                         SEQUENCE LISTING

<110>  Xenon Pharmaceuticals Inc.
 
<120>  METHODS FOR THE TREATMENT, PREVENTION AND DIAGNOSIS OF LIPID 
       METABOLISM ASSOCIATED DISEASES

<130>  760/13180.55

<150>  61/083,401
<151>  2008-07-24

<160>  217   

<170>  PatentIn version 3.5

<210>  1
<211>  1001
<212>  DNA
<213>  Mus musculus

<400>  1
agggccaggc tgagcttatc agtctcccag cccagcccct gcccacacac atatatagac       60

cagggaagaa gagctggaca cccagactgt cggagagctc cggggaggtc acccacaccc      120

ttcaggatga aagctgtggt gctggccgtg gctctggtct tcctgacagg gagccaggct      180

tggcacgtat ggcagcaaga tgaaccccag tcccaatggg acaaagtgaa ggatttcgct      240

aatgtgtatg tggatgcggt caaagacagc ggcagagact atgtgtccca gtttgaatcc      300

tcctccttgg gccaacagct gaacctgaat ctcctggaaa actgggacac tctgggttca      360

accgttagtc agctgcagga acggctgggc ccattgactc gggacttctg ggataacctg      420

gagaaagaaa cagattgggt gagacaggag atgaacaagg acctagagga agtgaaacag      480

aaggtgcagc cctacctgga cgaattccag aagaaatgga aagaggatgt ggagctctac      540

cgccagaagg tggcgcctct gggcgccgag ctgcaggaga gcgcgcgcca gaagctgcag      600

gagctgcaag ggagactgtc ccctgtggct gaggaatttc gcgaccgcat gcgcacacac      660

gtagactctc tgcgcacaca gctagcgccc cacagcgaac agatgcgcga gagcctggcc      720

cagcgcctgg ctgagctcaa gagcaaccct accttgaacg agtaccacac cagggccaaa      780

acccacctga agacacttgg cgagaaagcc agacctgcgc tggaggacct gcgccatagt      840

ctgatgccca tgctggagac gcttaagacc caagtccaga gtgtgatcga caaggccagc      900

gagactctga ctgcccagtg aggtgcccgc ttccactccc cacccccgca ttggctttct      960

tacaataaac ctttccaaaa tggaaaaaaa aaaaaaaaaa a                         1001


<210>  2
<211>  264
<212>  PRT
<213>  Mus musculus

<400>  2

Met Lys Ala Val Val Leu Ala Val Ala Leu Val Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Trp His Val Trp Gln Gln Asp Glu Pro Gln Ser Gln Trp Asp 
            20                  25                  30          


Lys Val Lys Asp Phe Ala Asn Val Tyr Val Asp Ala Val Lys Asp Ser 
        35                  40                  45              


Gly Arg Asp Tyr Val Ser Gln Phe Glu Ser Ser Ser Leu Gly Gln Gln 
    50                  55                  60                  


Leu Asn Leu Asn Leu Leu Glu Asn Trp Asp Thr Leu Gly Ser Thr Val 
65                  70                  75                  80  


Ser Gln Leu Gln Glu Arg Leu Gly Pro Leu Thr Arg Asp Phe Trp Asp 
                85                  90                  95      


Asn Leu Glu Lys Glu Thr Asp Trp Val Arg Gln Glu Met Asn Lys Asp 
            100                 105                 110         


Leu Glu Glu Val Lys Gln Lys Val Gln Pro Tyr Leu Asp Glu Phe Gln 
        115                 120                 125             


Lys Lys Trp Lys Glu Asp Val Glu Leu Tyr Arg Gln Lys Val Ala Pro 
    130                 135                 140                 


Leu Gly Ala Glu Leu Gln Glu Ser Ala Arg Gln Lys Leu Gln Glu Leu 
145                 150                 155                 160 


Gln Gly Arg Leu Ser Pro Val Ala Glu Glu Phe Arg Asp Arg Met Arg 
                165                 170                 175     


Thr His Val Asp Ser Leu Arg Thr Gln Leu Ala Pro His Ser Glu Gln 
            180                 185                 190         


Met Arg Glu Ser Leu Ala Gln Arg Leu Ala Glu Leu Lys Ser Asn Pro 
        195                 200                 205             


Thr Leu Asn Glu Tyr His Thr Arg Ala Lys Thr His Leu Lys Thr Leu 
    210                 215                 220                 


Gly Glu Lys Ala Arg Pro Ala Leu Glu Asp Leu Arg His Ser Leu Met 
225                 230                 235                 240 


Pro Met Leu Glu Thr Leu Lys Thr Gln Val Gln Ser Val Ile Asp Lys 
                245                 250                 255     


Ala Ser Glu Thr Leu Thr Ala Gln 
            260                 


<210>  3
<211>  1001
<212>  DNA
<213>  Mus Musculus

<400>  3
agggccaggc tgagcttatc agtctcccag cccagcccct gcccacacac atatatagac       60

cagggaagaa gagctggaca cccagactgt cggagagctc cggggaggtc acccacaccc      120

ttcaggatga aagctgtggt gctggccgtg gctctggtct tcctgacagg gagccaggct      180

tggcacgtat gttagcaaga tgaaccccag tcccaatggg acaaagtgaa ggatttcgct      240

aatgtgtatg tggatgcggt caaagacagc ggcagagact atgtgtccca gtttgaatcc      300

tcctccttgg gccaacagct gaacctgaat ctcctggaaa actgggacac tctgggttca      360

accgttagtc agctgcagga acggctgggc ccattgactc gggacttctg ggataacctg      420

gagaaagaaa cagattgggt gagacaggag atgaacaagg acctagagga agtgaaacag      480

aaggtgcagc cctacctgga cgaattccag aagaaatgga aagaggatgt ggagctctac      540

cgccagaagg tggcgcctct gggcgccgag ctgcaggaga gcgcgcgcca gaagctgcag      600

gagctgcaag ggagactgtc ccctgtggct gaggaatttc gcgaccgcat gcgcacacac      660

gtagactctc tgcgcacaca gctagcgccc cacagcgaac agatgcgcga gagcctggcc      720

cagcgcctgg ctgagctcaa gagcaaccct accttgaacg agtaccacac cagggccaaa      780

acccacctga agacacttgg cgagaaagcc agacctgcgc tggaggacct gcgccatagt      840

ctgatgccca tgctggagac gcttaagacc caagtccaga gtgtgatcga caaggccagc      900

gagactctga ctgcccagtg aggtgcccgc ttccactccc cacccccgca ttggctttct      960

tacaataaac ctttccaaaa tggaaaaaaa aaaaaaaaaa a                         1001


<210>  4
<211>  22
<212>  PRT
<213>  Mus Musculus

<400>  4

Met Lys Ala Val Val Leu Ala Val Ala Leu Val Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Trp His Val Cys 
            20          


<210>  5
<211>  897
<212>  DNA
<213>  Homo sapiens

<400>  5
agagactgcg agaaggaggt cccccacggc ccttcaggat gaaagctgcg gtgctgacct       60

tggccgtgct cttcctgacg gggagccagg ctcggcattt ctggcagcaa gatgaacccc      120

cccagagccc ctgggatcga gtgaaggacc tggccactgt gtacgtggat gtgctcaaag      180

acagcggcag agactatgtg tcccagtttg aaggctccgc cttgggaaaa cagctaaacc      240

taaagctcct tgacaactgg gacagcgtga cctccacctt cagcaagctg cgcgaacagc      300

tcggccctgt gacccaggag ttctgggata acctggaaaa ggagacagag ggcctgaggc      360

aggagatgag caaggatctg gaggaggtga aggccaaggt gcagccctac ctggacgact      420

tccagaagaa gtggcaggag gagatggagc tctaccgcca gaaggtggag ccgctgcgcg      480

cagagctcca agagggcgcg cgccagaagc tgcacgagct gcaagagaag ctgagcccac      540

tgggcgagga gatgcgcgac cgcgcgcgcg cccatgtgga cgcgctgcgc acgcatctgg      600

ccccctacag cgacgagctg cgccagcgct tggccgcgcg ccttgaggct ctcaaggaga      660

acggcggcgc cagactggcc gagtaccacg ccaaggccac cgagcatctg agcacgctca      720

gcgagaaggc caagcccgcg ctcgaggacc tccgccaagg cctgctgccc gtgctggaga      780

gcttcaaggt cagcttcctg agcgctctcg aggagtacac taagaagctc aacacccagt      840

gaggcgcccg ccgccgcccc ccttcccggt gctcagaata aacgtttcca aagtggg         897


<210>  6
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  7
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  7
cgccgccgcg cacatgccta ggttcgacgc cctcctccct ttgcccagga gttccttctg       60

tcccggctct gttccgtctc gccccgaggt tcacgccatc ctcggagccc cagcctttca      120

cccagcgcct ccaagctttg gaccttgact tctgcaaaac tagatggtca cagccatgaa      180

tgtctcacat gaagtaaatc agctgttcca gccctataac ttcgagctgt ccaaggacat      240

gaggcccttt ttcgaggagt attgggcaac ctcattcccc atagccctga tctacctggt      300

tctcatcgct gtggggcaga actacatgaa ggaacgcaag ggcttcaacc tgcaagggcc      360

tctcatcctc tggtccttct gccttgcaat cttcagtatc ctgggggcag tgaggatgtg      420

gggcattatg gggactgtgc tacttaccgg gggcctaaag caaaccgtgt gcttcatcaa      480

cttcatcgat aattccacag tcaaattctg gtcctgggtc tttcttctca gcaaggtcat      540

agaactcgga gacacagcct tcatcatcct gcgtaagcgg ccactcatct ttattcactg      600

gtaccaccac agcacagtgc tcgtgtacac aagctttgga tacaagaaca aagtgcctgc      660

aggaggctgg ttcgtcacca tgaactttgg tgttcatgcc atcatgtaca cctactacac      720

tctgaaggct gccaacgtga agccccccaa gatgctgccc atgctcatca ccagcctgca      780

gatcttgcag atgtttgtag gagccatcgt cagcatcctc acgtacatct ggaggcagga      840

tcagggatgc cacaccacga tggaacactt attctggtcc ttcatcttgt atatgaccta      900

tttcatcctc tttgcccact tcttctgcca gacctacatc aggcccaagg tcaaagccaa      960

gaccaagagc cagtgaaggt ttggagagaa caatgaagct ccaggctctc tcttctccag     1020

ggcaccaaga ggctgggctt agttttggga gaatgattag gttgccttac ctgcatggtt     1080

tccccagagg atgtgtgccc caaggtggct ggaatttttg acagacaaga agggtgacct     1140

tgggatgggg gtgtggtctg ttactttaat gtttctgttt ttaatgtgaa ggccaagcag     1200

gccctgggat gggagtgggg cggaggaggg tcctaagagc tgattattta atttctatcc     1260

agaaatcttt cttcttcttg ctctgttttt ttaaattaaa gatttcaaca aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaa                                         1347


<210>  8
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Thr Ala Met Asn Val Ser His Glu Val Asn Gln Leu Phe Gln 
1               5                   10                  15      


Pro Tyr Asn Phe Glu Leu Ser Lys Asp Met Arg Pro Phe Phe Glu Glu 
            20                  25                  30          


Tyr Trp Ala Thr Ser Phe Pro Ile Ala Leu Ile Tyr Leu Val Leu Ile 
        35                  40                  45              


Ala Val Gly Gln Asn Tyr Met Lys Glu Arg Lys Gly Phe Asn Leu Gln 
    50                  55                  60                  


Gly Pro Leu Ile Leu Trp Ser Phe Cys Leu Ala Ile Phe Ser Ile Leu 
65                  70                  75                  80  


Gly Ala Val Arg Met Trp Gly Ile Met Gly Thr Val Leu Leu Thr Gly 
                85                  90                  95      


Gly Leu Lys Gln Thr Val Cys Phe Ile Asn Phe Ile Asp Asn Ser Thr 
            100                 105                 110         


Val Lys Phe Trp Ser Trp Val Phe Leu Leu Ser Lys Val Ile Glu Leu 
        115                 120                 125             


Gly Asp Thr Ala Phe Ile Ile Leu Arg Lys Arg Pro Leu Ile Phe Ile 
    130                 135                 140                 


His Trp Tyr His His Ser Thr Val Leu Val Tyr Thr Ser Phe Gly Tyr 
145                 150                 155                 160 


Lys Asn Lys Val Pro Ala Gly Gly Trp Phe Val Thr Met Asn Phe Gly 
                165                 170                 175     


Val His Ala Ile Met Tyr Thr Tyr Tyr Thr Leu Lys Ala Ala Asn Val 
            180                 185                 190         


Lys Pro Pro Lys Met Leu Pro Met Leu Ile Thr Ser Leu Gln Ile Leu 
        195                 200                 205             


Gln Met Phe Val Gly Ala Ile Val Ser Ile Leu Thr Tyr Ile Trp Arg 
    210                 215                 220                 


Gln Asp Gln Gly Cys His Thr Thr Met Glu His Leu Phe Trp Ser Phe 
225                 230                 235                 240 


Ile Leu Tyr Met Thr Tyr Phe Ile Leu Phe Ala His Phe Phe Cys Gln 
                245                 250                 255     


Thr Tyr Ile Arg Pro Lys Val Lys Ala Lys Thr Lys Ser Gln 
            260                 265                 270 


<210>  9
<211>  4231
<212>  DNA
<213>  Homo sapiens

<400>  9
atatgtagcc ttttcatttt catgaaagtg aagtgatttt tagaattctt agttgttttc       60

tttagaagaa catttctagg gaataataca agaagattta ggaatcattg aagttataaa      120

tctttggaat gagcaaactc agaatggtgc tacttgaaga ctctggatct gctgacttca      180

gaagacattt tgtcaacttg agtcccttca ccattactgt ggtcttactt ctcagtgcct      240

gttttgtcac cagttctctt ggaggaacag acaaggagct gaggctagtg gatggtgaaa      300

acaagtgtag cgggagagtg gaagtgaaag tccaggagga gtggggaacg gtgtgtaata      360

atggctggag catggaagcg gtctctgtga tttgtaacca gctgggatgt ccaactgcta      420

tcaaagcccc tggatgggct aattccagtg caggttctgg acgcatttgg atggatcatg      480

tttcttgtcg tgggaatgag tcagctcttt gggattgcaa acatgatgga tggggaaagc      540

atagtaactg tactcaccaa caagatgctg gagtgacctg ctcagatgga tccaatttgg      600

aaatgaggct gacgcgtgga gggaatatgt gttctggaag aatagagatc aaattccaag      660

gacggtgggg aacagtgtgt gatgataact tcaacataga tcatgcatct gtcatttgta      720

gacaacttga atgtggaagt gctgtcagtt tctctggttc atctaatttt ggagaaggct      780

ctggaccaat ctggtttgat gatcttatat gcaacggaaa tgagtcagct ctctggaact      840

gcaaacatca aggatgggga aagcataact gtgatcatgc tgaggatgct ggagtgattt      900

gctcaaaggg agcagatctg agcctgagac tggtagatgg agtcactgaa tgttcaggaa      960

gattagaagt gagattccaa ggagaatggg ggacaatatg tgatgacggc tgggacagtt     1020

acgatgctgc tgtggcatgc aagcaactgg gatgtccaac tgccgtcaca gccattggtc     1080

gagttaacgc cagtaaggga tttggacaca tctggcttga cagcgtttct tgccagggac     1140

atgaacctgc tgtctggcaa tgtaaacacc atgaatgggg aaagcattat tgcaatcaca     1200

atgaagatgc tggcgtgaca tgttctgatg gatcagatct ggagctaaga cttagaggtg     1260

gaggcagccg ctgtgctggg acagttgagg tggagattca gagactgtta gggaaggtgt     1320

gtgacagagg ctggggactg aaagaagctg atgtggtttg caggcagctg ggatgtggat     1380

ctgcactcaa aacatcttat caagtgtact ccaaaatcca ggcaacaaac acatggctgt     1440

ttctaagtag ctgtaacgga aatgaaactt ctctttggga ctgcaagaac tggcaatggg     1500

gtggacttac ctgtgatcac tatgaagaag ccaaaattac ctgctcagcc cacagggaac     1560

ccagactggt tggaggggac attccctgtt ctggacgtgt tgaagtgaag catggtgaca     1620

cgtggggctc catctgtgat tcggacttct ctctggaagc tgccagcgtt ctatgcaggg     1680

aattacagtg tggcacagtt gtctctatcc tggggggagc tcactttgga gagggaaatg     1740

gacagatctg ggctgaagaa ttccagtgtg agggacatga gtcccatctt tcactctgcc     1800

cagtagcacc ccgcccagaa ggaacttgta gccacagcag ggatgttgga gtagtctgct     1860

caagatacac agaaattcgc ttggtgaatg gcaagacccc gtgtgagggc agagtggagc     1920

tcaaaacgct tggtgcctgg ggatccctct gtaactctca ctgggacata gaagatgccc     1980

atgttctttg ccagcagctt aaatgtggag ttgccctttc taccccagga ggagcacgtt     2040

ttggaaaagg aaatggtcag atctggaggc atatgtttca ctgcactggg actgagcagc     2100

acatgggaga ttgtcctgta actgctctag gtgcttcatt atgtccttca gagcaagtgg     2160

cctctgtaat ctgctcagga aaccagtccc aaacactgtc ctcgtgcaat tcatcgtctt     2220

tgggcccaac aaggcctacc attccagaag aaagtgctgt ggcctgcata gagagtggtc     2280

aacttcgcct ggtaaatgga ggaggtcgct gtgctgggag agtagagatc tatcatgagg     2340

gctcctgggg caccatctgt gatgacagct gggacctgag tgatgcccac gtggtttgca     2400

gacagctggg ctgtggagag gccattaatg ccactggttc tgctcatttt ggggaaggaa     2460

cagggcccat ctggctggat gagatgaaat gcaatggaaa agaatcccgc atttggcagt     2520

gccattcaca cggctggggg cagcaaaatt gcaggcacaa ggaggatgcg ggagttatct     2580

gctcagaatt catgtctctg agactgacca gtgaagccag cagagaggcc tgtgcagggc     2640

gtctggaagt tttttacaat ggagcttggg gcactgttgg caagagtagc atgtctgaaa     2700

ccactgtggg tgtggtgtgc aggcagctgg gctgtgcaga caaagggaaa atcaaccctg     2760

catctttaga caaggccatg tccattccca tgtgggtgga caatgttcag tgtccaaaag     2820

gacctgacac gctgtggcag tgcccatcat ctccatggga gaagagactg gccagcccct     2880

cggaggagac ctggatcaca tgtgacaaca agataagact tcaggaagga cccacttcct     2940

gttctggacg tgtggagatc tggcatggag gttcctgggg gacagtgtgt gatgactctt     3000

gggacttgga cgatgctcag gtggtgtgtc aacaacttgg ctgtggtcca gctttgaaag     3060

cattcaaaga agcagagttt ggtcagggga ctggaccgat atggctcaat gaagtgaagt     3120

gcaaagggaa tgagtcttcc ttgtgggatt gtcctgccag acgctggggc catagtgagt     3180

gtgggcacaa ggaagacgct gcagtgaatt gcacagatat ttcagtgcag aaaaccccac     3240

aaaaagccac aacaggtcgc tcatcccgtc agtcatcctt tattgcagtc gggatccttg     3300

gggttgttct gttggccatt ttcgtcgcat tattcttctt gactaaaaag cgaagacaga     3360

gacagcggct tgcagtttcc tcaagaggag agaacttagt ccaccaaatt caataccggg     3420

agatgaattc ttgcctgaat gcagatgatc tggacctaat gaattcctca gaaaattccc     3480

atgagtcagc tgatttcagt gctgctgaac taatttctgt gtctaaattt cttcctattt     3540

ctggaatgga aaaggaggcc attctgagcc acactgaaaa ggaaaatggg aatttataac     3600

ccagtgagtt cagcctttaa gataccttga tgaagacctg gactattgaa tggagcagaa     3660

attcacctct ctcactgact attacagttg catttttatg gagttcttct tctcctagga     3720

ttcctaagac tgctgctgaa tttataaaaa ttaagtttgt gaatgtgact acttagtggt     3780

gtatatgaga ctttcaaggg aattaaataa ataaataaga atgttattga tttgagtttg     3840

ctttaattac ttgtccttaa ttctattaat ttctaaatgg gcttcctaat tttttgtaga     3900

gtttcctaga tgtattataa tgtgttttat ttgacagtgt ttcaatttgc atatacagta     3960

ctgtatattt tttcttattt ggtttgaata attttcctat taccaaataa aaataaattt     4020

atttttactt tagtttttct aagacaggaa aagttaatga tattgaaggg tctgtaaata     4080

atatatggct aactttataa ggcatgactc acaacgattc tttaactgct ttttgttact     4140

gtaattctgt tcactagaat aaaatgcaga gccacacctg gtgagggcac aaaaaaaaaa     4200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    4231


<210>  10
<211>  1156
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Val Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210>  11
<211>  2077
<212>  DNA
<213>  Homo sapiens

<400>  11
ccgagcgcca gcgcggggaa ccgggaaaag gaaaccgtgt tgtgtacgta agattcagga       60

aacgaaacca ggagccgcgg gtgttggcgc aaaggttact cccagaccct tttccggctg      120

acttctgaga aggttgcgca cagctgtgcc cggcagtcta gaggcgcaga agaggaagcc      180

atcgcctggc cccggctctc tggaccttgt ctcgctcggg agcggaaaca gcggcagcca      240

gagaactgtt ttaatcatgg acaaacaaaa ctcacagatg aatgcttctc acccggaaac      300

aaacttgcca gttgggtatc ctcctcagta tccaccgaca gcattccaag gacctccagg      360

atatagtggc taccctgggc cccaggtcag ctacccaccc ccaccagccg gccattcagg      420

tcctggccca gctggctttc ctgtcccaaa tcagccagtg tataatcagc cagtatataa      480

tcagccagtt ggagctgcag gggtaccatg gatgccagcg ccacagcctc cattaaactg      540

tccacctgga ttagaatatt taagtcagat agatcagata ctgattcatc agcaaattga      600

acttctggaa gttttaacag gttttgaaac taataacaaa tatgaaatta agaacagctt      660

tggacagagg gtttactttg cagcggaaga tactgattgc tgtacccgaa attgctgtgg      720

gccatctaga ccttttacct tgaggattat tgataatatg ggtcaagaag tcataactct      780

ggagagacca ctaagatgta gcagctgttg ttgtccctgc tgccttcagg agatagaaat      840

ccaagctcct cctggtgtac caataggtta tgttattcag acttggcacc catgtctacc      900

aaagtttaca attcaaaatg agaaaagaga ggatgtacta aaaataagtg gtccatgtgt      960

tgtgtgcagc tgttgtggag atgttgattt tgagattaaa tctcttgatg aacagtgtgt     1020

ggttggcaaa atttccaagc actggactgg aattttgaga gaggcattta cagacgctga     1080

taactttgga atccagttcc ctttagacct tgatgttaaa atgaaagctg taatgattgg     1140

tgcctgtttc ctcattgact tcatgttttt tgaaagcact ggcagccagg aacaaaaatc     1200

aggagtgtgg tagtggatta gtgaaagtct cctcaggaaa tctgaagtct gtatattgat     1260

tgagactatc taaactcata cctgtatgaa ttaagctgta aggcctgtag ctctggttgt     1320

atacttttgc ttttcaaatt atagtttatc ttctgtataa ctgatttata aaggtttttg     1380

tacatttttt aatactcatt gtcaatttga gaaaaaggac atatgagttt ttgcatttat     1440

taatgaaact tcctttgaaa aactgctttg aattatgatc tctgattcat tgtccatttt     1500

actaccaaat attaactaag gccttattaa tttttatata aattatatct tgtcctatta     1560

aatctagtta caatttattt catgcataag agctaatgtt attttgcaaa tgccatatat     1620

tcaaaaaagc tcaaagataa ttttctttac tattatgttc aaataatatt caatatgcat     1680

attatcttta aaaagttaaa tgttttttta atcttcaaga aatcatgcta cacttaactt     1740

ctcctagaag ctaatctata ccataatatt ttcatattca caagatatta aattaccaat     1800

tttcaaatta ttgttagtaa agaacaaaat gattctctcc caaagaaaga cacattttaa     1860

atactccttc actctaaaac tctggtatta taacttttga aagttaatat ttctacatga     1920

aatgtttagc tcttacactc tatccttcct agaaaatggt aattgagatt actcagatat     1980

taattaaata caatatcata tatatattca cagagtataa acctaaataa tgatctatta     2040

gattcaaata tttgaaataa aaacttgatt tttttgt                              2077


<210>  12
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Lys Gln Asn Ser Gln Met Asn Ala Ser His Pro Glu Thr Asn 
1               5                   10                  15      


Leu Pro Val Gly Tyr Pro Pro Gln Tyr Pro Pro Thr Ala Phe Gln Gly 
            20                  25                  30          


Pro Pro Gly Tyr Ser Gly Tyr Pro Gly Pro Gln Val Ser Tyr Pro Pro 
        35                  40                  45              


Pro Pro Ala Gly His Ser Gly Pro Gly Pro Ala Gly Phe Pro Val Pro 
    50                  55                  60                  


Asn Gln Pro Val Tyr Asn Gln Pro Val Tyr Asn Gln Pro Val Gly Ala 
65                  70                  75                  80  


Ala Gly Val Pro Trp Met Pro Ala Pro Gln Pro Pro Leu Asn Cys Pro 
                85                  90                  95      


Pro Gly Leu Glu Tyr Leu Ser Gln Ile Asp Gln Ile Leu Ile His Gln 
            100                 105                 110         


Gln Ile Glu Leu Leu Glu Val Leu Thr Gly Phe Glu Thr Asn Asn Lys 
        115                 120                 125             


Tyr Glu Ile Lys Asn Ser Phe Gly Gln Arg Val Tyr Phe Ala Ala Glu 
    130                 135                 140                 


Asp Thr Asp Cys Cys Thr Arg Asn Cys Cys Gly Pro Ser Arg Pro Phe 
145                 150                 155                 160 


Thr Leu Arg Ile Ile Asp Asn Met Gly Gln Glu Val Ile Thr Leu Glu 
                165                 170                 175     


Arg Pro Leu Arg Cys Ser Ser Cys Cys Cys Pro Cys Cys Leu Gln Glu 
            180                 185                 190         


Ile Glu Ile Gln Ala Pro Pro Gly Val Pro Ile Gly Tyr Val Ile Gln 
        195                 200                 205             


Thr Trp His Pro Cys Leu Pro Lys Phe Thr Ile Gln Asn Glu Lys Arg 
    210                 215                 220                 


Glu Asp Val Leu Lys Ile Ser Gly Pro Cys Val Val Cys Ser Cys Cys 
225                 230                 235                 240 


Gly Asp Val Asp Phe Glu Ile Lys Ser Leu Asp Glu Gln Cys Val Val 
                245                 250                 255     


Gly Lys Ile Ser Lys His Trp Thr Gly Ile Leu Arg Glu Ala Phe Thr 
            260                 265                 270         


Asp Ala Asp Asn Phe Gly Ile Gln Phe Pro Leu Asp Leu Asp Val Lys 
        275                 280                 285             


Met Lys Ala Val Met Ile Gly Ala Cys Phe Leu Ile Asp Phe Met Phe 
    290                 295                 300                 


Phe Glu Ser Thr Gly Ser Gln Glu Gln Lys Ser Gly Val Trp 
305                 310                 315             


<210>  13
<211>  4454
<212>  DNA
<213>  Homo sapiens

<400>  13
agcgctgagc tgcaggcgcg gcgaaacttc cctctacccg cccggcccgc ggcgcgcacc       60

gttggcgctg gacgcttcct ccttggaagc gcctctccct cagttatgga gaaaacttgt      120

atagatgcac ttcctcttac tatgaattct tcagaaaagc aagagactgt atgtattttt      180

ggaactggtg attttggaag atcactggga ttgaaaatgc tccagtgtgg ttattctgtt      240

gtttttggaa gtcgaaaccc ccagaagacc accctactgc ccagtggtgc agaagtcttg      300

agctattcag aagcagccaa gaagtctggc atcataatca tagcaatcca cagagagcat      360

tatgattttc tcacagaatt aactgaggtt ctcaatggaa aaatattggt agacatcagc      420

aacaacctca aaatcaatca atatccagaa tctaatgcag agtaccttgc tcatttggtg      480

ccaggagccc acgtggtaaa agcatttaac accatctcag cctgggctct ccagtcagga      540

gcactggatg caagtcggca ggtgtttgtg tgtggaaatg acagcaaagc caagcaaaga      600

gtgatggata ttgttcgtaa tcttggactt actccaatgg atcaaggatc actcatggca      660

gccaaagaaa ttgaaaagta ccccctgcag ctatttccaa tgtggaggtt ccccttctat      720

ttgtctgctg tgctgtgtgt cttcttgttt ttctattgtg ttataagaga cgtaatctac      780

ccttatgttt atgaaaagaa agataataca tttcgtatgg ctatttccat tccaaatcgt      840

atctttccaa taacagcact tacactgctt gctttggttt acctccctgg tgttattgct      900

gccattctac aactgtaccg aggcacaaaa taccgtcgat tcccagactg gcttgaccac      960

tggatgcttt gccgaaagca gcttggcttg gtagctctgg gatttgcctt ccttcatgtc     1020

ctctacacac ttgtgattcc tattcgatat tatgtacgat ggagattggg aaacttaacc     1080

gttacccagg caatactcaa gaaggagaat ccatttagca cctcctcagc ctggctcagt     1140

gattcatatg tggctttggg aatacttggg ttttttctgt ttgtactctt gggaatcact     1200

tctttgccat ctgttagcaa tgcagtcaac tggagagagt tccgatttgt ccagtccaaa     1260

ctgggttatt tgaccctgat cttgtgtaca gcccacaccc tggtgtacgg tgggaagaga     1320

ttcctcagcc cttcaaatct cagatggtat cttcctgcag cctacgtgtt agggcttatc     1380

attccttgca ctgtgctggt gatcaagttt gtcctaatca tgccatgtgt agacaacacc     1440

cttacaagga tccgccaggg ctgggaaagg aactcaaaac actagaaaaa gcattgaatg     1500

gaaaatcaat atttaaaaca aagttcaatt tagctggatt tctgaactat ggttttgaat     1560

gtttaaagaa gaatgatggg tacagttagg aaagtttttt tcttacaccg tgactgaggg     1620

aaacattgct tgtctttgag aaattgactg acatactgga agagaacacc attttatctc     1680

aggttagtga agaatcagtg caggtccctg actcttattt tcccagaggc catggagctg     1740

agattgagac tagccttgtg gtttcacact aaagagtttc cttgttatgg gcaacatgca     1800

tgacctaatg tcttgcaaaa tccaatagaa gtattgcagc ttccttctct ggctcaaggg     1860

ctgagttaag tgaaaggaaa aacagcacaa tggtgaccac tgataaaggc tttattaggt     1920

atatctgagg aagtgggtca catgaaatgt aaaaagggaa tgaggttttt gttgtttttt     1980

ggaagtaaag gcaaacataa atattaccat gatgaattct agtgaaatga ccccttgact     2040

ttgcttttct taatacagat atttactgag aggaactatt tttataacac aagaaaaatt     2100

tacaattgat taaaagtatc catgtcttgg atacatacgt atctatagag ctggcatgta     2160

attcttcctc tataaagaat aggtatagga aagactgaat aaaaatggag ggatatcccc     2220

ttggatttca cttgcattgt gcaataagca aagaagggtt gataaaagtt cttgatcaaa     2280

aagttcaaag aaaccagaat tttagacagc aagctaaata aatattgtaa aattgcacta     2340

tattaggtta agtattattt aggtattata atatgctttg taaattttat attccaaata     2400

ttgctcaata tttttcatct attaaattaa tttctagtgt aaataagtag cttctatatc     2460

tgtcttagtc tattataatt gtaaggagta aaattaaatg aatagtctgc aggtataaat     2520

ttgaacaatg catagatgat cgaaaattac ggaaaatcat agggcagaga ggtgtgaaga     2580

ttcatcatta tgtgaaattt ggatctttct caaatccttg ctgaaattta ggatggttct     2640

cactgttttt ctgtgctgat agtacccttt ccaaggtgac cttcaggggg attaaccttc     2700

ctagctcaag caatgagcta aaaggagcct tatgcatgat cttcccacat atcaaaataa     2760

ctaaaaggca ctgagtttgg catttttctg cctgctctgc taagaccttt tttttttttt     2820

actttcatta taacatatta tacatgacat tatacaaaaa tgattaaaat atattaaaac     2880

aacatcaaca atccaggata tttttctata aaacttttta aaaataattg tatctatata     2940

ttcaatttta catccttttt caaaggcttt gtttttctaa aggctttgtt ttccttttta     3000

ttattttttt cttttttatt tttttgagac agtcttgctc tgtcgctcag gctggagtgc     3060

agtggcacga tctcagctca ctgcaacctc ctcctcccag gttcaagtga ttcttgttca     3120

tcagcctccc gagtagctgg gactacaggc atgtgccact atgcccagct aatttttgta     3180

cttttagtag agacagggtt tcaccacatt ggtcaggctg gtcttgaaat gctggcgtca     3240

agtgatctgc ctgcctccgc ctcacaaagc actgggatta caggcatgaa tctggcctta     3300

cgtaatatat tttcttaatg gctgcataat atcacatcaa ataggcattt ttcaaacctc     3360

tttccttatt aaacatgtag actatatcca ttttttacta aaataaataa catttcagat     3420

aatatctttg cactgataat gttgccaagc catttctaaa gtgaccttat caatttaatt     3480

accattggat gagggtgttg ctttcatcgc accattgtag attgtctttt ttatttcaat     3540

ttgcgtttat ttataactgg ttgcaaaggt acacagaaca cacgctcctt caacttatct     3600

ttgataaacc caagcaagga tacaaaaagt tggacgacat tgagtagagt catggtatac     3660

ggtgctgacc ctacagtatc agtggaaaag ataaggaaaa tgtcactact cacctatgtt     3720

atgcaaaaca gttaggtgtg ctggggctgg atactgctct tttacttgag cattggttga     3780

ttaaagttta ggtaccatcc aggctggtct agagaagtct ttggagttaa ccatgctctt     3840

tttgttaaag aagagagtaa tgtgtttatc ctggctcata gtccgtcacc gaaaatagaa     3900

aatgccatcc ataggtaaaa tgctgaccta tagaaaaaaa tgaactctac ttttatagcc     3960

tagtaaaaat gctctacctg agtagttaaa agcaattcat gaagcctgaa gctaaagagc     4020

actctgatgg ttttggcata atagctgcat ttccagacct gacctttggc cccaaccaca     4080

agtgctccaa gccccaccag ctgaccaaag aaagcccaag ttctccttct gtccttccca     4140

caacctccct gctcccaaaa ctatgaaatt aatttgacca tattaacaca gctgactcct     4200

ccagtttact taaggtagaa agaatgagtt tacaacagat gaaaataagt gctttgggcg     4260

aactgtattc cttttaacag atccaaacta ttttacattt aaaaaaaaag ttaaactaaa     4320

cttctttact gctgatatgt ttcctgtatt ctagaaaaat ttttacactt tcacattatt     4380

tttgtacact ttccccatgt taagggatga tggcttttat aaatgtgtat tcattaaatg     4440

ttactttaaa aata                                                       4454


<210>  14
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Lys Thr Cys Ile Asp Ala Leu Pro Leu Thr Met Asn Ser Ser 
1               5                   10                  15      


Glu Lys Gln Glu Thr Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Arg 
            20                  25                  30          


Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Val Val Phe Gly 
        35                  40                  45              


Ser Arg Asn Pro Gln Lys Thr Thr Leu Leu Pro Ser Gly Ala Glu Val 
    50                  55                  60                  


Leu Ser Tyr Ser Glu Ala Ala Lys Lys Ser Gly Ile Ile Ile Ile Ala 
65                  70                  75                  80  


Ile His Arg Glu His Tyr Asp Phe Leu Thr Glu Leu Thr Glu Val Leu 
                85                  90                  95      


Asn Gly Lys Ile Leu Val Asp Ile Ser Asn Asn Leu Lys Ile Asn Gln 
            100                 105                 110         


Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala His Leu Val Pro Gly Ala 
        115                 120                 125             


His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser 
    130                 135                 140                 


Gly Ala Leu Asp Ala Ser Arg Gln Val Phe Val Cys Gly Asn Asp Ser 
145                 150                 155                 160 


Lys Ala Lys Gln Arg Val Met Asp Ile Val Arg Asn Leu Gly Leu Thr 
                165                 170                 175     


Pro Met Asp Gln Gly Ser Leu Met Ala Ala Lys Glu Ile Glu Lys Tyr 
            180                 185                 190         


Pro Leu Gln Leu Phe Pro Met Trp Arg Phe Pro Phe Tyr Leu Ser Ala 
        195                 200                 205             


Val Leu Cys Val Phe Leu Phe Phe Tyr Cys Val Ile Arg Asp Val Ile 
    210                 215                 220                 


Tyr Pro Tyr Val Tyr Glu Lys Lys Asp Asn Thr Phe Arg Met Ala Ile 
225                 230                 235                 240 


Ser Ile Pro Asn Arg Ile Phe Pro Ile Thr Ala Leu Thr Leu Leu Ala 
                245                 250                 255     


Leu Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Leu Gln Leu Tyr Arg 
            260                 265                 270         


Gly Thr Lys Tyr Arg Arg Phe Pro Asp Trp Leu Asp His Trp Met Leu 
        275                 280                 285             


Cys Arg Lys Gln Leu Gly Leu Val Ala Leu Gly Phe Ala Phe Leu His 
    290                 295                 300                 


Val Leu Tyr Thr Leu Val Ile Pro Ile Arg Tyr Tyr Val Arg Trp Arg 
305                 310                 315                 320 


Leu Gly Asn Leu Thr Val Thr Gln Ala Ile Leu Lys Lys Glu Asn Pro 
                325                 330                 335     


Phe Ser Thr Ser Ser Ala Trp Leu Ser Asp Ser Tyr Val Ala Leu Gly 
            340                 345                 350         


Ile Leu Gly Phe Phe Leu Phe Val Leu Leu Gly Ile Thr Ser Leu Pro 
        355                 360                 365             


Ser Val Ser Asn Ala Val Asn Trp Arg Glu Phe Arg Phe Val Gln Ser 
    370                 375                 380                 


Lys Leu Gly Tyr Leu Thr Leu Ile Leu Cys Thr Ala His Thr Leu Val 
385                 390                 395                 400 


Tyr Gly Gly Lys Arg Phe Leu Ser Pro Ser Asn Leu Arg Trp Tyr Leu 
                405                 410                 415     


Pro Ala Ala Tyr Val Leu Gly Leu Ile Ile Pro Cys Thr Val Leu Val 
            420                 425                 430         


Ile Lys Phe Val Leu Ile Met Pro Cys Val Asp Asn Thr Leu Thr Arg 
        435                 440                 445             


Ile Arg Gln Gly Trp Glu Arg Asn Ser Lys His 
    450                 455                 


<210>  15
<211>  844
<212>  DNA
<213>  Homo sapiens

<400>  15
cagacacaga gtaaactttt gctgggctcc aagtgaccgc ccatagttta ttataaaggt       60

gactgcaccc tgcagccacc agcactgcct ggctccacgt gcctcctggt ctcagtatgg      120

cgctgtcctg ggttcttaca gtcctgagcc tcctacctct gctggaagcc cagatcccat      180

tgtgtgccaa cctagtaccg gtgcccatca ccaacgccac cctggaccgg atcactggca      240

agtggtttta tatcgcatcg gcctttcgaa acgaggagta caataagtcg gttcaggaga      300

tccaagcaac cttcttttac tttaccccca acaagacaga ggacacgatc tttctcagag      360

agtaccagac ccgccagaac cagtgcttct ataactccag ttacctgaat gtccagcggg      420

agaatgggac cgtctccaga tacgagggag gccgagaaca tgttgctcac ctgctgttcc      480

ttagggacac caagaccttg atgtttggtt cctacctgga cgatgagaag aactgggggc      540

tgtctttcta tgctgacaag ccagagacga ccaaggagca actgggagag ttctacgaag      600

ctctcgactg cttgtgcatt cccaggtcag atgtcatgta caccgactgg aaaaaggata      660

agtgtgagcc actggagaag cagcacgaga aggagaggaa acaggaggag ggggaatcct      720

agcaggacac agccttggat caggacagag acttgggggc catcctgccc ctccaacccg      780

acatgtgtac ctcagctttt tccctcactt gcatcaataa agcttctgtg tttggaacag      840

ctaa                                                                   844


<210>  16
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Arg Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asn Gln Cys Phe Tyr Asn Ser Ser Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Val Ser Arg Tyr Glu Gly Gly 
            100                 105                 110         


Arg Glu His Val Ala His Leu Leu Phe Leu Arg Asp Thr Lys Thr Leu 
        115                 120                 125             


Met Phe Gly Ser Tyr Leu Asp Asp Glu Lys Asn Trp Gly Leu Ser Phe 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Cys Ile Pro Arg Ser Asp Val Met Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  17
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  17
actcgccacc tcctcttcca cccctgccag gcccagcagc caccacagcg cctgcttcct       60

cggccctgaa atcatgcccc taggtctcct gtggctgggc ctagccctgt tgggggctct      120

gcatgcccag gcccaggact ccacctcaga cctgatccca gccccacctc tgagcaaggt      180

ccctctgcag cagaacttcc aggacaacca attccagggg aagtggtatg tggtaggcct      240

ggcagggaat gcaattctca gagaagacaa agacccgcaa aagatgtatg ccaccatcta      300

tgagctgaaa gaagacaaga gctacaatgt cacctccgtc ctgtttagga aaaagaagtg      360

tgactactgg atcaggactt ttgttccagg ttgccagccc ggcgagttca cgctgggcaa      420

cattaagagt taccctggat taacgagtta cctcgtccga gtggtgagca ccaactacaa      480

ccagcatgct atggtgttct tcaagaaagt ttctcaaaac agggagtact tcaagatcac      540

cctctacggg agaaccaagg agctgacttc ggaactaaag gagaacttca tccgcttctc      600

caaatctctg ggcctccctg aaaaccacat cgtcttccct gtcccaatcg accagtgtat      660

cgacggctga gtgcacaggt gccgccagct gccgcaccag cccgaacacc attgagggag      720

ctgggagacc ctccccacag tgccacccat gcagctgctc cccaggccac cccgctgatg      780

gagccccacc ttgtctgcta aataaacatg tgccctcagg ccaaaaaaaa aaaaaaaaaa      840


<210>  18
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  19
<211>  3623
<212>  DNA
<213>  Homo sapiens

<400>  19
tctagcacag gggatcccca aacatcagga cttttggggg gcgcctgtgc tgtccatggg       60

aagagcatgc attgtgggtt actggaggaa cccgacatgg attccacaga gagctggatt      120

gaaagatgtc tcaacgaaag tgaaaacaaa cgttattcca gccacacatc tctggggaat      180

gtttctaatg atgaaaatga ggaaaaagaa aataatagag catccaagcc ccactccact      240

cctgctactc tgcaatggct ggaggagaac tatgagattg cagagggggt ctgcatccct      300

cgcagtgccc tctatatgca ttacctggat ttctgcgaga agaatgatac ccaacctgtc      360

aatgctgcca gctttggaaa gatcataagg cagcagtttc ctcagttaac caccagaaga      420

ctcgggaccc gaggacagtc aaagtaccat tactatggca ttgcagtgaa agaaagctcc      480

caatattatg atgtgatgta ttccaagaaa ggagctgcct gggtgagtga gacgggcaag      540

aaagaagtga gcaaacagac agtggcatat tcaccccggt ccaaactcgg aacactgctg      600

ccagaatttc ccaatgtcaa agatctaaat ctgccagcca gcctgcctga ggagaaggtt      660

tctaccttta ttatgatgta cagaacacac tgtcagagaa tactggacac tgtaataaga      720

gccaactttg atgaggttca aagtttcctt ctgcactttt ggcaaggaat gccgccccac      780

atgctgcctg tgctgggctc ctccacggtg gtgaacattg tcggcgtgtg tgactccatc      840

ctctacaaag ctatctccgg ggtgctgatg cccactgtgc tgcaggcatt acctgacagc      900

ttaactcagg tgattcgaaa gtttgccaag caactggatg agtggctaaa agtggctctc      960

cacgacctcc cagaaaactt gcgaaacatc aagttcgaat tgtcgagaag gttctcccaa     1020

attctgagac ggcaaacatc actaaatcat ctctgccagg catctcgaac agtgatccac     1080

agtgcagaca tcacgttcca aatgctggaa gactggagga acgtggacct gaacagcatc     1140

accaagcaaa ccctttacac catggaagac tctcgcgatg agcaccggaa actcatcacc     1200

caattatatc aggagtttga ccatctcttg gaggagcagt ctcccatcga gtcctacatt     1260

gagtggctgg ataccatggt tgaccgctgt gttgtgaagg tggctgccaa gagacaaggg     1320

tccttgaaga aagtggccca gcagttcctc ttgatgtggt cctgtttcgg cacaagggtg     1380

atccgggaca tgaccttgca cagcgccccc agcttcgggt cttttcacct aattcactta     1440

atgtttgatg actacgtgct ctacctgtta gaatctctgc actgtcagga gcgggccaat     1500

gagctcatgc gagccatgaa gggagaagga agcactgcag aagtccgaga agagatcatc     1560

ttgacagagg ctgccgcacc aaccccttca ccagtgccat cgttttctcc agcaaaatct     1620

gccacatctg tggaagtgcc acctccctct tcccctgtta gcaatccttc ccctgagtac     1680

actggcctca gcactacagg agcaatgcag tcttacacgt ggtctctaac atacacagtg     1740

acgacggctg ctgggtcccc agctgagaac tcccaacagc tgccctgtat gaggaacact     1800

catgtgcctt cttcctccgt cacacacagg ataccagttt atccccacag agaggaacat     1860

ggatacacgg gaagctataa ctatgggagc tatggcaacc agcatcctca ccccatgcag     1920

agccagtatc cggccctccc tcatgacaca gctatctctg ggccactcca ctatgcccct     1980

taccacagga gctctgcaca gtaccctttt aatagcccca cttcccggat ggaaccttgt     2040

ttgatgagca gtactcccag actgcatcct accccagtca ctccccgctg gccagaggtg     2100

ccctcagcca acacgtgcta cacaagcccg tctgtgcatt ctgcgaggta cggaaactct     2160

agtgacatgt atacacctct gacaacgcgc aggaattctg aatatgagca catgcaacac     2220

tttcctggct ttgcttacat caacggagag gcctctacag gatgggctaa atgactgcta     2280

tcataggcat ccatatttaa tattaataat aataattaat aataataata aacccaacac     2340

ccatccccca gaagacttta tctctataca ttgtaactca tgggctattc ctaagtgccc     2400

attttcctaa tgaacatgag gatgggatca atgtgggatg aataaacttt agttcagaaa     2460

caggacttac taaaagtcag tgggactggg tttctgtagc caagccagac ttgactgttt     2520

ctgtagagca ctatctcggg caggccattc tgtgcctttt ccctctgttc catgactttg     2580

ctttgtgttg gcaaccactt ctagtaagct actgattttc ctgttgacaa aatctcttta     2640

gtcttgaagg atggatactg gagacagaat ctggtttgtg ttcttggatg ggcacataat     2700

ttaccaagag cattcacctt gccatctgtc ttgtcattgt actgtacaag gaacagccct     2760

cagacgtgtt ctgcacatcc cttcttcctg gtggtaccat ccctatttcc tggagcacca     2820

gggctaaatg gggagctatc tggaaactct agattttctg tcatacccac atctgtcaca     2880

gtacctgcat tgtcttggaa tgtaagcact gtcttgaggg aaggaagagg tctgttctgt     2940

attgccttaa gttgattgag gtttgtagga gactggttct tctacataca aggatttgtc     3000

ttaagtttgc acaatggcta gtgtcagcaa aaggcaggag agggtttttg tttttttttt     3060

aagttctatg agaatgtgga tttatggcat tgagtatcac actcagctct gctgtgttaa     3120

ctttgtgaaa ctggatggaa caaactttaa cttaccaagc accaagtgtg aaagtgactt     3180

tcacggttcc ttcataaaac tataataata tccgacactt tgatagaaaa aaattcaaag     3240

ctgtgccttt gagcctatac tatactgtgt atgtgtggaa ataaaaatgt attgtacttt     3300

tggagaattt tttgtaggca tttttctgtc agatttgtag taatttgtga ggtttgttag     3360

agattaatat aggttttctt tctgtattat aaaatgcacc aagcaattat ggtggaccta     3420

ttaccctatg ggtaagaaat aaatggaaat atgacatcgg atgtttcagc aactgttctg     3480

taaataaaat ctttgatcac accactcagt gtgataattg tgtctacagc taaaatggaa     3540

atagttttat ctgtacagtt gtgcaagata tgaatggttt cacactcaaa taaaaaatat     3600

tgaaacgaaa aaaaaaaaaa aaa                                             3623


<210>  20
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asn Trp Ala Ala Phe Gly Gly Ser Glu Phe Phe Ile Pro Glu Gly 
1               5                   10                  15      


Ile Gln Ile Asp Ser Arg Cys Pro Leu Ser Arg Asn Ile Thr Glu Trp 
            20                  25                  30          


Tyr His Tyr Tyr Gly Ile Ala Val Lys Glu Ser Ser Gln Tyr Tyr Asp 
        35                  40                  45              


Val Met Tyr Ser Lys Lys Gly Ala Ala Trp Val Ser Glu Thr Gly Lys 
    50                  55                  60                  


Lys Glu Val Ser Lys Gln Thr Val Ala Tyr Ser Pro Arg Ser Lys Leu 
65                  70                  75                  80  


Gly Thr Leu Leu Pro Glu Phe Pro Asn Val Lys Asp Leu Asn Leu Pro 
                85                  90                  95      


Ala Ser Leu Pro Glu Glu Lys Val Ser Thr Phe Ile Met Met Tyr Arg 
            100                 105                 110         


Thr His Cys Gln Arg Ile Leu Asp Thr Val Ile Arg Ala Asn Phe Asp 
        115                 120                 125             


Glu Val Gln Ser Phe Leu Leu His Phe Trp Gln Gly Met Pro Pro His 
    130                 135                 140                 


Met Leu Pro Val Leu Gly Ser Ser Thr Val Val Asn Ile Val Gly Val 
145                 150                 155                 160 


Cys Asp Ser Ile Leu Tyr Lys Ala Ile Ser Gly Val Leu Met Pro Thr 
                165                 170                 175     


Val Leu Gln Ala Leu Pro Asp Ser Leu Thr Gln Val Ile Arg Lys Phe 
            180                 185                 190         


Ala Lys Gln Leu Asp Glu Trp Leu Lys Val Ala Leu His Asp Leu Pro 
        195                 200                 205             


Glu Asn Leu Arg Asn Ile Lys Phe Glu Leu Ser Arg Arg Phe Ser Gln 
    210                 215                 220                 


Ile Leu Arg Arg Gln Thr Ser Leu Asn His Leu Cys Gln Ala Ser Arg 
225                 230                 235                 240 


Thr Val Ile His Ser Ala Asp Ile Thr Phe Gln Met Leu Glu Asp Trp 
                245                 250                 255     


Arg Asn Val Asp Leu Asn Ser Ile Thr Lys Gln Thr Leu Tyr Thr Met 
            260                 265                 270         


Glu Asp Ser Arg Asp Glu His Arg Lys Leu Ile Thr Gln Leu Tyr Gln 
        275                 280                 285             


Glu Phe Asp His Leu Leu Glu Glu Gln Ser Pro Ile Glu Ser Tyr Ile 
    290                 295                 300                 


Glu Trp Leu Asp Thr Met Val Asp Arg Cys Val Val Lys Val Ala Ala 
305                 310                 315                 320 


Lys Arg Gln Gly Ser Leu Lys Lys Val Ala Gln Gln Phe Leu Leu Met 
                325                 330                 335     


Trp Ser Cys Phe Gly Thr Arg Val Ile Arg Asp Met Thr Leu His Ser 
            340                 345                 350         


Ala Pro Ser Phe Gly Ser Phe His Leu Ile His Leu Met Phe Asp Asp 
        355                 360                 365             


Tyr Val Leu Tyr Leu Leu Glu Ser Leu His Cys Gln Glu Arg Ala Asn 
    370                 375                 380                 


Glu Leu Met Arg Ala Met Lys Gly Glu Gly Ser Thr Ala Glu Val Arg 
385                 390                 395                 400 


Glu Glu Ile Ile Leu Thr Glu Ala Ala Ala Pro Thr Pro Ser Pro Val 
                405                 410                 415     


Pro Ser Phe Ser Pro Ala Lys Ser Ala Thr Ser Val Glu Val Pro Pro 
            420                 425                 430         


Pro Ser Ser Pro Val Ser Asn Pro Ser Pro Glu Tyr Thr Gly Leu Ser 
        435                 440                 445             


Thr Thr Gly Ala Met Gln Ser Tyr Thr Trp Ser Leu Thr Tyr Thr Val 
    450                 455                 460                 


Thr Thr Ala Ala Gly Ser Pro Ala Glu Asn Ser Gln Gln Leu Pro Cys 
465                 470                 475                 480 


Met Arg Asn Thr His Val Pro Ser Ser Ser Val Thr His Arg Ile Pro 
                485                 490                 495     


Val Tyr Pro His Arg Glu Glu His Gly Tyr Thr Gly Ser Tyr Asn Tyr 
            500                 505                 510         


