  
                                  SEQUENCE LISTING
  
  <110> Promega Corporation
        Goueli, Said A.
        Zegzouti, Hicham
  
  <120> ADP DETECTION BASED LUMINESCENT PHOSPHOTRANSFERASE OR ATP HYDROLASE
       ASSAY
    
  
  <130> 341.069WO1
  
  <150> US 61/082,775       
  <151> 2008-07-22  
  
  <150> US 61/170,308       
  <151> 2009-04-17  
  
  <150> US 61/182,372       
  <151> 2009-05-29  
  
  <160> 15
  
  <170> FastSEQ for Windows Version 4.0
  
  <210> 1
  <211> 1706
  <212> PRT
  <213> Bordetella pertussis
  
  <400> 1
  Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu
   1               5                  10                  15      
  Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys
              20                  25                  30          
  Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr
          35                  40                  45              
  Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala
      50                  55                  60                  
  
  Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro
  65                  70                  75                  80  
  Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala
                  85                  90                  95      
  Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp
              100                 105                 110         
  Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu
          115                 120                 125             
  Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr
      130                 135                 140                 
  Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala
  145                 150                 155                 160 
  Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val
                  165                 170                 175     
  Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe
              180                 185                 190         
  Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser
          195                 200                 205             
  Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg
      210                 215                 220                 
  Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu
  225                 230                 235                 240 
  Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu
                  245                 250                 255     
  Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile
              260                 265                 270         
  Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His
          275                 280                 285             
  Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn
      290                 295                 300                 
  Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly
  305                 310                 315                 320 
  Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln
                  325                 330                 335     
  Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val
              340                 345                 350         
  Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val
          355                 360                 365             
  
  Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro
      370                 375                 380                 
  Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln
  385                 390                 395                 400 
  Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser
                  405                 410                 415     
  Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu
              420                 425                 430         
  Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu
          435                 440                 445             
  Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln
      450                 455                 460                 
  Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala
  465                 470                 475                 480 
  Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu
                  485                 490                 495     
  Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser
              500                 505                 510         
  Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp
          515                 520                 525             
  Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly
      530                 535                 540                 
  Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro
  545                 550                 555                 560 
  Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr
                  565                 570                 575     
  Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala
              580                 585                 590         
  Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly
          595                 600                 605             
  Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr
      610                 615                 620                 
  Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala
  625                 630                 635                 640 
  Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln
                  645                 650                 655     
  Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser
              660                 665                 670         
  
  Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala
          675                 680                 685             
  Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly
      690                 695                 700                 
  Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys
  705                 710                 715                 720 
  Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln
                  725                 730                 735     
  Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn
              740                 745                 750         
  Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn
          755                 760                 765             
  Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala
      770                 775                 780                 
  Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val
  785                 790                 795                 800 
  Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln
                  805                 810                 815     
  Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg
              820                 825                 830         
  Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro
          835                 840                 845             
  Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr
      850                 855                 860                 
  Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp
  865                 870                 875                 880 
  Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu
                  885                 890                 895     
  Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val Ile
              900                 905                 910         
  Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His
          915                 920                 925             
  Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly
      930                 935                 940                 
  Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val
  945                 950                 955                 960 
  Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr
                  965                 970                 975     
  
  Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His
              980                 985                 990         
  Val Glu Leu Ala Arg Val Gly Gln Val Val Glu Val Asp Thr Leu Glu
          995                 1000                1005            
  His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser Ile Thr Gly
      1010                1015                1020                
  Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser Gly Asp Asp Arg Leu
  1025                1030                1035                1040
  Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu Gly Gln Asn
                  1045                1050                1055    
  Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe Leu Gln Asp Leu Gly
              1060                1065                1070        
  Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp Thr Val Lys
          1075                1080                1085            
  Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu Glu Arg Met Gly Asp
      1090                1095                1100                
  Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr Val Glu Lys Trp Pro
  1105                1110                1115                1120
  Ala Leu Asn Leu Phe Ser Val Asp His Val Lys Asn Ile Glu Asn Leu
                  1125                1130                1135    
  His Gly Ser Arg Leu Asn Asp Arg Ile Ala Gly Asp Asp Gln Asp Asn
              1140                1145                1150        
  Glu Leu Trp Gly His Asp Gly Asn Asp Thr Ile Arg Gly Arg Gly Gly
          1155                1160                1165            
  Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp Thr Leu Tyr Gly Glu
      1170                1175                1180                
  Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu Thr Val Ser Asp Asp
  1185                1190                1195                1200
  Ile Asp Gly Gly Ala Gly Leu Asp Thr Val Asp Tyr Ser Ala Met Ile
                  1205                1210                1215    
  His Pro Gly Arg Ile Val Ala Pro His Glu Tyr Gly Phe Gly Ile Glu
              1220                1225                1230        
  Ala Asp Leu Ser Arg Glu Trp Val Arg Lys Ala Ser Ala Leu Gly Val
          1235                1240                1245            
  Asp Tyr Tyr Asp Asn Val Arg Asn Val Glu Asn Val Ile Gly Thr Ser
      1250                1255                1260                
  Met Lys Asp Val Leu Ile Gly Asp Ala Gln Ala Asn Thr Leu Met Gly
  1265                1270                1275                1280
  
  Gln Gly Gly Asp Asp Thr Val Arg Gly Gly Asp Gly Asp Asp Leu Leu
                  1285                1290                1295    
  Phe Gly Gly Asp Gly Asn Asp Met Leu Tyr Gly Asp Ala Gly Asn Asp
              1300                1305                1310        
  Thr Leu Tyr Gly Gly Leu Gly Asp Asp Thr Leu Glu Gly Gly Ala Gly
          1315                1320                1325            
  Asn Asp Trp Phe Gly Gln Thr Gln Ala Arg Glu His Asp Val Leu Arg
      1330                1335                1340                
  Gly Gly Asp Gly Val Asp Thr Val Asp Tyr Ser Gln Thr Gly Ala His
  1345                1350                1355                1360
  Ala Gly Ile Ala Ala Gly Arg Ile Gly Leu Gly Ile Leu Ala Asp Leu
                  1365                1370                1375    
  Gly Ala Gly Arg Val Asp Lys Leu Gly Glu Ala Gly Ser Ser Ala Tyr
              1380                1385                1390        
  Asp Thr Val Ser Gly Ile Glu Asn Val Val Gly Thr Glu Leu Ala Asp
          1395                1400                1405            
  Arg Ile Thr Gly Asp Ala Gln Ala Asn Val Leu Arg Gly Ala Gly Gly
      1410                1415                1420                
  Ala Asp Val Leu Ala Gly Gly Glu Gly Asp Asp Val Leu Leu Gly Gly
  1425                1430                1435                1440
  Asp Gly Asp Asp Gln Leu Ser Gly Asp Ala Gly Arg Asp Arg Leu Tyr
                  1445                1450                1455    
  Gly Glu Ala Gly Asp Asp Trp Phe Phe Gln Asp Ala Ala Asn Ala Gly
              1460                1465                1470        
  Asn Leu Leu Asp Gly Gly Asp Gly Arg Asp Thr Val Asp Phe Ser Gly
          1475                1480                1485            
  Pro Gly Arg Gly Leu Asp Ala Gly Ala Lys Gly Val Phe Leu Ser Leu
      1490                1495                1500                
  Gly Lys Gly Phe Ala Ser Leu Met Asp Glu Pro Glu Thr Ser Asn Val
  1505                1510                1515                1520
  Leu Arg Asn Ile Glu Asn Ala Val Gly Ser Ala Arg Asp Asp Val Leu
                  1525                1530                1535    
  Ile Gly Asp Ala Gly Ala Asn Val Leu Asn Gly Leu Ala Gly Asn Asp
              1540                1545                1550        
  Val Leu Ser Gly Gly Ala Gly Asp Asp Val Leu Leu Gly Asp Glu Gly
          1555                1560                1565            
  Ser Asp Leu Leu Ser Gly Asp Ala Gly Asn Asp Asp Leu Phe Gly Gly
      1570                1575                1580                
  
  Gln Gly Asp Asp Thr Tyr Leu Phe Gly Val Gly Tyr Gly His Asp Thr
  1585                1590                1595                1600
  Ile Tyr Glu Ser Gly Gly Gly His Asp Thr Ile Arg Ile Asn Ala Gly
                  1605                1610                1615    
  Ala Asp Gln Leu Trp Phe Ala Arg Gln Gly Asn Asp Leu Glu Ile Arg
              1620                1625                1630        
  Ile Leu Gly Thr Asp Asp Ala Leu Thr Val His Asp Trp Tyr Arg Asp
          1635                1640                1645            
  Ala Asp His Arg Val Glu Ile Ile His Ala Ala Asn Gln Ala Val Asp
      1650                1655                1660                
  Gln Ala Gly Ile Glu Lys Leu Val Glu Ala Met Ala Gln Tyr Pro Asp
  1665                1670                1675                1680
  Pro Gly Ala Ala Ala Ala Ala Pro Pro Ala Ala Arg Val Pro Asp Thr
                  1685                1690                1695    
  Leu Met Gln Ser Leu Ala Val Asn Trp Arg
              1700                1705    
  
