
                                SEQUENCE LISTING

<110> Merck & Co., Inc.

<120> VARIANT  HCMV pp65, IE1, AND IE2
  POLYNUCLEOTIDES AND USES THEREOF
  

<130> MRL-IFD-22555

<150> 61/137,685          
<151> 2008-08-01  

<160> 44

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 561
<212> PRT
<213> human cytomegalovirus

<400> 1
Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly
 1               5                  10                  15      
Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr
            20                  25                  30          
Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val
        35                  40                  45              
Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp
    50                  55                  60                  
Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr
65                  70                  75                  80  
Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Val His Asn
                85                  90                  95      
Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr
            100                 105                 110         
Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val
        115                 120                 125             
His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His Leu Pro Val
    130                 135                 140                 
Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg
145                 150                 155                 160 
Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn Gln Trp Lys
                165                 170                 175     
Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro Thr Lys Asp
            180                 185                 190         
Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val Cys Ser Met
        195                 200                 205             
Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr Val
    210                 215                 220                 
Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser Gly Lys Leu
225                 230                 235                 240 
Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp Leu Thr Met
                245                 250                 255     
Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe
            260                 265                 270         
Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly Lys Ile Ser
        275                 280                 285             
His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu
    290                 295                 300                 
Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly Asn Leu Leu
305                 310                 315                 320 
Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile Arg Glu Thr
                325                 330                 335     
Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp
            340                 345                 350         
Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Pro Thr
        355                 360                 365             
Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr Arg His Thr
    370                 375                 380                 
Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp Asp Val Trp
385                 390                 395                 400 
Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr Glu Arg Lys
                405                 410                 415     
Thr Pro Arg Val Thr Gly Gly Gly Ala Met Ala Gly Ala Ser Thr Ser
            420                 425                 430         
Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser Ala Thr Ala Cys Thr Ser
        435                 440                 445             
Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr Val Ala Pro
    450                 455                 460                 
Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His Asn Pro Ala
465                 470                 475                 480 
Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu
                485                 490                 495     
Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr Gln Glu
            500                 505                 510         
Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu
        515                 520                 525             
Gly Val Trp Gln Pro Ala Ala Gln Pro Lys Arg Arg Arg His Arg Gln
    530                 535                 540                 
Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser Thr Pro Lys Lys His Arg
545                 550                 555                 560 
Gly
    


<210> 2
<211> 1686
<212> DNA
<213> human cytomegalovirus

<400> 2
atggagtcgc gcggtcgccg ttgtcccgaa atgatatccg tactgggtcc catttcgggg 60
cacgtgctga aagccgtgtt tagtcgcggc gatacgccgg tgctgccgca cgagacgcga 120
ctcctgcaga cgggtatcca cgtacgcgtg agccagccct cgctgatctt ggtatcgcag 180
tacacgcccg actcgacgcc atgccaccgc ggcgacaatc agctgcaggt gcagcacacg 240
tactttacgg gcagcgaggt ggagaacgtg tcggtcaacg tgcacaaccc cacgggccga 300
agcatctgcc ccagccagga gcccatgtcg atctatgtgt acgcgctgcc gctcaagatg 360
ctgaacatcc ccagcatcaa cgtgcaccac tacccgtcgg cggccgagcg caaacaccga 420
cacctgcccg tagctgacgc tgtgattcac gcgtcgggca agcagatgtg gcaggcgcgt 480
ctcacggtct cgggactggc ctggacgcgt cagcagaacc agtggaaaga gcccgacgtc 540
tactacacgt cagcgttcgt gtttcccacc aaggacgtgg cactgcggca cgtggtgtgc 600
gcgcacgagc tggtttgctc catggagaac acgcgcgcaa ccaagatgca ggtgataggt 660
gaccagtacg tcaaggtgta cctggagtcc ttctgcgagg acgtgccctc cggcaagctc 720
tttatgcacg tcacgctggg ctctgacgtg gaagaggacc tgacgatgac ccgcaacccg 780
caacccttca tgcgccccca cgagcgcaac ggctttacgg tgttgtgtcc caaaaatatg 840
ataatcaaac cgggcaagat ctcgcacatc atgctggatg tggcttttac ctcacacgag 900
cattttgggc tgctgtgtcc caagagcatc ccgggcctga gcatctcagg taacctgttg 960
atgaacgggc agcagatctt cctggaggta caagccatac gcgagaccgt ggaactgcgt 1020
cagtacgatc ccgtggctgc gctcttcttt ttcgatatcg acttgctgct gcagcgcggg 1080
cctcagtaca gcgagcaccc caccttcacc agccagtatc gcatccaggg caagcttgag 1140
taccgacaca cctgggaccg gcacgacgag ggtgccgccc agggcgacga cgacgtctgg 1200
accagcggat cggactccga cgaagaactc gtaaccaccg agcgcaagac gccccgcgtc 1260
accggcggcg gcgccatggc gggcgcctcc acttccgcgg gccgcaaacg caaatcagca 1320
tcctcggcga cggcgtgcac gtcgggcgtt atgacacgcg gccgccttaa ggccgagtcc 1380
accgtcgcgc ccgaagagga caccgacgag gattccgaca acgaaatcca caatccggcc 1440
gtgttcacct ggccgccctg gcaggccggc atcctggccc gcaacctggt gcccatggtg 1500
gctacggttc agggtcagaa tctgaagtac caggaattct tctgggacgc caacgacatc 1560
taccgcatct tcgccgaatt ggaaggcgta tggcagcccg ctgcgcaacc caaacgtcgc 1620
cgccaccggc aagacgcctt gcccgggcca tgcatcgcct cgacgcccaa aaagcaccga 1680
ggttga                                                            1686

<210> 3
<211> 535
<212> PRT
<213> Artificial Sequence

<220> 
<223> protein variant of HCMV pp65 (mpp65)

<400> 3
Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly
 1               5                  10                  15      
Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr
            20                  25                  30          
Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val
        35                  40                  45              
Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp
    50                  55                  60                  
Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr
65                  70                  75                  80  
Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Val His Asn
                85                  90                  95      
Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr
            100                 105                 110         
Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val
        115                 120                 125             
His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His Leu Pro Val
    130                 135                 140                 
Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg
145                 150                 155                 160 
Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn Gln Trp Lys
                165                 170                 175     
Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro Thr Lys Asp
            180                 185                 190         
Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val Cys Ser Met
        195                 200                 205             
Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr Val
    210                 215                 220                 
Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser Gly Lys Leu
225                 230                 235                 240 
Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp Leu Thr Met
                245                 250                 255     
Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe
            260                 265                 270         
Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly Lys Ile Ser
        275                 280                 285             
His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu
    290                 295                 300                 
Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly Asn Leu Leu
305                 310                 315                 320 
Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile Arg Glu Thr
                325                 330                 335     
Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp
            340                 345                 350         
Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Pro Thr
        355                 360                 365             
Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr Arg His Thr
    370                 375                 380                 
Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp Asp Val Trp
385                 390                 395                 400 
Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr Glu Gly Gly
                405                 410                 415     
Thr Pro Gly Val Thr Gly Gly Gly Ala Met Ala Gly Ala Ser Thr Ser
            420                 425                 430         
Ala Gly Arg Gly Arg Lys Ser Ala Ser Ser Ala Thr Ala Cys Thr Ser
        435                 440                 445             
Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr Val Ala Pro
    450                 455                 460                 
Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His Asn Pro Ala
465                 470                 475                 480 
Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu
                485                 490                 495     
Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr Gln Glu
            500                 505                 510         
Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu
        515                 520                 525             
Gly Val Trp Gln Pro Ala Ala
    530                 535 


<210> 4
<211> 1605
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence encoding mpp65

<400> 4
atggagtcgc gcggtcgccg ttgtcccgaa atgatatccg tactgggtcc catttcgggg 60
cacgtgctga aagccgtgtt tagtcgcggc gatacgccgg tgctgccgca cgagacgcga 120
ctcctgcaga cgggtatcca cgtacgcgtg agccagccct cgctgatctt ggtatcgcag 180
tacacgcccg actcgacgcc atgccaccgc ggcgacaatc agctgcaggt gcagcacacg 240
tactttacgg gcagcgaggt ggagaacgtg tcggtcaacg tgcacaaccc cacgggccga 300
agcatctgcc ccagccagga gcccatgtcg atctatgtgt acgcgctgcc gctcaagatg 360
ctgaacatcc ccagcatcaa cgtgcaccac tacccgtcgg cggccgagcg caaacaccga 420
cacctgcccg tagctgacgc tgtgattcac gcgtcgggca agcagatgtg gcaggcgcgt 480
ctcacggtct cgggactggc ctggacgcgt cagcagaacc agtggaaaga gcccgacgtc 540
tactacacgt cagcgttcgt gtttcccacc aaggacgtgg cactgcggca cgtggtgtgc 600
gcgcacgagc tggtttgctc catggagaac acgcgcgcaa ccaagatgca ggtgataggt 660
gaccagtacg tcaaggtgta cctggagtcc ttctgcgagg acgtgccctc cggcaagctc 720
tttatgcacg tcacgctggg ctctgacgtg gaagaggacc tgacgatgac ccgcaacccg 780
caacccttca tgcgccccca cgagcgcaac ggctttacgg tgttgtgtcc caaaaatatg 840
ataatcaaac cgggcaagat ctcgcacatc atgctggatg tggcttttac ctcacacgag 900
cattttgggc tgctgtgtcc caagagcatc ccgggcctga gcatctcagg taacctgttg 960
atgaacgggc agcagatctt cctggaggta caagccatac gcgagaccgt ggaactgcgt 1020
cagtacgatc ccgtggctgc gctcttcttt ttcgatatcg acttgctgct gcagcgcggg 1080
cctcagtaca gcgagcaccc caccttcacc agccagtatc gcatccaggg caagcttgag 1140
taccgacaca cctgggaccg gcacgacgag ggtgccgccc agggcgacga cgacgtctgg 1200
accagcggat cggactccga cgaagaactc gtaaccaccg agggcgggac gcccggcgtc 1260
accggcggcg gcgccatggc gggcgcctcc acttccgcgg gccgcggacg caaatcagca 1320
tcctcggcga cggcgtgcac gtcgggcgtt atgacacgcg gccgccttaa ggccgagtcc 1380
accgtcgcgc ccgaagagga caccgacgag gattccgaca acgaaatcca caatccggcc 1440
gtgttcacct ggccgccctg gcaggccggc atcctggccc gcaacctggt gcccatggtg 1500
gctacggttc agggtcagaa tctgaagtac caggaattct tctgggacgc caacgacatc 1560
taccgcatct tcgccgaatt ggaaggcgta tggcagcccg ctgcg                 1605

<210> 5
<211> 1605
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized sequence encoding mpp65

<400> 5
atggagtctc gtggtcgtcg gtgccctgag atgatctctg tgctgggacc catctctggc 60
catgtgctga aggctgtctt ctctcgggga gacacccctg tgctgcctca tgagacccgg 120
ctgcttcaga caggcatcca tgtgcgggtc tcccagccat ccctgatcct ggtctcccag 180
tacacccctg actctacccc atgccatcgg ggtgacaacc agcttcaggt gcagcacacc 240
tacttcacag gctctgaggt ggagaatgtc tctgtgaatg ttcacaaccc tacaggccgg 300
tccatctgcc catcccagga gcccatgtcc atctatgtct atgccctgcc tctgaagatg 360
ctgaacatcc catccatcaa tgtgcatcac tacccatctg ctgctgagcg gaagcatcgg 420
catctgcctg tggctgatgc tgtgatccat gcctctggca agcagatgtg gcaggctcgg 480
ctgacagtct ctggcctggc ctggactcgg cagcagaacc agtggaagga gcctgatgtc 540
tactacacct ctgcctttgt cttccccacc aaggatgtgg ctctgcggca tgtggtctgt 600
gctcatgagc tggtctgctc tatggagaac actcgggcca ccaagatgca ggtgattggt 660
gaccagtatg tgaaggtcta cctggagtcc ttctgtgagg atgtgccatc tggcaagctg 720
ttcatgcatg tgaccctggg ctctgatgtg gaggaggacc tgaccatgac tcggaaccct 780
cagccattca tgcggcctca tgagcggaat ggcttcacag tgctgtgccc taagaacatg 840
atcatcaagc ctggcaagat cagccacatc atgctggatg tggccttcac ctcccatgag 900
cactttggcc tgctgtgccc caagtccatc cctggcctgt ccatctctgg caacctgctg 960
atgaatggcc agcagatatt cctggaggtg caggccatcc gggagacagt ggagctgcgg 1020
cagtatgacc ctgtggctgc tctgttcttc tttgacattg acctgctact gcagcggggc 1080
cctcagtact ctgagcatcc caccttcacc tcccagtacc gtatccaggg caagctggag 1140
taccggcaca cctgggaccg gcatgatgag ggtgctgccc agggtgatga tgatgtctgg 1200
acctctggct ctgactctga tgaggagctg gtgaccacag agggtggcac ccctggtgtg 1260
acaggtggag gtgctatggc tggtgcctcc acctctgctg gtcggggtcg gaagtctgcc 1320
tcctctgcca cagcttgcac ctctggtgtg atgactcgtg gtcggctgaa ggctgagtcc 1380
acagtggctc ctgaggagga cacagatgag gactctgaca atgagatcca caaccctgct 1440
gtcttcacct ggcctccatg tcaggctggc atcctggctc ggaacctggt gcctatggtg 1500
gccacagtgc agggtcagaa cctgaagtac caggagttct tctgggatgc caatgacatc 1560
taccggatct ttgctgagct ggagggtgtc tgtcagcctg ctgcc                 1605

<210> 6
<211> 491
<212> PRT
<213> human cytomegalovirus

<400> 6
Met Glu Ser Ser Ala Lys Arg Lys Met Asp Pro Asp Asn Pro Asp Glu
 1               5                  10                  15      
Gly Pro Ser Ser Lys Val Pro Arg Pro Glu Thr Pro Val Thr Lys Ala
            20                  25                  30          
Thr Thr Phe Leu Gln Thr Met Leu Arg Lys Glu Val Asn Ser Gln Leu
        35                  40                  45              
Ser Leu Gly Asp Pro Leu Phe Pro Glu Leu Ala Glu Glu Ser Leu Lys
    50                  55                  60                  
Thr Phe Glu Gln Val Thr Glu Asp Cys Asn Glu Asn Pro Glu Lys Asp
65                  70                  75                  80  
Val Leu Ala Glu Leu Val Lys Gln Ile Lys Val Arg Val Asp Met Val
                85                  90                  95      
Arg His Arg Ile Lys Glu His Met Leu Lys Lys Tyr Thr Gln Thr Glu
            100                 105                 110         
Glu Lys Phe Thr Gly Ala Phe Asn Met Met Gly Gly Cys Leu Gln Asn
        115                 120                 125             
Ala Leu Asp Ile Leu Asp Lys Val His Glu Pro Phe Glu Glu Met Lys
    130                 135                 140                 
Cys Ile Gly Leu Thr Met Gln Ser Met Tyr Glu Asn Tyr Ile Val Pro
145                 150                 155                 160 
Glu Asp Lys Arg Glu Met Trp Met Ala Cys Ile Lys Glu Leu His Asp
                165                 170                 175     
Val Ser Lys Gly Ala Ala Asn Lys Leu Gly Gly Ala Leu Gln Ala Lys
            180                 185                 190         
Ala Arg Ala Lys Lys Asp Glu Leu Arg Arg Lys Met Met Tyr Met Cys
        195                 200                 205             
Tyr Arg Asn Ile Glu Phe Phe Thr Lys Asn Ser Ala Phe Pro Lys Thr
    210                 215                 220                 
Thr Asn Gly Cys Ser Gln Ala Met Ala Ala Leu Gln Asn Leu Pro Gln
225                 230                 235                 240 
Cys Ser Pro Asp Glu Ile Met Ala Tyr Ala Gln Lys Ile Phe Lys Ile
                245                 250                 255     
Leu Asp Glu Glu Arg Asp Lys Val Leu Thr His Ile Asp His Ile Phe
            260                 265                 270         
Met Asp Ile Leu Thr Thr Cys Val Glu Thr Met Cys Asn Glu Tyr Lys
        275                 280                 285             
Val Thr Ser Asp Ala Cys Met Met Thr Met Tyr Gly Gly Ile Ser Leu
    290                 295                 300                 
Leu Ser Glu Phe Cys Arg Val Leu Cys Cys Tyr Val Leu Glu Glu Thr
305                 310                 315                 320 
Ser Val Met Leu Ala Lys Arg Pro Leu Ile Thr Lys Pro Glu Val Ile
                325                 330                 335     
Ser Val Met Lys Arg Arg Ile Glu Glu Ile Cys Met Lys Val Phe Ala
            340                 345                 350         
Gln Tyr Ile Leu Gly Ala Asp Pro Leu Arg Val Cys Ser Pro Ser Val
        355                 360                 365             
Asp Asp Leu Arg Ala Ile Ala Glu Glu Ser Asp Glu Glu Glu Ala Ile
    370                 375                 380                 
Val Ala Tyr Thr Leu Ala Thr Ala Gly Val Ser Ser Ser Asp Ser Leu
385                 390                 395                 400 
Val Ser Pro Pro Glu Ser Pro Val Pro Ala Thr Ile Pro Leu Ser Ser
                405                 410                 415     
Val Ile Val Ala Glu Asn Ser Asp Gln Glu Glu Ser Glu Gln Ser Asp
            420                 425                 430         
Glu Glu Glu Glu Glu Gly Ala Gln Glu Glu Arg Glu Asp Thr Val Ser
        435                 440                 445             
Val Lys Ser Glu Pro Val Ser Glu Ile Glu Glu Val Ala Pro Glu Glu
    450                 455                 460                 
Glu Glu Asp Gly Ala Glu Glu Pro Thr Ala Ser Gly Gly Lys Ser Thr
465                 470                 475                 480 
His Pro Met Val Thr Arg Ser Lys Ala Asp Gln
                485                 490     