Gly Ser Tyr Gly Asn Gln His Pro His Pro Met Gln Ser Gln Tyr Pro 
        515                 520                 525             


Ala Leu Pro His Asp Thr Ala Ile Ser Gly Pro Leu His Tyr Ala Pro 
    530                 535                 540                 


Tyr His Arg Ser Ser Ala Gln Tyr Pro Phe Asn Ser Pro Thr Ser Arg 
545                 550                 555                 560 


Met Glu Pro Cys Leu Met Ser Ser Thr Pro Arg Leu His Pro Thr Pro 
                565                 570                 575     


Val Thr Pro Arg Trp Pro Glu Val Pro Ser Ala Asn Thr Cys Tyr Thr 
            580                 585                 590         


Ser Pro Ser Val His Ser Ala Arg Tyr Gly Asn Ser Ser Asp Met Tyr 
        595                 600                 605             


Thr Pro Leu Thr Thr Arg Arg Asn Ser Glu Tyr Glu His Met Gln His 
    610                 615                 620                 


Phe Pro Gly Phe Ala Tyr Ile Asn Gly Glu Ala Ser Thr Gly Trp Ala 
625                 630                 635                 640 


Lys 
    


<210>  21
<211>  3476
<212>  DNA
<213>  Homo sapiens

<400>  21
atccccgcct gacgggagct agccctcagt ccgcccgagc tgtggttgtg ggcgccggac       60

aagtccaagg cgcctcctcc caatatggac agccgctaca acagcactgc gggcatcggg      120

gacttgaacc agctgagcgc tgccatcccg gccacgcggg tggaggtgtc cgtgtcctgc      180

agaaatcttc ttgacagaga cacattttct aaatctgatc caatttgtgt cttatatgta      240

caaggagttg gaaataaaga atggagagag tttggaagaa ctgaagtaat tgataatact      300

ttaaatcctg attttgtaag aaagtttatt ctggactact tttttgaaga aagagagaat      360

cttcgttttg acttgtatga tgttgattca aagagcccca acttatccaa acatgacttt      420

ctgggacaag tgttttgtac attgggagag atcgttggtt cacagggaag tcgcctggaa      480

aaaccaatag taggaattcc agggaagaaa tgtggtacaa tcatacttac agcagaggaa      540

ttaaactgtt gcagggatgc cgttttgatg caattttgtg cgaacaaatt ggacaagaag      600

gacttctttg gaaaatcaga tcctttcctt gtattttatc gaagtaatga agatggcagt      660

tttacaattt gtcacaagac agaagttgtc aaaaacactc taaatccagt atggcaagca      720

ttcaagatct cagtcagagc attatgtaat ggagactatg acagaacaat caaagtagag      780

gtgtatgact gggaccgaga tggaagtcat gatttcattg gagaatttac aacaagctat      840

agggaacttt ctagagggca gtcacaattc aacgtatatg aggtggtgaa tcccaaaaag      900

aaaggaaaaa agaaaaaata tactaattct ggaacagtaa ctttactctc tttcttggta      960

gaaacagaag tttcattcct tgactacatt aagggaggga cgcaaatcaa tttcacagtg     1020

gctattgatt ttacagcatc aaacggcaac cctgctcagc ccacttccct ccactacatg     1080

aatccttacc aactgaatgc ctatggtatg gcactaaaag cagtgggaga aattgttcaa     1140

gattatgaca gtgataaaat gtttccagct ctaggatttg gtgcaaaact gcctccagat     1200

ggaaggatat ctcacgaatt tgctttgaat gggaatcctc aaaaccccta ctgtgatggc     1260

attgaggggg tcatggaggc ttattacagg agtctgaaat ctgtacaact atatgggccc     1320

accaactttg ctcctgtaat taatcatgta gcaagatatg cttcttctgt aaaggatggc     1380

tcccagtatt ttgtgcttct gattgttaca gatggtgtta tctcagatat ggcccagact     1440

aaggagtcca tagttaatgc ctcaaaactt ccaatgtcaa taattatagt aggtgttgga     1500

ccagcagaat ttgatgcaat ggtcgaattg gatggagatg atgtaagagt ctcctctaga     1560

ggaaaatatg ctgaaagaga cattgtgcag tttgtgccat tcagggatta tattgacaga     1620

agtggaaacc acatactgag catggctaga ttggctaaag atgtcctagc tgagatccct     1680

gagcagtttc tctcctatat gagagcccga ggaatcaagc catcacctgc gcctccccca     1740

tacaccccac ctacacatgt gttacagact caaatatgac tgtgctctga aatgctaatg     1800

tcaactacaa atcaaaagtg ctgagttaat gctttgtgcc tggtgctctg taatgaacca     1860

ggcaatgaga tagttttctc agtttggttt cagcagttaa tgtgctttct tggatccaaa     1920

tttaaatatc ttcctaaacc aaaactgtaa atatggttgt tgcatgagca acagaaaaaa     1980

ttgtttaaat gcttgaagca aagtatggat gtcttctcta aatctttctt tctttttttt     2040

tttaacagaa acagctaatt tccaatgtat tgttgggaaa aagcacaaac tgtgttttta     2100

actcaaatat tgtcttcgac tgctatgtgt ataggaaagc agtctctgta tcaatgttta     2160

catgttacta ctttttaaat ttcaatactt ttataactgt tcttaaaaat aagagtttta     2220

aatactgaat cctttgtctt ctaaattgca atagctataa tcacaagagc aatatctctt     2280

tgaatgactg tctggacaaa cacaattgca aataagggaa gggaaaaatg cttttctatt     2340

tttcagtaac tggattgtct taagaaacta catctgctta ataaacaatt tctcagcaat     2400

gtttgctggg tatgggagtt taagcccggc agatgtgtct cctggttgaa catgcatttt     2460

tcatggagtt tgggttctaa atttagactg cagttggttt gtattttgta acactaagta     2520

gaaattataa aaagtcaaac attgtgatct ataaatgcac agaaaatact ttgtaaaaag     2580

tagcatcctt atataataat gctatttaga aagactgaaa ccaagactat ttaactgtga     2640

actatgtagc agatgtttta aactttttat tccattatat cttgtctaga tattttaatt     2700

caaagggata ctggctctct tgatcggaat ttcttgttat caccattcca cgttgccaca     2760

caaggtgcac aggctggaag tcttttgtga aattcccagt taaatatata caactatgtg     2820

acttagtgca caacacattt gtgaaataac ctactcctat atactgacct gcctgtccac     2880

gaataattgt aaagggtttt tgcatgtaca gtttttacaa gaattacagt tttgtgaagt     2940

tgtgtctaaa ttaaagcatt tctttagaac aaatggcctt aaattctcac ggaattcctg     3000

gaaatgattg tgaattgcct tcaaataata gaaaagtgta tttatttgtg tgtgtgtgtg     3060

tgtcaaaaat gtaactgctt tataatattt tttccttacc tatatattct atttaatact     3120

tggtttattt ctactgtaca ttgttttctt tgtcccaagt tgacctaggg tgacttttat     3180

aagcatgaaa ctattttact ggaaagaaaa atatatacat ccacatatct aacagtatca     3240

atgttatata actatgtaat aattgttgat ttttaattat gtattaaaat ctttaaatca     3300

taactatttg ctttgtacgt ttcatgtatg aatgacaata gtttgatgat ttcctttact     3360

gatcttaaat atttatgcca ctacagtgta ttacctacag atttttaaat ttagctttat     3420

ttatcaaccc aaaaaacaaa taaataagat caatattctt taaaaaaaaa aaaaaa         3476


<210>  22
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Ser Arg Tyr Asn Ser Thr Ala Gly Ile Gly Asp Leu Asn Gln 
1               5                   10                  15      


Leu Ser Ala Ala Ile Pro Ala Thr Arg Val Glu Val Ser Val Ser Cys 
            20                  25                  30          


Arg Asn Leu Leu Asp Arg Asp Thr Phe Ser Lys Ser Asp Pro Ile Cys 
        35                  40                  45              


Val Leu Tyr Val Gln Gly Val Gly Asn Lys Glu Trp Arg Glu Phe Gly 
    50                  55                  60                  


Arg Thr Glu Val Ile Asp Asn Thr Leu Asn Pro Asp Phe Val Arg Lys 
65                  70                  75                  80  


Phe Ile Leu Asp Tyr Phe Phe Glu Glu Arg Glu Asn Leu Arg Phe Asp 
                85                  90                  95      


Leu Tyr Asp Val Asp Ser Lys Ser Pro Asn Leu Ser Lys His Asp Phe 
            100                 105                 110         


Leu Gly Gln Val Phe Cys Thr Leu Gly Glu Ile Val Gly Ser Gln Gly 
        115                 120                 125             


Ser Arg Leu Glu Lys Pro Ile Val Gly Ile Pro Gly Lys Lys Cys Gly 
    130                 135                 140                 


Thr Ile Ile Leu Thr Ala Glu Glu Leu Asn Cys Cys Arg Asp Ala Val 
145                 150                 155                 160 


Leu Met Gln Phe Cys Ala Asn Lys Leu Asp Lys Lys Asp Phe Phe Gly 
                165                 170                 175     


Lys Ser Asp Pro Phe Leu Val Phe Tyr Arg Ser Asn Glu Asp Gly Ser 
            180                 185                 190         


Phe Thr Ile Cys His Lys Thr Glu Val Val Lys Asn Thr Leu Asn Pro 
        195                 200                 205             


Val Trp Gln Ala Phe Lys Ile Ser Val Arg Ala Leu Cys Asn Gly Asp 
    210                 215                 220                 


Tyr Asp Arg Thr Ile Lys Val Glu Val Tyr Asp Trp Asp Arg Asp Gly 
225                 230                 235                 240 


Ser His Asp Phe Ile Gly Glu Phe Thr Thr Ser Tyr Arg Glu Leu Ser 
                245                 250                 255     


Arg Gly Gln Ser Gln Phe Asn Val Tyr Glu Val Val Asn Pro Lys Lys 
            260                 265                 270         


Lys Gly Lys Lys Lys Lys Tyr Thr Asn Ser Gly Thr Val Thr Leu Leu 
        275                 280                 285             


Ser Phe Leu Val Glu Thr Glu Val Ser Phe Leu Asp Tyr Ile Lys Gly 
    290                 295                 300                 


Gly Thr Gln Ile Asn Phe Thr Val Ala Ile Asp Phe Thr Ala Ser Asn 
305                 310                 315                 320 


Gly Asn Pro Ala Gln Pro Thr Ser Leu His Tyr Met Asn Pro Tyr Gln 
                325                 330                 335     


Leu Asn Ala Tyr Gly Met Ala Leu Lys Ala Val Gly Glu Ile Val Gln 
            340                 345                 350         


Asp Tyr Asp Ser Asp Lys Met Phe Pro Ala Leu Gly Phe Gly Ala Lys 
        355                 360                 365             


Leu Pro Pro Asp Gly Arg Ile Ser His Glu Phe Ala Leu Asn Gly Asn 
    370                 375                 380                 


Pro Gln Asn Pro Tyr Cys Asp Gly Ile Glu Gly Val Met Glu Ala Tyr 
385                 390                 395                 400 


Tyr Arg Ser Leu Lys Ser Val Gln Leu Tyr Gly Pro Thr Asn Phe Ala 
                405                 410                 415     


Pro Val Ile Asn His Val Ala Arg Tyr Ala Ser Ser Val Lys Asp Gly 
            420                 425                 430         


Ser Gln Tyr Phe Val Leu Leu Ile Val Thr Asp Gly Val Ile Ser Asp 
        435                 440                 445             


Met Ala Gln Thr Lys Glu Ser Ile Val Asn Ala Ser Lys Leu Pro Met 
    450                 455                 460                 


Ser Ile Ile Ile Val Gly Val Gly Pro Ala Glu Phe Asp Ala Met Val 
465                 470                 475                 480 


Glu Leu Asp Gly Asp Asp Val Arg Val Ser Ser Arg Gly Lys Tyr Ala 
                485                 490                 495     


Glu Arg Asp Ile Val Gln Phe Val Pro Phe Arg Asp Tyr Ile Asp Arg 
            500                 505                 510         


Ser Gly Asn His Ile Leu Ser Met Ala Arg Leu Ala Lys Asp Val Leu 
        515                 520                 525             


Ala Glu Ile Pro Glu Gln Phe Leu Ser Tyr Met Arg Ala Arg Gly Ile 
    530                 535                 540                 


Lys Pro Ser Pro Ala Pro Pro Pro Tyr Thr Pro Pro Thr His Val Leu 
545                 550                 555                 560 


Gln Thr Gln Ile 
                


<210>  23
<211>  3090
<212>  DNA
<213>  Homo sapiens

<400>  23
tttacaaagg ccccgggcgc gagaggacgt gctctgccag ccagtgggaa ggcaggccgc       60

gcgcgcggga gcgcgggagg atcggcggct cgcggtcact ggtccctggc tcggttcccc      120

gcaccccggg gctcacactt acccgcgcgg aggagcagcg gccgggtgtc cacccccatc      180

ctgcgcccag tctcctcgat tcccctcgct ctgagccggg agagccgaac agctgaagag      240

agttcactga ctccccagcc ccaggtgggc cttgtgcaca tcatgaccag ttttgaagat      300

gctgacacag aagagacagt aacttgtctc cagatgacgg tttaccatcc tggccagttg      360

cagtgtggaa tatttcagtc aataagtttt aacagagaga aactcccttc cagcgaagtg      420

gtgaaatttg gccgaaattc caacatctgt cattatactt ttcaggacaa acaggtttcc      480

cgagttcagt tttctctgca gctgtttaaa aaattcaaca gctcagttct ctcctttgaa      540

ataaaaaata tgagtaaaaa gaccaatctg atcgtggaca gcagagagct gggctaccta      600

aataaaatgg acctgccata caggtgcatg gtcagattcg gagagtatca gtttctgatg      660

gagaaggaag atggcgagtc attggaattt tttgagactc aatttatttt atctccaaga      720

tcactcttgc aagaaaacaa ctggccacca cacaggccca taccggagta tggcacttat      780

tcgctctgct cctcccaaag cagttctccg acagaaatgg atgaaaatga gtcatgaaca      840

cagaaagtct aagaggagaa atatgatgga tgaagagctc tgtagatgct gtatagacac      900

taaataagag ttgattaggg tagtatatta tagtcatctg ttatgctgtg aaatttggaa      960

ttcagtatta tcattttgaa gtctgtaaat tgtgttagtc attaacttag tcacctgttg     1020

tattctggat ctacacaaaa ttattttaac tgctcttatt aatctgtgag gattaatata     1080

caaaaagtat cctttgagat gaagtcgtgt tctcaaaata aggttatatt attttctttt     1140

tctgcttgat tttcatcttg tgttttgctt tgtttttgta aggaaccatc tcttggtttg     1200

gtcacatcag ttcacaacag ccatttgttt tcaaggtcaa ggctccaggc aggttgttac     1260

tggtgtttgc agcctgtcag tacttgcagt actggaatag gttctaggct agtgtctgcg     1320

cgtcactgtg gttttagcat gggaggactt atttgagaaa tactacctta cttttctatg     1380

atttcttttt acagagttat agtgtgttta ctcctaagat gacagttctc tttgtctata     1440

ttcagcatct aagacaaata tttaaacatt ttaaagaacc actgtgttaa gtttaggatt     1500

atttacttac caaattagaa gtttgacttt tatgtgttat acacaatctt aaaatttcac     1560

gaattcacct ttttaatagt atccatgtac ataataaaat caaagtttaa ttagccattt     1620

tctttgaatt tttttctaaa taagggaaat aactgttctt gggccacttt acagagataa     1680

atgtatgtga atgtttatga taaacgctta aatatttcta aaatattaac ttcaaaaaag     1740

tctttttcag ttcttaaata aaaatttatt tatttaagat acttattcga cttatcttaa     1800

ctaaggtagc tatgaatgtt aagtagatga ggtaaccatt cagttaagtt aaattgtagc     1860

attgccaggt agtgaggctc actgtacaat tttccaggta aatgaaattt cctgtagtaa     1920

gaggtccgta tttttgtaac agccttttaa aaatgctttt gggaaccctc cagcctctta     1980

ccaaaagagg ctttaaacct catcttgatt cagactgtca gtctattcct gggcagtagt     2040

atgtgatgtc cagcacccta accccgactc cccagccctg ggactattcc agtagagtga     2100

aatatttgtc cctgtacaaa gtggcctgaa tgactgttgg agttcctgtg tctggttttc     2160

ctgtttattc cctgtgatgc ccagagtaat ggcccatcca aagatgtcca gatgtccatg     2220

tgctagtctc cagaacttgt aactgtgttg ttatgtggca aaggggaatg aaggctgcag     2280

atggaagtaa aatagattat gctggattat ctgggtgtgc ccaattgatc accggatccg     2340

taaaagtgga agagaggcag atcaggatgt cagcgtgatg aggtgtgaga cagacttgac     2400

ttgctgttgc tgggaggaag gggaggtcat gagccaagga atgtggacag tctcttgaag     2460

ctggaaagtg tgcattggac atctggaagc cagaaaagac aaagaaatat ccagaaagga     2520

acaaagtctt gtggacacct tgattttggt ccagtgagaa tatgtttgac ttgttaacct     2580

acaaaacttt atgatgataa atttgtgttg gtcgtaagcc actaaatcac agtaatttgt     2640

tatagcagca gatagaaaac taatatactc cctttaatat aaggttatct actattgatt     2700

ctttctagga ttttagcttc tggtctgatg tgggtttaca gccagatcac ccggcttgaa     2760

ttgcttacag tgtgtagtct catggtaaag gcgttctatg agtgaagtgt atatacttta     2820

atgtgtgtat actgtcacat tttgactatt ttggaagact ttcacctctg tttcttgtct     2880

ttgaggctga tgaatgtgtt tctaagttat aaatttaata ttaagggatt catgtattat     2940

tgttattgaa tccaaacaat gtgttaagta atatttaggg ccagaaaaat cttgtacaga     3000

ataatgattt ctcctaatgt aaatcttgga aagggttttg ttcaacttga gaaatattaa     3060

attttttatt ctaaaaaaaa aaaaaaaaaa                                      3090


<210>  24
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Thr Ser Phe Glu Asp Ala Asp Thr Glu Glu Thr Val Thr Cys Leu 
1               5                   10                  15      


Gln Met Thr Val Tyr His Pro Gly Gln Leu Gln Cys Gly Ile Phe Gln 
            20                  25                  30          


Ser Ile Ser Phe Asn Arg Glu Lys Leu Pro Ser Ser Glu Val Val Lys 
        35                  40                  45              


Phe Gly Arg Asn Ser Asn Ile Cys His Tyr Thr Phe Gln Asp Lys Gln 
    50                  55                  60                  


Val Ser Arg Val Gln Phe Ser Leu Gln Leu Phe Lys Lys Phe Asn Ser 
65                  70                  75                  80  


Ser Val Leu Ser Phe Glu Ile Lys Asn Met Ser Lys Lys Thr Asn Leu 
                85                  90                  95      


Ile Val Asp Ser Arg Glu Leu Gly Tyr Leu Asn Lys Met Asp Leu Pro 
            100                 105                 110         


Tyr Arg Cys Met Val Arg Phe Gly Glu Tyr Gln Phe Leu Met Glu Lys 
        115                 120                 125             


Glu Asp Gly Glu Ser Leu Glu Phe Phe Glu Thr Gln Phe Ile Leu Ser 
    130                 135                 140                 


Pro Arg Ser Leu Leu Gln Glu Asn Asn Trp Pro Pro His Arg Pro Ile 
145                 150                 155                 160 


Pro Glu Tyr Gly Thr Tyr Ser Leu Cys Ser Ser Gln Ser Ser Ser Pro 
                165                 170                 175     


Thr Glu Met Asp Glu Asn Glu Ser 
            180                 


<210>  25
<211>  5427
<212>  DNA
<213>  Homo sapiens

<400>  25
atgcagtgga tcttccagtc agattcagag caggagcagg tgaatatttc ccaattttct       60

caattaattg agatcttaaa agaaacccag aataacctca tggaagtaaa ggtcaaatct      120

gagtccccag aaacagtgga ggaagctcaa agaaagtcca cttatgaggt cagcttggct      180

ctcagctgct tcttgaatta tctccaaaaa acagagcaga cagacacaca actcttgcta      240

ctttccattg cagctgctgc aggatatcat gtgatcaaca atacttttca gagtctcttg      300

gggtgtgatg agttaagctt cctactggat gaaatgcaaa ccgcccaaaa taaataccag      360

gagcttaaga atatttgcag ctatagggct caggcattcc tggttctcac aggtctgaca      420

gccacagttg gagacacagc tatttcttca gaagagaaaa cacaacgcat gtcattaatg      480

agacatcaca tgggacaatc attgtccaaa gaagttgcac atgtcctcac caaacctgga      540

gcagatcacg attgggaaaa cctagagaaa gacttgagat tgctcattaa tggggattat      600

gaagaagtca ccatctcttc tttgcaaatg gaagaggtga gcaagcaaag tctcttctat      660

ggaaagaaac agccccatga accacatgac aatgaaaata acaaatggga gatgataaaa      720

aatggagcct tcctagactt actccagcat ctaggtctag aacattacta ccccaaaaaa      780

ttgagcaaag ctaatttcca tctcatctat aagacgtctg tgtataacac ccagcccagc      840

tctgaacagg agcttccctt ctatttcctg cagaaactac tgatgatgga ttatgagctg      900

agatacctag tcttcaaaga tgatagaaac acagaacacc aagtacatcc aaatgcttca      960

gatcaggaag atgaggcttt tgacccatat gaaaactttt ttgaagacag tgatagtccc     1020

actaaatctt catccactga gcctagcccc cacattcacc cagtggatat tcagatgaca     1080

atttttcact gtgcagataa ttttgccaga caatatattt tggccaaact ttccacttgt     1140

cagtttgccc tccccctttt ggtgcctaat ccctgtactt ctcagattga attctctctc     1200

tggtctctcc gtcaaattac aagaagttgg caggaagcaa ggaaatcacc aaaagggaag     1260

aactattata agaatcagca gatgtgctgt gtctctacct caattgtgtc cttcgtaaga     1320

gttggaaatg gcctctctgc ttctaaatct cagattatga actgtcttct cagtaaacgg     1380

aaacatgatg tgttttttca ccgacactgc acaggaagca ggaaagactg cctcttgatg     1440

gggggcatgg tagagatctg ttggttctgt ccaggagggg aagatgagga cagatttgac     1500

aactgtgtga ccttcaccaa tcttcatgga gatgcaaaag aacatgagca gcagctcagc     1560

ttcctgaagg aggtgtctac tgtcattgtg gtcctcatgt cagcctccga tgacaatgaa     1620

ggaaaccgaa aaattgtccg taacttgtgg cagtcatcaa ggccattgat ctgcttgctc     1680

gatgacaaag aagcaaccat gaccaatatt tctggccaaa gaatgagaat gggtatcaag     1740

aatagaaatg aggcagaatt aacagaggaa ctcacaacta caatcagaca tttgctagaa     1800

ctctcagata ctgctctcag cttggaggac tgttcccaga ttgctcacca gcaaggattt     1860

cttatcgatg aagaccagag agactgcaag gaagccaaag aaaaggcaca ggctctaatg     1920

gccttcctgg ggaaaatgaa attatctcag attaaggaaa aattactacc ccttcaggga     1980

caactgtggc accactggtg taagaaggac aaagaactct atcatcttag agaaaaggga     2040

aatcagagca ttgaacaaca caagagtgag attgagacag ataaacaaat aatacggcat     2100

gaacagttgg ccagagccct tcctctcaat gatttaatgc aatctgtcct tcagtttctc     2160

caagagcatt cagaaattca caccaaactg tacttcttgc agtggctgag tgtatttttg     2220

gacaaactga ctgcaggaca cttggaagaa ctgcatgaga agcaaaaata ttggtggtca     2280

ctggttcaaa cagtaaagca aaaggcacct aatagtcact ccctgatatg cctgcaaagt     2340

gagatagaag ccatttccac agagattagt gactgtactt tgggaattga gcaacttatc     2400

agagaagttg gtcagattta tgaagctctg gaagaagctt cctccataaa aaagattttt     2460

ttctcgcttc cccaaattgc cgcagacctg atgatatctg gtgttcccat tgagctgatg     2520

gatggggatg cagcatatgt acctctaaca tgggtggcag ctgtttttga caaggtctct     2580

gagaaacttg gagacaaacg gctatttgtt ctttctatcc ttggcttgca gagctcaggg     2640

aaatccaccg tgctgaatgc cctttttggg cttcagttca ctgttagtgc aggcaaatgt     2700

acccaagggg cctatatgca gctcctcaag gtggaggaga cattcacgga ggaacttggc     2760

tttgactttg tgcttgctgt ggacacagaa ggacttcggg caccagaaca cagcaacaaa     2820

tccaaggata gggacaatga gttggtaact tttgtcattg gacttgcaaa cttgactctg     2880

atcaatattt ttggggagaa tccatcagag atgcaagata tcctacaaat agttgtccaa     2940

gcctttctga gaatgaaaca agtaaaaatc tttccaagtt gcctctttgt ccatcagaat     3000

gtgggggaag ctacagctac ggaccaaact atggatggac gaagacggct agagcagaaa     3060

ctagatgaaa tggcagcaat agctgctgaa caagaacagt gcttagacgt aacctgcttc     3120

agtgatgtca ttaggtttga tgtcaatact cacgtctact actttgctca cctctgggat     3180

ggcaaccccc caatggcccc tcccaatcct cgctacagcc acaatgtaca gcaactgaaa     3240

agtagaattc ttatgactgc cacacaggaa tccaggggaa acatcatgaa gatatcagat     3300

gtaaaatccc gagttcaaga tttgtggaga ggcctgatga acgagaactt tattttcagt     3360

ttcaggaaca cccaagaagt catggccatg aacaaactgg aaaccatgta taaccactgg     3420

acctgggagc tgaggagtca cgtgctgggc ttgcagaacc agctgatcaa ccagattcag     3480

aatggaaaaa tccagacact tgaagcaagc acatttgagg ttctagttac agaaaaatat     3540

gaagttgtca agcaagaact tgaaaaatat tttaatgaag gcccatgtag caaaatactg     3600

attcaatgta aagcaaactt tgaaaataag ctaatagtcc ttaaagaaaa acttatttca     3660

gatagcaaaa gacaagccaa tgaactcatt agttttaaaa accaaagtca agaaaggctg     3720

aataagaaaa agacagatta tgaaaaagaa ttattggaaa aaagccggaa gttggcttta     3780

actgtaaagg gcaaagaatt gagtgaggaa gagttacatg agaaattcaa tcaactttgg     3840

aaaaagtggg tgtgtgatgt atccacaact ctcccgcaag ttacagagcc tgacattgat     3900

ttggattctg aaaacatcct ttgggagtat ttcaaaaaca agacgaatgt cgtgggtcta     3960

ctgacaaatt ctgcagagaa gtttcaaatc aattatgata aacatatcaa ggtgaataag     4020

aaatataacc atatcccaat gacattaaca gtctttgaga aagagttcat taatatgact     4080

actgactaca ttgtttcaag atttaataaa attattaaca acatgtggaa acaacagtgt     4140

ggttacaatc caaattattt ccatgagatt ctaaagacaa tagaagaaga agtgaaatct     4200

gcctctactc agaagagata cacatttaca aatacattta tcattgactt atgtgtgtgt     4260

ttatttcaaa gagcaagaga gaattttaag gaaatgcaca gggcattcaa gagagcaaat     4320

gatcctgtaa actacctaga aagtaagaaa gatgatttct tcacgagttt taagatctcc     4380

tgtcaaggag caacctccat caaaacattt gttgatgttc tgtggtataa gctcactcct     4440

gcagtctcca ctactatatg ggaggacatg acctttaaaa ttgcggggga catgcgagct     4500

acctgccctg cgttcaatgg aaacaggact aacctggaga aacacattct cttctctctg     4560

gcagaagaag aaaactttga taattactgg gaataccttc ataattcaaa atcgtttttt     4620

aggagttaca tcaaaaatca tattaaaaga tattgttcag acaatggagg tgaaaaaatg     4680

aagacttttt ttgaaaaaag cttaattgat atcaagaata ccatcctctc tgccatccat     4740

gaatccacat cagtagctaa agataaaagc agcactgctt ctgagtggtt ggatttattc     4800

tgtgattgcc tggggtgcaa cttgatcttt ccacgaaggg acttgataag cattgaacac     4860

caggagataa aacatactga atttcttaaa gaagccatga gtgcagcttt ggatctcaca     4920

atgaagaaaa tagaacagaa ttattcaagt aagcctatag aagcaatggt ttctaaaatt     4980

gagaaaatgc tctctgaaca tctctgtggc tgctggaaac agtgtcccag ctgtggagca     5040

atttgtacaa acacaattcc tacacatgaa ggagaccata gtgttccctt ccaccgtcct     5100

caggctgtca atggggagga atggtatgaa acagatgatt ttgtcattga ttgctgtact     5160

agtttggttg caagtgattg tttgttggtt ttgagggatg gcaggaattt cccatttaag     5220

aactatcgac aagcaggagg ggattatgcc atgtggagca tcaccccaga tacctccatc     5280

cagctatact ggaaatggtt tgtctctcac ttcagatcaa atctagaaga aaaatatcag     5340

aaaaaatttg caggtaaagg taaaatcccc aatgcatggg ccaaaatcac aaagcaagat     5400

gtgcttgaag acttgaaaaa acagtaa                                         5427


<210>  26
<211>  1808
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gln Trp Ile Phe Gln Ser Asp Ser Glu Gln Glu Gln Val Asn Ile 
1               5                   10                  15      


Ser Gln Phe Ser Gln Leu Ile Glu Ile Leu Lys Glu Thr Gln Asn Asn 
            20                  25                  30          


Leu Met Glu Val Lys Val Lys Ser Glu Ser Pro Glu Thr Val Glu Glu 
        35                  40                  45              


Ala Gln Arg Lys Ser Thr Tyr Glu Val Ser Leu Ala Leu Ser Cys Phe 
    50                  55                  60                  


Leu Asn Tyr Leu Gln Lys Thr Glu Gln Thr Asp Thr Gln Leu Leu Leu 
65                  70                  75                  80  


Leu Ser Ile Ala Ala Ala Ala Gly Tyr His Val Ile Asn Asn Thr Phe 
                85                  90                  95      


Gln Ser Leu Leu Gly Cys Asp Glu Leu Ser Phe Leu Leu Asp Glu Met 
            100                 105                 110         


Gln Thr Ala Gln Asn Lys Tyr Gln Glu Leu Lys Asn Ile Cys Ser Tyr 
        115                 120                 125             


Arg Ala Gln Ala Phe Leu Val Leu Thr Gly Leu Thr Ala Thr Val Gly 
    130                 135                 140                 


Asp Thr Ala Ile Ser Ser Glu Glu Lys Thr Gln Arg Met Ser Leu Met 
145                 150                 155                 160 


Arg His His Met Gly Gln Ser Leu Ser Lys Glu Val Ala His Val Leu 
                165                 170                 175     


Thr Lys Pro Gly Ala Asp His Asp Trp Glu Asn Leu Glu Lys Asp Leu 
            180                 185                 190         


Arg Leu Leu Ile Asn Gly Asp Tyr Glu Glu Val Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Met Glu Glu Val Ser Lys Gln Ser Leu Phe Tyr Gly Lys Lys Gln 
    210                 215                 220                 


Pro His Glu Pro His Asp Asn Glu Asn Asn Lys Trp Glu Met Ile Lys 
225                 230                 235                 240 


Asn Gly Ala Phe Leu Asp Leu Leu Gln His Leu Gly Leu Glu His Tyr 
                245                 250                 255     


Tyr Pro Lys Lys Leu Ser Lys Ala Asn Phe His Leu Ile Tyr Lys Thr 
            260                 265                 270         


Ser Val Tyr Asn Thr Gln Pro Ser Ser Glu Gln Glu Leu Pro Phe Tyr 
        275                 280                 285             


Phe Leu Gln Lys Leu Leu Met Met Asp Tyr Glu Leu Arg Tyr Leu Val 
    290                 295                 300                 


Phe Lys Asp Asp Arg Asn Thr Glu His Gln Val His Pro Asn Ala Ser 
305                 310                 315                 320 


Asp Gln Glu Asp Glu Ala Phe Asp Pro Tyr Glu Asn Phe Phe Glu Asp 
                325                 330                 335     


Ser Asp Ser Pro Thr Lys Ser Ser Ser Thr Glu Pro Ser Pro His Ile 
            340                 345                 350         


His Pro Val Asp Ile Gln Met Thr Ile Phe His Cys Ala Asp Asn Phe 
        355                 360                 365             


Ala Arg Gln Tyr Ile Leu Ala Lys Leu Ser Thr Cys Gln Phe Ala Leu 
    370                 375                 380                 


Pro Leu Leu Val Pro Asn Pro Cys Thr Ser Gln Ile Glu Phe Ser Leu 
385                 390                 395                 400 


Trp Ser Leu Arg Gln Ile Thr Arg Ser Trp Gln Glu Ala Arg Lys Ser 
                405                 410                 415     


Pro Lys Gly Lys Asn Tyr Tyr Lys Asn Gln Gln Met Cys Cys Val Ser 
            420                 425                 430         


Thr Ser Ile Val Ser Phe Val Arg Val Gly Asn Gly Leu Ser Ala Ser 
        435                 440                 445             


Lys Ser Gln Ile Met Asn Cys Leu Leu Ser Lys Arg Lys His Asp Val 
    450                 455                 460                 


Phe Phe His Arg His Cys Thr Gly Ser Arg Lys Asp Cys Leu Leu Met 
465                 470                 475                 480 


Gly Gly Met Val Glu Ile Cys Trp Phe Cys Pro Gly Gly Glu Asp Glu 
                485                 490                 495     


Asp Arg Phe Asp Asn Cys Val Thr Phe Thr Asn Leu His Gly Asp Ala 
            500                 505                 510         


Lys Glu His Glu Gln Gln Leu Ser Phe Leu Lys Glu Val Ser Thr Val 
        515                 520                 525             


Ile Val Val Leu Met Ser Ala Ser Asp Asp Asn Glu Gly Asn Arg Lys 
    530                 535                 540                 


Ile Val Arg Asn Leu Trp Gln Ser Ser Arg Pro Leu Ile Cys Leu Leu 
545                 550                 555                 560 


Asp Asp Lys Glu Ala Thr Met Thr Asn Ile Ser Gly Gln Arg Met Arg 
                565                 570                 575     


Met Gly Ile Lys Asn Arg Asn Glu Ala Glu Leu Thr Glu Glu Leu Thr 
            580                 585                 590         


Thr Thr Ile Arg His Leu Leu Glu Leu Ser Asp Thr Ala Leu Ser Leu 
        595                 600                 605             


Glu Asp Cys Ser Gln Ile Ala His Gln Gln Gly Phe Leu Ile Asp Glu 
    610                 615                 620                 


Asp Gln Arg Asp Cys Lys Glu Ala Lys Glu Lys Ala Gln Ala Leu Met 
625                 630                 635                 640 


Ala Phe Leu Gly Lys Met Lys Leu Ser Gln Ile Lys Glu Lys Leu Leu 
                645                 650                 655     


Pro Leu Gln Gly Gln Leu Trp His His Trp Cys Lys Lys Asp Lys Glu 
            660                 665                 670         


Leu Tyr His Leu Arg Glu Lys Gly Asn Gln Ser Ile Glu Gln His Lys 
        675                 680                 685             


Ser Glu Ile Glu Thr Asp Lys Gln Ile Ile Arg His Glu Gln Leu Ala 
    690                 695                 700                 


Arg Ala Leu Pro Leu Asn Asp Leu Met Gln Ser Val Leu Gln Phe Leu 
705                 710                 715                 720 


Gln Glu His Ser Glu Ile His Thr Lys Leu Tyr Phe Leu Gln Trp Leu 
                725                 730                 735     


Ser Val Phe Leu Asp Lys Leu Thr Ala Gly His Leu Glu Glu Leu His 
            740                 745                 750         


Glu Lys Gln Lys Tyr Trp Trp Ser Leu Val Gln Thr Val Lys Gln Lys 
        755                 760                 765             


Ala Pro Asn Ser His Ser Leu Ile Cys Leu Gln Ser Glu Ile Glu Ala 
    770                 775                 780                 


Ile Ser Thr Glu Ile Ser Asp Cys Thr Leu Gly Ile Glu Gln Leu Ile 
785                 790                 795                 800 


Arg Glu Val Gly Gln Ile Tyr Glu Ala Leu Glu Glu Ala Ser Ser Ile 
                805                 810                 815     


Lys Lys Ile Phe Phe Ser Leu Pro Gln Ile Ala Ala Asp Leu Met Ile 
            820                 825                 830         


Ser Gly Val Pro Ile Glu Leu Met Asp Gly Asp Ala Ala Tyr Val Pro 
        835                 840                 845             


Leu Thr Trp Val Ala Ala Val Phe Asp Lys Val Ser Glu Lys Leu Gly 
    850                 855                 860                 


Asp Lys Arg Leu Phe Val Leu Ser Ile Leu Gly Leu Gln Ser Ser Gly 
865                 870                 875                 880 


Lys Ser Thr Val Leu Asn Ala Leu Phe Gly Leu Gln Phe Thr Val Ser 
                885                 890                 895     


Ala Gly Lys Cys Thr Gln Gly Ala Tyr Met Gln Leu Leu Lys Val Glu 
            900                 905                 910         


Glu Thr Phe Thr Glu Glu Leu Gly Phe Asp Phe Val Leu Ala Val Asp 
        915                 920                 925             


Thr Glu Gly Leu Arg Ala Pro Glu His Ser Asn Lys Ser Lys Asp Arg 
    930                 935                 940                 


Asp Asn Glu Leu Val Thr Phe Val Ile Gly Leu Ala Asn Leu Thr Leu 
945                 950                 955                 960 


Ile Asn Ile Phe Gly Glu Asn Pro Ser Glu Met Gln Asp Ile Leu Gln 
                965                 970                 975     


Ile Val Val Gln Ala Phe Leu Arg Met Lys Gln Val Lys Ile Phe Pro 
            980                 985                 990         


Ser Cys Leu Phe Val His Gln Asn  Val Gly Glu Ala Thr  Ala Thr Asp 
        995                 1000                 1005             


Gln Thr  Met Asp Gly Arg Arg  Arg Leu Glu Gln Lys  Leu Asp Glu 
    1010                 1015                 1020             


Met Ala  Ala Ile Ala Ala Glu  Gln Glu Gln Cys Leu  Asp Val Thr 
    1025                 1030                 1035             


Cys Phe  Ser Asp Val Ile Arg  Phe Asp Val Asn Thr  His Val Tyr 
    1040                 1045                 1050             


Tyr Phe  Ala His Leu Trp Asp  Gly Asn Pro Pro Met  Ala Pro Pro 
    1055                 1060                 1065             


Asn Pro  Arg Tyr Ser His Asn  Val Gln Gln Leu Lys  Ser Arg Ile 
    1070                 1075                 1080             


Leu Met  Thr Ala Thr Gln Glu  Ser Arg Gly Asn Ile  Met Lys Ile 
    1085                 1090                 1095             


Ser Asp  Val Lys Ser Arg Val  Gln Asp Leu Trp Arg  Gly Leu Met 
    1100                 1105                 1110             


Asn Glu  Asn Phe Ile Phe Ser  Phe Arg Asn Thr Gln  Glu Val Met 
    1115                 1120                 1125             


Ala Met  Asn Lys Leu Glu Thr  Met Tyr Asn His Trp  Thr Trp Glu 
    1130                 1135                 1140             


Leu Arg  Ser His Val Leu Gly  Leu Gln Asn Gln Leu  Ile Asn Gln 
    1145                 1150                 1155             


Ile Gln  Asn Gly Lys Ile Gln  Thr Leu Glu Ala Ser  Thr Phe Glu 
    1160                 1165                 1170             


Val Leu  Val Thr Glu Lys Tyr  Glu Val Val Lys Gln  Glu Leu Glu 
    1175                 1180                 1185             


Lys Tyr  Phe Asn Glu Gly Pro  Cys Ser Lys Ile Leu  Ile Gln Cys 
    1190                 1195                 1200             


Lys Ala  Asn Phe Glu Asn Lys  Leu Ile Val Leu Lys  Glu Lys Leu 
    1205                 1210                 1215             


Ile Ser  Asp Ser Lys Arg Gln  Ala Asn Glu Leu Ile  Ser Phe Lys 
    1220                 1225                 1230             


Asn Gln  Ser Gln Glu Arg Leu  Asn Lys Lys Lys Thr  Asp Tyr Glu 
    1235                 1240                 1245             


Lys Glu  Leu Leu Glu Lys Ser  Arg Lys Leu Ala Leu  Thr Val Lys 
    1250                 1255                 1260             


Gly Lys  Glu Leu Ser Glu Glu  Glu Leu His Glu Lys  Phe Asn Gln 
    1265                 1270                 1275             


Leu Trp  Lys Lys Trp Val Cys  Asp Val Ser Thr Thr  Leu Pro Gln 
    1280                 1285                 1290             


Val Thr  Glu Pro Asp Ile Asp  Leu Asp Ser Glu Asn  Ile Leu Trp 
    1295                 1300                 1305             


Glu Tyr  Phe Lys Asn Lys Thr  Asn Val Val Gly Leu  Leu Thr Asn 
    1310                 1315                 1320             


Ser Ala  Glu Lys Phe Gln Ile  Asn Tyr Asp Lys His  Ile Lys Val 
    1325                 1330                 1335             


Asn Lys  Lys Tyr Asn His Ile  Pro Met Thr Leu Thr  Val Phe Glu 
    1340                 1345                 1350             


Lys Glu  Phe Ile Asn Met Thr  Thr Asp Tyr Ile Val  Ser Arg Phe 
    1355                 1360                 1365             


Asn Lys  Ile Ile Asn Asn Met  Trp Lys Gln Gln Cys  Gly Tyr Asn 
    1370                 1375                 1380             


Pro Asn  Tyr Phe His Glu Ile  Leu Lys Thr Ile Glu  Glu Glu Val 
    1385                 1390                 1395             


Lys Ser  Ala Ser Thr Gln Lys  Arg Tyr Thr Phe Thr  Asn Thr Phe 
    1400                 1405                 1410             


Ile Ile  Asp Leu Cys Val Cys  Leu Phe Gln Arg Ala  Arg Glu Asn 
    1415                 1420                 1425             


Phe Lys  Glu Met His Arg Ala  Phe Lys Arg Ala Asn  Asp Pro Val 
    1430                 1435                 1440             


Asn Tyr  Leu Glu Ser Lys Lys  Asp Asp Phe Phe Thr  Ser Phe Lys 
    1445                 1450                 1455             


Ile Ser  Cys Gln Gly Ala Thr  Ser Ile Lys Thr Phe  Val Asp Val 
    1460                 1465                 1470             


Leu Trp  Tyr Lys Leu Thr Pro  Ala Val Ser Thr Thr  Ile Trp Glu 
    1475                 1480                 1485             


Asp Met  Thr Phe Lys Ile Ala  Gly Asp Met Arg Ala  Thr Cys Pro 
    1490                 1495                 1500             


Ala Phe  Asn Gly Asn Arg Thr  Asn Leu Glu Lys His  Ile Leu Phe 
    1505                 1510                 1515             


Ser Leu  Ala Glu Glu Glu Asn  Phe Asp Asn Tyr Trp  Glu Tyr Leu 
    1520                 1525                 1530             


His Asn  Ser Lys Ser Phe Phe  Arg Ser Tyr Ile Lys  Asn His Ile 
    1535                 1540                 1545             


Lys Arg  Tyr Cys Ser Asp Asn  Gly Gly Glu Lys Met  Lys Thr Phe 
    1550                 1555                 1560             


Phe Glu  Lys Ser Leu Ile Asp  Ile Lys Asn Thr Ile  Leu Ser Ala 
    1565                 1570                 1575             


Ile His  Glu Ser Thr Ser Val  Ala Lys Asp Lys Ser  Ser Thr Ala 
    1580                 1585                 1590             


Ser Glu  Trp Leu Asp Leu Phe  Cys Asp Cys Leu Gly  Cys Asn Leu 
    1595                 1600                 1605             


Ile Phe  Pro Arg Arg Asp Leu  Ile Ser Ile Glu His  Gln Glu Ile 
    1610                 1615                 1620             


Lys His  Thr Glu Phe Leu Lys  Glu Ala Met Ser Ala  Ala Leu Asp 
    1625                 1630                 1635             


Leu Thr  Met Lys Lys Ile Glu  Gln Asn Tyr Ser Ser  Lys Pro Ile 
    1640                 1645                 1650             


Glu Ala  Met Val Ser Lys Ile  Glu Lys Met Leu Ser  Glu His Leu 
    1655                 1660                 1665             


Cys Gly  Cys Trp Lys Gln Cys  Pro Ser Cys Gly Ala  Ile Cys Thr 
    1670                 1675                 1680             


Asn Thr  Ile Pro Thr His Glu  Gly Asp His Ser Val  Pro Phe His 
    1685                 1690                 1695             


Arg Pro  Gln Ala Val Asn Gly  Glu Glu Trp Tyr Glu  Thr Asp Asp 
    1700                 1705                 1710             


Phe Val  Ile Asp Cys Cys Thr  Ser Leu Val Ala Ser  Asp Cys Leu 
    1715                 1720                 1725             


Leu Val  Leu Arg Asp Gly Arg  Asn Phe Pro Phe Lys  Asn Tyr Arg 
    1730                 1735                 1740             


Gln Ala  Gly Gly Asp Tyr Ala  Met Trp Ser Ile Thr  Pro Asp Thr 
    1745                 1750                 1755             


Ser Ile  Gln Leu Tyr Trp Lys  Trp Phe Val Ser His  Phe Arg Ser 
    1760                 1765                 1770             


Asn Leu  Glu Glu Lys Tyr Gln  Lys Lys Phe Ala Gly  Lys Gly Lys 
    1775                 1780                 1785             


Ile Pro  Asn Ala Trp Ala Lys  Ile Thr Lys Gln Asp  Val Leu Glu 
    1790                 1795                 1800             


Asp Leu  Lys Lys Gln 
    1805             


<210>  27
<211>  2442
<212>  DNA
<213>  Homo sapiens

<400>  27
ccacgcgtcc ggtggaaata ttttctacac aatgaagtca acaacttaat ttaaaccagt       60

gtttgtgcgg ttctgattca tctgctgtgg ttcccgaagc ttgagatcta aggagtacag      120

ggtcttttgt gatgacaata tgactaatag taaaggaaga tctattaccg ataaaacaag      180

tggtggtcca agtagtggag gaggttttgt agattggact ttacgtttaa acacaattca      240

atccgacaag tttttaaatt tactcttgag tatggttcca gtgatttacc agaaaaacca      300

agaagacagg cacaaaaaag caaacggcat ttggcaagat ggattatcaa ctgcagtaca      360

gacttttagt aatagatctg agcaacacat ggagtatcac agtttctcag agcagtcttt      420

tcatgccaat aatgggcacg catcatcaag ctgcagccaa aagtatgatg actatgccaa      480

ttataattac tgtgatggaa gggagacttc agaaaccact gccatgttac aagatgaaga      540

tatatctagt gatggtgatg aagatgctat tgtagaagtg accccaaaat taccaaagga      600

atccagtggc atcatggcat tgcaaatact tgtgcccttt ttgctagctg gttttggaac      660

agtttcagct ggcatggtac tggatatagt acagcactgg gaggtgttca gaaaagttac      720

agaagttttc attttagtcc ctgcacttct tggtctcaaa gggaacttgg aaatgacatt      780

ggcatccaga ttatccactg cagtaaatat tgggaagatg gattcaccca ttgaaaagtg      840

gaacctaata attggcaact tggctttaaa gcaggttcag gcaacagtag tgggttttct      900

agcagctgtg gcagcaatta tattgggctg gattccagaa ggaaaatatt accttgatca      960

ttccatactt ctgtgctcta gcagtgtggc aactgccttc attgcatctc ttctgcaggg     1020

aataataatg gttggggtta tcgttggttc aaagaagact ggtataaatc ctgataatgt     1080

tgctacaccc attgctgcta gttttggcga ccttataact cttgccatat tggcttggat     1140

aagtcagggc ttatactcct gtcttgagac ctattactac atttctccat tagttggtgt     1200

atttttcttg gctctaaccc ctatttggat tataatagct gccaaacatc cagccacaag     1260

aacagttctc cactcaggct gggagcctgt cataacagct atggttataa gtagcattgg     1320

gggccttatt ctggacacaa ctgtatcaga cccaaacttg gttgggattg ttgtttacac     1380

gccagttatt aatggtattg gtggtaattt ggtggccatt caggctagca ggatttctac     1440

ctacctccat ttacatagca ttccaggaga attgcctgat gaacccaaag gttgttacta     1500

cccatttaga actttctttg gtccaggagt aaataataag tctgctcaag ttctactgct     1560

tttagtgatt cctggacatt taattttcct ctacactatt catttgatga aaagtggtca     1620

tacttcttta actataatct tcatagtagt gtatttattt ggcgctgtgt tacaggtatt     1680

taccttgctg tggattgctg actggatggt ccatcacttc tggaggaaag gaaaggaccc     1740

ggatagtttc tccatcccct acctaacagc attgggtgat ctgctcggga cagctctgtt     1800

agccttaagt tttcattttc tttggcttat tggagatcga gatggagatg ttggagacta     1860

ataaattcta caaactgctc tcaagttacc aaggaagaaa atacacgaca accacttatg     1920

gctctttttc aaaactctta aatcagtagt ttgacttttg ccagggtaat cttcagttgg     1980

ccctgattca attaaatggc cttaattttt ttttaaggaa tttgtgtcaa aaccagaatg     2040

aagagtattc gtgctgcttt tcatagaata aatgataatt tgacatagac atagatataa     2100

gttccagctc tgaaattaat taggaaagaa tataggatgt ttacagtgaa taattttaaa     2160

accacaaaca tagcagaaat gtactttatt attaaatttg taatgcagga ttagaagaag     2220

cagagctcta gtttagcctt tcttgtctca cagatgtgct gtatcccagg catactataa     2280

aacgaagagt gcccaaccaa gctttgaatc gtattaacaa tgcccacctc tatgctagct     2340

gaggataaat ttaccagttg ctcatattta aactgaccta aatatgtttt gctgagcata     2400

agataaactc acttttacct ccatctaaaa aaaaaaaaaa aa                        2442


<210>  28
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Tyr His Ser Phe Ser Glu Gln Ser Phe His Ala Asn Asn Gly 
1               5                   10                  15      


His Ala Ser Ser Ser Cys Ser Gln Lys Tyr Asp Asp Tyr Ala Asn Tyr 
            20                  25                  30          


Asn Tyr Cys Asp Gly Arg Glu Thr Ser Glu Thr Thr Ala Met Leu Gln 
        35                  40                  45              


Asp Glu Asp Ile Ser Ser Asp Gly Asp Glu Asp Ala Ile Val Glu Val 
    50                  55                  60                  


Thr Pro Lys Leu Pro Lys Glu Ser Ser Gly Ile Met Ala Leu Gln Ile 
65                  70                  75                  80  


Leu Val Pro Phe Leu Leu Ala Gly Phe Gly Thr Val Ser Ala Gly Met 
                85                  90                  95      


Val Leu Asp Ile Val Gln His Trp Glu Val Phe Arg Lys Val Thr Glu 
            100                 105                 110         


Val Phe Ile Leu Val Pro Ala Leu Leu Gly Leu Lys Gly Asn Leu Glu 
        115                 120                 125             


Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Val Asn Ile Gly Lys Met 
    130                 135                 140                 


Asp Ser Pro Ile Glu Lys Trp Asn Leu Ile Ile Gly Asn Leu Ala Leu 
145                 150                 155                 160 


Lys Gln Val Gln Ala Thr Val Val Gly Phe Leu Ala Ala Val Ala Ala 
                165                 170                 175     


Ile Ile Leu Gly Trp Ile Pro Glu Gly Lys Tyr Tyr Leu Asp His Ser 
            180                 185                 190         


Ile Leu Leu Cys Ser Ser Ser Val Ala Thr Ala Phe Ile Ala Ser Leu 
        195                 200                 205             


Leu Gln Gly Ile Ile Met Val Gly Val Ile Val Gly Ser Lys Lys Thr 
    210                 215                 220                 


Gly Ile Asn Pro Asp Asn Val Ala Thr Pro Ile Ala Ala Ser Phe Gly 
225                 230                 235                 240 


Asp Leu Ile Thr Leu Ala Ile Leu Ala Trp Ile Ser Gln Gly Leu Tyr 
                245                 250                 255     


Ser Cys Leu Glu Thr Tyr Tyr Tyr Ile Ser Pro Leu Val Gly Val Phe 
            260                 265                 270         


Phe Leu Ala Leu Thr Pro Ile Trp Ile Ile Ile Ala Ala Lys His Pro 
        275                 280                 285             


Ala Thr Arg Thr Val Leu His Ser Gly Trp Glu Pro Val Ile Thr Ala 
    290                 295                 300                 


Met Val Ile Ser Ser Ile Gly Gly Leu Ile Leu Asp Thr Thr Val Ser 
305                 310                 315                 320 


Asp Pro Asn Leu Val Gly Ile Val Val Tyr Thr Pro Val Ile Asn Gly 
                325                 330                 335     


