu Ala Tyr Phe Leu Pro Ala Gln Ala Gly Gly Gln Lys 
            260                 265                 270         


Cys Thr Val Ser Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu Phe 
        275                 280                 285             


Leu Ile Ala Gln Lys Ile Pro Glu Thr Ser Leu Ser Val Pro Leu Leu 
    290                 295                 300                 


Gly Arg Phe Leu Ile Phe Val Met Val Val Ala Thr Leu Ile Val Met 
305                 310                 315                 320 


Asn Cys Val Ile Val Leu Asn Val Ser Gln Arg Thr Pro Thr Thr His 
                325                 330                 335     


Ala Met Ser Pro Arg Leu Arg His Val Leu Leu Glu Leu Leu Pro Arg 
            340                 345                 350         


Leu Leu Gly Ser Pro Pro Pro Pro Glu Ala Pro Arg Ala Ala Ser Pro 
        355                 360                 365             


Pro Arg Arg Ala Ser Ser Val Gly Leu Leu Leu Arg Ala Glu Glu Leu 
    370                 375                 380                 


Ile Leu Lys Lys Pro Arg Ser Glu Leu Val Phe Glu Gly Gln Arg His 
385                 390                 395                 400 


Arg Gln Gly Thr Trp Thr Ala Ala Phe Cys Gln Ser Leu Gly Ala Ala 
                405                 410                 415     


Ala Pro Glu Val Arg Cys Cys Val Asp Ala Val Asn Phe Val Ala Glu 
            420                 425                 430         


Ser Thr Arg Asp Gln Glu Ala Thr Gly Glu Glu Val Ser Asp Trp Val 
        435                 440                 445             


Arg Met Gly Asn Ala Leu Asp Asn Ile Cys Phe Trp Ala Ala Leu Val 
    450                 455                 460                 


Leu Phe Ser Val Gly Ser Ser Leu Ile Phe Leu Gly Ala Tyr Phe Asn 
465                 470                 475                 480 


Arg Val Pro Asp Leu Pro Tyr Ala Pro Cys Ile Gln Pro 
                485                 490             


<210>  5
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Thr Asp Thr Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Thr Asn Gly Ser Glu Leu Val Thr Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Thr Thr Asn 
65                  70                  75                  80  


Val Trp Leu Thr Gln Glu Trp Glu Asp Tyr Arg Leu Thr Trp Lys Pro 
                85                  90                  95      


Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile 
            100                 105                 110         


Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu 
        115                 120                 125             


Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe 
    130                 135                 140                 


Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys 
145                 150                 155                 160 


His Phe Pro Phe Asp Gln Gln Asn Cys Thr Met Lys Phe Arg Ser Trp 
                165                 170                 175     


Thr Tyr Asp Arg Thr Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala 
            180                 185                 190         


Ser Leu Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu 
        195                 200                 205             


Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Thr Tyr Val Asp Ile 
    210                 215                 220                 


Thr Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Thr Ile Asn 
225                 230                 235                 240 


Leu Ile Ile Pro Cys Val Leu Ile Thr Ser Leu Ala Ile Leu Val Phe 
                245                 250                 255     


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val 
            260                 265                 270         


Leu Leu Ala Leu Thr Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro 
        275                 280                 285             


Pro Thr Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Thr 
    290                 295                 300                 


Met Val Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn 
305                 310                 315                 320 


Val His His Arg Ser Pro Thr Thr His Thr Met Ala Pro Trp Val Lys 
                325                 330                 335     


Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro 
            340                 345                 350         


Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg 
        355                 360                 365             


Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala 
    370                 375                 380                 


Asp Ser Cys Thr Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala 
385                 390                 395                 400 


Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser 
                405                 410                 415     


Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly Val Arg 
            420                 425                 430         


Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Ser 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Ile Phe Val Phe Val Cys Val Phe Gly Thr Ile Gly Met Phe Leu Gln 
465                 470                 475                 480 


Pro Leu Phe Gln Asn Tyr Thr Thr Thr Thr Phe Leu His Ser Asp His 
                485                 490                 495     