<210> 7
<211> 1476
<212> DNA
<213> human cytomegalovirus

<400> 7
atggagtcct ctgccaagag aaagatggac cctgataatc ctgacgaggg cccttcctcc 60
aaggtgccac ggcccgagac acccgtgacc aaggccacga cgttcctgca gactatgttg 120
aggaaggagg ttaacagtca gctgagtctg ggagacccgc tgtttccaga gttggccgaa 180
gaatccctca aaacttttga acaagtgacc gaggattgca acgagaaccc cgagaaagat 240
gtcctggcag aactcgtcaa acagattaag gttcgagtgg acatggtgcg gcatagaatc 300
aaggagcaca tgctgaaaaa atatacccag acggaagaga aattcactgg cgcctttaat 360
atgatgggag gatgtttgca gaatgcctta gatatcttag ataaggttca tgagcctttc 420
gaggagatga agtgtattgg gctaactatg cagagcatgt atgagaacta cattgtacct 480
gaggataagc gggagatgtg gatggcttgt attaaggagc tgcatgatgt gagcaagggc 540
gccgctaaca agttgggggg tgcactgcag gctaaggccc gtgctaaaaa ggatgaactt 600
aggagaaaga tgatgtatat gtgctacagg aatatagagt tctttaccaa gaactcagcc 660
ttccctaaga ccaccaatgg ctgcagtcag gccatggcgg cactgcagaa cttgcctcag 720
tgctcccctg atgagattat ggcttatgcc cagaaaatat ttaagatttt ggatgaggag 780
agagacaagg tgctcacgca cattgatcac atatttatgg atatcctcac tacatgtgtg 840
gaaacaatgt gtaatgagta caaggtcact agtgacgctt gtatgatgac catgtacggg 900
ggcatctctc tcttaagtga gttctgtcgg gtgctgtgct gctatgtctt agaggagact 960
agtgtgatgc tggccaagcg gcctctgata accaagcctg aggttatcag tgtaatgaag 1020
cgccgcattg aggagatctg catgaaggtc tttgcccagt acattctggg ggccgatcct 1080
ctgagagtct gctctcctag tgtggatgac ctacgggcca tcgccgagga gtcagatgag 1140
gaagaggcta ttgtagccta cactttggcc accgctggtg tcagctcctc tgattctctg 1200
gtgtcacccc cagagtcccc tgtacccgcg actatccctc tgtcctcagt aattgtggct 1260
gagaacagtg atcaggaaga aagtgagcag agtgatgagg aagaggagga gggtgctcag 1320
gaggagcggg aggacactgt gtctgtcaag tctgagccag tgtctgagat agaggaagtt 1380
gccccagagg aagaggagga tggtgctgag gaacccaccg cctctggagg caagagcacc 1440
caccctatgg tgactagaag caaggctgac cagtaa                           1476

<210> 8
<211> 1473
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized sequence encoding HCMV IE1

<400> 8
atggagtcct ctgccaagcg gaagatggac cctgacaacc ctgatgaggg cccatcctcc 60
aaggtgcctc ggcctgagac ccctgtgacc aaggccacca ccttcctgca gaccatgctg 120
cggaaggagg tgaactccca gctgtccctg ggcgaccctc tgttccctga gctggctgag 180
gagtccctga agacctttga gcaggtgaca gaggactgca atgagaaccc tgagaaggat 240
gtgctggctg agctggtgaa gcagatcaag gtgcgggtgg acatggtgcg gcatcggatc 300
aaggagcaca tgctgaagaa gtacacccag acagaggaga agttcacagg cgccttcaac 360
atgatgggtg gctgcctgca gaatgccctg gacatcctgg acaaggtgca tgagccattt 420
gaggagatga agtgcattgg cctgaccatg cagtccatgt atgagaacta cattgtgcct 480
gaggacaagc gggagatgtg gatggcctgc atcaaggagc tgcatgatgt ctccaagggc 540
gctgccaaca agctgggcgg tgccctgcag gccaaggccc gggccaagaa ggatgagctg 600
cggcggaaga tgatgtacat gtgctaccgg aacattgagt tcttcaccaa gaactctgcc 660
ttccccaaga ccaccaatgg ctgctcccag gccatggctg ccctgcagaa cctgccccag 720
tgctcccctg atgagatcat ggcctatgcc cagaagatat tcaagatcct ggatgaggag 780
cgggacaagg tgctgaccca cattgaccac atcttcatgg acatcctgac cacctgtgtg 840
gagaccatgt gcaatgagta caaggtgacc tctgatgcct gcatgatgac catgtatggc 900
ggcatctccc tgctgtctga gttctgccgg gtgctgtgct gctatgtgct ggaggagacc 960
tctgtgatgc tggccaagcg gcccctgatc accaagcctg aggtgatctc tgtgatgaag 1020
cggcggattg aggagatcag catgaaggtc tttgcccagt acatcctggg cgctgaccct 1080
ctgcgggtct gctccccatc tgtggatgac ctgcgggcca ttgctgagga gtctgatgag 1140
gaggaggcca ttgtggccta caccctggcc acagctggcg tctcctcctc tgactccctg 1200
gtctcccccc ctgagtcccc tgtgcctgcc accatccccc tgtcctctgt gattgtggct 1260
gagaactctg accaggagga gtctgagcag tctgatgagg aggaggagga gggtgcccag 1320
gaggagcggg aggacacagt ctctgtgaag tctgagcctg tctctgagat tgaggaggtg 1380
gcccctgagg aggaggagga tggcgctgag gagcccacag cctctggcgg caagtccacc 1440
catcccatgg tgacccggtc caaggctgac cag                              1473

<210> 9
<211> 416
<212> PRT
<213> Artificial Sequence

<220> 
<223> protein variant of HCMV IE1 (mIE1)

<400> 9
Met Pro Glu Lys Asp Val Leu Ala Glu Leu Val Lys Gln Ile Lys Val
 1               5                  10                  15      
Arg Val Asp Met Val Arg His Arg Ile Lys Glu His Met Leu Lys Lys
            20                  25                  30          
Tyr Thr Gln Thr Glu Glu Lys Phe Thr Gly Ala Phe Asn Met Met Gly
        35                  40                  45              
Gly Cys Leu Gln Asn Ala Leu Asp Ile Leu Asp Lys Val His Glu Pro
    50                  55                  60                  
Phe Glu Glu Met Lys Cys Ile Gly Leu Thr Met Gln Ser Met Tyr Glu
65                  70                  75                  80  
Asn Tyr Ile Val Pro Glu Asp Lys Arg Glu Met Trp Met Ala Cys Ile
                85                  90                  95      
Lys Glu Leu His Asp Val Ser Lys Gly Ala Ala Asn Lys Leu Gly Gly
            100                 105                 110         
Ala Leu Gln Ala Lys Ala Arg Ala Lys Lys Asp Glu Leu Arg Arg Lys
        115                 120                 125             
Met Met Tyr Met Cys Tyr Arg Asn Ile Glu Phe Phe Thr Lys Asn Ser
    130                 135                 140                 
Ala Phe Pro Lys Thr Thr Asn Gly Cys Ser Gln Ala Met Ala Ala Leu
145                 150                 155                 160 
Gln Asn Leu Pro Gln Cys Ser Pro Asp Glu Ile Met Ala Tyr Ala Gln
                165                 170                 175     
Lys Ile Phe Lys Ile Leu Asp Glu Glu Arg Asp Lys Val Leu Thr His
            180                 185                 190         
Ile Asp His Ile Phe Met Asp Ile Leu Thr Thr Cys Val Glu Thr Met
        195                 200                 205             
Cys Asn Glu Tyr Lys Val Thr Ser Asp Ala Cys Met Met Thr Met Tyr
    210                 215                 220                 
Gly Gly Ile Ser Leu Leu Ser Glu Phe Cys Arg Val Leu Cys Cys Tyr
225                 230                 235                 240 
Val Leu Glu Glu Thr Ser Val Met Leu Ala Lys Arg Pro Leu Ile Thr
                245                 250                 255     
Lys Pro Glu Val Ile Ser Val Met Gly Gly Gly Ile Glu Glu Ile Cys
            260                 265                 270         
Met Lys Val Phe Ala Gln Tyr Ile Leu Gly Ala Asp Pro Leu Arg Val
        275                 280                 285             
Cys Ser Pro Ser Val Asp Asp Leu Arg Ala Ile Ala Glu Glu Ser Asp
    290                 295                 300                 
Glu Glu Glu Ala Ile Val Ala Tyr Thr Leu Ala Thr Ala Gly Val Ser
305                 310                 315                 320 
Ser Ser Asp Ser Leu Val Ser Pro Pro Glu Ser Pro Val Pro Ala Thr
                325                 330                 335     
Ile Pro Leu Ser Ser Val Ile Val Ala Glu Asn Ser Asp Gln Glu Glu
            340                 345                 350         
Ser Glu Gln Ser Asp Glu Glu Glu Glu Glu Gly Ala Gln Glu Glu Arg
        355                 360                 365             
Glu Asp Thr Val Ser Val Lys Ser Glu Pro Val Ser Glu Ile Glu Glu
    370                 375                 380                 
Val Ala Pro Glu Glu Glu Glu Asp Gly Ala Glu Glu Pro Thr Ala Ser
385                 390                 395                 400 
Gly Gly Lys Ser Thr His Pro Met Val Thr Arg Ser Lys Ala Asp Gln
                405                 410                 415     


<210> 10
<211> 1248
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence encoding mIE1

<400> 10
atgcctgaga aggatgtgct ggctgagctg gtgaagcaga tcaaggtgcg ggtggacatg 60
gtgcggcatc ggatcaagga gcacatgctg aagaagtaca cccagacaga ggagaagttc 120
acaggcgcct tcaacatgat gggtggctgc ctgcagaatg ccctggacat cctggacaag 180
gtgcatgagc catttgagga gatgaagtgc attggcctga ccatgcagtc catgtatgag 240
aactacattg tgcctgagga caagcgggag atgtggatgg cctgcatcaa ggagctgcat 300
gatgtctcca agggcgctgc caacaagctg ggcggtgccc tgcaggccaa ggcccgggcc 360
aagaaggatg agctgcggcg gaagatgatg tacatgtgct accggaacat tgagttcttc 420
accaagaact ctgccttccc caagaccacc aatggctgct cccaggccat ggctgccctg 480
cagaacctgc cccagtgctc ccctgatgag atcatggcct atgcccagaa gatattcaag 540
atcctggatg aggagcggga caaggtgctg acccacattg accacatctt catggacatc 600
ctgaccacct gtgtggagac catgtgcaat gagtacaagg tgacctctga tgcctgcatg 660
atgaccatgt atggcggcat ctccctgctg tctgagttct gccgggtgct gtgctgctat 720
gtgctggagg agacctctgt gatgctggcc aagcggcccc tgatcaccaa gcctgaggtg 780
atctctgtga tgggtggcgg tattgaggag atcagcatga aggtctttgc ccagtacatc 840
ctgggcgctg accctctgcg ggtctgctcc ccatctgtgg atgacctgcg ggccattgct 900
gaggagtctg atgaggagga ggccattgtg gcctacaccc tggccacagc tggcgtctcc 960
tcctctgact ccctggtctc cccccctgag tcccctgtgc ctgccaccat ccccctgtcc 1020
tctgtgattg tggctgagaa ctctgaccag gaggagtctg agcagtctga tgaggaggag 1080
gaggagggtg cccaggagga gcgggaggac acagtctctg tgaagtctga gcctgtctct 1140
gagattgagg aggtggcccc tgaggaggag gaggatggcg ctgaggagcc cacagcctct 1200
ggcggcaagt ccacccatcc catggtgacc cggtccaagg ctgaccag              1248

<210> 11
<211> 580
<212> PRT
<213> human cytomegalovirus

<400> 11
Met Glu Ser Ser Ala Lys Arg Lys Met Asp Pro Asp Asn Pro Asp Glu
 1               5                  10                  15      
Gly Pro Ser Ser Lys Val Pro Arg Pro Glu Thr Pro Val Thr Lys Ala
            20                  25                  30          
Thr Thr Phe Leu Gln Thr Met Leu Arg Lys Glu Val Asn Ser Gln Leu
        35                  40                  45              
Ser Leu Gly Asp Pro Leu Phe Pro Glu Leu Ala Glu Glu Ser Leu Lys
    50                  55                  60                  
Thr Phe Glu Gln Val Thr Glu Asp Cys Asn Glu Asn Pro Glu Lys Asp
65                  70                  75                  80  
Val Leu Ala Glu Leu Gly Asp Ile Leu Ala Gln Ala Val Asn His Ala
                85                  90                  95      
Gly Ile Asp Ser Ser Ser Thr Gly Pro Thr Leu Thr Thr His Ser Cys
            100                 105                 110         
Ser Val Ser Ser Ala Pro Leu Asn Lys Pro Thr Pro Thr Ser Val Ala
        115                 120                 125             
Val Thr Asn Thr Pro Leu Pro Gly Ala Ser Ala Thr Pro Glu Leu Ser
    130                 135                 140                 
Pro Arg Lys Lys Pro Arg Lys Thr Thr Arg Pro Phe Lys Val Ile Ile
145                 150                 155                 160 
Lys Pro Pro Val Pro Pro Ala Pro Ile Met Leu Pro Leu Ile Lys Gln
                165                 170                 175     
Glu Asp Ile Lys Pro Glu Pro Asp Phe Thr Ile Gln Tyr Arg Asn Lys
            180                 185                 190         
Ile Ile Asp Thr Ala Gly Cys Ile Val Ile Ser Asp Ser Glu Glu Glu
        195                 200                 205             
Gln Gly Glu Glu Val Glu Thr Arg Gly Ala Thr Ala Ser Ser Pro Ser
    210                 215                 220                 
Thr Gly Ser Gly Thr Pro Arg Val Thr Ser Pro Thr His Pro Leu Ser
225                 230                 235                 240 
Gln Met Asn His Pro Pro Leu Pro Asp Pro Leu Gly Arg Pro Asp Glu
                245                 250                 255     
Asp Ser Ser Ser Ser Ser Ser Ser Ser Cys Ser Ser Ala Ser Asp Ser
            260                 265                 270         
Glu Ser Glu Ser Glu Glu Met Lys Cys Ser Ser Gly Gly Gly Ala Ser
        275                 280                 285             
Val Thr Ser Ser His His Gly Arg Gly Gly Phe Gly Gly Ala Ala Ser
    290                 295                 300                 
Ser Ser Leu Leu Ser Cys Gly His Gln Ser Ser Gly Gly Ala Ser Thr
305                 310                 315                 320 
Gly Pro Arg Lys Lys Lys Ser Lys Arg Ile Ser Glu Leu Asp Asn Glu
                325                 330                 335     
Lys Val Arg Asn Ile Met Lys Asp Lys Asn Thr Pro Phe Cys Thr Pro
            340                 345                 350         
Asn Val Gln Thr Arg Arg Gly Arg Val Lys Ile Asp Glu Val Ser Arg
        355                 360                 365             
Met Phe Arg Asn Thr Asn Arg Ser Leu Glu Tyr Lys Asn Leu Pro Phe
    370                 375                 380                 
Thr Ile Pro Ser Met His Gln Val Leu Asp Glu Ala Ile Lys Ala Cys
385                 390                 395                 400 
Lys Thr Met Gln Val Asn Asn Lys Gly Ile Gln Ile Ile Tyr Thr Arg
                405                 410                 415     
Asn His Glu Val Lys Ser Glu Val Asp Ala Val Arg Cys Arg Leu Gly
            420                 425                 430         
Thr Met Cys Asn Leu Ala Leu Ser Thr Pro Phe Leu Met Glu His Thr
        435                 440                 445             
Met Pro Val Thr His Pro Pro Glu Val Ala Gln Arg Thr Ala Asp Ala
    450                 455                 460                 
Cys Asn Glu Gly Val Lys Ala Ala Trp Ser Leu Lys Glu Leu His Thr
465                 470                 475                 480 
His Gln Leu Cys Pro Arg Ser Ser Asp Tyr Arg Asn Met Ile Ile His
                485                 490                 495     
Ala Ala Thr Pro Val Asp Leu Leu Gly Ala Leu Asn Leu Cys Leu Pro
            500                 505                 510         
Leu Met Gln Lys Phe Pro Lys Gln Val Met Val Arg Ile Phe Ser Thr
        515                 520                 525             
Asn Gln Gly Gly Phe Met Leu Pro Ile Tyr Glu Thr Ala Ala Lys Ala
    530                 535                 540                 
Tyr Ala Val Gly Gln Phe Glu Gln Pro Thr Glu Thr Pro Pro Glu Asp
545                 550                 555                 560 
Leu Asp Thr Leu Ser Leu Ala Ile Glu Ala Ala Ile Gln Asp Leu Arg
                565                 570                 575     
Asn Lys Ser Gln
            580 


<210> 12
<211> 1743
<212> DNA
<213> human cytomegalovirus

<400> 12
atggagtcct ctgccaagag aaagatggac cctgataatc ctgacgaggg cccttcctcc 60
aaggtgccac ggcccgagac acccgtgacc aaggccacga cgttcctgca gactatgttg 120
aggaaggagg ttaacagtca gctgagtctg ggagacccgc tgtttccaga gttggccgaa 180
gaatccctca aaacttttga acaagtgacc gaggattgca acgagaaccc cgagaaagat 240
gtcctggcag aactcggtga catcctcgcc caggctgtca atcatgccgg tatcgattcc 300
agtagcaccg gccccacgct gacaacccac tcttgcagcg ttagcagcgc ccctcttaac 360
aagccgaccc ccaccagcgt cgcggttact aacactcctc tccccggggc atccgctact 420
cccgagctca gcccgcgtaa gaaaccgcgc aaaaccacgc gtcctttcaa ggtgattatt 480
aaaccgcccg tgcctcccgc gcctatcatg ctgcccctca tcaaacagga agacatcaag 540
cccgagcccg actttaccat ccagtaccgc aacaagatta tcgataccgc cggctgtatc 600
gtgatctctg atagcgagga agaacagggt gaagaagtcg aaacccgcgg tgctaccgcg 660
tcttcccctt ccaccggcag cggcacgccg cgagtgacct ctcccacgca cccgctctcc 720
cagatgaacc accctcctct tcccgatccc ttgggccggc ccgatgaaga tagttcctct 780
tcgtcttcct cctcctgcag ttcggcttcg gactcggaga gtgagtccga ggagatgaaa 840
tgcagcagtg gcggaggagc atccgtgacc tcgagccacc atgggcgcgg cggttttggt 900
ggcgcggcct cctcctctct gctgagctgc ggccatcaga gcagcggcgg ggcgagcacc 960
ggaccccgca agaagaagag caaacgcatc tccgagttgg acaacgagaa ggtgcgcaat 1020
atcatgaaag ataagaacac ccccttctgc acacccaacg tgcagactcg gcggggtcgc 1080
gtcaagattg acgaggtgag ccgcatgttc cgcaacacca atcgctctct tgagtacaag 1140
aacctgccct tcacgattcc cagtatgcac caggtgttag atgaggccat caaagcctgc 1200
aaaaccatgc aggtgaacaa caagggcatc cagattatct acacccgcaa tcatgaggtg 1260
aagagtgagg tggatgcggt gcggtgtcgc ctgggcacca tgtgcaacct ggccctctcc 1320
actcccttcc tcatggagca caccatgccc gtgacacatc cacccgaagt ggcgcagcgc 1380
acagccgatg cttgtaacga aggcgtcaag gccgcgtgga gcctcaaaga attgcacacc 1440
caccaattat gcccccgttc ctccgattac cgcaacatga tcatccacgc tgccaccccc 1500
gtggacctgt tgggcgctct caacctgtgc ctgcccctga tgcaaaagtt tcccaaacag 1560
gtcatggtgc gcatcttctc caccaaccag ggtgggttca tgctgcctat ctacgagacg 1620
gccgcgaagg cctacgccgt ggggcagttt gagcagccca ccgagacccc tcccgaagac 1680
ctggacaccc tgagcctggc catcgaggca gccatccagg acctgaggaa caagtctcag 1740
taa                                                               1743