  
  <210> 2
  <211> 6382
  <212> DNA
  <213> Bordetella pertussis
  
  <400> 2
  tgcgatcatt cggcatgtac ggtccagctg cgcgcgagcg gcggccgcgt ccagcgcgcg 60
  gcctcggtac tccttgacgc gcgcggtgtc gccgccgcgc cgaacgcgca gcgaacggcc 120
  cacgctgtcg gggtgccgtt cggccagcgc gcggcgcagc gcacgattgt cgtcgcgcga 180
  gaatggcgcg atccagtcga tgatccacag tcggtcgccg cagttccagg cattcccgcc 240
  cagcgacgag ggcgccatga cataggagag ttcggtgtcg gcgtccatta gggcccagct 300
  gcagtatgca accggcacgt cattgcatcg cagcagaatg tattggccca gttgaatcgg 360
  cgcgagcgct gttgcgtgcg agcagatgca ccggccagtc gcggtgcatg ggagagttca 420
  tccacagcca ggcaatattg cccagtgccg cgaagtcgtc ggtgggattg aggagggagg 480
  gcgcttgggc ggacggaagc atgacatcgg tgcatggtgg agcggggggc atattccgtg 540
  ttgggtgcgc gcatggcaag ccgccggcgc atcatggttg cgccggaatg gcttttctta 600
  catgtttcca ggatatgtcc gtatttcggg cgatgcctcg gtcgcggcgc ctgcttttgt 660
  cgaacatgtg caatgttgtt gtcgcgatcg cgttggcgct tgctcgctta tttatctccc 720
  ttgaagcctt gttcttcttt tcattagaaa gaaatatgcg ctttgtgttt aggatgattt 780
  tcctgtccga gtagggtgga tccaaatttt ccggattggt gggaatttgt gcattttcac 840
  tgcgaatgtt ggaataattt cgcccatcgt catacgacat gctggatgtt tggttcttgc 900
  agaaggatga ggttctgagc gctacacacc ggttgcgtcg gtgcgaatcc gttcaatcga 960
  ctacttatcg acagatccac atgcagcaat cgcatcaggc tggttacgca aacgccgccg 1020
  accgggagtc tggcatcccc gcagccgtac tcgatggcat caaggccgtg gcgaaggaaa 1080
  aaaacgccac attgatgttc cgcctggtca acccccattc caccagcctg attgccgaag 1140
  gggtggccac caaaggattg ggcgtgcacg ccaagtcgtc cgattggggg ttgcaggcgg 1200
  gctacattcc cgtcaacccg aatctttcca aactgttcgg ccgtgcgccc gaggtgatcg 1260
  cgcgggccga caacgacgtc aacagcagcc tggcgcatgg ccataccgcg gtcgacctga 1320
  cgctgtcgaa agagcggctt gactatctgc ggcaagcggg cctggtcacc ggcatggccg 1380
  atggcgtggt cgcgagcaac cacgcaggct acgagcagtt cgagtttcgc gtgaaggaaa 1440
  cctcggacgg gcgctatgcc gtgcagtatc gccgcaaggg cggcgacgat ttcgaggcgg 1500
  tcaaggtgat cggcaatgcc gccggtattc cactgacggc ggatatcgac atgttcgcca 1560
  ttatgccgca tctgtccaac ttccgcgact cggcgcgcag ttcggtgacc agcggcgatt 1620
  cggtgaccga ttacctggcg cgcacgcggc gggccgccag cgaggccacg ggcggcctgg 1680
  atcgcgaacg catcgacttg ttgtggaaaa tcgctcgcgc cggcgcccgt tccgcagtgg 1740
  gcaccgaggc gcgtcgccag ttccgctacg acggcgacat gaatatcggc gtgatcaccg 1800
  atttcgagct ggaagtgcgc aatgcgctga acaggcgggc gcacgccgtc ggcgcgcagg 1860
  acgtggtcca gcatggcact gagcagaaca atcctttccc ggaggcagat gagaagattt 1920
  tcgtcgtatc ggccaccggt gaaagccaga tgctcacgcg cgggcaactg aaggaataca 1980
  ttggccagca gcgcggcgag ggctatgtct tctacgagaa ccgtgcatac ggcgtggcgg 2040
  ggaaaagcct gttcgacgat gggctgggag ccgcgcccgg cgtgccgagc ggacgttcga 2100
  agttctcgcc ggatgtactg gaaacggtgc cggcgtcacc cggattgcgg cggccgtcgc 2160
  tgggcgcagt ggaacgccag gattccggct atgacagcct tgatggggtg ggatcgcgat 2220
  cgttctcgtt gggcgaggtg tccgacatgg ccgccgtgga agcggcggaa ctggaaatga 2280
  cccggcaagt cttgcacgcc ggggcgcggc aggacgatgc cgagccgggc gtgagcggtg 2340
  cgtcggcgca ctgggggcag cgggcgctgc agggcgccca ggcggtggcg gcggcgcagc 2400
  ggctggttca tgccattgcc ctgatgacgc aattcggccg ggccggttcc accaacacgc 2460
  cgcaggaagc ggcctcgttg tcggcggccg tgttcggctt gggcgaggcc agcagcgccg 2520
  tggccgaaac cgtgagcggt tttttccgcg ggtcttcgcg ctgggccggc ggtttcggcg 2580
  tggctggcgg cgcgatggcg ctgggaggcg gcatcgccgc ggccgttggc gccgggatgt 2640
  cgttgaccga tgacgcgccg gccggacaga aggccgccgc cggcgccgag atcgcgctgc 2700
  agttgacagg tggaacggtc gagctggctt cttccatcgc gttggcgctg gccgcggcgc 2760
  gcggcgtgac cagcggcttg caggtggccg gggcgtcggc cggggcggct gccggcgcat 2820
  tggccgcggc gctcagtccc atggagatct acggcctggt gcagcaatcg cactatgcgg 2880
  tggcccagct gtatcgcgac aagacggccg ccgagggcgc cgtcgccggc gtctccgccg 2940
  tcctgagcac ggtgggggcg gcggtgtcga tcgccgcggc ggccagcgtg gtaggggccc 3000
  cggtggcggt ggtcacttcc ttgctgaccg gggctctcaa cggcatcctg cgcggcgtgc 3060
  agcagcccat catcgaaaag ctggccaacg attacgctcg caagatcgac gagctgggcg 3120
  ggccgcaagc gtacttcgag aaaaacctgc aggcgcgtca cgaacaactg gccaattcgg 3180
  acggcctacg gaaaatgctg gccgacctgc aggccggttg gaacgccagc agcgtgatcg 3240
  gggtgcagac gacagagatc tccaagtcgg cgctcgaact ggccgccatt accggcaacg 3300
  cggacaacct gaaatccgtc gacgtgttcg tggaccgctt cgtccagggc gagcgggtgg 3360
  ccggccagcc ggtggtcctc gacgtcgccg ccggcggcat cgatatcgcc agccgcaagg 3420
  gcgagcggcc ggcgctgacg ttcatcacgc cgctggccgc gccaggagaa gagcagcgcc 3480
  ggcgcacgaa aacgggcaag agcgaattca ccacattcgt cgagatcgtg ggcaagcagg 3540
  accgctggcg catccgggac ggcgcggccg acaccaccat cgatctggcc aaggtggtgt 3600
  cgcaactggt cgacgccaat ggcgtgctca agcacagcat caaactggat gtgatcggcg 3660
  gagatggcga tgacgtcgtg cttgccaatg cttcgcgcat ccattatgac ggcggcgcgg 3720
  gcaccaacac ggtcagctat gccgccctgg gtcgacagga ttccattacc gtgtccgccg 3780
  acggggaacg tttcaacgtg cgcaagcagt tgaacaacgc caacgtgtat cgcgaaggcg 3840
  tggctaccca gacaaccgcc tacggcaagc gcacggagaa tgtccaatac cgccatgtcg 3900
  agctggcccg tgtcgggcaa gtggtggagg tcgacacgct cgagcatgtg cagcacatca 3960
  tcggcggggc cggcaacgat tcgatcaccg gcaatgcgca cgacaacttc ctagccggcg 4020
  ggtcgggcga cgacaggctg gatggcggcg ccggcaacga caccctggtt ggcggcgagg 4080
  gccaaaacac ggtcatcggc ggcgccggcg acgacgtatt cctgcaggac ctgggggtat 4140
  ggagcaacca gctcgatggc ggcgcgggcg tcgataccgt gaagtacaac gtgcaccagc 4200
  cttccgagga gcgcctcgaa cgcatgggcg acacgggcat ccatgccgat cttcaaaagg 4260
  gcacggtcga gaagtggccg gccctgaacc tgttcagcgt cgaccatgtc aagaatatcg 4320
  agaatctgca cggctcccgc ctaaacgacc gcatcgccgg cgacgaccag gacaacgagc 4380
  tctggggcca cgatggcaac gacacgatac gcggccgggg cggcgacgac atcctgcgcg 4440
  gcggcctggg cctggacacg ctgtatggcg aggacggcaa cgacatcttc ctgcaggacg 4500
  acgagaccgt cagcgatgac atcgacggcg gcgcggggct ggacaccgtc gactactccg 4560
  ccatgatcca tccaggcagg atcgttgcgc cgcatgaata cggcttcggg atcgaggcgg 4620
  acctgtccag ggaatgggtg cgcaaggcgt ccgcgctggg cgtggactat tacgataatg 4680
  tccgcaatgt cgaaaacgtc atcggtacga gcatgaagga tgtgctcatc ggcgacgcgc 4740
  aagccaatac cctgatgggc cagggcggcg acgataccgt gcgcggcggc gacggcgatg 4800
  atctgctgtt cggcggcgac ggcaacgaca tgctgtatgg cgacgccggc aacgacaccc 4860
  tctacggggg gctgggcgac gatacccttg aaggcggcgc gggcaacgat tggttcggcc 4920
  agacgcaggc gcgcgagcat gacgtgctgc gcggcggaga tggggtggat accgtcgatt 4980
  acagccagac cggcgcgcat gccggcattg ccgcgggtcg catcgggctg ggcatcctgg 5040
  ctgacctggg cgccggccgc gtcgacaagc tgggcgaggc cggcagcagc gcctacgata 5100
  cggtttccgg tatcgagaac gtggtgggca cggaactggc cgaccgcatc acgggcgatg 5160
  cgcaggccaa cgtgctgcgc ggcgcgggtg gcgccgacgt gcttgcgggc ggcgagggcg 5220
  acgatgtgct gctgggcggc gacggcgacg accagctgtc gggcgacgcc ggacgcgatc 5280
  gcttgtacgg cgaagccggt gacgactggt tcttccagga tgccgccaat gccggcaatc 5340
  tgctcgacgg cggcgacggc cgcgataccg tggatttcag cggcccgggc cggggcctcg 5400
  acgccggcgc aaagggcgta ttcctgagct tgggcaaggg gttcgccagc ctgatggacg 5460
  aacccgaaac cagcaacgtg ttgcgcaata tcgagaacgc cgtgggcagc gcgcgtgatg 5520
  acgtgctgat cggcgacgca ggcgccaacg tcctcaatgg cctggcgggc aacgacgtgc 5580
  tgtccggcgg cgctggcgac gatgtgctgc tgggcgacga gggctcggac ctgctcagcg 5640
  gcgatgcggg caacgacgat ctgttcggcg ggcagggcga tgatacttat ctgttcgggg 5700
  tcgggtacgg gcacgacacg atctacgaat cgggcggcgg ccatgacacc atccgcatca 5760
  acgcgggggc ggaccagctg tggttcgcgc gccagggcaa cgacctggag atccgcattc 5820
  tcggcaccga cgatgcactt accgtgcacg actggtatcg cgacgccgat caccgggtgg 5880
  aaatcatcca tgccgccaac caggcggtag accaggcagg catcgaaaag ctggtcgagg 5940
  caatggcgca gtatccggac cccggcgcgg cggcggctgc cccgccggcg gcgcgcgtgc 6000
  cggacacgct gatgcagtcc ctggctgtca actggcgctg aagcgccgtg aatcacggcc 6060
  cgcctgcctc gcgcggcggc gccgtctctt tgcgttcttc tccgaggtat ttcccatcat 6120
  gacgtcgccc gcggcgcaat gcgccagcgt gcccgattcc gggttgctct gcctggtcat 6180
  gctggctcgc tatcacggat tggcagccga tcccgagcag ttgcggcatg agttcgccga 6240
  gaggcattct gtagcgaaac gatacagcct ggcggcgcgc cgggtcggcc tgaaagtgcg 6300
  gcggcaccga cccgcgccgg cgcggctgcc acgcgcgccg ctgccggcca tcgcgctgga 6360
  ccggtagggc ggctactttg tt                                          6382
  