Ile Gly Gly Asn Leu Val Ala Ile Gln Ala Ser Arg Ile Ser Thr Tyr 
            340                 345                 350         


Leu His Leu His Ser Ile Pro Gly Glu Leu Pro Asp Glu Pro Lys Gly 
        355                 360                 365             


Cys Tyr Tyr Pro Phe Arg Thr Phe Phe Gly Pro Gly Val Asn Asn Lys 
    370                 375                 380                 


Ser Ala Gln Val Leu Leu Leu Leu Val Ile Pro Gly His Leu Ile Phe 
385                 390                 395                 400 


Leu Tyr Thr Ile His Leu Met Lys Ser Gly His Thr Ser Leu Thr Ile 
                405                 410                 415     


Ile Phe Ile Val Val Tyr Leu Phe Gly Ala Val Leu Gln Val Phe Thr 
            420                 425                 430         


Leu Leu Trp Ile Ala Asp Trp Met Val His His Phe Trp Arg Lys Gly 
        435                 440                 445             


Lys Asp Pro Asp Ser Phe Ser Ile Pro Tyr Leu Thr Ala Leu Gly Asp 
    450                 455                 460                 


Leu Leu Gly Thr Ala Leu Leu Ala Leu Ser Phe His Phe Leu Trp Leu 
465                 470                 475                 480 


Ile Gly Asp Arg Asp Gly Asp Val Gly Asp 
                485                 490 


<210>  29
<211>  1345
<212>  DNA
<213>  Homo sapiens

<400>  29
ggaacaggat gcccctgtcc cgctggttga gatctgtggg ggtcttcctg ctgccagccc       60

cctactgggc accccgggag aggtggctgg gttccctacg gcggccctcc ctggtgcacg      120

ggtacccagt cctggcctgg cacagtgccc gctgctggtg ccaagcgtgg acagaggaac      180

ctcgagccct ttgctcctcc ctcagaatga acggagacca gaattcagat gtttatgccc      240

aagaaaagca ggatttcgtt cagcacttct cccagatcgt tagggtgctg actgaggatg      300

agatggggca cccagagata ggagatgcta ttgcccggct caaggaggtc ctggagtaca      360

atgccattgg aggcaagtat aaccggggtt tgacggtggt agtagcattc cgggagctgg      420

tggagccaag gaaacaggat gctgatagtc tccagcgggc ctggactgtg ggctggtgtg      480

tggaactgct gcaagctttc ttcctggtgg cagatgacat catggattca tcccttaccc      540

gccggggaca gatctgctgg tatcagaagc cgggcgtggg tttggatgcc atcaatgatg      600

ctaacctcct ggaagcatgt atctaccgcc tgctgaagct ctattgccgg gagcagccct      660

attacctgaa cctgatcgag ctcttcctgc agagttccta tcagactgag attgggcaga      720

ccctggacct cctcacagcc ccccagggca atgtggatct tgtcagattc actgaaaaga      780

ggtacaaatc tattgtcaag tacaagacag ctttctactc cttctacctt cctatagctg      840

cagccatgta catggcagga attgatggcg agaaggagca cgccaatgcc aagaagatcc      900

tgctggagat gggggagttc tttcagattc aggatgatta ccttgacctc tttggggacc      960

ccagtgtgac cggcaaaatt ggcactgaca tccaggacaa caaatgcagc tggctggtgg     1020

ttcagtgtct gcaacgggcc actccagaac agtaccagat cctgaaggaa aattacgggc     1080

agaaggaggc tgagaaagtg gcccgggtga aggcgctata tgaggagctg gatctgccag     1140

cagtgttctt gcaatatgag gaagacagtt acagccacat tatggctctc attgaacagt     1200

acgcagcacc cctgccccca gccgtctttc tggggcttgc gcgcaaaatc tacaagcgga     1260

gaaagtgacc tagagattgc aagggcgggg agaggaggct ctcaataaat aatcgtgtaa     1320

ccttaaaaaa aaaaaaaaaa aaaaa                                           1345


<210>  30
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Pro Leu Ser Arg Trp Leu Arg Ser Val Gly Val Phe Leu Leu Pro 
1               5                   10                  15      


Ala Pro Tyr Trp Ala Pro Arg Glu Arg Trp Leu Gly Ser Leu Arg Arg 
            20                  25                  30          


Pro Ser Leu Val His Gly Tyr Pro Val Leu Ala Trp His Ser Ala Arg 
        35                  40                  45              


Cys Trp Cys Gln Ala Trp Thr Glu Glu Pro Arg Ala Leu Cys Ser Ser 
    50                  55                  60                  


Leu Arg Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys 
65                  70                  75                  80  


Gln Asp Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys 
            100                 105                 110         


Glu Val Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu 
        115                 120                 125             


Thr Val Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp 
    130                 135                 140                 


Ala Asp Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu 
145                 150                 155                 160 


Leu Gln Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu 
                165                 170                 175     


Thr Arg Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu 
            180                 185                 190         


Asp Ala Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu 
        195                 200                 205             


Leu Lys Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu 
    210                 215                 220                 


Leu Phe Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp 
225                 230                 235                 240 


Leu Leu Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu 
                245                 250                 255     


Lys Arg Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe 
            260                 265                 270         


Tyr Leu Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu 
        275                 280                 285             


Lys Glu His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe 
    290                 295                 300                 


Phe Gln Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val 
305                 310                 315                 320 


Thr Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu 
                325                 330                 335     


Val Val Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu 
            340                 345                 350         


Lys Glu Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys 
        355                 360                 365             


Ala Leu Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu 
    370                 375                 380                 


Glu Asp Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala 
385                 390                 395                 400 


Pro Leu Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys 
                405                 410                 415     


Arg Arg Lys 
            


<210>  31
<211>  2150
<212>  DNA
<213>  Homo sapiens

<400>  31
ctcaggttcc cggtgcttcg cgcgtctgcc gttgtcacag gccagggagg tggcaccacc       60

aggcgaagct tggcgagatt gtgtcgtcaa gcgcgtacgg gcgccaattg gccgggcgat      120

gtggcgtgga ctggcgctgg cgcgagcgat tggctgcgcg gcccgggggc ggggccagtg      180

ggcggtgcgc gccgcagact gtgctcaaag cgggcgccat ccgggaccgg cggttgtctg      240

tggccggagg ctgatcagtg ttctagaaca gatcagacat tttgtaatga tgcctgaaat      300

aaacactaac cacctcgaca agcaacaggt tcaactcctg gcagagatgt gtatccttat      360

tgatgaaaat gacaataaaa ttggagctga gaccaagaag aattgtcacc tgaacgagaa      420

cattgagaaa ggattattgc atcgagcttt tagtgtcttc ttattcaaca ccgaaaataa      480

gcttctgcta cagcaaagat cagatgctaa gattaccttt ccaggttgtt ttacgaatac      540

gtgttgtagt catccattaa gcaatccagc cgagcttgag gaaagtgacg cccttggagt      600

gaggcgagca gcacagagac ggctgaaagc tgagctagga attcccttgg aagaggttcc      660

tccagaagaa attaattatt taacacgaat tcactacaaa gctcagtctg atggtatctg      720

gggtgaacat gaaattgatt acattttgtt ggtgaggaag aatgtaactt tgaatccaga      780

tcccaatgag attaaaagct attgttatgt gtcaaaggaa gaactaaaag aacttctgaa      840

aaaagcagcc agtggtgaaa ttaagataac gccatggttt aaaattattg cagcgacttt      900

tctctttaaa tggtgggata acttaaatca tttgaatcag tttgttgacc atgagaaaat      960

atacagaatg tgaatatgta ggtaaatgat tacagaaaaa tttatctgct taacaaactt     1020

agaatgactt tttcctttta aatttagttc tatcattaat ttatcattaa atttagttct     1080

atcatttggt actatcatta atgtattata tacactgata ctttaaaact tgtgtggaaa     1140

aaactaactt ataattttgt atcacacacc ctggatatgt gttctgtttc taagcgacat     1200

ttgtgagaga ttattgtaaa atgagagcga gcaaataaaa cttaatttaa tctttgcaga     1260

tacatactta tgggaaattt gaacaaatga gtgaaactct gtttttagta ggctgtgata     1320

aacatttccg gagcacttgc agaggacttg ctatttgcca ggtgctttat gtatcattaa     1380

atttttctca tagttcagaa aaatgtgcaa aggaaactat tgtctcgctc cttcaaaaca     1440

gtcttaatta actttcatat tagcagatta aactagcaga gcaggttcaa gggaaattaa     1500

atgatatgga ccctaatttg tatcattctg agttgattgt gtggtttatt cattctggaa     1560

acatgttgat acttacagtc agccactgct tttgataagt gatattgatt aggttgaatc     1620

ttcttgtaaa tagtatttac cagttagcaa agtctgtgtt ttcagaatta cagtgagcac     1680

agaggtgttc ataaaatggg aattgagtcc cactcggtaa gagttgctta aacttgacac     1740

tgttgacatt tgggctggat aaaacccctg tggtggggtc tgtgctgtgc attgcaggat     1800

ggtgagcagc gtccctctca tgtgacaccc acagttatgc cggatgttgc cagatgcccc     1860

taggggacag agtcaacccc caactgagga ccactgtcct acagagtcag gaaatattgt     1920

agggagaaaa aaataacaac aacaaaggcc tgtgttaatg ttaaatagat gagattatgg     1980

aatgtgtata ttaatgttaa aaattgtacc ttgatcaatg tactttttat aaacttgcca     2040

tagatatctc agatttgaaa cctcaagaca gatttattat tcttaaatgc tgtatgataa     2100

tgaagaaaaa taaaaattta tttcttgcaa agttaaaaaa aaaaaaaaaa                2150


<210>  32
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Trp Arg Gly Leu Ala Leu Ala Arg Ala Ile Gly Cys Ala Ala Arg 
1               5                   10                  15      


Gly Arg Gly Gln Trp Ala Val Arg Ala Ala Asp Cys Ala Gln Ser Gly 
            20                  25                  30          


Arg His Pro Gly Pro Ala Val Val Cys Gly Arg Arg Leu Ile Ser Val 
        35                  40                  45              


Leu Glu Gln Ile Arg His Phe Val Met Met Pro Glu Ile Asn Thr Asn 
    50                  55                  60                  


His Leu Asp Lys Gln Gln Val Gln Leu Leu Ala Glu Met Cys Ile Leu 
65                  70                  75                  80  


Ile Asp Glu Asn Asp Asn Lys Ile Gly Ala Glu Thr Lys Lys Asn Cys 
                85                  90                  95      


His Leu Asn Glu Asn Ile Glu Lys Gly Leu Leu His Arg Ala Phe Ser 
            100                 105                 110         


Val Phe Leu Phe Asn Thr Glu Asn Lys Leu Leu Leu Gln Gln Arg Ser 
        115                 120                 125             


Asp Ala Lys Ile Thr Phe Pro Gly Cys Phe Thr Asn Thr Cys Cys Ser 
    130                 135                 140                 


His Pro Leu Ser Asn Pro Ala Glu Leu Glu Glu Ser Asp Ala Leu Gly 
145                 150                 155                 160 


Val Arg Arg Ala Ala Gln Arg Arg Leu Lys Ala Glu Leu Gly Ile Pro 
                165                 170                 175     


Leu Glu Glu Val Pro Pro Glu Glu Ile Asn Tyr Leu Thr Arg Ile His 
            180                 185                 190         


Tyr Lys Ala Gln Ser Asp Gly Ile Trp Gly Glu His Glu Ile Asp Tyr 
        195                 200                 205             


Ile Leu Leu Val Arg Lys Asn Val Thr Leu Asn Pro Asp Pro Asn Glu 
    210                 215                 220                 


Ile Lys Ser Tyr Cys Tyr Val Ser Lys Glu Glu Leu Lys Glu Leu Leu 
225                 230                 235                 240 


Lys Lys Ala Ala Ser Gly Glu Ile Lys Ile Thr Pro Trp Phe Lys Ile 
                245                 250                 255     


Ile Ala Ala Thr Phe Leu Phe Lys Trp Trp Asp Asn Leu Asn His Leu 
            260                 265                 270         


Asn Gln Phe Val Asp His Glu Lys Ile Tyr Arg Met 
        275                 280                 


<210>  33
<211>  2989
<212>  DNA
<213>  Homo sapiens

<400>  33
gtctgggccg agcccgccca gctggctgag acgcgtggag cctggcggcg agtgggggcg       60

tgcgacggtt actctggtta ctggggccgc gccgcgctgg cgagagccgc cgcccgcgag      120

ggatgctggt gaggaagccg tcgggagccg ccgccgccat ctgagggagg taccctggaa      180

accacctttt atcggtgggg aagtgcagtc gcggtgggcg gctctggggg ccagcgaaac      240

gggaggcctc taaatcttta ggttggggct gcattgccct ggagccgcac tcttgagtcc      300

gaggccatct tttgttggag aaggcgtcgg cgttggcgtt ttcccgaggt tgggctgtac      360

agtgtctccg tccgcggaaa aagaagcctc tgaacccgcg ccggcccgca gcccccgtgc      420

cttccggccg ctgctcgccg tcgccagagg ctaggccacg tttcccccag tgccgaggtg      480

tttctgtgac cctccctcca ctcccattcc cttctgaaag ggcacctgct cttggtgaga      540

aaagaaatta tagcacgaag agccagtatc agaagagtat ccatcacccg cagcaaccgc      600

tcagggaaca ccatcaaaaa agaaaaaaag ggaatatctg gatttcctgg gcgaggagga      660

gcgagtctgc tcgggagctg ttccagcagg cgatttttaa atactgcttt ctacgcccta      720

tacaacttgg cttcacatac ttttacacta actttatatg atttttaaaa actggtctga      780

tcggacttct cgtcctggga cactgtttac tggagtctgg ccggctctcc gtgctcctct      840

tggtacctca ttttggggag aaccttaaac ccactcgagc agataatctc cgccttgacc      900

ggtgccacca aagaagcctt ggaaccatgt ggacttttct gggcattgcc actttcacct      960

atttttataa gaagttcggg gacttcatca ctttggccaa cagggaggtc ctgttgtgcg     1020

tgctggtgtt cctctcgctg ggcctggtgc tctcctaccg ctgtcgccac cgaaacgggg     1080

gtctcctcgg gcgccagcag agcggctccc agttcgccct cttctcggat attctctcag     1140

gcctgccttt cattggcttc ttctgggcca aatccccccc tgaatcagaa aataaggagc     1200

agctcgaggc caggaggcgc agaaaaggaa ccaatatttc agaaacaagc ttaataggaa     1260

cagctgcctg tacatcaaca tcttctcaga atgacccaga agttatcatc gtgggagctg     1320

gcgtgcttgg ctctgctttg gcagctgtgc tttccagaga tggaagaaag gtgacagtca     1380

ttgagagaga cttaaaagag cctgacagaa tagttggaga attcctgcag ccgggtggtt     1440

atcatgttct caaagacctt ggtcttggag atacagtgga aggtcttgat gcccaggttg     1500

taaatggtta catgattcat gatcaggaaa gcaaatcaga ggttcagatt ccttaccctc     1560

tgtcagaaaa caatcaagtg cagagtggaa gagctttcca tcacggaaga ttcatcatga     1620

gtctccggaa agcagctatg gcagagccca atgcaaagtt tattgaaggt gttgtgttac     1680

agttattaga ggaagatgat gttgtgatgg gagttcagta caaggataaa gagactggag     1740

atatcaagga actccatgct ccactgactg ttgttgcaga tgggcttttc tccaagttca     1800

ggaaaagcct ggtctccaat aaagtttctg tatcatctca ttttgttggc tttcttatga     1860

agaatgcacc acagtttaaa gcaaatcatg ctgaacttat tttagctaac ccgagtccag     1920

ttctcatcta ccagatttca tccagtgaaa ctcgagtact tgttgacatt agaggagaaa     1980

tgccaaggaa tttaagagaa tacatggttg aaaaaattta cccacaaata cctgatcacc     2040

tgaaagaacc attcttagaa gccactgaca attctcatct gaggtccatg ccagcaagct     2100

tccttcctcc ttcatcagtg aagaaacgag gtgttcttct tttgggagac gcatataata     2160

tgaggcatcc acttactggt ggaggaatga ctgttgcttt taaagatata aaactatgga     2220

gaaaactgct aaagggtatc cctgaccttt atgatgatgc agctattttc gaggccaaaa     2280

aatcatttta ctgggcaaga aaaacatctc attcctttgt cgtgaatatc cttgctcagg     2340

ctctttatga attattttct gccacagatg attccctgca tcaactaaga aaagcctgtt     2400

ttctttattt caaacttggt ggcgaatgtg ttgcgggtcc tgttgggctg ctttctgtat     2460

tgtctcctaa ccctctagtt ttaattggac acttctttgc tgttgcaatc tatgccgtgt     2520

atttttgctt taagtcagaa ccttggatta caaaacctcg agcccttctc agtagtggtg     2580

ctgtattgta caaagcgtgt tctgtaatat ttcctctaat ttactcagaa atgaagtata     2640

tggttcatta agcttaaagg ggaaccattt gtgaatgaat atttggaact taccaagtcc     2700

taagagactt ttggaagagg atatatatag catagtacca taccacttat aaagtggaaa     2760

ctcttggacc aagatttgga ttaatttgtt tttgaagttt tttgtatata aatatgtaaa     2820

tacatgcttt aatttgcaat ttaaaatgaa ggggttaaat aagttagaca tttaaaagaa     2880

atgattgtta ccataaatta gtgctaatgc tgaggagaac tacagttttt cttttgaatt     2940

tagtatttga gatgagttgt tgggacatgc aaataaaatg aagaatgaa                 2989


<210>  34
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Trp Thr Phe Leu Gly Ile Ala Thr Phe Thr Tyr Phe Tyr Lys Lys 
1               5                   10                  15      


Phe Gly Asp Phe Ile Thr Leu Ala Asn Arg Glu Val Leu Leu Cys Val 
            20                  25                  30          


Leu Val Phe Leu Ser Leu Gly Leu Val Leu Ser Tyr Arg Cys Arg His 
        35                  40                  45              


Arg Asn Gly Gly Leu Leu Gly Arg Gln Gln Ser Gly Ser Gln Phe Ala 
    50                  55                  60                  


Leu Phe Ser Asp Ile Leu Ser Gly Leu Pro Phe Ile Gly Phe Phe Trp 
65                  70                  75                  80  


Ala Lys Ser Pro Pro Glu Ser Glu Asn Lys Glu Gln Leu Glu Ala Arg 
                85                  90                  95      


Arg Arg Arg Lys Gly Thr Asn Ile Ser Glu Thr Ser Leu Ile Gly Thr 
            100                 105                 110         


Ala Ala Cys Thr Ser Thr Ser Ser Gln Asn Asp Pro Glu Val Ile Ile 
        115                 120                 125             


Val Gly Ala Gly Val Leu Gly Ser Ala Leu Ala Ala Val Leu Ser Arg 
    130                 135                 140                 


Asp Gly Arg Lys Val Thr Val Ile Glu Arg Asp Leu Lys Glu Pro Asp 
145                 150                 155                 160 


Arg Ile Val Gly Glu Phe Leu Gln Pro Gly Gly Tyr His Val Leu Lys 
                165                 170                 175     


Asp Leu Gly Leu Gly Asp Thr Val Glu Gly Leu Asp Ala Gln Val Val 
            180                 185                 190         


Asn Gly Tyr Met Ile His Asp Gln Glu Ser Lys Ser Glu Val Gln Ile 
        195                 200                 205             


Pro Tyr Pro Leu Ser Glu Asn Asn Gln Val Gln Ser Gly Arg Ala Phe 
    210                 215                 220                 


His His Gly Arg Phe Ile Met Ser Leu Arg Lys Ala Ala Met Ala Glu 
225                 230                 235                 240 


Pro Asn Ala Lys Phe Ile Glu Gly Val Val Leu Gln Leu Leu Glu Glu 
                245                 250                 255     


Asp Asp Val Val Met Gly Val Gln Tyr Lys Asp Lys Glu Thr Gly Asp 
            260                 265                 270         


Ile Lys Glu Leu His Ala Pro Leu Thr Val Val Ala Asp Gly Leu Phe 
        275                 280                 285             


Ser Lys Phe Arg Lys Ser Leu Val Ser Asn Lys Val Ser Val Ser Ser 
    290                 295                 300                 


His Phe Val Gly Phe Leu Met Lys Asn Ala Pro Gln Phe Lys Ala Asn 
305                 310                 315                 320 


His Ala Glu Leu Ile Leu Ala Asn Pro Ser Pro Val Leu Ile Tyr Gln 
                325                 330                 335     


Ile Ser Ser Ser Glu Thr Arg Val Leu Val Asp Ile Arg Gly Glu Met 
            340                 345                 350         


Pro Arg Asn Leu Arg Glu Tyr Met Val Glu Lys Ile Tyr Pro Gln Ile 
        355                 360                 365             


Pro Asp His Leu Lys Glu Pro Phe Leu Glu Ala Thr Asp Asn Ser His 
    370                 375                 380                 


Leu Arg Ser Met Pro Ala Ser Phe Leu Pro Pro Ser Ser Val Lys Lys 
385                 390                 395                 400 


Arg Gly Val Leu Leu Leu Gly Asp Ala Tyr Asn Met Arg His Pro Leu 
                405                 410                 415     


Thr Gly Gly Gly Met Thr Val Ala Phe Lys Asp Ile Lys Leu Trp Arg 
            420                 425                 430         


Lys Leu Leu Lys Gly Ile Pro Asp Leu Tyr Asp Asp Ala Ala Ile Phe 
        435                 440                 445             


Glu Ala Lys Lys Ser Phe Tyr Trp Ala Arg Lys Thr Ser His Ser Phe 
    450                 455                 460                 


Val Val Asn Ile Leu Ala Gln Ala Leu Tyr Glu Leu Phe Ser Ala Thr 
465                 470                 475                 480 


Asp Asp Ser Leu His Gln Leu Arg Lys Ala Cys Phe Leu Tyr Phe Lys 
                485                 490                 495     


Leu Gly Gly Glu Cys Val Ala Gly Pro Val Gly Leu Leu Ser Val Leu 
            500                 505                 510         


Ser Pro Asn Pro Leu Val Leu Ile Gly His Phe Phe Ala Val Ala Ile 
        515                 520                 525             


Tyr Ala Val Tyr Phe Cys Phe Lys Ser Glu Pro Trp Ile Thr Lys Pro 
    530                 535                 540                 


Arg Ala Leu Leu Ser Ser Gly Ala Val Leu Tyr Lys Ala Cys Ser Val 
545                 550                 555                 560 


Ile Phe Pro Leu Ile Tyr Ser Glu Met Lys Tyr Met Val His 
                565                 570                 


<210>  35
<211>  428
<212>  DNA
<213>  Homo sapiens

<400>  35
atgtctcttg tcagctgtct ttcagaagac ctggtggggc aagtccgtgg gcatcatgtt       60

gaccgagctg gagaaagcct tgaactctat catcgacgtc taccacaagt actccctgat      120

aaaggggaat ttccatgccg tctacaggga tgacctgaag aaattgctag agaccgagtg      180

tcctcagtat atcaggaaaa agggtgcaga cgtctggttc aaagagttgg atatcaacac      240

tgatggtgca gttaacttcc aggagttcct cattctggtg ataaagatgg gcgtggcagc      300

ccacaaaaaa agccatgaag aaagccacaa agagtagctg agttactggg cccagaggct      360

gggcccctgg acatgtacct gcagaataat aaagtcatca atacctcaaa aaaaaaaaaa      420

aaaaaaaa                                                               428


<210>  36
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
1               5                   10                  15      


His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
            20                  25                  30          


Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
        35                  40                  45              


Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
    50                  55                  60                  


Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
65                  70                  75                  80  


Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                85                  90              


<210>  37
<211>  586
<212>  DNA
<213>  Homo sapiens

<400>  37
aaacactctg tgtggctcct cggctttgac agagtgcaag acgatgactt gcaaaatgtc       60

gcagctggaa cgcaacatag agaccatcat caacaccttc caccaatact ctgtgaagct      120

ggggcaccca gacaccctga accaggggga attcaaagag ctggtgcgaa aagatctgca      180

aaattttctc aagaaggaga ataagaatga aaaggtcata gaacacatca tggaggacct      240

ggacacaaat gcagacaagc agctgagctt cgaggagttc atcatgctga tggcgaggct      300

aacctgggcc tcccacgaga agatgcacga gggtgacgag ggccctggcc accaccataa      360

gccaggcctc ggggagggca ccccctaaga ccacagtggc caagatcaca gtggccacgg      420

ccacggccac agtcatggtg gccacggcca cagccactaa tcaggaggcc aggccaccct      480

gcctctaccc aaccagggcc ccggggcctg ttatgtcaaa ctgtcttggc tgtggggcta      540

ggggctgggg ccaaataaag tctcttcctc caagtcaaaa aaaaaa                     586


<210>  38
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210>  39
<211>  2620
<212>  DNA
<213>  Homo sapiens

<400>  39
agatgcgagc actgcggctg ggcgctgagg atcagccgct tcctgcctgg attccacagc       60

ttcgcgccgt gtactgtcgc cccatccctg cgcgcccagc ctgccaagca gcgtgccccg      120

gttgcaggcg tcatgcagcg ggcgcgaccc acgctctggg ccgctgcgct gactctgctg      180

gtgctgctcc gcgggccgcc ggtggcgcgg gctggcgcga gctcggcggg cttgggtccc      240

gtggtgcgct gcgagccgtg cgacgcgcgt gcactggccc agtgcgcgcc tccgcccgcc      300

gtgtgcgcgg agctggtgcg cgagccgggc tgcggctgct gcctgacgtg cgcactgagc      360

gagggccagc cgtgcggcat ctacaccgag cgctgtggct ccggccttcg ctgccagccg      420

tcgcccgacg aggcgcgacc gctgcaggcg ctgctggacg gccgcgggct ctgcgtcaac      480

gctagtgccg tcagccgcct gcgcgcctac ctgctgccag cgccgccagc tccaggaaat      540

gctagtgagt cggaggaaga ccgcagcgcc ggcagtgtgg agagcccgtc cgtctccagc      600

acgcaccggg tgtctgatcc caagttccac cccctccatt caaagataat catcatcaag      660

aaagggcatg ctaaagacag ccagcgctac aaagttgact acgagtctca gagcacagat      720

acccagaact tctcctccga gtccaagcgg gagacagaat atggtccctg ccgtagagaa      780

atggaagaca cactgaatca cctgaagttc ctcaatgtgc tgagtcccag gggtgtacac      840

attcccaact gtgacaagaa gggattttat aagaaaaagc agtgtcgccc ttccaaaggc      900

aggaagcggg gcttctgctg gtgtgtggat aagtatgggc agcctctccc aggctacacc      960

accaagggga aggaggacgt gcactgctac agcatgcaga gcaagtagac gcctgccgca     1020

aggttaatgt ggagctcaaa tatgccttat tttgcacaaa agactgccaa ggacatgacc     1080

agcagctggc tacagcctcg atttatattt ctgtttgtgg tgaactgatt ttttttaaac     1140

caaagtttag aaagaggttt ttgaaatgcc tatggtttct ttgaatggta aacttgagca     1200

tcttttcact ttccagtagt cagcaaagag cagtttgaat tttcttgtcg cttcctatca     1260

aaatattcag agactcgagc acagcaccca gacttcatgc gcccgtggaa tgctcaccac     1320

atgttggtcg aagcggccga ccactgactt tgtgacttag gcggctgtgt tgcctatgta     1380

gagaacacgc ttcaccccca ctccccgtac agtgcgcaca ggctttatcg agaataggaa     1440

aacctttaaa ccccggtcat ccggacatcc caacgcatgc tcctggagct cacagccttc     1500

tgtggtgtca tttctgaaac aagggcgtgg atccctcaac caagaagaat gtttatgtct     1560

tcaagtgacc tgtactgctt ggggactatt ggagaaaata aggtggagtc ctacttgttt     1620

aaaaaatatg tatctaagaa tgttctaggg cactctggga acctataaag gcaggtattt     1680

cgggccctcc tcttcaggaa tcttcctgaa gacatggccc agtcgaaggc ccaggatggc     1740

ttttgctgcg gccccgtggg gtaggaggga cagagagaca gggagagtca gcctccacat     1800

tcagaggcat cacaagtaat ggcacaattc ttcggatgac tgcagaaaat agtgttttgt     1860

agttcaacaa ctcaagacga agcttatttc tgaggataag ctctttaaag gcaaagcttt     1920

attttcatct ctcatctttt gtcctcctta gcacaatgta aaaaagaata gtaatatcag     1980

aacaggaagg aggaatggct tgctggggag cccatccagg acactgggag cacatagaga     2040

ttcacccatg tttgttgaac ttagagtcat tctcatgctt ttctttataa ttcacacata     2100

tatgcagaga agatatgttc ttgttaacat tgtatacaac atagccccaa atatagtaag     2160

atctatacta gataatccta gatgaaatgt tagagatgct atatgataca actgtggcca     2220

tgactgagga aaggagctca cgcccagaga ctgggctgct ctcccggagg ccaaacccaa     2280

gaaggtctgg caaagtcagg ctcagggaga ctctgccctg ctgcagacct cggtgtggac     2340

acacgctgca tagagctctc cttgaaaaca gaggggtctc aagacattct gcctacctat     2400

tagcttttct ttattttttt aactttttgg ggggaaaagt atttttgaga agtttgtctt     2460

gcaatgtatt tataaatagt aaataaagtt tttaccatta aaaaaatatc tttccctttg     2520

ttattgacca tctctgggct ttgtatcact aattatttta ttttattata taataattat     2580

tttattataa taaaatcctg aaaggggaaa ataaaaaaaa                           2620


<210>  40
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 
    130                 135                 140                 


Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 
145                 150                 155                 160 


Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 
                165                 170                 175     


Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 
        275                 280                 285             


Gln Ser Lys 
    290     


<210>  41
<211>  1103
<212>  DNA
<213>  Homo sapiens

<400>  41
cacagagccc gggccgcagg cacctcctcg ccagctcttc cgctcctctc acagccgcca       60

gacccgcctg ctgagcccca tggcccgcgc tgctctctcc gccgccccca gcaatccccg      120

gctcctgcga gtggcactgc tgctcctgct cctggtagcc gctggccggc gcgcagcagg      180

agcgtccgtg gccactgaac tgcgctgcca gtgcttgcag accctgcagg gaattcaccc      240

caagaacatc caaagtgtga acgtgaagtc ccccggaccc cactgcgccc aaaccgaagt      300

catagccaca ctcaagaatg ggcggaaagc ttgcctcaat cctgcatccc ccatagttaa      360

gaaaatcatc gaaaagatgc tgaacagtga caaatccaac tgaccagaag ggaggaggaa      420

gctcactggt ggctgttcct gaaggaggcc ctgcccttat aggaacagaa gaggaaagag      480

agacacagct gcagaggcca cctggattgt gcctaatgtg tttgagcatc gcttaggaga      540

agtcttctat ttatttattt attcattagt tttgaagatt ctatgttaat attttaggtg      600

taaaataatt aagggtatga ttaactctac ctgcacactg tcctattata ttcattcttt      660

ttgaaatgtc aaccccaagt tagttcaatc tggattcata tttaatttga aggtagaatg      720

ttttcaaatg ttctccagtc attatgttaa tatttctgag gagcctgcaa catgccagcc      780

actgtgatag aggctggcgg atccaagcaa atggccaatg agatcattgt gaaggcaggg      840

gaatgtatgt gcacatctgt tttgtaactg tttagatgaa tgtcagttgt tatttattga      900

aatgatttca cagtgtgtgg tcaacatttc tcatgttgaa actttaagaa ctaaaatgtt      960

ctaaatatcc cttggacatt ttatgtcttt cttgtaaggc atactgcctt gtttaatggt     1020

agttttacag tgtttctggc ttagaacaaa ggggcttaat tattgatgtt ttcatagaga     1080

atataaaaat aaagcactta tag                                             1103


<210>  42
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  43
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  43
aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca       60

gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc      120

ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc      180

cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg      240

ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc      300

cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg      360

acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg      420

acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga      480

tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca      540

gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg      600

gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga      660

ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc      720

aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc      780

caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga      840

cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga      900

agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga      960

agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg     1020

gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat     1080

gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg     1140

tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag     1200

acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc     1260

agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt     1320

ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa     1380

gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac     1440

actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat     1500

gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat     1560

cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat     1620

tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag     1680

ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat     1740

tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt     1800

ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg     1860

tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg     1920

tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct     1980

gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta     2040

tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga     2100

ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa     2160

tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc     2220

tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt     2280

gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta     2340

taaaaaaaaa aaaaaaaa                                                   2358


<210>  44
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  45
<211>  14121
<212>  DNA
<213>  Homo sapiens

<400>  45
attcccaccg ggacctgcgg ggctgagtgc ccttctcggt tgctgccgct gaggagcccg       60

cccagccagc cagggccgcg aggccgaggc caggccgcag cccaggagcc gccccaccgc      120

agctggcgat ggacccgccg aggcccgcgc tgctggcgct gctggcgctg cctgcgctgc      180

tgctgctgct gctggcgggc gccagggccg aagaggaaat gctggaaaat gtcagcctgg      240

tctgtccaaa agatgcgacc cgattcaagc acctccggaa gtacacatac aactatgagg      300

ctgagagttc cagtggagtc cctgggactg ctgattcaag aagtgccacc aggatcaact      360

gcaaggttga gctggaggtt ccccagctct gcagcttcat cctgaagacc agccagtgca      420

ccctgaaaga ggtgtatggc ttcaaccctg agggcaaagc cttgctgaag aaaaccaaga      480

actctgagga gtttgctgca gccatgtcca ggtatgagct caagctggcc attccagaag      540

ggaagcaggt tttcctttac ccggagaaag atgaacctac ttacatcctg aacatcaaga      600

ggggcatcat ttctgccctc ctggttcccc cagagacaga agaagccaag caagtgttgt      660

ttctggatac cgtgtatgga aactgctcca ctcactttac cgtcaagacg aggaagggca      720

atgtggcaac agaaatatcc actgaaagag acctggggca gtgtgatcgc ttcaagccca      780

tccgcacagg catcagccca cttgctctca tcaaaggcat gacccgcccc ttgtcaactc      840

tgatcagcag cagccagtcc tgtcagtaca cactggacgc taagaggaag catgtggcag      900

aagccatctg caaggagcaa cacctcttcc tgcctttctc ctacaagaat aagtatggga      960

tggtagcaca agtgacacag actttgaaac ttgaagacac accaaagatc aacagccgct     1020

tctttggtga aggtactaag aagatgggcc tcgcatttga gagcaccaaa tccacatcac     1080

ctccaaagca ggccgaagct gttttgaaga ctctccagga actgaaaaaa ctaaccatct     1140

ctgagcaaaa tatccagaga gctaatctct tcaataagct ggttactgag ctgagaggcc     1200

tcagtgatga agcagtcaca tctctcttgc cacagctgat tgaggtgtcc agccccatca     1260

ctttacaagc cttggttcag tgtggacagc ctcagtgctc cactcacatc ctccagtggc     1320

tgaaacgtgt gcatgccaac ccccttctga tagatgtggt cacctacctg gtggccctga     1380

tccccgagcc ctcagcacag cagctgcgag agatcttcaa catggcgagg gatcagcgca     1440

gccgagccac cttgtatgcg ctgagccacg cggtcaacaa ctatcataag acaaacccta     1500

cagggaccca ggagctgctg gacattgcta attacctgat ggaacagatt caagatgact     1560

gcactgggga tgaagattac acctatttga ttctgcgggt cattggaaat atgggccaaa     1620

ccatggagca gttaactcca gaactcaagt cttcaatcct gaaatgtgtc caaagtacaa     1680

agccatcact gatgatccag aaagctgcca tccaggctct gcggaaaatg gagcctaaag     1740

acaaggacca ggaggttctt cttcagactt tccttgatga tgcttctccg ggagataagc     1800

gactggctgc ctatcttatg ttgatgagga gtccttcaca ggcagatatt aacaaaattg     1860

tccaaattct accatgggaa cagaatgagc aagtgaagaa ctttgtggct tcccatattg     1920

ccaatatctt gaactcagaa gaattggata tccaagatct gaaaaagtta gtgaaagaag     1980

ctctgaaaga atctcaactt ccaactgtca tggacttcag aaaattctct cggaactatc     2040

aactctacaa atctgtttct cttccatcac ttgacccagc ctcagccaaa atagaaggga     2100

atcttatatt tgatccaaat aactaccttc ctaaagaaag catgctgaaa actaccctca     2160

ctgcctttgg atttgcttca gctgacctca tcgagattgg cttggaagga aaaggctttg     2220

agccaacatt ggaagctctt tttgggaagc aaggattttt cccagacagt gtcaacaaag     2280

ctttgtactg ggttaatggt caagttcctg atggtgtctc taaggtctta gtggaccact     2340

ttggctatac caaagatgat aaacatgagc aggatatggt aaatggaata atgctcagtg     2400

ttgagaagct gattaaagat ttgaaatcca aagaagtccc ggaagccaga gcctacctcc     2460

gcatcttggg agaggagctt ggttttgcca gtctccatga cctccagctc ctgggaaagc     2520

tgcttctgat gggtgcccgc actctgcagg ggatccccca gatgattgga gaggtcatca     2580

ggaagggctc aaagaatgac ttttttcttc actacatctt catggagaat gcctttgaac     2640

tccccactgg agctggatta cagttgcaaa tatcttcatc tggagtcatt gctcccggag     2700

ccaaggctgg agtaaaactg gaagtagcca acatgcaggc tgaactggtg gcaaaaccct     2760

ccgtgtctgt ggagtttgtg acaaatatgg gcatcatcat tccggacttc gctaggagtg     2820

gggtccagat gaacaccaac ttcttccacg agtcgggtct ggaggctcat gttgccctaa     2880

aagctgggaa gctgaagttt atcattcctt ccccaaagag accagtcaag ctgctcagtg     2940

gaggcaacac attacatttg gtctctacca ccaaaacgga ggtgatccca cctctcattg     3000

agaacaggca gtcctggtca gtttgcaagc aagtctttcc tggcctgaat tactgcacct     3060

caggcgctta ctccaacgcc agctccacag actccgcctc ctactatccg ctgaccgggg     3120

acaccagatt agagctggaa ctgaggccta caggagagat tgagcagtat tctgtcagcg     3180

caacctatga gctccagaga gaggacagag ccttggtgga taccctgaag tttgtaactc     3240

aagcagaagg tgcgaagcag actgaggcta ccatgacatt caaatataat cggcagagta     3300

tgaccttgtc cagtgaagtc caaattccgg attttgatgt tgacctcgga acaatcctca     3360

gagttaatga tgaatctact gagggcaaaa cgtcttacag actcaccctg gacattcaga     3420

acaagaaaat tactgaggtc gccctcatgg gccacctaag ttgtgacaca aaggaagaaa     3480

gaaaaatcaa gggtgttatt tccatacccc gtttgcaagc agaagccaga agtgagatcc     3540

tcgcccactg gtcgcctgcc aaactgcttc tccaaatgga ctcatctgct acagcttatg     3600

gctccacagt ttccaagagg gtggcatggc attatgatga agagaagatt gaatttgaat     3660

ggaacacagg caccaatgta gataccaaaa aaatgacttc caatttccct gtggatctct     3720

ccgattatcc taagagcttg catatgtatg ctaatagact cctggatcac agagtccctc     3780

aaacagacat gactttccgg cacgtgggtt ccaaattaat agttgcaatg agctcatggc     3840

ttcagaaggc atctgggagt cttccttata cccagacttt gcaagaccac ctcaatagcc     3900

tgaaggagtt caacctccag aacatgggat tgccagactt ccacatccca gaaaacctct     3960

tcttaaaaag cgatggccgg gtcaaatata ccttgaacaa gaacagtttg aaaattgaga     4020

ttcctttgcc ttttggtggc aaatcctcca gagatctaaa gatgttagag actgttagga     4080

caccagccct ccacttcaag tctgtgggat tccatctgcc atctcgagag ttccaagtcc     4140

ctacttttac cattcccaag ttgtatcaac tgcaagtgcc tctcctgggt gttctagacc     4200

tctccacgaa tgtctacagc aacttgtaca actggtccgc ctcctacagt ggtggcaaca     4260

ccagcacaga ccatttcagc cttcgggctc gttaccacat gaaggctgac tctgtggttg     4320

acctgctttc ctacaatgtg caaggatctg gagaaacaac atatgaccac aagaatacgt     4380

tcacactatc atgtgatggg tctctacgcc acaaatttct agattcgaat atcaaattca     4440

gtcatgtaga aaaacttgga aacaacccag tctcaaaagg tttactaata ttcgatgcat     4500

ctagttcctg gggaccacag atgtctgctt cagttcattt ggactccaaa aagaaacagc     4560

atttgtttgt caaagaagtc aagattgatg ggcagttcag agtctcttcg ttctatgcta     4620

aaggcacata tggcctgtct tgtcagaggg atcctaacac tggccggctc aatggagagt     4680

ccaacctgag gtttaactcc tcctacctcc aaggcaccaa ccagataaca ggaagatatg     4740

aagatggaac cctctccctc acctccacct ctgatctgca aagtggcatc attaaaaata     4800

ctgcttccct aaagtatgag aactacgagc tgactttaaa atctgacacc aatgggaagt     4860

ataagaactt tgccacttct aacaagatgg atatgacctt ctctaagcaa aatgcactgc     4920

tgcgttctga atatcaggct gattacgagt cattgaggtt cttcagcctg ctttctggat     4980

cactaaattc ccatggtctt gagttaaatg ctgacatctt aggcactgac aaaattaata     5040

gtggtgctca caaggcgaca ctaaggattg gccaagatgg aatatctacc agtgcaacga     5100

ccaacttgaa gtgtagtctc ctggtgctgg agaatgagct gaatgcagag cttggcctct     5160

ctggggcatc tatgaaatta acaacaaatg gccgcttcag ggaacacaat gcaaaattca     5220

gtctggatgg gaaagccgcc ctcacagagc tatcactggg aagtgcttat caggccatga     5280

ttctgggtgt cgacagcaaa aacattttca acttcaaggt cagtcaagaa ggacttaagc     5340

tctcaaatga catgatgggc tcatatgctg aaatgaaatt tgaccacaca aacagtctga     5400

acattgcagg cttatcactg gacttctctt caaaacttga caacatttac agctctgaca     5460

agttttataa gcaaactgtt aatttacagc tacagcccta ttctctggta actactttaa     5520

acagtgacct gaaatacaat gctctggatc tcaccaacaa tgggaaacta cggctagaac     5580

ccctgaagct gcatgtggct ggtaacctaa aaggagccta ccaaaataat gaaataaaac     5640

acatctatgc catctcttct gctgccttat cagcaagcta taaagcagac actgttgcta     5700

aggttcaggg tgtggagttt agccatcggc tcaacacaga catcgctggg ctggcttcag     5760

ccattgacat gagcacaaac tataattcag actcactgca tttcagcaat gtcttccgtt     5820

ctgtaatggc cccgtttacc atgaccatcg atgcacatac aaatggcaat gggaaactcg     5880

ctctctgggg agaacatact gggcagctgt atagcaaatt cctgttgaaa gcagaacctc     5940

tggcatttac tttctctcat gattacaaag gctccacaag tcatcatctc gtgtctagga     6000

aaagcatcag tgcagctctt gaacacaaag tcagtgccct gcttactcca gctgagcaga     6060

caggcacctg gaaactcaag acccaattta acaacaatga atacagccag gacttggatg     6120

cttacaacac taaagataaa attggcgtgg agcttactgg acgaactctg gctgacctaa     6180

ctctactaga ctccccaatt aaagtgccac ttttactcag tgagcccatc aatatcattg     6240

atgctttaga gatgagagat gccgttgaga agccccaaga atttacaatt gttgcttttg     6300

taaagtatga taaaaaccaa gatgttcact ccattaacct cccatttttt gagaccttgc     6360

aagaatattt tgagaggaat cgacaaacca ttatagttgt actggaaaac gtacagagaa     6420

acctgaagca catcaatatt gatcaatttg taagaaaata cagagcagcc ctgggaaaac     6480

tcccacagca agctaatgat tatctgaatt cattcaattg ggagagacaa gtttcacatg     6540

ccaaggagaa actgactgct ctcacaaaaa agtatagaat tacagaaaat gatatacaaa     6600

ttgcattaga tgatgccaaa atcaacttta atgaaaaact atctcaactg cagacatata     6660

tgatacaatt tgatcagtat attaaagata gttatgattt acatgatttg aaaatagcta     6720

ttgctaatat tattgatgaa atcattgaaa aattaaaaag tcttgatgag cactatcata     6780

tccgtgtaaa tttagtaaaa acaatccatg atctacattt gtttattgaa aatattgatt     6840

ttaacaaaag tggaagtagt actgcatcct ggattcaaaa tgtggatact aagtaccaaa     6900

tcagaatcca gatacaagaa aaactgcagc agcttaagag acacatacag aatatagaca     6960

tccagcacct agctggaaag ttaaaacaac acattgaggc tattgatgtt agagtgcttt     7020

tagatcaatt gggaactaca atttcatttg aaagaataaa tgacgttctt gagcatgtca     7080

aacactttgt tataaatctt attggggatt ttgaagtagc tgagaaaatc aatgccttca     7140

gagccaaagt ccatgagtta atcgagaggt atgaagtaga ccaacaaatc caggttttaa     7200

tggataaatt agtagagttg gcccaccaat acaagttgaa ggagactatt cagaagctaa     7260

gcaatgtcct acaacaagtt aagataaaag attactttga gaaattggtt ggatttattg     7320

atgatgctgt caagaagctt aatgaattat cttttaaaac attcattgaa gatgttaaca     7380

aattccttga catgttgata aagaaattaa agtcatttga ttaccaccag tttgtagatg     7440

aaaccaatga caaaatccgt gaggtgactc agagactcaa tggtgaaatt caggctctgg     7500

aactaccaca aaaagctgaa gcattaaaac tgtttttaga ggaaaccaag gccacagttg     7560

cagtgtatct ggaaagccta caggacacca aaataacctt aatcatcaat tggttacagg     7620

aggctttaag ttcagcatct ttggctcaca tgaaggccaa attccgagag accctagaag     7680

atacacgaga ccgaatgtat caaatggaca ttcagcagga acttcaacga tacctgtctc     7740

tggtaggcca ggtttatagc acacttgtca cctacatttc tgattggtgg actcttgctg     7800

ctaagaacct tactgacttt gcagagcaat attctatcca agattgggct aaacgtatga     7860

aagcattggt agagcaaggg ttcactgttc ctgaaatcaa gaccatcctt gggaccatgc     7920

ctgcctttga agtcagtctt caggctcttc agaaagctac cttccagaca cctgatttta     7980

tagtccccct aacagatttg aggattccat cagttcagat aaacttcaaa gacttaaaaa     8040

atataaaaat cccatccagg ttttccacac cagaatttac catccttaac accttccaca     8100

ttccttcctt tacaattgac tttgtagaaa tgaaagtaaa gatcatcaga accattgacc     8160

agatgctgaa cagtgagctg cagtggcccg ttccagatat atatctcagg gatctgaagg     8220

tggaggacat tcctctagcg agaatcaccc tgccagactt ccgtttacca gaaatcgcaa     8280

ttccagaatt cataatccca actctcaacc ttaatgattt tcaagttcct gaccttcaca     8340

taccagaatt ccagcttccc cacatctcac acacaattga agtacctact tttggcaagc     8400

tatacagtat tctgaaaatc caatctcctc ttttcacatt agatgcaaat gctgacatag     8460

ggaatggaac cacctcagca aacgaagcag gtatcgcagc ttccatcact gccaaaggag     8520

agtccaaatt agaagttctc aattttgatt ttcaagcaaa tgcacaactc tcaaacccta     8580

agattaatcc gctggctctg aaggagtcag tgaagttctc cagcaagtac ctgagaacgg     8640

agcatgggag tgaaatgctg ttttttggaa atgctattga gggaaaatca aacacagtgg     8700

caagtttaca cacagaaaaa aatacactgg agcttagtaa tggagtgatt gtcaagataa     8760

acaatcagct taccctggat agcaacacta aatacttcca caaattgaac atccccaaac     8820

tggacttctc tagtcaggct gacctgcgca acgagatcaa gacactgttg aaagctggcc     8880

acatagcatg gacttcttct ggaaaagggt catggaaatg ggcctgcccc agattctcag     8940

atgagggaac acatgaatca caaattagtt tcaccataga aggacccctc acttcctttg     9000

gactgtccaa taagatcaat agcaaacacc taagagtaaa ccaaaacttg gtttatgaat     9060

ctggctccct caacttttct aaacttgaaa ttcaatcaca agtcgattcc cagcatgtgg     9120

gccacagtgt tctaactgct aaaggcatgg cactgtttgg agaagggaag gcagagttta     9180

ctgggaggca tgatgctcat ttaaatggaa aggttattgg aactttgaaa aattctcttt     9240

tcttttcagc ccagccattt gagatcacgg catccacaaa caatgaaggg aatttgaaag     9300

ttcgttttcc attaaggtta acagggaaga tagacttcct gaataactat gcactgtttc     9360

tgagtcccag tgcccagcaa gcaagttggc aagtaagtgc taggttcaat cagtataagt     9420

acaaccaaaa tttctctgct ggaaacaacg agaacattat ggaggcccat gtaggaataa     9480

atggagaagc aaatctggat ttcttaaaca ttcctttaac aattcctgaa atgcgtctac     9540

cttacacaat aatcacaact cctccactga aagatttctc tctatgggaa aaaacaggct     9600

tgaaggaatt cttgaaaacg acaaagcaat catttgattt aagtgtaaaa gctcagtata     9660

agaaaaacaa acacaggcat tccatcacaa atcctttggc tgtgctttgt gagtttatca     9720

gtcagagcat caaatccttt gacaggcatt ttgaaaaaaa cagaaacaat gcattagatt     9780

ttgtcaccaa atcctataat gaaacaaaaa ttaagtttga taagtacaaa gctgaaaaat     9840

ctcacgacga gctccccagg acctttcaaa ttcctggata cactgttcca gttgtcaatg     9900

ttgaagtgtc tccattcacc atagagatgt cggcattcgg ctatgtgttc ccaaaagcag     9960

tcagcatgcc tagtttctcc atcctaggtt ctgacgtccg tgtgccttca tacacattaa    10020

tcctgccatc attagagctg ccagtccttc atgtccctag aaatctcaag ctttctcttc    10080

cagatttcaa ggaattgtgt accataagcc atatttttat tcctgccatg ggcaatatta    10140

cctatgattt ctcctttaaa tcaagtgtca tcacactgaa taccaatgct gaacttttta    10200

accagtcaga tattgttgct catctccttt cttcatcttc atctgtcatt gatgcactgc    10260

agtacaaatt agagggcacc acaagattga caagaaaaag gggattgaag ttagccacag    10320

ctctgtctct gagcaacaaa tttgtggagg gtagtcataa cagtactgtg agcttaacca    10380

cgaaaaatat ggaagtgtca gtggcaacaa ccacaaaagc ccaaattcca attttgagaa    10440

tgaatttcaa gcaagaactt aatggaaata ccaagtcaaa acctactgtc tcttcctcca    10500

tggaatttaa gtatgatttc aattcttcaa tgctgtactc taccgctaaa ggagcagttg    10560

accacaagct tagcttggaa agcctcacct cttacttttc cattgagtca tctaccaaag    10620

gagatgtcaa gggttcggtt ctttctcggg aatattcagg aactattgct agtgaggcca    10680

acacttactt gaattccaag agcacacggt cttcagtgaa gctgcagggc acttccaaaa    10740

ttgatgatat ctggaacctt gaagtaaaag aaaattttgc tggagaagcc acactccaac    10800

gcatatattc cctctgggag cacagtacga aaaaccactt acagctagag ggcctctttt    10860

tcaccaacgg agaacataca agcaaagcca ccctggaact ctctccatgg caaatgtcag    10920

ctcttgttca ggtccatgca agtcagccca gttccttcca tgatttccct gaccttggcc    10980

aggaagtggc cctgaatgct aacactaaga accagaagat cagatggaaa aatgaagtcc    11040

ggattcattc tgggtctttc cagagccagg tcgagctttc caatgaccaa gaaaaggcac    11100

accttgacat tgcaggatcc ttagaaggac acctaaggtt cctcaaaaat atcatcctac    11160

cagtctatga caagagctta tgggatttcc taaagctgga tgtaaccacc agcattggta    11220

ggagacagca tcttcgtgtt tcaactgcct ttgtgtacac caaaaacccc aatggctatt    11280

cattctccat ccctgtaaaa gttttggctg ataaattcat tattcctggg ctgaaactaa    11340

atgatctaaa ttcagttctt gtcatgccta cgttccatgt cccatttaca gatcttcagg    11400

ttccatcgtg caaacttgac ttcagagaaa tacaaatcta taagaagctg agaacttcat    11460

catttgccct caacctacca acactccccg aggtaaaatt ccctgaagtt gatgtgttaa    11520

caaaatattc tcaaccagaa gactccttga ttcccttttt tgagataacc gtgcctgaat    11580

ctcagttaac tgtgtcccag ttcacgcttc caaaaagtgt ttcagatggc attgctgctt    11640

tggatctaaa tgcagtagcc aacaagatcg cagactttga gttgcccacc atcatcgtgc    11700

ctgagcagac cattgagatt ccctccatta agttctctgt acctgctgga attgtcattc    11760

cttcctttca agcactgact gcacgctttg aggtagactc tcccgtgtat aatgccactt    11820

ggagtgccag tttgaaaaac aaagcagatt atgttgaaac agtcctggat tccacatgca    11880

gctcaaccgt acagttccta gaatatgaac taaatgtttt gggaacacac aaaatcgaag    11940

atggtacgtt agcctctaag actaaaggaa catttgcaca ccgtgacttc agtgcagaat    12000

atgaagaaga tggcaaatat gaaggacttc aggaatggga aggaaaagcg cacctcaata    12060

tcaaaagccc agcgttcacc gatctccatc tgcgctacca gaaagacaag aaaggcatct    12120

ccacctcagc agcctcccca gccgtaggca ccgtgggcat ggatatggat gaagatgacg    12180

acttttctaa atggaacttc tactacagcc ctcagtcctc tccagataaa aaactcacca    12240

tattcaaaac tgagttgagg gtccgggaat ctgatgagga aactcagatc aaagttaatt    12300

gggaagaaga ggcagcttct ggcttgctaa cctctctgaa agacaacgtg cccaaggcca    12360

caggggtcct ttatgattat gtcaacaagt accactggga acacacaggg ctcaccctga    12420

gagaagtgtc ttcaaagctg agaagaaatc tgcagaacaa tgctgagtgg gtttatcaag    12480

gggccattag gcaaattgat gatatcgacg tgaggttcca gaaagcagcc agtggcacca    12540

ctgggaccta ccaagagtgg aaggacaagg cccagaatct gtaccaggaa ctgttgactc    12600

aggaaggcca agccagtttc cagggactca aggataacgt gtttgatggc ttggtacgag    12660

ttactcaaga attccatatg aaagtcaagc atctgattga ctcactcatt gattttctga    12720

acttccccag attccagttt ccggggaaac ctgggatata cactagggag gaactttgca    12780

ctatgttcat aagggaggta gggacggtac tgtcccaggt atattcgaaa gtccataatg    12840

gttcagaaat actgttttcc tatttccaag acctagtgat tacacttcct ttcgagttaa    12900

ggaaacataa actaatagat gtaatctcga tgtataggga actgttgaaa gatttatcaa    12960

aagaagccca agaggtattt aaagccattc agtctctcaa gaccacagag gtgctacgta    13020

atcttcagga ccttttacaa ttcattttcc aactaataga agataacatt aaacagctga    13080

aagagatgaa atttacttat cttattaatt atatccaaga tgagatcaac acaatcttca    13140

gtgattatat cccatatgtt tttaaattgt tgaaagaaaa cctatgcctt aatcttcata    13200

agttcaatga atttattcaa aacgagcttc aggaagcttc tcaagagtta cagcagatcc    13260

atcaatacat tatggccctt cgtgaagaat attttgatcc aagtatagtt ggctggacag    13320

tgaaatatta tgaacttgaa gaaaagatag tcagtctgat caagaacctg ttagttgctc    13380

ttaaggactt ccattctgaa tatattgtca gtgcctctaa ctttacttcc caactctcaa    13440

gtcaagttga gcaatttctg cacagaaata ttcaggaata tcttagcatc cttaccgatc    13500

cagatggaaa agggaaagag aagattgcag agctttctgc cactgctcag gaaataatta    13560

aaagccaggc cattgcgacg aagaaaataa tttctgatta ccaccagcag tttagatata    13620

aactgcaaga tttttcagac caactctctg attactatga aaaatttatt gctgaatcca    13680

aaagattgat tgacctgtcc attcaaaact accacacatt tctgatatac atcacggagt    13740

tactgaaaaa gctgcaatca accacagtca tgaaccccta catgaagctt gctccaggag    13800

aacttactat catcctctaa ttttttaaaa gaaatcttca tttattcttc ttttccaatt    13860

gaactttcac atagcacaga aaaaattcaa actgcctata ttgataaaac catacagtga    13920

gccagccttg cagtaggcag tagactataa gcagaagcac atatgaactg gacctgcacc    13980

aaagctggca ccagggctcg gaaggtctct gaactcagaa ggatggcatt ttttgcaagt    14040

taaagaaaat caggatctga gttattttgc taaacttggg ggaggaggaa caaataaatg    14100

gagtctttat tgtgtatcat a                                              14121


<210>  46
<211>  4563
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Leu Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Val 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Ala  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Leu  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