<210> 13
<211> 1740
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized sequence encoding HCMV (IE2)

<400> 13
atggagtcct ctgccaagcg gaagatggac cctgacaacc ctgatgaggg cccatcctcc 60
aaggtgcccc ggcctgagac ccctgtgacc aaggccacca ccttcctgca gaccatgctg 120
cggaaggagg tgaactccca gctgtccctg ggcgaccccc tgttccctga gctggctgag 180
gagtccctga agacctttga gcaggtgaca gaggactgca atgagaaccc tgagaaggat 240
gtgctggctg agctgggcga catcctggcc caggctgtga accatgctgg cattgactcc 300
tcctccacag gccccaccct gaccacccac tcctgctctg tctcctctgc ccccctgaac 360
aagcccaccc ccacctctgt ggctgtgacc aacacccccc tgcctggcgc ctctgccacc 420
cctgagctgt ccccccggaa gaagccccgg aagaccaccc ggccattcaa ggtgatcatc 480
aagccccctg tgccccctgc ccccatcatg ctgcccctga tcaagcagga ggacatcaag 540
cctgagcctg acttcaccat ccagtaccgg aacaagatca ttgacacagc tggctgcatt 600
gtgatctctg actctgagga ggagcagggc gaggaggtgg agacccgggg cgccacagcc 660
tcctccccat ccacaggctc tggcaccccc cgggtgacct cccccaccca tcccctgtcc 720
cagatgaacc atccccccct gcctgacccc ctgggccggc ctgatgagga ctcctcctcc 780
tcctcctcct cctcctgctc ctctgcctct gactctgagt ctgagtctga ggagatgaag 840
tgctcctctg gcggcggcgc ctctgtgacc tcctcccatc atggccgggg cggctttggc 900
ggcgctgcct cctcctccct gctgtcctgt ggccatcagt cctctggcgg cgcctccaca 960
ggcccccgga agaagaagtc caagcggatc tctgagctgg acaatgagaa ggtgcggaac 1020
atcatgaagg acaagaacac cccattctgc acccccaatg tgcagacccg gcggggccgg 1080
gtgaagattg atgaggtctc ccggatgttc cggaacacca accggtccct ggagtacaag 1140
aacctgccat tcaccatccc atccatgcat caggtgctgg atgaggccat caaggcctgc 1200
aagaccatgc aggtgaacaa caagggcatc cagatcatct acacccggaa ccatgaggtg 1260
aagtctgagg tggatgctgt gcggtgccgg ctgggcacca tgtgcaacct ggccctgtcc 1320
accccattcc tgatggagca caccatgcct gtgacccatc cccctgaggt ggcccagcgg 1380
acagctgatg cctgcaatga gggcgtgaag gctgcctggt ccctgaagga gctgcacacc 1440
catcagctgt gcccccggtc ctctgactac cggaacatga tcatccatgc tgccacccct 1500
gtggacctgc tgggcgccct gaacctgtgc ctgcccctga tgcagaagtt ccccaagcag 1560
gtgatggtgc ggatcttctc caccaaccag ggcggcttca tgctgcccat ctatgagaca 1620
gctgccaagg cctatgctgt gggccagttt gagcagccca cagagacccc ccctgaggac 1680
ctggacaccc tgtccctggc cattgaggct gccatccagg acctgcggaa caagtcccag 1740


<210> 14
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> protein variant of HCMV IE2 (IE2(H2A))

<400> 14
Met Glu Ser Ser Ala Lys Arg Lys Met Asp Pro Asp Asn Pro Asp Glu
 1               5                  10                  15      
Gly Pro Ser Ser Lys Val Pro Arg Pro Glu Thr Pro Val Thr Lys Ala
            20                  25                  30          
Thr Thr Phe Leu Gln Thr Met Leu Arg Lys Glu Val Asn Ser Gln Leu
        35                  40                  45              
Ser Leu Gly Asp Pro Leu Phe Pro Glu Leu Ala Glu Glu Ser Leu Lys
    50                  55                  60                  
Thr Phe Glu Gln Val Thr Glu Asp Cys Asn Glu Asn Pro Glu Lys Asp
65                  70                  75                  80  
Val Leu Ala Glu Leu Gly Asp Ile Leu Ala Gln Ala Val Asn His Ala
                85                  90                  95      
Gly Ile Asp Ser Ser Ser Thr Gly Pro Thr Leu Thr Thr His Ser Cys
            100                 105                 110         
Ser Val Ser Ser Ala Pro Leu Asn Lys Pro Thr Pro Thr Ser Val Ala
        115                 120                 125             
Val Thr Asn Thr Pro Leu Pro Gly Ala Ser Ala Thr Pro Glu Leu Ser
    130                 135                 140                 
Pro Arg Lys Lys Pro Arg Lys Thr Thr Arg Pro Phe Lys Val Ile Ile
145                 150                 155                 160 
Lys Pro Pro Val Pro Pro Ala Pro Ile Met Leu Pro Leu Ile Lys Gln
                165                 170                 175     
Glu Asp Ile Lys Pro Glu Pro Asp Phe Thr Ile Gln Tyr Arg Asn Lys
            180                 185                 190         
Ile Ile Asp Thr Ala Gly Cys Ile Val Ile Ser Asp Ser Glu Glu Glu
        195                 200                 205             
Gln Gly Glu Glu Val Glu Thr Arg Gly Ala Thr Ala Ser Ser Pro Ser
    210                 215                 220                 
Thr Gly Ser Gly Thr Pro Arg Val Thr Ser Pro Thr His Pro Leu Ser
225                 230                 235                 240 
Gln Met Asn His Pro Pro Leu Pro Asp Pro Leu Gly Arg Pro Asp Glu
                245                 250                 255     
Asp Ser Ser Ser Ser Ser Ser Ser Ser Cys Ser Ser Ala Ser Asp Ser
            260                 265                 270         
Glu Ser Glu Ser Glu Glu Met Lys Cys Ser Ser Gly Gly Gly Ala Ser
        275                 280                 285             
Val Thr Ser Ser His His Gly Arg Gly Gly Phe Gly Gly Ala Ala Ser
    290                 295                 300                 
Ser Ser Leu Leu Ser Cys Gly His Gln Ser Ser Gly Gly Ala Ser Thr
305                 310                 315                 320 
Gly Pro Arg Lys Lys Lys Ser Lys Arg Ile Ser Glu Leu Asp Asn Glu
                325                 330                 335     
Lys Val Arg Asn Ile Met Lys Asp Lys Asn Thr Pro Phe Cys Thr Pro
            340                 345                 350         
Asn Val Gln Thr Arg Arg Gly Arg Val Lys Ile Asp Glu Val Ser Arg
        355                 360                 365             
Met Phe Arg Asn Thr Asn Arg Ser Leu Glu Tyr Lys Asn Leu Pro Phe
    370                 375                 380                 
Thr Ile Pro Ser Met His Gln Val Leu Asp Glu Ala Ile Lys Ala Cys
385                 390                 395                 400 
Lys Thr Met Gln Val Asn Asn Lys Gly Ile Gln Ile Ile Tyr Thr Arg
                405                 410                 415     
Asn His Glu Val Lys Ser Glu Val Asp Ala Val Arg Cys Arg Leu Gly
            420                 425                 430         
Thr Met Cys Asn Leu Ala Leu Ser Thr Pro Phe Leu Met Glu Ala Thr
        435                 440                 445             
Met Pro Val Thr Ala Pro Pro Glu Val Ala Gln Arg Thr Ala Asp Ala
    450                 455                 460                 
Cys Asn Glu Gly Val Lys Ala Ala Trp Ser Leu Lys Glu Leu His Thr
465                 470                 475                 480 
His Gln Leu Cys Pro Arg Ser Ser Asp Tyr Arg Asn Met Ile Ile His
                485                 490                 495     
Ala Ala Thr Pro Val Asp Leu Leu Gly Ala Leu Asn Leu Cys Leu Pro
            500                 505                 510         
Leu Met Gln Lys Phe Pro Lys Gln Val Met Val Arg Ile Phe Ser Thr
        515                 520                 525             
Asn Gln Gly Gly Phe Met Leu Pro Ile Tyr Glu Thr Ala Ala Lys Ala
    530                 535                 540                 
Tyr Ala Val Gly Gln Phe Glu Gln Pro Thr Glu Thr Pro Pro Glu Asp
545                 550                 555                 560 
Leu Asp Thr Leu Ser Leu Ala Ile Glu Ala Ala Ile Gln Asp Leu Arg
                565                 570                 575     
Asn Lys Ser Gln
            580 


<210> 15
<211> 1740
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized sequence encoding IE2(H2A)

<400> 15
atggagtcct ctgccaagcg gaagatggac cctgacaacc ctgatgaggg cccatcctcc 60
aaggtgcccc ggcctgagac ccctgtgacc aaggccacca ccttcctgca gaccatgctg 120
cggaaggagg tgaactccca gctgtccctg ggcgaccccc tgttccctga gctggctgag 180
gagtccctga agacctttga gcaggtgaca gaggactgca atgagaaccc tgagaaggat 240
gtgctggctg agctgggcga catcctggcc caggctgtga accatgctgg cattgactcc 300
tcctccacag gccccaccct gaccacccac tcctgctctg tctcctctgc ccccctgaac 360
aagcccaccc ccacctctgt ggctgtgacc aacacccccc tgcctggcgc ctctgccacc 420
cctgagctgt ccccccggaa gaagccccgg aagaccaccc ggccattcaa ggtgatcatc 480
aagccccctg tgccccctgc ccccatcatg ctgcccctga tcaagcagga ggacatcaag 540
cctgagcctg acttcaccat ccagtaccgg aacaagatca ttgacacagc tggctgcatt 600
gtgatctctg actctgagga ggagcagggc gaggaggtgg agacccgggg cgccacagcc 660
tcctccccat ccacaggctc tggcaccccc cgggtgacct cccccaccca tcccctgtcc 720
cagatgaacc atccccccct gcctgacccc ctgggccggc ctgatgagga ctcctcctcc 780
tcctcctcct cctcctgctc ctctgcctct gactctgagt ctgagtctga ggagatgaag 840
tgctcctctg gcggcggcgc ctctgtgacc tcctcccatc atggccgggg cggctttggc 900
ggcgctgcct cctcctccct gctgtcctgt ggccatcagt cctctggcgg cgcctccaca 960
ggcccccgga agaagaagtc caagcggatc tctgagctgg acaatgagaa ggtgcggaac 1020
atcatgaagg acaagaacac cccattctgc acccccaatg tgcagacccg gcggggccgg 1080
gtgaagattg atgaggtctc ccggatgttc cggaacacca accggtccct ggagtacaag 1140
aacctgccat tcaccatccc atccatgcat caggtgctgg atgaggccat caaggcctgc 1200
aagaccatgc aggtgaacaa caagggcatc cagatcatct acacccggaa ccatgaggtg 1260
aagtctgagg tggatgctgt gcggtgccgg ctgggcacca tgtgcaacct ggccctgtcc 1320
accccattcc tgatggaggc caccatgcct gtgacagccc cccctgaggt ggcccagcgg 1380
acagctgatg cctgcaatga gggcgtgaag gctgcctggt ccctgaagga gctgcacacc 1440
catcagctgt gcccccggtc ctctgactac cggaacatga tcatccatgc tgccacccct 1500
gtggacctgc tgggcgccct gaacctgtgc ctgcccctga tgcagaagtt ccccaagcag 1560
gtgatggtgc ggatcttctc caccaaccag ggcggcttca tgctgcccat ctatgagaca 1620
gctgccaagg cctatgctgt gggccagttt gagcagccca cagagacccc ccctgaggac 1680
ctggacaccc tgtccctggc cattgaggct gccatccagg acctgcggaa caagtcccag 1740


<210> 16
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> protein variant of HCMV IE2 (mIE2)

<400> 16
Met Gly Asp Ile Leu Ala Gln Ala Val Asn His Ala Gly Ile Asp Ser
 1               5                  10                  15      
Ser Ser Thr Gly Pro Thr Leu Thr Thr His Ser Cys Ser Val Ser Ser
            20                  25                  30          
Ala Pro Leu Asn Lys Pro Thr Pro Thr Ser Val Ala Val Thr Asn Thr
        35                  40                  45              
Pro Leu Pro Gly Ala Ser Ala Thr Pro Glu Leu Ser Pro Ser Ser Gly
    50                  55                  60                  
Pro Arg Lys Thr Thr Arg Pro Phe Lys Val Ile Ile Lys Pro Pro Val
65                  70                  75                  80  
Pro Pro Ala Pro Ile Met Leu Pro Leu Ile Lys Gln Glu Asp Ile Lys
                85                  90                  95      
Pro Glu Pro Asp Phe Thr Ile Gln Tyr Arg Asn Lys Ile Ile Asp Thr
            100                 105                 110         
Ala Gly Cys Ile Val Ile Ser Asp Ser Glu Glu Glu Gln Gly Glu Glu
        115                 120                 125             
Val Glu Thr Arg Gly Ala Thr Ala Ser Ser Pro Ser Thr Gly Ser Gly
    130                 135                 140                 
Thr Pro Arg Val Thr Ser Pro Thr His Pro Leu Ser Gln Met Asn His
145                 150                 155                 160 
Pro Pro Leu Pro Asp Pro Leu Gly Arg Pro Asp Glu Asp Ser Ser Ser
                165                 170                 175     
Ser Ser Ser Ser Ser Cys Ser Ser Ala Ser Asp Ser Glu Ser Glu Ser
            180                 185                 190         
Glu Glu Met Lys Cys Ser Ser Gly Gly Gly Ala Ser Val Thr Ser Ser
        195                 200                 205             
His His Gly Arg Gly Gly Phe Gly Gly Ala Ala Ser Ser Ser Leu Leu
    210                 215                 220                 
Ser Cys Gly His Gln Ser Ser Gly Gly Ala Ser Thr Gly Pro Arg Ser
225                 230                 235                 240 
Ser Gly Ser Lys Arg Ile Ser Glu Leu Asp Asn Glu Lys Val Arg Asn
                245                 250                 255     
Ile Met Lys Asp Lys Asn Thr Pro Phe Cys Thr Pro Asn Val Gln Thr
            260                 265                 270         
Arg Arg Gly Arg Val Lys Ile Asp Glu Val Ser Arg Met Phe Arg Asn
        275                 280                 285             
Thr Asn Arg Ser Leu Glu Tyr Lys Asn Leu Pro Phe Thr Ile Pro Ser
    290                 295                 300                 
Met His Gln Val Leu Asp Glu Ala Ile Lys Ala Cys Lys Thr Met Gln
305                 310                 315                 320 
Val Asn Asn Lys Gly Ile Gln Ile Ile Tyr Thr Arg Asn His Glu Val
                325                 330                 335     
Lys Ser Glu Val Asp Ala Val Arg Cys Arg Leu Gly Thr Met Cys Asn
            340                 345                 350         
Leu Ala Leu Ser Thr Pro Phe Leu Met Glu His Thr Met Pro Val Thr
        355                 360                 365             
His Pro Pro Glu Val Ala Gln Arg Thr Ala Asp Ala Cys Asn Glu Gly
    370                 375                 380                 
Val Lys Ala Ala Trp Ser Leu Lys Glu Leu His Thr His Gln Leu Cys
385                 390                 395                 400 
Pro Arg Ser Ser Asp Tyr Arg Asn Met Ile Ile His Ala Ala Thr Pro
                405                 410                 415     
Val Asp Leu Leu Gly Ala Leu Asn Leu Cys Leu Pro Leu Met Gln Lys
            420                 425                 430         
Phe Pro Lys Gln Val Met Val Arg Ile Phe Ser Thr Asn Gln Gly Gly
        435                 440                 445             
Phe Met Leu Pro Ile Tyr Glu Thr Ala Ala Lys Ala Tyr Ala Val Gly
    450                 455                 460                 
Gln Phe Glu Gln Pro Thr Glu Thr Pro Pro Glu Asp Leu Asp Thr Leu
465                 470                 475                 480 
Ser Leu Ala Ile Glu Ala Ala Ile Gln Asp Leu Arg Asn Lys Ser Gln
                485                 490                 495     


<210> 17
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized sequence encoding mIE2