  
  
  <210> 3
  <211> 800
  <212> PRT
  <213> Bacillus anthracis
  
  <400> 3
  Met Thr Arg Asn Lys Phe Ile Pro Asn Lys Phe Ser Ile Ile Ser Phe
   1               5                  10                  15      
  Ser Val Leu Leu Phe Ala Ile Ser Ser Ser Gln Ala Ile Glu Val Asn
              20                  25                  30          
  Ala Met Asn Glu His Tyr Thr Glu Ser Asp Ile Lys Arg Asn His Lys
          35                  40                  45              
  Thr Glu Lys Asn Lys Thr Glu Lys Glu Lys Phe Lys Asp Ser Ile Asn
      50                  55                  60                  
  Asn Leu Val Lys Thr Glu Phe Thr Asn Glu Thr Leu Asp Lys Ile Gln
  65                  70                  75                  80  
  Gln Thr Gln Asp Leu Leu Lys Lys Ile Pro Lys Asp Val Leu Glu Ile
                  85                  90                  95      
  Tyr Ser Glu Leu Gly Gly Glu Ile Tyr Phe Thr Asp Ile Asp Leu Val
              100                 105                 110         
  Glu His Lys Glu Leu Gln Asp Leu Ser Glu Glu Glu Lys Asn Ser Met
          115                 120                 125             
  Asn Ser Arg Gly Glu Lys Val Pro Phe Ala Ser Arg Phe Val Phe Glu
      130                 135                 140                 
  Lys Lys Arg Glu Thr Pro Lys Leu Ile Ile Asn Ile Lys Asp Tyr Ala
  145                 150                 155                 160 
  Ile Asn Ser Glu Gln Ser Lys Glu Val Tyr Tyr Glu Ile Gly Lys Gly
                  165                 170                 175     
  Ile Ser Leu Asp Ile Ile Ser Lys Asp Lys Ser Leu Asp Pro Glu Phe
              180                 185                 190         
  Leu Asn Leu Ile Lys Ser Leu Ser Asp Asp Ser Asp Ser Ser Asp Leu
          195                 200                 205             
  Leu Phe Ser Gln Lys Phe Lys Glu Lys Leu Glu Leu Asn Asn Lys Ser
      210                 215                 220                 
  Ile Asp Ile Asn Phe Ile Lys Glu Asn Leu Thr Glu Phe Gln His Ala
  225                 230                 235                 240 
  Phe Ser Leu Ala Phe Ser Tyr Tyr Phe Ala Pro Asp His Arg Thr Val
                  245                 250                 255     
  Leu Glu Leu Tyr Ala Pro Asp Met Phe Glu Tyr Met Asn Lys Leu Glu
              260                 265                 270         
  Lys Gly Gly Phe Glu Lys Ile Ser Glu Ser Leu Lys Lys Glu Gly Val
          275                 280                 285             
  Glu Lys Asp Arg Ile Asp Val Leu Lys Gly Glu Lys Ala Leu Lys Ala
      290                 295                 300                 
  Ser Gly Leu Val Pro Glu His Ala Asp Ala Phe Lys Lys Ile Ala Arg
  305                 310                 315                 320 
  Glu Leu Asn Thr Tyr Ile Leu Phe Arg Pro Val Asn Lys Leu Ala Thr
                  325                 330                 335     
  Asn Leu Ile Lys Ser Gly Val Ala Thr Lys Gly Leu Asn Glu His Gly
              340                 345                 350         
  Lys Ser Ser Asp Trp Gly Pro Val Ala Gly Tyr Ile Pro Phe Asp Gln
          355                 360                 365             
  Asp Leu Ser Lys Lys His Gly Gln Gln Leu Ala Val Glu Lys Gly Asn
      370                 375                 380                 
  Leu Glu Asn Lys Lys Ser Ile Thr Glu His Glu Gly Glu Ile Gly Lys
  385                 390                 395                 400 
  Ile Pro Leu Lys Leu Asp His Leu Arg Ile Glu Glu Leu Lys Glu Asn
                  405                 410                 415     
  Gly Ile Ile Leu Lys Gly Lys Lys Glu Ile Asp Asn Gly Lys Lys Tyr
              420                 425                 430          
  
  Tyr Leu Leu Glu Ser Asn Asn Gln Val Tyr Glu Phe Arg Ile Ser Asp
          435                 440                 445             
  Glu Asn Asn Glu Val Gln Tyr Lys Thr Lys Glu Gly Lys Ile Thr Val
      450                 455                 460                 
  Leu Gly Glu Lys Phe Asn Trp Arg Asn Ile Glu Val Met Ala Lys Asn
  465                 470                 475                 480 
  Val Glu Gly Val Leu Lys Pro Leu Thr Ala Asp Tyr Asp Leu Phe Ala
                  485                 490                 495     
  Leu Ala Pro Ser Leu Thr Glu Ile Lys Lys Gln Ile Pro Thr Lys Arg
              500                 505                 510         
  Met Asp Lys Val Val Asn Thr Pro Asn Ser Leu Glu Lys Gln Lys Gly
          515                 520                 525             
  Val Thr Asn Leu Leu Ile Lys Tyr Gly Ile Glu Arg Lys Pro Asp Ser
      530                 535                 540                 
  Thr Lys Gly Thr Leu Ser Asn Trp Gln Lys Gln Met Leu Asp Arg Leu
  545                 550                 555                 560 
  Asn Glu Ala Val Lys Tyr Thr Gly Tyr Thr Gly Gly Asp Val Val Asn
                  565                 570                 575     
  His Gly Thr Glu Gln Asp Asn Glu Glu Phe Pro Glu Lys Asp Asn Glu
              580                 585                 590         
  Ile Phe Ile Ile Asn Pro Glu Gly Glu Phe Ile Leu Thr Lys Asn Trp
          595                 600                 605             
  Glu Met Thr Gly Arg Phe Ile Glu Lys Asn Ile Thr Gly Lys Asp Tyr
      610                 615                 620                 
  Leu Tyr Tyr Phe Asn Arg Ser Tyr Asn Lys Ile Ala Pro Gly Asn Lys
  625                 630                 635                 640 
  Ala Tyr Ile Glu Trp Thr Asp Pro Ile Thr Lys Ala Lys Ile Asn Thr
                  645                 650                 655     
  Ile Pro Thr Ser Ala Glu Phe Ile Lys Asn Leu Ser Ser Ile Arg Arg
              660                 665                 670         
  Ser Ser Asn Val Gly Val Tyr Lys Asp Ser Gly Asp Lys Asp Glu Phe
          675                 680                 685             
  Ala Lys Lys Glu Ser Val Lys Lys Ile Ala Gly Tyr Leu Ser Asp Tyr
      690                 695                 700                 
  Tyr Asn Ser Ala Asn His Ile Phe Ser Gln Glu Lys Lys Arg Lys Ile
  705                 710                 715                 720 
  Ser Ile Phe Arg Gly Ile Gln Ala Tyr Asn Glu Ile Glu Asn Val Leu
                  725                 730                 735     
  
  Lys Ser Lys Gln Ile Ala Pro Glu Tyr Lys Asn Tyr Phe Gln Tyr Leu
              740                 745                 750         
  Lys Glu Arg Ile Thr Asn Gln Val Gln Leu Leu Leu Thr His Gln Lys
          755                 760                 765             
  Ser Asn Ile Glu Phe Lys Leu Leu Tyr Lys Gln Leu Asn Phe Thr Glu
      770                 775                 780                 
  Asn Glu Thr Asp Asn Phe Glu Val Phe Gln Lys Ile Ile Asp Glu Lys
  785                 790                 795                 800 
  