Asp Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Thr Thr Thr Lys  Ala Gln Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Ile Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Phe Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Tyr Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Glu Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Ser 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  47
<211>  2646
<212>  DNA
<213>  Homo sapiens

<400>  47
agataagcgg cctctaggcg ccgggccctc agtctctccc agcgaccgcc gcgggggcaa       60

ggcctggagc tgtggttcga atttgtgcag gcagcgggtg ctggctttta gggtccgccg      120

cctctctgcc taatgagctg caccagaatg atccaggttt tagatccacg tcctttgaca      180

agttcggtca tgcccgtgga tgtggccatg aggctttgct tggcacattc accacctgtg      240

aagagtttcc tgggcccgta cgatgaattt caacgacgac attttgtgaa taaattaaag      300

cccctgaaat catgtctcaa tataaaacac aaagccaaat cacagaatga ctggaagtgc      360

tcacacaacc aagccaagaa gcgcgttgtg tttgctgact ccaagggcct ctctctcact      420

gcgatccatg tcttctccga cctcccagaa gaaccagcgt gggatctgca gtttgatctc      480

ttggacctta atgatatctc ctctgcctta aaacaccacg aggagaaaaa cttgatttta      540

gatttccctc agccttcaac cgattactta agtttccgga gccactttca gaagaacttt      600

gtctgtctgg agaactgctc gttgcaagag cgaacagtga cagggactgt taaagtcaaa      660

aatgtgagtt ttgagaagaa agttcagatc cgtatcactt tcgattcttg gaaaaactac      720

actgacgtag actgtgtcta tatgaaaaat gtgtatggtg gcacagatag tgataccttc      780

tcatttgcca ttgacttacc ccctgtcatt ccaactgagc agaaaattga gttctgcatt      840

tcttaccatg ctaatgggca agtcttttgg gacaacaatg atggtcagaa ttatagaatt      900

gttcatgttc aatggaagcc tgatggggtg cagacacaga tggcacccca ggactgtgca      960

ttccaccaga cgtctcctaa gacagagtta gagtcaacaa tctttggcag tccgaggctg     1020

gctagtgggc tcttcccaga gtggcagagc tgggggagaa tggagaactt ggcctcttat     1080

cgatgaatta agcaacaatg taactggtct tgacttgtca tattccccca tgcaatccta     1140

ggtctgtatt gctcaatttt aggaagcctt tgctactcca tcagtaggtt tagatttgag     1200

cttttgagac ctggctatgg aaaagaaaga cacttgagaa tttagtgttg gggtctgtac     1260

agatgatgct acccaatttg gctttgaagg atcaagtaac aggttgaaaa ctatttttat     1320

aaaggtaata ctttttcagt tcccttcttc cttccctctc aatccactag ctttcatgtt     1380

gggcaaggaa aagttgagga aggatggctg atggtgatgg aaagctgtgt taatggtatg     1440

aggaatgtgt gaaaagtata cacaaagggc tctgaagctc aagtcagagg agtgggaggt     1500

ctgatcattg ttggtggaaa aacgtaaggt tattttgtgc ttttaagttg gttttacaat     1560

tctttcctgg ggaaattatt tctggagggg aaaaagatcc attctacgta tccttgtgga     1620

gaaaagctaa ataaccttta agaatgtggg tggtattgga gaaagaagat gaattatagc     1680

tccggagaat caagatctta agtgaagcct ttctgttcag atgtgatcta taaataatca     1740

taatttgggg aaagtttaag caaatctggc tttgtagtcc tgatgttata agtgactttg     1800

tgatcaaact gtcaggcttg ggttcttgtt atagaatgct tggtatagaa aaaccatgcc     1860

atcattaatg gctaacaaca cgtagggact tcatgtcatg tcaaagatag ctctttgcaa     1920

gtgccttgat taaaccagaa aactgtcatc gtttaaccca aatatctgaa tggtcatctg     1980

gtaactcatg ggtttttggc ctcataagat ggtccactct gtacacaggc attcctcctg     2040

caataatgtt gtatctttga gaccgttgtc agtgtacaca actcacatcc ttcatattga     2100

aggtgactca tttttctgca cacttttttg atgtgatgct tgacgtgagg cccgacacta     2160

ggattctcaa tgcaagaatc cagtaccttg cacatagaag tagcaaccca tcccttgcct     2220

attttcatct tgctgttttc ttttttttaa aaaaatggat gtgacttgtt ttgaatgttt     2280

tgtattatac ttgtttttgt gtgtgcataa attcattctg taggatctta agaaaaagag     2340

tcccagaatg ttgcttctat tattgtgcac aaccattgag aggtgttaca agaatgcagt     2400

taattttaac atgtgtgatg tgccatggtg gaaaagtact atcggaataa ctctgcagtg     2460

acagaatttg aagtttggct agcatccata cttttctact gtaaatattt cactctcctc     2520

tagctatcct tgatgagctt ctcactttaa gaataaatgt gtttgatata aaaaaaaaaa     2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2640

aaaaaa                                                                2646


<210>  48
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Cys Thr Arg Met Ile Gln Val Leu Asp Pro Arg Pro Leu Thr 
1               5                   10                  15      


Ser Ser Val Met Pro Val Asp Val Ala Met Arg Leu Cys Leu Ala His 
            20                  25                  30          


Ser Pro Pro Val Lys Ser Phe Leu Gly Pro Tyr Asp Glu Phe Gln Arg 
        35                  40                  45              


Arg His Phe Val Asn Lys Leu Lys Pro Leu Lys Ser Cys Leu Asn Ile 
    50                  55                  60                  


Lys His Lys Ala Lys Ser Gln Asn Asp Trp Lys Cys Ser His Asn Gln 
65                  70                  75                  80  


Ala Lys Lys Arg Val Val Phe Ala Asp Ser Lys Gly Leu Ser Leu Thr 
                85                  90                  95      


Ala Ile His Val Phe Ser Asp Leu Pro Glu Glu Pro Ala Trp Asp Leu 
            100                 105                 110         


Gln Phe Asp Leu Leu Asp Leu Asn Asp Ile Ser Ser Ala Leu Lys His 
        115                 120                 125             


His Glu Glu Lys Asn Leu Ile Leu Asp Phe Pro Gln Pro Ser Thr Asp 
    130                 135                 140                 


Tyr Leu Ser Phe Arg Ser His Phe Gln Lys Asn Phe Val Cys Leu Glu 
145                 150                 155                 160 


Asn Cys Ser Leu Gln Glu Arg Thr Val Thr Gly Thr Val Lys Val Lys 
                165                 170                 175     


Asn Val Ser Phe Glu Lys Lys Val Gln Ile Arg Ile Thr Phe Asp Ser 
            180                 185                 190         


Trp Lys Asn Tyr Thr Asp Val Asp Cys Val Tyr Met Lys Asn Val Tyr 
        195                 200                 205             


Gly Gly Thr Asp Ser Asp Thr Phe Ser Phe Ala Ile Asp Leu Pro Pro 
    210                 215                 220                 


Val Ile Pro Thr Glu Gln Lys Ile Glu Phe Cys Ile Ser Tyr His Ala 
225                 230                 235                 240 


Asn Gly Gln Val Phe Trp Asp Asn Asn Asp Gly Gln Asn Tyr Arg Ile 
                245                 250                 255     


Val His Val Gln Trp Lys Pro Asp Gly Val Gln Thr Gln Met Ala Pro 
            260                 265                 270         


Gln Asp Cys Ala Phe His Gln Thr Ser Pro Lys Thr Glu Leu Glu Ser 
        275                 280                 285             


Thr Ile Phe Gly Ser Pro Arg Leu Ala Ser Gly Leu Phe Pro Glu Trp 
    290                 295                 300                 


Gln Ser Trp Gly Arg Met Glu Asn Leu Ala Ser Tyr Arg 
305                 310                 315         


<210>  49
<211>  3052
<212>  DNA
<213>  Homo sapiens

<400>  49
caggaccatg gaactcagcg tcctcctctt ccttgcactc ctcacaggac tcttgctact       60

cctggttcag cgccacccta acacccatga ccgcctccca ccagggcccc gccctctgcc      120

ccttttggga aaccttctgc agatggatag aagaggccta ctcaaatcct ttctgaggtt      180

ccgagagaaa tatggggacg tcttcacggt acacctggga ccgaggcccg tggtcatgct      240

gtgtggagta gaggccatac gggaggccct tgtggacaag gctgaggcct tctctggccg      300

gggaaaaatc gccatggtcg acccattctt ccggggatat ggtgtgatct ttgccaatgg      360

aaaccgctgg aaggtgcttc ggcgattctc tgtgaccact atgagggact tcgggatggg      420

aaagcggagt gtggaggagc ggattcagga ggaggctcag tgtctgatag aggagcttcg      480

gaaatccaag ggggccctca tggaccccac cttcctcttc cagtccatta ccgccaacat      540

catctgctcc atcgtctttg gaaaacgatt ccactaccaa gatcaagagt tcctgaagat      600

gctgaacttg ttctaccaga ctttttcact catcagctct gtattcggcc agctgtttga      660

gctcttctct ggcttcttga aatactttcc tggggcacac aggcaagttt acaaaaacct      720

gcaggaaatc aatgcttaca ttggccacag tgtggagaag caccgtgaaa ccctggaccc      780

cagcgccccc aaggacctca tcgacaccta cctgctccac atggaaaaag agaaatccaa      840

cgcacacagt gaattcagcc accagaacct caacctcaac acgctctcgc tcttctttgc      900

tggcactgag accaccagca ccactctccg ctacggcttc ctgctcatgc tcaaataccc      960

tcatgttgca gagagagtct acagggagat tgaacaggtg attggcccac atcgccctcc     1020

agagcttcat gaccgagcca aaatgccata cacagaggca gtcatctatg agattcagag     1080

attttccgac cttctcccca tgggtgtgcc ccacattgtc acccaacaca ccagcttccg     1140

agggtacatc atccccaagg acacagaagt atttctcatc ctgagcactg ctctccatga     1200

cccacactac tttgaaaaac cagacgcctt caatcctgac cactttctgg atgccaatgg     1260

ggcactgaaa aagactgaag cttttatccc cttctcctta gggaagcgga tttgtcttgg     1320

tgaaggcatc gcccgtgcgg aattgttcct cttcttcacc accatcctcc agaacttctc     1380

catggccagc cccgtggccc cagaagacat cgatctgaca ccccaggagt gtggtgtggg     1440

caaaataccc ccaacatacc agatccgctt cctgccccgc tgaaggggct gagggaaggg     1500

ggtcaaagga ttccagggtc attcagtgtc cccgcctctg tagacaatgg ctctgactcc     1560

ccgcaacttc ctgcctctga gagacctgct acaagccagc ttccttcccc tccatggcac     1620

cagttgtctg aggtcacatt gcaagtgagt gcaggagtga gattatcgaa aattataata     1680

tacaaaatca tatatatata tatgttcttg ttttttgaga cagagtctca cactgttgcc     1740

caggctggag tgcagtggcg tgatctcggc tcactgcaac ctccaccccc ggggatcaag     1800

caactctcct gcctcagcct ccctagtagc tgggattaca ggcatgcact accacgcttg     1860

gctaattttt gtatttttag tagagatggg gtttcactgt gtaggccagg ctggtctcga     1920

actcctgaac tcaagtgatt cacccacctt agcctcccaa agtgctggga ttacaggcgt     1980

gagtcaccgt gcccagccat gtatatatat aattttaaaa attaagctga aattcacata     2040

acataaaatt agctgtttta aagtgtaaaa tttagtggcg tgtggttcat tcacaaagct     2100

gtacaaccac caccatctag ttccaaacat tttctttttt tctgagatgg agtctcactc     2160

tgtcacccag gttcgagttc agtggtgcca tctctgtcca ctgcaacctc cacatcctgg     2220

gttcaagtga ttctcctgcc tcagcctctg gaggagctgg tatcacaggc gtcccccacc     2280

acgcctggct aaattttgta tttttaggtg gtcttgaact cctgatgtca ggtgattctc     2340

ctagctccaa atgttttcat tatctctccc ccaacaaaac ccatacctat caagctgtca     2400

ctccccatac cccattctct ttttcatctc ggcccctgtc aatctggttt ttgtcactat     2460

ggacttacca attctgaata tttcccataa acagaatcat acaatatttg attttttttt     2520

tttttttgaa actaagcctt gctctgtctc ccaggctgga gtgctatggt gcaatttttg     2580

ttcactgcaa cctctgcctt ccaagatcaa gagattctcc agtctcagct cccaagtagc     2640

tgggattaca ggcatgtact accatgcctg gctaattttc ttgtagtttt agtagggaca     2700

tgttggccag gctggtggtg agctcctggc ctcaggtgat ccacccacct cagtgttcca     2760

aagtgctgat attacaggca taatatgtga tcttttgtgt ctggttgctt tcatgttgaa     2820

tgctattttt gaggttcatg cctgttgtag accacagtca cacactgctg tagtcttccc     2880

cagtcctcat tcccagctgc ctcttcctac tgcttccgtc tatcaaaaag cccccttggc     2940

ccaggttccc tgagctgtgg gattctgcac tggtgctttg gattccctga tatgttcctt     3000

caaatctgct gagaattaaa taaacatctc taaagcctga cctccccacg tc             3052


<210>  50
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


<210>  51
<211>  526
<212>  DNA
<213>  Homo sapiens

<400>  51
cagctacagc acagatcagc accatgaagc ttctcacggg cctggttttc tgctccttgg       60

tcctgagtgt cagcagccga agcttctttt cgttccttgg cgaggctttt gatggggctc      120

gggacatgtg gagagcctac tctgacatga gagaagccaa ttacatcggc tcagacaaat      180

acttccatgc tcgggggaac tatgatgctg ccaaaagggg acctgggggt gcctgggccg      240

cagaagtgat cagcaatgcc agagagaata tccagagact cacaggccat ggtgcggagg      300

actcgctggc cgatcaggct gccaataaat ggggcaggag tggcagagac cccaatcact      360

tccgacctgc tggcctgcct gagaaatact gagcttcctc ttcactctgc tctcaggaga      420

cctggctatg agccctcggg gcagggattc aaagttagtg aggtctatgt ccagagaagc      480

tgagatatgg catataatag gcatctaata aatgcttaag aggtgg                     526


<210>  52
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  53
<211>  716
<212>  DNA
<213>  Homo sapiens

<400>  53
aggctcagta taaatagcag ccaccgctcc ctggcaggca gggacccgca gctcagctac       60

agcacagatc aggtgaggag cacaccaagg agtgattttt aaaacttact ctgttttctc      120

tttcccaaca agattatcat ttcctttaaa aaaaatagtt atcctggggc atacagccat      180

accattctga aggtgtctta tctcctctga tctagagagc accatgaagc ttctcacggg      240

cctggttttc tgctccttgg tcctgggtgt cagcagccga agcttctttt cgttccttgg      300

cgaggctttt gatggggctc gggacatgtg gagagcctac tctgacatga gagaagccaa      360

ttacatcggc tcagacaaat acttccatgc tcgggggaac tatgatgctg ccaaaagggg      420

acctgggggt gcctgggctg cagaagtgat cagcgatgcc agagagaata tccagagatt      480

ctttggccat ggtgcggagg actcgctggc tgatcaggct gccaatgaat ggggcaggag      540

tggcaaagac cccaatcact tccgacctgc tggcctgcct gagaaatact gagcttcctc      600

ttcactctgc tctcaggaga tctggctgtg aggccctcag ggcagggata caaagcgggg      660

agagggtaca caatgggtat ctaataaata cttaagaggt ggaatttgtg gaaact          716


<210>  54
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  55
<211>  3951
<212>  DNA
<213>  Homo sapiens

<400>  55
gaaggtgcaa gagctgtctg aaaaggtcag agcaaagcat gaagctggtg agcagctgtg       60

accatagctg gaagcttctc tctgagcttt ctcctggtta cctcctcctc ccctacgtga      120

ccagtcagcc aagtgttaag tccaggggaa cattttgctg cttccaagta ctgtctcact      180

agtgttattt gccataactt gcggccacag ggcaaggtcc aggtgctcag acctttacat      240

cctggacttt ccaaggcctc ccaaagctct ctggcaccca gggaacagtg tgcgtgtcga      300

gagcttaatc cgcaggagca tagccatggt tctctggggt ccagtgctgg gagctctgct      360

ggtggtcatt gctggatacc tgtgcctgcc agggatgctc cgacaacgca ggccatggga      420

gccccctctg gacaagggta ccgtgccctg gcttggccat gccatggctt tccggaagaa      480

tatgtttgaa tttctgaagc gcatgaggac caagcatggg gatgtgttca cagtgcagct      540

agggggccag tacttcacct tcgtcatgga ccccctctcc tttggcccca tcctcaagga      600

cacacagaga aaactagact ttgggcaata tgcaaaaaaa ctggtgctga aggtatttgg      660

ataccgttca gtgcaagggg accatgagat gatacactca gccagcacca agcatctgag      720

gggggatggc ttgaaggatc ttaatgagac catgctggac agcctgtcct ttgtaatgct      780

gacgtccaaa ggctggagtc tggatgccag ttgctggcat gaggacagcc tctttcgctt      840

ctgctattac atcttgttca cagctggcta cctgagcttg ttcggctaca cgaaggacaa      900

ggagcaggac ctgctacagg caggagagtt attcatggag ttccgcaagt ttgaccttct      960

tttcccaagg tttgtctact ccctgctgtg gccccgggag tggctagaag tgggccgact     1020

ccagcgtctc tttcacaaga tgctctccgt gagccacagc caggagaagg agggcatcag     1080

caactggctg ggcaacatgc ttcagtttct gagggagcag ggggtaccct cagctatgca     1140

ggacaagttc aacttcatga tgctctgggc ctcccagggg aacacggggc ctacctcttt     1200

ctgggccctc ttgtacctcc tgaagcaccc agaagctatt cgggctgtga gggaggaagc     1260

tacccaggtc ctgggtgagg ccaggctgga gaccaagcag tcctttgcct tcaaactcgg     1320

tgccctgcaa cacaccccag ttctagacag cgtggtggag gagacgctgc ggctgagggc     1380

tgcacccacc ctcctcaggt tggttcatga agactatacc ctgaagatgt ccagtgggca     1440

ggagtatctg ttccgccatg gagacatcct ggccctcttt ccctacctct cagtgcacat     1500

ggaccctgac atccaccctg agcccaccgt cttcaagtac gatcgcttcc tcaaccctaa     1560

tggcagccgg aaagtggact tcttcaagac aggcaagaag atccaccact acaccatgcc     1620

ctggggttcg ggcgtttcca tctgccctgg gaggttcttt gcactcagtg aggtgaagct     1680

ctttatcctg cttatggtca cacactttga cttagagttg gtggaccctg acacaccact     1740

accccatgtt gacccgcagc gctggggttt tggcaccatg cagcccagcc acgatgtgcg     1800

cttccgctac cgcctgcatc ctacagagtg agcttggcca agccagctgc aaacctggcc     1860

agaggagttc tattgcatct ctcacctgtt ctcacccctc tgcagcccca agaccccact     1920

ggccacccct ccctctggtc ctgtggcacc ccctacctct gttctgcctg tcctcgctct     1980

ctccccgcct agtcatctga caggcttatc attctcttta aaataccatc tctcagagtg     2040

ggttctgccg aaccctcctc tcacaggaag tccagaggaa gggggagtat ctgtgggcaa     2100

cttggtttgg gagatgatgc ctgccttgag aagtcctgag tacagagact ggttcccccc     2160

agacacgagt aacatggcat cttgcaaaca tcagcctcca ctctcccagc ttgctttagt     2220

tttttcagca acacttatcc cacatcctat ggaattcagg ttctagaaca gtgtcatcca     2280

acataaatat gaagcaagct acatgagtag tggggttttt tggttttgtt tgtttgtttt     2340

gagacagagt cttgctctgt cgccgaggct gcagtgcagc ggtgcgatct ctgctcactg     2400

caacctctgc ctcctgggtt taagcaattc tcctgcctca gcctccccag tagctgggat     2460

tacaggcacc taccaccttg cccagctaat ttagtttcct ggtaaacaca tttttaaaaa     2520

gtaaaatgaa acaattcatt tttataatat actttactta atccaatata tccaaaatat     2580

tggcatttca acgtgatcac tattaaaaat tttaacgtaa tagtttttac cttccctttt     2640

tcatcctgtc ttcaaagtct ggtatgtact gtacttttgc agttcttccc agttcagact     2700

agccacattc caagtgctta attgccgtgt gtggcaggtg gctgccctat tggatacaac     2760

aggtctagag aaatgatacc tttttttttt ttttgagaca gagtctcact ctgttgccca     2820

ggctgcagtg cagtggtgtg atcttggctc actacaacct ctgcctcccg ggttcaagta     2880

attctcctgc ctcaggcttc tgagtagctg ggattatagg tgcgcaccac cacacccggc     2940

tagtttctgt atttttagta gagacggcgt ttcaccattt tggccggcct cctcggcctc     3000

ccaaagttct gggattacag gcatgagcca ctgtgcccag tcaggatgtc tttaatgtag     3060

gaatcattca agatccctcc tcagtgccca tgtctccccc acctcagggt gctgtcaacc     3120

ctcccttggt ttccatgatc attgctgaac tcagagcttt cttctatccc cagacccaca     3180

tgggagtctc ccagcacctc tgactcagct tggccaatgc agaacttggc atctgaaccc     3240

ctgcctcttc cctgaaccac tcctcctcct gatttccctg ctctctctgc tcagaacact     3300

accattcacc ccatctccca gagacactct ccctcctcct ctttcacctt catacaagca     3360

ggcccccgtc ctatcagtac acccccctgt gatgcctctg aaatatgtac cctcctcccc     3420

tctcctactg tcattcttat acctgtgatc tctgcgtttc tcttctacac tgctgccaga     3480

ggcctttttg ccaaaagcac tgctgattgt cactctttta ctttcctggt tcccctttga     3540

cttcacacac ttgacgttta cattttgtca cagttggtcc cccttgcctt cacatacctg     3600

atgtttaaat tttgtcacgg ttggtctcca aacttctcaa ctttgccagc tttctccaat     3660

gaaaccatca gtagagacat tgctgttcct gcccatccca gtgccagcta ctccttcctg     3720

gaagccttcc tggatttcac gcatcccatc ctctggccag aaatggcctc cgaactgtgc     3780

agctcctgcg gcaccatttg tatcatagca tatctgttat gtgtcgttgc tttctgtgtc     3840

ttggtttctg cctgctgccc acttccctag actggagcct actggggcat ggtattttat     3900

tcatttctga cctccaattc cctaagtgga gattaaatgt tagaaacctg a              3951


<210>  56
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Pro Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  57
<211>  6894
<212>  DNA
<213>  Homo sapiens

<400>  57
tgacccggtc cgtgtgggcc agcgggaagg aagccagttg agggaagttc tccatgaatg       60

tacgtcacaa tgatgatgac cgaccaaatc cctctggaac tgccaccatt gctgaacgga      120

gaggtagcca tgatgcccca cttggtgaat ggagatgcag ctcagcaggt tattctcgtt      180

caagttaatc caggtgagac tttcacaata agagcagagg atggaacact tcagtgcatt      240

caaggacctg ctgaagttcc catgatgtca cccaatggat ccattcctcc cattcatgtg      300

cctccaggtt atatctcaca ggtgattgaa gatagtactg gagtccgccg ggtggtggtc      360

acaccccagt ctcctgagtg ttatccccca agctacccct cagccatgtc tccaacccat      420

catctccctc cctatctgac tcaccatcca cattttattc ataactcaca cacggcttac      480

tacccacctg ttaccggacc tggagatatg ccgcctcagt tttttcccca gcatcatctt      540

ccccacacaa tatatggtga gcaagaaatt ataccatttt atggaatgtc aagctacatc      600

acccgagaag accagtacag caagcctccg cacaaaaaac tgaaagaccg ccagatcgat      660

cgccagaacc gactcaacag acctccttct gctatctaca aaagcagctg cacaacagta      720

tacaatggct atgggaaggg ccatagtggt ggaagtggcg gaggcggcag cggtagtggt      780

cccggaatta agaaaacaga gcgacgagca agaagcagcc caaagtcgaa tgattcagac      840

ttgcaagaat atgagttgga agtaaagagg gtgcaagaca ttctttcggg aatagagaaa      900

ccacaggttt ctaatattca ggcaagagca gttgtgttgt cctgggctcc ccctgttgga      960

ctttcctgtg gaccccacag tggtctttcc ttcccctaca gttacgaggt ggccttatca     1020

gacaaaggac gagatggaaa atacaagata atttacagtg gagaagaatt agaatgtaac     1080

ctgaaagatc ttagaccagc aacagattat catgtgaggg tgtatgccat gtacaattcc     1140

gtaaagggat cctgctccga gcctgttagc ttcaccaccc acagctgtgc acccgagtgt     1200

cctttccccc ctaagctggc acataggagc aaaagttcac taaccctgca gtggaaggca     1260

ccaattgaca acggttcaaa aatcaccaac taccttttag agtgggatga gggaaaaaga     1320

aatagtggtt tcagacagtg cttcttcggg agccagaagc actgcaagtt gacaaagctt     1380

tgtccggcaa tggggtacac attcaggctg gccgctcgaa acgacattgg taccagtggt     1440

tatagccaag aggtggtgtg ctacacatta ggaaatatcc ctcagatgcc ttctgcacca     1500

aggctggttc gagctggcat cacatgggtc acgttgcagt ggagtaagcc agaaggctgt     1560

tcacccgagg aagtgatcac ctacaccttg gaaattcagg aggatgaaaa tgataacctt     1620

ttccacccaa aatacactgg agaggattta acctgtactg tgaaaaatct caaaagaagc     1680

acacagtata cattcaggct gactgcttct aatacggaag gaaaaagctg tccaagcgaa     1740

gttcttgttt gtacgacgag tcctgacagg cctggacctc ctaccagacc gcttgtcaaa     1800

ggcccagtta catctcatgg ctttagtgtc aaatgggatc cccctaagga caatggtggt     1860

tcagaaatcc tcaagtactt gctagagatt actgatggaa attctgaagc gaatcagtgg     1920

gaagtggcct acagtgggtc ggctaccgaa tacaccttca cccacttgaa accaggcact     1980

ttgtacaaac tccgagcatg ctgcatcagt accggcggac acagccagtg ttctgaaagt     2040

ctccctgttc gcacactaag cattgcacca ggtcaatgtc gaccaccgag ggttttgggt     2100

agaccaaagc acaaagaagt ccacttagag tgggatgttc ctgcatcgga aagtggctgt     2160

gaggtctcag agtacagcgt ggagatgacg gagcccgaag acgtagcctc ggaagtgtac     2220

catggcccag agctggagtg caccgtcggc aacctgcttc ctggaaccgt gtatcgcttc     2280

cgggtgaggg ctctgaatga tggagggtat ggtccctatt ctgatgtctc agaaattacc     2340

actgctgcag ggcctcctgg acaatgcaaa gcaccttgta tttcttgtac acctgatgga     2400

tgtgtcttag tgggttggga gagtcctgat agttctggtg ctgacatctc agagtacagg     2460

ttggaatggg gagaagatga agaatcctta gaactcattt atcatgggac agacacccgt     2520

tttgaaataa gagacctgtt gcctgctgca cagtattgct gtagactaca ggccttcaat     2580

caagcagggg cagggccgta cagtgaactt gtcctttgcc agacgccagc gtctgcccct     2640

gaccccgtct ccactctctg tgtcctggag gaggagcccc ttgatgccta ccctgattca     2700

ccttctgcgt gccttgtact gaactgggaa gagccgtgca ataacggatc tgaaatcctt     2760

gcttacacca ttgatctagg agacactagc attaccgtgg gcaacaccac catgcatgtt     2820

atgaaagatc tccttccaga aaccacctac cggatcagaa ttcaggctat aaatgaaatt     2880

ggagctggac catttagtca gttcattaaa gcaaaaactc ggccattacc acccttgcct     2940

cctaggctag aatgtgctgc tgctggtcct cagagcctga agctaaaatg gggagacagt     3000

aactccaaga cacatgctgc tgaggacatt gtgtacacac tacagctgga ggacagaaac     3060

aagaggttta tttcaatcta cagaggaccc agccacacct acaaggtcca gagactgacg     3120

gaattcacat gctactcctt cagaatccag gcagcaagcg aggctggaga agggcccttc     3180

tcagaaacct ataccttcag cacaaccaaa agtgtccccc ccaccatcaa agcacctcga     3240

gtaacacagt tagaaggaaa ttcatgtgaa attttatggg agacggtacc atcaatgaaa     3300

ggtgaccctg ttaactacat tctgcaggta ttggttggaa gagaatctga gtacaaacag     3360

gtgtacaagg gagaagaagc cacattccaa atctcaggcc tccagaccaa cacagactac     3420

aggttccgcg tatgtgcgtg tcgtcgctgt ttagacacct ctcaggagct aagcggagcc     3480

ttcagcccct ctgcggcttt tgtattacaa cgaagtgagg tcatgcttac aggggacatg     3540

gggagcttag atgatcccaa aatgaagagc atgatgccta ctgatgaaca gtttgcagcc     3600

atcattgtgc ttggctttgc aactttgtcc attttatttg cctttatatt acagtacttc     3660

ttaatgaagt aaacccaaca aaactagagg tatgaattaa tgctacacat tttaatacac     3720

acatttattc agatactccc ctttttaaag cccttttgtt ttttgattta tatactctgt     3780

tttacagatt tagctagaaa aaaaatgtca gtgttttggt gcaccttttt gaaatgcaaa     3840

actaggaaaa ggttaaactg gatttttttt tttaaaaaaa agaaaaaaaa agaagaaaag     3900

tataccagat accaaaagct agctttctta tgttttcctt taaattttca gatttacctt     3960

cattctgttt tcactgatgt cttttgcaag cctttgattt tttttttttt gttacagttt     4020

agtaatttat attcaccagt cacttcatat gtcttgaaca tctgtatctg taaacatgaa     4080

tcaccgtgtg tgtacttaca gggctaggat ttcagtgttg tcagagtatt accacacagc     4140

aacagcaaca tacagaagat atgttcactc agataagact gccctaaaca accattttgt     4200

cactcagtta tttaactgtg tttagctcat ttaaatcaaa atgtgtactt taatctaaaa     4260

tgttttaata atctgtattt cttataattt taacactatg agctgcctgt ataagaaatc     4320

aagtaaccag aatgcaccta taaattatgg agcattgtag attttaccac atcaattcat     4380

agcagtaact ttaagagggc attgtgcaat agttagttgt tttcttgttc agctatttta     4440

aaggctgctt taacttgttt gtttgtcttt gtatataact acttctaatc taatcactag     4500

agttattata ttctgttatg tttgaccaga attatatgac aagaactggt gacagtttag     4560

tgcctctgcc cattgtccat gatttacact aattgtgagc agtcttctta tgtgtcagct     4620

cattattttt gaaacatttg cctttaggct gttctttgag gtatcaatga agtgattgaa     4680

tttcaatacc ttaattcagt gcacataata ctaatgtaac agcagatgaa aattgataaa     4740

acccaaaaga gagtcatcta aatttgtagt tcctatttct gtgggtttgc ctggccatgg     4800

ttggagaggg aatggtgttt gatggtaaac acagggtgtt tggggatcaa ggagcctaga     4860

ttctctccct ggatctgtca ctaacttgct gcgtgacctg aacacgtcac tttacctctc     4920

tgtgcctcag ttttcccatg catgaaaaat aaaataaaat aaaacgggga ttctaatgtt     4980

tgtaagtgct ttgagatctt tgaccaacag gtgctattgg agtgcaaagt gttactctta     5040

cgtgtttatt ttgagtcatg agataatcaa ttttaaccca aagtcattgg attatttata     5100

tgaagtccat aatgttcgag tacctcaggg acatttaaga gttggaggtg caaatatatt     5160

ccaaaagggt gcaacagaca cagtgtatcc ccctgcttct gtttttgtat atttttgcta     5220

cttggttttt cttgatcata gctattttgt gcttgatctt tattgtctaa gatgcagtat     5280

cctgtactag cttataatat tcccatacca aagtcatggg gaaacaaaca ttattttgtt     5340

tttggtttat ttatactata ttctgcatac agtactttaa atgccaatta cagtgcaatc     5400

tttatttatt gtaaaatttt ttaagtgtac ttatgtacta attttccctt gtagcatgtt     5460

atatttttgt gttttatact tttgtaattt taggtcagtc ttgttccttg gcaacatctg     5520

tagtattatt aatcttctga cattttctta tgtttttaaa aagataagag catctagtgc     5580

attaaatgcc aaaaaaaaaa tacattatca gtgattgaaa cgtttacatg tacccaaaaa     5640

ccataatcat ctcttggaag aaaatgctga gatcaatgaa ttattctgtg tgcctatatt     5700

gacgtagtga gtactagaga gttctgtatt ttattattga ctataataat tagtttaatt     5760

agctttgcaa actgatggca tcaaggtaaa tatatttttg ccaaagttct ggccttccaa     5820

aactcacccc cttatttaaa tgtgtgctat gacccactat gaccacagca tctgcatttt     5880

ctaaaaaatt ccatgcaggt gttttgggga gaggtatttt ttaagcaatg aaaattcaac     5940

tgagtacaaa gccccctctt ggggggttgg ggaagtctct tttttgaaac acttcagaac     6000

tgctgctata aagaaattct ctaattggtt gaattttttt tttaagtaaa tagtacttta     6060

ggccaaaatt tatatgaata tttgatcttc ttgagatttt catactatca tttaaccacc     6120

aggaagctga agtgtgtgaa gtacaaagct gacagcactt tattttattg ctctccatta     6180

tttggtattc attatattcc ttcagtcaga aaattattac tctctatggc actgtttttt     6240

atcacaaata tgtatatgtg atattgatat ataactatat atattgccat cacacacgaa     6300

caataaaata aagtgttcta ttaacctgat ctctttgccc ttttgctatg tgaggagtga     6360

atgagtggcc ttctgatgct ctgactcttc tctgtatgtc aaactcatcc ctggcacaag     6420

aaattccagt catgtgaagc aaactgccct ttgtcctcaa agaaattgtt gaaaaagaaa     6480

actttttaaa gagatttttt gcatattctc tgccttgttc ttatcaactt gaaatgttgg     6540

cattttctaa ccttgttttg ttggctacaa taattcagta ttcatgtcaa aattgagaag     6600

tgccctaatt gaatgtgttt gaatgttatc cttgcacaat tctttaaatt gaaagataaa     6660

atgttttacc tcactgttgg acatacattc caagcttttc aactctagga gaaaaagaaa     6720

atcatgtttt cctgtattgt aaattttaga ctatttcata tacattgtat taaaactgcc     6780

atatcaattt taatgtatag attttgcaaa tattatgcta tatgtaatac ctaactgtat     6840

ctgtagtgta tatgtaatat atttatgccc aataaatgtt ttaattcttt ctga           6894


<210>  58
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Ser Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Arg 
        195                 200                 205             


Pro Pro Ser Ala Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Thr Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  59
<211>  3779
<212>  DNA
<213>  Homo sapiens

<400>  59
ttctattgaa agggaaatgg gagaacaata tgtgttccta tggctcagtc cctataagat       60

tctgtactat tcagagttga ttttaagtgt cacttaactg aaattatcca acaaaccttc      120

atggcatgaa acattaacac agctcttttt atatggcatg gttcctatgg ctcaatccct      180

ataagattct gtactagttc agagttgatt ttaaaagtca cttaactgaa attatccaac      240

aaaccctcga ggacattaaa cattaacgtg gctcttttta tatggcatgg ttcattatca      300

tgccaataaa tgattaatcg taactctctg tcttgaccaa taattttgct ggacttttgt      360

gattcacaac gtgctctgtg ttgtaatgct acctcttgaa actgacatcc tagctttatt      420

gttttttatt acttccctaa ggtggctttc aaaagagaca ccaagtgaca tatttttagg      480

aggggtttaa aagtttgatg gggtagaagt aaacgttgct taactcaacc agcagcagag      540

ccagggccca gggaccagcg cttctgtgga cttggccttt ccagcagcag acccagcaat      600

gaatgatccg aacagctgtg tggacaatgc aacagtttgc tctggtgcat cctgtgtggt      660

acctgagagc aatttcaata acatcctaag tgtggtccta agtacggtgc tgaccatcct      720

gttggccttg gtgatgttct ccatgggatg caacgtggaa atcaagaaat ttctagggca      780

cataaagcgg ccgtggggca tttgtgttgg cttcctctgt cagtttggaa tcatgcccct      840

cacaggattc atcctgtcgg tggcctttga catcctcccg ctccaggccg tagtggtgct      900

cattatagga tgctgccctg gaggaactgc ctccaatatc ttggcctatt gggtcgatgg      960

cgacatggac ctgagcgtca gcatgaccac atgctccaca ctgcttgccc tcggaatgat     1020

gccgctgtgc ctccttatct ataccaaaat gtgggtcgac tctgggagca tcgtaattcc     1080

ctatgataac ataggtacat ctctggttgc tctcgttgtt cctgtttcca ttggaatgtt     1140

tgttaatcac aaatggcccc aaaaagcaaa gatcatactt aaaattgggt ccatcgcggg     1200

cgccatcctc attgtgctca tagctgtggt tggaggaata ttgtaccaaa gcgcctggat     1260

cattgctccc aaactgtgga ttataggaac aatatttcct gtggcgggtt actccctggg     1320

gtttcttctg gctagaattg ctggtctacc ctggtacagg tgccgaacgg ttgcttttga     1380

aacggggatg cagaacacgc agctatgttc caccatcgtt cagctctcct tcactcctga     1440

ggagctcaat gtcgtattca ccttcccgct catctacagc attttccagc tcgcctttgc     1500

cgcaatattc ttaggatttt atgtggcata caagaaatgt catggaaaaa acaaggcaga     1560

aattccagag agcaaagaaa atggaacgga gccagagtca tcgttttata aggcaaatgg     1620

aggatttcaa cctgacgaaa agtagacatc aagtggacaa aacagacgag ttccaaatta     1680

cgttcttaaa ccgtaactat atttaattat ttgttttggt aggacagttg gcagaaaaga     1740

gttaaagtga aaattggaat ttcattggaa ttcatgtatt ggtttcagta ccaagtgact     1800

ggtggcccaa ttctttaatg ggacaaatat tgtttcctat atatatgtat atgttttata     1860

tatgtatgta tactcatata gatatattgt cattgaaata ttcccccaaa atattctcag     1920

actaaacctg acatagggaa caccgagaat gaaaacatcg ttaacaccaa aactgaattc     1980

ttatgcagaa tttcctagcc catagatgac aacctgagtt tctgtatgtt aaagtagatg     2040

taatgaatta ttattattac agtggtcacg attttcttca gtgtttatga ttataaaaat     2100

tgacatgaac atctttcact gacattttaa tcattatttt aaaagctttg caacctatat     2160

atttatataa ctttgtaata taacatgggc aaatatctga cttcagtatt tttaaaaagt     2220

tgccttctcc agtggcagtc caaaagcaga aatgagagga aattattaca aaatagaatt     2280

caataaccat attggatgca ggctcttaac tcagcaggga tatcgtacat ctattgctct     2340

acctcagggg tccagtgata cccactagat cttccaagga aaaacataat tctttcaaac     2400

ggtgtgtatt tggcaaagag ctcttcaaat ctgggagagg gacttcctca aggttttcct     2460

gtgtgcagtg gatccacata gctaatatga cagctagtca gttgacaggg accacccaca     2520

gtaagcacca tggtcaggga ggtggcagga ggtgcaaaga cagaagtatt gagagaaaca     2580

ccaagactct agtggaggaa ttaattcaat gggagatagt ataaaataca tagaaaacac     2640

aagtaacaga aacctggttg aaatgcttaa ctagagtcaa ttagatgtgc aggagtaagt     2700

agtataagaa gaatcaagtc cgagagtgat caggaaatga gtattaaaca gtatttgaaa     2760

cagagaacgt gtcccagggc ccaaaagtca gaagggcccc accagccagg aaagttgttt     2820

caatgctgta agtaggtgta gccaagggaa gccaggacta tctgatatac ggtagcaggg     2880

gtttacggct gccaggggaa aataactcat caagtgttgg actttcaatt ataagatcga     2940

atttaatttc ctttccctca ttctgcagca atcagaatac acaatcttaa ccactcggtc     3000

cttagtggtt ttgttccatt ttgcattggg tattttcact gcctcataga gtctatttca     3060

agtgtttggc tgaaagggct ttttgcattt gcatgttctg agttcagatt ctgctggtgc     3120

acccaagcat tatgggaaca ggaactcaac ttagctcttc cagtagaggg gtgagggatt     3180

ctgcttttca aattcataac attgatcttt ttatgcaaga tttccattta cagttgaata     3240

agtacttcat atttttccat cattagacaa atacaaaatg gactaaataa ttttaagaga     3300

tagtggaggc agcagggggt acagacttcc ttcttagaga gtgtcagaga atatgctccc     3360

aatggtggaa aggaagattt acagtctagc ggctaagtac ctcctacaca tttcccatca     3420

atcagaaaat agacaggtac actaaaggga cctgagaact cctcttgtaa tttcaacaca     3480

cccaaaatca agggcctgga tgccagcagc tgcagcaagc aggtttttcc tccctgttga     3540

gcaagacagg tgaggcaaga taggacttgg ctttcttaca tgatgcggta acttgtgact     3600

tgagtctttt tccctaattt gctagtggga agaaaaatag ctgagctttc taaaatgata     3660

gctctctatt tttaaatgaa tttgaaaagt cgattaaatt atgtatttta ttgcctctga     3720

gtatcatatt aaatgaatat tttattttaa aggcttaaat aaatgaaaat gatttttgt      3779


<210>  60
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  60

Met Asn Asp Pro Asn Ser Cys Val Asp Asn Ala Thr Val Cys Ser Gly 
1               5                   10                  15      


Ala Ser Cys Val Val Pro Glu Ser Asn Phe Asn Asn Ile Leu Ser Val 
            20                  25                  30          


Val Leu Ser Thr Val Leu Thr Ile Leu Leu Ala Leu Val Met Phe Ser 
        35                  40                  45              


Met Gly Cys Asn Val Glu Ile Lys Lys Phe Leu Gly His Ile Lys Arg 
    50                  55                  60                  


Pro Trp Gly Ile Cys Val Gly Phe Leu Cys Gln Phe Gly Ile Met Pro 
65                  70                  75                  80  


Leu Thr Gly Phe Ile Leu Ser Val Ala Phe Asp Ile Leu Pro Leu Gln 
                85                  90                  95      


Ala Val Val Val Leu Ile Ile Gly Cys Cys Pro Gly Gly Thr Ala Ser 
            100                 105                 110         


Asn Ile Leu Ala Tyr Trp Val Asp Gly Asp Met Asp Leu Ser Val Ser 
        115                 120                 125             


Met Thr Thr Cys Ser Thr Leu Leu Ala Leu Gly Met Met Pro Leu Cys 
    130                 135                 140                 


Leu Leu Ile Tyr Thr Lys Met Trp Val Asp Ser Gly Ser Ile Val Ile 
145                 150                 155                 160 


Pro Tyr Asp Asn Ile Gly Thr Ser Leu Val Ala Leu Val Val Pro Val 
                165                 170                 175     


Ser Ile Gly Met Phe Val Asn His Lys Trp Pro Gln Lys Ala Lys Ile 
            180                 185                 190         


Ile Leu Lys Ile Gly Ser Ile Ala Gly Ala Ile Leu Ile Val Leu Ile 
        195                 200                 205             


Ala Val Val Gly Gly Ile Leu Tyr Gln Ser Ala Trp Ile Ile Ala Pro 
    210                 215                 220                 


Lys Leu Trp Ile Ile Gly Thr Ile Phe Pro Val Ala Gly Tyr Ser Leu 
225                 230                 235                 240 


Gly Phe Leu Leu Ala Arg Ile Ala Gly Leu Pro Trp Tyr Arg Cys Arg 
                245                 250                 255     


Thr Val Ala Phe Glu Thr Gly Met Gln Asn Thr Gln Leu Cys Ser Thr 
            260                 265                 270         


Ile Val Gln Leu Ser Phe Thr Pro Glu Glu Leu Asn Val Val Phe Thr 
        275                 280                 285             


Phe Pro Leu Ile Tyr Ser Ile Phe Gln Leu Ala Phe Ala Ala Ile Phe 
    290                 295                 300                 


Leu Gly Phe Tyr Val Ala Tyr Lys Lys Cys His Gly Lys Asn Lys Ala 
305                 310                 315                 320 


Glu Ile Pro Glu Ser Lys Glu Asn Gly Thr Glu Pro Glu Ser Ser Phe 
                325                 330                 335     


Tyr Lys Ala Asn Gly Gly Phe Gln Pro Asp Glu Lys 
            340                 345             


<210>  61
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  61
agtcccagcg aacccgcgtg caacctgtcc cgactctagc cgcctcttca gcacgccatg       60

gatcccaact gctcctgcgc cgccggtgac tcctgcacct gcgccggttc ctgcaaatgc      120

aaagagtgca aatgcacttc gtgcaagaaa agctgctgct cctgctgccc tgtgggctgt      180

gccaagtgtg cccaaggctg catctgcaaa ggggcgtcgg acaagtgcag ctgctgcgcc      240

tgatgctggg acagccccgc tcccagatgt aaagaacgcg acttccacaa acctggattt      300

tttatgtaca accctgaccg tgaccgtttg ctatattcct ttttctatga aataatgtga      360

atgataataa aa                                                          372


<210>  62
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Asp Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210>  63
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  63
aagtttttct cttcagtgac agacacagac atagaacatt cacgatgtac ttgggactga       60

actatgtatt catagttttt ctcttaaatg gtgtccagag tgaagtgaag cttgaggagt      120

ctggaggagg cttggtgcaa cctggaggat ccatgaaact ctcttgtgct gcctctggat      180

tcacttttag tgacgcctgg atggactggg tccgccagtc tccagagaag gggcttgagt      240

gggttgctga aattggaaac aaaggtaata atcatgcaac gtactatgct gagtctgtga      300

aagggaggtt caccgtctca agagatgatt ccaaaagtag agtctacctg caaatgaaca      360

gcttaagagt tgaagacact ggcacttatt actgtaccac gcggtttgct tactggggcc      420

aagggactct ggtcactgtc tctgcagcca aaacgacacc cccatctgtc tatccactgg      480

cccctggatc tgctgcccaa actaactcca tggtgaccct gggatgcctg gtcaagggct      540

atttccctga gccagtgaca gtgacctgga actctggatc cctgtccagc ggtgtgcaca      600

ccttcccagc tgtcctgcag tctgacctct acactctgag cagctcagtg actgtcccct      660

ccagcacctg gcccagcgag accgtcacct gcaacgttgc ccacccggcc agcagcacca      720

aggtggacaa gaaaattgtg cccagggatt gtggttgtaa gccttgcata tgtacagtcc      780

cagaagtatc atctgtcttc atcttccccc caaagcccaa ggatgtgctc accattactc      840

tgactcctaa ggtcacgtgt gttgtggtag acatcagcaa ggatgatccc gaggtccagt      900

tcagctggtt tgtagatgat gtggaggtgc acacagctca gacgcaaccc cgggaggagc      960

agttcaacag cactttccgc tcagtcagtg aacttcccat catgcaccag gactggctca     1020

atggcaagga gttcaaatgc agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa     1080

ccatctccaa aaccaaaggc agaccgaagg ctccacaggt gtacaccatt ccacctccca     1140

aggagcagat ggccaaggat aaagtcagtc tgacctgcat gataacagac ttcttccctg     1200

aagacattac tgtggagtgg cagtggaatg ggcagccagc ggagaactac aagaacactc     1260

agcccatcat ggacacagat ggctcttact tcgtctacag caagctcaat gtgcagaaga     1320

gcaactggga ggcaggaaat actttcacct gctctgtgtt acatgagggc ctgcacaacc     1380

accatactga gaagagcctc tcccactctc ctggtaaatg atcccagtgt ccttggagcc     1440

ctctggtcca tcaggactct gacacctacc tccacccctc cctgtataaa taaaagagcc     1500

cagcactgcc ttggg                                                      1515


<210>  64
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Arg Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr 
            100                 105                 110         


Gly Thr Tyr Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
225                 230                 235                 240 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
        275                 280                 285             


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
    290                 295                 300                 


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
                325                 330                 335     


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            340                 345                 350         


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
        355                 360                 365             


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
    370                 375                 380                 


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
385                 390                 395                 400 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
                405                 410                 415     


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
            420                 425                 430         


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
        435                 440                 445             