<400> 17
atgggcgaca tcctggccca ggctgtgaac catgctggca ttgactcctc ctccacaggc 60
cccaccctga ccacccactc ctgctctgtc tcctctgccc ccctgaacaa gcccaccccc 120
acctctgtgg ctgtgaccaa cacccccctg cctggcgcct ctgccacccc tgagctgtcc 180
ccctcttctg gtccccggaa gaccacccgg ccattcaagg tgatcatcaa gccccctgtg 240
ccccctgccc ccatcatgct gcccctgatc aagcaggagg acatcaagcc tgagcctgac 300
ttcaccatcc agtaccggaa caagatcatt gacacagctg gctgcattgt gatctctgac 360
tctgaggagg agcagggcga ggaggtggag acccggggcg ccacagcctc ctccccatcc 420
acaggctctg gcaccccccg ggtgacctcc cccacccatc ccctgtccca gatgaaccat 480
ccccccctgc ctgaccccct gggccggcct gatgaggact cctcctcctc ctcctcctcc 540
tcctgctcct ctgcctctga ctctgagtct gagtctgagg agatgaagtg ctcctctggc 600
ggcggcgcct ctgtgacctc ctcccatcat ggccggggcg gctttggcgg cgctgcctcc 660
tcctccctgc tgtcctgtgg ccatcagtcc tctggcggcg cctccacagg cccccggtct 720
tctggttcca agcggatctc tgagctggac aatgagaagg tgcggaacat catgaaggac 780
aagaacaccc cattctgcac ccccaatgtg cagacccggc ggggccgggt gaagattgat 840
gaggtctccc ggatgttccg gaacaccaac cggtccctgg agtacaagaa cctgccattc 900
accatcccat ccatgcatca ggtgctggat gaggccatca aggcctgcaa gaccatgcag 960
gtgaacaaca agggcatcca gatcatctac acccggaacc atgaggtgaa gtctgaggtg 1020
gatgctgtgc ggtgccggct gggcaccatg tgcaacctgg ccctgtccac cccattcctg 1080
atggagcaca ccatgcctgt gacccatccc cctgaggtgg cccagcggac agctgatgcc 1140
tgcaatgagg gcgtgaaggc tgcctggtcc ctgaaggagc tgcacaccca tcagctgtgc 1200
ccccggtcct ctgactaccg gaacatgatc atccatgctg ccacccctgt ggacctgctg 1260
ggcgccctga acctgtgcct gcccctgatg cagaagttcc ccaagcaggt gatggtgcgg 1320
atcttctcca ccaaccaggg cggcttcatg ctgcccatct atgagacagc tgccaaggcc 1380
tatgctgtgg gccagtttga gcagcccaca gagacccccc ctgaggacct ggacaccctg 1440
tccctggcca ttgaggctgc catccaggac ctgcggaaca agtcccag              1488

<210> 18
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> protein variant of HCMV IE2 (mIE2(H2A))

<400> 18
Met Gly Asp Ile Leu Ala Gln Ala Val Asn His Ala Gly Ile Asp Ser
 1               5                  10                  15      
Ser Ser Thr Gly Pro Thr Leu Thr Thr His Ser Cys Ser Val Ser Ser
            20                  25                  30          
Ala Pro Leu Asn Lys Pro Thr Pro Thr Ser Val Ala Val Thr Asn Thr
        35                  40                  45              
Pro Leu Pro Gly Ala Ser Ala Thr Pro Glu Leu Ser Pro Ser Ser Gly
    50                  55                  60                  
Pro Arg Lys Thr Thr Arg Pro Phe Lys Val Ile Ile Lys Pro Pro Val
65                  70                  75                  80  
Pro Pro Ala Pro Ile Met Leu Pro Leu Ile Lys Gln Glu Asp Ile Lys
                85                  90                  95      
Pro Glu Pro Asp Phe Thr Ile Gln Tyr Arg Asn Lys Ile Ile Asp Thr
            100                 105                 110         
Ala Gly Cys Ile Val Ile Ser Asp Ser Glu Glu Glu Gln Gly Glu Glu
        115                 120                 125             
Val Glu Thr Arg Gly Ala Thr Ala Ser Ser Pro Ser Thr Gly Ser Gly
    130                 135                 140                 
Thr Pro Arg Val Thr Ser Pro Thr His Pro Leu Ser Gln Met Asn His
145                 150                 155                 160 
Pro Pro Leu Pro Asp Pro Leu Gly Arg Pro Asp Glu Asp Ser Ser Ser
                165                 170                 175     
Ser Ser Ser Ser Ser Cys Ser Ser Ala Ser Asp Ser Glu Ser Glu Ser
            180                 185                 190         
Glu Glu Met Lys Cys Ser Ser Gly Gly Gly Ala Ser Val Thr Ser Ser
        195                 200                 205             
His His Gly Arg Gly Gly Phe Gly Gly Ala Ala Ser Ser Ser Leu Leu
    210                 215                 220                 
Ser Cys Gly His Gln Ser Ser Gly Gly Ala Ser Thr Gly Pro Arg Ser
225                 230                 235                 240 
Ser Gly Ser Lys Arg Ile Ser Glu Leu Asp Asn Glu Lys Val Arg Asn
                245                 250                 255     
Ile Met Lys Asp Lys Asn Thr Pro Phe Cys Thr Pro Asn Val Gln Thr
            260                 265                 270         
Arg Arg Gly Arg Val Lys Ile Asp Glu Val Ser Arg Met Phe Arg Asn
        275                 280                 285             
Thr Asn Arg Ser Leu Glu Tyr Lys Asn Leu Pro Phe Thr Ile Pro Ser
    290                 295                 300                 
Met His Gln Val Leu Asp Glu Ala Ile Lys Ala Cys Lys Thr Met Gln
305                 310                 315                 320 
Val Asn Asn Lys Gly Ile Gln Ile Ile Tyr Thr Arg Asn His Glu Val
                325                 330                 335     
Lys Ser Glu Val Asp Ala Val Arg Cys Arg Leu Gly Thr Met Cys Asn
            340                 345                 350         
Leu Ala Leu Ser Thr Pro Phe Leu Met Glu Ala Thr Met Pro Val Thr
        355                 360                 365             
Ala Pro Pro Glu Val Ala Gln Arg Thr Ala Asp Ala Cys Asn Glu Gly
    370                 375                 380                 
Val Lys Ala Ala Trp Ser Leu Lys Glu Leu His Thr His Gln Leu Cys
385                 390                 395                 400 
Pro Arg Ser Ser Asp Tyr Arg Asn Met Ile Ile His Ala Ala Thr Pro
                405                 410                 415     
Val Asp Leu Leu Gly Ala Leu Asn Leu Cys Leu Pro Leu Met Gln Lys
            420                 425                 430         
Phe Pro Lys Gln Val Met Val Arg Ile Phe Ser Thr Asn Gln Gly Gly
        435                 440                 445             
Phe Met Leu Pro Ile Tyr Glu Thr Ala Ala Lys Ala Tyr Ala Val Gly
    450                 455                 460                 
Gln Phe Glu Gln Pro Thr Glu Thr Pro Pro Glu Asp Leu Asp Thr Leu
465                 470                 475                 480 
Ser Leu Ala Ile Glu Ala Ala Ile Gln Asp Leu Arg Asn Lys Ser Gln
                485                 490                 495     


<210> 19
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized sequence encoding mIE2(H2A)

<400> 19
atgggcgaca tcctggccca ggctgtgaac catgctggca ttgactcctc ctccacaggc 60
cccaccctga ccacccactc ctgctctgtc tcctctgccc ccctgaacaa gcccaccccc 120
acctctgtgg ctgtgaccaa cacccccctg cctggcgcct ctgccacccc tgagctgtcc 180
ccctcttctg gtccccggaa gaccacccgg ccattcaagg tgatcatcaa gccccctgtg 240
ccccctgccc ccatcatgct gcccctgatc aagcaggagg acatcaagcc tgagcctgac 300
ttcaccatcc agtaccggaa caagatcatt gacacagctg gctgcattgt gatctctgac 360
tctgaggagg agcagggcga ggaggtggag acccggggcg ccacagcctc ctccccatcc 420
acaggctctg gcaccccccg ggtgacctcc cccacccatc ccctgtccca gatgaaccat 480
ccccccctgc ctgaccccct gggccggcct gatgaggact cctcctcctc ctcctcctcc 540
tcctgctcct ctgcctctga ctctgagtct gagtctgagg agatgaagtg ctcctctggc 600
ggcggcgcct ctgtgacctc ctcccatcat ggccggggcg gctttggcgg cgctgcctcc 660
tcctccctgc tgtcctgtgg ccatcagtcc tctggcggcg cctccacagg cccccggtct 720
tctggttcca agcggatctc tgagctggac aatgagaagg tgcggaacat catgaaggac 780
aagaacaccc cattctgcac ccccaatgtg cagacccggc ggggccgggt gaagattgat 840
gaggtctccc ggatgttccg gaacaccaac cggtccctgg agtacaagaa cctgccattc 900
accatcccat ccatgcatca ggtgctggat gaggccatca aggcctgcaa gaccatgcag 960
gtgaacaaca agggcatcca gatcatctac acccggaacc atgaggtgaa gtctgaggtg 1020
gatgctgtgc ggtgccggct gggcaccatg tgcaacctgg ccctgtccac cccattcctg 1080
atggaggcca ccatgcctgt gacagccccc cctgaggtgg cccagcggac agctgatgcc 1140
tgcaatgagg gcgtgaaggc tgcctggtcc ctgaaggagc tgcacaccca tcagctgtgc 1200
ccccggtcct ctgactaccg gaacatgatc atccatgctg ccacccctgt ggacctgctg 1260
ggcgccctga acctgtgcct gcccctgatg cagaagttcc ccaagcaggt gatggtgcgg 1320
atcttctcca ccaaccaggg cggcttcatg ctgcccatct atgagacagc tgccaaggcc 1380
tatgctgtgg gccagtttga gcagcccaca gagacccccc ctgaggacct ggacaccctg 1440
tccctggcca ttgaggctgc catccaggac ctgcggaaca agtcccag              1488

<210> 20
<211> 1455
<212> PRT
<213> Artificial Sequence

<220> 
<223> mpp65-linker-mIE1-linker-mIE2 fusion protein (P12)

<400> 20
Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly
 1               5                  10                  15      
Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr
            20                  25                  30          
Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val
        35                  40                  45              
Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp
    50                  55                  60                  
Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr
65                  70                  75                  80  
Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Val His Asn
                85                  90                  95      
Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr
            100                 105                 110         
Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val
        115                 120                 125             
His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His Leu Pro Val
    130                 135                 140                 
Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg
145                 150                 155                 160 
Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn Gln Trp Lys
                165                 170                 175     
Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro Thr Lys Asp
            180                 185                 190         
Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val Cys Ser Met
        195                 200                 205             
Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr Val
    210                 215                 220                 
Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser Gly Lys Leu
225                 230                 235                 240 
Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp Leu Thr Met
                245                 250                 255     
Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe
            260                 265                 270         
Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly Lys Ile Ser
        275                 280                 285             
His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu
    290                 295                 300                 
Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly Asn Leu Leu
305                 310                 315                 320 
Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile Arg Glu Thr
                325                 330                 335     
Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp
            340                 345                 350         
Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Pro Thr
        355                 360                 365             
Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr Arg His Thr
    370                 375                 380                 
Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp Asp Val Trp
385                 390                 395                 400 
Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr Glu Gly Gly
                405                 410                 415     
Thr Pro Gly Val Thr Gly Gly Gly Ala Met Ala Gly Ala Ser Thr Ser
            420                 425                 430         
Ala Gly Arg Gly Arg Lys Ser Ala Ser Ser Ala Thr Ala Cys Thr Ser
        435                 440                 445             
Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr Val Ala Pro
    450                 455                 460                 
Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His Asn Pro Ala
465                 470                 475                 480 
Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu
                485                 490                 495     
Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr Gln Glu
            500                 505                 510         
Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu
        515                 520                 525             
Gly Val Trp Gln Pro Ala Ala Gly Gly Ser Gly Gly Pro Glu Lys Asp
    530                 535                 540                 
Val Leu Ala Glu Leu Val Lys Gln Ile Lys Val Arg Val Asp Met Val
545                 550                 555                 560 
Arg His Arg Ile Lys Glu His Met Leu Lys Lys Tyr Thr Gln Thr Glu
                565                 570                 575     
Glu Lys Phe Thr Gly Ala Phe Asn Met Met Gly Gly Cys Leu Gln Asn
            580                 585                 590         
Ala Leu Asp Ile Leu Asp Lys Val His Glu Pro Phe Glu Glu Met Lys
        595                 600                 605             
Cys Ile Gly Leu Thr Met Gln Ser Met Tyr Glu Asn Tyr Ile Val Pro
    610                 615                 620                 
Glu Asp Lys Arg Glu Met Trp Met Ala Cys Ile Lys Glu Leu His Asp
625                 630                 635                 640 
Val Ser Lys Gly Ala Ala Asn Lys Leu Gly Gly Ala Leu Gln Ala Lys
                645                 650                 655     
Ala Arg Ala Lys Lys Asp Glu Leu Arg Arg Lys Met Met Tyr Met Cys
            660                 665                 670         
Tyr Arg Asn Ile Glu Phe Phe Thr Lys Asn Ser Ala Phe Pro Lys Thr
        675                 680                 685             
Thr Asn Gly Cys Ser Gln Ala Met Ala Ala Leu Gln Asn Leu Pro Gln
    690                 695                 700                 
Cys Ser Pro Asp Glu Ile Met Ala Tyr Ala Gln Lys Ile Phe Lys Ile
705                 710                 715                 720 
Leu Asp Glu Glu Arg Asp Lys Val Leu Thr His Ile Asp His Ile Phe
                725                 730                 735     
Met Asp Ile Leu Thr Thr Cys Val Glu Thr Met Cys Asn Glu Tyr Lys
            740                 745                 750         
Val Thr Ser Asp Ala Cys Met Met Thr Met Tyr Gly Gly Ile Ser Leu
        755                 760                 765             
Leu Ser Glu Phe Cys Arg Val Leu Cys Cys Tyr Val Leu Glu Glu Thr
    770                 775                 780                 
Ser Val Met Leu Ala Lys Arg Pro Leu Ile Thr Lys Pro Glu Val Ile
785                 790                 795                 800 
Ser Val Met Gly Gly Gly Ile Glu Glu Ile Ser Met Lys Val Phe Ala
                805                 810                 815     
Gln Tyr Ile Leu Gly Ala Asp Pro Leu Arg Val Cys Ser Pro Ser Val
            820                 825                 830         
Asp Asp Leu Arg Ala Ile Ala Glu Glu Ser Asp Glu Glu Glu Ala Ile
        835                 840                 845             
Val Ala Tyr Thr Leu Ala Thr Ala Gly Val Ser Ser Ser Asp Ser Leu
    850                 855                 860                 
Val Ser Pro Pro Glu Ser Pro Val Pro Ala Thr Ile Pro Leu Ser Ser
865                 870                 875                 880 
Val Ile Val Ala Glu Asn Ser Asp Gln Glu Glu Ser Glu Gln Ser Asp
                885                 890                 895     
Glu Glu Glu Glu Glu Gly Ala Gln Glu Glu Arg Glu Asp Thr Val Ser
            900                 905                 910         
Val Lys Ser Glu Pro Val Ser Glu Ile Glu Glu Val Ala Pro Glu Glu
        915                 920                 925             
Glu Glu Asp Gly Ala Glu Glu Pro Thr Ala Ser Gly Gly Lys Ser Thr
    930                 935                 940                 
His Pro Met Val Thr Arg Ser Lys Ala Asp Gln Gly Gly Ser Gly Gly
945                 950                 955                 960 
Gly Asp Ile Leu Ala Gln Ala Val Asn His Ala Gly Ile Asp Ser Ser
                965                 970                 975     
Ser Thr Gly Pro Thr Leu Thr Thr His Ser Cys Ser Val Ser Ser Ala
            980                 985                 990         
Pro Leu Asn Lys Pro Thr Pro Thr Ser Val Ala Val Thr Asn Thr Pro
        995                 1000                1005            
Leu Pro Gly Ala Ser Ala Thr Pro Glu Leu Ser Pro Ser Ser Gly Pro
    1010                1015                1020                
Arg Lys Thr Thr Arg Pro Phe Lys Val Ile Ile Lys Pro Pro Val Pro
1025                1030                1035               1040 
Pro Ala Pro Ile Met Leu Pro Leu Ile Lys Gln Glu Asp Ile Lys Pro
                1045                1050                1055    
Glu Pro Asp Phe Thr Ile Gln Tyr Arg Asn Lys Ile Ile Asp Thr Ala
            1060                1065                1070        
Gly Cys Ile Val Ile Ser Asp Ser Glu Glu Glu Gln Gly Glu Glu Val
        1075                1080                1085            
Glu Thr Arg Gly Ala Thr Ala Ser Ser Pro Ser Thr Gly Ser Gly Thr
    1090                1095                1100                
Pro Arg Val Thr Ser Pro Thr His Pro Leu Ser Gln Met Asn His Pro
1105                1110                1115               1120 
Pro Leu Pro Asp Pro Leu Gly Arg Pro Asp Glu Asp Ser Ser Ser Ser
                1125                1130                1135    
Ser Ser Ser Ser Cys Ser Ser Ala Ser Asp Ser Glu Ser Glu Ser Glu
            1140                1145                1150        
Glu Met Lys Cys Ser Ser Gly Gly Gly Ala Ser Val Thr Ser Ser His
        1155                1160                1165            
His Gly Arg Gly Gly Phe Gly Gly Ala Ala Ser Ser Ser Leu Leu Ser
    1170                1175                1180                
Cys Gly His Gln Ser Ser Gly Gly Ala Ser Thr Gly Pro Arg Ser Ser
1185                1190                1195               1200 
Gly Ser Lys Arg Ile Ser Glu Leu Asp Asn Glu Lys Val Arg Asn Ile
                1205                1210                1215    
Met Lys Asp Lys Asn Thr Pro Phe Cys Thr Pro Asn Val Gln Thr Arg
            1220                1225                1230        
Arg Gly Arg Val Lys Ile Asp Glu Val Ser Arg Met Phe Arg Asn Thr
        1235                1240                1245            
Asn Arg Ser Leu Glu Tyr Lys Asn Leu Pro Phe Thr Ile Pro Ser Met
    1250                1255                1260                
His Gln Val Leu Asp Glu Ala Ile Lys Ala Cys Lys Thr Met Gln Val
1265                1270                1275               1280 
Asn Asn Lys Gly Ile Gln Ile Ile Tyr Thr Arg Asn His Glu Val Lys
                1285                1290                1295    
Ser Glu Val Asp Ala Val Arg Cys Arg Leu Gly Thr Met Cys Asn Leu
            1300                1305                1310        
Ala Leu Ser Thr Pro Phe Leu Met Glu His Thr Met Pro Val Thr His
        1315                1320                1325            
Pro Pro Glu Val Ala Gln Arg Thr Ala Asp Ala Cys Asn Glu Gly Val
    1330                1335                1340                
Lys Ala Ala Trp Ser Leu Lys Glu Leu His Thr His Gln Leu Cys Pro
1345                1350                1355               1360 
Arg Ser Ser Asp Tyr Arg Asn Met Ile Ile His Ala Ala Thr Pro Val
                1365                1370                1375    
Asp Leu Leu Gly Ala Leu Asn Leu Cys Leu Pro Leu Met Gln Lys Phe
            1380                1385                1390        
Pro Lys Gln Val Met Val Arg Ile Phe Ser Thr Asn Gln Gly Gly Phe
        1395                1400                1405            
Met Leu Pro Ile Tyr Glu Thr Ala Ala Lys Ala Tyr Ala Val Gly Gln
    1410                1415                1420                
Phe Glu Gln Pro Thr Glu Thr Pro Pro Glu Asp Leu Asp Thr Leu Ser
1425                1430                1435               1440 
Leu Ala Ile Glu Ala Ala Ile Gln Asp Leu Arg Asn Lys Ser Gln
                1445                1450                1455