  
  <210> 4
  <211> 3420
  <212> DNA
  <213> Bacillus anthracis
  
  <400> 4
  ttactttttt atatactgaa ttaaaaagtc caagcactta tatcgtaata gatgctttct 60
  attgacctta tagtccttga agttacgact gaccaattat gagacgtttg cgctaacctg 120
  ctgaattcaa aatcggactt agaaatacac atatagaaat aaacaaccta atccatgtca 180
  ctgtaccgtt tttttactaa ataaacgaaa tcagtgtaaa aatgaacagc tgaactttat 240
  caacttagaa tctctttttt tactttaaat gcctagctgt tttttctaat gtttgtattt 300
  ctaaatatat ttaaatatga attgtagctg tgtgccaaga gttataatta atttaaataa 360
  gattatattt gtaaataaaa ttgtaattta acatgtagaa taaagagatt tttagtttta 420
  ttaacaggat gaaaatccat aaaaccgtaa atgtgatttc taaattagtt taaaataaaa 480
  aacaaggatt tgctcagact tgagatgaat atctaaatat caagaaccaa aggaggttta 540
  agaatgacta gaaataaatt tatacctaat aagtttagta ttatatcctt ttcagtatta 600
  ctatttgcta tatcctcctc acaggctata gaagtaaatg ctatgaatga acattacact 660
  gagagtgata ttaaaagaaa ccataaaact gaaaaaaata aaactgaaaa agaaaaattt 720
  aaagacagta ttaataactt agttaaaaca gaatttacca atgaaacttt agataaaata 780
  cagcagacac aagacttatt aaaaaagata cctaaggatg tacttgaaat ttatagtgaa 840
  ttaggaggag aaatctattt tacagatata gatttagtag aacataagga gttacaagat 900
  ttaagtgaag aagagaaaaa tagtatgaat agtagaggtg aaaaagttcc gtttgcatcc 960
  cgttttgtat ttgaaaagaa aagggaaaca cctaaattaa ttataaatat caaagattat 1020
  gcaattaata gtgaacaaag taaagaagta tattatgaaa ttggaaaggg gatttctctt 1080
  gatattataa gtaaggataa atctctagat ccagagtttt taaatttaat taagagttta 1140
  agcgatgata gtgatagtag cgacctttta tttagtcaaa aatttaaaga gaagctagaa 1200
  ttgaataata aaagtataga tataaatttt ataaaagaaa atttaactga atttcagcat 1260
  gcgttttctt tagcgttttc ttattatttt gcacctgacc atagaacggt attagagtta 1320
  tatgcccccg acatgtttga gtatatgaat aagttagaaa aagggggatt tgagaaaata 1380
  agtgaaagtt tgaagaaaga aggtgtggaa aaagatagga ttgatgtgct gaaaggagaa 1440
  aaagcactta aagcttcagg tttagtacca gaacatgcag atgcttttaa aaaaattgct 1500
  agagaattaa atacatatat tctttttagg cctgttaata agttagctac aaaccttatt 1560
  aaaagtggtg tggctacaaa gggattgaat gaacatggaa agagttcgga ttggggccct 1620
  gtagctggat acataccatt tgatcaagat ttatctaaga agcatggtca acaattagct 1680
  gtcgagaaag gaaatttaga aaataaaaaa tcaattacag agcatgaagg tgaaataggt 1740
  aaaataccat taaagttaga ccatttaaga atagaagagt taaaggaaaa tgggataatt 1800
  ttgaagggta aaaaagaaat tgataatggt aaaaaatatt atttgttaga atcgaataat 1860
  caggtatatg aatttagaat tagcgatgaa aacaacgaag tacaatacaa gacaaaagaa 1920
  ggtaaaatta ctgttttagg ggaaaaattc aattggagaa atatagaagt gatggctaaa 1980
  aatgtagaag gggtcttgaa gccgttaaca gctgactatg atttatttgc acttgcccca 2040
  agtttaacag aaataaaaaa acaaataccc acaaaaagaa tggataaagt agttaacacc 2100
  ccaaattcat tagaaaagca aaaaggtgtt actaatttat tgattaaata tggaattgag 2160
  aggaaaccgg attcaactaa gggaacttta tcaaattggc aaaaacaaat gcttgatcgt 2220
  ttgaatgaag cagtcaaata tacaggatat acaggggggg atgtggttaa ccatggcaca 2280
  gagcaagata atgaagagtt tcctgaaaaa gataacgaaa tttttataat taatccagaa 2340
  ggtgaattta tattaactaa aaattgggag atgacaggta gatttataga aaaaaacatt 2400
  acgggaaaag attatttata ttattttaac cgttcttata ataaaatagc tcctggtaat 2460
  aaagcttata ttgagtggac tgatccgatt acaaaagcca aaataaatac catccctacg 2520
  tcagcagagt ttataaaaaa cttatccagt atcagaagat cttcaaatgt aggagtttat 2580
  aaagatagtg gcgacaaaga cgaatttgca aaaaaagaaa gcgtgaaaaa aattgcagga 2640
  tatttgtcag actattacaa ttcagcaaat catatttttt ctcaggaaaa aaagcgtaaa 2700
  atatcaatat ttcgtggaat ccaagcctat aatgaaattg aaaatgttct aaaatctaaa 2760
  caaatagcac cagaatacaa aaattatttt caatatttaa aggaaaggat taccaatcaa 2820
  gttcaattgc ttctaacaca tcaaaaatct aatattgaat ttaaattatt gtataaacaa 2880
  ttaaacttta cagaaaatga aacggataat tttgaggtct tccaaaaaat tattgatgaa 2940
  aaataaatat atataattgt ttttctgaaa attcatcatt ttaaagaaga cactaggaat 3000
  taaatagatg tattgaatag ttatagtaat ggtcttgtat ggacataccg cttatacttt 3060
  gggaggtagt agatattaaa caacatatag caaatgaact ggagtgtaga tcaaaagaaa 3120
  tttttctaaa aaatatctca tctttaataa aaaatggcac tgtatataaa gcagcaacag 3180
  ataaaattat tacctatatg caaaagattt aaatattgac cttgtaatag gcatggaatc 3240
  tcgagggttt atttttggtt gcccagtttc atatgctttg ggaataggtt ttataccggt 3300
  tcgtaaatta gggaccctgg ttggatttga taatgagaac gtaaaagata ttctaacaat 3360
  aaataatgat gcgattaacc aggccacgtg tgttaatact gatgtatgtg taactactgg 3420
  
  
  
  
  
  <210> 5
  <211> 800
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic adenylate cyclase.
  
  <400> 5
  Met Thr Arg Asn Lys Phe Ile Pro Asn Lys Phe Ser Ile Ile Ser Phe
   1               5                  10                  15      
  Ser Val Leu Leu Phe Ala Ile Ser Ser Ser Gln Ala Ile Glu Val Asn
              20                  25                  30          
  Ala Met Asn Glu His Tyr Thr Glu Ser Asp Ile Lys Arg Asn His Lys
          35                  40                  45              
  Thr Glu Lys Asn Lys Thr Glu Lys Glu Lys Phe Lys Asp Ser Ile Asn
      50                  55                  60                  
  Asn Leu Val Lys Thr Glu Phe Thr Asn Glu Thr Leu Asp Lys Ile Gln
  65                  70                  75                  80  
  Gln Thr Gln Asp Leu Leu Lys Lys Ile Pro Lys Asp Val Leu Glu Ile
                  85                  90                  95      
  Tyr Ser Glu Leu Gly Gly Glu Ile Tyr Phe Thr Asp Ile Asp Leu Val
              100                 105                 110         
  Glu His Lys Glu Leu Gln Asp Leu Ser Glu Glu Glu Lys Asn Ser Met
          115                 120                 125             
  Asn Ser Arg Gly Glu Lys Val Pro Phe Ala Ser Arg Phe Val Phe Glu
      130                 135                 140                 
  Lys Lys Arg Glu Thr Pro Lys Leu Ile Ile Asn Ile Lys Asp Tyr Ala
  145                 150                 155                 160 
  Ile Asn Ser Glu Gln Ser Lys Glu Val Tyr Tyr Glu Ile Gly Lys Gly
                  165                 170                 175     
  Ile Ser Leu Asp Ile Ile Ser Lys Asp Lys Ser Leu Asp Pro Glu Phe
              180                 185                 190         
  Leu Asn Leu Ile Lys Ser Leu Ser Asp Asp Ser Asp Ser Ser Asp Leu
          195                 200                 205             
  Leu Phe Ser Gln Lys Phe Lys Glu Lys Leu Glu Leu Asn Asn Lys Ser
      210                 215                 220                 
  Ile Asp Ile Asn Phe Ile Lys Glu Asn Leu Thr Glu Phe Gln His Ala
  225                 230                 235                 240 
  Phe Ser Leu Ala Phe Ser Tyr Tyr Phe Ala Pro Asp His Arg Thr Val
                  245                 250                 255     
  Leu Glu Leu Tyr Ala Pro Asp Met Phe Glu Tyr Met Asn Lys Leu Glu
              260                 265                 270         
  Lys Gly Gly Phe Glu Lys Ile Ser Glu Ser Leu Lys Lys Glu Gly Val
          275                 280                 285             
  Glu Lys Asp Arg Ile Asp Val Leu Lys Gly Glu Lys Ala Leu Lys Ala
      290                 295                 300                 
  Ser Gly Leu Val Pro Glu His Ala Asp Ala Phe Lys Lys Ile Ala Arg
  305                 310                 315                 320 
  Glu Leu Asn Thr Tyr Ile Leu Phe Arg Pro Val Asn Lys Leu Ala Thr
                  325                 330                 335     
  Asn Leu Ile Lys Ser Gly Val Ala Thr Lys Gly Leu Asn Val His Gly
              340                 345                 350         
  Lys Ser Ser Asp Trp Gly Pro Val Ala Gly Tyr Ile Pro Phe Asp Gln
          355                 360                 365             
  Asp Leu Ser Lys Lys His Gly Gln Gln Leu Ala Val Glu Lys Gly Asn
      370                 375                 380                 
  Leu Glu Asn Lys Lys Ser Ile Thr Glu His Glu Gly Glu Ile Gly Lys
  385                 390                 395                 400 
  Ile Pro Leu Lys Leu Asp His Leu Arg Ile Glu Glu Leu Lys Glu Asn
                  405                 410                 415     
  Gly Ile Ile Leu Lys Gly Lys Lys Glu Ile Asp Asn Gly Lys Lys Tyr
              420                 425                 430         
  Tyr Leu Leu Glu Ser Asn Asn Gln Val Tyr Glu Phe Arg Ile Ser Asp
          435                 440                 445             
  Glu Asn Asn Glu Val Gln Tyr Lys Thr Lys Glu Gly Lys Ile Thr Val
      450                 455                 460                 
  Leu Gly Glu Lys Phe Asn Trp Arg Asn Ile Glu Val Met Ala Lys Asn
  465                 470                 475                 480 
  Val Glu Gly Val Leu Lys Pro Leu Thr Ala Asp Tyr Asp Leu Phe Ala
                  485                 490                 495     
  Leu Ala Pro Ser Leu Thr Glu Ile Lys Lys Gln Ile Pro Gln Lys Glu
              500                 505                 510         
  Trp Asp Lys Val Val Asn Thr Pro Asn Ser Leu Glu Lys Gln Lys Gly
          515                 520                 525             
  Val Thr Asn Leu Leu Ile Lys Tyr Gly Ile Glu Arg Lys Pro Asp Ser
      530                 535                 540                  
  
  Thr Lys Gly Thr Leu Ser Asn Trp Gln Lys Gln Met Leu Asp Arg Leu
  545                 550                 555                 560 
  Asn Glu Ala Val Lys Tyr Thr Gly Tyr Thr Gly Gly Asp Val Val Asn
                  565                 570                 575     
  His Gly Thr Glu Gln Asp Asn Glu Glu Phe Pro Glu Lys Asp Asn Glu
              580                 585                 590         
  Ile Phe Ile Ile Asn Pro Glu Gly Glu Phe Ile Leu Thr Lys Asn Trp
          595                 600                 605             
  Glu Met Thr Gly Arg Phe Ile Glu Lys Asn Ile Thr Gly Lys Asp Tyr
      610                 615                 620                 
  Leu Tyr Tyr Phe Asn Arg Ser Tyr Asn Lys Ile Ala Pro Gly Asn Lys
  625                 630                 635                 640 
  Ala Tyr Ile Glu Trp Thr Asp Pro Ile Thr Lys Ala Lys Ile Asn Thr
                  645                 650                 655     
  Ile Pro Thr Ser Ala Glu Phe Ile Lys Asn Leu Ser Ser Ile Arg Arg
              660                 665                 670         
  Ser Ser Asn Val Gly Val Tyr Lys Asp Ser Gly Asp Lys Asp Glu Phe
          675                 680                 685             
  Ala Lys Lys Glu Ser Val Lys Lys Ile Ala Gly Tyr Leu Ser Asp Tyr
      690                 695                 700                 
  Tyr Asn Ser Ala Asn His Ile Phe Ser Gln Glu Lys Lys Arg Lys Ile
  705                 710                 715                 720 
  Ser Ile Phe Arg Gly Ile Gln Ala Tyr Asn Glu Ile Glu Asn Val Leu
                  725                 730                 735     
  Lys Ser Lys Gln Ile Ala Pro Glu Tyr Lys Asn Tyr Phe Gln Tyr Leu
              740                 745                 750         
  Lys Glu Arg Ile Thr Asn Gln Val Gln Leu Leu Leu Thr His Gln Lys
          755                 760                 765             
  Ser Asn Ile Glu Phe Lys Leu Leu Tyr Lys Gln Leu Asn Phe Thr Glu
      770                 775                 780                 
  Asn Glu Thr Asp Asn Phe Glu Val Phe Gln Lys Ile Ile Asp Glu Lys
  785                 790                 795                 800 
  
  
  <210> 6
  <211> 800
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic adenylate cyclase.
  