Ser Ala Pro Ser Ser Lys 
            500         


<210>  6
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr Ala 
                165                 170                 175     


Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg Thr 
            180                 185                 190         


Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu Asn 
        195                 200                 205             


Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp Pro 
    210                 215                 220                 


Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Thr Phe Tyr Leu 
225                 230                 235                 240 


Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val Pro 
                245                 250                 255     


Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro Ala 
            260                 265                 270         


Asp Ser Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala Gln 
        275                 280                 285             


Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser Met 
    290                 295                 300                 


Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu Val 
305                 310                 315                 320 


Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe Arg 
                325                 330                 335     


Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Leu Phe Leu 
            340                 345                 350         


Glu Thr Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp Gly 
        355                 360                 365             


Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr Ile 
    370                 375                 380                 


Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu Met 
385                 390                 395                 400 


Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr Thr 
                405                 410                 415     


Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu Phe 
            420                 425                 430         


Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn His 
        435                 440                 445             


Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn Arg 
    450                 455                 460                 


Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro Val 
465                 470                 475                 480 


Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn Gln 
                485                 490                 495     


Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val Gln 
            500                 505                 510         


Asp Lys Arg Phe Ile 
        515         


<210>  7
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  7

Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys 
        115                 120                 125             


Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala 
    130                 135                 140                 


Ile Phe Arg Ser Ala Cys Ser Ile Ser Val Thr Tyr Phe Pro Phe Asp 
145                 150                 155                 160 


Trp Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Thr Tyr Ser Thr Asn 
                165                 170                 175     


Glu Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Thr Ile Glu Trp 
            180                 185                 190         


Ile Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile 
        195                 200                 205             


Gln His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln 
    210                 215                 220                 


Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys 
225                 230                 235                 240 


Pro Leu Phe Tyr Val Ile Asn Ile Ile Ala Pro Cys Val Leu Ile Ser 
                245                 250                 255     


Ser Val Ala Ile Leu Ile His Phe Leu Pro Ala Lys Ala Gly Gly Gln 
            260                 265                 270         


Lys Cys Thr Val Ala Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu 
        275                 280                 285             


Phe Leu Val Ala Lys Lys Val Pro Glu Thr Ser Gln Ala Val Pro Leu 
    290                 295                 300                 


Ile Ser Lys Tyr Leu Thr Phe Leu Leu Val Val Thr Ile Leu Ile Val 
305                 310                 315                 320 


Val Asn Ala Val Val Val Leu Asn Val Ser Leu Arg Ser Pro His Thr 
                325                 330                 335     


His Ser Met Ala Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro 
            340                 345                 350         


Gln Leu Leu Arg Met His Val Arg Pro Leu Ala Pro Ala Ala Val Gln 
        355                 360                 365             


Asp Thr Gln Ser Arg Leu Gln Asn Gly Ser Ser Gly Trp Ser Ile Thr 
    370                 375                 380                 


Thr Gly Glu Glu Val Ala Leu Cys Leu Pro Arg Ser Glu Leu Leu Phe 
385                 390                 395                 400 


Gln Gln Trp Gln Arg Gln Gly Leu Val Ala Ala Ala Leu Glu Lys Leu 
                405                 410                 415     


Glu Lys Gly Pro Glu Leu Gly Leu Ser Gln Phe Cys Gly Ser Leu Lys 
            420                 425                 430         


Gln Ala Ala Pro Ala Ile Gln Ala Cys Val Glu Ala Cys Asn Leu Ile 
        435                 440                 445             


Ala Cys Ala Arg His Gln Gln Ser His Phe Asp Asn Gly Asn Glu Glu 
    450                 455                 460                 


Trp Phe Leu Val Gly Arg Val Leu Asp Arg Val Cys Phe Leu Ala Met 
465                 470                 475                 480 


Leu Ser Leu Phe Ile Cys Gly Thr Ala Gly Ile Phe Leu Met Ala His 
                485                 490                 495     


Tyr Asn Arg Val Pro Ala Leu Pro Phe Pro Gly Asp Pro Arg Pro Tyr 
            500                 505                 510         


Leu Pro Ser Pro Asp 
        515         