<210> 21
<211> 4368
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence encoding P12

<400> 21
atggagtctc gtggtcgtcg gtgccctgag atgatctctg tgctgggacc catctctggc 60
catgtgctga aggctgtctt ctctcgggga gacacccctg tgctgcctca tgagacccgg 120
ctgcttcaga caggcatcca tgtgcgggtc tcccagccat ccctgatcct ggtctcccag 180
tacacccctg actctacccc atgccatcgg ggtgacaacc agcttcaggt gcagcacacc 240
tacttcacag gctctgaggt ggagaatgtc tctgtgaatg ttcacaaccc tacaggccgg 300
tccatctgcc catcccagga gcccatgtcc atctatgtct atgccctgcc tctgaagatg 360
ctgaacatcc catccatcaa tgtgcatcac tacccatctg ctgctgagcg gaagcatcgg 420
catctgcctg tggctgatgc tgtgatccat gcctctggca agcagatgtg gcaggctcgg 480
ctgacagtct ctggcctggc ctggactcgg cagcagaacc agtggaagga gcctgatgtc 540
tactacacct ctgcctttgt cttccccacc aaggatgtgg ctctgcggca tgtggtctgt 600
gctcatgagc tggtctgctc tatggagaac actcgggcca ccaagatgca ggtgattggt 660
gaccagtatg tgaaggtcta cctggagtcc ttctgtgagg atgtgccatc tggcaagctg 720
ttcatgcatg tgaccctggg ctctgatgtg gaggaggacc tgaccatgac tcggaaccct 780
cagccattca tgcggcctca tgagcggaat ggcttcacag tgctgtgccc taagaacatg 840
atcatcaagc ctggcaagat cagccacatc atgctggatg tggccttcac ctcccatgag 900
cactttggcc tgctgtgccc caagtccatc cctggcctgt ccatctctgg caacctgctg 960
atgaatggcc agcagatatt cctggaggtg caggccatcc gggagacagt ggagctgcgg 1020
cagtatgacc ctgtggctgc tctgttcttc tttgacattg acctgctact gcagcggggc 1080
cctcagtact ctgagcatcc caccttcacc tcccagtacc gtatccaggg caagctggag 1140
taccggcaca cctgggaccg gcatgatgag ggtgctgccc agggtgatga tgatgtctgg 1200
acctctggct ctgactctga tgaggagctg gtgaccacag agggtggcac ccctggtgtg 1260
acaggtggag gtgctatggc tggtgcctcc acctctgctg gtcggggtcg gaagtctgcc 1320
tcctctgcca cagcttgcac ctctggtgtg atgactcgtg gtcggctgaa ggctgagtcc 1380
acagtggctc ctgaggagga cacagatgag gactctgaca atgagatcca caaccctgct 1440
gtcttcacct ggcctccatg gcaggctggc atcctggctc ggaacctggt gcctatggtg 1500
gccacagtgc agggtcagaa cctgaagtac caggagttct tctgggatgc caatgacatc 1560
taccggatct ttgctgagct ggagggtgtc tggcagcctg ctgccggtgg atccggtgga 1620
cctgagaagg atgtgctggc tgagctggtg aagcagatca aggtgcgggt ggacatggtg 1680
cggcatcgga tcaaggagca catgctgaag aagtacaccc agacagagga gaagttcaca 1740
ggcgccttca acatgatggg tggctgcctg cagaatgccc tggacatcct ggacaaggtg 1800
catgagccat ttgaggagat gaagtgcatt ggcctgacca tgcagtccat gtatgagaac 1860
tacattgtgc ctgaggacaa gcgggagatg tggatggcct gcatcaagga gctgcatgat 1920
gtctccaagg gcgctgccaa caagctgggc ggtgccctgc aggccaaggc ccgggccaag 1980
aaggatgagc tgcggcggaa gatgatgtac atgtgctacc ggaacattga gttcttcacc 2040
aagaactctg ccttccccaa gaccaccaat ggctgctccc aggccatggc tgccctgcag 2100
aacctgcccc agtgctcccc tgatgagatc atggcctatg cccagaagat attcaagatc 2160
ctggatgagg agcgggacaa ggtgctgacc cacattgacc acatcttcat ggacatcctg 2220
accacctgtg tggagaccat gtgcaatgag tacaaggtga cctctgatgc ctgcatgatg 2280
accatgtatg gcggcatctc cctgctgtct gagttctgcc gggtgctgtg ctgctatgtg 2340
ctggaggaga cctctgtgat gctggccaag cggcccctga tcaccaagcc tgaggtgatc 2400
tctgtgatgg gtggcggtat tgaggagatc agcatgaagg tctttgccca gtacatcctg 2460
ggcgctgacc ctctgcgggt ctgctcccca tctgtggatg acctgcgggc cattgctgag 2520
gagtctgatg aggaggaggc cattgtggcc tacaccctgg ccacagctgg cgtctcctcc 2580
tctgactccc tggtctcccc ccctgagtcc cctgtgcctg ccaccatccc cctgtcctct 2640
gtgattgtgg ctgagaactc tgaccaggag gagtctgagc agtctgatga ggaggaggag 2700
gagggtgccc aggaggagcg ggaggacaca gtctctgtga agtctgagcc tgtctctgag 2760
attgaggagg tggcccctga ggaggaggag gatggcgctg aggagcccac agcctctggc 2820
ggcaagtcca cccatcccat ggtgacccgg tccaaggctg accagggtgg tagtggagga 2880
ggcgacatcc tggcccaggc tgtgaaccat gctggcattg actcctcctc cacaggcccc 2940
accctgacca cccactcctg ctctgtctcc tctgcccccc tgaacaagcc cacccccacc 3000
tctgtggctg tgaccaacac ccccctgcct ggcgcctctg ccacccctga gctgtccccc 3060
tcttctggtc cccggaagac cacccggcca ttcaaggtga tcatcaagcc ccctgtgccc 3120
cctgccccca tcatgctgcc cctgatcaag caggaggaca tcaagcctga gcctgacttc 3180
accatccagt accggaacaa gatcattgac acagctggct gcattgtgat ctctgactct 3240
gaggaggagc agggcgagga ggtggagacc cggggcgcca cagcctcctc cccatccaca 3300
ggctctggca ccccccgggt gacctccccc acccatcccc tgtcccagat gaaccatccc 3360
cccctgcctg accccctggg ccggcctgat gaggactcct cctcctcctc ctcctcctcc 3420
tgctcctctg cctctgactc tgagtctgag tctgaggaga tgaagtgctc ctctggcggc 3480
ggcgcctctg tgacctcctc ccatcatggc cggggcggct ttggcggcgc tgcctcctcc 3540
tccctgctgt cctgtggcca tcagtcctct ggcggcgcct ccacaggccc ccggtcttct 3600
ggttccaagc ggatctctga gctggacaat gagaaggtgc ggaacatcat gaaggacaag 3660
aacaccccat tctgcacccc caatgtgcag acccggcggg gccgggtgaa gattgatgag 3720
gtctcccgga tgttccggaa caccaaccgg tccctggagt acaagaacct gccattcacc 3780
atcccatcca tgcatcaggt gctggatgag gccatcaagg cctgcaagac catgcaggtg 3840
aacaacaagg gcatccagat catctacacc cggaaccatg aggtgaagtc tgaggtggat 3900
gctgtgcggt gccggctggg caccatgtgc aacctggccc tgtccacccc attcctgatg 3960
gagcacacca tgcctgtgac ccatccccct gaggtggccc agcggacagc tgatgcctgc 4020
aatgagggcg tgaaggctgc ctggtccctg aaggagctgc acacccatca gctgtgcccc 4080
cggtcctctg actaccggaa catgatcatc catgctgcca cccctgtgga cctgctgggc 4140
gccctgaacc tgtgcctgcc cctgatgcag aagttcccca agcaggtgat ggtgcggatc 4200
ttctccacca accagggcgg cttcatgctg cccatctatg agacagctgc caaggcctat 4260
gctgtgggcc agtttgagca gcccacagag accccccctg aggacctgga caccctgtcc 4320
ctggccattg aggctgccat ccaggacctg cggaacaagt cccagtaa              4368

<210> 22
<211> 1455
<212> PRT
<213> Artificial Sequence

<220> 
<223> mpp65-linker-mIE2-linker-mIE1 fusion protein (P21)

<400> 22
Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly
 1               5                  10                  15      
Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr
            20                  25                  30          
Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val
        35                  40                  45              
Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp
    50                  55                  60                  
Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr
65                  70                  75                  80  
Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Val His Asn
                85                  90                  95      
Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr
            100                 105                 110         
Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val
        115                 120                 125             
His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His Leu Pro Val
    130                 135                 140                 
Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg
145                 150                 155                 160 
Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn Gln Trp Lys
                165                 170                 175     
Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro Thr Lys Asp
            180                 185                 190         
Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val Cys Ser Met
        195                 200                 205             
Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr Val
    210                 215                 220                 
Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser Gly Lys Leu
225                 230                 235                 240 
Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp Leu Thr Met
                245                 250                 255     
Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe
            260                 265                 270         
Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly Lys Ile Ser
        275                 280                 285             
His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu
    290                 295                 300                 
Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly Asn Leu Leu
305                 310                 315                 320 
Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile Arg Glu Thr
                325                 330                 335     
Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp
            340                 345                 350         
Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Pro Thr
        355                 360                 365             
Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr Arg His Thr
    370                 375                 380                 
Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp Asp Val Trp
385                 390                 395                 400 
Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr Glu Gly Gly
                405                 410                 415     
Thr Pro Gly Val Thr Gly Gly Gly Ala Met Ala Gly Ala Ser Thr Ser
            420                 425                 430         
Ala Gly Arg Gly Arg Lys Ser Ala Ser Ser Ala Thr Ala Cys Thr Ser
        435                 440                 445             
Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr Val Ala Pro
    450                 455                 460                 
Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His Asn Pro Ala
465                 470                 475                 480 
Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu
                485                 490                 495     
Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr Gln Glu
            500                 505                 510         
Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu
        515                 520                 525             
Gly Val Trp Gln Pro Ala Ala Gly Gly Ser Gly Gly Gly Asp Ile Leu
    530                 535                 540                 
Ala Gln Ala Val Asn His Ala Gly Ile Asp Ser Ser Ser Thr Gly Pro
545                 550                 555                 560 
Thr Leu Thr Thr His Ser Cys Ser Val Ser Ser Ala Pro Leu Asn Lys
                565                 570                 575     
Pro Thr Pro Thr Ser Val Ala Val Thr Asn Thr Pro Leu Pro Gly Ala
            580                 585                 590         
Ser Ala Thr Pro Glu Leu Ser Pro Ser Ser Gly Pro Arg Lys Thr Thr
        595                 600                 605             
Arg Pro Phe Lys Val Ile Ile Lys Pro Pro Val Pro Pro Ala Pro Ile
    610                 615                 620                 
Met Leu Pro Leu Ile Lys Gln Glu Asp Ile Lys Pro Glu Pro Asp Phe
625                 630                 635                 640 
Thr Ile Gln Tyr Arg Asn Lys Ile Ile Asp Thr Ala Gly Cys Ile Val
                645                 650                 655     
Ile Ser Asp Ser Glu Glu Glu Gln Gly Glu Glu Val Glu Thr Arg Gly
            660                 665                 670         
Ala Thr Ala Ser Ser Pro Ser Thr Gly Ser Gly Thr Pro Arg Val Thr
        675                 680                 685             
Ser Pro Thr His Pro Leu Ser Gln Met Asn His Pro Pro Leu Pro Asp
    690                 695                 700                 
Pro Leu Gly Arg Pro Asp Glu Asp Ser Ser Ser Ser Ser Ser Ser Ser
705                 710                 715                 720 
Cys Ser Ser Ala Ser Asp Ser Glu Ser Glu Ser Glu Glu Met Lys Cys
                725                 730                 735     
Ser Ser Gly Gly Gly Ala Ser Val Thr Ser Ser His His Gly Arg Gly
            740                 745                 750         
Gly Phe Gly Gly Ala Ala Ser Ser Ser Leu Leu Ser Cys Gly His Gln
        755                 760                 765             
Ser Ser Gly Gly Ala Ser Thr Gly Pro Arg Ser Ser Gly Ser Lys Arg
    770                 775                 780                 
Ile Ser Glu Leu Asp Asn Glu Lys Val Arg Asn Ile Met Lys Asp Lys
785                 790                 795                 800 
Asn Thr Pro Phe Cys Thr Pro Asn Val Gln Thr Arg Arg Gly Arg Val
                805                 810                 815     
Lys Ile Asp Glu Val Ser Arg Met Phe Arg Asn Thr Asn Arg Ser Leu
            820                 825                 830         
Glu Tyr Lys Asn Leu Pro Phe Thr Ile Pro Ser Met His Gln Val Leu
        835                 840                 845             
Asp Glu Ala Ile Lys Ala Cys Lys Thr Met Gln Val Asn Asn Lys Gly
    850                 855                 860                 
Ile Gln Ile Ile Tyr Thr Arg Asn His Glu Val Lys Ser Glu Val Asp
865                 870                 875                 880 
Ala Val Arg Cys Arg Leu Gly Thr Met Cys Asn Leu Ala Leu Ser Thr
                885                 890                 895     
Pro Phe Leu Met Glu His Thr Met Pro Val Thr His Pro Pro Glu Val
            900                 905                 910         
Ala Gln Arg Thr Ala Asp Ala Cys Asn Glu Gly Val Lys Ala Ala Trp
        915                 920                 925             
Ser Leu Lys Glu Leu His Thr His Gln Leu Cys Pro Arg Ser Ser Asp
    930                 935                 940                 
Tyr Arg Asn Met Ile Ile His Ala Ala Thr Pro Val Asp Leu Leu Gly
945                 950                 955                 960 
Ala Leu Asn Leu Cys Leu Pro Leu Met Gln Lys Phe Pro Lys Gln Val
                965                 970                 975     
Met Val Arg Ile Phe Ser Thr Asn Gln Gly Gly Phe Met Leu Pro Ile
            980                 985                 990         
Tyr Glu Thr Ala Ala Lys Ala Tyr Ala Val Gly Gln Phe Glu Gln Pro
        995                 1000                1005            
Thr Glu Thr Pro Pro Glu Asp Leu Asp Thr Leu Ser Leu Ala Ile Glu
    1010                1015                1020                
Ala Ala Ile Gln Asp Leu Arg Asn Lys Ser Gln Gly Gly Ser Gly Gly
1025                1030                1035               1040 
Pro Glu Lys Asp Val Leu Ala Glu Leu Val Lys Gln Ile Lys Val Arg
                1045                1050                1055    
Val Asp Met Val Arg His Arg Ile Lys Glu His Met Leu Lys Lys Tyr
            1060                1065                1070        
Thr Gln Thr Glu Glu Lys Phe Thr Gly Ala Phe Asn Met Met Gly Gly
        1075                1080                1085            
Cys Leu Gln Asn Ala Leu Asp Ile Leu Asp Lys Val His Glu Pro Phe
    1090                1095                1100                
Glu Glu Met Lys Cys Ile Gly Leu Thr Met Gln Ser Met Tyr Glu Asn
1105                1110                1115               1120 
Tyr Ile Val Pro Glu Asp Lys Arg Glu Met Trp Met Ala Cys Ile Lys
                1125                1130                1135    
Glu Leu His Asp Val Ser Lys Gly Ala Ala Asn Lys Leu Gly Gly Ala
            1140                1145                1150        
Leu Gln Ala Lys Ala Arg Ala Lys Lys Asp Glu Leu Arg Arg Lys Met
        1155                1160                1165            
Met Tyr Met Cys Tyr Arg Asn Ile Glu Phe Phe Thr Lys Asn Ser Ala
    1170                1175                1180                
Phe Pro Lys Thr Thr Asn Gly Cys Ser Gln Ala Met Ala Ala Leu Gln
1185                1190                1195               1200 
Asn Leu Pro Gln Cys Ser Pro Asp Glu Ile Met Ala Tyr Ala Gln Lys
                1205                1210                1215    
Ile Phe Lys Ile Leu Asp Glu Glu Arg Asp Lys Val Leu Thr His Ile
            1220                1225                1230        
Asp His Ile Phe Met Asp Ile Leu Thr Thr Cys Val Glu Thr Met Cys
        1235                1240                1245            
Asn Glu Tyr Lys Val Thr Ser Asp Ala Cys Met Met Thr Met Tyr Gly
    1250                1255                1260                
Gly Ile Ser Leu Leu Ser Glu Phe Cys Arg Val Leu Cys Cys Tyr Val
1265                1270                1275               1280 
Leu Glu Glu Thr Ser Val Met Leu Ala Lys Arg Pro Leu Ile Thr Lys
                1285                1290                1295    
Pro Glu Val Ile Ser Val Met Gly Gly Gly Ile Glu Glu Ile Ser Met
            1300                1305                1310        
Lys Val Phe Ala Gln Tyr Ile Leu Gly Ala Asp Pro Leu Arg Val Cys
        1315                1320                1325            
Ser Pro Ser Val Asp Asp Leu Arg Ala Ile Ala Glu Glu Ser Asp Glu
    1330                1335                1340                
Glu Glu Ala Ile Val Ala Tyr Thr Leu Ala Thr Ala Gly Val Ser Ser
1345                1350                1355               1360 
Ser Asp Ser Leu Val Ser Pro Pro Glu Ser Pro Val Pro Ala Thr Ile
                1365                1370                1375    
Pro Leu Ser Ser Val Ile Val Ala Glu Asn Ser Asp Gln Glu Glu Ser
            1380                1385                1390        
Glu Gln Ser Asp Glu Glu Glu Glu Glu Gly Ala Gln Glu Glu Arg Glu
        1395                1400                1405            
Asp Thr Val Ser Val Lys Ser Glu Pro Val Ser Glu Ile Glu Glu Val
    1410                1415                1420                
Ala Pro Glu Glu Glu Glu Asp Gly Ala Glu Glu Pro Thr Ala Ser Gly
1425                1430                1435               1440 
Gly Lys Ser Thr His Pro Met Val Thr Arg Ser Lys Ala Asp Gln
                1445                1450                1455