  <400> 6
  Met Thr Arg Asn Lys Phe Ile Pro Asn Lys Phe Ser Ile Ile Ser Phe
   1               5                  10                  15      
  Ser Val Leu Leu Phe Ala Ile Ser Ser Ser Gln Ala Ile Glu Val Asn
              20                  25                  30          
  Ala Met Asn Glu His Tyr Thr Glu Ser Asp Ile Lys Arg Asn His Lys
          35                  40                  45              
  Thr Glu Lys Asn Lys Thr Glu Lys Glu Lys Phe Lys Asp Ser Ile Asn
      50                  55                  60                  
  Asn Leu Val Lys Thr Glu Phe Thr Asn Glu Thr Leu Asp Lys Ile Gln
  65                  70                  75                  80  
  Gln Thr Gln Asp Leu Leu Lys Lys Ile Pro Lys Asp Val Leu Glu Ile
                  85                  90                  95      
  Tyr Ser Glu Leu Gly Gly Glu Ile Tyr Phe Thr Asp Ile Asp Leu Val
              100                 105                 110         
  Glu His Lys Glu Leu Gln Asp Leu Ser Glu Glu Glu Lys Asn Ser Met
          115                 120                 125             
  Asn Ser Arg Gly Glu Lys Val Pro Phe Ala Ser Arg Phe Val Phe Glu
      130                 135                 140                 
  Lys Lys Arg Glu Thr Pro Lys Leu Ile Ile Asn Ile Lys Asp Tyr Ala
  145                 150                 155                 160 
  Ile Asn Ser Glu Gln Ser Lys Glu Val Tyr Tyr Glu Ile Gly Lys Gly
                  165                 170                 175     
  Ile Ser Leu Asp Ile Ile Ser Lys Asp Lys Ser Leu Asp Pro Glu Phe
              180                 185                 190         
  Leu Asn Leu Ile Lys Ser Leu Ser Asp Asp Ser Asp Ser Ser Asp Leu
          195                 200                 205             
  Leu Phe Ser Gln Lys Phe Lys Glu Lys Leu Glu Leu Asn Asn Lys Ser
      210                 215                 220                 
  Ile Asp Ile Asn Phe Ile Lys Glu Asn Leu Thr Glu Phe Gln His Ala
  225                 230                 235                 240 
  Phe Ser Leu Ala Phe Ser Tyr Tyr Phe Ala Pro Asp His Arg Thr Val
                  245                 250                 255     
  Leu Glu Leu Tyr Ala Pro Asp Met Phe Glu Tyr Met Asn Lys Leu Glu
              260                 265                 270          
  
  Lys Gly Gly Phe Glu Lys Ile Ser Glu Ser Leu Lys Lys Glu Gly Val
          275                 280                 285             
  Glu Lys Asp Arg Ile Asp Val Leu Lys Gly Glu Lys Ala Leu Lys Ala
      290                 295                 300                 
  Ser Gly Leu Val Pro Glu His Ala Asp Ala Phe Lys Lys Ile Ala Arg
  305                 310                 315                 320 
  Glu Leu Asn Thr Tyr Ile Leu Phe Arg Pro Val Asn Lys Leu Ala Thr
                  325                 330                 335     
  Asn Leu Ile Lys Ser Gly Val Ala Thr Lys Gly Leu Asn Val His Gly
              340                 345                 350         
  Lys Ser Ser Asp Trp Gly Pro Val Ala Gly Tyr Ile Pro Phe Asp Gln
          355                 360                 365             
  Asp Leu Ser Lys Lys His Gly Gln Gln Leu Ala Val Glu Lys Gly Asn
      370                 375                 380                 
  Leu Glu Asn Lys Lys Ser Ile Thr Glu His Glu Gly Glu Ile Gly Lys
  385                 390                 395                 400 
  Ile Pro Leu Lys Leu Asp His Leu Arg Ile Glu Glu Leu Lys Glu Asn
                  405                 410                 415     
  Gly Ile Ile Leu Lys Gly Lys Lys Glu Ile Asp Asn Gly Lys Lys Tyr
              420                 425                 430         
  Tyr Leu Leu Glu Ser Asn Asn Gln Val Tyr Glu Phe Arg Ile Ser Asp
          435                 440                 445             
  Glu Asn Asn Glu Val Gln Tyr Lys Thr Lys Glu Gly Lys Ile Thr Val
      450                 455                 460                 
  Leu Gly Glu Lys Phe Asn Trp Arg Asn Ile Glu Val Met Ala Lys Asn
  465                 470                 475                 480 
  Val Glu Gly Val Leu Lys Pro Leu Thr Ala Asp Tyr Asp Leu Phe Ala
                  485                 490                 495     
  Leu Ala Pro Ser Leu Thr Glu Ile Lys Lys Gln Ile Pro Gln Lys Glu
              500                 505                 510         
  Trp Asp Lys Val Val Asn Thr Pro Asn Ser Leu Glu Lys Gln Lys Gly
          515                 520                 525             
  Val Thr Asn Leu Leu Ile Lys Tyr Gly Ile Glu Arg Lys Pro Asp Ser
      530                 535                 540                 
  Thr Lys Gly Thr Leu Ser Asn Trp Gln Lys Gln Met Leu Asp Arg Leu
  545                 550                 555                 560 
  Asn Glu Ala Val Lys Tyr Thr Gly Tyr Thr Gly Gly Asp Val Val Asn
                  565                 570                 575     
  
  His Gly Thr Glu Gln Asp Asn Glu Glu Phe Pro Glu Lys Asp Asn Glu
              580                 585                 590         
  Ile Phe Ile Ile Asn Pro Glu Gly Glu Phe Ile Leu Thr Lys Asn Trp
          595                 600                 605             
  Glu Met Thr Gly Arg Phe Ile Glu Lys Asn Ile Thr Gly Lys Asp Tyr
      610                 615                 620                 
  Leu Tyr Tyr Phe Asn Arg Ser Tyr Asn Lys Ile Ala Pro Gly Asn Lys
  625                 630                 635                 640 
  Ala Tyr Ile Glu Trp Thr Asp Pro Ile Thr Lys Ala Lys Ile Asn Thr
                  645                 650                 655     
  Ile Pro Thr Ser Ala Glu Phe Ile Lys Asn Leu Ser Ser Ile Arg Arg
              660                 665                 670         
  Ser Ser Asn Val Gly Val Tyr Lys Asp Ser Gly Asp Lys Asp Glu Phe
          675                 680                 685             
  Ala Lys Lys Glu Ser Val Lys Lys Ile Ala Gly Tyr Leu Ser Asp Tyr
      690                 695                 700                 
  Tyr Asn Ser Ala Asn His Ile Phe Ser Gln Glu Lys Lys Arg Lys Ile
  705                 710                 715                 720 
  Ser Ile Phe Arg Gly Ile Gln Ala Tyr Asn Glu Ile Glu Asn Val Leu
                  725                 730                 735     
  Lys Ser Lys Gln Ile Ala Pro Glu Tyr Lys Asn Tyr Phe Gln Tyr Leu
              740                 745                 750         
  Lys Glu Arg Ile Thr Asn Gln Val Gln Leu Leu Leu Thr His Gln Lys
          755                 760                 765             
  Ser Asn Ile Glu Phe Lys Leu Leu Tyr Lys Gln Leu Asn Phe Thr Glu
      770                 775                 780                 
  Asn Glu Thr Asp Asn Phe Glu Val Phe Gln Lys Ile Ile Asp Glu Lys
  785                 790                 795                 800 
  
  
  <210> 7
  <211> 433
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic adenylate cyclase.
  
  
  <400> 7
  Met Ala Gln Glu Ile Glu Leu Lys Phe Ile Val Asn His Ser Ala Val
   1               5                  10                  15      
  Glu Ala Leu Arg Asp His Leu Asn Thr Leu Gly Gly Glu His His Asp
              20                  25                  30          
  Pro Val Gln Leu Leu Asn Ile Tyr Tyr Glu Thr Pro Asp Asn Trp Leu
          35                  40                  45              
  Arg Gly His Asp Met Gly Leu Arg Ile Arg Gly Glu Asn Gly Arg Tyr
      50                  55                  60                  
  Glu Met Thr Met Lys Val Ala Gly Arg Val Thr Gly Gly Leu His Gln
  65                  70                  75                  80  
  Arg Pro Glu Tyr Asn Val Ala Leu Ser Glu Pro Thr Leu Asp Leu Ala
                  85                  90                  95      
  Gln Leu Pro Thr Glu Val Trp Pro Asn Gly Glu Leu Pro Ala Asp Leu
              100                 105                 110         
  Ala Ser Arg Val Gln Pro Leu Phe Ser Thr Asp Phe Tyr Arg Glu Lys
          115                 120                 125             
  Trp Leu Val Ala Val Asp Gly Ser Gln Ile Glu Ile Ala Leu Asp Gln
      130                 135                 140                 
  Gly Glu Val Lys Ala Gly Glu Phe Ala Glu Pro Ile Cys Glu Leu Glu
  145                 150                 155                 160 
  Leu Glu Leu Leu Ser Gly Asp Thr Arg Ala Val Leu Lys Leu Ala Asn
                  165                 170                 175     
  Gln Leu Val Ser Gln Thr Gly Leu Arg Gln Gly Ser Leu Ser Lys Ala
              180                 185                 190         
  Ala Arg Gly Tyr His Leu Ala Gln Gly Asn Pro Ala Arg Glu Ile Lys
          195                 200                 205             
  Pro Thr Thr Ile Leu His Val Ala Ala Lys Ala Asp Val Glu Gln Gly
      210                 215                 220                 
  Leu Glu Ala Ala Leu Glu Leu Ala Leu Ala Gln Trp Gln Tyr His Glu
  225                 230                 235                 240 
  Glu Leu Trp Val Arg Gly Asn Asp Ala Ala Lys Glu Gln Val Leu Ala
                  245                 250                 255     
  Ala Ile Ser Leu Val Arg His Thr Leu Met Leu Phe Gly Gly Ile Val
              260                 265                 270         
  Pro Arg Lys Ala Ser Thr His Leu Arg Asp Leu Leu Thr Gln Cys Glu
          275                 280                 285             
  Ala Thr Ile Ala Ser Ala Val Ser Ala Val Thr Ala Val Tyr Ser Thr
      290                 295                 300                 
  Glu Thr Ala Met Ala Lys Leu Ala Leu Thr Glu Trp Leu Val Ser Lys
  305                 310                 315                 320 
  Ala Trp Gln Pro Phe Leu Asp Ala Lys Ala Gln Gly Lys Ile Ser Asp
                  325                 330                 335     
  Ser Phe Lys Arg Phe Ala Asp Ile His Leu Ser Arg His Ala Ala Glu
              340                 345                 350         
  Leu Lys Ser Val Phe Cys Gln Pro Leu Gly Asp Arg Tyr Arg Asp Gln
          355                 360                 365             
  Leu Pro Arg Leu Thr Arg Asp Ile Asp Ser Ile Leu Leu Leu Ala Gly
      370                 375                 380                 
  Tyr Tyr Asp Pro Val Val Ala Gln Ala Trp Leu Glu Asn Trp Gln Gly
  385                 390                 395                 400 
  Leu His His Ala Ile Ala Thr Gly Gln Arg Ile Glu Ile Glu His Phe
                  405                 410                 415     
  Arg Asn Glu Ala Asn Asn Gln Glu Pro Phe Trp Leu His Ser Gly Lys
              420                 425                 430         
  Arg
      