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455             


<210>  65
<211>  1994
<212>  DNA
<213>  Homo sapiens

<400>  65
aaacttcccg cacgcgttac aggagccagg tcggtataag cgccagcggc ctcgccgccc       60

gtcaagctgt ccacatccct ggcctcagcc cgccacatca ccctgacctg cttacgccca      120

gattttcttc aatcacatct gaataaatca cttgaagaaa gcttatagct tcattgcacc      180

atgtgtggca tttgggcgct gtttggcagt gatgattgcc tttctgttca gtgtctgagt      240

gctatgaaga ttgcacacag aggtccagat gcattccgtt ttgagaatgt caatggatac      300

accaactgct gctttggatt tcaccggttg gcggtagttg acccgctgtt tggaatgcag      360

ccaattcgag tgaagaaata tccgtatttg tggctctgtt acaatggtga aatctacaac      420

cataagaaga tgcaacagca ttttgaattt gaataccaga ccaaagtgga tggtgagata      480

atccttcatc tttatgacaa aggaggaatt gagcaaacaa tttgtatgtt ggatggtgtg      540

tttgcatttg ttttactgga tactgccaat aagaaagtgt tcctgggtag agatacatat      600

ggagtcagac ctttgtttaa agcaatgaca gaagatggat ttttggctgt atgttcagaa      660

gctaaaggtc ttgttacatt gaagcactcc gcgactccct ttttaaaagt ggagcctttt      720

cttcctggac actatgaagt tttggattta aagccaaatg gcaaagttgc atccgtggaa      780

atggttaaat atcatcactg tcgggatgaa cccctgcacg ccctctatga caatgtggag      840

aaactctttc caggttttga gatagaaact gtgaagaaca acctcaggat cctttttaat      900

aatgctgtaa agaaacgttt gatgacagac agaaggattg gctgcctttt atcagggggc      960

ttggactcca gcttggttgc tgccactctg ttgaagcagc tgaaagaagc ccaagtacag     1020

tatcctctcc agacatttgc aattggcatg gaagacagcc ccgatttact ggctgctaga     1080

aaggtggcag atcatattgg aagtgaacat tatgaagtcc tttttaactc tgaggaaggc     1140

attcaggctc tggatgaagt catattttcc ttggaaactt atgacattac aacagttcgt     1200

gcttcagtag gtatgtattt aatttccaag tatattcgga agaacacaga tagcgtggtg     1260

atcttctctg gagaaggatc agatgaactt acgcagggtt acatatattt tcacaaggct     1320

ccttctcctg aaaaagccga ggaggagagt gagaggcttc tgagggaact ctatttgttt     1380

gatgttctcc gcgcagatcg aactactgct gcccatggtc ttgaactgag agtcccattt     1440

ctagatcatc gattttcttc ctattacttg tctctgccac cagaaatgag aattccaaag     1500

aatgggatag aaaaacatct cctgagagag acgtttgagg attccaatct gatacccaaa     1560

gagattctct ggcgaccaaa agaagccttc agtgatggaa taacttcagt taagaattcc     1620

tggtttaaga ttttacagga atacgttgaa catcaggttg atgatgcaat gatggcaaat     1680

gcagcccaga aatttccctt caatactcct aaaaccaaag aaggatatta ctaccgtcaa     1740

gtctttgaac gccattaccc aggccgggct gactggctga gccattactg gatgcccaag     1800

tggatcaatg ccactgaccc ttctgcccgc acgctgaccc actacaagtc agctgtcaaa     1860

gcttaggtgg tctttatgct gtaatgtgaa agcaaatatt tcttcgtgtt ggatggggac     1920

tgtgggtaga taggggaaca atgagagtca actcaggcta acttgggtgt gaaaaaaata     1980

aaagtcctaa atct                                                       1994


<210>  66
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Cys Gly Ile Trp Ala Leu Phe Gly Ser Asp Asp Cys Leu Ser Val 
1               5                   10                  15      


Gln Cys Leu Ser Ala Met Lys Ile Ala His Arg Gly Pro Asp Ala Phe 
            20                  25                  30          


Arg Phe Glu Asn Val Asn Gly Tyr Thr Asn Cys Cys Phe Gly Phe His 
        35                  40                  45              


Arg Leu Ala Val Val Asp Pro Leu Phe Gly Met Gln Pro Ile Arg Val 
    50                  55                  60                  


Lys Lys Tyr Pro Tyr Leu Trp Leu Cys Tyr Asn Gly Glu Ile Tyr Asn 
65                  70                  75                  80  


His Lys Lys Met Gln Gln His Phe Glu Phe Glu Tyr Gln Thr Lys Val 
                85                  90                  95      


Asp Gly Glu Ile Ile Leu His Leu Tyr Asp Lys Gly Gly Ile Glu Gln 
            100                 105                 110         


Thr Ile Cys Met Leu Asp Gly Val Phe Ala Phe Val Leu Leu Asp Thr 
        115                 120                 125             


Ala Asn Lys Lys Val Phe Leu Gly Arg Asp Thr Tyr Gly Val Arg Pro 
    130                 135                 140                 


Leu Phe Lys Ala Met Thr Glu Asp Gly Phe Leu Ala Val Cys Ser Glu 
145                 150                 155                 160 


Ala Lys Gly Leu Val Thr Leu Lys His Ser Ala Thr Pro Phe Leu Lys 
                165                 170                 175     


Val Glu Pro Phe Leu Pro Gly His Tyr Glu Val Leu Asp Leu Lys Pro 
            180                 185                 190         


Asn Gly Lys Val Ala Ser Val Glu Met Val Lys Tyr His His Cys Arg 
        195                 200                 205             


Asp Glu Pro Leu His Ala Leu Tyr Asp Asn Val Glu Lys Leu Phe Pro 
    210                 215                 220                 


Gly Phe Glu Ile Glu Thr Val Lys Asn Asn Leu Arg Ile Leu Phe Asn 
225                 230                 235                 240 


Asn Ala Val Lys Lys Arg Leu Met Thr Asp Arg Arg Ile Gly Cys Leu 
                245                 250                 255     


Leu Ser Gly Gly Leu Asp Ser Ser Leu Val Ala Ala Thr Leu Leu Lys 
            260                 265                 270         


Gln Leu Lys Glu Ala Gln Val Gln Tyr Pro Leu Gln Thr Phe Ala Ile 
        275                 280                 285             


Gly Met Glu Asp Ser Pro Asp Leu Leu Ala Ala Arg Lys Val Ala Asp 
    290                 295                 300                 


His Ile Gly Ser Glu His Tyr Glu Val Leu Phe Asn Ser Glu Glu Gly 
305                 310                 315                 320 


Ile Gln Ala Leu Asp Glu Val Ile Phe Ser Leu Glu Thr Tyr Asp Ile 
                325                 330                 335     


Thr Thr Val Arg Ala Ser Val Gly Met Tyr Leu Ile Ser Lys Tyr Ile 
            340                 345                 350         


Arg Lys Asn Thr Asp Ser Val Val Ile Phe Ser Gly Glu Gly Ser Asp 
        355                 360                 365             


Glu Leu Thr Gln Gly Tyr Ile Tyr Phe His Lys Ala Pro Ser Pro Glu 
    370                 375                 380                 


Lys Ala Glu Glu Glu Ser Glu Arg Leu Leu Arg Glu Leu Tyr Leu Phe 
385                 390                 395                 400 


Asp Val Leu Arg Ala Asp Arg Thr Thr Ala Ala His Gly Leu Glu Leu 
                405                 410                 415     


Arg Val Pro Phe Leu Asp His Arg Phe Ser Ser Tyr Tyr Leu Ser Leu 
            420                 425                 430         


Pro Pro Glu Met Arg Ile Pro Lys Asn Gly Ile Glu Lys His Leu Leu 
        435                 440                 445             


Arg Glu Thr Phe Glu Asp Ser Asn Leu Ile Pro Lys Glu Ile Leu Trp 
    450                 455                 460                 


Arg Pro Lys Glu Ala Phe Ser Asp Gly Ile Thr Ser Val Lys Asn Ser 
465                 470                 475                 480 


Trp Phe Lys Ile Leu Gln Glu Tyr Val Glu His Gln Val Asp Asp Ala 
                485                 490                 495     


Met Met Ala Asn Ala Ala Gln Lys Phe Pro Phe Asn Thr Pro Lys Thr 
            500                 505                 510         


Lys Glu Gly Tyr Tyr Tyr Arg Gln Val Phe Glu Arg His Tyr Pro Gly 
        515                 520                 525             


Arg Ala Asp Trp Leu Ser His Tyr Trp Met Pro Lys Trp Ile Asn Ala 
    530                 535                 540                 


Thr Asp Pro Ser Ala Arg Thr Leu Thr His Tyr Lys Ser Ala Val Lys 
545                 550                 555                 560 


Ala 
    


<210>  67
<211>  3010
<212>  DNA
<213>  Homo sapiens

<400>  67
cgggaggagg cgcgggcgcg ccgggaggga ccggcggcgg catgggccgg gggccctggg       60

atgcgggccc gtctcgccgc ctgctgccgc tgttgctgct gctcggcctg gcccgcggcg      120

ccgcgggagc gccgggcccc gacggtttag acgtctgtgc cacttgccat gaacatgcca      180

catgccagca aagagaaggg aagaagatct gtatttgcaa ctatggattt gtagggaacg      240

ggaggactca gtgtgttgat aaaaatgagt gccagtttgg agccactctt gtctgtggga      300

accacacatc ttgccacaac acccccgggg gcttctattg catttgcctg gaaggatatc      360

gagccacaaa caacaacaag acattcattc ccaacgatgg caccttttgt acagacatag      420

atgagtgtga agtttctggc ctgtgcaggc atggagggcg atgcgtgaac actcatggga      480

gctttgaatg ctactgtatg gatggatact tgccaaggaa tggacctgaa cctttccacc      540

cgaccaccga tgccacatca tgcacagaaa tagactgtgg tacccctcct gaggttccag      600

atggctatat cataggaaat tatacgtcta gtctgggcag ccaggttcgt tatgcttgca      660

gagaaggatt cttcagtgtt ccagaagata cagtttcaag ctgcacaggc ctgggcacat      720

gggagtcccc aaaattacat tgccaagaga tcaactgtgg caaccctcca gaaatgcggc      780

acgccatctt ggtaggaaat cacagctcca ggctgggcgg tgtggctcgc tatgtctgtc      840

aagagggctt tgagagccct ggaggaaaga tcacttctgt ttgcacagag aaaggcacct      900

ggagagaaag tactttaaca tgcacagaaa ttctgacaaa gattaatgat gtatcactgt      960

ttaatgatac ctgtgtgaga tggcaaataa actcaagaag aataaacccc aagatctcat     1020

atgtgatatc cataaaagga caacggttgg accctatgga atcagttcgt gaggagacag     1080

tcaacttgac cacagacagc aggaccccag aagtgtgcct agccctgtac ccaggcacca     1140

actacaccgt gaacatctcc acagcacctc ccaggcgctc gatgccagcc gtcatcggtt     1200

tccagacagc tgaagttgat ctcttagaag atgatggaag tttcaatatt tcaatattta     1260

atgaaacttg tttgaaattg aacaggcgtt ctaggaaagt tggatcagaa cacatgtacc     1320

aatttaccgt tctgggtcag aggtggtatc tggctaactt ttctcatgca acatcgttta     1380

acttcacaac gagggaacaa gtgcctgtag tgtgtttgga tctgtaccct acgactgatt     1440

atacggtgaa tgtgaccctg ctgagatctc ctaagcggca ctcagtgcaa ataacaatag     1500

caactccccc agcagtaaaa cagaccatca gtaacatttc aggatttaat gaaacctgct     1560

tgagatggag aagcatcaag acagctgata tggaggagat gtatttattc cacatttggg     1620

gccagagatg gtatcagaag gaatttgccc aggaaatgac ctttaatatc agtagcagca     1680

gccgagatcc cgaggtgtgc ttggacctac gtccgggtac caactacaat gtcagtctcc     1740

gggctctgtc ttcggaactt cctgtggtca tctccctgac aacccagata acagagcctc     1800

ccctcccgga agtagaattt tttacggtgc acagaggacc tctaccacgc ctcagactga     1860

ggaaagccaa ggagaaaaat ggaccaatca gttcatatca ggtgttagtg cttcccctgg     1920

ccctccaaag cacattttct tgtgattctg aaggcgcttc ctccttcttt agcaacgcct     1980

ctgatgctga tggatacgtg gctgcagaac tactggccaa agatgttcca gatgatgcca     2040

tggagatacc tataggagac aggctgtact atggggaata ttataatgca cccttgaaaa     2100

gagggagtga ttactgcatt atattacgaa tcacaagtga atggaataag gtgagaagac     2160

actcctgtgc agtttgggct caggtgaaag attcgtcact catgctgctg cagatggcgg     2220

gtgttggact gggttccctg gctgttgtga tcattctcac attcctctcc ttctcagcgg     2280

tgtgatggca gatggacact gagtggggag gatgcactgc tgctgggcag gtgttctggc     2340

agcttctcag gtgcccgcac agaggctccg tgtgacttcc gtccagggag catgtgggcc     2400

tgcaactttc tccattccca gctgggcccc attcctggat ttaagatggt ggctatccct     2460

gaggagtcac cataaggaga aaactcagga attctgagtc ttccctgcta caggaccagt     2520

tctgtgcaat gaacttgaga ctcctgatgt acactgtgat attgaccgaa ggctacatac     2580

agatctgtga atcttggctg ggacttcctc tgagtgatgc ctgagggtca gctcctctag     2640

acattgactg caagagaatc tctgcaacct cctatataaa agcatttctg ttaattcatt     2700

cagaatccat tctttacaat atgcagtgag atgggcttaa gtttgggcta gagtttgact     2760

ttatgaagga ggtcattgaa aaagagaaca gtgacgtagg caaatgtttc aagcacttta     2820

gaaacagtac ttttcctata attagttgat atactaatga gaaaatatac tagcctggcc     2880

atgccaataa gtttcctgct gtgtctgtta ggcagcattg ctttgatgca atttctattg     2940

tcctatatat tcaaaagtaa tgtctacatt ccagtaaaaa tatcccgtaa ttaagaaaaa     3000

aaaaaaaaaa                                                            3010


<210>  68
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gly Arg Gly Pro Trp Asp Ala Gly Pro Ser Arg Arg Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Leu Ala Arg Gly Ala Ala Gly Ala Pro Gly 
            20                  25                  30          


Pro Asp Gly Leu Asp Val Cys Ala Thr Cys His Glu His Ala Thr Cys 
        35                  40                  45              


Gln Gln Arg Glu Gly Lys Lys Ile Cys Ile Cys Asn Tyr Gly Phe Val 
    50                  55                  60                  


Gly Asn Gly Arg Thr Gln Cys Val Asp Lys Asn Glu Cys Gln Phe Gly 
65                  70                  75                  80  


Ala Thr Leu Val Cys Gly Asn His Thr Ser Cys His Asn Thr Pro Gly 
                85                  90                  95      


Gly Phe Tyr Cys Ile Cys Leu Glu Gly Tyr Arg Ala Thr Asn Asn Asn 
            100                 105                 110         


Lys Thr Phe Ile Pro Asn Asp Gly Thr Phe Cys Thr Asp Ile Asp Glu 
        115                 120                 125             


Cys Glu Val Ser Gly Leu Cys Arg His Gly Gly Arg Cys Val Asn Thr 
    130                 135                 140                 


His Gly Ser Phe Glu Cys Tyr Cys Met Asp Gly Tyr Leu Pro Arg Asn 
145                 150                 155                 160 


Gly Pro Glu Pro Phe His Pro Thr Thr Asp Ala Thr Ser Cys Thr Glu 
                165                 170                 175     


Ile Asp Cys Gly Thr Pro Pro Glu Val Pro Asp Gly Tyr Ile Ile Gly 
            180                 185                 190         


Asn Tyr Thr Ser Ser Leu Gly Ser Gln Val Arg Tyr Ala Cys Arg Glu 
        195                 200                 205             


Gly Phe Phe Ser Val Pro Glu Asp Thr Val Ser Ser Cys Thr Gly Leu 
    210                 215                 220                 


Gly Thr Trp Glu Ser Pro Lys Leu His Cys Gln Glu Ile Asn Cys Gly 
225                 230                 235                 240 


Asn Pro Pro Glu Met Arg His Ala Ile Leu Val Gly Asn His Ser Ser 
                245                 250                 255     


Arg Leu Gly Gly Val Ala Arg Tyr Val Cys Gln Glu Gly Phe Glu Ser 
            260                 265                 270         


Pro Gly Gly Lys Ile Thr Ser Val Cys Thr Glu Lys Gly Thr Trp Arg 
        275                 280                 285             


Glu Ser Thr Leu Thr Cys Thr Glu Ile Leu Thr Lys Ile Asn Asp Val 
    290                 295                 300                 


Ser Leu Phe Asn Asp Thr Cys Val Arg Trp Gln Ile Asn Ser Arg Arg 
305                 310                 315                 320 


Ile Asn Pro Lys Ile Ser Tyr Val Ile Ser Ile Lys Gly Gln Arg Leu 
                325                 330                 335     


Asp Pro Met Glu Ser Val Arg Glu Glu Thr Val Asn Leu Thr Thr Asp 
            340                 345                 350         


Ser Arg Thr Pro Glu Val Cys Leu Ala Leu Tyr Pro Gly Thr Asn Tyr 
        355                 360                 365             


Thr Val Asn Ile Ser Thr Ala Pro Pro Arg Arg Ser Met Pro Ala Val 
    370                 375                 380                 


Ile Gly Phe Gln Thr Ala Glu Val Asp Leu Leu Glu Asp Asp Gly Ser 
385                 390                 395                 400 


Phe Asn Ile Ser Ile Phe Asn Glu Thr Cys Leu Lys Leu Asn Arg Arg 
                405                 410                 415     


Ser Arg Lys Val Gly Ser Glu His Met Tyr Gln Phe Thr Val Leu Gly 
            420                 425                 430         


Gln Arg Trp Tyr Leu Ala Asn Phe Ser His Ala Thr Ser Phe Asn Phe 
        435                 440                 445             


Thr Thr Arg Glu Gln Val Pro Val Val Cys Leu Asp Leu Tyr Pro Thr 
    450                 455                 460                 


Thr Asp Tyr Thr Val Asn Val Thr Leu Leu Arg Ser Pro Lys Arg His 
465                 470                 475                 480 


Ser Val Gln Ile Thr Ile Ala Thr Pro Pro Ala Val Lys Gln Thr Ile 
                485                 490                 495     


Ser Asn Ile Ser Gly Phe Asn Glu Thr Cys Leu Arg Trp Arg Ser Ile 
            500                 505                 510         


Lys Thr Ala Asp Met Glu Glu Met Tyr Leu Phe His Ile Trp Gly Gln 
        515                 520                 525             


Arg Trp Tyr Gln Lys Glu Phe Ala Gln Glu Met Thr Phe Asn Ile Ser 
    530                 535                 540                 


Ser Ser Ser Arg Asp Pro Glu Val Cys Leu Asp Leu Arg Pro Gly Thr 
545                 550                 555                 560 


Asn Tyr Asn Val Ser Leu Arg Ala Leu Ser Ser Glu Leu Pro Val Val 
                565                 570                 575     


Ile Ser Leu Thr Thr Gln Ile Thr Glu Pro Pro Leu Pro Glu Val Glu 
            580                 585                 590         


Phe Phe Thr Val His Arg Gly Pro Leu Pro Arg Leu Arg Leu Arg Lys 
        595                 600                 605             


Ala Lys Glu Lys Asn Gly Pro Ile Ser Ser Tyr Gln Val Leu Val Leu 
    610                 615                 620                 


Pro Leu Ala Leu Gln Ser Thr Phe Ser Cys Asp Ser Glu Gly Ala Ser 
625                 630                 635                 640 


Ser Phe Phe Ser Asn Ala Ser Asp Ala Asp Gly Tyr Val Ala Ala Glu 
                645                 650                 655     


Leu Leu Ala Lys Asp Val Pro Asp Asp Ala Met Glu Ile Pro Ile Gly 
            660                 665                 670         


Asp Arg Leu Tyr Tyr Gly Glu Tyr Tyr Asn Ala Pro Leu Lys Arg Gly 
        675                 680                 685             


Ser Asp Tyr Cys Ile Ile Leu Arg Ile Thr Ser Glu Trp Asn Lys Val 
    690                 695                 700                 


Arg Arg His Ser Cys Ala Val Trp Ala Gln Val Lys Asp Ser Ser Leu 
705                 710                 715                 720 


Met Leu Leu Gln Met Ala Gly Val Gly Leu Gly Ser Leu Ala Val Val 
                725                 730                 735     


Ile Ile Leu Thr Phe Leu Ser Phe Ser Ala Val 
            740                 745         


<210>  69
<211>  3006
<212>  DNA
<213>  Homo sapiens

<400>  69
gggggacagc acttctttca gtacattttc ctgttagact cggggtatta gagacccaaa       60

gatacccaag gaggagtgag agcgtccctg ccttcgagga gcagacaggg caccgcgagg      120

cgtttgcctc agcatggagg gcggggccgc ggcagccacc cccacagcac tgccttacta      180

cgtggccttc tcccagctgc tgggcctgac cttggtggcc atgaccggcg cgtggctcgg      240

gctgtaccga ggcggcattg cctgggagag cgacctgcag ttcaacgcgc accccctctg      300

catggtcata ggcctgatct tcctgcaggg aaatgccctg ctggtttacc gtgtcttcag      360

gaacgaagct aaacgcacca ccaaggtcct gcacgggctg ctgcacatct ttgcgctcgt      420

catcgccctg gttggcttgg tggcggtgtt cgactaccac aggaagaagg gctacgctga      480

cctgtacagc ctacacagct ggtgcgggat ccttgtcttt gtcctgtact ttgtgcagtg      540

gctggtgggc ttcagcttct tcctgttccc cggagcttca ttctccctgc ggagccgcta      600

ccgcccacag cacatcttct ttggtgctac catcttcctc ctttccgtgg gcaccgccct      660

gctgggcctg aaggaggcac tgctgttcaa cctcgggggc aagtatagcg catttgagcc      720

cgagggtgtc ctggccaacg tgctgggcct gctgctggcc tgcttcggtg gggcggtgct      780

ctacatcttg acccgggccg actggaagcg gccttcccag gcggaagagc aggccctctc      840

catggacttc aagacgctga cggagggaga tagccccggc tcccagtgat gcgcccggcc      900

ggccctgggg gttcgcgggg tgtcttcttg cctgcccctg ctgaggcgtc ttcaggactg      960

caggctccgg agagtggctc tggcagcagg cgggcgcgtg ggtgcagctg catctgtttg     1020

agtgctgctt tctggggtca ggtctccgcc tcctctgctt ctcctttctc cgctgctata     1080

gaccagttca ttgtgtgtgg ctcccgtgtc tctgttgccc ccttcagtgc agaaggcttt     1140

gggtaggact tcgggtgttc ggtcctggtc gcagagcaca gatctttaaa gaagcgagag     1200

aggaggcccc accctcctgg cagcagatgc ctggggcaag gccaggggaa actggggggg     1260

cctcagggac aggcctggaa aggccacgat ggctgctgaa ttcaaacaag gagtccctcc     1320

agcctgaata acacgtggca caaatgggcc cggcctttgg cagaggagca agtgatatga     1380

tgtgtaaagt atgttggtgg tgaaagcaag gttccccagg agaggggagg gactggcccc     1440

tgggaagctc tgagatgagg ctgtggccca gctgtagtcc tgaccttcct cttctttaac     1500

cctttagccc taggatggct ttggtgggag aggggataga agcccatgac ttcagacaga     1560

ctttctcttg gcagatgcag gcgggcctcc tcccaggctg ctccagacat gggggttggg     1620

gatggggggc accttgcagc cccttcctgc tggggctccc tccttgtagc accccccttg     1680

cggctcagct ctggtttcct ctcccaggct cacccaggct ctgctcaggc tgggaggcag     1740

agggcacaaa ccttataatt ttttaaatga aaaaccgctg ctgctggctg tggctagagc     1800

cccctggggc tgctggagct gctgcctctg ttctggagga cgagccttct ccttatctgc     1860

tgcccatctt tccaggaagt caggatggag tcagaacaac tacagtcatc ccccgtggtg     1920

tctgcacatc actccagccc cataaagagt gtcatgttag ctgagtcacc atttggcttc     1980

ggcctggaaa tagtgtgatt agaacactga tcgtgtgcga ggccaggaga tcaagaccat     2040

cctgactaac aaacacagtg aaaccccgtc tctactaaaa atacaaaaaa attagccagg     2100

cgtggtggtg ggcgcctgta gtcccagcta cttgggaggc tgaggcagga gaatggtgtg     2160

aacccgggag atggcgcttg cagtgagctg agattgcact ccagcctggg cgacaggctc     2220

aaaaaagaaa aaaaaaagaa caccgatcat gtgcttcttg gatctggtga ctgttctctc     2280

cctgttttcc tttctttttg ggtgtttgag gagcatggct tagcttgaga cacacacaga     2340

cactgtgtac ttcagtgaag ggcttaatat acagtttcca aacctgacga ctcttcttct     2400

tgtaatggct gcccttttcc tacctgaggc cgtcttagag aaaggggcca gtctcctcta     2460

atgctcagat ttcccatagt tggcttttgc tgtgtctcct gcctcaggca gtgtcatttc     2520

tgggagcagg tggttgtagt ccaggcccct ccccagcagg gtctgcccag gctccttcga     2580

gcccctttcc ccgcctcctc tcagcctgtc cggatgacag tgttcgcctc ctgtttagac     2640

tgtacactct tcaggggtag gggtgccgtc agttcttcaa tcagctggca cacacttgta     2700

tagtgaaatg tttacatgtg ggaaaactcc gccttagaca aactaccaaa gtacaatcgt     2760

gtctctctct agccggaatg ctacagagag aaatggaacc ttagatttgc aacaaaagtc     2820

tgtaaactgg tctgtttgcc aaagtgaaca ctggatgact aaggagctga agaaggcccc     2880

cagaagcgga tttgtggtgg gttattttat tttgcctgtg gccaatcttc tgtgaaatac     2940

aatgtgctgt tggtgcaaca gatgattcaa taaatgtcta cagcagaaaa aaaaaaaaaa     3000

aaaaaa                                                                3006


<210>  70
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Gly Gly Ala Ala Ala Ala Thr Pro Thr Ala Leu Pro Tyr Tyr 
1               5                   10                  15      


Val Ala Phe Ser Gln Leu Leu Gly Leu Thr Leu Val Ala Met Thr Gly 
            20                  25                  30          


Ala Trp Leu Gly Leu Tyr Arg Gly Gly Ile Ala Trp Glu Ser Asp Leu 
        35                  40                  45              


Gln Phe Asn Ala His Pro Leu Cys Met Val Ile Gly Leu Ile Phe Leu 
    50                  55                  60                  


Gln Gly Asn Ala Leu Leu Val Tyr Arg Val Phe Arg Asn Glu Ala Lys 
65                  70                  75                  80  


Arg Thr Thr Lys Val Leu His Gly Leu Leu His Ile Phe Ala Leu Val 
                85                  90                  95      


Ile Ala Leu Val Gly Leu Val Ala Val Phe Asp Tyr His Arg Lys Lys 
            100                 105                 110         


Gly Tyr Ala Asp Leu Tyr Ser Leu His Ser Trp Cys Gly Ile Leu Val 
        115                 120                 125             


Phe Val Leu Tyr Phe Val Gln Trp Leu Val Gly Phe Ser Phe Phe Leu 
    130                 135                 140                 


Phe Pro Gly Ala Ser Phe Ser Leu Arg Ser Arg Tyr Arg Pro Gln His 
145                 150                 155                 160 


Ile Phe Phe Gly Ala Thr Ile Phe Leu Leu Ser Val Gly Thr Ala Leu 
                165                 170                 175     


Leu Gly Leu Lys Glu Ala Leu Leu Phe Asn Leu Gly Gly Lys Tyr Ser 
            180                 185                 190         


Ala Phe Glu Pro Glu Gly Val Leu Ala Asn Val Leu Gly Leu Leu Leu 
        195                 200                 205             


Ala Cys Phe Gly Gly Ala Val Leu Tyr Ile Leu Thr Arg Ala Asp Trp 
    210                 215                 220                 


Lys Arg Pro Ser Gln Ala Glu Glu Gln Ala Leu Ser Met Asp Phe Lys 
225                 230                 235                 240 


Thr Leu Thr Glu Gly Asp Ser Pro Gly Ser Gln 
                245                 250     


<210>  71
<211>  2777
<212>  DNA
<213>  Homo sapiens

<400>  71
acataagtca cttaccaggt ctgtccctgc ggcatccagt ctgtgggtcc tgtcccatcc       60

atcctgacct gttccatctc agccccagga ctcagtactg cggttgccaa cactgctgcc      120

aggcatgatg gatgggccac gttccgatgt gggccgttgg ggtggcaacc ccttgcagcc      180

ccctaccacg ccatctccag agccagagcc agagccagac ggacgctctc gcagaggagg      240

aggccgttcc ttctgggctc gctgctgtgg ctgctgttca tgccgaaatg cggcagatga      300

cgactgggga cctgaaccct ctgactccag gggtcgaggg tccagctctg gcactcgaag      360

acctggctcc cggggctcag actcccgccg gcctgtatcc cggggcagcg gtgtcaatgc      420

agctggagat ggcaccatcc gagagggcat gctagtagtg aacggtgtgg acttgctgag      480

ctcgcgctcg gaccagaacc gccgagagca ccacacagac gagtatgagt acgacgagct      540

gatagtgcgc cgcgggcagc ctttccatat gctcctcctc ctgtcccgga cctatgaatc      600

ctctgatcgc atcacccttg agttactcat cggaaacaac cccgaggtgg gcaagggcac      660

gcacgtgatc atcccagtgg gcaagggggg cagtggaggc tggaaagccc aggtggtcaa      720

ggccagtggg cagaatctga acctgcgggt ccacacttcc cccaacgcca tcatcggcaa      780

gtttcagttc acagtccgca cacaatcaga cgctggggag ttccagttgc cctttgaccc      840

ccgcaatgag atctacatcc tcttcaaccc ctggtgccca gaggacattg tgtacgtgga      900

ccatgaggat tggcggcagg agtatgttct taatgagtct gggagaattt actacgggac      960

cgaagcacag attggtgagc ggacctggaa ctacggccag tttgaccacg gggtgctgga     1020

tgcctgctta tacatcctgg accggcgggg gatgccatat ggaggccgtg gagacccagt     1080

caatgtctcc cgggtcatct ctgccatggt gaactccctg gatgacaatg gagtcctgat     1140

tgggaactgg tctggtgatt actcccgagg caccaaccca tcagcgtggg tgggcagcgt     1200

ggagatcctg cttagctacc tacgcacggg atattccgtc ccctatggcc agtgctgggt     1260

ctttgctggc gtgaccacca cagtgctgcg ctgcctgggt ctggccaccc gtactgtcac     1320

caacttcaac tccgcccacg acacagacac atcccttacc atggacatct acttcgacga     1380

gaacatgaag cccctggagc acctgaacca tgattctgtc tggaacttcc atgtgtggaa     1440

cgactgctgg atgaagaggc cggatctgcc ctcgggcttt gatgggtggc aggtggtgga     1500

tgccacaccc caagagacta gcagtggcat cttctgctgc ggcccctgct ctgtggagtc     1560

catcaagaat ggcctggtct acatgaagta cgacacgcct ttcatttttg ctgaggtgaa     1620

tagtgacaag gtgtactggc agcggcagga tgatggcagc ttcaagattg tttatgtgga     1680

ggagaaggcc atcggcacac tcattgtcac aaaggccatc agctccaaca tgcgggagga     1740

catcacctac ctctataagc acccagaagg ctcagacgca gagcggaagg cagtagagac     1800

agcagcagcc cacggcagca aacccaatgt gtatgccaac cggggctcag cggaggatgt     1860

ggccatgcag gtggaggcac aggacgcggt gatggggcag gatctgatgg tctctgtgat     1920

gctgatcaat cacagcagca gccgccgcac agtgaaactg cacctctacc tctcagtcac     1980

tttctatact ggtgtcagtg gtaccatctt caaggagacc aagaaggaag tggagctggc     2040

accaggggcc tcggaccgtg tgaccatgcc agtggcctac aaggaatacc ggccccatct     2100

tgtggaccag ggggccatgc tgctcaatgt ctcaggccac gtcaaggaga gcgggcaggt     2160

gctggccaag cagcacacct tccgtctgcg caccccagac ctctccctca cgttactggg     2220

agcagcagtg gttggccagg agtgtgaagt acagattgtc ttcaagaacc cccttcccgt     2280

caccctcacc aatgtcgtct tccggctcga aggctctggg ttacagaggc ccaagatcct     2340

caacgttggg gacattggag gcaatgaaac agtgacactg cgccagtcgt ttgtgcctgt     2400

gcgaccaggc ccccgccagc tcattgccag cttggacagc ccacagctct cccaggtgca     2460

cggtgtcatc caggtggatg tggccccagc ccctggggat gggggcttct tctcagacgc     2520

tggaggtgac agtcacttag gagagaccat ccctatggca tctcgaggtg gagcttagcc     2580

ctgtgccagg agcaatggga ctggagtcag atgagcaagg acattgcccc aagatagggg     2640

cacactacag agcagctccc caggagctca ggtggggagt ccagggctcc cggaggggga     2700

gtccagggct cccggagagg gagtcagtct tcacttgcac tgggggaaca gatgctaata     2760

aactgttttt taatgaa                                                    2777


<210>  72
<211>  817
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Met Asp Gly Pro Arg Ser Asp Val Gly Arg Trp Gly Gly Asn Pro 
1               5                   10                  15      


Leu Gln Pro Pro Thr Thr Pro Ser Pro Glu Pro Glu Pro Glu Pro Asp 
            20                  25                  30          


Gly Arg Ser Arg Arg Gly Gly Gly Arg Ser Phe Trp Ala Arg Cys Cys 
        35                  40                  45              


Gly Cys Cys Ser Cys Arg Asn Ala Ala Asp Asp Asp Trp Gly Pro Glu 
    50                  55                  60                  


Pro Ser Asp Ser Arg Gly Arg Gly Ser Ser Ser Gly Thr Arg Arg Pro 
65                  70                  75                  80  


Gly Ser Arg Gly Ser Asp Ser Arg Arg Pro Val Ser Arg Gly Ser Gly 
                85                  90                  95      


Val Asn Ala Ala Gly Asp Gly Thr Ile Arg Glu Gly Met Leu Val Val 
            100                 105                 110         


Asn Gly Val Asp Leu Leu Ser Ser Arg Ser Asp Gln Asn Arg Arg Glu 
        115                 120                 125             


His His Thr Asp Glu Tyr Glu Tyr Asp Glu Leu Ile Val Arg Arg Gly 
    130                 135                 140                 


Gln Pro Phe His Met Leu Leu Leu Leu Ser Arg Thr Tyr Glu Ser Ser 
145                 150                 155                 160 


Asp Arg Ile Thr Leu Glu Leu Leu Ile Gly Asn Asn Pro Glu Val Gly 
                165                 170                 175     


Lys Gly Thr His Val Ile Ile Pro Val Gly Lys Gly Gly Ser Gly Gly 
            180                 185                 190         


Trp Lys Ala Gln Val Val Lys Ala Ser Gly Gln Asn Leu Asn Leu Arg 
        195                 200                 205             


Val His Thr Ser Pro Asn Ala Ile Ile Gly Lys Phe Gln Phe Thr Val 
    210                 215                 220                 


Arg Thr Gln Ser Asp Ala Gly Glu Phe Gln Leu Pro Phe Asp Pro Arg 
225                 230                 235                 240 


Asn Glu Ile Tyr Ile Leu Phe Asn Pro Trp Cys Pro Glu Asp Ile Val 
                245                 250                 255     


Tyr Val Asp His Glu Asp Trp Arg Gln Glu Tyr Val Leu Asn Glu Ser 
            260                 265                 270         


Gly Arg Ile Tyr Tyr Gly Thr Glu Ala Gln Ile Gly Glu Arg Thr Trp 
        275                 280                 285             


Asn Tyr Gly Gln Phe Asp His Gly Val Leu Asp Ala Cys Leu Tyr Ile 
    290                 295                 300                 


Leu Asp Arg Arg Gly Met Pro Tyr Gly Gly Arg Gly Asp Pro Val Asn 
305                 310                 315                 320 


Val Ser Arg Val Ile Ser Ala Met Val Asn Ser Leu Asp Asp Asn Gly 
                325                 330                 335     


Val Leu Ile Gly Asn Trp Ser Gly Asp Tyr Ser Arg Gly Thr Asn Pro 
            340                 345                 350         


Ser Ala Trp Val Gly Ser Val Glu Ile Leu Leu Ser Tyr Leu Arg Thr 
        355                 360                 365             


Gly Tyr Ser Val Pro Tyr Gly Gln Cys Trp Val Phe Ala Gly Val Thr 
    370                 375                 380                 


Thr Thr Val Leu Arg Cys Leu Gly Leu Ala Thr Arg Thr Val Thr Asn 
385                 390                 395                 400 


Phe Asn Ser Ala His Asp Thr Asp Thr Ser Leu Thr Met Asp Ile Tyr 
                405                 410                 415     


Phe Asp Glu Asn Met Lys Pro Leu Glu His Leu Asn His Asp Ser Val 
            420                 425                 430         


Trp Asn Phe His Val Trp Asn Asp Cys Trp Met Lys Arg Pro Asp Leu 
        435                 440                 445             


Pro Ser Gly Phe Asp Gly Trp Gln Val Val Asp Ala Thr Pro Gln Glu 
    450                 455                 460                 


Thr Ser Ser Gly Ile Phe Cys Cys Gly Pro Cys Ser Val Glu Ser Ile 
465                 470                 475                 480 


Lys Asn Gly Leu Val Tyr Met Lys Tyr Asp Thr Pro Phe Ile Phe Ala 
                485                 490                 495     


Glu Val Asn Ser Asp Lys Val Tyr Trp Gln Arg Gln Asp Asp Gly Ser 
            500                 505                 510         


Phe Lys Ile Val Tyr Val Glu Glu Lys Ala Ile Gly Thr Leu Ile Val 
        515                 520                 525             


Thr Lys Ala Ile Ser Ser Asn Met Arg Glu Asp Ile Thr Tyr Leu Tyr 
    530                 535                 540                 


Lys His Pro Glu Gly Ser Asp Ala Glu Arg Lys Ala Val Glu Thr Ala 
545                 550                 555                 560 


Ala Ala His Gly Ser Lys Pro Asn Val Tyr Ala Asn Arg Gly Ser Ala 
                565                 570                 575     


Glu Asp Val Ala Met Gln Val Glu Ala Gln Asp Ala Val Met Gly Gln 
            580                 585                 590         


Asp Leu Met Val Ser Val Met Leu Ile Asn His Ser Ser Ser Arg Arg 
        595                 600                 605             


Thr Val Lys Leu His Leu Tyr Leu Ser Val Thr Phe Tyr Thr Gly Val 
    610                 615                 620                 


Ser Gly Thr Ile Phe Lys Glu Thr Lys Lys Glu Val Glu Leu Ala Pro 
625                 630                 635                 640 


Gly Ala Ser Asp Arg Val Thr Met Pro Val Ala Tyr Lys Glu Tyr Arg 
                645                 650                 655     


Pro His Leu Val Asp Gln Gly Ala Met Leu Leu Asn Val Ser Gly His 
            660                 665                 670         


Val Lys Glu Ser Gly Gln Val Leu Ala Lys Gln His Thr Phe Arg Leu 
        675                 680                 685             


Arg Thr Pro Asp Leu Ser Leu Thr Leu Leu Gly Ala Ala Val Val Gly 
    690                 695                 700                 


Gln Glu Cys Glu Val Gln Ile Val Phe Lys Asn Pro Leu Pro Val Thr 
705                 710                 715                 720 


Leu Thr Asn Val Val Phe Arg Leu Glu Gly Ser Gly Leu Gln Arg Pro 
                725                 730                 735     


Lys Ile Leu Asn Val Gly Asp Ile Gly Gly Asn Glu Thr Val Thr Leu 
            740                 745                 750         


Arg Gln Ser Phe Val Pro Val Arg Pro Gly Pro Arg Gln Leu Ile Ala 
        755                 760                 765             


Ser Leu Asp Ser Pro Gln Leu Ser Gln Val His Gly Val Ile Gln Val 
    770                 775                 780                 


Asp Val Ala Pro Ala Pro Gly Asp Gly Gly Phe Phe Ser Asp Ala Gly 
785                 790                 795                 800 


Gly Asp Ser His Leu Gly Glu Thr Ile Pro Met Ala Ser Arg Gly Gly 
                805                 810                 815     


Ala 
    


<210>  73
<211>  11389
<212>  DNA
<213>  Homo sapiens

<400>  73
atggcgccgc cgccgccgcc cgtgctgccc gtgctgctgc tcctggccgc cgccgccgcc       60

ctgccggcga tggggctgcg agcggccgcc tgggagccgc gcgtacccgg cgggacccgc      120

gccttcgccc tccggcccgg ctgtacctac gcggtgggcg ccgcttgcac gccccgggcg      180

ccgcgggagc tgctggacgt gggccgcgat gggcggctgg caggacgtcg gcgcgtctcg      240

ggcgcggggc gcccgctgcc gctgcaagtc cgcttggtgg cccgcagtgc cccgacggcg      300

ctgagccgcc gcctgcgggc gcgcacgcac cttcccggct gcggagcccg tgcccggctc      360

tgcggaaccg gtgcccggct ctgcggggcg ctctgcttcc ccgtccccgg cggctgcgcg      420

gccgcgcagc attcggcgct cgcagctccg accaccttac ccgcctgccg ctgcccgccg      480

cgccccaggc cccgctgtcc cggccgtccc atctgcctgc cgccgggcgg ctcggtccgc      540

ctgcgtctgc tgtgcgccct gcggcgcgcg gctggcgccg tccgggtggg actggcgctg      600

gaggccgcca ccgcggggac gccctccgcg tcgccatccc catcgccgcc cctgccgccg      660

aacttgcccg aagcccgggc ggggccggcg cgacgggccc ggcggggcac gagcggcaga      720

gggagcctga agtttccgat gcccaactac caggtggcgt tgtttgagaa cgaaccggcg      780

ggcaccctca tcctccagct gcacgcgcac tacaccatcg agggcgagga ggagcgcgtg      840

agctattaca tggaggggct gttcgacgag cgctcccggg gctacttccg aatcgactct      900

gccacgggcg ccgtgagcac ggacagcgta ctggaccgcg agaccaagga gacgcacgtc      960

ctcagggtga aagccgtgga ctacagtacg ccgccgcgct cggccaccac ctacatcact     1020

gtcttggtca aagacaccaa cgaccacagc ccggtcttcg agcagtcgga gtaccgcgag     1080

cgcgtgcggg agaacctgga ggtgggctac gaggtgctga ccatccgcgc cagcgaccgc     1140

gactcgccca tcaacgccaa cttgcgttac cgcgtgttgg ggggcgcgtg ggacgtcttc     1200

cagctcaacg agagctctgg cgtggtgagc acacgggcgg tgctggaccg ggaggaggcg     1260

gccgagtacc agctcctggt ggaggccaac gaccaggggc gcaatccggg cccgctcagt     1320

gccacggcca ccgtgtacat cgaggtggag gacgagaacg acaactaccc ccagttcagc     1380

gagcagaact acgtggtcca ggtgcccgag gacgtggggc tcaacacggc tgtgctgcga     1440

gtgcaggcca cggaccggga ccagggccag aacgcggcca ttcactacag catcctcagc     1500

gggaacgtgg ccggccagtt ctacctgcac tcgctgagcg ggatcctgga tgtgatcaac     1560

cccttggatt tcgaggatgt ccagaaatac tcgctgagca ttaaggccca ggatgggggc     1620

cggcccccgc tcatcaattc ttcaggggtg gtgtctgtgc aggtgctgga tgtcaacgac     1680

aacgagccta tctttgtgag cagccccttc caggccacgg tgctggagaa tgtgcccctg     1740

ggctaccccg tggtgcacat tcaggcggtg gacgcggact ctggagagaa cgcccggctg     1800

cactatcgcc tggtggacac ggcctccacc tttctggggg gcggcagcgc tgggcctaag     1860

aatcctgccc ccacccctga cttccccttc cagatccaca acagctccgg ttggatcaca     1920

gtgtgtgccg agctggaccg cgaggaggtg gagcactaca gcttcggggt ggaggcggtg     1980

gaccacggct cgccccccat gagctcctcc accagcgtgt ccatcacggt gctggacgtg     2040

aatgacaacg acccggtgtt cacgcagccc acctacgagc ttcgtctgaa tgaggatgcg     2100

gccgtgggga gcagcgtgct gaccctgcag gcccgcgacc gtgacgccaa cagtgtgatt     2160

acctaccagc tcacaggcgg caacacccgg aaccgctttg cactcagcag ccagagaggg     2220

ggcggcctca tcaccctggc gctacctctg gactacaagc aggagcagca gtacgtgctg     2280

gcggtgacag catccgacgg cacacggtcg cacactgcgc atgtcctaat caacgtcact     2340

gatgccaaca cccacaggcc tgtctttcag agctcccatt acacagtgag tgtcagtgag     2400

gacaggcctg tgggcacctc cattgctacc ctcagtgcca acgatgagga cacaggagag     2460

aatgcccgca tcacctacgt gattcaggac cccgtgccgc agttccgcat tgaccccgac     2520

agtggcacca tgtacaccat gatggagctg gactatgaga accaggtcgc ctacacgctg     2580

accatcatgg cccaggacaa cggcatcccg cagaaatcag acaccaccac cctagagatc     2640

ctcatcctcg atgccaatga caatgcaccc cagttcctgt gggatttcta ccagggttcc     2700

atctttgagg atgctccacc ctcgaccagc atcctccagg tctctgccac ggaccgggac     2760

tcaggtccca atgggcgtct gctgtacacc ttccagggtg gggacgacgg cgatggggac     2820

ttctacatcg agcccacgtc cggtgtgatt cgcacccagc gccggctgga ccgggagaat     2880

gtggccgtgt acaacctttg ggctctggct gtggatcggg gcagtcccac tccccttagc     2940

gcctcggtag aaatccaggt gaccatcttg gacattaatg acaatgcccc catgtttgag     3000

aaggacgaac tggagctgtt tgttgaggag aacaacccag tggggtcggt ggtggcaaag     3060

attcgtgcta acgaccctga tgaaggccct aatgcccaga tcatgtatca gattgtggaa     3120

ggggacatgc ggcatttctt ccagctggac ctgctcaacg gggacctgcg tgccatggtg     3180

gagctggact ttgaggtccg gcgggagtat gtgctggtgg tgcaggccac gtcggctccg     3240

ctggtgagcc gagccacggt gcacatcctt ctcgtggacc agaatgacaa cccgcctgtg     3300

ctgcccgact tccagatcct cttcaacaac tatgtcacca acaagtccaa cagtttcccc     3360

accggcgtga tcggctgcat cccggcccat gaccccgacg tgtcagacag cctcaactac     3420

accttcgtgc agggcaacga gctgcgcctg ttgctgctgg accccgccac gggcgaactg     3480

cagctcagcc gcgacctgga caacaaccgg ccgctggagg cgctcatgga ggtgtctgtg     3540

tctgatggca tccacagcgt cacggccttc tgcaccctgc gtgtcaccat catcacggac     3600

gacatgctga ccaacagcat cactgtccgc ctggagaaca tgtcccagga gaagttcctg     3660

tccccgctgc tggccctctt cgtggagggg gtggccgccg tgctgtccac caccaaggac     3720

gacgtcttcg tcttcaacgt ccagaacgac accgacgtca gctccaacat cctgaacgtg     3780

accttctcgg cgctgctgcc tggcggcgtc cgcggccagt tcttcccgtc ggaggacctg     3840

caggagcaga tctacctgaa tcggacgctg ctgaccacca tctccacgca gcgcgtgctg     3900

cccttcgacg acaacatctg cctgcgcgag ccctgcgaga actacatgaa gtgcgtgtcc     3960

gttctgcgat tcgacagctc cgcgcccttc ctcagctcca ccaccgtgct cttccggccc     4020

atccacccca tcaacggcct gcgctgccgc tgcccgcccg gcttcaccgg cgactactgc     4080

gagacggaga tcgacctctg ctactccgac ccgtgcggcg ccaacggccg ctgccgcagc     4140

cgcgagggcg gctacacctg cgagtgcttc gaggacttca ctggagagca ctgtgaggtg     4200

gatgcccgct caggccgctg tgccaacggg gtgtgcaaga acgggggcac ctgcgtgaac     4260

ctgctcatcg gcggcttcca ctgcgtgtgt cctcctggcg agtatgagag gccctactgt     4320

gaggtgacca ccaggagctt cccgccccag tccttcgtca ccttccgggg cctgagacag     4380

cgcttccact tcaccatctc cctcacgttt gccactcagg aaaggaacgg cttgcttctc     4440

tacaacggcc gcttcaatga gaagcacgac ttcatcgccc tggagatcgt ggacgagcag     4500

gtgcagctca ccttctctgc aggcgagaca acaacgaccg tggcaccgaa ggttcccagt     4560

ggtgtgagtg acgggcggtg gcactctgtg caggtgcagt actacaacaa gcccaatatt     4620

ggccacctgg gcctgcccca tgggccgtcc ggggaaaaga tggccgtggt gacagtggat     4680

gattgtgaca caaccatggc tgtgcgcttt ggaaaggaca tcgggaacta cagctgcgct     4740

gcccagggca ctcagaccgg ctccaagaag tccctggatc tgaccggccc tctactcctg     4800

gggggtgtcc ccaacctgcc agaagacttc ccagtgcaca accggcagtt cgtgggctgc     4860

atgcggaacc tgtcagtcga cggcaaaaat gtggacatgg ccggattcat cgccaacaat     4920

ggcacccggg aaggctgcgc tgctcggagg aacttctgcg atgggaggcg gtgtcagaat     4980

ggaggcacct gtgtcaacag gtggaatatg tatctgtgtg agtgtccact ccgattcggc     5040

gggaagaact gtgagcaagc catgcctcac ccccagctct tcagcggtga gagcgtcgtg     5100

tcctggagtg acctgaacat catcatctct gtgccctggt acctggggct catgttccgg     5160

acccggaagg aggacagcgt tctgatggag gccaccagtg gtgggcccac cagctttcgc     5220

ctccagatcc tgaacaacta cctccagttt gaggtgtccc acggcccctc cgatgtggag     5280

tccgtgatgc tgtccgggtt gcgggtgacc gacggggagt ggcaccacct gctgatcgag     5340

ctgaagaatg ttaaggagga cagtgagatg aagcacctgg tcaccatgac cttggactat     5400

gggatggacc agaacaaggc agatatcggg ggcatgcttc ccgggctgac ggtaaggagc     5460

gtggtggtcg gaggcgcctc tgaagacaag gtctccgtgc gccgtggatt ccgaggctgc     5520

atgcagggag tgaggatggg ggggacgccc accaacgtcg ccaccctgaa catgaacaac     5580

gcactcaagg tcagggtgaa ggacggctgt gatgtggacg acccctgtac ctcgagcccc     5640

tgtcccccca atagccgctg ccacgacgcc tgggaggact acagctgcgt ctgtgacaaa     5700

gggtaccttg gaataaactg tgtggatgcc tgtcacctga acccctgcga gaacatgggg     5760

gcctgcgtgc gctcccccgg ctccccgcag ggctacgtgt gcgagtgtgg gcccagtcac     5820

tacgggccgt actgtgagaa caaactcgac cttccgtgcc ccagaggctg gtgggggaac     5880

cccgtctgtg gaccctgcca ctgtgccgtc agcaaaggct ttgatcccga ctgtaataag     5940

accaacggcc agtgccaatg caaggagaat tactacaagc tcctagccca ggacacctgt     6000

ctgccctgcg actgcttccc ccatggctcc cacagccgca cttgcgacat ggccaccggg     6060

cagtgtgcct gcaagcccgg cgtcatcggc cgccagtgca accgctgcga caacccgttt     6120

gccgaggtca ccacgctcgg ctgtgaagtg atctacaatg gctgtcccaa agcatttgag     6180

gccggcatct ggtggccaca gaccaagttc gggcagccgg ctgcggtgcc atgccctaag     6240

ggatccgttg gaaatgcggt ccgacactgc agcggggaga agggctggct gcccccagag     6300

ctctttaact gtaccaccat ctccttcgtg gacctcaggg ccatgaatga gaagctgagc     6360

cgcaatgaga cgcaggtgga cggcgccagg gccctgcagc tggtgagggc gctgcgcagt     6420

gctacacagc acacgggcac gctctttggc aatgacgtgc gcacggccta ccagctgctg     6480

ggccacgtcc ttcagcacga gagctggcag cagggcttcg acctggcagc cacgcaggac     6540

gccgactttc acgaggacgt catccactcg ggcagcgccc tcctggcccc agccaccagg     6600

gcggcgtggg agcagatcca gcggagcgag ggcggcacgg cacagctgct ccggcgcctc     6660

gagggctact tcagcaacgt ggcacgcaac gtgcggcgga cgtacctgcg gcccttcgtc     6720

atcgtcaccg ccaacatgat tcttgctgtc gacatctttg acaagttcaa ctttacggga     6780

gccagggtcc cgcgattcga caccatccat gaagagttcc ccagggagct ggagtcctcc     6840

gtctccttcc cagccgactt cttcagacca cctgaagaaa aagaaggccc cctgctgagg     6900

ccggctggcc ggaggaccac cccgcagacc acgcgcccgg ggcctggcac cgagagggag     6960

gccccgatca gcaggcggag gcgacaccct gatgacgctg gccagttcgc cgtcgctctg     7020

gtcatcattt accgcaccct ggggcagctc ctgcccgagc gctacgaccc cgaccgtcgc     7080

agcctccggt tgcctcaccg gcccatcatt aataccccga tggtgagcac gctggtgtac     7140

agcgaggggg ctccgctccc gagacccctg gagaggcccg tcctggtgga gttcgccctg     7200

ctggaggtgg aggagcgaac caagcctgtc tgcgtgttct ggaaccactc cctggccgtt     7260

ggtgggacgg gagggtggtc tgcccggggc tgcgagctcc tgtccaggaa ccggacacat     7320

gtcgcctgcc agtgcagcca cacagccagc tttgcggtgc tcatggatat ctccaggcgt     7380

gagaacgggg aggtcctgcc tctgaagatt gtcacctatg ccgctgtgtc cttgtcactg     7440

gcagccctgc tggtggcctt cgtcctcctg agcctggtcc gcatgctgcg ctccaacctg     7500

cacagcattc acaagcacct cgccgtggcg ctcttcctct ctcagctggt gttcgtgatt     7560

gggatcaacc agacggaaaa cccgtttctg tgcacagtgg ttgccatcct cctccactac     7620

atctacatga gcacctttgc ctggaccctc gtggagagcc tgcatgtcta ccgcatgctg     7680

accgaggtgc gcaacatcga cacggggccc atgcggttct actacgtcgt gggctggggc     7740

atcccggcca ttgtcacagg actggcggtc ggcctggacc cccagggcta cgggaacccc     7800

gacttctgct ggctgtcgct tcaagacacc ctgatttgga gctttgcggg gcccatcgga     7860

gctgttataa tcatcaacac agtcacttct gtcctatctg caaaggtttc ctgccaaaga     7920

aagcaccatt attatgggaa aaaagggatc gtctccctgc tgaggaccgc attcctcctg     7980

ctgctgctca tcagcgccac ctggctgctg gggctgctgg ctgtgaaccg cgatgcactg     8040

agctttcact acctcttcgc catcttcagc ggcttacagg gccccttcgt cctccttttc     8100

cactgcgtgc tcaaccagga ggtccggaag cacctgaagg gcgtgctcgg cgggaggaag     8160

ctgcacctgg aggactccgc caccaccagg gccaccctgc tgacgcgctc cctcaactgc     8220

aacaccacct tcggtgacgg gcctgacatg ctgcgcacag acttgggcga gtccaccgcc     8280

tcgctggaca gcatcgtcag ggatgaaggg atccagaagc tcggcgtgtc ctctgggctg     8340

gtgaggggca gccacggaga gccagacgcg tccctcatgc ccaggagctg caaggatccc     8400

cctggccacg attccgactc agatagcgag ctgtccctgg atgagcagag cagctcttac     8460

gcctcctcac actcgtcaga cagcgaggac gatggggtgg gagctgagga aaaatgggac     8520

ccggccaggg gcgccgtcca cagcaccccc aaaggggacg ctgtggccaa ccacgttccg     8580

gccggctggc ccgaccagag cctggctgag agtgacagtg aggaccccag cggcaagccc     8640

cgcctgaagg tggagaccaa ggtcagcgtg gagctgcacc gcgaggagca gggcagtcac     8700

cgtggagagt accccccgga ccaggagagc gggggcgcag ccaggcttgc tagcagccag     8760

cccccagagc agaggaaagg catcttgaaa aataaagtca cctacccgcc gccgctgacg     8820

ctgacggagc agacgctgaa gggccggctc cgggagaagc tggccgactg tgagcagagc     8880

cccacatcct cgcgcacgtc ttccctgggc tctggcggcc ccgactgcgc catcacagtc     8940

aagagccctg ggagggagcc ggggcgtgac cacctcaacg gggtggccat gaatgtgcgc     9000

actgggagcg cccaggccga tggctccgac tctgagaaac cgtgaggcaa gcccgtcacc     9060

ccacacaggc tgcggcatca ccctcagacc ttggagccca aggggccact gcccttgaag     9120

tggagtgggc ccagagtgtg gcggtcccca tggtggcagc cccccgactg atcatccaga     9180

cacaaaggtc ttggttctcc caggagctca gggcctgtca gacctggtga caagtgccaa     9240

aggccacagg catgagggag gcgtggacca ctgggccagc accgctgagt cctaagactg     9300

cagtcaaagc cagaactgag aggggacccc agactgggcc cagaggctgg ccagagttca     9360

ggaacgccgg gcacagacca aagaccgcgg tccagccccg cccaggcggg catctcatgg     9420

cagtgcggac ccgtggctgg cagcccgggc agtcctttgc aaaggcaccc cttgtcttaa     9480

aatcacttcg ctatgtggga aaggtggaga tacttttata tatttgtatg ggactctgag     9540

gaggtgcaac ctgtatatat attgcattcg tgctgacttt gttatcccga gagatccatg     9600

caatgatctc ttgctgtctt ctctgtcaag attgcacagt tgtacttgaa tctggcatgt     9660

gttgacgaaa ctggtgcccc agcagatcaa aggtgggaaa tacgtcagca gtggggctaa     9720

aaccaagcgg ctagaagccc tacagctgcc ttcggccagg aagtgaggat ggtgtgggcc     9780

ctccccgccg gccccctggg tccccagtgt tcgctgtgtg tgcgtttgtc ctctgctgcc     9840

atctgccccg gctgtgtgaa ttcaagacag ggcagtgcag cactaggcag gtgtgaggag     9900

ccctgctgag gtcactgtgg ggcacggttg ccacacggct gtcatttttc acctggtcat     9960

tctgtgacca ccaccccctc ccctcaccgc ctcccaggtg gcccgggagc tgcaggtggg    10020

gatggctttg tcctttgctc ctgctccccg tgggacctgg gaccttaaag cgttgcaggt    10080

tcctgatttg gacagaggtg tggggccttc caggccgtta catacctcct gccaattctc    10140

taactctctg agactgcgag gatctccagg cagggttctc ccctctggag tctgaccaat    10200

tacttcattt tgcttcaaat ggccaattgt gcagagggac aaagccacag ccacactctt    10260

caacggttac caaactgttt ttggaaattc acaccaaggt cgggcccact gcaggcagct    10320

ggcacagcgt ggcccgaggg gctgtggaac gggtcccgga actgtcagac atgtttgatt    10380

ttagcgtttc ctttgttctt caaatcaggt gcccaaataa gtgatcagca cagctgcttc    10440

caaataggag aaaccataaa ataggatgaa aatcaagtaa aatgcaaaga tgtccacact    10500

gttttaaact tgaccctgat gaaaatgtga gcactgttag cagatgccta tgggagagga    10560

aaagcgtatc tgaaaatggt ccaggacagg aggatgaaat gagatcccag agtcctcaca    10620

cctgaatgaa ttatacatgt gccttaccag gtgagtggtc tttcgaagat aaaaaactct    10680

agtcccttta aacgtttgcc cctggcgttt cctaagtacg aaaaggtttt taagtcttcg    10740

aacagtctcc tttcatgact ttaacaggat tctgccccct gaggtgtaat ttttttgttc    10800

tatttttttc cacgtactcc acagccaaca tcacgaggtg taatttttaa tttgatcaga    10860

actgttacca aaaaacaact gtcagtttta ttgagatggg aaaaatgtaa acctattttt    10920

attacttaag actttatggg agagattaga cactggaggt ttttaacaga acgtgtattt    10980

attaatgttc aaaacactgg aattacaaat gagaagagtc tacaataaat taagattttt    11040

gaatttgtac ttctgcggtg ctggtttttc tccacaaaca cccccgcccc tccccatgcc    11100

cagggtggcc gtggaaggga cggtttacgg acgtgcagct gagctgtccg tgtcccatgc    11160

tccctcagcc agtggaacgt gccggaactt tttgtccatt ccctagtagg cctgccacag    11220

cctagatggg cagtttttgt ctttcaccaa atttgaggac tttttttttt tgccattatt    11280

tcttcagttt tcttttcttg cactgatctt tctcctctcc ttctgtgact ccagtgactc    11340

agacgttaga cctcttgatg ttttcccact ggtccctgag gctctgttc                11389


<210>  74
<211>  3014
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala 
    290                 295                 300                 


Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr 
                325                 330                 335     


Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala 
        595                 600                 605             


Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser 
            660                 665                 670         


Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr 
        675                 680                 685             


Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr 
        755                 760                 765             


Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Thr Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Thr Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Thr Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1175                 1180                 1185             


Ala Phe  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1190                 1195                 1200             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Thr Thr Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1280                 1285                 1290             


Ile Ser  Thr Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Thr Thr  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Gly  Glu His Cys 
    1385                 1390                 1395             


Glu Val  Asp Ala Arg Ser Gly  Arg Cys Ala Asn Gly  Val Cys Lys 
    1400                 1405                 1410             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1415                 1420                 1425             


Val Cys  Pro Pro Gly Glu Tyr  Glu Arg Pro Tyr Cys  Glu Val Thr 
    1430                 1435                 1440             


Thr Arg  Ser Phe Pro Pro Gln  Ser Phe Val Thr Phe  Arg Gly Leu 
    1445                 1450                 1455             


Arg Gln  Arg Phe His Phe Thr  Ile Ser Leu Thr Phe  Ala Thr Gln 
    1460                 1465                 1470             


Glu Arg  Asn Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1475                 1480                 1485             


His Asp  Phe Ile Ala Leu Glu  Ile Val Asp Glu Gln  Val Gln Leu 
    1490                 1495                 1500             


Thr Phe  Ser Ala Gly Glu Thr  Thr Thr Thr Val Ala  Pro Lys Val 
    1505                 1510                 1515             


Pro Ser  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Gln Val Gln 
    1520                 1525                 1530             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1535                 1540                 1545             


Pro Ser  Gly Glu Lys Met Ala  Val Val Thr Val Asp  Asp Cys Asp 
    1550                 1555                 1560             


Thr Thr  Met Ala Val Arg Phe  Gly Lys Asp Ile Gly  Asn Tyr Ser 
    1565                 1570                 1575             


Cys Ala  Ala Gln Gly Thr Gln  Thr Gly Ser Lys Lys  Ser Leu Asp 
    1580                 1585                 1590             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1595                 1600                 1605             


Asp Phe  Pro Val His Asn Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1610                 1615                 1620             


Leu Ser  Val Asp Gly Lys Asn  Val Asp Met Ala Gly  Phe Ile Ala 
    1625                 1630                 1635             


Asn Asn  Gly Thr Arg Glu Gly  Cys Ala Ala Arg Arg  Asn Phe Cys 
    1640                 1645                 1650             


Asp Gly  Arg Arg Cys Gln Asn  Gly Gly Thr Cys Val  Asn Arg Trp 
    1655                 1660                 1665             


Asn Met  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1670                 1675                 1680             


Cys Glu  Gln Ala Met Pro His  Pro Gln Leu Phe Ser  Gly Glu Ser 
    1685                 1690                 1695             


Val Val  Ser Trp Ser Asp Leu  Asn Ile Ile Ile Ser  Val Pro Trp 
    1700                 1705                 1710             


Tyr Leu  Gly Leu Met Phe Arg  Thr Arg Lys Glu Asp  Ser Val Leu 
    1715                 1720                 1725             


Met Glu  Ala Thr Ser Gly Gly  Pro Thr Ser Phe Arg  Leu Gln Ile 
    1730                 1735                 1740             


Leu Asn  Asn Tyr Leu Gln Phe  Glu Val Ser His Gly  Pro Ser Asp 
    1745                 1750                 1755             


Val Glu  Ser Val Met Leu Ser  Gly Leu Arg Val Thr  Asp Gly Glu 
    1760                 1765                 1770             


Trp His  His Leu Leu Ile Glu  Leu Lys Asn Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Glu Met  Lys His Leu Val Thr  Met Thr Leu Asp Tyr  Gly Met Asp 
    1790                 1795                 1800             


Gln Asn  Lys Ala Asp Ile Gly  Gly Met Leu Pro Gly  Leu Thr Val 
    1805                 1810                 1815             


Arg Ser  Val Val Val Gly Gly  Ala Ser Glu Asp Lys  Val Ser Val 
    1820                 1825                 1830             


Arg Arg  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Gly 
    1835                 1840                 1845             


Thr Pro  Thr Asn Val Ala Thr  Leu Asn Met Asn Asn  Ala Leu Lys 
    1850                 1855                 1860             


Val Arg  Val Lys Asp Gly Cys  Asp Val Asp Asp Pro  Cys Thr Ser 
    1865                 1870                 1875             


Ser Pro  Cys Pro Pro Asn Ser  Arg Cys His Asp Ala  Trp Glu Asp 
    1880                 1885                 1890             


Tyr Ser  Cys Val Cys Asp Lys  Gly Tyr Leu Gly Ile  Asn Cys Val 
    1895                 1900                 1905             


Asp Ala  Cys His Leu Asn Pro  Cys Glu Asn Met Gly  Ala Cys Val 
    1910                 1915                 1920             


Arg Ser  Pro Gly Ser Pro Gln  Gly Tyr Val Cys Glu  Cys Gly Pro 
    1925                 1930                 1935             


Ser His  Tyr Gly Pro Tyr Cys  Glu Asn Lys Leu Asp  Leu Pro Cys 
    1940                 1945                 1950             


Pro Arg  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1955                 1960                 1965             


Ala Val  Ser Lys Gly Phe Asp  Pro Asp Cys Asn Lys  Thr Asn Gly 
    1970                 1975                 1980             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Leu Leu  Ala Gln Asp 
    1985                 1990                 1995             


Thr Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2000                 2005                 2010             


Thr Cys  Asp Met Ala Thr Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2015                 2020                 2025             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2030                 2035                 2040             


Thr Thr  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Lys Ala 
    2045                 2050                 2055             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Thr Lys Phe  Gly Gln Pro 
    2060                 2065                 2070             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2075                 2080                 2085             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2090                 2095                 2100             


Cys Thr  Thr Ile Ser Phe Val  Asp Leu Arg Ala Met  Asn Glu Lys 
    2105                 2110                 2115             


Leu Ser  Arg Asn Glu Thr Gln  Val Asp Gly Ala Arg  Ala Leu Gln 
    2120                 2125                 2130             


Leu Val  Arg Ala Leu Arg Ser  Ala Thr Gln His Thr  Gly Thr Leu 
    2135                 2140                 2145             


Phe Gly  Asn Asp Val Arg Thr  Ala Tyr Gln Leu Leu  Gly His Val 
    2150                 2155                 2160             


Leu Gln  His Glu Ser Trp Gln  Gln Gly Phe Asp Leu  Ala Ala Thr 
    2165                 2170                 2175             


Gln Asp  Ala Asp Phe His Glu  Asp Val Ile His Ser  Gly Ser Ala 
    2180                 2185                 2190             


Leu Leu  Ala Pro Ala Thr Arg  Ala Ala Trp Glu Gln  Ile Gln Arg 
    2195                 2200                 2205             


Ser Glu  Gly Gly Thr Ala Gln  Leu Leu Arg Arg Leu  Glu Gly Tyr 
    2210                 2215                 2220             


Phe Ser  Asn Val Ala Arg Asn  Val Arg Arg Thr Tyr  Leu Arg Pro 
    2225                 2230                 2235             


Phe Val  Ile Val Thr Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2240                 2245                 2250             


Asp Lys  Phe Asn Phe Thr Gly  Ala Arg Val Pro Arg  Phe Asp Thr 
    2255                 2260                 2265             


Ile His  Glu Glu Phe Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2270                 2275                 2280             


Pro Ala  Asp Phe Phe Arg Pro  Pro Glu Glu Lys Glu  Gly Pro Leu 
    2285                 2290                 2295             


Leu Arg  Pro Ala Gly Arg Arg  Thr Thr Pro Gln Thr  Thr Arg Pro 
    2300                 2305                 2310             


Gly Pro  Gly Thr Glu Arg Glu  Ala Pro Ile Ser Arg  Arg Arg Arg 
    2315                 2320                 2325             


His Pro  Asp Asp Ala Gly Gln  Phe Ala Val Ala Leu  Val Ile Ile 
    2330                 2335                 2340             


Tyr Arg  Thr Leu Gly Gln Leu  Leu Pro Glu Arg Tyr  Asp Pro Asp 
    2345                 2350                 2355             


Arg Arg  Ser Leu Arg Leu Pro  His Arg Pro Ile Ile  Asn Thr Pro 
    2360                 2365                 2370             


Met Val  Ser Thr Leu Val Tyr  Ser Glu Gly Ala Pro  Leu Pro Arg 
    2375                 2380                 2385             


Pro Leu  Glu Arg Pro Val Leu  Val Glu Phe Ala Leu  Leu Glu Val 
    2390                 2395                 2400             


Glu Glu  Arg Thr Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2405                 2410                 2415             


Ala Val  Gly Gly Thr Gly Gly  Trp Ser Ala Arg Gly  Cys Glu Leu 
    2420                 2425                 2430             


Leu Ser  Arg Asn Arg Thr His  Val Ala Cys Gln Cys  Ser His Thr 
    2435                 2440                 2445             


Ala Ser  Phe Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu Asn Gly 
    2450                 2455                 2460             


Glu Val  Leu Pro Leu Lys Ile  Val Thr Tyr Ala Ala  Val Ser Leu 
    2465                 2470                 2475             


Ser Leu  Ala Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2480                 2485                 2490             


Arg Met  Leu Arg Ser Asn Leu  His Ser Ile His Lys  His Leu Ala 
    2495                 2500                 2505             


Val Ala  Leu Phe Leu Ser Gln  Leu Val Phe Val Ile  Gly Ile Asn 
    2510                 2515                 2520             


Gln Thr  Glu Asn Pro Phe Leu  Cys Thr Val Val Ala  Ile Leu Leu 
    2525                 2530                 2535             


His Tyr  Ile Tyr Met Ser Thr  Phe Ala Trp Thr Leu  Val Glu Ser 
    2540                 2545                 2550             


Leu His  Val Tyr Arg Met Leu  Thr Glu Val Arg Asn  Ile Asp Thr 
    2555                 2560                 2565             


Gly Pro  Met Arg Phe Tyr Tyr  Val Val Gly Trp Gly  Ile Pro Ala 
    2570                 2575                 2580             


Ile Val  Thr Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2585                 2590                 2595             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Thr  Leu Ile Trp 
    2600                 2605                 2610             


Ser Phe  Ala Gly Pro Ile Gly  Ala Val Ile Ile Ile  Asn Thr Val 
    2615                 2620                 2625             


Thr Ser  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2630                 2635                 2640             


Tyr Tyr  Gly Lys Lys Gly Ile  Val Ser Leu Leu Arg  Thr Ala Phe 
    2645                 2650                 2655             


Leu Leu  Leu Leu Leu Ile Ser  Ala Thr Trp Leu Leu  Gly Leu Leu 
    2660                 2665                 2670             


Ala Val  Asn Arg Asp Ala Leu  Ser Phe His Tyr Leu  Phe Ala Ile 
    2675                 2680                 2685             


Phe Ser  Gly Leu Gln Gly Pro  Phe Val Leu Leu Phe  His Cys Val 
    2690                 2695                 2700             


Leu Asn  Gln Glu Val Arg Lys  His Leu Lys Gly Val  Leu Gly Gly 
    2705                 2710                 2715             


Arg Lys  Leu His Leu Glu Asp  Ser Ala Thr Thr Arg  Ala Thr Leu 
    2720                 2725                 2730             


Leu Thr  Arg Ser Leu Asn Cys  Asn Thr Thr Phe Gly  Asp Gly Pro 
    2735                 2740                 2745             


Asp Met  Leu Arg Thr Asp Leu  Gly Glu Ser Thr Ala  Ser Leu Asp 
    2750                 2755                 2760             


Ser Ile  Val Arg Asp Glu Gly  Ile Gln Lys Leu Gly  Val Ser Ser 
    2765                 2770                 2775             


Gly Leu  Val Arg Gly Ser His  Gly Glu Pro Asp Ala  Ser Leu Met 
    2780                 2785                 2790             


Pro Arg  Ser Cys Lys Asp Pro  Pro Gly His Asp Ser  Asp Ser Asp 
    2795                 2800                 2805             


Ser Glu  Leu Ser Leu Asp Glu  Gln Ser Ser Ser Tyr  Ala Ser Ser 
    2810                 2815                 2820             


His Ser  Ser Asp Ser Glu Asp  Asp Gly Val Gly Ala  Glu Glu Lys 
    2825                 2830                 2835             


Trp Asp  Pro Ala Arg Gly Ala  Val His Ser Thr Pro  Lys Gly Asp 
    2840                 2845                 2850             


Ala Val  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Gln Ser Leu 
    2855                 2860                 2865             


Ala Glu  Ser Asp Ser Glu Asp  Pro Ser Gly Lys Pro  Arg Leu Lys 
    2870                 2875                 2880             


Val Glu  Thr Lys Val Ser Val  Glu Leu His Arg Glu  Glu Gln Gly 
    2885                 2890                 2895             


Ser His  Arg Gly Glu Tyr Pro  Pro Asp Gln Glu Ser  Gly Gly Ala 
    2900                 2905                 2910             


Ala Arg  Leu Ala Ser Ser Gln  Pro Pro Glu Gln Arg  Lys Gly Ile 
    2915                 2920                 2925             


Leu Lys  Asn Lys Val Thr Tyr  Pro Pro Pro Leu Thr  Leu Thr Glu 
    2930                 2935                 2940             


Gln Thr  Leu Lys Gly Arg Leu  Arg Glu Lys Leu Ala  Asp Cys Glu 
    2945                 2950                 2955             


Gln Ser  Pro Thr Ser Ser Arg  Thr Ser Ser Leu Gly  Ser Gly Gly 
    2960                 2965                 2970             


Pro Asp  Cys Ala Ile Thr Val  Lys Ser Pro Gly Arg  Glu Pro Gly 
    2975                 2980                 2985             


Arg Asp  His Leu Asn Gly Val  Ala Met Asn Val Arg  Thr Gly Ser 
    2990                 2995                 3000             


Ala Gln  Ala Asp Gly Ser Asp  Ser Glu Lys Pro 
    3005                 3010                 


<210>  75
<211>  4006
<212>  DNA
<213>  Homo sapiens

<400>  75
tgccaaggct ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg       60

gctctgcggg ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc      120

cgcgcctacg gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg      180

cacagtaata tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta      240

ttttagtcat tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat      300

agaagtaccc ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga      360

gagtgagaag cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga      420

gtctgctgtg actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg      480

gctccctgga aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag      540

cctggaaaaa attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc      600

ctttgatctg accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt      660

caaggataat gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt      720

gaaacctgat cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca      780

atgggagaat ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa      840

cagccaaact gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga      900

atttgagaga aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac      960

tttgaacaca gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact     1020

ctggagtaat tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat     1080

aaccatgtta ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta     1140

cctaaaaagg ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa     1200

agaaatgttt ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga     1260

gaagcaaacc aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc     1320

tcagtgatgg agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt     1380

ctccatttgt tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa     1440

caggcagctc ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat     1500

aatgggcgct ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc     1560

ttcaaactag gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt     1620

tgtgacaact tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa     1680

ttttatttgt aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa     1740

gaacatgtag aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac     1800

catgtttgtg gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct     1860

gtaatcccag caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga     1920

ccagcctgac caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg     1980

tggtggcgcg tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa     2040

cctgggaggt ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac     2100

agagcaagac tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat     2160

attctggagt catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc     2220

agtgttggcc atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt     2280

caaagccatt ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt     2340

ttcaaccatg aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta     2400

ctgtgtcttt ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt     2460

acagtctatt tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt     2520

tttcagacct tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct     2580

tcccttcctt gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga     2640

cctggaggag cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat     2700

gactaattct tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc     2760

attttctaaa cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa     2820

aaaagaatag ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc     2880

tctgccataa atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa     2940

ggctctgttt atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac     3000

atatccgtat atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg     3060

agaggcattt cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa     3120

cttgagaact ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc     3180

tatttgcaat tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt     3240

gggtacaagt ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg     3300

aggaagctgg ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc     3360

tgggagacag ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg     3420

gttttcctgt ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca     3480

aaacccatgc ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg     3540

atgctgtgaa attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa     3600

gtgatctttt gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg     3660

aaaaggaagt tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg     3720

aggtgtctgt atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt     3780

tttaggtcta gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat     3840

ggtaattctt attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata     3900

tgtgaaacaa tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc     3960

ttataggaaa gcttgagtaa aataaatatt gtctttttgt atgtca                    4006


<210>  76
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  77
<211>  2168
<212>  DNA
<213>  Homo sapiens

<400>  77
ggctacgcag cttgctcctg gcacgggcac cttgaatctc ctcctcacac agatggagac       60

catgcttgat ttcctgaact tgtagtaaga agaaggaaaa cacagcacgc tggagccaac      120

agagttaaga ggaagattta tgagtcatgg aaccctccat cagatttgga agaaagtaga      180

atgagcgcag aggtgacaga cagccactga ggcccatgga caatctccac ctcacgcttc      240

tctatcaaac ttgaagattt attagtaata tgctgccttt ggaagatgaa aacaaactag      300

tgccaaggag gcgtattctt caatatttgg aatagacgtg ttctcaagac aatggcttca      360

aaggtctcct gtttgtatgt tttgacagtt gtgtgctggg ccagcgctct ctggtacttg      420

agtataactc gccctacttc ttcttacact ggctccaaac cattcagcca cctaacagtt      480

gccaggaaaa acttcacctt tggcaacata agaactcgac ctatcaaccc acattctttt      540

gaatttctta tcaacgagcc caataaatgt gagaaaaaca ttccttttct tgttatcctc      600

atcagcacca ctcacaagga atttgatgcc cgtcaggcaa tcagagagac gtggggggat      660

gagaacaact ttaaggggat caagatagcc accctgttcc tcctgggcaa gaatgctgat      720

cctgttctca atcagatggt ggagcaagag agccaaatct tccatgatat catcgtggag      780

gactttattg actcctacca taaccttacc ctcaaaacat taatggggat gagatgggtg      840

gccacttttt gttcaaaagc caagtatgtc atgaaaacag acagcgacat ttttgtaaac      900

atggacaatc ttatttataa attactgaaa ccctccacca agccacgaag aaggtatttt      960

actggctatg tcattaatgg aggaccgatt cgggatgtcc gcagtaaatg gtatatgccc     1020

agggatttgt acccagacag taactaccca cctttctgtt cggggactgg ctacatcttt     1080

tcagccgatg tagctgaact catttacaag acctcactcc acacaaggct gcttcacctt     1140

gaagacgtat atgtgggact gtgtcttcga aagctgggca tacatccttt ccagaacagt     1200

ggcttcaatc actggaaaat ggcctacagt ttgtgtaggt atcgccgagt tatcactgtg     1260

catcagatct ctccagaaga aatgcacaga atctggaatg acatgtcaag caagaaacat     1320

ctcagatgtt aggattttta ccaatgtaaa tatgtttctt ttcttttttt aagaaatggg     1380

acctaaggtg ttggtatttt ccaggtgtcg ggggaaatga actggtgaag gggttttgta     1440

aagtttttgc ttcctgctat aagttctttt cttggattac caatttatga atgttagact     1500

ctggtcatag aaacaataaa tgagttagaa gggccagatt tcattctcag tcccagagca     1560

ttgctattta tctcaaaaag tgacttccaa acaactctta ggattgacgt accgtgcatc     1620

tgagataaaa atttggttct gggaaactga aactcacagt aatgtgtcat atcatccctg     1680

caaaaattaa tacacaaata gaaaccattt tcaaaagcaa ttcagaaagg atgcacagtc     1740

aggaagacac actggatgtg attattaata tcgtgtgtgt tgttacatta tatttttaca     1800

tatattccca tgtaatgtgt acagtctttg cagttccacc aagaaatgaa cttggtacct     1860

gcagagtggc tgcagttaaa tagatgggag tttaaatttg agaatcaaac attctatgtg     1920

tttggaagac aactctgctt gctcatccaa ggattaaatc tggtcagcag gtggaatgtg     1980

tataaaatgc tacttaacaa agtaaacaaa agattttttt tttctttttt tttctttctt     2040

ttttgttttg ctctttcaga acaaacatta aatggtgcct ccaaggaaac tttgccaaat     2100

ataatctcac ctgcttcctt ccagacagtg tcgctaagtg catttcacag tttttggatc     2160

tggcaggc                                                              2168


<210>  78
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Ser Lys Val Ser Cys Leu Tyr Val Leu Thr Val Val Cys Trp 
1               5                   10                  15      


Ala Ser Ala Leu Trp Tyr Leu Ser Ile Thr Arg Pro Thr Ser Ser Tyr 
            20                  25                  30          


Thr Gly Ser Lys Pro Phe Ser His Leu Thr Val Ala Arg Lys Asn Phe 
        35                  40                  45              


Thr Phe Gly Asn Ile Arg Thr Arg Pro Ile Asn Pro His Ser Phe Glu 
    50                  55                  60                  


Phe Leu Ile Asn Glu Pro Asn Lys Cys Glu Lys Asn Ile Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Ile Ser Thr Thr His Lys Glu Phe Asp Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Glu Thr Trp Gly Asp Glu Asn Asn Phe Lys Gly Ile Lys Ile 
            100                 105                 110         


Ala Thr Leu Phe Leu Leu Gly Lys Asn Ala Asp Pro Val Leu Asn Gln 
        115                 120                 125             


Met Val Glu Gln Glu Ser Gln Ile Phe His Asp Ile Ile Val Glu Asp 
    130                 135                 140                 


Phe Ile Asp Ser Tyr His Asn Leu Thr Leu Lys Thr Leu Met Gly Met 
145                 150                 155                 160 


Arg Trp Val Ala Thr Phe Cys Ser Lys Ala Lys Tyr Val Met Lys Thr 
                165                 170                 175     


Asp Ser Asp Ile Phe Val Asn Met Asp Asn Leu Ile Tyr Lys Leu Leu 
            180                 185                 190         


Lys Pro Ser Thr Lys Pro Arg Arg Arg Tyr Phe Thr Gly Tyr Val Ile 
        195                 200                 205             


Asn Gly Gly Pro Ile Arg Asp Val Arg Ser Lys Trp Tyr Met Pro Arg 
    210                 215                 220                 


Asp Leu Tyr Pro Asp Ser Asn Tyr Pro Pro Phe Cys Ser Gly Thr Gly 
225                 230                 235                 240 


Tyr Ile Phe Ser Ala Asp Val Ala Glu Leu Ile Tyr Lys Thr Ser Leu 
                245                 250                 255     


His Thr Arg Leu Leu His Leu Glu Asp Val Tyr Val Gly Leu Cys Leu 
            260                 265                 270         


Arg Lys Leu Gly Ile His Pro Phe Gln Asn Ser Gly Phe Asn His Trp 
        275                 280                 285             


Lys Met Ala Tyr Ser Leu Cys Arg Tyr Arg Arg Val Ile Thr Val His 
    290                 295                 300                 


Gln Ile Ser Pro Glu Glu Met His Arg Ile Trp Asn Asp Met Ser Ser 
305                 310                 315                 320 


Lys Lys His Leu Arg Cys 
                325     


<210>  79
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  79
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgaca tcgtgatgac ccagtctcca gactccctgg ctgtgtctct gggcgagagg      120

gccaccatca actgcaagtc cagccagagt gttttataca gctccaacaa taagaactac      180

ttagcttggt accagcagaa accaggacag cctcctaagc tgctcattta ctgggcatct      240

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact      300

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat      360

agtactccgt acacttttgg ccaggggacc aagctggaga tcaaacgaac tgtggctgca      420

ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt      480

gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac      540

gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc      600

tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac      660

gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga      720

gagtgttcgg cgcgccagtc gactccattc gtttgtgaat atcaaggcca atcgtctgac      780

ctgcctcaac ctcctgtcaa tgctggcggc ggc                                   813


<210>  80
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Asp Ile Val Met Thr Gln Ser Pro Asp Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
    130                 135                 140                 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
145                 150                 155                 160 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
                165                 170                 175     


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
            180                 185                 190         


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
        195                 200                 205             


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
    210                 215                 220                 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
225                 230                 235                 240 


Glu Cys Ser Ala Arg Gln Ser Thr Pro Phe Val Cys Glu Tyr Gln Gly 
                245                 250                 255     


Gln Ser Ser Asp Leu Pro Gln Pro Pro Val Asn Ala Gly Gly Gly 
            260                 265                 270     


<210>  81
<211>  2210
<212>  DNA
<213>  Homo sapiens

<400>  81
agccgcggcc tcaactaaaa gtggccattg acctttcaag ctttcgagca gtgatgcaat       60

agaatagtat ttcaaagaaa aatgcttatc gaaattttgg atccggtttt cccgtgattg      120

ttaagggttt cttttaaaaa gtaggtcaca tttcaagtag gtcatatttc gggggcgggt      180

gcgcagacaa ggagatgagt ttccactaag gccagggggc ctccaacggg gttggaggtg      240

agaatcccag gtagggtaga ggtgccgaga tccttccgaa tcccagccct ggggcgtcag      300

ccctgcaggg aatggcagag acactctccg gactgaggga accgaggcca gtcaccaagc      360

cccttccggg cgcgcaggcg atcagtgggt gaccgcggct gcgagggact ttgtcatccg      420

tcctccagga tctggggaga aagagcccca tcccttctct ctctgccacc atttcggaca      480

ccccgcaggg actcgttttg ggattcgcac tgacttcaag gaaggacgcg aacccttctc      540

tgaccccagc tcgggcggcc acctgtcttt gccgcggtga cccttctctc atgaccctgc      600

ggtgccttga gccctccggg aatggcgggg aagggacgcg gagccagtgg gggaccgcgg      660

ggtcggcgga ggagccatcc ccgcaggcgg cgcgtctggc gaaggccctg cgggagctcg      720

gtcagacagg atggtactgg ggaagtatga ctgttaatga agccaaagag aaattaaaag      780

aggcaccaga aggaactttc ttgattagag atagctcgca ttcagactac ctactaacaa      840

tatctgttaa aacatcagct ggaccaacta atcttcgaat cgaataccaa gacggaaaat      900

tcagattgga ctctatcata tgtgtcaaat ccaagcttaa acaatttgac agtgtggttc      960

atctgatcga ctactatgtt cagatgtgca aggataagcg gacaggtcca gaagcccccc     1020

ggaacggcac tgttcacctt tatctgacca aaccgctcta cacgtcagca ccatctctgc     1080

agcatctctg taggctcacc attaacaaat gtaccggtgc catctgggga ctgcctttac     1140

caacaagact aaaagattac ttggaagaat ataaattcca ggtataaatg tttctctttt     1200

tttaaacatg tctcacatag agtatctccg aatgcagcta tgtaaaagag aaccaaaact     1260

tgagtgctct ggataactat atggaatgct ttctaagaac agctgaagct aatctaattt     1320

aaatttaaca gcttgaagag gtagctaggt gtttaaagtt cctccagata cttttacctg     1380

agtgatgctt cccttcctaa ggctgaccaa gacctgttga tccttttaga ttaaaaataa     1440

aatgtcgcat gtaaaggctg aagtcgcgtt ttatcagaat gccttgcctt cttaggttct     1500

tttccattat gtcaaaggtc caggctccag taggagagaa agaactcctc ataggaatac     1560

tgaagaagtg ggaaggaacc aagctgacac aggcctcact gcaatttgat atgcctgctg     1620

atcagagtct cttgggcatt ttatattttg cattctgatg tacctaggag ttttgttaaa     1680

cagatgatgt atgtgagtat ttatcccatt ttatgcaatt aaccaaatca accaaaaaaa     1740

gtgaccatga agtcctgtat ttgtcttttt actacatgta ggaactctca tgtgaatgag     1800

tactgtagta atccattcta tgggagcctt atttcagaaa tatttcaaac tggtgcaaat     1860

ggaaaagact ttctcttttc ctttaaagct aaagacaaga atatcatgct atacaggtgc     1920

aactcaatcc ccgttaataa aaaccaatgt aggtataggc attctaccct ttgaaatagc     1980

tgtgtcccaa cctgttgcca ttgatttttt ggaaatggct ttagaaatat ccaagttgtc     2040

cttgaattgt ctaaccatgg acataaacag ttgtctccct tctactgtgt agaatacttt     2100

gacttaattt tcttccagat acagggggat acctgcctgt ttttcaaagt gtttatttac     2160

tgctgttact atttgattag aatgtattaa ataaaaaaaa cctgatttct                2210


<210>  82
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210>  83
<211>  695
<212>  DNA
<213>  Homo sapiens

<400>  83
ggacactgca gccatataaa tcagattttt gacatgttat aaaatgcaag tcacagctgc       60

tgttgtctgc ggtattcaaa aacttttgaa acactgcatg tccaacaaaa tttatttttt      120

gtgtgaatgt actgtttttc aaccctactc tcttgaccaa gaatgaaact atttacaaat      180

taagatgcca acagatcacg aagagccctg tggtcccagt cacaagtcgt tttgcctgaa      240

tggggggctt tgttatgtga tacctactat tcccagccca ttttgtaggt gcgttgaaaa      300

ctatacagga gctcgttgtg aagaggtttt tctcccaggc tccagcatcc aaactaaaag      360

taacctgttt gaagcttttg tggcattggc ggtcctagta acacttatca ttggagcctt      420

ctacttcctt tgcaggaaag gccactttca gagagccagt tcagtccagt atgatatcaa      480

cctggtagag acgagcagta ccagtgccca ccacagtcat gaacaacact gaagaaacgt      540

caaagtgaac caaatcattg tttttatttt acaaaggcag aaaatgaaac accactaggt      600

aaaagaatta aaaatctaat cctttatttc ttaaataaaa cgcttgtgta actcgtatca      660

tgaaccaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                 695


<210>  84
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Pro Thr Asp His Glu Glu Pro Cys Gly Pro Ser His Lys Ser Phe 
1               5                   10                  15      


Cys Leu Asn Gly Gly Leu Cys Tyr Val Ile Pro Thr Ile Pro Ser Pro 
            20                  25                  30          


Phe Cys Arg Cys Val Glu Asn Tyr Thr Gly Ala Arg Cys Glu Glu Val 
        35                  40                  45              


Phe Leu Pro Gly Ser Ser Ile Gln Thr Lys Ser Asn Leu Phe Glu Ala 
    50                  55                  60                  


Phe Val Ala Leu Ala Val Leu Val Thr Leu Ile Ile Gly Ala Phe Tyr 
65                  70                  75                  80  


Phe Leu Cys Arg Lys Gly His Phe Gln Arg Ala Ser Ser Val Gln Tyr 
                85                  90                  95      


Asp Ile Asn Leu Val Glu Thr Ser Ser Thr Ser Ala His His Ser His 
            100                 105                 110         


Glu Gln His 
        115 


<210>  85
<211>  4146
<212>  DNA
<213>  Homo sapiens

<400>  85
gaccactgag acgagcggga gcgcggagca gcagcctctg ctgccctgac tttttaagaa       60

atctcaatga actatttgta gagaatcact gatccggcct gcaagcattt tgcacggcaa      120

aaatatcgat cagtgttaag tgaagatcac attttatatg cgatcttgac ttttttgtct      180

tacattatat ttttatagat tttgttataa acatggtgct gggaaaggtg aagagtttga      240

caataagctt tgactgtctt aatgacagca atgtccctgt gtattctagt ggggataccg      300

tctcaggaag ggtaaattta gaagttactg gggaaatcag agtaaaatct cttaaaattc      360

atgcaagagg acatgcgaaa gtacgctgga ctgaatctag aaacgccggc tccaatactg      420

cctatacaca gaattacact gaagaagtag agtatttcaa ccataaagac atcttaattg      480

ggcacgaaag agatgatgat aattccgaag aaggcttcca cactattcat tcaggaaggc      540

atgaatatgc attcagcttc gagcttccac agacaccact cgctacctca ttcgaaggcc      600

gacatggcag tgtgcgctat tgggtgaaag ccgaattgca caggccttgg ctactaccag      660

taaaattaaa gaaggaattt acagtctttg agcatataga tatcaacact ccttcattac      720

tgtcacccca agcaggcaca aaagaaaaga cactctgttg ctggttctgt acctcaggcc      780

caatatcctt aagtgccaaa attgaaagga agggctatac cccaggtgaa tcaattcaga      840

tatttgctga gattgagaac tgctcttccc gaatggtggt gccaaaggca gccatttacc      900

aaacacaggc cttctatgcc aaagggaaaa tgaaggaagt aaaacagctt gtggctaact      960

tgcgtgggga atccttatca tctggaaaga cagagacgtg gaatggcaag ttgctgaaaa     1020

ttccaccagt ttctccctct atcctcgact gtagtataat ccgcgtggaa tattcactaa     1080

tggtatatgt ggatattcct ggagctatgg atttatttct taatttgcca cttgtcatcg     1140

gtaccattcc tctacatcca tttggtagca gaacctcaag tgtaagcagt cagtgtagca     1200

tgaatatgaa ctggctcagt ttatcacttc ctgaaagacc tgaagcacca cccagctatg     1260

cagaagtggt aacagaggaa caaaggcgga acaatcttgc accagtgagt gcttgtgatg     1320

actttgagag agcccttcaa ggaccactgt ttgcatatat ccaggagttt cgattcttgc     1380

ctccacctct ttattcagag attgatccaa atcctgatca gtcagcagat gatagaccat     1440

cctgcccctc tcgttgaagg aacacttggt tgaatcaagt tgatgtgggt tccgaactgt     1500

atctcttccg gctgaggaca gagaagtatc ttggagacac gtttcagagg aagtggaatt     1560

acttttgccc agaaaaatgg cgaatacatg aaacaaccag tgatcatgct ttagaagcct     1620

acagcaacat tctgagactg ctccaacatg cttgaagatc taagcttttc tcttttaaaa     1680

ctggcacata ctcagagcag tcttcttagc ctatggtcgt acgtgtcaag acatcacgtt     1740

gtaaagaggg atgatttcct tcttttgatt tgaaaatttg cacatgctca atgcttacat     1800

tgtgcggttc gacgtcacta cagcttcttt tttttttttt ttttctattt ttgccagact     1860

cttgatactc ttaaaacttg tttgtggtca gcacaacaag gaacaaaaca aagctttgaa     1920

aaaactttaa catgaaaaaa cgcactgaca ttttttttta tttaatatag cctggacttt     1980

acctgcgtat gcacatgctc agaattgtct actaggctga ctatgtatca cctcttcagc     2040

ttggatccaa ttgtggattt atttacaaac atcaaatgcc ttcaagccaa tcctttttgc     2100

tgtatgtttt gcagcctact gtagtagata cgcaacagat aatgtgggaa aaaaagagat     2160

aagaggagga agctaataag agactgtcaa gattgtatac cttcttggtt tcttttaaga     2220

atttgttgcc tttctactat tacagcaaag cagcattttg ttactgactg cctaaaatca     2280

cttaatctca ggtgaacgca tcacttgcca aactgttgga atgctatttg tgttttgttg     2340

cactgttttt ttcgtttgtt tgtttgttta tttggttggc tttttggaga gggaaatttg     2400

gaaacgggac atacacaaaa gttacacacc cacattccct ttttatcatg acatacaaga     2460

agaaactagc agagctaaga atggagtgaa gaaaggcagt atggcaggca ccagcaaaga     2520

gttgagggct gttgctctta aaaattattt tttttattat tattttgaaa gtatggaagt     2580

tttccattca ctggggaaag gagggaaaag tgcatttatt tttatacaga gttacttaat     2640

tacctccaaa acacatatgt tggaaatcgc ttttgctggt gcaaagtata ttaatgagca     2700

ggaatacata cattgaggtt atgaatagag agctcaattt gtacctttgc tgtcttgctc     2760

aagcttggta tggcatgaaa actcgacttt attccaaaag taacttcaaa atttaaaata     2820

ctagaacgtt tgctgcgata aatcttttgg atttttgtgt ttttctaatg agaatactgt     2880

ttttcattac ctaaagaaca atttgctaaa catgagaaat cactcacttt gattatgtat     2940

agattacata ggaagaacaa tcacatcagt aagttatagt ttatattaaa ggtaattttc     3000

tgttggctca taacaaatat accagcattc atgatagcat ttcagcattt tccaaggtac     3060

caagtgtact tattttgttg ttgttgttgt tgttgtattt tagaaggaat tcagctctga     3120

tgtttttaaa gaaaaccagc atctctgatg ttgcaacata cgtgtaaaat gggtgttaca     3180

tctatcctgc catttaaccc cacagttaat aaagtggctg aaaataatag tagctctggc     3240

ttggtgcttg acctggttaa atactgtctt aaagctcata caaaacaaat aggcttttcc     3300

ataagtggcc tttaagaaaa catggaagac aattcatgtt tgacaaatgc tgacagggtg     3360

aagaaagccc agtgtaaaaa tgaatcgcgt tttaagtgat tcggttaaag agtttgggct     3420

cccgtagcaa actaatacta gataataagg aaatgggggt gaaatatttt tttattgttg     3480

aatcattttg tgaatgtccc cctcaaaaaa agctaatgga atatttggca taaagggcat     3540

ttggtggttt tatttttgtt tgagggggat tgtcagaaaa tcccttttct ctcttacgtc     3600

taactgacta gggaacaatt gttgatatgc atagcattgg aatacttgtc attatatact     3660

cttacaaata acacatgaag caagaatgac caatattctg ataattggca ctggatcaca     3720

aaatgtgata aaactttaaa tgtataaaac tttatcaaat aaagttttat tttccccttt     3780

aaaatgtatt tctttagagg cattactttt ttaaaaatat tggtcaattc ctgacataag     3840

atgtgaggtt cacagttgta ttccagtatt caagatagat tcctgatttt tcaattagga     3900

aaagtaaaat ccaaaatgtt agcaaaacaa agtgcaatat taaatgtttg ctttatagat     3960

tatattctat ggctgtttgt aatttctctt tttttccttt tttatttggt gctgaatatg     4020

tccttgtagg ctctgtttta agaaaacaat atgtgggaaa tgatttaatt tttcctattg     4080

ctcttccttg tggaaaataa agtgttttgt ttttttctgt tttgtataaa aaaaaaaaaa     4140

aaaaaa                                                                4146


<210>  86
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Val Leu Gly Lys Val Lys Ser Leu Thr Ile Ser Phe Asp Cys Leu 
1               5                   10                  15      


Asn Asp Ser Asn Val Pro Val Tyr Ser Ser Gly Asp Thr Val Ser Gly 
            20                  25                  30          


Arg Val Asn Leu Glu Val Thr Gly Glu Ile Arg Val Lys Ser Leu Lys 
        35                  40                  45              


Ile His Ala Arg Gly His Ala Lys Val Arg Trp Thr Glu Ser Arg Asn 
    50                  55                  60                  


Ala Gly Ser Asn Thr Ala Tyr Thr Gln Asn Tyr Thr Glu Glu Val Glu 
65                  70                  75                  80  


Tyr Phe Asn His Lys Asp Ile Leu Ile Gly His Glu Arg Asp Asp Asp 
                85                  90                  95      


Asn Ser Glu Glu Gly Phe His Thr Ile His Ser Gly Arg His Glu Tyr 
            100                 105                 110         


Ala Phe Ser Phe Glu Leu Pro Gln Thr Pro Leu Ala Thr Ser Phe Glu 
        115                 120                 125             


Gly Arg His Gly Ser Val Arg Tyr Trp Val Lys Ala Glu Leu His Arg 
    130                 135                 140                 


Pro Trp Leu Leu Pro Val Lys Leu Lys Lys Glu Phe Thr Val Phe Glu 
145                 150                 155                 160 


His Ile Asp Ile Asn Thr Pro Ser Leu Leu Ser Pro Gln Ala Gly Thr 
                165                 170                 175     


Lys Glu Lys Thr Leu Cys Cys Trp Phe Cys Thr Ser Gly Pro Ile Ser 
            180                 185                 190         


Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Thr Pro Gly Glu Ser Ile 
        195                 200                 205             


Gln Ile Phe Ala Glu Ile Glu Asn Cys Ser Ser Arg Met Val Val Pro 
    210                 215                 220                 


Lys Ala Ala Ile Tyr Gln Thr Gln Ala Phe Tyr Ala Lys Gly Lys Met 
225                 230                 235                 240 


Lys Glu Val Lys Gln Leu Val Ala Asn Leu Arg Gly Glu Ser Leu Ser 
                245                 250                 255     


Ser Gly Lys Thr Glu Thr Trp Asn Gly Lys Leu Leu Lys Ile Pro Pro 
            260                 265                 270         


Val Ser Pro Ser Ile Leu Asp Cys Ser Ile Ile Arg Val Glu Tyr Ser 
        275                 280                 285             


Leu Met Val Tyr Val Asp Ile Pro Gly Ala Met Asp Leu Phe Leu Asn 
    290                 295                 300                 


Leu Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro Phe Gly Ser Arg 
305                 310                 315                 320 


Thr Ser Ser Val Ser Ser Gln Cys Ser Met Asn Met Asn Trp Leu Ser 
                325                 330                 335     


Leu Ser Leu Pro Glu Arg Pro Glu Ala Pro Pro Ser Tyr Ala Glu Val 
            340                 345                 350         


Val Thr Glu Glu Gln Arg Arg Asn Asn Leu Ala Pro Val Ser Ala Cys 
        355                 360                 365             


Asp Asp Phe Glu Arg Ala Leu Gln Gly Pro Leu Phe Ala Tyr Ile Gln 
    370                 375                 380                 


Glu Phe Arg Phe Leu Pro Pro Pro Leu Tyr Ser Glu Ile Asp Pro Asn 
385                 390                 395                 400 


Pro Asp Gln Ser Ala Asp Asp Arg Pro Ser Cys Pro Ser Arg 
                405                 410                 


<210>  87
<211>  1992
<212>  DNA
<213>  Homo sapiens

<400>  87
cgcgcgccgg agcgcgctag ccgcattgcg agccgaaccc gggagctggc gccatggtgc       60

tgttgcacgt gctgtttgag cacgcggtcg gctacgcgct gctggcgctg aaggaagtgg      120

aggagatcag tctgctgcag ccgcaggtgg aggagtctgt gctcaacctg ggcaaattcc      180

acagcatcgt tcgtctggtg gccttttgtc cctttgcctc atcccaggtt gccttggaaa      240

atgccaacgc cgtgtctgaa ggggttgttc atgaggacct ccgcctgctc ttggagaccc      300

acctgccgtc caaaaagaag aaagtactct tgggagttgg ggatcccaag attggtgccg      360

caatacagga ggagttaggg tacaactgcc agactggagg agtcatagct gagatcctgc      420

gaggagttcg tctgcacttc cacaatctgg tgaagggtct gaccgatctg tcagcttgta      480

aagcacagct ggggctggga cacagctatt cccgtgccaa agttaagttt aatgtgaacc      540

gggtggacaa tatgatcatc cagtccatta gcctcctgga ccagctggat aaggacatca      600

ataccttctc tatgcgtgtc agggagtggt acgggtatca ctttccggag ctggtgaaga      660

tcatcaacga caatgccaca tactgccgtc ttgcccagtt tattggaaac cgaagggaac      720

tgaatgagga caagctggag aagctggagg agctgacaat ggatggggcc aaggctaagg      780

ctattctgga tgcctcacgg tcctccatgg gcatggacat atctgccatt gacttgataa      840

acatcgagag cttctccagt cgtgtggtgt ctttatctga ataccgccag agcctacaca      900

cttacctgcg ctccaagatg agccaagtag cccccagcct gtcagcccta attggggaag      960

cggtaggtgc acgtctcatc gcacatgctg gcagcctcac caacctggcc aagtatccag     1020

catccacagt gcagatcctt ggggctgaaa aggccctgtt cagagccctg aagacaaggg     1080

gtaacactcc aaaatatgga ctcattttcc actccacctt cattggccga gcagctgcca     1140

agaacaaagg ccgcatctcc cgatacctgg caaacaaatg cagtattgcc tcacgaatcg     1200

attgcttctc tgaggtgccc acgagtgtat tcggggagaa gcttcgagaa caagttgaag     1260

agcgactgtc cttctatgag actggagaga taccacgaaa gaatctggat gtcatgaagg     1320

aagcaatggt tcaggcagag gaagcggctg ctgagattac taggaagctg gagaaacagg     1380

agaagaaacg cttaaagaag gaaaagaaac ggctggctgc acttgccctc gcgtcttcag     1440

aaaacagcag tagtactcca gaggagtgtg aggagatgag tgaaaaaccc aaaaagaaga     1500

aaaagcaaaa gccccaggag gttcctcagg agaatggaat ggaagaccca tctatctctt     1560

tctccaaacc caagaaaaag aaatcttttt ccaaggagga gttgatgagt agcgatcttg     1620

aagagaccgc tggcagcacc agtattccca agaggaagaa gtctacaccc aaggaggaaa     1680

cagttaatga ccctgaggag gcaggccaca gaagtggctc caagaaaaag aggaaattct     1740

ccaaagagga gccggtcagc agtgggcctg aagaggcggt tggcaagagc agctccaaga     1800

agaagaaaaa gttccataaa gcatcccagg aagattagaa tgcaaatgga cattctctgg     1860

gaggtggggc ataccatagc ccaaggtgac atttcccacc ctgtgccgtg ttccccaata     1920

aaaacaaatt cacaagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aa                                                         1992


<210>  88
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Val Leu Leu His Val Leu Phe Glu His Ala Val Gly Tyr Ala Leu 
1               5                   10                  15      


Leu Ala Leu Lys Glu Val Glu Glu Ile Ser Leu Leu Gln Pro Gln Val 
            20                  25                  30          


Glu Glu Ser Val Leu Asn Leu Gly Lys Phe His Ser Ile Val Arg Leu 
        35                  40                  45              


Val Ala Phe Cys Pro Phe Ala Ser Ser Gln Val Ala Leu Glu Asn Ala 
    50                  55                  60                  


Asn Ala Val Ser Glu Gly Val Val His Glu Asp Leu Arg Leu Leu Leu 
65                  70                  75                  80  