<210> 23
<211> 4368
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence encoding P21

<400> 23
atggagtctc gtggtcgtcg gtgccctgag atgatctctg tgctgggacc catctctggc 60
catgtgctga aggctgtctt ctctcgggga gacacccctg tgctgcctca tgagacccgg 120
ctgcttcaga caggcatcca tgtgcgggtc tcccagccat ccctgatcct ggtctcccag 180
tacacccctg actctacccc atgccatcgg ggtgacaacc agcttcaggt gcagcacacc 240
tacttcacag gctctgaggt ggagaatgtc tctgtgaatg ttcacaaccc tacaggccgg 300
tccatctgcc catcccagga gcccatgtcc atctatgtct atgccctgcc tctgaagatg 360
ctgaacatcc catccatcaa tgtgcatcac tacccatctg ctgctgagcg gaagcatcgg 420
catctgcctg tggctgatgc tgtgatccat gcctctggca agcagatgtg gcaggctcgg 480
ctgacagtct ctggcctggc ctggactcgg cagcagaacc agtggaagga gcctgatgtc 540
tactacacct ctgcctttgt cttccccacc aaggatgtgg ctctgcggca tgtggtctgt 600
gctcatgagc tggtctgctc tatggagaac actcgggcca ccaagatgca ggtgattggt 660
gaccagtatg tgaaggtcta cctggagtcc ttctgtgagg atgtgccatc tggcaagctg 720
ttcatgcatg tgaccctggg ctctgatgtg gaggaggacc tgaccatgac tcggaaccct 780
cagccattca tgcggcctca tgagcggaat ggcttcacag tgctgtgccc taagaacatg 840
atcatcaagc ctggcaagat cagccacatc atgctggatg tggccttcac ctcccatgag 900
cactttggcc tgctgtgccc caagtccatc cctggcctgt ccatctctgg caacctgctg 960
atgaatggcc agcagatatt cctggaggtg caggccatcc gggagacagt ggagctgcgg 1020
cagtatgacc ctgtggctgc tctgttcttc tttgacattg acctgctact gcagcggggc 1080
cctcagtact ctgagcatcc caccttcacc tcccagtacc gtatccaggg caagctggag 1140
taccggcaca cctgggaccg gcatgatgag ggtgctgccc agggtgatga tgatgtctgg 1200
acctctggct ctgactctga tgaggagctg gtgaccacag agggtggcac ccctggtgtg 1260
acaggtggag gtgctatggc tggtgcctcc acctctgctg gtcggggtcg gaagtctgcc 1320
tcctctgcca cagcttgcac ctctggtgtg atgactcgtg gtcggctgaa ggctgagtcc 1380
acagtggctc ctgaggagga cacagatgag gactctgaca atgagatcca caaccctgct 1440
gtcttcacct ggcctccatg gcaggctggc atcctggctc ggaacctggt gcctatggtg 1500
gccacagtgc agggtcagaa cctgaagtac caggagttct tctgggatgc caatgacatc 1560
taccggatct ttgctgagct ggagggtgtc tggcagcctg ctgccggtgg atccggtgga 1620
ggcgacatcc tggcccaggc tgtgaaccat gctggcattg actcctcctc cacaggcccc 1680
accctgacca cccactcctg ctctgtctcc tctgcccccc tgaacaagcc cacccccacc 1740
tctgtggctg tgaccaacac ccccctgcct ggcgcctctg ccacccctga gctgtccccc 1800
tcttctggtc cccggaagac cacccggcca ttcaaggtga tcatcaagcc ccctgtgccc 1860
cctgccccca tcatgctgcc cctgatcaag caggaggaca tcaagcctga gcctgacttc 1920
accatccagt accggaacaa gatcattgac acagctggct gcattgtgat ctctgactct 1980
gaggaggagc agggcgagga ggtggagacc cggggcgcca cagcctcctc cccatccaca 2040
ggctctggca ccccccgggt gacctccccc acccatcccc tgtcccagat gaaccatccc 2100
cccctgcctg accccctggg ccggcctgat gaggactcct cctcctcctc ctcctcctcc 2160
tgctcctctg cctctgactc tgagtctgag tctgaggaga tgaagtgctc ctctggcggc 2220
ggcgcctctg tgacctcctc ccatcatggc cggggcggct ttggcggcgc tgcctcctcc 2280
tccctgctgt cctgtggcca tcagtcctct ggcggcgcct ccacaggccc ccggtcttct 2340
ggttccaagc ggatctctga gctggacaat gagaaggtgc ggaacatcat gaaggacaag 2400
aacaccccat tctgcacccc caatgtgcag acccggcggg gccgggtgaa gattgatgag 2460
gtctcccgga tgttccggaa caccaaccgg tccctggagt acaagaacct gccattcacc 2520
atcccatcca tgcatcaggt gctggatgag gccatcaagg cctgcaagac catgcaggtg 2580
aacaacaagg gcatccagat catctacacc cggaaccatg aggtgaagtc tgaggtggat 2640
gctgtgcggt gccggctggg caccatgtgc aacctggccc tgtccacccc attcctgatg 2700
gagcacacca tgcctgtgac ccatccccct gaggtggccc agcggacagc tgatgcctgc 2760
aatgagggcg tgaaggctgc ctggtccctg aaggagctgc acacccatca gctgtgcccc 2820
cggtcctctg actaccggaa catgatcatc catgctgcca cccctgtgga cctgctgggc 2880
gccctgaacc tgtgcctgcc cctgatgcag aagttcccca agcaggtgat ggtgcggatc 2940
ttctccacca accagggcgg cttcatgctg cccatctatg agacagctgc caaggcctat 3000
gctgtgggcc agtttgagca gcccacagag accccccctg aggacctgga caccctgtcc 3060
ctggccattg aggctgccat ccaggacctg cggaacaagt cccagggtgg tagtggagga 3120
cctgagaagg atgtgctggc tgagctggtg aagcagatca aggtgcgggt ggacatggtg 3180
cggcatcgga tcaaggagca catgctgaag aagtacaccc agacagagga gaagttcaca 3240
ggcgccttca acatgatggg tggctgcctg cagaatgccc tggacatcct ggacaaggtg 3300
catgagccat ttgaggagat gaagtgcatt ggcctgacca tgcagtccat gtatgagaac 3360
tacattgtgc ctgaggacaa gcgggagatg tggatggcct gcatcaagga gctgcatgat 3420
gtctccaagg gcgctgccaa caagctgggc ggtgccctgc aggccaaggc ccgggccaag 3480
aaggatgagc tgcggcggaa gatgatgtac atgtgctacc ggaacattga gttcttcacc 3540
aagaactctg ccttccccaa gaccaccaat ggctgctccc aggccatggc tgccctgcag 3600
aacctgcccc agtgctcccc tgatgagatc atggcctatg cccagaagat attcaagatc 3660
ctggatgagg agcgggacaa ggtgctgacc cacattgacc acatcttcat ggacatcctg 3720
accacctgtg tggagaccat gtgcaatgag tacaaggtga cctctgatgc ctgcatgatg 3780
accatgtatg gcggcatctc cctgctgtct gagttctgcc gggtgctgtg ctgctatgtg 3840
ctggaggaga cctctgtgat gctggccaag cggcccctga tcaccaagcc tgaggtgatc 3900
tctgtgatgg gtggcggtat tgaggagatc agcatgaagg tctttgccca gtacatcctg 3960
ggcgctgacc ctctgcgggt ctgctcccca tctgtggatg acctgcgggc cattgctgag 4020
gagtctgatg aggaggaggc cattgtggcc tacaccctgg ccacagctgg cgtctcctcc 4080
tctgactccc tggtctcccc ccctgagtcc cctgtgcctg ccaccatccc cctgtcctct 4140
gtgattgtgg ctgagaactc tgaccaggag gagtctgagc agtctgatga ggaggaggag 4200
gagggtgccc aggaggagcg ggaggacaca gtctctgtga agtctgagcc tgtctctgag 4260
attgaggagg tggcccctga ggaggaggag gatggcgctg aggagcccac agcctctggc 4320
ggcaagtcca cccatcccat ggtgacccgg tccaaggctg accagtaa              4368

<210> 24
<211> 1455
<212> PRT
<213> Artificial Sequence

<220> 
<223> mIE2-linker-mpp65-linker-mIE1 fusion protein (2P1)

<400> 24
Met Gly Asp Ile Leu Ala Gln Ala Val Asn His Ala Gly Ile Asp Ser
 1               5                  10                  15      
Ser Ser Thr Gly Pro Thr Leu Thr Thr His Ser Cys Ser Val Ser Ser
            20                  25                  30          
Ala Pro Leu Asn Lys Pro Thr Pro Thr Ser Val Ala Val Thr Asn Thr
        35                  40                  45              
Pro Leu Pro Gly Ala Ser Ala Thr Pro Glu Leu Ser Pro Ser Ser Gly
    50                  55                  60                  
Pro Arg Lys Thr Thr Arg Pro Phe Lys Val Ile Ile Lys Pro Pro Val
65                  70                  75                  80  
Pro Pro Ala Pro Ile Met Leu Pro Leu Ile Lys Gln Glu Asp Ile Lys
                85                  90                  95      
Pro Glu Pro Asp Phe Thr Ile Gln Tyr Arg Asn Lys Ile Ile Asp Thr
            100                 105                 110         
Ala Gly Cys Ile Val Ile Ser Asp Ser Glu Glu Glu Gln Gly Glu Glu
        115                 120                 125             
Val Glu Thr Arg Gly Ala Thr Ala Ser Ser Pro Ser Thr Gly Ser Gly
    130                 135                 140                 
Thr Pro Arg Val Thr Ser Pro Thr His Pro Leu Ser Gln Met Asn His
145                 150                 155                 160 
Pro Pro Leu Pro Asp Pro Leu Gly Arg Pro Asp Glu Asp Ser Ser Ser
                165                 170                 175     
Ser Ser Ser Ser Ser Cys Ser Ser Ala Ser Asp Ser Glu Ser Glu Ser
            180                 185                 190         
Glu Glu Met Lys Cys Ser Ser Gly Gly Gly Ala Ser Val Thr Ser Ser
        195                 200                 205             
His His Gly Arg Gly Gly Phe Gly Gly Ala Ala Ser Ser Ser Leu Leu
    210                 215                 220                 
Ser Cys Gly His Gln Ser Ser Gly Gly Ala Ser Thr Gly Pro Arg Ser
225                 230                 235                 240 
Ser Gly Ser Lys Arg Ile Ser Glu Leu Asp Asn Glu Lys Val Arg Asn
                245                 250                 255     
Ile Met Lys Asp Lys Asn Thr Pro Phe Cys Thr Pro Asn Val Gln Thr
            260                 265                 270         
Arg Arg Gly Arg Val Lys Ile Asp Glu Val Ser Arg Met Phe Arg Asn
        275                 280                 285             
Thr Asn Arg Ser Leu Glu Tyr Lys Asn Leu Pro Phe Thr Ile Pro Ser
    290                 295                 300                 
Met His Gln Val Leu Asp Glu Ala Ile Lys Ala Cys Lys Thr Met Gln
305                 310                 315                 320 
Val Asn Asn Lys Gly Ile Gln Ile Ile Tyr Thr Arg Asn His Glu Val
                325                 330                 335     
Lys Ser Glu Val Asp Ala Val Arg Cys Arg Leu Gly Thr Met Cys Asn
            340                 345                 350         
Leu Ala Leu Ser Thr Pro Phe Leu Met Glu His Thr Met Pro Val Thr
        355                 360                 365             
His Pro Pro Glu Val Ala Gln Arg Thr Ala Asp Ala Cys Asn Glu Gly
    370                 375                 380                 
Val Lys Ala Ala Trp Ser Leu Lys Glu Leu His Thr His Gln Leu Cys
385                 390                 395                 400 
Pro Arg Ser Ser Asp Tyr Arg Asn Met Ile Ile His Ala Ala Thr Pro
                405                 410                 415     
Val Asp Leu Leu Gly Ala Leu Asn Leu Cys Leu Pro Leu Met Gln Lys
            420                 425                 430         
Phe Pro Lys Gln Val Met Val Arg Ile Phe Ser Thr Asn Gln Gly Gly
        435                 440                 445             
Phe Met Leu Pro Ile Tyr Glu Thr Ala Ala Lys Ala Tyr Ala Val Gly
    450                 455                 460                 
Gln Phe Glu Gln Pro Thr Glu Thr Pro Pro Glu Asp Leu Asp Thr Leu
465                 470                 475                 480 
Ser Leu Ala Ile Glu Ala Ala Ile Gln Asp Leu Arg Asn Lys Ser Gln
                485                 490                 495     
Gly Gly Ser Gly Gly Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile
            500                 505                 510         
Ser Val Leu Gly Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser
        515                 520                 525             
Arg Gly Asp Thr Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr
    530                 535                 540                 
Gly Ile His Val Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln
545                 550                 555                 560 
Tyr Thr Pro Asp Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln
                565                 570                 575     
Val Gln His Thr Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val
            580                 585                 590         
Asn Val His Asn Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro
        595                 600                 605             
Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro
    610                 615                 620                 
Ser Ile Asn Val His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg
625                 630                 635                 640 
His Leu Pro Val Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met
                645                 650                 655     
Trp Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln
            660                 665                 670         
Asn Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe
        675                 680                 685             
Pro Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala His Glu Leu
    690                 695                 700                 
Val Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly
705                 710                 715                 720 
Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro
                725                 730                 735     
Ser Gly Lys Leu Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu
            740                 745                 750         
Asp Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu
        755                 760                 765             
Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro
    770                 775                 780                 
Gly Lys Ile Ser His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu
785                 790                 795                 800 
His Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser
                805                 810                 815     
Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala
            820                 825                 830         
Ile Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu
        835                 840                 845             
Phe Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser
    850                 855                 860                 
Glu His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu
865                 870                 875                 880 
Tyr Arg His Thr Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp
                885                 890                 895     
Asp Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr
            900                 905                 910         
Thr Glu Gly Gly Thr Pro Gly Val Thr Gly Gly Gly Ala Met Ala Gly
        915                 920                 925             
Ala Ser Thr Ser Ala Gly Arg Gly Arg Lys Ser Ala Ser Ser Ala Thr
    930                 935                 940                 
Ala Cys Thr Ser Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser
945                 950                 955                 960 
Thr Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile
                965                 970                 975     
His Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu
            980                 985                 990         
Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu
        995                 1000                1005            
Lys Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe
    1010                1015                1020                
Ala Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gly Gly Ser Gly Gly
1025                1030                1035               1040 
Pro Glu Lys Asp Val Leu Ala Glu Leu Val Lys Gln Ile Lys Val Arg
                1045                1050                1055    
Val Asp Met Val Arg His Arg Ile Lys Glu His Met Leu Lys Lys Tyr
            1060                1065                1070        
Thr Gln Thr Glu Glu Lys Phe Thr Gly Ala Phe Asn Met Met Gly Gly
        1075                1080                1085            
Cys Leu Gln Asn Ala Leu Asp Ile Leu Asp Lys Val His Glu Pro Phe
    1090                1095                1100                
Glu Glu Met Lys Cys Ile Gly Leu Thr Met Gln Ser Met Tyr Glu Asn
1105                1110                1115               1120 
Tyr Ile Val Pro Glu Asp Lys Arg Glu Met Trp Met Ala Cys Ile Lys
                1125                1130                1135    
Glu Leu His Asp Val Ser Lys Gly Ala Ala Asn Lys Leu Gly Gly Ala
            1140                1145                1150        
Leu Gln Ala Lys Ala Arg Ala Lys Lys Asp Glu Leu Arg Arg Lys Met
        1155                1160                1165            
Met Tyr Met Cys Tyr Arg Asn Ile Glu Phe Phe Thr Lys Asn Ser Ala
    1170                1175                1180                
Phe Pro Lys Thr Thr Asn Gly Cys Ser Gln Ala Met Ala Ala Leu Gln
1185                1190                1195               1200 
Asn Leu Pro Gln Cys Ser Pro Asp Glu Ile Met Ala Tyr Ala Gln Lys
                1205                1210                1215    
Ile Phe Lys Ile Leu Asp Glu Glu Arg Asp Lys Val Leu Thr His Ile
            1220                1225                1230        
Asp His Ile Phe Met Asp Ile Leu Thr Thr Cys Val Glu Thr Met Cys
        1235                1240                1245            
Asn Glu Tyr Lys Val Thr Ser Asp Ala Cys Met Met Thr Met Tyr Gly
    1250                1255                1260                
Gly Ile Ser Leu Leu Ser Glu Phe Cys Arg Val Leu Cys Cys Tyr Val
1265                1270                1275               1280 
Leu Glu Glu Thr Ser Val Met Leu Ala Lys Arg Pro Leu Ile Thr Lys
                1285                1290                1295    
Pro Glu Val Ile Ser Val Met Gly Gly Gly Ile Glu Glu Ile Ser Met
            1300                1305                1310        
Lys Val Phe Ala Gln Tyr Ile Leu Gly Ala Asp Pro Leu Arg Val Cys
        1315                1320                1325            
Ser Pro Ser Val Asp Asp Leu Arg Ala Ile Ala Glu Glu Ser Asp Glu
    1330                1335                1340                
Glu Glu Ala Ile Val Ala Tyr Thr Leu Ala Thr Ala Gly Val Ser Ser
1345                1350                1355               1360 
Ser Asp Ser Leu Val Ser Pro Pro Glu Ser Pro Val Pro Ala Thr Ile
                1365                1370                1375    
Pro Leu Ser Ser Val Ile Val Ala Glu Asn Ser Asp Gln Glu Glu Ser
            1380                1385                1390        
Glu Gln Ser Asp Glu Glu Glu Glu Glu Gly Ala Gln Glu Glu Arg Glu
        1395                1400                1405            
Asp Thr Val Ser Val Lys Ser Glu Pro Val Ser Glu Ile Glu Glu Val
    1410                1415                1420                
Ala Pro Glu Glu Glu Glu Asp Gly Ala Glu Glu Pro Thr Ala Ser Gly
1425                1430                1435               1440 
Gly Lys Ser Thr His Pro Met Val Thr Arg Ser Lys Ala Asp Gln
                1445                1450                1455