  
  
  <210> 8
  <211> 1706
  <212> PRT
  <213> Bordetella pertussis
  
  <400> 8
  Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu
   1               5                  10                  15      
  Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys
              20                  25                  30          
  Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr
          35                  40                  45              
  Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala
      50                  55                  60                  
  Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro
  65                  70                  75                  80  
  Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala
                  85                  90                  95       
  
  Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp
              100                 105                 110         
  Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu
          115                 120                 125             
  Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr
      130                 135                 140                 
  Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala
  145                 150                 155                 160 
  Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val
                  165                 170                 175     
  Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe
              180                 185                 190         
  Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser
          195                 200                 205             
  Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg
      210                 215                 220                 
  Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu
  225                 230                 235                 240 
  Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu
                  245                 250                 255     
  Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile
              260                 265                 270         
  Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His
          275                 280                 285             
  Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn
      290                 295                 300                 
  Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly
  305                 310                 315                 320 
  Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln
                  325                 330                 335     
  Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val
              340                 345                 350         
  Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val
          355                 360                 365             
  Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro
      370                 375                 380                 
  Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln
  385                 390                 395                 400 
  
  Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser
                  405                 410                 415     
  Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu
              420                 425                 430         
  Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu
          435                 440                 445             
  Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln
      450                 455                 460                 
  Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala
  465                 470                 475                 480 
  Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu
                  485                 490                 495     
  Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser
              500                 505                 510         
  Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp
          515                 520                 525             
  Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly
      530                 535                 540                 
  Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro
  545                 550                 555                 560 
  Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr
                  565                 570                 575     
  Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala
              580                 585                 590         
  Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly
          595                 600                 605             
  Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr
      610                 615                 620                 
  Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala
  625                 630                 635                 640 
  Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln
                  645                 650                 655     
  Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser
              660                 665                 670         
  Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala
          675                 680                 685             
  Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly
      690                 695                 700                  
  
  Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys
  705                 710                 715                 720 
  Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln
                  725                 730                 735     
  Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn
              740                 745                 750         
  Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn
          755                 760                 765             
  Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala
      770                 775                 780                 
  Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val
  785                 790                 795                 800 
  Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln
                  805                 810                 815     
  Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg
              820                 825                 830         
  Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro
          835                 840                 845             
  Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr
      850                 855                 860                 
  Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp
  865                 870                 875                 880 
  Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu
                  885                 890                 895     
  Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val Ile
              900                 905                 910         
  Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His
          915                 920                 925             
  Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly
      930                 935                 940                 
  Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val
  945                 950                 955                 960 
  Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr
                  965                 970                 975     
  Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His
              980                 985                 990         
  Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp Thr Leu Glu
          995                 1000                1005            
  
  His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser Ile Thr Gly
      1010                1015                1020                
  Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser Gly Asp Asp Arg Leu
  1025                1030                1035                1040
  Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu Gly Gln Asn
                  1045                1050                1055    
  Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe Leu Gln Asp Leu Gly
              1060                1065                1070        
  Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp Thr Val Lys
          1075                1080                1085            
  Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu Glu Arg Met Gly Asp
      1090                1095                1100                
  Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr Val Glu Lys Trp Pro
  1105                1110                1115                1120
  Ala Leu Asn Leu Phe Ser Val Asp His Val Lys Asn Ile Glu Asn Leu
                  1125                1130                1135    
  His Gly Ser Arg Leu Asn Asp Arg Ile Ala Gly Asp Asp Gln Asp Asn
              1140                1145                1150        
  Glu Leu Trp Gly His Asp Gly Asn Asp Thr Ile Arg Gly Arg Gly Gly
          1155                1160                1165            
  Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp Thr Leu Tyr Gly Glu
      1170                1175                1180                
  Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu Thr Val Ser Asp Asp
  1185                1190                1195                1200
  Ile Asp Gly Gly Ala Gly Leu Asp Thr Val Asp Tyr Ser Ala Met Ile
                  1205                1210                1215    
  His Pro Gly Arg Ile Val Ala Pro His Glu Tyr Gly Phe Gly Ile Glu
              1220                1225                1230        
  Ala Asp Leu Ser Arg Glu Trp Val Arg Lys Ala Ser Ala Leu Gly Val
          1235                1240                1245            
  Asp Tyr Tyr Asp Asn Val Arg Asn Val Glu Asn Val Ile Gly Thr Ser
      1250                1255                1260                
  Met Lys Asp Val Leu Ile Gly Asp Ala Gln Ala Asn Thr Leu Met Gly
  1265                1270                1275                1280
  Gln Gly Gly Asp Asp Thr Val Arg Gly Gly Asp Gly Asp Asp Leu Leu
                  1285                1290                1295    
  Phe Gly Gly Asp Gly Asn Asp Met Leu Tyr Gly Asp Ala Gly Asn Asp
              1300                1305                1310              
  
  Thr Leu Tyr Gly Gly Leu Gly Asp Asp Thr Leu Glu Gly Gly Ala Gly
          1315                1320                1325            
  Asn Asp Trp Phe Gly Gln Thr Gln Ala Arg Glu His Asp Val Leu Arg
      1330                1335                1340                
  Gly Gly Asp Gly Val Asp Thr Val Asp Tyr Ser Gln Thr Gly Ala His
  1345                1350                1355                1360
  Ala Gly Ile Ala Ala Gly Arg Ile Gly Leu Gly Ile Leu Ala Asp Leu
                  1365                1370                1375    
  Gly Ala Gly Arg Val Asp Lys Leu Gly Glu Ala Gly Ser Ser Ala Tyr
              1380                1385                1390        
  Asp Thr Val Ser Gly Ile Glu Asn Val Val Gly Thr Glu Leu Ala Asp
          1395                1400                1405            
  Arg Ile Thr Gly Asp Ala Gln Ala Asn Val Leu Arg Gly Ala Gly Gly
      1410                1415                1420                
  Ala Asp Val Leu Ala Gly Gly Glu Gly Asp Asp Val Leu Leu Gly Gly
  1425                1430                1435                1440
  Asp Gly Asp Asp Gln Leu Ser Gly Asp Ala Gly Arg Asp Arg Leu Tyr
                  1445                1450                1455    
  Gly Glu Ala Gly Asp Asp Trp Phe Phe Gln Asp Ala Ala Asn Ala Gly
              1460                1465                1470        
  Asn Leu Leu Asp Gly Gly Asp Gly Arg Asp Thr Val Asp Phe Ser Gly
          1475                1480                1485            
  Pro Gly Arg Gly Leu Asp Ala Gly Ala Lys Gly Val Phe Leu Ser Leu
      1490                1495                1500                
  Gly Lys Gly Phe Ala Ser Leu Met Asp Glu Pro Glu Thr Ser Asn Val
  1505                1510                1515                1520
  Leu Arg Asn Ile Glu Asn Ala Val Gly Ser Ala Arg Asp Asp Val Leu
                  1525                1530                1535    
  Ile Gly Asp Ala Gly Ala Asn Val Leu Asn Gly Leu Ala Gly Asn Asp
              1540                1545                1550        
  Val Leu Ser Gly Gly Ala Gly Asp Asp Val Leu Leu Gly Asp Glu Gly
          1555                1560                1565            
  Ser Asp Leu Leu Ser Gly Asp Ala Gly Asn Asp Asp Leu Phe Gly Gly
      1570                1575                1580                
  Gln Gly Asp Asp Thr Tyr Leu Phe Gly Val Gly Tyr Gly His Asp Thr
  1585                1590                1595                1600
  Ile Tyr Glu Ser Gly Gly Gly His Asp Thr Ile Arg Ile Asn Ala Gly
                  1605                1610                1615          
  
  Ala Asp Gln Leu Trp Phe Ala Arg Gln Gly Asn Asp Leu Glu Ile Arg
              1620                1625                1630        
  Ile Leu Gly Thr Asp Asp Ala Leu Thr Val His Asp Trp Tyr Arg Asp
          1635                1640                1645            
  Ala Asp His Arg Val Glu Ile Ile His Ala Ala Asn Gln Ala Val Asp
      1650                1655                1660                
  Gln Ala Gly Ile Glu Lys Leu Val Glu Ala Met Ala Gln Tyr Pro Asp
  1665                1670                1675                1680
  Pro Gly Ala Ala Ala Ala Ala Pro Pro Ala Ala Arg Val Pro Asp Thr
                  1685                1690                1695    
  Leu Met Gln Ser Leu Ala Val Asn Trp Arg
              1700                1705    
  
  
  <210> 9
  <211> 1706
  <212> PRT
  <213> Bordetella bronchiseptica
  
  <400> 9
  Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu
   1               5                  10                  15      
  Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys
              20                  25                  30          
  Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr
          35                  40                  45              
  Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala
      50                  55                  60                  
  Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro
  65                  70                  75                  80  
  Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala
                  85                  90                  95      
  Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp
              100                 105                 110         
  Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu
          115                 120                 125             
  Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr
      130                 135                 140                 
  
  Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala
  145                 150                 155                 160 
  Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val
                  165                 170                 175     
  Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe
              180                 185                 190         
  Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser
          195                 200                 205             
  Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg
      210                 215                 220                 
  Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu
  225                 230                 235                 240 
  Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu
                  245                 250                 255     
  Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile
              260                 265                 270         
  Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His
          275                 280                 285             
  Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn
      290                 295                 300                 
  Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly
  305                 310                 315                 320 
  Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln
                  325                 330                 335     
  Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val
              340                 345                 350         
  Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val
          355                 360                 365             
  Pro Gly Gly Arg Ser Lys Ser Ser Pro Asp Val Leu Glu Thr Val Pro
      370                 375                 380                 
  Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln
  385                 390                 395                 400 
  Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser
                  405                 410                 415     
  Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu
              420                 425                 430         
  Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu
          435                 440                 445             
  
  Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln
      450                 455                 460                 
  Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala
  465                 470                 475                 480 
  Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu
                  485                 490                 495     
  Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser
              500                 505                 510         
  Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp
          515                 520                 525             
  Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly
      530                 535                 540                 
  Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro
  545                 550                 555                 560 
  Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr
                  565                 570                 575     
  Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala
              580                 585                 590         
  Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly
          595                 600                 605             
  Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr
      610                 615                 620                 
  Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala
  625                 630                 635                 640 
  Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln
                  645                 650                 655     
  Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser
              660                 665                 670         
  Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala
          675                 680                 685             
  Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly
      690                 695                 700                 
  Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys
  705                 710                 715                 720 
  Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln
                  725                 730                 735     
  Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn
              740                 745                 750         
  
  Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn
          755                 760                 765             
  Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala
      770                 775                 780                 
  Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Ala
  785                 790                 795                 800 
  Asp Val Phe Val Asp Arg Phe Ile Gln Gly Glu Arg Val Ala Gly Gln
                  805                 810                 815     
  Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg
              820                 825                 830         
  Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro
          835                 840                 845             
  Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr
      850                 855                 860                 
  Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp
  865                 870                 875                 880 
  Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu
                  885                 890                 895     
  Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Glu Val Ile
              900                 905                 910         
  Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His
          915                 920                 925             
  Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly
      930                 935                 940                 
  Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val
  945                 950                 955                 960 
  Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr
                  965                 970                 975     
  Gln Lys Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His
              980                 985                 990         
  Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp Thr Leu Glu
          995                 1000                1005            
  His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser Ile Thr Gly
      1010                1015                1020                
  Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ala Gly Asp Asp Arg Leu
  1025                1030                1035                1040
  Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu Gly His Asn
                  1045                1050                1055    
  
  Thr Val Val Gly Gly Ala Gly Asp Asp Val Phe Leu Gln Asp Leu Gly
              1060                1065                1070        
  Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp Thr Val Lys
          1075                1080                1085            
  Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu Glu Arg Met Gly Asp
      1090                1095                1100                
  Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr Val Glu Lys Trp Pro
  1105                1110                1115                1120
  Ala Leu Asn Leu Phe Ser Val Asp His Val Lys Asn Ile Glu Asn Leu
                  1125                1130                1135    
  His Gly Ser Ser Leu Asn Asp Ser Ile Ala Gly Asp Asp Arg Asp Asn
              1140                1145                1150        
  Glu Leu Trp Gly Asp Asp Gly Asn Asp Thr Ile His Gly Arg Gly Gly
          1155                1160                1165            
  Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp Thr Leu Tyr Gly Glu
      1170                1175                1180                
  Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu Thr Val Ser Asp Asp
  1185                1190                1195                1200
  Ile Asp Gly Gly Ala Gly Leu Asp Thr Val Asp Tyr Ser Ala Met Ile
                  1205                1210                1215    
  His Ala Gly Lys Ile Val Ala Pro His Glu Tyr Gly Phe Gly Ile Glu
              1220                1225                1230        
  Ala Asp Leu Ser Glu Gly Trp Val Arg Lys Ala Ala Arg Arg Gly Met
          1235                1240                1245            
  Asp Tyr Tyr Asp Ser Val Arg Ser Val Glu Asn Val Ile Gly Thr Ser
      1250                1255                1260                
  Met Lys Asp Val Leu Ile Gly Asp Ala Gln Ala Asn Thr Leu Met Gly
  1265                1270                1275                1280
  Gln Gly Gly Asp Asp Thr Val Arg Gly Gly Asp Gly Asp Asp Leu Leu
                  1285                1290                1295    
  Phe Gly Gly Asp Gly Asn Asp Met Leu Tyr Gly Asp Ala Gly Asn Asp
              1300                1305                1310        
  Thr Leu Tyr Gly Gly Leu Gly Asp Asp Thr Leu Glu Gly Gly Ala Gly
          1315                1320                1325            
  Asn Asp Trp Phe Gly Gln Thr Pro Ala Arg Glu His Asp Val Leu Arg
      1330                1335                1340                
  Gly Gly Ala Gly Val Asp Thr Val Asp Tyr Ser Gln Ala Gly Ala His
  1345                1350                1355                1360 
  
  Ala Gly Val Ala Thr Gly Arg Ile Gly Leu Gly Ile Leu Ala Asp Leu
                  1365                1370                1375    
  Gly Ala Gly Arg Val Asp Lys Leu Gly Glu Ala Gly Ser Ser Ala Tyr
              1380                1385                1390        
  Asp Thr Val Ser Gly Ile Glu Asn Val Val Gly Thr Glu Leu Ala Asp
          1395                1400                1405            
  Arg Ile Thr Gly Asp Ala Gln Ala Asn Val Leu Arg Gly Ala Gly Gly
      1410                1415                1420                
  Ala Asp Val Leu Ala Gly Gly Glu Gly Asp Asp Val Leu Leu Gly Gly
  1425                1430                1435                1440
  Asp Gly Asp Asp Gln Leu Ser Gly Asp Ala Gly Arg Asp Arg Leu Tyr
                  1445                1450                1455    
  Gly Glu Ala Gly Asp Asp Trp Phe Phe Gln Asp Ala Ala Asn Ala Gly
              1460                1465                1470        
  Asn Leu Leu Asp Gly Gly Asp Gly Asn Asp Thr Val Asp Phe Ser Gly
          1475                1480                1485            
  Pro Gly Arg Gly Leu Asp Ala Gly Ala Lys Gly Val Phe Leu Ser Leu
      1490                1495                1500                
  Gly Lys Gly Phe Ala Ser Leu Met Asp Glu Pro Glu Thr Ser Asn Val
  1505                1510                1515                1520
  Leu Arg His Ile Glu Asn Ala Val Gly Ser Val Arg Asp Asp Val Leu
                  1525                1530                1535    
  Ile Gly Asp Ala Gly Ala Asn Val Leu Asn Gly Leu Ala Gly Asn Asp
              1540                1545                1550        
  Val Leu Ser Gly Gly Ala Gly Asp Asp Val Leu Leu Gly Asp Glu Gly
          1555                1560                1565            
  Ser Asp Leu Leu Ser Gly Asp Ala Gly Asn Asp Asp Leu Phe Gly Gly
      1570                1575                1580                
  Gln Gly Asp Asp Thr Tyr Leu Phe Gly Ala Gly Tyr Gly His Asp Thr
  1585                1590                1595                1600
  Ile Tyr Glu Ser Gly Gly Gly His Asp Thr Ile Arg Ile Asn Ala Gly
                  1605                1610                1615    
  Ala Asp Gln Leu Trp Phe Ala Arg Gln Gly Asn Asp Leu Glu Ile Arg
              1620                1625                1630        
  Ile Leu Gly Thr Asp Asp Ala Leu Thr Val His Asp Trp Tyr Arg Asp
          1635                1640                1645            
  Ala Asp His Arg Val Glu Ala Ile His Ala Ala Asn Gln Ala Ile Asp
      1650                1655                1660                 
  
  Pro Ala Gly Ile Glu Lys Leu Val Glu Ala Met Ala Gln Tyr Pro Asp
  1665                1670                1675                1680
  Pro Gly Ala Ala Ala Ala Ala Pro Pro Ala Ala Arg Val Pro Asp Thr
                  1685                1690                1695    
  Leu Met Gln Ser Leu Ala Val Asn Trp Arg
              1700                1705    
  
  
  <210> 10
  <211> 381
  <212> PRT
  <213> Mus musculus
  
  <400> 10
  Met Pro Phe Ser Asn Ser His Asn Thr Gln Lys Leu Arg Phe Pro Ala
   1               5                  10                  15      
  Glu Asp Glu Phe Pro Asp Leu Ser Ser His Asn Asn His Met Ala Lys
              20                  25                  30          
  Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Cys Thr Pro
          35                  40                  45              
  Ser Gly Phe Thr Leu Asp Asp Ala Ile Gln Thr Gly Val Asp Asn Pro
      50                  55                  60                  
  Gly His Pro Tyr Ile Met Thr Val Gly Ala Val Ala Gly Asp Glu Glu
  65                  70                  75                  80  
  Ser Tyr Asp Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Glu Arg
                  85                  90                  95      
  His Gly Gly Tyr Gln Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro
              100                 105                 110         
  Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser
          115                 120                 125             
  Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro
      130                 135                 140                 
  His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu
  145                 150                 155                 160 
  Ala Leu Ser Ser Leu Asp Gly Asp Leu Ser Gly Arg Tyr Tyr Ala Leu
                  165                 170                 175     
  Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe
              180                 185                 190          
  
  Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala
          195                 200                 205             
  Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr
      210                 215                 220                 
  Phe Leu Val Trp Ile Asn Glu Glu Asp His Leu Arg Val Ile Ser Met
  225                 230                 235                 240 
  Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly
                  245                 250                 255     
  Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asn Tyr Glu Phe Met
              260                 265                 270         
  Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly
          275                 280                 285             
  Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro His Leu Gly Lys
      290                 295                 300                 
  His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg
  305                 310                 315                 320 
  Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val
                  325                 330                 335     
  Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met
              340                 345                 350         
  Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu
          355                 360                 365             
  Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys
      370                 375                 380     
  
  
  <210> 11
  <211> 381
  <212> PRT
  <213> Mus musculus
  
  <400> 11
  Met Pro Phe Gly Asn Thr His Asn Lys Phe Lys Leu Asn Tyr Lys Pro
   1               5                  10                  15      
  Gln Glu Glu Tyr Pro Asp Leu Ser Lys His Asn Asn His Met Ala Lys
              20                  25                  30          
  Val Leu Thr Pro Asp Leu Tyr Asn Lys Leu Arg Asp Lys Glu Thr Pro
          35                  40                  45               
  