Glu Thr His Leu Pro Ser Lys Lys Lys Lys Val Leu Leu Gly Val Gly 
                85                  90                  95      


Asp Pro Lys Ile Gly Ala Ala Ile Gln Glu Glu Leu Gly Tyr Asn Cys 
            100                 105                 110         


Gln Thr Gly Gly Val Ile Ala Glu Ile Leu Arg Gly Val Arg Leu His 
        115                 120                 125             


Phe His Asn Leu Val Lys Gly Leu Thr Asp Leu Ser Ala Cys Lys Ala 
    130                 135                 140                 


Gln Leu Gly Leu Gly His Ser Tyr Ser Arg Ala Lys Val Lys Phe Asn 
145                 150                 155                 160 


Val Asn Arg Val Asp Asn Met Ile Ile Gln Ser Ile Ser Leu Leu Asp 
                165                 170                 175     


Gln Leu Asp Lys Asp Ile Asn Thr Phe Ser Met Arg Val Arg Glu Trp 
            180                 185                 190         


Tyr Gly Tyr His Phe Pro Glu Leu Val Lys Ile Ile Asn Asp Asn Ala 
        195                 200                 205             


Thr Tyr Cys Arg Leu Ala Gln Phe Ile Gly Asn Arg Arg Glu Leu Asn 
    210                 215                 220                 


Glu Asp Lys Leu Glu Lys Leu Glu Glu Leu Thr Met Asp Gly Ala Lys 
225                 230                 235                 240 


Ala Lys Ala Ile Leu Asp Ala Ser Arg Ser Ser Met Gly Met Asp Ile 
                245                 250                 255     


Ser Ala Ile Asp Leu Ile Asn Ile Glu Ser Phe Ser Ser Arg Val Val 
            260                 265                 270         


Ser Leu Ser Glu Tyr Arg Gln Ser Leu His Thr Tyr Leu Arg Ser Lys 
        275                 280                 285             


Met Ser Gln Val Ala Pro Ser Leu Ser Ala Leu Ile Gly Glu Ala Val 
    290                 295                 300                 


Gly Ala Arg Leu Ile Ala His Ala Gly Ser Leu Thr Asn Leu Ala Lys 
305                 310                 315                 320 


Tyr Pro Ala Ser Thr Val Gln Ile Leu Gly Ala Glu Lys Ala Leu Phe 
                325                 330                 335     


Arg Ala Leu Lys Thr Arg Gly Asn Thr Pro Lys Tyr Gly Leu Ile Phe 
            340                 345                 350         


His Ser Thr Phe Ile Gly Arg Ala Ala Ala Lys Asn Lys Gly Arg Ile 
        355                 360                 365             


Ser Arg Tyr Leu Ala Asn Lys Cys Ser Ile Ala Ser Arg Ile Asp Cys 
    370                 375                 380                 


Phe Ser Glu Val Pro Thr Ser Val Phe Gly Glu Lys Leu Arg Glu Gln 
385                 390                 395                 400 


Val Glu Glu Arg Leu Ser Phe Tyr Glu Thr Gly Glu Ile Pro Arg Lys 
                405                 410                 415     


Asn Leu Asp Val Met Lys Glu Ala Met Val Gln Ala Glu Glu Ala Ala 
            420                 425                 430         


Ala Glu Ile Thr Arg Lys Leu Glu Lys Gln Glu Lys Lys Arg Leu Lys 
        435                 440                 445             


Lys Glu Lys Lys Arg Leu Ala Ala Leu Ala Leu Ala Ser Ser Glu Asn 
    450                 455                 460                 


Ser Ser Ser Thr Pro Glu Glu Cys Glu Glu Met Ser Glu Lys Pro Lys 
465                 470                 475                 480 


Lys Lys Lys Lys Gln Lys Pro Gln Glu Val Pro Gln Glu Asn Gly Met 
                485                 490                 495     


Glu Asp Pro Ser Ile Ser Phe Ser Lys Pro Lys Lys Lys Lys Ser Phe 
            500                 505                 510         


Ser Lys Glu Glu Leu Met Ser Ser Asp Leu Glu Glu Thr Ala Gly Ser 
        515                 520                 525             


Thr Ser Ile Pro Lys Arg Lys Lys Ser Thr Pro Lys Glu Glu Thr Val 
    530                 535                 540                 


Asn Asp Pro Glu Glu Ala Gly His Arg Ser Gly Ser Lys Lys Lys Arg 
545                 550                 555                 560 


Lys Phe Ser Lys Glu Glu Pro Val Ser Ser Gly Pro Glu Glu Ala Val 
                565                 570                 575     


Gly Lys Ser Ser Ser Lys Lys Lys Lys Lys Phe His Lys Ala Ser Gln 
            580                 585                 590         


Glu Asp 
        


<210>  89
<211>  2419
<212>  DNA
<213>  Homo sapiens

<400>  89
agttgattgc aggtcctcct ggggccagaa gggtgcctgg gaggccaggt tctggggatc       60

ccctccatcc agaagaacca cctgctcact ctgtcccttc gcctgctgct gggaccatgg      120

gggctggggc cagtgctgag gagaagcact ccagggagct ggaaaagaag ctgaaagagg      180

acgctgagaa ggatgctcga accgtgaagc tgctgcttct gggtgccggt gagtccggga      240

agagcaccat cgtcaagcag atgaagatta tccaccagga cgggtactcg ctggaagagt      300

gcctcgagtt tatcgccatc atctacggca acacgttgca gtccatcctg gccatcgtac      360

gcgccatgac cacactcaac atccagtacg gagactctgc acgccaggac gacgcccgga      420

agctgatgca catggcagac actatcgagg agggcacgat gcccaaggag atgtcggaca      480

tcatccagcg gctgtggaag gactccggta tccaggcctg ttttgagcgc gcctcggagt      540

accagctcaa cgactcggcg ggctactacc tctccgacct ggagcgcctg gtaaccccgg      600

gctacgtgcc caccgagcag gacgtgctgc gctcgcgagt caagaccact ggcatcatcg      660

agacgcagtt ctccttcaag gatctcaact tccggatgtt cgatgtgggc gggcagcgct      720

cggagcgcaa gaagtggatc cactgcttcg agggcgtgac ctgcatcatc ttcatcgcgg      780

cgctgagcgc ctacgacatg gtgctagtgg aggacgacga agtgaaccgc atgcacgaga      840

gcctgcacct gttcaacagc atctgcaacc accgctactt cgccacgacg tccatcgtgc      900

tcttccttaa caagaaggac gtcttcttcg agaagatcaa gaaggcgcac ctcagcatct      960

gtttcccgga ctacgatgga cccaacacct acgaggacgc cggcaactac atcaaggtgc     1020

agttcctcga gctcaacatg cggcgcgacg tgaaggagat ctattcccac atgacgtgcg     1080

ccaccgacac gcagaacgtc aaatttgtct tcgacgctgt caccgacatc atcatcaagg     1140

agaacctcaa agactgtggc ctcttctgag gtgcctgaat tcatgcgtgt cagtcaccct     1200

gagacctggt agccctagct gccttgcagc cccaaacccc aggaccctat cagccccctg     1260

ggactccctg gccccaacct gccacctcac caaagctctg agccctgcta gccttgaggc     1320

gcggaccctc ccccatacct cccacagtat cccagcgcct catgccccca accccaagcc     1380

ctgcccttca ccgcccggct gcactggcct ctaggactca cagcagccag ccccagctag     1440

gaacgggcag gacttggggc agctgaagct cacggtgact cagcagtgcc caactgacca     1500

atctcccgca gctctcctgc ccctgggggc ccacgactca cctggtgggc ctgggctcag     1560

caaacagccc tccctcccag tatttcatca aggacaggga atatccctcc cacacacagg     1620

ccagctgctc accctgccac ctccatgtga caagtttgac acctgtctac ccagagccag     1680

tgactgtccc tcccagcagc ctccaaaggg tccaaagtcc aagctagctc tggcctgtgt     1740

ggcccccaca taaataaatt agtggggagg gggcagacct gggggccctt gggtgccaga     1800

gtgagacaca gcaggaccct tccccaaata ctaggctcag agcaacctcc agccttctcc     1860

agcaggatct gctccctgtg tccttggaca gcagatccac acaccacttc cccacccaca     1920

cacagtaccc tgggctggtt ggacaacagg atggtgtgtt aaggggttaa gggagggtac     1980

tgttgacacc agctatggcc aatagctggg ctgtcctgag gggtggctgg ggacagagtc     2040

cagctccctt ggatcagccc agaggattca ggataggaca aaggccctgg ctgtgcccaa     2100

aagggtctac ctcaggtggg gttacaagca aacctgggtg accctcttgt ccctaccagc     2160

agcttctctt gccccttcca ttcagggttc cctggcaggg gaagctgaga gccatggctg     2220

aactatcagg gacaaaggcc catgtcccca catccctgct ccctccttcc tcatccagca     2280

ccaaatcttt gcttatgtcc acaggccagg gcctgtgctg cagtcgggga caaggagctt     2340

ccgtctggca aggccggggc acaatttgca ctcccctcag ctagacgcac agactcagca     2400

ataaaccttt gcatcaggc                                                  2419


<210>  90
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Ala Gly Ala Ser Ala Glu Glu Lys His Ser Arg Glu Leu Glu 
1               5                   10                  15      


Lys Lys Leu Lys Glu Asp Ala Glu Lys Asp Ala Arg Thr Val Lys Leu 
            20                  25                  30          


Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln 
        35                  40                  45              


Met Lys Ile Ile His Gln Asp Gly Tyr Ser Leu Glu Glu Cys Leu Glu 
    50                  55                  60                  


Phe Ile Ala Ile Ile Tyr Gly Asn Thr Leu Gln Ser Ile Leu Ala Ile 
65                  70                  75                  80  


Val Arg Ala Met Thr Thr Leu Asn Ile Gln Tyr Gly Asp Ser Ala Arg 
                85                  90                  95      


Gln Asp Asp Ala Arg Lys Leu Met His Met Ala Asp Thr Ile Glu Glu 
            100                 105                 110         


Gly Thr Met Pro Lys Glu Met Ser Asp Ile Ile Gln Arg Leu Trp Lys 
        115                 120                 125             


Asp Ser Gly Ile Gln Ala Cys Phe Glu Arg Ala Ser Glu Tyr Gln Leu 
    130                 135                 140                 


Asn Asp Ser Ala Gly Tyr Tyr Leu Ser Asp Leu Glu Arg Leu Val Thr 
145                 150                 155                 160 


Pro Gly Tyr Val Pro Thr Glu Gln Asp Val Leu Arg Ser Arg Val Lys 
                165                 170                 175     


Thr Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe Lys Asp Leu Asn Phe 
            180                 185                 190         


Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
        195                 200                 205             


His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Ile Ala Ala Leu Ser 
    210                 215                 220                 


Ala Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val Asn Arg Met His 
225                 230                 235                 240 


Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His Arg Tyr Phe Ala 
                245                 250                 255     


Thr Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp Val Phe Phe Glu 
            260                 265                 270         


Lys Ile Lys Lys Ala His Leu Ser Ile Cys Phe Pro Asp Tyr Asp Gly 
        275                 280                 285             


Pro Asn Thr Tyr Glu Asp Ala Gly Asn Tyr Ile Lys Val Gln Phe Leu 
    290                 295                 300                 


Glu Leu Asn Met Arg Arg Asp Val Lys Glu Ile Tyr Ser His Met Thr 
305                 310                 315                 320 


Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe Asp Ala Val Thr 
                325                 330                 335     


Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly Leu Phe 
            340                 345                 350 


<210>  91
<211>  2053
<212>  DNA
<213>  Homo sapiens

<400>  91
cacagccaca gccagggcta gcctcgccgg ttcccgggtg gcgcgcgttc gctgcctcct       60

cagctccagg atgatcggcc agaagacgct ctactccttt ttctccccca gccccgccag      120

gaagcgacac gcccccagcc ccgagccggc cgtccagggg accggcgtgg ctggggtgcc      180

tgaggaaagc ggagatgcgg cggccatccc agccaagaag gccccggctg ggcaggagga      240

gcctgggacg ccgccctcct cgccgctgag tgccgagcag ttggaccgga tccagaggaa      300

caaggccgcg gccctgctca gactcgcggc ccgcaacgtg cccgtgggct ttggagagag      360

ctggaagaag cacctcagcg gggagttcgg gaaaccgtat tttatcaagc taatgggatt      420

tgttgcagaa gaaagaaagc attacactgt ttatccaccc ccacaccaag tcttcacctg      480

gacccagatg tgtgacataa aagatgtgaa ggttgtcatc ctgggacagg atccatatca      540

tggacctaat caagctcacg ggctctgctt tagtgttcaa aggcctgttc cgcctccgcc      600

cagtttggag aacatttata aagagttgtc tacagacata gaggattttg ttcatcctgg      660

ccatggagat ttatctgggt gggccaagca aggtgttctc cttctcaacg ctgtcctcac      720

ggttcgtgcc catcaagcca actctcataa ggagcgaggc tgggagcagt tcactgatgc      780

agttgtgtcc tggctaaatc agaactcgaa tggccttgtt ttcttgctct ggggctctta      840

tgctcagaag aagggcagtg ccattgatag gaagcggcac catgtactac agacggctca      900

tccctcccct ttgtcagtgt atagagggtt ctttggatgt agacactttt caaagaccaa      960

tgagctgctg cagaagtctg gcaagaagcc cattgactgg aaggagctgt gatcatcagc     1020

tgaggggtgg cctttgagaa gctgctgtta acgtatttgc cagttacgaa gttccactga     1080

aaattttcct attaattctt aagtactctg cataaggggg aaaagcttcc agaaagcagc     1140

catgaaccag gctgtccagg aatggcagct gtatccaacc acaaacaaca aaggctaccc     1200

tttgaccaaa tgtctttctc tgcaacatgg cttcggccta aaatatgcag aagacagatg     1260

aggtcaaata ctcagttggc tctctttatc tcccttgcct ttatggtgaa acaggggaga     1320

tgtgcacctt tcaggcacag ccctagtttg gcgcctgctg ctccttggtt ttgcctggtt     1380

agactttcag tgacagatgt tggggtgttt ttgcttagaa aggtcccctt gtctcagcct     1440

tgcagggcag gcatgccagt ctctgccagt tccactgccc ccttgatctt tgaaggagtc     1500

ctcaggcccc tcgcagcata aggatgtttt gcaactttcc agaatctggc ccagaaatta     1560

gggctcaatt tcctgattgt agtagaggtt aagattgctg tgagctttat cagataagag     1620

accgagagaa gtaagctggg tcttgttatt ccttgggtgt tggtggaata agcagtggaa     1680

tttgaacaag gaagaggaga aaagggaatt ttgtctttat ggggtggggt gattttctcc     1740

tagggttatg tccagttggg gtttttaagg cagcacagac tgccaagtac tgtttttttt     1800

aaccgactga aatcactttg ggatattttt tcctgcaaca ctggaaagtt ttagtttttt     1860

aagaagtact catgcagata tatatatata tatttttccc agtccttttt ttaagagacg     1920

gtctttattg ggtctgcacc tccatccttg atcttgttag caatgctgtt tttgctgtta     1980

gtcgggttag agttggctct acgcgaggtt tgttaataaa agtttgttaa aagtttaaaa     2040

aaaaaaaaaa aaa                                                        2053


<210>  92
<211>  2081
<212>  DNA
<213>  Homo sapiens

<400>  92
tcgggaagcc atagggcgcc tcccagcccg tctccccgct ccagtttaga acctaattcc       60

caattcccgg accgggccca gccctgggct cttactgtcc gcttttgctg ggacctgttc      120

cacaaatggg cgtcttctgc cttgggccgt gggggttggg ccggaagctg cggacgcctg      180

ggaaggggcc gctgcagctc ttgagccgcc tctgcgggga ccacttgcag gccatcccag      240

ccaagaaggc cccggctggg caggaggagc ctgggacgcc gccctcctcg ccgctgagtg      300

ccgagcagtt ggaccggatc cagaggaaca aggccgcggc cctgctcaga ctcgcggccc      360

gcaacgtgcc cgtgggcttt ggagagagct ggaagaagca cctcagcggg gagttcggga      420

aaccgtattt tatcaagcta atgggatttg ttgcagaaga aagaaagcat tacactgttt      480

atccaccccc acaccaagtc ttcacctgga cccagatgtg tgacataaaa gatgtgaagg      540

ttgtcatcct gggacaggat ccatatcatg gacctaatca agctcacggg ctctgcttta      600

gtgttcaaag gcctgttccg cctccgccca gtttggagaa catttataaa gagttgtcta      660

cagacataga ggattttgtt catcctggcc atggagattt atctgggtgg gccaagcaag      720

gtgttctcct tctcaacgct gtcctcacgg ttcgtgccca tcaagccaac tctcataagg      780

agcgaggctg ggagcagttc actgatgcag ttgtgtcctg gctaaatcag aactcgaatg      840

gccttgtttt cttgctctgg ggctcttatg ctcagaagaa gggcagtgcc attgatagga      900

agcggcacca tgtactacag acggctcatc cctccccttt gtcagtgtat agagggttct      960

ttggatgtag acacttttca aagaccaatg agctgctgca gaagtctggc aagaagccca     1020

ttgactggaa ggagctgtga tcatcagctg aggggtggcc tttgagaagc tgctgttaac     1080

gtatttgcca gttacgaagt tccactgaaa attttcctat taattcttaa gtactctgca     1140

taagggggaa aagcttccag aaagcagcca tgaaccaggc tgtccaggaa tggcagctgt     1200

atccaaccac aaacaacaaa ggctaccctt tgaccaaatg tctttctctg caacatggct     1260

tcggcctaaa atatgcagaa gacagatgag gtcaaatact cagttggctc tctttatctc     1320

ccttgccttt atggtgaaac aggggagatg tgcacctttc aggcacagcc ctagtttggc     1380

gcctgctgct ccttggtttt gcctggttag actttcagtg acagatgttg gggtgttttt     1440

gcttagaaag gtccccttgt ctcagccttg cagggcaggc atgccagtct ctgccagttc     1500

cactgccccc ttgatctttg aaggagtcct caggcccctc gcagcataag gatgttttgc     1560

aactttccag aatctggccc agaaattagg gctcaatttc ctgattgtag tagaggttaa     1620

gattgctgtg agctttatca gataagagac cgagagaagt aagctgggtc ttgttattcc     1680

ttgggtgttg gtggaataag cagtggaatt tgaacaagga agaggagaaa agggaatttt     1740

gtctttatgg ggtggggtga ttttctccta gggttatgtc cagttggggt ttttaaggca     1800

gcacagactg ccaagtactg ttttttttaa ccgactgaaa tcactttggg atattttttc     1860

ctgcaacact ggaaagtttt agttttttaa gaagtactca tgcagatata tatatatata     1920

tttttcccag tccttttttt aagagacggt ctttattggg tctgcacctc catccttgat     1980

cttgttagca atgctgtttt tgctgttagt cgggttagag ttggctctac gcgaggtttg     2040

ttaataaaag tttgttaaaa gtttaaaaaa aaaaaaaaaa a                         2081


<210>  93
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ile Gly Gln Lys Thr Leu Tyr Ser Phe Phe Ser Pro Ser Pro Ala 
1               5                   10                  15      


Arg Lys Arg His Ala Pro Ser Pro Glu Pro Ala Val Gln Gly Thr Gly 
            20                  25                  30          


Val Ala Gly Val Pro Glu Glu Ser Gly Asp Ala Ala Ala Ile Pro Ala 
        35                  40                  45              


Lys Lys Ala Pro Ala Gly Gln Glu Glu Pro Gly Thr Pro Pro Ser Ser 
    50                  55                  60                  


Pro Leu Ser Ala Glu Gln Leu Asp Arg Ile Gln Arg Asn Lys Ala Ala 
65                  70                  75                  80  


Ala Leu Leu Arg Leu Ala Ala Arg Asn Val Pro Val Gly Phe Gly Glu 
                85                  90                  95      


Ser Trp Lys Lys His Leu Ser Gly Glu Phe Gly Lys Pro Tyr Phe Ile 
            100                 105                 110         


Lys Leu Met Gly Phe Val Ala Glu Glu Arg Lys His Tyr Thr Val Tyr 
        115                 120                 125             


Pro Pro Pro His Gln Val Phe Thr Trp Thr Gln Met Cys Asp Ile Lys 
    130                 135                 140                 


Asp Val Lys Val Val Ile Leu Gly Gln Asp Pro Tyr His Gly Pro Asn 
145                 150                 155                 160 


Gln Ala His Gly Leu Cys Phe Ser Val Gln Arg Pro Val Pro Pro Pro 
                165                 170                 175     


Pro Ser Leu Glu Asn Ile Tyr Lys Glu Leu Ser Thr Asp Ile Glu Asp 
            180                 185                 190         


Phe Val His Pro Gly His Gly Asp Leu Ser Gly Trp Ala Lys Gln Gly 
        195                 200                 205             


Val Leu Leu Leu Asn Ala Val Leu Thr Val Arg Ala His Gln Ala Asn 
    210                 215                 220                 


Ser His Lys Glu Arg Gly Trp Glu Gln Phe Thr Asp Ala Val Val Ser 
225                 230                 235                 240 


Trp Leu Asn Gln Asn Ser Asn Gly Leu Val Phe Leu Leu Trp Gly Ser 
                245                 250                 255     


Tyr Ala Gln Lys Lys Gly Ser Ala Ile Asp Arg Lys Arg His His Val 
            260                 265                 270         


Leu Gln Thr Ala His Pro Ser Pro Leu Ser Val Tyr Arg Gly Phe Phe 
        275                 280                 285             


Gly Cys Arg His Phe Ser Lys Thr Asn Glu Leu Leu Gln Lys Ser Gly 
    290                 295                 300                 


Lys Lys Pro Ile Asp Trp Lys Glu Leu 
305                 310             


<210>  94
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Gly Val Phe Cys Leu Gly Pro Trp Gly Leu Gly Arg Lys Leu Arg 
1               5                   10                  15      


Thr Pro Gly Lys Gly Pro Leu Gln Leu Leu Ser Arg Leu Cys Gly Asp 
            20                  25                  30          


His Leu Gln Ala Ile Pro Ala Lys Lys Ala Pro Ala Gly Gln Glu Glu 
        35                  40                  45              


Pro Gly Thr Pro Pro Ser Ser Pro Leu Ser Ala Glu Gln Leu Asp Arg 
    50                  55                  60                  


Ile Gln Arg Asn Lys Ala Ala Ala Leu Leu Arg Leu Ala Ala Arg Asn 
65                  70                  75                  80  


Val Pro Val Gly Phe Gly Glu Ser Trp Lys Lys His Leu Ser Gly Glu 
                85                  90                  95      


Phe Gly Lys Pro Tyr Phe Ile Lys Leu Met Gly Phe Val Ala Glu Glu 
            100                 105                 110         


Arg Lys His Tyr Thr Val Tyr Pro Pro Pro His Gln Val Phe Thr Trp 
        115                 120                 125             


Thr Gln Met Cys Asp Ile Lys Asp Val Lys Val Val Ile Leu Gly Gln 
    130                 135                 140                 


Asp Pro Tyr His Gly Pro Asn Gln Ala His Gly Leu Cys Phe Ser Val 
145                 150                 155                 160 


Gln Arg Pro Val Pro Pro Pro Pro Ser Leu Glu Asn Ile Tyr Lys Glu 
                165                 170                 175     


Leu Ser Thr Asp Ile Glu Asp Phe Val His Pro Gly His Gly Asp Leu 
            180                 185                 190         


Ser Gly Trp Ala Lys Gln Gly Val Leu Leu Leu Asn Ala Val Leu Thr 
        195                 200                 205             


Val Arg Ala His Gln Ala Asn Ser His Lys Glu Arg Gly Trp Glu Gln 
    210                 215                 220                 


Phe Thr Asp Ala Val Val Ser Trp Leu Asn Gln Asn Ser Asn Gly Leu 
225                 230                 235                 240 


Val Phe Leu Leu Trp Gly Ser Tyr Ala Gln Lys Lys Gly Ser Ala Ile 
                245                 250                 255     


Asp Arg Lys Arg His His Val Leu Gln Thr Ala His Pro Ser Pro Leu 
            260                 265                 270         


Ser Val Tyr Arg Gly Phe Phe Gly Cys Arg His Phe Ser Lys Thr Asn 
        275                 280                 285             


Glu Leu Leu Gln Lys Ser Gly Lys Lys Pro Ile Asp Trp Lys Glu Leu 
    290                 295                 300                 


<210>  95
<211>  1478
<212>  DNA
<213>  Homo sapiens

<400>  95
gccacgggct cagtcttcct ctcccgaaaa aggagaccta ccgtacttgt tttttttttt       60

ctcctgcacg tgaagggcga gttccacttg ctgatcgaat aaagtcagag atccagaaat      120

tccagtgtca attaagtgga aagatggacc ctcattctat ctgcttggga aacagtcctt      180

attaatagca acactgacag aacctgaggt ttggagatgt actaatggct ttcagcctgt      240

gttggaaagc tcccaggagc ccatggagtt tcctgcaggc tgtgaacaat gggtctcccc      300

tgtttctctg gaggacagtg gggagctgtt tggatcctaa gatgaaagcc tacctggaag      360

agaacactga agtcaccagc agtggtagcc ttaccccgga aatccagtta cggcttttaa      420

cccccaggtg caagttttgg tgggaaaggg ctgacctgtg gccctacagt gatccctact      480

gggctattta ctggccagga ggccaggctc tgtctaggta tcttttggat aaccctgctg      540

ttgttagagg aaagtctgtc ttagatcttg ggagtggatg tggagctaca gccattgctg      600

ccaagatgag tggagcatca aagatcttgg ccaacgacat agaccccatt gcaggaatgg      660

cgattacact aaattgcaaa ttaaatggac tgaatccttt tcctgtttta actaaaaaca      720

ttttgaatac ccaacaaggt aagtttgatc tcattgttct tggagatatg ttttatgatg      780

aagaccttgc agacagtctt catctgtggc tgcagaacta cttttggacc catggaaccc      840

gagtactgat tggtgaccct gggaggcccc agttcagtgg acatagcatt cggcatcaac      900

tgtaccaact agtagaatac acacttccag agccaactca gcaagagaac aatggactga      960

ccacaagtgc tgtatgggat tttcatccct gatttgttaa agtgctttca agtatgaata     1020

tagttctgtt tgtgttaagt tctaaaaata tcctctgtag gaggtattca acagtttaaa     1080

gaatgcaatt cagtggcttg tggtggattg ggccttgaat actaccactt gggaggctga     1140

agtaggcgca tctctgtgac tttgaggaca gcttggtcta tagtgagttc aaggacagcc     1200

agagctatat agtaagaccc tgttccaaaa atagatagat agataataaa gtaaatttct     1260

tcattccttt gctgtgacac cttgaataac tgtatggttt attaaagtta gttatggtta     1320

tgttcccatt tcacatacca aggtgtcagg attttataac aaagcactct atcatataca     1380

attgcatatg tagaaggtat atttatatat gtatgtatgt atggatgtaa tatatataat     1440

ttgcttcagt attaataaaa tatctctgga aagataaa                             1478


<210>  96
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Phe Ser Leu Cys Trp Lys Ala Pro Arg Ser Pro Trp Ser Phe 
1               5                   10                  15      


Leu Gln Ala Val Asn Asn Gly Ser Pro Leu Phe Leu Trp Arg Thr Val 
            20                  25                  30          


Gly Ser Cys Leu Asp Pro Lys Met Lys Ala Tyr Leu Glu Glu Asn Thr 
        35                  40                  45              


Glu Val Thr Ser Ser Gly Ser Leu Thr Pro Glu Ile Gln Leu Arg Leu 
    50                  55                  60                  


Leu Thr Pro Arg Cys Lys Phe Trp Trp Glu Arg Ala Asp Leu Trp Pro 
65                  70                  75                  80  


Tyr Ser Asp Pro Tyr Trp Ala Ile Tyr Trp Pro Gly Gly Gln Ala Leu 
                85                  90                  95      


Ser Arg Tyr Leu Leu Asp Asn Pro Ala Val Val Arg Gly Lys Ser Val 
            100                 105                 110         


Leu Asp Leu Gly Ser Gly Cys Gly Ala Thr Ala Ile Ala Ala Lys Met 
        115                 120                 125             


Ser Gly Ala Ser Lys Ile Leu Ala Asn Asp Ile Asp Pro Ile Ala Gly 
    130                 135                 140                 


Met Ala Ile Thr Leu Asn Cys Lys Leu Asn Gly Leu Asn Pro Phe Pro 
145                 150                 155                 160 


Val Leu Thr Lys Asn Ile Leu Asn Thr Gln Gln Gly Lys Phe Asp Leu 
                165                 170                 175     


Ile Val Leu Gly Asp Met Phe Tyr Asp Glu Asp Leu Ala Asp Ser Leu 
            180                 185                 190         


His Leu Trp Leu Gln Asn Tyr Phe Trp Thr His Gly Thr Arg Val Leu 
        195                 200                 205             


Ile Gly Asp Pro Gly Arg Pro Gln Phe Ser Gly His Ser Ile Arg His 
    210                 215                 220                 


Gln Leu Tyr Gln Leu Val Glu Tyr Thr Leu Pro Glu Pro Thr Gln Gln 
225                 230                 235                 240 


Glu Asn Asn Gly Leu Thr Thr Ser Ala Val Trp Asp Phe His Pro 
                245                 250                 255 


<210>  97
<211>  1837
<212>  DNA
<213>  Homo sapiens

<400>  97
aaagggcgcc acgagtcggc attgtcaggc ggcggcaccg cgcgggacgg agcttggctg       60

ttggtcggtg ggttcccgtg cggcggcggc caaggaggag gagacacagt tggagcagct      120

ccgtgggctg actggggcga ggcctcagca gcgcgagctt gagtgcggcc gagcctgcgg      180

cgccttcccc tgcgggtggg gacgagcggg ccccgcggcg tcatcggcgg cgaggagccg      240

ccgcgcctcg gcctagcatg tcggaagcgg gcgaggagca gcccatggag acgacgggcg      300

ccaccgagaa cggacatgag gccgtccccg aaggcgagtc gccggccggg gctggcacgg      360

gcgccgcggc gggggctgga ggcgcgaccg cggcgccccc gagcgggaat cagaacggcg      420

ccgagggcga ccagatcaac gccagcaaga acgaggagga cgcgggaaaa atgttcgttg      480

gtggcctgag ctgggatact agcaaaaaag atttaaaaga ctattttact aaatttggag      540

aggtcgttga ctgtacaata aaaatggatc ccaacactgg acggtcaaga gggtttgggt      600

ttatcctgtt caaagatgca gccagtgtgg agaaggtcct agaccagaag gagcacaggc      660

tggatggccg tgtcattgac cctaaaaagg ccatggctat gaagaaggac ccggtgaaga      720

aaatcttcgt tgggggtctg aatcctgaag ccactgagga aaagatcagg gagtactttg      780

gcgagtttgg ggagattgag gccattgaat tgccaatgga tccaaagttg aacaaaagac      840

gaggttttgt gtttatcacc tttaaagaag aagaacccgt gaagaaggtt ctggagaaaa      900

agttccatac tgtcagtgga agcaagtgtg agatcaaggt ggcccagccc aaagaagtct      960

atcagcagca gcagtatggc tctgggggcc gtggaaaccg caaccgaggg aaccgaggca     1020

gcggaggtgg tggtggaggt ggaggtcaga gtcagagttg gaatcagggc tacggcaact     1080

actggaacca gggctacggc taccagcagg gctacgggcc tggctatggc ggctacgact     1140

actcgcccta tggctattac ggctacggcc ccggctacga ctacagtcag ggtagtacaa     1200

actacggcaa gagccagcga cgtggtggcc atcagaataa ctacaagcca tactgaggcg     1260

gcagcaggag cgaccaactg atcgcacaca tgctttgttt ggatatggag tgaacacaat     1320

tatgtaccaa atttaacttg gcaaactttc tattgcctgt cccatgtgca tcttatttaa     1380

aatttccccc atggaaatca ctctcctgtt gactatttcc agagctctag gtgtttaggc     1440

agcgtgtggt gtctgagagg ccatagcgcc atcatgggct gatttttatt accaggtccc     1500

ccagaagcag gtgggaggct ctgcttcctg ctgccgctct gcagcctgga cctgtggacc     1560

ctggttgtaa agagtaaatt gtatcttagg aaaccagtgt cacctttttt tcacctttta     1620

attttatatt atttgcgtca tacatttcct gtaacggaag tgttaatttt actgtacttt     1680

ttggtacctt ttgggaatct aatgtattgt aaggtatttt acacgtgtcc tgattttgcc     1740

acaacctgga tattgaagct atccaagctt ttgaaataaa atttaaaaac ccccaagcct     1800

gggtgagtgt gggataaaaa aaaaaaaaaa aaaaaaa                              1837


<210>  98
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala 
            20                  25                  30          


Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro 
        35                  40                  45              


Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys 
    50                  55                  60                  


Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp 
65                  70                  75                  80  


Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val 
                85                  90                  95      


Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly 
            100                 105                 110         


Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu 
        115                 120                 125             


Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys 
    130                 135                 140                 


Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly 
145                 150                 155                 160 


Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Ser Gln Ser Trp Asn Gln Gly Tyr 
            260                 265                 270         


Gly Asn Tyr Trp Asn Gln Gly Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro 
        275                 280                 285             


Gly Tyr Gly Gly Tyr Asp Tyr Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly 
    290                 295                 300                 


Pro Gly Tyr Asp Tyr Ser Gln Gly Ser Thr Asn Tyr Gly Lys Ser Gln 
305                 310                 315                 320 


Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
                325                 330         


<210>  99
<211>  1218
<212>  DNA
<213>  Homo sapiens

<400>  99
aaaggtctag gatgacatct ggtgtattga ctgtggccag tcttaaagct agtttttgct       60

atgtggaaca tgctgctcta attcagattt aaagagtttc ttcctgttaa ttcgaagctc      120

actgtgcctc ttgtttccga gggaagaagg actgattaag tcatctaaat ggatgcaata      180

ctgaattaca ggtcagaaga tactgaagat tactacacat tactgggatg tgatgaacta      240

tcttcggttg aacaaatcct ggcagaattt aaagtcagag ctctggaatg tcacccagac      300

aagcatcctg aaaaccccaa agctgtggag acttttcaga aactgcagaa ggcaaaggag      360

attctgacca atgaagagag tcgagcccgc tatgaccact ggcgaaggag ccagatgtcg      420

atgccattcc agcagtggga agctttgaat gactcagtga agacgtcaat gcactgggtt      480

gtcagaggta aaaaagacct gatgctggaa gaatctgaca agactcatac caccaagatg      540

gaaaatgagg aatgtaatga gcaaagagaa agaaagaaag aggagctggc ttcaaccgca      600

gagaaaacgg agcagaaaga acccaagccc ctagagaagt cagtctcccc gcaaaattca      660

gattcttcag gttttgcaga tgtgaatggt tggcaccttc gtttccgctg gtccaaggat      720

gctccctcag aactcctgag gaagttcaga aactatgaaa tatgaaatat ctctgcttca      780

aaaaatgagg aagagcaaga ctgtccccta tgctgccaac atgcagtctt tgtttatgtc      840

ttaaaaatgt catgtttatg tcatgtctgt gaattgctga gtactaattg attcctccat      900

ccttgaatca gttctcataa tgctttttaa ataagaaaaa ttcagaagat gaatttcttc      960

caatatttga ataaattaaa gctcttagat acagagtaga ttgtattata tgctttttcc     1020

tattaatact acttatagaa atccattaaa aagcaatctc tgtacagtgt atttaaatat     1080

ttcattgaca tactgtgatc tctattagtg atggatgtac aaaaaatgtt ttcttaccct     1140

tgacttacaa tgaaatgtga aattacttgt ctgaaccccg tggggagaaa taaataattt     1200

tcccaaagtt caaaaaaa                                                   1218


<210>  100
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Asp Ala Ile Leu Asn Tyr Arg Ser Glu Asp Thr Glu Asp Tyr Tyr 
1               5                   10                  15      


Thr Leu Leu Gly Cys Asp Glu Leu Ser Ser Val Glu Gln Ile Leu Ala 
            20                  25                  30          


Glu Phe Lys Val Arg Ala Leu Glu Cys His Pro Asp Lys His Pro Glu 
        35                  40                  45              


Asn Pro Lys Ala Val Glu Thr Phe Gln Lys Leu Gln Lys Ala Lys Glu 
    50                  55                  60                  


Ile Leu Thr Asn Glu Glu Ser Arg Ala Arg Tyr Asp His Trp Arg Arg 
65                  70                  75                  80  


Ser Gln Met Ser Met Pro Phe Gln Gln Trp Glu Ala Leu Asn Asp Ser 
                85                  90                  95      


Val Lys Thr Ser Met His Trp Val Val Arg Gly Lys Lys Asp Leu Met 
            100                 105                 110         


Leu Glu Glu Ser Asp Lys Thr His Thr Thr Lys Met Glu Asn Glu Glu 
        115                 120                 125             


Cys Asn Glu Gln Arg Glu Arg Lys Lys Glu Glu Leu Ala Ser Thr Ala 
    130                 135                 140                 


Glu Lys Thr Glu Gln Lys Glu Pro Lys Pro Leu Glu Lys Ser Val Ser 
145                 150                 155                 160 


Pro Gln Asn Ser Asp Ser Ser Gly Phe Ala Asp Val Asn Gly Trp His 
                165                 170                 175     


Leu Arg Phe Arg Trp Ser Lys Asp Ala Pro Ser Glu Leu Leu Arg Lys 
            180                 185                 190         


Phe Arg Asn Tyr Glu Ile 
        195             


<210>  101
<211>  2122
<212>  DNA
<213>  Homo sapiens

<400>  101
gcgacgcagc tgttcacgct taggtgggcg caggtaggcg cgtggggcgg cggcggggtg       60

gccggcgggt cagggcgcca ggagacccag agccccgggg cgggctcccg cggggctccg      120

ccccctccac gtgggtgcgc ggaggcccgg cgcggcgcga ccgggcggcg gccctggggt      180

ccgcggtgct ggggaggctg ctgcggccgg tgcgtcccgg cgcgggctcc gacacccgca      240

cccgcctctg ggttaactca gcgcgggcga gtggaaggga ctcagctggc tcctatgttt      300

caggccgtca gggcttgcag tggctctggt ttcattgtct ttctctgaag acgccctgat      360

tgccctccga ggctttcagc tcccactttc tcttttttaa tttttgaggc agtgtctcgc      420

tgtgccaccc aggctggagt gcaatggcgt gatcatagct cactgcagcc tccacctcct      480

gggctcaagc cgtcctcccg cctcatcctc ccaagtagct gggaccacat gcgcgcgcca      540

ccacacccgg ataattttta aaaatgtttt ttgtagaaat ggggtctcac catgttaccc      600

aggctggtct cgaattcttg ggctcaagcg atggatcctc ctgcctcggc ctcccaaagt      660

gctgggatta caggagtgag ccaacgcgct tggcctcact ttccatcata agcatgcttt      720

ccgtttcctt ccttccgtca ttcattcatt catttttaaa aaacgttcat tgggttcctc      780

ctgcactgtt cggggcattg ggctacagct gtcaacaagt ggagacaagt ctgtgatctt      840

gtgaacttcc attctggagg ggagagacag atgaacaagg tgcacagagc aggtgatgga      900

tggcaaaaca gaagagaaaa gttcctgaag tgacagagaa aaagaacaaa aagctgaaga      960

aggcgtcagc agaggggcca ctgctgggcc ctgaggctgc accaagtggc gaaggagccg     1020

gctccaaggg cgaagctgtg ctcaggcccg ggctggacgc agagccagag ctgtccccag     1080

aggagcagag ggtcctggaa aggaagctga aaaaggaacg gaagaaagag gagaggcagc     1140

gtctgcggga ggcaggcctt gtggcccagc acccgcctgc caggcgctcg ggggccgaac     1200

tggccctgga ctacctctgc agatgggccc aaaagcacaa gaactggagg tttcagaaga     1260

cgaggcagac gtggctcctg ctgcacatgt atgacagtga caaggttccc gatgagcact     1320

tctccaccct gctggcctac ctggaggggc tgcagggccg ggcccgagag ctgacggtgc     1380

agaaggcgga agccctgatg cgggagctgg atgaggaggg ctctgatccc cccctgccgg     1440

ggagggccca gcgcatccga caggtgctgc agctgctctc ctagtgggtt cagcgcgggg     1500

cggggccgct gcccagtgca gggctgcctc agaccacaca gggtgcagct cctccggcgg     1560

tgggggccgg gttcaccagc agggcagcgg ctgagcaagg gctttcagct cctccggtgg     1620

tgggggccgg gatcaccagc accagagcct cgcaagggcc ccttccctcc tccagaccct     1680

ccttggccgg tgacggctgt gacagtgatg gcaggttcag tgccttcagc gcagagcgtg     1740

gatgctctgg aatcacccgg acccctggcc ttggagggac cctccagccc caggaatctg     1800

ctttggaggg aaatgtctat ttttctaccg ggaatatttt agagattggg gcatgctggc     1860

tcctcccgcc agctgcaaac ctgcaccttc cgcctgattc ccgatccccc tgcgtgggct     1920

gcattcctgg tcccctgcct gcgtccatcg aggggcctgg ctgtggcctg ttttcctttg     1980

accccacaca gcgtcattgc gggtcatggg gagcccctgg tgggagcttg tggagtcgga     2040

tcacgtacct gtgcagaaac cgcctctgtg gctgcatttg aaataaaacc cgacccagca     2100

gcaaaaaaaa aaaaaaaaaa aa                                              2122


<210>  102
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Lys Gln Lys Arg Lys Val Pro Glu Val Thr Glu Lys Lys Asn 
1               5                   10                  15      


Lys Lys Leu Lys Lys Ala Ser Ala Glu Gly Pro Leu Leu Gly Pro Glu 
            20                  25                  30          


Ala Ala Pro Ser Gly Glu Gly Ala Gly Ser Lys Gly Glu Ala Val Leu 
        35                  40                  45              


Arg Pro Gly Leu Asp Ala Glu Pro Glu Leu Ser Pro Glu Glu Gln Arg 
    50                  55                  60                  


Val Leu Glu Arg Lys Leu Lys Lys Glu Arg Lys Lys Glu Glu Arg Gln 
65                  70                  75                  80  


Arg Leu Arg Glu Ala Gly Leu Val Ala Gln His Pro Pro Ala Arg Arg 
                85                  90                  95      


Ser Gly Ala Glu Leu Ala Leu Asp Tyr Leu Cys Arg Trp Ala Gln Lys 
            100                 105                 110         


His Lys Asn Trp Arg Phe Gln Lys Thr Arg Gln Thr Trp Leu Leu Leu 
        115                 120                 125             


His Met Tyr Asp Ser Asp Lys Val Pro Asp Glu His Phe Ser Thr Leu 
    130                 135                 140                 


Leu Ala Tyr Leu Glu Gly Leu Gln Gly Arg Ala Arg Glu Leu Thr Val 
145                 150                 155                 160 


Gln Lys Ala Glu Ala Leu Met Arg Glu Leu Asp Glu Glu Gly Ser Asp 
                165                 170                 175     


Pro Pro Leu Pro Gly Arg Ala Gln Arg Ile Arg Gln Val Leu Gln Leu 
            180                 185                 190         


Leu Ser 
        


<210>  103
<211>  24
<212>  DNA
<213>  synthetic

<400>  103
ttgttccagg ctcagagggc acta                                              24


<210>  104
<211>  23
<212>  DNA
<213>  synthetic

<400>  104
atcaactggg aggcgctatg gag                                               23


<210>  105
<211>  24
<212>  DNA
<213>  synthetic

<400>  105
atatctcgca cctttagcca ttct                                              24


<210>  106
<211>  21
<212>  DNA
<213>  synthetic

<400>  106
ctcagttcca gcatcttctc a                                                 21


<210>  107
<211>  24
<212>  DNA
<213>  synthetic

<400>  107
ttcggggaaa ctaggaccat agca                                              24


<210>  108
<211>  22
<212>  DNA
<213>  synthetic

<400>  108
agtgcggcac catgttctca cg                                                22


<210>  109
<211>  20
<212>  DNA
<213>  synthetic

<400>  109
cctctggtcg taccacaggc                                                   20


<210>  110
<211>  22
<212>  DNA
<213>  synthetic

<400>  110
acggatgtca acgtcacact tc                                                22


<210>  111
<211>  1878
<212>  DNA
<213>  Mus musculus

<400>  111
gagcgggctg gttagcagcg cacgtgccag gctccggggc ccttctgctt atacacaatt       60

tctttctgtc ctgggtttct tcgtccctga gacccactcc atcttctact tctttggctc      120

tcgcccagct ccctacccca agctctgtaa ctcgtcgtct gcaaaatcga aatggacaca      180

tccatgaatt tctcacgcgg gttaaaaatg gacctgatgc aaccctatga cttcgagacg      240

tttcaggact taaggccctt tttggaggag tactgggtaa gctcatttct catagtggtc      300

gtctatctgt tgctcatcgt tgttggccag acctacatga gaacgcggaa gagcttcagc      360

ttgcagaggc ctctcatcct ctggtccttc ttcctggcaa tattcagtat cctgggtact      420

ctgaggatgt ggaagtttat ggcaacagtg atgtttacag tgggcctcaa gcaaaccgtg      480

tgctttgcca tctacacgga tgacgccgta gtcagattct ggtcctttct ctttcttctc      540

agcaaggttg ttgaactggg agacacggcc ttcatcatcc tgcgtaagcg tccactcatc      600

tttgtccact ggtaccacca cagcacagtg ctactgttca caagctttgg atacaagaac      660

aaagtgcctt cgggtggctg gttcatgacc atgaactttg gcgtccattc tgtcatgtac      720

acttactaca ctatgaaggc tgccaaactg aagcatccta atcttctccc catggtcatc      780

accagcctgc agattctgca gatggttctg ggcaccatct ttggcatact gaattacatc      840

tggaggcagg agaaaggatg ccacacaaca acggaacact tcttctggtc ttttatgcta      900

tatgggacct atttcatcct attcgctcac ttcttccacc gagcctacct caggcccaag      960

ggcaaagttg catccaagag ccaatgagag taggaaagaa agatggagcc tcagccgttc     1020

ctccgtggca ctaagggtat gggagaatga ttagggtacc tccctgtatg gtttccccca     1080

tgggatatgt accctcaaag ttgcaggaag ctatgacaac caagaaatgt cacccttggg     1140

gatagggggt gtgtggtttg gtactttgat gtttctgtct ttaatgtgaa ggaaaaccaa     1200

gccctaggaa ggagatagga ctgaggtcct taaaatggag ttatttatat ttatatttag     1260

aaatctttct cttcttgctc tatttttaaa agaggtcaac atgatcttga ggatttgtgg     1320

acttggaggg gaggggagag tggactgact ctgtggtagg aggaggctga ctctggggag     1380

tgagtgatct gcaggggggg agcctgaggg tgtgtggaag gacagaggca cacacaaaca     1440

ctcaataaga attctaggcc tggtaggcgc ttaataaatg tcttttacag actagaagtt     1500

tattgctgtt agagacccaa gcctctgaaa ggaacagtga gaaacaagtc ctaaatcata     1560

ggctaaactg cagaagagat cgctgcgtgg aagcacgggt gaccagacct accggctgtc     1620

ctcccagaga ccaccaggtg gcgtcgcagc accagcagag aacgatccct gtcagctagc     1680

tggtcacacc aagcttcata ctccttttac tccaggagac cctgcttccc tatcctggag     1740

gaaaggagtg agacggcaac cttagaagcc tggacgctca ctcggttcct gtacatccag     1800

ctgtcctttt ggacaatggg aaggatgaag ggaaggaggg ctcaaccgca agtctgaatc     1860

atcaggcctt tgacagtc                                                   1878


<210>  112
<211>  271
<212>  PRT
<213>  Mus musculus

<400>  112

Met Asp Thr Ser Met Asn Phe Ser Arg Gly Leu Lys Met Asp Leu Met 
1               5                   10                  15      


Gln Pro Tyr Asp Phe Glu Thr Phe Gln Asp Leu Arg Pro Phe Leu Glu 
            20                  25                  30          


Glu Tyr Trp Val Ser Ser Phe Leu Ile Val Val Val Tyr Leu Leu Leu 
        35                  40                  45              


Ile Val Val Gly Gln Thr Tyr Met Arg Thr Arg Lys Ser Phe Ser Leu 
    50                  55                  60                  


Gln Arg Pro Leu Ile Leu Trp Ser Phe Phe Leu Ala Ile Phe Ser Ile 
65                  70                  75                  80  


Leu Gly Thr Leu Arg Met Trp Lys Phe Met Ala Thr Val Met Phe Thr 
                85                  90                  95      


Val Gly Leu Lys Gln Thr Val Cys Phe Ala Ile Tyr Thr Asp Asp Ala 
            100                 105                 110         


Val Val Arg Phe Trp Ser Phe Leu Phe Leu Leu Ser Lys Val Val Glu 
        115                 120                 125             


Leu Gly Asp Thr Ala Phe Ile Ile Leu Arg Lys Arg Pro Leu Ile Phe 
    130                 135                 140                 


Val His Trp Tyr His His Ser Thr Val Leu Leu Phe Thr Ser Phe Gly 
145                 150                 155                 160 


Tyr Lys Asn Lys Val Pro Ser Gly Gly Trp Phe Met Thr Met Asn Phe 
                165                 170                 175     


Gly Val His Ser Val Met Tyr Thr Tyr Tyr Thr Met Lys Ala Ala Lys 
            180                 185                 190         


Leu Lys His Pro Asn Leu Leu Pro Met Val Ile Thr Ser Leu Gln Ile 
        195                 200                 205             


Leu Gln Met Val Leu Gly Thr Ile Phe Gly Ile Leu Asn Tyr Ile Trp 
    210                 215                 220                 


Arg Gln Glu Lys Gly Cys His Thr Thr Thr Glu His Phe Phe Trp Ser 
225                 230                 235                 240 


Phe Met Leu Tyr Gly Thr Tyr Phe Ile Leu Phe Ala His Phe Phe His 
                245                 250                 255     


Arg Ala Tyr Leu Arg Pro Lys Gly Lys Val Ala Ser Lys Ser Gln 
            260                 265                 270     