<210> 25
<211> 4368
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence encoding 2P1

<400> 25
atgggcgaca tcctggccca ggctgtgaac catgctggca ttgactcctc ctccacaggc 60
cccaccctga ccacccactc ctgctctgtc tcctctgccc ccctgaacaa gcccaccccc 120
acctctgtgg ctgtgaccaa cacccccctg cctggcgcct ctgccacccc tgagctgtcc 180
ccctcttctg gtccccggaa gaccacccgg ccattcaagg tgatcatcaa gccccctgtg 240
ccccctgccc ccatcatgct gcccctgatc aagcaggagg acatcaagcc tgagcctgac 300
ttcaccatcc agtaccggaa caagatcatt gacacagctg gctgcattgt gatctctgac 360
tctgaggagg agcagggcga ggaggtggag acccggggcg ccacagcctc ctccccatcc 420
acaggctctg gcaccccccg ggtgacctcc cccacccatc ccctgtccca gatgaaccat 480
ccccccctgc ctgaccccct gggccggcct gatgaggact cctcctcctc ctcctcctcc 540
tcctgctcct ctgcctctga ctctgagtct gagtctgagg agatgaagtg ctcctctggc 600
ggcggcgcct ctgtgacctc ctcccatcat ggccggggcg gctttggcgg cgctgcctcc 660
tcctccctgc tgtcctgtgg ccatcagtcc tctggcggcg cctccacagg cccccggtct 720
tctggttcca agcggatctc tgagctggac aatgagaagg tgcggaacat catgaaggac 780
aagaacaccc cattctgcac ccccaatgtg cagacccggc ggggccgggt gaagattgat 840
gaggtctccc ggatgttccg gaacaccaac cggtccctgg agtacaagaa cctgccattc 900
accatcccat ccatgcatca ggtgctggat gaggccatca aggcctgcaa gaccatgcag 960
gtgaacaaca agggcatcca gatcatctac acccggaacc atgaggtgaa gtctgaggtg 1020
gatgctgtgc ggtgccggct gggcaccatg tgcaacctgg ccctgtccac cccattcctg 1080
atggagcaca ccatgcctgt gacccatccc cctgaggtgg cccagcggac agctgatgcc 1140
tgcaatgagg gcgtgaaggc tgcctggtcc ctgaaggagc tgcacaccca tcagctgtgc 1200
ccccggtcct ctgactaccg gaacatgatc atccatgctg ccacccctgt ggacctgctg 1260
ggcgccctga acctgtgcct gcccctgatg cagaagttcc ccaagcaggt gatggtgcgg 1320
atcttctcca ccaaccaggg cggcttcatg ctgcccatct atgagacagc tgccaaggcc 1380
tatgctgtgg gccagtttga gcagcccaca gagacccccc ctgaggacct ggacaccctg 1440
tccctggcca ttgaggctgc catccaggac ctgcggaaca agtcccaggg tggatccggt 1500
ggagagtctc gtggtcgtcg gtgccctgag atgatctctg tgctgggacc catctctggc 1560
catgtgctga aggctgtctt ctctcgggga gacacccctg tgctgcctca tgagacccgg 1620
ctgcttcaga caggcatcca tgtgcgggtc tcccagccat ccctgatcct ggtctcccag 1680
tacacccctg actctacccc atgccatcgg ggtgacaacc agcttcaggt gcagcacacc 1740
tacttcacag gctctgaggt ggagaatgtc tctgtgaatg ttcacaaccc tacaggccgg 1800
tccatctgcc catcccagga gcccatgtcc atctatgtct atgccctgcc tctgaagatg 1860
ctgaacatcc catccatcaa tgtgcatcac tacccatctg ctgctgagcg gaagcatcgg 1920
catctgcctg tggctgatgc tgtgatccat gcctctggca agcagatgtg gcaggctcgg 1980
ctgacagtct ctggcctggc ctggactcgg cagcagaacc agtggaagga gcctgatgtc 2040
tactacacct ctgcctttgt cttccccacc aaggatgtgg ctctgcggca tgtggtctgt 2100
gctcatgagc tggtctgctc tatggagaac actcgggcca ccaagatgca ggtgattggt 2160
gaccagtatg tgaaggtcta cctggagtcc ttctgtgagg atgtgccatc tggcaagctg 2220
ttcatgcatg tgaccctggg ctctgatgtg gaggaggacc tgaccatgac tcggaaccct 2280
cagccattca tgcggcctca tgagcggaat ggcttcacag tgctgtgccc taagaacatg 2340
atcatcaagc ctggcaagat cagccacatc atgctggatg tggccttcac ctcccatgag 2400
cactttggcc tgctgtgccc caagtccatc cctggcctgt ccatctctgg caacctgctg 2460
atgaatggcc agcagatatt cctggaggtg caggccatcc gggagacagt ggagctgcgg 2520
cagtatgacc ctgtggctgc tctgttcttc tttgacattg acctgctact gcagcggggc 2580
cctcagtact ctgagcatcc caccttcacc tcccagtacc gtatccaggg caagctggag 2640
taccggcaca cctgggaccg gcatgatgag ggtgctgccc agggtgatga tgatgtctgg 2700
acctctggct ctgactctga tgaggagctg gtgaccacag agggtggcac ccctggtgtg 2760
acaggtggag gtgctatggc tggtgcctcc acctctgctg gtcggggtcg gaagtctgcc 2820
tcctctgcca cagcttgcac ctctggtgtg atgactcgtg gtcggctgaa ggctgagtcc 2880
acagtggctc ctgaggagga cacagatgag gactctgaca atgagatcca caaccctgct 2940
gtcttcacct ggcctccatg gcaggctggc atcctggctc ggaacctggt gcctatggtg 3000
gccacagtgc agggtcagaa cctgaagtac caggagttct tctgggatgc caatgacatc 3060
taccggatct ttgctgagct ggagggtgtc tggcagcctg ctgccggtgg tagtggagga 3120
cctgagaagg atgtgctggc tgagctggtg aagcagatca aggtgcgggt ggacatggtg 3180
cggcatcgga tcaaggagca catgctgaag aagtacaccc agacagagga gaagttcaca 3240
ggcgccttca acatgatggg tggctgcctg cagaatgccc tggacatcct ggacaaggtg 3300
catgagccat ttgaggagat gaagtgcatt ggcctgacca tgcagtccat gtatgagaac 3360
tacattgtgc ctgaggacaa gcgggagatg tggatggcct gcatcaagga gctgcatgat 3420
gtctccaagg gcgctgccaa caagctgggc ggtgccctgc aggccaaggc ccgggccaag 3480
aaggatgagc tgcggcggaa gatgatgtac atgtgctacc ggaacattga gttcttcacc 3540
aagaactctg ccttccccaa gaccaccaat ggctgctccc aggccatggc tgccctgcag 3600
aacctgcccc agtgctcccc tgatgagatc atggcctatg cccagaagat attcaagatc 3660
ctggatgagg agcgggacaa ggtgctgacc cacattgacc acatcttcat ggacatcctg 3720
accacctgtg tggagaccat gtgcaatgag tacaaggtga cctctgatgc ctgcatgatg 3780
accatgtatg gcggcatctc cctgctgtct gagttctgcc gggtgctgtg ctgctatgtg 3840
ctggaggaga cctctgtgat gctggccaag cggcccctga tcaccaagcc tgaggtgatc 3900
tctgtgatgg gtggcggtat tgaggagatc agcatgaagg tctttgccca gtacatcctg 3960
ggcgctgacc ctctgcgggt ctgctcccca tctgtggatg acctgcgggc cattgctgag 4020
gagtctgatg aggaggaggc cattgtggcc tacaccctgg ccacagctgg cgtctcctcc 4080
tctgactccc tggtctcccc ccctgagtcc cctgtgcctg ccaccatccc cctgtcctct 4140
gtgattgtgg ctgagaactc tgaccaggag gagtctgagc agtctgatga ggaggaggag 4200
gagggtgccc aggaggagcg ggaggacaca gtctctgtga agtctgagcc tgtctctgag 4260
attgaggagg tggcccctga ggaggaggag gatggcgctg aggagcccac agcctctggc 4320
ggcaagtcca cccatcccat ggtgacccgg tccaaggctg accagtaa              4368

<210> 26
<211> 1455
<212> PRT
<213> Artificial Sequence

<220> 
<223> mIE2-linker-mIE1-linker-mpp65 fusion protein (21P)

<400> 26
Met Gly Asp Ile Leu Ala Gln Ala Val Asn His Ala Gly Ile Asp Ser
 1               5                  10                  15      
Ser Ser Thr Gly Pro Thr Leu Thr Thr His Ser Cys Ser Val Ser Ser
            20                  25                  30          
Ala Pro Leu Asn Lys Pro Thr Pro Thr Ser Val Ala Val Thr Asn Thr
        35                  40                  45              
Pro Leu Pro Gly Ala Ser Ala Thr Pro Glu Leu Ser Pro Ser Ser Gly
    50                  55                  60                  
Pro Arg Lys Thr Thr Arg Pro Phe Lys Val Ile Ile Lys Pro Pro Val
65                  70                  75                  80  
Pro Pro Ala Pro Ile Met Leu Pro Leu Ile Lys Gln Glu Asp Ile Lys
                85                  90                  95      
Pro Glu Pro Asp Phe Thr Ile Gln Tyr Arg Asn Lys Ile Ile Asp Thr
            100                 105                 110         
Ala Gly Cys Ile Val Ile Ser Asp Ser Glu Glu Glu Gln Gly Glu Glu
        115                 120                 125             
Val Glu Thr Arg Gly Ala Thr Ala Ser Ser Pro Ser Thr Gly Ser Gly
    130                 135                 140                 
Thr Pro Arg Val Thr Ser Pro Thr His Pro Leu Ser Gln Met Asn His
145                 150                 155                 160 
Pro Pro Leu Pro Asp Pro Leu Gly Arg Pro Asp Glu Asp Ser Ser Ser
                165                 170                 175     
Ser Ser Ser Ser Ser Cys Ser Ser Ala Ser Asp Ser Glu Ser Glu Ser
            180                 185                 190         
Glu Glu Met Lys Cys Ser Ser Gly Gly Gly Ala Ser Val Thr Ser Ser
        195                 200                 205             
His His Gly Arg Gly Gly Phe Gly Gly Ala Ala Ser Ser Ser Leu Leu
    210                 215                 220                 
Ser Cys Gly His Gln Ser Ser Gly Gly Ala Ser Thr Gly Pro Arg Ser
225                 230                 235                 240 
Ser Gly Ser Lys Arg Ile Ser Glu Leu Asp Asn Glu Lys Val Arg Asn
                245                 250                 255     
Ile Met Lys Asp Lys Asn Thr Pro Phe Cys Thr Pro Asn Val Gln Thr
            260                 265                 270         
Arg Arg Gly Arg Val Lys Ile Asp Glu Val Ser Arg Met Phe Arg Asn
        275                 280                 285             
Thr Asn Arg Ser Leu Glu Tyr Lys Asn Leu Pro Phe Thr Ile Pro Ser
    290                 295                 300                 
Met His Gln Val Leu Asp Glu Ala Ile Lys Ala Cys Lys Thr Met Gln
305                 310                 315                 320 
Val Asn Asn Lys Gly Ile Gln Ile Ile Tyr Thr Arg Asn His Glu Val
                325                 330                 335     
Lys Ser Glu Val Asp Ala Val Arg Cys Arg Leu Gly Thr Met Cys Asn
            340                 345                 350         
Leu Ala Leu Ser Thr Pro Phe Leu Met Glu His Thr Met Pro Val Thr
        355                 360                 365             
His Pro Pro Glu Val Ala Gln Arg Thr Ala Asp Ala Cys Asn Glu Gly
    370                 375                 380                 
Val Lys Ala Ala Trp Ser Leu Lys Glu Leu His Thr His Gln Leu Cys
385                 390                 395                 400 
Pro Arg Ser Ser Asp Tyr Arg Asn Met Ile Ile His Ala Ala Thr Pro
                405                 410                 415     
Val Asp Leu Leu Gly Ala Leu Asn Leu Cys Leu Pro Leu Met Gln Lys
            420                 425                 430         
Phe Pro Lys Gln Val Met Val Arg Ile Phe Ser Thr Asn Gln Gly Gly
        435                 440                 445             
Phe Met Leu Pro Ile Tyr Glu Thr Ala Ala Lys Ala Tyr Ala Val Gly
    450                 455                 460                 
Gln Phe Glu Gln Pro Thr Glu Thr Pro Pro Glu Asp Leu Asp Thr Leu
465                 470                 475                 480 
Ser Leu Ala Ile Glu Ala Ala Ile Gln Asp Leu Arg Asn Lys Ser Gln
                485                 490                 495     
Gly Gly Ser Gly Gly Pro Glu Lys Asp Val Leu Ala Glu Leu Val Lys
            500                 505                 510         
Gln Ile Lys Val Arg Val Asp Met Val Arg His Arg Ile Lys Glu His
        515                 520                 525             
Met Leu Lys Lys Tyr Thr Gln Thr Glu Glu Lys Phe Thr Gly Ala Phe
    530                 535                 540                 
Asn Met Met Gly Gly Cys Leu Gln Asn Ala Leu Asp Ile Leu Asp Lys
545                 550                 555                 560 
Val His Glu Pro Phe Glu Glu Met Lys Cys Ile Gly Leu Thr Met Gln
                565                 570                 575     
Ser Met Tyr Glu Asn Tyr Ile Val Pro Glu Asp Lys Arg Glu Met Trp
            580                 585                 590         
Met Ala Cys Ile Lys Glu Leu His Asp Val Ser Lys Gly Ala Ala Asn
        595                 600                 605             
Lys Leu Gly Gly Ala Leu Gln Ala Lys Ala Arg Ala Lys Lys Asp Glu
    610                 615                 620                 
Leu Arg Arg Lys Met Met Tyr Met Cys Tyr Arg Asn Ile Glu Phe Phe
625                 630                 635                 640 
Thr Lys Asn Ser Ala Phe Pro Lys Thr Thr Asn Gly Cys Ser Gln Ala
                645                 650                 655     
Met Ala Ala Leu Gln Asn Leu Pro Gln Cys Ser Pro Asp Glu Ile Met
            660                 665                 670         
Ala Tyr Ala Gln Lys Ile Phe Lys Ile Leu Asp Glu Glu Arg Asp Lys
        675                 680                 685             
Val Leu Thr His Ile Asp His Ile Phe Met Asp Ile Leu Thr Thr Cys
    690                 695                 700                 
Val Glu Thr Met Cys Asn Glu Tyr Lys Val Thr Ser Asp Ala Cys Met
705                 710                 715                 720 
Met Thr Met Tyr Gly Gly Ile Ser Leu Leu Ser Glu Phe Cys Arg Val
                725                 730                 735     
Leu Cys Cys Tyr Val Leu Glu Glu Thr Ser Val Met Leu Ala Lys Arg
            740                 745                 750         
Pro Leu Ile Thr Lys Pro Glu Val Ile Ser Val Met Gly Gly Gly Ile
        755                 760                 765             
Glu Glu Ile Ser Met Lys Val Phe Ala Gln Tyr Ile Leu Gly Ala Asp
    770                 775                 780                 
Pro Leu Arg Val Cys Ser Pro Ser Val Asp Asp Leu Arg Ala Ile Ala
785                 790                 795                 800 
Glu Glu Ser Asp Glu Glu Glu Ala Ile Val Ala Tyr Thr Leu Ala Thr
                805                 810                 815     
Ala Gly Val Ser Ser Ser Asp Ser Leu Val Ser Pro Pro Glu Ser Pro
            820                 825                 830         
Val Pro Ala Thr Ile Pro Leu Ser Ser Val Ile Val Ala Glu Asn Ser
        835                 840                 845             
Asp Gln Glu Glu Ser Glu Gln Ser Asp Glu Glu Glu Glu Glu Gly Ala
    850                 855                 860                 
Gln Glu Glu Arg Glu Asp Thr Val Ser Val Lys Ser Glu Pro Val Ser
865                 870                 875                 880 
Glu Ile Glu Glu Val Ala Pro Glu Glu Glu Glu Asp Gly Ala Glu Glu
                885                 890                 895     
Pro Thr Ala Ser Gly Gly Lys Ser Thr His Pro Met Val Thr Arg Ser
            900                 905                 910         
Lys Ala Asp Gln Gly Gly Ser Gly Gly Glu Ser Arg Gly Arg Arg Cys
        915                 920                 925             
Pro Glu Met Ile Ser Val Leu Gly Pro Ile Ser Gly His Val Leu Lys
    930                 935                 940                 
Ala Val Phe Ser Arg Gly Asp Thr Pro Val Leu Pro His Glu Thr Arg
945                 950                 955                 960 
Leu Leu Gln Thr Gly Ile His Val Arg Val Ser Gln Pro Ser Leu Ile
                965                 970                 975     
Leu Val Ser Gln Tyr Thr Pro Asp Ser Thr Pro Cys His Arg Gly Asp
            980                 985                 990         
Asn Gln Leu Gln Val Gln His Thr Tyr Phe Thr Gly Ser Glu Val Glu
        995                 1000                1005            
Asn Val Ser Val Asn Val His Asn Pro Thr Gly Arg Ser Ile Cys Pro
    1010                1015                1020                
Ser Gln Glu Pro Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met
1025                1030                1035               1040 
Leu Asn Ile Pro Ser Ile Asn Val His His Tyr Pro Ser Ala Ala Glu
                1045                1050                1055    
Arg Lys His Arg His Leu Pro Val Ala Asp Ala Val Ile His Ala Ser
            1060                1065                1070        
Gly Lys Gln Met Trp Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp
        1075                1080                1085            
Thr Arg Gln Gln Asn Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser
    1090                1095                1100                
Ala Phe Val Phe Pro Thr Lys Asp Val Ala Leu Arg His Val Val Cys
1105                1110                1115               1120 
Ala His Glu Leu Val Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met
                1125                1130                1135    
Gln Val Ile Gly Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys
            1140                1145                1150        
Glu Asp Val Pro Ser Gly Lys Leu Phe Met His Val Thr Leu Gly Ser
        1155                1160                1165            
Asp Val Glu Glu Asp Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met
    1170                1175                1180                
Arg Pro His Glu Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met
1185                1190                1195               1200 
Ile Ile Lys Pro Gly Lys Ile Ser His Ile Met Leu Asp Val Ala Phe
                1205                1210                1215    
Thr Ser His Glu His Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly
            1220                1225                1230        
Leu Ser Ile Ser Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu
        1235                1240                1245            
Glu Val Gln Ala Ile Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro
    1250                1255                1260                
Val Ala Ala Leu Phe Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly
1265                1270                1275               1280 
Pro Gln Tyr Ser Glu His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln
                1285                1290                1295    
Gly Lys Leu Glu Tyr Arg His Thr Trp Asp Arg His Asp Glu Gly Ala
            1300                1305                1310        
Ala Gln Gly Asp Asp Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu
        1315                1320                1325            
Glu Leu Val Thr Thr Glu Gly Gly Thr Pro Gly Val Thr Gly Gly Gly
    1330                1335                1340                
Ala Met Ala Gly Ala Ser Thr Ser Ala Gly Arg Gly Arg Lys Ser Ala
1345                1350                1355               1360 
Ser Ser Ala Thr Ala Cys Thr Ser Gly Val Met Thr Arg Gly Arg Leu
                1365                1370                1375    
Lys Ala Glu Ser Thr Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser
            1380                1385                1390        
Asp Asn Glu Ile His Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln
        1395                1400                1405            
Ala Gly Ile Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln
    1410                1415                1420                
Gly Gln Asn Leu Lys Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile
1425                1430                1435               1440 
Tyr Arg Ile Phe Ala Glu Leu Glu Gly Val Trp Gln Pro Ala Ala
                1445                1450                1455