  Ser Gly Phe Thr Leu Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro
      50                  55                  60                  
  Gly His Pro Phe Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu
  65                  70                  75                  80  
  Ser Tyr Thr Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Gln Asp Arg
                  85                  90                  95      
  His Gly Gly Tyr Lys Pro Thr Asp Lys His Lys Thr Asp Leu Asn His
              100                 105                 110         
  Glu Asn Leu Lys Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser
          115                 120                 125             
  Ser Arg Val Arg Thr Gly Arg Ser Ile Lys Gly Tyr Thr Leu Pro Pro
      130                 135                 140                 
  His Cys Ser Arg Gly Glu Arg Arg Ala Val Glu Lys Leu Ser Val Glu
  145                 150                 155                 160 
  Ala Leu Asn Ser Leu Thr Gly Glu Phe Lys Gly Lys Tyr Tyr Pro Leu
                  165                 170                 175     
  Lys Ser Met Thr Glu Gln Glu Gln Gln Gln Leu Ile Asp Asp His Phe
              180                 185                 190         
  Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala
          195                 200                 205             
  Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Ser
      210                 215                 220                 
  Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met
  225                 230                 235                 240 
  Glu Lys Gly Gly Asn Met Lys Glu Val Phe Arg Arg Phe Cys Val Gly
                  245                 250                 255     
  Leu Gln Lys Ile Glu Glu Ile Phe Lys Lys Ala Gly His Pro Phe Met
              260                 265                 270         
  Trp Asn Glu His Leu Gly Tyr Val Leu Thr Cys Pro Ser Asn Leu Gly
          275                 280                 285             
  Thr Gly Leu Arg Gly Gly Val His Val Lys Leu Ala Asn Leu Ser Lys
      290                 295                 300                 
  His Pro Lys Phe Glu Glu Ile Leu Thr Arg Leu Arg Leu Gln Lys Arg
  305                 310                 315                 320 
  Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Ala Val Phe Asp Ile
                  325                 330                 335     
  Ser Asn Ala Asp Arg Leu Gly Ser Ser Glu Val Glu Gln Val Gln Leu
              340                 345                 350          
  
  Val Val Asp Gly Val Lys Leu Met Val Glu Met Glu Lys Lys Leu Glu
          355                 360                 365             
  Lys Gly Gln Ser Ile Asp Asp Met Ile Pro Ala Gln Lys
      370                 375                 380     
  
  
  <210> 12
  <211> 381
  <212> PRT
  <213> Homo sapiens
  
  <400> 12
  Met Pro Phe Ser Asn Ser His Asn Ala Leu Lys Leu Arg Phe Pro Ala
   1               5                  10                  15      
  Glu Asp Glu Phe Pro Asp Leu Ser Ala His Asn Asn His Met Ala Lys
              20                  25                  30          
  Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Ser Thr Pro
          35                  40                  45              
  Ser Gly Phe Thr Leu Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro
      50                  55                  60                  
  Gly His Pro Tyr Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu
  65                  70                  75                  80  
  Ser Tyr Glu Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Asp Arg
                  85                  90                  95      
  His Gly Gly Tyr Lys Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro
              100                 105                 110         
  Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser
          115                 120                 125             
  Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro
      130                 135                 140                 
  His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu
  145                 150                 155                 160 
  Ala Leu Ser Ser Leu Asp Gly Asp Leu Ala Gly Arg Tyr Tyr Ala Leu
                  165                 170                 175     
  Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe
              180                 185                 190         
  Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Ser Ala Ser Gly Met Ala
          195                 200                 205              
  
  Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr
      210                 215                 220                 
  Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met
  225                 230                 235                 240 
  Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly
                  245                 250                 255     
  Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asp Tyr Glu Phe Met
              260                 265                 270         
  Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly
          275                 280                 285             
  Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Asn Leu Gly Lys
      290                 295                 300                 
  His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg
  305                 310                 315                 320 
  Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val
                  325                 330                 335     
  Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met
              340                 345                 350         
  Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu
          355                 360                 365             
  Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys
      370                 375                 380     
  
  
  <210> 13
  <211> 446
  <212> PRT
  <213> Thermoproteus tenax
  
  <400> 13
  Met Phe Thr Lys Ile Val Ala Thr Leu Gly Pro Ser Thr Asp Arg Leu
   1               5                  10                  15      
  Pro Asp Ile Thr Ala Leu Leu Ser Lys Val His Gly Val Arg Ile Asn
              20                  25                  30          
  Met Ser His Ala Ser Pro Ser Glu Val Glu Ala Arg Val Asn Ala Val
          35                  40                  45              
  Arg Lys Tyr Glu Glu Thr Ser Gly Arg Tyr Ile Ala Ile Ile Ala Asp
      50                  55                  60                   
  
  Leu Arg Gly Pro Ser Val Arg Thr Gly Leu Met Arg Pro Leu Gln Ile
  65                  70                  75                  80  
  Thr Ala Gly Ala Arg Val Ser Phe Lys Leu Ala Glu Lys Gly Asp Gly
                  85                  90                  95      
  Phe Val Pro Val Pro Arg Arg Glu Phe Phe Glu Val Ile Glu Glu Gly
              100                 105                 110         
  Asp Glu Val Leu Met Leu Asp Gly Lys Leu Val Leu Arg Ile Ile Ser
          115                 120                 125             
  Ala Ala Gln Thr Ser Ala Glu Ala Glu Ser Leu Ser Ser Gly Val Ile
      130                 135                 140                 
  Ser Ser Asn Lys Ala Ile Val Val Lys Gly Lys Glu Tyr His Ile Glu
  145                 150                 155                 160 
  Gln Pro Val Glu Glu Asp Ile Arg Ala Leu Gln Thr Leu Ser Arg Phe
                  165                 170                 175     
  Arg Asp Asp Val Asp Tyr Val Ala Leu Ser Leu Val Arg Asp Gly Ala
              180                 185                 190         
  Asp Val Arg Lys Met Arg Ser Val Val Glu Glu Ala Gly Leu Thr Ser
          195                 200                 205             
  Gly Ile Met Ala Lys Ile Glu Thr Lys Ser Ala Val Asp Lys Ile Glu
      210                 215                 220                 
  Glu Ile Ile Asn Ala Ala Asp Tyr Ile Val Ile Ala Arg Gly Asp Leu
  225                 230                 235                 240 
  Ala Leu His Tyr Gly Leu Glu Tyr Ile Pro Lys Val Gln Arg Leu Leu
                  245                 250                 255     
  Val Glu Arg Ser Leu Ser Ala Gly Arg Pro Val Ala Val Ala Thr Gln
              260                 265                 270         
  Leu Leu Asp Ser Met Gln Thr Asn Thr Thr Pro Thr Arg Ala Glu Val
          275                 280                 285             
  Asn Asp Val Tyr Thr Thr Ala Ser Leu Gly Val Asp Ser Leu Trp Leu
      290                 295                 300                 
  Thr Asn Glu Thr Ala Ser Gly Glu His Pro Leu Glu Ala Val Asp Trp
  305                 310                 315                 320 
  Leu Arg Arg Ile Val Ser Gln Val Glu Phe Gly Arg Leu Lys Ala Ala
                  325                 330                 335     
  Ser Pro Ala Asp Ala Arg Asp Arg Phe Ala Lys Ala Val Val Asp Met
              340                 345                 350         
  Ala Glu Asp Met Gly Gly Glu Ile Ala Val Tyr Ser Met Thr Gly Thr
          355                 360                 365             
  
  Leu Ala Lys Arg Ile Ala Lys Phe Arg Pro Met Thr Thr Val Tyr Val
      370                 375                 380                 
  Gly Val Asn Glu Arg Arg Leu Ala Arg Met Leu Glu Leu Arg Glu Asp
  385                 390                 395                 400 
  Val Gly Ala His Met Gly Pro Arg Ala Cys Gly Arg Ala Gly Ala Tyr
                  405                 410                 415     
  Leu Arg Gly Gly Pro Arg Glu Ala Pro Leu Gln Ile Leu Arg Gln Ser
              420                 425                 430         
  Leu Asp Ser His Val Trp Ala Gln Arg Arg His Thr Tyr Tyr
          435                 440                 445     
  
  
  <210> 14
  <211> 531
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic ADP to ATP converting enzyme.
  
  <400> 14
  Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln
   1               5                  10                  15      
  Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg
              20                  25                  30          
  Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile
          35                  40                  45              
  Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met
      50                  55                  60                  
  Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr
  65                  70                  75                  80  
  His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu
                  85                  90                  95      
  Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu
              100                 105                 110         
  Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly
          115                 120                 125             
  Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu
      130                 135                 140                 
  Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp
  145                 150                 155                 160 
  Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val
                  165                 170                 175     
  Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe
              180                 185                 190         
  Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly
          195                 200                 205             
  Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys
      210                 215                 220                 
  Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val
  225                 230                 235                 240 
  Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys
                  245                 250                 255     
  Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu
              260                 265                 270         
  Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp
          275                 280                 285             
  Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu
      290                 295                 300                 
  Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala
  305                 310                 315                 320 
  Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys
                  325                 330                 335     
  Lys Pro Pro Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val
              340                 345                 350         
  Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly
          355                 360                 365             
  Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu
      370                 375                 380                 
  Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg
  385                 390                 395                 400 
  Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala
                  405                 410                 415     
  Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr
              420                 425                 430         
  Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala
          435                 440                 445             
  
  Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His
      450                 455                 460                 
  Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu
  465                 470                 475                 480 
  Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val
                  485                 490                 495     
  Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu
              500                 505                 510         
  Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val
          515                 520                 525             
  Pro Val Pro
      530     
  
  
  <210> 15
  <211> 194
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> A synthetic ADP to ATP converting enzyme.
  
  <400> 15
  Met Glu Glu Lys Leu Lys Lys Thr Lys Ile Ile Phe Val Val Gly Gly
   1               5                  10                  15      
  Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu Lys Ile Val Gln Lys Tyr
              20                  25                  30          
  Gly Tyr Thr His Leu Ser Thr Gly Asp Leu Leu Arg Ser Glu Val Ser
          35                  40                  45              
  Ser Gly Ser Ala Arg Gly Lys Lys Leu Ser Glu Ile Met Glu Lys Gly
      50                  55                  60                  
  Gln Leu Val Pro Leu Glu Thr Val Leu Asp Met Leu Arg Asp Ala Met
  65                  70                  75                  80  
  Val Ala Lys Val Asn Thr Ser Lys Gly Phe Leu Ile Asp Gly Tyr Pro
                  85                  90                  95      
  Arg Glu Val Gln Gln Gly Glu Glu Phe Glu Arg Arg Ile Gly Gln Pro
              100                 105                 110         
  Thr Leu Leu Leu Tyr Val Asp Ala Gly Pro Glu Thr Met Thr Gln Arg
          115                 120                 125             
  Leu Leu Lys Arg Gly Glu Thr Ser Gly Arg Val Asp Asp Asn Glu Glu
      130                 135                 140                 
  Thr Ile Lys Lys Arg Leu Glu Thr Tyr Tyr Lys Ala Thr Glu Pro Val
  145                 150                 155                 160 
  Ile Ala Phe Tyr Glu Lys Arg Gly Ile Val Arg Lys Val Asn Ala Glu
                  165                 170                 175     
  Gly Ser Val Asp Ser Val Phe Ser Gln Val Cys Thr His Leu Asp Ala
              180                 185                 190         
  Leu Lys
          
  