<210> 27
<211> 4368
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence encoding 21P

<400> 27
atgggcgaca tcctggccca ggctgtgaac catgctggca ttgactcctc ctccacaggc 60
cccaccctga ccacccactc ctgctctgtc tcctctgccc ccctgaacaa gcccaccccc 120
acctctgtgg ctgtgaccaa cacccccctg cctggcgcct ctgccacccc tgagctgtcc 180
ccctcttctg gtccccggaa gaccacccgg ccattcaagg tgatcatcaa gccccctgtg 240
ccccctgccc ccatcatgct gcccctgatc aagcaggagg acatcaagcc tgagcctgac 300
ttcaccatcc agtaccggaa caagatcatt gacacagctg gctgcattgt gatctctgac 360
tctgaggagg agcagggcga ggaggtggag acccggggcg ccacagcctc ctccccatcc 420
acaggctctg gcaccccccg ggtgacctcc cccacccatc ccctgtccca gatgaaccat 480
ccccccctgc ctgaccccct gggccggcct gatgaggact cctcctcctc ctcctcctcc 540
tcctgctcct ctgcctctga ctctgagtct gagtctgagg agatgaagtg ctcctctggc 600
ggcggcgcct ctgtgacctc ctcccatcat ggccggggcg gctttggcgg cgctgcctcc 660
tcctccctgc tgtcctgtgg ccatcagtcc tctggcggcg cctccacagg cccccggtct 720
tctggttcca agcggatctc tgagctggac aatgagaagg tgcggaacat catgaaggac 780
aagaacaccc cattctgcac ccccaatgtg cagacccggc ggggccgggt gaagattgat 840
gaggtctccc ggatgttccg gaacaccaac cggtccctgg agtacaagaa cctgccattc 900
accatcccat ccatgcatca ggtgctggat gaggccatca aggcctgcaa gaccatgcag 960
gtgaacaaca agggcatcca gatcatctac acccggaacc atgaggtgaa gtctgaggtg 1020
gatgctgtgc ggtgccggct gggcaccatg tgcaacctgg ccctgtccac cccattcctg 1080
atggagcaca ccatgcctgt gacccatccc cctgaggtgg cccagcggac agctgatgcc 1140
tgcaatgagg gcgtgaaggc tgcctggtcc ctgaaggagc tgcacaccca tcagctgtgc 1200
ccccggtcct ctgactaccg gaacatgatc atccatgctg ccacccctgt ggacctgctg 1260
ggcgccctga acctgtgcct gcccctgatg cagaagttcc ccaagcaggt gatggtgcgg 1320
atcttctcca ccaaccaggg cggcttcatg ctgcccatct atgagacagc tgccaaggcc 1380
tatgctgtgg gccagtttga gcagcccaca gagacccccc ctgaggacct ggacaccctg 1440
tccctggcca ttgaggctgc catccaggac ctgcggaaca agtcccaggg tggatccggt 1500
ggacctgaga aggatgtgct ggctgagctg gtgaagcaga tcaaggtgcg ggtggacatg 1560
gtgcggcatc ggatcaagga gcacatgctg aagaagtaca cccagacaga ggagaagttc 1620
acaggcgcct tcaacatgat gggtggctgc ctgcagaatg ccctggacat cctggacaag 1680
gtgcatgagc catttgagga gatgaagtgc attggcctga ccatgcagtc catgtatgag 1740
aactacattg tgcctgagga caagcgggag atgtggatgg cctgcatcaa ggagctgcat 1800
gatgtctcca agggcgctgc caacaagctg ggcggtgccc tgcaggccaa ggcccgggcc 1860
aagaaggatg agctgcggcg gaagatgatg tacatgtgct accggaacat tgagttcttc 1920
accaagaact ctgccttccc caagaccacc aatggctgct cccaggccat ggctgccctg 1980
cagaacctgc cccagtgctc ccctgatgag atcatggcct atgcccagaa gatattcaag 2040
atcctggatg aggagcggga caaggtgctg acccacattg accacatctt catggacatc 2100
ctgaccacct gtgtggagac catgtgcaat gagtacaagg tgacctctga tgcctgcatg 2160
atgaccatgt atggcggcat ctccctgctg tctgagttct gccgggtgct gtgctgctat 2220
gtgctggagg agacctctgt gatgctggcc aagcggcccc tgatcaccaa gcctgaggtg 2280
atctctgtga tgggtggcgg tattgaggag atcagcatga aggtctttgc ccagtacatc 2340
ctgggcgctg accctctgcg ggtctgctcc ccatctgtgg atgacctgcg ggccattgct 2400
gaggagtctg atgaggagga ggccattgtg gcctacaccc tggccacagc tggcgtctcc 2460
tcctctgact ccctggtctc cccccctgag tcccctgtgc ctgccaccat ccccctgtcc 2520
tctgtgattg tggctgagaa ctctgaccag gaggagtctg agcagtctga tgaggaggag 2580
gaggagggtg cccaggagga gcgggaggac acagtctctg tgaagtctga gcctgtctct 2640
gagattgagg aggtggcccc tgaggaggag gaggatggcg ctgaggagcc cacagcctct 2700
ggcggcaagt ccacccatcc catggtgacc cggtccaagg ctgaccaggg tggtagtgga 2760
ggagagtctc gtggtcgtcg gtgccctgag atgatctctg tgctgggacc catctctggc 2820
catgtgctga aggctgtctt ctctcgggga gacacccctg tgctgcctca tgagacccgg 2880
ctgcttcaga caggcatcca tgtgcgggtc tcccagccat ccctgatcct ggtctcccag 2940
tacacccctg actctacccc atgccatcgg ggtgacaacc agcttcaggt gcagcacacc 3000
tacttcacag gctctgaggt ggagaatgtc tctgtgaatg ttcacaaccc tacaggccgg 3060
tccatctgcc catcccagga gcccatgtcc atctatgtct atgccctgcc tctgaagatg 3120
ctgaacatcc catccatcaa tgtgcatcac tacccatctg ctgctgagcg gaagcatcgg 3180
catctgcctg tggctgatgc tgtgatccat gcctctggca agcagatgtg gcaggctcgg 3240
ctgacagtct ctggcctggc ctggactcgg cagcagaacc agtggaagga gcctgatgtc 3300
tactacacct ctgcctttgt cttccccacc aaggatgtgg ctctgcggca tgtggtctgt 3360
gctcatgagc tggtctgctc tatggagaac actcgggcca ccaagatgca ggtgattggt 3420
gaccagtatg tgaaggtcta cctggagtcc ttctgtgagg atgtgccatc tggcaagctg 3480
ttcatgcatg tgaccctggg ctctgatgtg gaggaggacc tgaccatgac tcggaaccct 3540
cagccattca tgcggcctca tgagcggaat ggcttcacag tgctgtgccc taagaacatg 3600
atcatcaagc ctggcaagat cagccacatc atgctggatg tggccttcac ctcccatgag 3660
cactttggcc tgctgtgccc caagtccatc cctggcctgt ccatctctgg caacctgctg 3720
atgaatggcc agcagatatt cctggaggtg caggccatcc gggagacagt ggagctgcgg 3780
cagtatgacc ctgtggctgc tctgttcttc tttgacattg acctgctact gcagcggggc 3840
cctcagtact ctgagcatcc caccttcacc tcccagtacc gtatccaggg caagctggag 3900
taccggcaca cctgggaccg gcatgatgag ggtgctgccc agggtgatga tgatgtctgg 3960
acctctggct ctgactctga tgaggagctg gtgaccacag agggtggcac ccctggtgtg 4020
acaggtggag gtgctatggc tggtgcctcc acctctgctg gtcggggtcg gaagtctgcc 4080
tcctctgcca cagcttgcac ctctggtgtg atgactcgtg gtcggctgaa ggctgagtcc 4140
acagtggctc ctgaggagga cacagatgag gactctgaca atgagatcca caaccctgct 4200
gtcttcacct ggcctccatg tcaggctggc atcctggctc ggaacctggt gcctatggtg 4260
gccacagtgc agggtcagaa cctgaagtac caggagttct tctgggatgc caatgacatc 4320
taccggatct ttgctgagct ggagggtgtc tgtcagcctg ctgcctaa              4368

<210> 28
<211> 5761
<212> DNA
<213> Artificial Sequence

<220> 
<223> plasmid V1Jns

<400> 28
agatctgccg ccaccatgcg gatctttgct gtgttcatct tcatgaccta ctggcacctg 60
ctgaatgcct tcactgtgac tgtgcccaag gacctgtatg tggtggagta tggctccaac 120
atgaccattg agtgcaagtt ccctgtggag aagcagctgg acctggctgc cctgattgtg 180
tactgggaga tggaggacaa gaacatcatc cagtttgtgc atggcgagga ggacctgaag 240
gtgcagcact cctcctaccg gcagcgggcc cggctgctga aggaccagct gagcctgggc 300
aatgccgccc tgcagatcac tgatgtgaag ctgcaggatg ctggcgtgta ccggtgcatg 360
atctcctatg gcggcgctga ctacaagcgg atcactgtga aggtgaatgc cccctacaac 420
aagatcaacc agcgtatcct ggtggtggac cccgtgacct ctgagcatga gctgacctgc 480
caggctgagg gctaccccaa ggctgaggtg atctggacct cctctgacca ccaggtgctg 540
agtggcaaga ccaccaccac caactccaag cgggaggaga agctgttcaa tgtgacctcc 600
accctgcgga tcaacaccac caccaatgag atcttctact gcaccttccg gcggctggac 660
cctgaggaga accacactgc tgagctggtg atccctgagc tgcccctggc ccaccctccc 720
aatgagcgga cccacctggt gatcctgggc gccatcctgc tgtgcctggg cgtggccctg 780
accttcatct tccggctgcg gaagggccgg atgatggatg tgaagaagtg tggcatccag 840
gacaccaact ccaagaagca gtctgacacc cacctggagg agacctaaac ataatgatct 900
gctgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc 960
ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt 1020
ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat 1080
tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggccgc tgcggccagg 1140
tgctgaagaa ttgacccggt tcctcctggg ccagaaagaa gcaggcacat ccccttctct 1200
gtgacacacc ctgtccacgc ccctggttct tagttccagc cccactcata ggacactcat 1260
agctcaggag ggctccgcct tcaatcccac ccgctaaagt acttggagcg gtctctccct 1320
ccctcatcag cccaccaaac caaacctagc ctccaagagt gggaagaaat taaagcaaga 1380
taggctatta agtgcagagg gagagaaaat gcctccaaca tgtgaggaag taatgagaga 1440
aatcatagaa tttcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg 1500
cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat 1560
aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc 1620
gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc 1680
tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga 1740
agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt 1800
ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg 1860
taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc 1920
gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg 1980
gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc 2040
ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg 2100
ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc 2160
gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct 2220
caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt 2280
taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa 2340
aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa 2400
tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc 2460
tgactcgggg ggggggggcg ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac 2520
caggcctgaa tcgccccatc atccagccag aaagtgaggg agccacggtt gatgagagct 2580
ttgttgtagg tggaccagtt ggtgattttg aacttttgct ttgccacgga acggtctgcg 2640
ttgtcgggaa gatgcgtgat ctgatccttc aactcagcaa aagttcgatt tattcaacaa 2700
agccgccgtc ccgtcaagtc agcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt 2760
ctgattagaa aaactcatcg agcatcaaat gaaactgcaa tttattcata tcaggattat 2820
caataccata tttttgaaaa agccgtttct gtaatgaagg agaaaactca ccgaggcagt 2880
tccataggat ggcaagatcc tggtatcggt ctgcgattcc gactcgtcca acatcaatac 2940
aacctattaa tttcccctcg tcaaaaataa ggttatcaag tgagaaatca ccatgagtga 3000
cgactgaatc cggtgagaat ggcaaaagct tatgcatttc tttccagact tgttcaacag 3060
gccagccatt acgctcgtca tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg 3120
attgcgcctg agcgagacga aatacgcgat cgctgttaaa aggacaatta caaacaggaa 3180
tcgaatgcaa ccggcgcagg aacactgcca gcgcatcaac aatattttca cctgaatcag 3240
gatattcttc taatacctgg aatgctgttt tcccggggat cgcagtggtg agtaaccatg 3300
catcatcagg agtacggata aaatgcttga tggtcggaag aggcataaat tccgtcagcc 3360
agtttagtct gaccatctca tctgtaacat cattggcaac gctacctttg ccatgtttca 3420
gaaacaactc tggcgcatcg ggcttcccat acaatcgata gattgtcgca cctgattgcc 3480
cgacattatc gcgagcccat ttatacccat ataaatcagc atccatgttg gaatttaatc 3540
gcggcctcga gcaagacgtt tcccgttgaa tatggctcat aacacccctt gtattactgt 3600
ttatgtaagc agacagtttt attgttcatg atgatatatt tttatcttgt gcaatgtaac 3660
atcagagatt ttgagacaca acgtggcttt cccccccccc ccattattga agcatttatc 3720
agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag 3780
gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca 3840
tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtctcgcg cgtttcggtg 3900
atgacggtga aaacctctga cacatgcagc tcccggagac ggtcacagct tgtctgtaag 3960
cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg 4020
gctggcttaa ctatgcggca tcagagcaga ttgtactgag agtgcaccat atgcggtgtg 4080
aaataccgca cagatgcgta aggagaaaat accgcatcag attggctatt ggccattgca 4140
tacgttgtat ccatatcata atatgtacat ttatattggc tcatgtccaa cattaccgcc 4200
atgttgacat tgattattga ctagttatta atagtaatca attacggggt cattagttca 4260
tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc 4320
gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat 4380
agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt 4440
acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc 4500
cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta 4560
cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg 4620
atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt 4680
gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac 4740
gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa 4800
ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga 4860
ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc gtgccaagag 4920
tgacgtaagt accgcctata gactctatag gcacacccct ttggctctta tgcatgctat 4980
actgtttttg gcttggggcc tatacacccc cgcttcctta tgctataggt gatggtatag 5040
cttagcctat aggtgtgggt tattgaccat tattgaccac tcccctattg gtgacgatac 5100
tttccattac taatccataa catggctctt tgccacaact atctctattg gctatatgcc 5160
aatactctgt ccttcagaga ctgacacgga ctctgtattt ttacaggatg gggtcccatt 5220
tattatttac aaattcacat atacaacaac gccgtccccc gtgcccgcag tttttattaa 5280
acatagcgtg ggatctccac gcgaatctcg ggtacgtgtt ccggacatgg gctcttctcc 5340
ggtagcggcg gagcttccac atccgagccc tggtcccatg cctccagcgg ctcatggtcg 5400
ctcggcagct ccttgctcct aacagtggag gccagactta ggcacagcac aatgcccacc 5460
accaccagtg tgccgcacaa ggccgtggcg gtagggtatg tgtctgaaaa tgagcgtgga 5520
gattgggctc gcacggctga cgcagatgga agacttaagg cagcggcaga agaagatgca 5580
ggcagctgag ttgttgtatt ctgataagag tcagaggtaa ctcccgttgc ggtgctgtta 5640
acggtggagg gcagtgtagt ctgagcagta ctcgttgctg ccgcgcgcgc caccagacat 5700
aatagctgac agactaacag actgttcctt tccatgggtc ttttctgcag tcaccgtcct 5760
t                                                                 5761



<210> 29
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker

<400> 29
Gly Gly Ser Gly Gly
 1               5  


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 30
Val Leu Gly Pro Ile Ser Gly His Val
 1               5                  


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 31
Ile Pro Ser Ile Asn Val His His Tyr
 1               5                  


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 32
Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu
 1               5                  10      


<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 33
Ile Leu Ala Arg Asn Leu Val Pro Met
 1               5                  


<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 34
Asn Leu Val Pro Met Val Ala Thr Val
 1               5                  


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 35
Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr
 1               5                  10  


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 36
Leu Leu Gln Thr Gly Ile His Val Arg Val Ser Gln Pro Ser Leu
 1               5                  10                  15  


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 37
Ala Cys Thr Ser Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu
 1               5                  10                  15  


<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 38
Val Leu Ala Glu Leu Val Lys Gln Ile
 1               5                  


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 39
Gln Ile Lys Val Arg Val Asp Met Val
 1               5                  


<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 40
Asp Glu Leu Arg Arg Lys Met Met Tyr Met
 1               5                  10  


<210> 41
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 41
Cys Val Glu Thr Met Cys Asn Glu Tyr
 1               5                  


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 42
Val Leu Glu Glu Thr Ser Val Met Leu
 1               5                  


<210> 43
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 43
Val Arg Val Asp Met Val Arg His Arg Ile Lys Glu His Met Leu Lys
 1               5                  10                  15      
Lys Tyr Thr Gln
            20  


<210> 44
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> T-cell epitope

<400> 44
Asp Lys Arg Glu Met Trp Met Ala Cys Ile Lys Glu Leu His
 1               5                  10                  