<210>  113
<211>  4405
<212>  DNA
<213>  Mus musculus

<400>  113
gtggtcatcc actttctaca gagaacacgt ctatgaaata gtatcaggag acacacggag       60

ccatcaaaat catcaagctt tggaatgggt ggacacagaa tggttcttct tggaggtgct      120

ggatctcctg gttgtaaaag gtttgtccat ctaggtttct ttgttgtggc tgtgagctca      180

cttctcagtg cctctgctgt cactaacgct cctggagaaa tgaagaagga actgagactg      240

gcgggtggtg aaaacaactg tagtgggaga gtggaactta agatccatga caagtggggc      300

acagtgtgca gtaacggctg gagcatgaat gaagtgtccg tggtttgcca gcagctggga      360

tgcccaactt ctattaaagc ccttggatgg gctaactcca gcgccggctc tggatatatc      420

tggatggaca aagtttcttg tacagggaat gagtcagctc tttgggactg caaacatgat      480

gggtggggaa agcataactg tacccatgaa aaagatgctg gagtgacctg ctcagatgga      540

tctaatttgg agatgagact ggtgaacagt gcgggccacc gatgcttagg aagagtagaa      600

ataaagttcc agggaaagtg ggggacggtg tgtgacgaca acttcagcaa agatcacgct      660

tctgtgattt gtaaacagct tggatgtgga agtgccatta gtttctctgg ctcagctaaa      720

ttgggagctg gttctggacc aatctggctc gatgacctgg catgcaatgg aaatgagtca      780

gctctctggg actgcaaaca ccggggatgg ggcaagcata actgtgacca tgctgaggat      840

gtcggtgtga tttgcttaga gggagcagat ctgagcctga gactagtgga tggagtgtcc      900

agatgttcag gaagattgga agtgagattc caaggagaat gggggaccgt gtgtgatgat      960

aactgggatc tccgggatgc ttctgtggtg tgcaagcaac tgggatgtcc aactgccatc     1020

agtgccattg gtcgagttaa tgccagtgag ggatctggac agatttggct tgacaacatt     1080

tcatgcgaag gacatgaggc aactctttgg gagtgtaaac accaagagtg gggaaagcat     1140

tactgtcatc atagagaaga cgctggtgtg acatgttctg atggagcaga tctggaactt     1200

agacttgtag gtggaggcag tcgctgtgct ggcattgtgg aggtggagat tcagaagctg     1260

actgggaaga tgtgtagccg aggctggaca ctggcagatg cggatgtggt ttgcagacag     1320

cttggatgtg gatctgcgct tcaaacccag gctaagatct actctaaaac tggggcaaca     1380

aatacgtggc tctttcctgg atcttgtaat ggaaatgaaa ctactttttg gcaatgcaaa     1440

aactggcagt ggggcggcct ttcctgtgat aatttcgaag aagccaaagt tacctgctca     1500

ggccacaggg aacccagact ggttggagga gaaatcccat gctctggtcg tgtggaagtg     1560

aaacacggag acgtgtgggg ctccgtctgt gattttgact tgtctctgga agctgccagt     1620

gtggtgtgca gggaattaca atgtggaaca gtcgtctcta tcctaggggg agcacatttt     1680

ggagaaggaa gtggacagat ctggggtgaa gaattccagt gtagtgggga tgagtcccat     1740

ctttcactat gctcagtggc gcccccgcta gacagaactt gtacccacag cagggatgtc     1800

agcgtagtct gctcacgata catagatatt cgtctggcag gcggcgagtc ctcctgtgag     1860

ggaagagtgg agctcaagac actcggagcc tggggtcccc tctgcagttc tcattgggac     1920

atggaagatg ctcatgtctt atgtcagcag ctgaagtgtg gggttgccca atctattcca     1980

gaaggagcac attttgggaa aggagctggt caggtctgga gtcacatgtt ccactgcact     2040

ggaactgagg aacatatagg agattgcctc atgactgctc tgggtgcgcc gacgtgttcc     2100

gaaggacagg tggcctctgt catctgctca ggaaaccaat cccagacact attgccatgt     2160

agttcattgt ctccagtcca aacaacaagc tctacaattc caaaggagag tgaagttccc     2220

tgcatagcaa gtggccagct tcgcttggta ggtggaggtg gtcgctgcgc tggaagagtg     2280

gaggtctgcc acgagggctc ttggggcacc gtctgtgatg acaattggga tatgactgat     2340

gccaatgtgg tgtgcaagca gctggactgt ggcgtggcaa ttaacgccac tggctctgct     2400

tacttcgggg aaggagcagg agctatctgg ctagacgaag tcatctgcac tgggaaagag     2460

tctcatattt ggcagtgcca ttcacatggc tggggacgcc ataactgcag gcacaaagaa     2520

gatgcaggtg ttatctgctc cgagttcatg tctctgaggc tgaccaacga agcccacaaa     2580

gaaaactgca caggtcgcct tgaagtgttt tacaatggta catggggcag tattggcagt     2640

agcaatatgt ctccaaccac tgtgggggtg gtgtgccgtc agctgggctg tgcagacaac     2700

gggactgtga aacccatacc ttcagacaag acaccatcca ggcccatgtg ggtagatcgt     2760

gtgcagtgtc caaaaggagt tgacactttg tggcagtgcc cctcgtcacc ttggaaacag     2820

agacaggcca gcccctcctc ccaggagtcc tggatcatct gtgacaacaa aataagactc     2880

caggaagggc atacagactg ttctggacgt gtggagatct ggcacaaagg ttcctgggga     2940

acagtgtgtg atgactcctg ggatcttaat gatgctaagg ttgtatgtaa gcagttgggc     3000

tgtggccaag ctgtgaaggc actaaaagaa gcagcatttg gtccaggaac tgggcccata     3060

tggctcaatg aaattaagtg tagagggaat gagtcttccc tgtgggattg tcctgccaaa     3120

ccgtggagtc acagcgactg tgggcacaaa gaagatgctt ccatccagtg cctcccaaaa     3180

atgacttcag aatcacatca tggcacaggt caccccaccc tcacggcact cttggtttgt     3240

ggagccattc tattggtcct cctcattgtc ttcctcctgt ggactctgaa gcgacgacgg     3300

attcagcgac ttacagtttc ctcaagagga gaggtcttga tacatcaagt tcagtaccaa     3360

gagatggatt caaaggcgga tgatctggac ttgctgaaat cctcgggggt cattcagagg     3420

cacactgaga aggaaaatga taatttataa tccactgagg ttggagttta agaagccttg     3480

acaggacagc cagctaaatg gaacaagagc ccaggcaacg cacggatgac cacagctgca     3540

tcttcatgca gtcctttgtt tcctggaact ctgctgaacc tgcaaaaacc atatttgtga     3600

atgtgaccac ttaatagaga tgggagactt ttgagggaat taaacaatat tgctattggt     3660

ttgcttgttc gcaatagggt ctcattatgt atagccctgg agatggcgat agagagcagg     3720

caagcctaga attcacagag atctgcttgt ctctgcttcc caaatgctgg gatcaaatat     3780

gtggaccacc acatgtggtt taacaattgt gtcttgattt tataaatttc tggttggttt     3840

ttctgacgtt tttagggttt cgtgaatata aaataatgtc ttttcggttg gcatgctaat     3900

ttttaaatat tatacacttc cttgtagtga gtttaagaat aatttcttat aaccaagtca     3960

attcattttc actttgaatt atttaataaa ggaatatggt cattgtgacc acacacacag     4020

cagttgtgac cgcctgtatg aggccttcaa aaaatatttt aaaaatagag ggctggagaa     4080

atggctcaga ggtcctgagt tcaattccta gcaaccacat ggtggctcac aaccatctgt     4140

aatgggaatc cgatgccctc ttccagtgta tctgaagata gtgacactgt cctcattaac     4200

ataaaataaa taaataaatc tttaaaaaaa gaaaagacaa tagaggaggg gaggggcgtg     4260

agcgtaggag tgaggactga ttgagaagaa ggttggagga agtgggggga ggtgaaaagc     4320

tagttgggaa cttatgtgat cacagtgcat catgtccaaa tatgacatgt ccaaaaatgt     4380

tattaataaa gaaacggaaa tcaaa                                           4405


<210>  114
<211>  1121
<212>  PRT
<213>  Mus musculus

<400>  114

Met Gly Gly His Arg Met Val Leu Leu Gly Gly Ala Gly Ser Pro Gly 
1               5                   10                  15      


Cys Lys Arg Phe Val His Leu Gly Phe Phe Val Val Ala Val Ser Ser 
            20                  25                  30          


Leu Leu Ser Ala Ser Ala Val Thr Asn Ala Pro Gly Glu Met Lys Lys 
        35                  40                  45              


Glu Leu Arg Leu Ala Gly Gly Glu Asn Asn Cys Ser Gly Arg Val Glu 
    50                  55                  60                  


Leu Lys Ile His Asp Lys Trp Gly Thr Val Cys Ser Asn Gly Trp Ser 
65                  70                  75                  80  


Met Asn Glu Val Ser Val Val Cys Gln Gln Leu Gly Cys Pro Thr Ser 
                85                  90                  95      


Ile Lys Ala Leu Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Tyr Ile 
            100                 105                 110         


Trp Met Asp Lys Val Ser Cys Thr Gly Asn Glu Ser Ala Leu Trp Asp 
        115                 120                 125             


Cys Lys His Asp Gly Trp Gly Lys His Asn Cys Thr His Glu Lys Asp 
    130                 135                 140                 


Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg Leu Val 
145                 150                 155                 160 


Asn Ser Ala Gly His Arg Cys Leu Gly Arg Val Glu Ile Lys Phe Gln 
                165                 170                 175     


Gly Lys Trp Gly Thr Val Cys Asp Asp Asn Phe Ser Lys Asp His Ala 
            180                 185                 190         


Ser Val Ile Cys Lys Gln Leu Gly Cys Gly Ser Ala Ile Ser Phe Ser 
        195                 200                 205             


Gly Ser Ala Lys Leu Gly Ala Gly Ser Gly Pro Ile Trp Leu Asp Asp 
    210                 215                 220                 


Leu Ala Cys Asn Gly Asn Glu Ser Ala Leu Trp Asp Cys Lys His Arg 
225                 230                 235                 240 


Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Val Gly Val Ile 
                245                 250                 255     


Cys Leu Glu Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val Ser 
            260                 265                 270         


Arg Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly Thr 
        275                 280                 285             


Val Cys Asp Asp Asn Trp Asp Leu Arg Asp Ala Ser Val Val Cys Lys 
    290                 295                 300                 


Gln Leu Gly Cys Pro Thr Ala Ile Ser Ala Ile Gly Arg Val Asn Ala 
305                 310                 315                 320 


Ser Glu Gly Ser Gly Gln Ile Trp Leu Asp Asn Ile Ser Cys Glu Gly 
                325                 330                 335     


His Glu Ala Thr Leu Trp Glu Cys Lys His Gln Glu Trp Gly Lys His 
            340                 345                 350         


Tyr Cys His His Arg Glu Asp Ala Gly Val Thr Cys Ser Asp Gly Ala 
        355                 360                 365             


Asp Leu Glu Leu Arg Leu Val Gly Gly Gly Ser Arg Cys Ala Gly Ile 
    370                 375                 380                 


Val Glu Val Glu Ile Gln Lys Leu Thr Gly Lys Met Cys Ser Arg Gly 
385                 390                 395                 400 


Trp Thr Leu Ala Asp Ala Asp Val Val Cys Arg Gln Leu Gly Cys Gly 
                405                 410                 415     


Ser Ala Leu Gln Thr Gln Ala Lys Ile Tyr Ser Lys Thr Gly Ala Thr 
            420                 425                 430         


Asn Thr Trp Leu Phe Pro Gly Ser Cys Asn Gly Asn Glu Thr Thr Phe 
        435                 440                 445             


Trp Gln Cys Lys Asn Trp Gln Trp Gly Gly Leu Ser Cys Asp Asn Phe 
    450                 455                 460                 


Glu Glu Ala Lys Val Thr Cys Ser Gly His Arg Glu Pro Arg Leu Val 
465                 470                 475                 480 


Gly Gly Glu Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly Asp 
                485                 490                 495     


Val Trp Gly Ser Val Cys Asp Phe Asp Leu Ser Leu Glu Ala Ala Ser 
            500                 505                 510         


Val Val Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu Gly 
        515                 520                 525             


Gly Ala His Phe Gly Glu Gly Ser Gly Gln Ile Trp Gly Glu Glu Phe 
    530                 535                 540                 


Gln Cys Ser Gly Asp Glu Ser His Leu Ser Leu Cys Ser Val Ala Pro 
545                 550                 555                 560 


Pro Leu Asp Arg Thr Cys Thr His Ser Arg Asp Val Ser Val Val Cys 
                565                 570                 575     


Ser Arg Tyr Ile Asp Ile Arg Leu Ala Gly Gly Glu Ser Ser Cys Glu 
            580                 585                 590         


Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Pro Leu Cys Ser 
        595                 600                 605             


Ser His Trp Asp Met Glu Asp Ala His Val Leu Cys Gln Gln Leu Lys 
    610                 615                 620                 


Cys Gly Val Ala Gln Ser Ile Pro Glu Gly Ala His Phe Gly Lys Gly 
625                 630                 635                 640 


Ala Gly Gln Val Trp Ser His Met Phe His Cys Thr Gly Thr Glu Glu 
                645                 650                 655     


His Ile Gly Asp Cys Leu Met Thr Ala Leu Gly Ala Pro Thr Cys Ser 
            660                 665                 670         


Glu Gly Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln Thr 
        675                 680                 685             


Leu Leu Pro Cys Ser Ser Leu Ser Pro Val Gln Thr Thr Ser Ser Thr 
    690                 695                 700                 


Ile Pro Lys Glu Ser Glu Val Pro Cys Ile Ala Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Gly Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Val Cys His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Val Cys Asp Asp Asn Trp Asp Met Thr Asp 
            740                 745                 750         


Ala Asn Val Val Cys Lys Gln Leu Asp Cys Gly Val Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala Tyr Phe Gly Glu Gly Ala Gly Ala Ile Trp Leu Asp 
    770                 775                 780                 


Glu Val Ile Cys Thr Gly Lys Glu Ser His Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Arg His Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Asn Glu Ala His Lys 
            820                 825                 830         


Glu Asn Cys Thr Gly Arg Leu Glu Val Phe Tyr Asn Gly Thr Trp Gly 
        835                 840                 845             


Ser Ile Gly Ser Ser Asn Met Ser Pro Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Asn Gly Thr Val Lys Pro Ile Pro Ser 
865                 870                 875                 880 


Asp Lys Thr Pro Ser Arg Pro Met Trp Val Asp Arg Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Val Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Lys Gln 
            900                 905                 910         


Arg Gln Ala Ser Pro Ser Ser Gln Glu Ser Trp Ile Ile Cys Asp Asn 
        915                 920                 925             


Lys Ile Arg Leu Gln Glu Gly His Thr Asp Cys Ser Gly Arg Val Glu 
    930                 935                 940                 


Ile Trp His Lys Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp 
945                 950                 955                 960 


Leu Asn Asp Ala Lys Val Val Cys Lys Gln Leu Gly Cys Gly Gln Ala 
                965                 970                 975     


Val Lys Ala Leu Lys Glu Ala Ala Phe Gly Pro Gly Thr Gly Pro Ile 
            980                 985                 990         


Trp Leu Asn Glu Ile Lys Cys Arg  Gly Asn Glu Ser Ser  Leu Trp Asp 
        995                 1000                 1005             


Cys Pro  Ala Lys Pro Trp Ser  His Ser Asp Cys Gly  His Lys Glu 
    1010                 1015                 1020             


Asp Ala  Ser Ile Gln Cys Leu  Pro Lys Met Thr Ser  Glu Ser His 
    1025                 1030                 1035             


His Gly  Thr Gly His Pro Thr  Leu Thr Ala Leu Leu  Val Cys Gly 
    1040                 1045                 1050             


Ala Ile  Leu Leu Val Leu Leu  Ile Val Phe Leu Leu  Trp Thr Leu 
    1055                 1060                 1065             


Lys Arg  Arg Arg Ile Gln Arg  Leu Thr Val Ser Ser  Arg Gly Glu 
    1070                 1075                 1080             


Val Leu  Ile His Gln Val Gln  Tyr Gln Glu Met Asp  Ser Lys Ala 
    1085                 1090                 1095             


Asp Asp  Leu Asp Leu Leu Lys  Ser Ser Gly Val Ile  Gln Arg His 
    1100                 1105                 1110             


Thr Glu  Lys Glu Asn Asp Asn  Leu 
    1115                 1120     


<210>  115
<211>  1502
<212>  DNA
<213>  Mus musculus

<400>  115
gggcagagct cgcgtcattc agagtgagtc ccctctgcga gggaaagccg ggctactgca       60

gcgccaccag caagggattg ggactcacgg acttcagaac agaaggagcc tcagaaactg      120

tttaaatcat ggaaaaccac agcaagcaaa ctgaggctcc ccacccggga acatatatgc      180

cagctgggta tccccctccg tatccaccag cagctttcca aggaccttca gaccatgctg      240

cttaccccat accccaggct ggctaccaag ggcctccggg cccctatcca gggccccaac      300

ctggctaccc agtcccacca ggaggttatg caggtggtgg ccctagtggc tttcctgtcc      360

aaaatcagcc agcatataat catccaggtg ggcctggggg gaccccatgg atgccagccc      420

cccctcctcc actgaactgt ccaccggggc tggaatactt agctcagatt gatcagcttc      480

tggttcatca gcaaattgag cttctggaag tcttaacagg ctttgaaaca aataacaaat      540

atgaaatcaa gaacagcctc gggcagagag tttactttgc agtggaagat actgactgct      600

gtacccgaaa ctgctgtggg gcgtctagac ctttcacctt gaggatcctg gataatctgg      660

gccgagaagt catgactctg gagagacctc tgagatgcag tagctgctgc ttcccctgct      720

gcctccagga gatagaaatc caggctcctc ctggggtacc agtaggttat gtgactcaga      780

cctggcaccc atgtctgccc aagttcactc tccaaaatga gaagaagcag gatgtcctga      840

aagtagttgg tccgtgtgtt gtgtgtagct gctgttccga cattgacttt gagctcaaat      900

ctctagatga agaatcagta gttggcaaaa tttctaagca gtggtctggt tttgtgagag      960

aggccttcac ggatgcagac aattttggga tccagttccc gctagacctg gatgtgaaga     1020

tgaaagctgt gatgcttggt gcttgtttcc tcatagattt catgtttttt gaaagaactg     1080

gaaacgagga gcaaagatca ggagcatggc agtaactccc tgagagttct tgaggtttaa     1140

ggacgacaac tttatggacc ctgaatggaa actgaggaat cacaaggcac acaccgtggc     1200

ttcttttcct ttactgaaat aactttctat caactcacct gtgatgcctg ggtgccctgt     1260

tgtacaatta tgctcccaaa ttagagttta ttttttagaa ttctgtcatg tatttgtttt     1320

tatacattct taaggttttc actgtgaatt tgggaaaaca gttatgtgaa tttatataca     1380

tagaaatgat cttctctatg aaaacatact ttgactttgt ctttcgtttc ccatttttgt     1440

ggaaacgtaa atgctattgt aatttaatat aaaattacac attaaatata attatgattt     1500

ac                                                                    1502


<210>  116
<211>  328
<212>  PRT
<213>  Mus musculus

<400>  116

Met Glu Asn His Ser Lys Gln Thr Glu Ala Pro His Pro Gly Thr Tyr 
1               5                   10                  15      


Met Pro Ala Gly Tyr Pro Pro Pro Tyr Pro Pro Ala Ala Phe Gln Gly 
            20                  25                  30          


Pro Ser Asp His Ala Ala Tyr Pro Ile Pro Gln Ala Gly Tyr Gln Gly 
        35                  40                  45              


Pro Pro Gly Pro Tyr Pro Gly Pro Gln Pro Gly Tyr Pro Val Pro Pro 
    50                  55                  60                  


Gly Gly Tyr Ala Gly Gly Gly Pro Ser Gly Phe Pro Val Gln Asn Gln 
65                  70                  75                  80  


Pro Ala Tyr Asn His Pro Gly Gly Pro Gly Gly Thr Pro Trp Met Pro 
                85                  90                  95      


Ala Pro Pro Pro Pro Leu Asn Cys Pro Pro Gly Leu Glu Tyr Leu Ala 
            100                 105                 110         


Gln Ile Asp Gln Leu Leu Val His Gln Gln Ile Glu Leu Leu Glu Val 
        115                 120                 125             


Leu Thr Gly Phe Glu Thr Asn Asn Lys Tyr Glu Ile Lys Asn Ser Leu 
    130                 135                 140                 


Gly Gln Arg Val Tyr Phe Ala Val Glu Asp Thr Asp Cys Cys Thr Arg 
145                 150                 155                 160 


Asn Cys Cys Gly Ala Ser Arg Pro Phe Thr Leu Arg Ile Leu Asp Asn 
                165                 170                 175     


Leu Gly Arg Glu Val Met Thr Leu Glu Arg Pro Leu Arg Cys Ser Ser 
            180                 185                 190         


Cys Cys Phe Pro Cys Cys Leu Gln Glu Ile Glu Ile Gln Ala Pro Pro 
        195                 200                 205             


Gly Val Pro Val Gly Tyr Val Thr Gln Thr Trp His Pro Cys Leu Pro 
    210                 215                 220                 


Lys Phe Thr Leu Gln Asn Glu Lys Lys Gln Asp Val Leu Lys Val Val 
225                 230                 235                 240 


Gly Pro Cys Val Val Cys Ser Cys Cys Ser Asp Ile Asp Phe Glu Leu 
                245                 250                 255     


Lys Ser Leu Asp Glu Glu Ser Val Val Gly Lys Ile Ser Lys Gln Trp 
            260                 265                 270         


Ser Gly Phe Val Arg Glu Ala Phe Thr Asp Ala Asp Asn Phe Gly Ile 
        275                 280                 285             


Gln Phe Pro Leu Asp Leu Asp Val Lys Met Lys Ala Val Met Leu Gly 
    290                 295                 300                 


Ala Cys Phe Leu Ile Asp Phe Met Phe Phe Glu Arg Thr Gly Asn Glu 
305                 310                 315                 320 


Glu Gln Arg Ser Gly Ala Trp Gln 
                325             


<210>  117
<211>  3155
<212>  DNA
<213>  Mus musculus

<400>  117
ctgcaagcct agaaggcaga gcccaccgca gccgcgccag accaacgccc ctccgggcgc       60

ctcgccgcag taatggagaa agcacatgca gatgagtttc ctctgactac tgattcctca      120

gaaaagcaag gggttgtctg cattttcgga acaggggatt tcgggaagtc actgggattg      180

aaaatgcttc agtgtggcta ttctatcgtt tttgggagtc gaaaccccca ggtgtccagc      240

cttctgccca ggggggcaga ggtcctgagc tattcggaag cagcatccaa gtctgacatc      300

ataatcctag ccatgcacag agagcactat gattccctca cggaactagt tgattatctc      360

aaaggaaaag tattggtaga cgtcagtaac aaccgcaaaa tcaatcagta tccagagtca      420

aatgcggaat accttgctca gctggagcca ggagcccacg tggtcaaagc atttaacacc      480

atctcagcct gggctctcca gtcaggaaca ctagatgcaa gccggcaggt gtttgtctgt      540

ggaaatgaca gcaaggccaa acaaagagta atggacattg ctcgtactct tgggctcacc      600

ccactggacc aaggatctct catggcagcc agtgaaattg aaaactaccc tctgcaacta      660

tttccaatgt ggaggtttcc tttctatttg tcctctgtgc tgtgcgtctt cttctttgtg      720

tactgtgcaa tacgagaggt gatatacccc tacgtgaatg ggaaaacaga tgctacgtac      780

cgcctggcca tttccatccc gaatcgtgtc tttcctataa cagcactgat cctgcttgcc      840

ttggtgtacc tccctggtat tctcgctgcc attctgcagc tctatcgagg cacaaagtac      900

cgccgattcc caaactggct tgaccattgg atgctttgca gaaagcaact gggcttggta      960

gctctgggat ttgccttcct tcatgtcatc tacacacttg tgattcctat ccgttactat     1020

gttcgatgga ggctgagaaa tgcaaccatt actcaggccc taactaataa agacagccca     1080

tttattacct cttatgcctg gattaatgat tcctacttgg cgctgggaat cctgggattt     1140

tttctgttcc ttctgttggg aatcacttcc ttgccatcag taagcaacat ggtcaactgg     1200

agagagttcc ggtttgttca gtccaaactg ggttatctga ccctggtctt gtgcacagcc     1260

cacactttgg tgtatggcgg aaagagattc ctcagccctt cgattctaag gtggagcctc     1320

ccttcggctt atattttggc actcgtcatc ccctgcgcag tgctggtgct gaagtgcatc     1380

ctcatcatgc catgcataga caagaccctc actcgcatcc gccagggctg ggaaagaaac     1440

tcaaagtaca cacaatcagc actgaacgga aaatcggata tttaagctac agttgaattt     1500

gccaggattt gtgtactatt gcagtaaatg tttagagcat aatgtgtcca gttataagaa     1560

agcattttct cttgtcatgg ccctaacttt atcatcacag taggaagtgt tgcctcactt     1620

tgaaagacca gaatagcaag ggaaccctcg ctgcctcagt cacgtgatga ctcattgtgg     1680

gcctccctca cttcctttcc cagaaacccc agggatgcca ctgtgattag atttacagtt     1740

ccacacagcg aagcttcttg attatgggca agttgaatga cgcaatgttt tgtagagttc     1800

tggaagagtg tgtgcaactt ccttccctaa ttcaagggct gatgtaagtg aaaaagcagc     1860

actcggcata ctacaggttt tgcttggcat gcctggagaa aagccccaaa tgaaatagac     1920

agaaagaggg ttagtttgtt tcctggaaga agtggtgatc ataactattg tcatactgat     1980

ctgggggtat ttggggttta gctgtagtgc tgagctcaaa cctaaggcct tatgcatgtt     2040

aggtaaatga tatgttactg agccacacac acgccagccg tgccatagtg agtatgtagt     2100

catatgtacc cccttgattt cttgctttta ccaatatgga ttcttactat ggggaaatat     2160

tttatactgc aacaaaattg gtttgaagta gctgttcctt ggatatatgg aaagctatgt     2220

aattgtccca agattcttcc tccacaaagg acggcttgag gggagatggg gtaagagttg     2280

agcagcgatc ctaagttgag ggaagatggg gaaagagtgg aagatccatt gggtttttca     2340

agtgccgcag gcagacacag gctgataata gccttgtaca aaaatgtcag ataagccaga     2400

attttagcta gtaagctacg caaatactaa tacagtttca ctatgctgtt tgggatcatt     2460

taggagtggt ggtgtgcttt cttcattata catttcaaat actgttcagt attaagcatc     2520

tgtgaaatta acttctagta caaacatgta gcttccataa tctgtctttg ttatcaatgt     2580

aagtggtgca gttagaagga atcatctgaa ctcgtcggag cgaggaaagg atagctgaga     2640

gaactgtgga gtgctagggt gtaggcgagc agcagtggac catgggtcgg atgcagccag     2700

ctctggcttc ctgtgtggac agtgcctttc ccaaggtgac cttcagcagg ctgagaatcc     2760

ttagctctag cctggagcta aaaggagatc tttgcacaat cttcccgcgt gtcactgaaa     2820

taaagaaaag gcattgagtt tgacattttt ctgattaatc tacaaagact gtttattttt     2880

catttttcta gcttttatat cgtatattgt acatgatatc atacattgct cacaatccag     2940

ggttttttat ataaagctct tatataacac agacatttct tttactattg ccctaataaa     3000

acatatagag tatattcagt ttttactaag aggacaattg aggtaatgtc tttgtactaa     3060

caaaatattt ctgtattttc aattatttcc ttggaatatt ttccaagagt tagtataaaa     3120

ttaaagaata tttgataaca aaaaaaaaaa aaaaa                                3155


<210>  118
<211>  470
<212>  PRT
<213>  Mus musculus

<400>  118

Met Glu Lys Ala His Ala Asp Glu Phe Pro Leu Thr Thr Asp Ser Ser 
1               5                   10                  15      


Glu Lys Gln Gly Val Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Lys 
            20                  25                  30          


Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Ile Val Phe Gly 
        35                  40                  45              


Ser Arg Asn Pro Gln Val Ser Ser Leu Leu Pro Arg Gly Ala Glu Val 
    50                  55                  60                  


Leu Ser Tyr Ser Glu Ala Ala Ser Lys Ser Asp Ile Ile Ile Leu Ala 
65                  70                  75                  80  


Met His Arg Glu His Tyr Asp Ser Leu Thr Glu Leu Val Asp Tyr Leu 
                85                  90                  95      


Lys Gly Lys Val Leu Val Asp Val Ser Asn Asn Arg Lys Ile Asn Gln 
            100                 105                 110         


Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala Gln Leu Glu Pro Gly Ala 
        115                 120                 125             


His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser 
    130                 135                 140                 


Gly Thr Leu Asp Ala Ser Arg Gln Val Phe Val Cys Gly Asn Asp Ser 
145                 150                 155                 160 


Lys Ala Lys Gln Arg Val Met Asp Ile Ala Arg Thr Leu Gly Leu Thr 
                165                 170                 175     


Pro Leu Asp Gln Gly Ser Leu Met Ala Ala Ser Glu Ile Glu Asn Tyr 
            180                 185                 190         


Pro Leu Gln Leu Phe Pro Met Trp Arg Phe Pro Phe Tyr Leu Ser Ser 
        195                 200                 205             


Val Leu Cys Val Phe Phe Phe Val Tyr Cys Ala Ile Arg Glu Val Ile 
    210                 215                 220                 


Tyr Pro Tyr Val Asn Gly Lys Thr Asp Ala Thr Tyr Arg Leu Ala Ile 
225                 230                 235                 240 


Ser Ile Pro Asn Arg Val Phe Pro Ile Thr Ala Leu Ile Leu Leu Ala 
                245                 250                 255     


Leu Val Tyr Leu Pro Gly Ile Leu Ala Ala Ile Leu Gln Leu Tyr Arg 
            260                 265                 270         


Gly Thr Lys Tyr Arg Arg Phe Pro Asn Trp Leu Asp His Trp Met Leu 
        275                 280                 285             


Cys Arg Lys Gln Leu Gly Leu Val Ala Leu Gly Phe Ala Phe Leu His 
    290                 295                 300                 


Val Ile Tyr Thr Leu Val Ile Pro Ile Arg Tyr Tyr Val Arg Trp Arg 
305                 310                 315                 320 


Leu Arg Asn Ala Thr Ile Thr Gln Ala Leu Thr Asn Lys Asp Ser Pro 
                325                 330                 335     


Phe Ile Thr Ser Tyr Ala Trp Ile Asn Asp Ser Tyr Leu Ala Leu Gly 
            340                 345                 350         


Ile Leu Gly Phe Phe Leu Phe Leu Leu Leu Gly Ile Thr Ser Leu Pro 
        355                 360                 365             


Ser Val Ser Asn Met Val Asn Trp Arg Glu Phe Arg Phe Val Gln Ser 
    370                 375                 380                 


Lys Leu Gly Tyr Leu Thr Leu Val Leu Cys Thr Ala His Thr Leu Val 
385                 390                 395                 400 


Tyr Gly Gly Lys Arg Phe Leu Ser Pro Ser Ile Leu Arg Trp Ser Leu 
                405                 410                 415     


Pro Ser Ala Tyr Ile Leu Ala Leu Val Ile Pro Cys Ala Val Leu Val 
            420                 425                 430         


Leu Lys Cys Ile Leu Ile Met Pro Cys Ile Asp Lys Thr Leu Thr Arg 
        435                 440                 445             


Ile Arg Gln Gly Trp Glu Arg Asn Ser Lys Tyr Thr Gln Ser Ala Leu 
    450                 455                 460                 


Asn Gly Lys Ser Asp Ile 
465                 470 


<210>  119
<211>  739
<212>  DNA
<213>  Mus musculus

<400>  119
gcaatggcac tgcacatgat tcttgtcatg gtgagcctcc tgccgctgtt ggaagctcag       60

aacccagaac atgtcaacat caccataggc gaccctatca ccaatgagac cctgagctgg      120

ctctctgaca aatggttttt cattggtgcg gctgtcctaa accctgatta ccggcaggaa      180

attcaaaaga cgcagatggt attttttaac cttaccccca acttgataaa tgacacgatg      240

gagcttcgag agtatcacac catagatgac cactgtgtct ataactccac tcatctagga      300

atccagagag agaatgggac cctctccaag tatgtaggag gagtaaaaat ctttgcagac      360

ctgatagtct tgaagatgca tggggccttc atgcttgcct ttgacttgaa ggatgagaag      420

aaacggggac tgtccctcaa tgcaaaaagg ccagatatca ccccggagct gcgggaagta      480

ttccagaagg ctgtcacaca cgtgggcatg gatgaatcag aaatcatatt tgtcgactgg      540

aaaaaggaca ggtgcagtca gcaggagaag cagcagcttg agctggagaa ggagaccaag      600

aaagatcctg aggaaggcca ggcatgaact cagctctctg aactccgagg gctgtccaca      660

ggctcaccaa accccacccc tcctgtgcac tttgattctg tctctgccac aataaaggtt      720

tgctgacaca gtcaatatc                                                   739


<210>  120
<211>  207
<212>  PRT
<213>  Mus musculus

<400>  120

Met Ala Leu His Met Ile Leu Val Met Val Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Asn Pro Glu His Val Asn Ile Thr Ile Gly Asp Pro Ile 
            20                  25                  30          


Thr Asn Glu Thr Leu Ser Trp Leu Ser Asp Lys Trp Phe Phe Ile Gly 
        35                  40                  45              


Ala Ala Val Leu Asn Pro Asp Tyr Arg Gln Glu Ile Gln Lys Thr Gln 
    50                  55                  60                  


Met Val Phe Phe Asn Leu Thr Pro Asn Leu Ile Asn Asp Thr Met Glu 
65                  70                  75                  80  


Leu Arg Glu Tyr His Thr Ile Asp Asp His Cys Val Tyr Asn Ser Thr 
                85                  90                  95      


His Leu Gly Ile Gln Arg Glu Asn Gly Thr Leu Ser Lys Tyr Val Gly 
            100                 105                 110         


Gly Val Lys Ile Phe Ala Asp Leu Ile Val Leu Lys Met His Gly Ala 
        115                 120                 125             


Phe Met Leu Ala Phe Asp Leu Lys Asp Glu Lys Lys Arg Gly Leu Ser 
    130                 135                 140                 


Leu Asn Ala Lys Arg Pro Asp Ile Thr Pro Glu Leu Arg Glu Val Phe 
145                 150                 155                 160 


Gln Lys Ala Val Thr His Val Gly Met Asp Glu Ser Glu Ile Ile Phe 
                165                 170                 175     


Val Asp Trp Lys Lys Asp Arg Cys Ser Gln Gln Glu Lys Gln Gln Leu 
            180                 185                 190         


Glu Leu Glu Lys Glu Thr Lys Lys Asp Pro Glu Glu Gly Gln Ala 
        195                 200                 205         


<210>  121
<211>  853
<212>  DNA
<213>  Mus musculus

<400>  121
agacctagta gctgtggaaa ccatggccct gagtgtcatg tgtctgggcc ttgccctgct       60

tggggtcctg cagagccagg cccaggactc aactcagaac ttgatccctg ccccatctct      120

gctcactgtc cccctgcagc cagacttccg gagcgatcag ttccggggca ggtggtacgt      180

tgtgggcctg gcaggcaatg cggtccagaa aaaaacagaa ggcagcttta cgatgtacag      240

caccatctat gagctacaag agaacaatag ctacaatgtc acctccatcc tggtcaggga      300

ccaggaccag ggctgtcgct actggatcag aacatttgtt ccaagctcca gggctggcca      360

gttcactctg ggaaatatgc acaggtatcc tcaggtacag agctacaatg tgcaagtggc      420

caccacggac tacaaccagt tcgccatggt atttttccga aagacttctg aaaacaagca      480

atacttcaaa attaccctgt atggaagaac caaggagctg tcccctgaac tgaaggaacg      540

tttcacccgc tttgccaagt ctctgggcct caaggacgac aacatcatct tctctgtccc      600

caccgaccaa tgcattgaca actgaatggg tggtgagtgt ggctgactgg gatgcgcaga      660

gacccaatgg ttcaggcgct gcctgtctgt ctgccactcc atctttcctg ttgccagaga      720

gccacctggc tgccccacca gccaccatac caaggagcat ctggagcctc ttcttatttg      780

gccagcactc cccatccacc tgtcttaaca ccaccaatgg cgtccccttt ctgctgaata      840

aatacatgcc ccc                                                         853


<210>  122
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  122

Met Ala Leu Ser Val Met Cys Leu Gly Leu Ala Leu Leu Gly Val Leu 
1               5                   10                  15      


Gln Ser Gln Ala Gln Asp Ser Thr Gln Asn Leu Ile Pro Ala Pro Ser 
            20                  25                  30          


Leu Leu Thr Val Pro Leu Gln Pro Asp Phe Arg Ser Asp Gln Phe Arg 
        35                  40                  45              


Gly Arg Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Val Gln Lys Lys 
    50                  55                  60                  


Thr Glu Gly Ser Phe Thr Met Tyr Ser Thr Ile Tyr Glu Leu Gln Glu 
65                  70                  75                  80  


Asn Asn Ser Tyr Asn Val Thr Ser Ile Leu Val Arg Asp Gln Asp Gln 
                85                  90                  95      


Gly Cys Arg Tyr Trp Ile Arg Thr Phe Val Pro Ser Ser Arg Ala Gly 
            100                 105                 110         


Gln Phe Thr Leu Gly Asn Met His Arg Tyr Pro Gln Val Gln Ser Tyr 
        115                 120                 125             


Asn Val Gln Val Ala Thr Thr Asp Tyr Asn Gln Phe Ala Met Val Phe 
    130                 135                 140                 


Phe Arg Lys Thr Ser Glu Asn Lys Gln Tyr Phe Lys Ile Thr Leu Tyr 
145                 150                 155                 160 


Gly Arg Thr Lys Glu Leu Ser Pro Glu Leu Lys Glu Arg Phe Thr Arg 
                165                 170                 175     


Phe Ala Lys Ser Leu Gly Leu Lys Asp Asp Asn Ile Ile Phe Ser Val 
            180                 185                 190         


Pro Thr Asp Gln Cys Ile Asp Asn 
        195                 200 


<210>  123
<211>  3940
<212>  DNA
<213>  Mus musculus

<400>  123
tcgccacggc cccatctgac gagcggccat tcatcaggcc cgctggccta tcaatgacat       60

tgctcccatc ggggctccta taaaatgatg ttttttccca tgaaacatcc gcaaacattt      120

tgacgggttt ggctttgccc gactggatta ctgagtgtcc cctcgctcgc tcgctcgctc      180

tctcgctctc tccttcagct ctagcttcct tccttccctc gcttcttcgc ctcttttctt      240

tccactagtt ctttcttttc cccttttatc cttttgccct ctcacccacc gtctccccct      300

ctctctctcg ctatcccttc cttccttatt tcttccctcc cttcctccct gggcatctct      360

agcacagggg atccccaaat atcaggactt ttggggggcg tctgtgctgt ccatgggaag      420

agcatgcatt gtgggttact ggaggaaccc gacatggatt ccacagagag ctggattgaa      480

agatgtctca atgaaagcga gaataaacgc tattccagtc acacatctct ggggaatgtg      540

tctaatgatg aaaatgagga aaaagaaaat aacagagcat ccaagcccca ctccacgccg      600

gccaccctgc aatggctgga ggaaaactat gagattgctg agggcgtctg catcccccgc      660

agcgccctct acatgcacta cctggatttc tgtgagaaga acgacactca gcctgtcaat      720

gctgccagct ttgggaagat cataaggcag cagtttcctc agctaaccac cagaagactc      780

gggacccgag gacagtcaaa gtaccattac tatggcatag cggtgaagga gagctcccag      840

tattatgatg tgatgtactc aaagaaagga gctgcctggg tgagcgagac gggcaagaga      900

gaagtcacca agcagacggt ggcatattct ccccggtcca agcttgggac attgctgcca      960

gactttccaa acgtcaaaga cctaaatctg ccagccagtc ttcctgagga gaaggtgtct     1020

acctttatta tgatgtacag aacacactgt cagagaatac tggacactgt aataagagcc     1080

aactttgatg aggttcaaag tttccttctg cacttttggc aagggatgcc gccccacatg     1140

ctgcccgtgc taggctcctc cacggtggtg aacatcgtgg gtgtgtgtga ctccatcctc     1200

tacaaagcca tctccggtgt gttgatgccc acggtgctgc aggcgttgcc ggacagctta     1260

actcaggtga tccgaaagtt tgccaagcag ctggacgagt ggctgaaagt ggctctccac     1320

gatctcccgg aaaacctgag aaacatcaaa tttgaattat caaggaggtt ttcccaaatc     1380

ctaaggaggc aaacatcgct gaaccatctg tgccaggcat ctcgaacggt gatccacagt     1440

gcagacatca cgttccagat gctggaggac tggaggaatg tggacctgag tagcatcacc     1500

aagcagactc tgtataccat ggaggactct cgggatgagc accgcagact catcatccag     1560

ttgtaccagg agtttgacca cctgctggag gaacagtccc ccatcgagtc ttacatagaa     1620

tggctggata ccatggtaga ccgatgcgtt gtaaaggtgg ctgccaagag acaagggtct     1680

ctgaagaaag tagcccaaca gttcctgctg atgtggtctt gctttggtac gagggtgatc     1740

cgggacatga ccttgcacag tgcccccagc ttcgggtctt ttcacctgat tcacctgatg     1800

ttcgacgact acgtgctcta cttgctagaa tctctgcatt gtcaggagcg ggccaacgag     1860

ctcatgcgag ccatgaaagg agaaggaagc actgcagaag cccaggaaga gattatcttg     1920

acagaggcta ccccaccaac cccttcacct ggtccatcat tttctccagc aaagtctgcc     1980

acatctgtgg aggtgccacc tccctcctcc cctgtcagca acccatcccc cgaatacact     2040

ggccttagca cagcaggagc gatgcagtca tatacgtggt cgctaacata tacagtaaca     2100

acggctgcag ggtcaccggc tgagaactcc caacaactac cctgtatgag gagcacccat     2160

atgccttctt cctccgtcac acacaggata ccagtctact cccacagaga ggagcatggg     2220

tacacgggaa gctataacta cgggagctat ggcaaccagc atcctcaccc actgcagaac     2280

cagtatccag ccttgcctca tgacacagcc atctctgggc ctctccacta ttccccttac     2340

cacaggagct ctgcccagta ccctttcaat agccccactt ccaggatgga accttgtttg     2400

atgagcagta ctcccaggct gcatcctacc ccagtgactc cccgatggcc agaggtgccg     2460

actgccaacg catgctacac aagcccatct gtgcattcca cgaggtatgg aaactctagt     2520

gacatgtaca ccccgctgac cacgcgcagg aattctgagt atgagcacat gcaacacttt     2580

cctggctttg cttacatcaa cggagaggcc tccactggat gggctaagtg actgctttca     2640

tagaaatcca tatttaatat taataattaa taataataat aaacccagta cccaccctcc     2700

agaagacttt atttcaatac atcataactt gcgggctgac ctaagcatcc attctcctaa     2760

tgaacaagag gatgttcaat gtggagtgaa tagactttag ttcagaaaca ggagtcacta     2820

aaagtcagtg ggattgggtt tctgtagcca agccagactt gactgtttct atagagcact     2880

atcttgggca ggccaatctg tgcctttccc ctctgttcca tgaccttgca tggcaactac     2940

tccttgtata gggtacttat tttcttgttg acaaagctct ttagtcttga aggatggata     3000

ctggagccag aatctggttt gtgttcttgg acgggcacat aatttaccaa gagcattcac     3060

cttgccacct gtctgtctgt cacctcgctg tacggttacc agccctcaga catgtaatcc     3120

acatcccgac ttcctggtga tgtcattcct acttcctgga gtccctggaa gtttttgaaa     3180

atgctaagct ccctgctaag ttccattcgt acctgccata ttacctgcat tgtcctggac     3240

tgtaagcact gttgttgagg gacagaagag gcctgttata tattgccttt cgttgattga     3300

tgtctgtagg gaccagttct tctctgtaca aggatttgtc ctaagtttgc acaatggcta     3360

gcatcagcaa aaggcaggag agggttttct taagttctgt gagaaatgtg gatttatggc     3420

actaaacact gtcctccact gtgttacttt gcgaagctgg atggagcaga ctttcactta     3480

gcaagcacca agtgtgaaaa caactgtctg gtttcttcat aagactagaa tactttctga     3540

cactttgcta gaaaaaaaaa attcaaagct gtgcctttga gtctatacta tactgtgtat     3600

gtgtggaaat aaaaaaaatg tattgtactt tgggaaaatt ttttcttagg tattttttgt     3660

cagatttgta gctatttgtg aggtttgtta gagattaaca taggttttct ttctgtatta     3720

taagatgcac caagcaatta tggtggacct attaccctat gggtaagaaa taaatggaaa     3780

tatgacatcg gatgttttag caaatgttct gtaaataaaa tgtttgatca caccacccag     3840

tgtgataatc atgtctacag ctaaaatgga aatagtttta tctgtacagt tgtgcaagat     3900

atggatggtt tcacactcaa ataaaaagta ttgaaatgac                           3940


<210>  124
<211>  735
<212>  PRT
<213>  Mus musculus

<400>  124

Met His Cys Gly Leu Leu Glu Glu Pro Asp Met Asp Ser Thr Glu Ser 
1               5                   10                  15      


Trp Ile Glu Arg Cys Leu Asn Glu Ser Glu Asn Lys Arg Tyr Ser Ser 
            20                  25                  30          


His Thr Ser Leu Gly Asn Val Ser Asn Asp Glu Asn Glu Glu Lys Glu 
        35                  40                  45              


Asn Asn Arg Ala Ser Lys Pro His Ser Thr Pro Ala Thr Leu Gln Trp 
    50                  55                  60                  


Leu Glu Glu Asn Tyr Glu Ile Ala Glu Gly Val Cys Ile Pro Arg Ser 
65                  70                  75                  80  


Ala Leu Tyr Met His Tyr Leu Asp Phe Cys Glu Lys Asn Asp Thr Gln 
                85                  90                  95      


Pro Val Asn Ala Ala Ser Phe Gly Lys Ile Ile Arg Gln Gln Phe Pro 
            100                 105                 110         


Gln Leu Thr Thr Arg Arg Leu Gly Thr Arg Gly Gln Ser Lys Tyr His 
        115                 120                 125             


Tyr Tyr Gly Ile Ala Val Lys Glu Ser Ser Gln Tyr Tyr Asp Val Met 
    130                 135                 140                 


Tyr Ser Lys Lys Gly Ala Ala Trp Val Ser Glu Thr Gly Lys Arg Glu 
145                 150                 155                 160 


Val Thr Lys Gln Thr Val Ala Tyr Ser Pro Arg Ser Lys Leu Gly Thr 
                165                 170                 175     


Leu Leu Pro Asp Phe Pro Asn Val Lys Asp Leu Asn Leu Pro Ala Ser 
            180                 185                 190         


Leu Pro Glu Glu Lys Val Ser Thr Phe Ile Met Met Tyr Arg Thr His 
        195                 200                 205             


Cys Gln Arg Ile Leu Asp Thr Val Ile Arg Ala Asn Phe Asp Glu Val 
    210                 215                 220                 


Gln Ser Phe Leu Leu His Phe Trp Gln Gly Met Pro Pro His Met Leu 
225                 230                 235                 240 


Pro Val Leu Gly Ser Ser Thr Val Val Asn Ile Val Gly Val Cys Asp 
                245                 250                 255     


Ser Ile Leu Tyr Lys Ala Ile Ser Gly Val Leu Met Pro Thr Val Leu 
            260                 265                 270         


Gln Ala Leu Pro Asp Ser Leu Thr Gln Val Ile Arg Lys Phe Ala Lys 
        275                 280                 285             


Gln Leu Asp Glu Trp Leu Lys Val Ala Leu His Asp Leu Pro Glu Asn 
    290                 295                 300                 


Leu Arg Asn Ile Lys Phe Glu Leu Ser Arg Arg Phe Ser Gln Ile Leu 
305                 310                 315                 320 


Arg Arg Gln Thr Ser Leu Asn His Leu Cys Gln Ala Ser Arg Thr Val 
                325                 330                 335     


Ile His Ser Ala Asp Ile Thr Phe Gln Met Leu Glu Asp Trp Arg Asn 
            340                 345                 350         


Val Asp Leu Ser Ser Ile Thr Lys Gln Thr Leu Tyr Thr Met Glu Asp 
        355                 360                 365             


Ser Arg Asp Glu His Arg Arg Leu Ile Ile Gln Leu Tyr Gln Glu Phe 
    370                 375                 380                 


Asp His Leu Leu Glu Glu Gln Ser Pro Ile Glu Ser Tyr Ile Glu Trp 
385                 390                 395                 400 


Leu Asp Thr Met Val Asp Arg Cys Val Val Lys Val Ala Ala Lys Arg 
                405                 410                 415     


Gln Gly Ser Leu Lys Lys Val Ala Gln Gln Phe Leu Leu Met Trp Ser 
            420                 425                 430         


Cys Phe Gly Thr Arg Val Ile Arg Asp Met Thr Leu His Ser Ala Pro 
        435                 440                 445             


Ser Phe Gly Ser Phe His Leu Ile His Leu Met Phe Asp Asp Tyr Val 
    450                 455                 460                 


Leu Tyr Leu Leu Glu Ser Leu His Cys Gln Glu Arg Ala Asn Glu Leu 
465                 470                 475                 480 


Met Arg Ala Met Lys Gly Glu Gly Ser Thr Ala Glu Ala Gln Glu Glu 
                485                 490                 495     


Ile Ile Leu Thr Glu Ala Thr Pro Pro Thr Pro Ser Pro Gly Pro Ser 
            500                 505                 510         


Phe Ser Pro Ala Lys Ser Ala Thr Ser Val Glu Val Pro Pro Pro Ser 
        515                 520                 525             


Ser Pro Val Ser Asn Pro Ser Pro Glu Tyr Thr Gly Leu Ser Thr Ala 
    530                 535                 540                 


Gly Ala Met Gln Ser Tyr Thr Trp Ser Leu Thr Tyr Thr Val Thr Thr 
545                 550                 555                 560 


Ala Ala Gly Ser Pro Ala Glu Asn Ser Gln Gln Leu Pro Cys Met Arg 
                565                 570                 575     


Ser Thr His Met Pro Ser Ser Ser Val Thr His Arg Ile Pro Val Tyr 
            580                 585                 590         


Ser His Arg Glu Glu His Gly Tyr Thr Gly Ser Tyr Asn Tyr Gly Ser 
        595                 600                 605             


Tyr Gly Asn Gln His Pro His Pro Leu Gln Asn Gln Tyr Pro Ala Leu 
    610                 615                 620                 


Pro His Asp Thr Ala Ile Ser Gly Pro Leu His Tyr Ser Pro Tyr His 
625                 630                 635                 640 


Arg Ser Ser Ala Gln Tyr Pro Phe Asn Ser Pro Thr Ser Arg Met Glu 
                645                 650                 655     


Pro Cys Leu Met Ser Ser Thr Pro Arg Leu His Pro Thr Pro Val Thr 
            660                 665                 670         


Pro Arg Trp Pro Glu Val Pro Thr Ala Asn Ala Cys Tyr Thr Ser Pro 
        675                 680                 685             


Ser Val His Ser Thr Arg Tyr Gly Asn Ser Ser Asp Met Tyr Thr Pro 
    690                 695                 700                 


Leu Thr Thr Arg Arg Asn Ser Glu Tyr Glu His Met Gln His Phe Pro 
705                 710                 715                 720 


Gly Phe Ala Tyr Ile Asn Gly Glu Ala Ser Thr Gly Trp Ala Lys 
                725                 730                 735 


<210>  125
<211>  3324
<212>  DNA
<213>  Mus musculus

<400>  125
gcctccttcc tctgcctcca ccctcacccc ttcccgtcgg tgcggagctc cgctccgagc       60

agcgctcagc ccgccgcagc ttggatgtgg gctcgggaca agtgctccgt tcctcagctc      120

gagatggaca gccgctacac cagcgccacg ggcatcgggg acttgaacca gctgagtgcg      180

gccatccccg ccacacgagt ggaggtgtca gtgtcctgca gaaatctcct tgatagagat      240

acattttcta agtcggatcc aatttgtgtc ctatatacac aagcagttgg gaataaagaa      300

tggagagagt ttggaagaac tgaagtgatc gataatactt tgaatcctga ttttgtaaga      360

aagtttatcc tggattattt ctttgaagaa agagagaatc ttcgttttga cttatatgat      420

gttgattcta agagtcccaa cttgtccaaa catgactttc tgggacaagt gttttgtaca      480

ttgggggaga ttgttggttc acagggaagt cgcctggaaa agccaatagt aggaattcca      540

ggcaggaaat gtgggacaat catactgacg gcagaggagc taaactgctg cagggatgct      600

gtcttgatgc agttctgtgc aaacaaattg gataagaagg atttctttgg gaagtcagat      660

cctttcctgg tattttatcg aagcaatgag gatggaagct ttacaatttg ccacaagaca      720

gaagtggtca aaaacactct aaatcctgtg tggcaagcgt tcaagatctc agtgcgagca      780

ttgtgcaatg gggactatga cagaacaatc aaggtagaag tgtacgactg ggaccgagac      840

gggagtcatg atttcattgg agaattcaca acaagctatc gggagctcgc aagagggcag      900

tcacaattca acgtctatga ggtggtgaat cccaaaaaga aaggaaaaaa gaaaaaatac      960

accaattcag gaacagtaac cttattgtcc ttcttggtgg aaacagaagt ctccttcctg     1020

gactatatta aaggaggaac gcagatcaac ttcacggtgg ccattgattt tacagcatca     1080

aatggaaacc ctgcccagcc aacttctctc cactatatga acccttacca actgaatgcc     1140

tatggaatgg cactgaaggc tgtaggagaa atcgttcaag attatgacag tgataagatg     1200

ttcccagccc tgggttttgg tgcaaagctg cctccagatg gaaggatatc tcacgagttt     1260

gccctgaatg gcaaccctca gaatccttac tgtgatggca ttgaaggtgt catggaagct     1320

tactatagaa gtctgaagtc tgtccagttg tatgggccaa ccaactttgc tcccgtaata     1380

aaccacgtag caagatacgc atcctctgta aaagatggct cccagtactt tgtgcttctc     1440

attgtgacgg acggcgtcat ctcagatatg gctcaaacta aagaatccat agttaatgcc     1500

tcaaagcttc ccatgtcaat aataatagta ggtgtgggac ctgcagaatt tgatgcaatg     1560

gttgaattgg atggagatga tgtaagagtt tcctccagag ggaaatatgc tgaaagagat     1620

attgtacagt ttgtgccgtt cagggattat attgacagaa gtggaaacca catactcagc     1680

atggcgagac tggccaaaga tgtcttagct gagatcccag agcagttcct ttcctacatg     1740

agagccagag gaatcaagcc atcaccggcg cccccgccgt acacccctcc tacacacgtg     1800

ctgcagacgc aaatatgacc acgcccagat gctgatgtcc ctcacacgcc agtcggaact     1860

gcgaagcctg tgctttgatc ctggtgctct gctttgaacc agggaatgag acactttctc     1920

agtttggttt cagcagtcct ggaaaatgtg ctttcttgga tccaaattac attctcttcc     1980

taaaccaaaa ctgtaaatag ggttgttgca tgagcaaccg ggaaattgtt taagatgctt     2040

gaagcaaagt agagatgtct tctctaattt ttgaatattt ttgttttttt gttcatgacg     2100

gaatagtaaa tttccaatgt attattggga aaaagcacaa gctacatttt taacacaaat     2160

gttgtccttg actgctacat atataggccg gcagtctctg tgtcgatgtt tacacgttac     2220

tactttttaa atttcaatac ttttataact gttcttaaga gtaagtttta aatattgaat     2280

cctttgtctt ctaaattgca atagctataa tcacaggagc aatatctctt tgaatgactg     2340

tctggacatt catggtatga ataagggaag agaaggaggt agaatctact tagtgattaa     2400

tatccatttt ggtcaaccgt gggagtttca acttataaac agatgtggcc ctgtaatatg     2460

catttttttc atggactttg ggtttaaatt tagactgcag tcaatttatc tttcaaatgc     2520

caactagaag caatgaacag gcaaacatcg tgaactgtta atgcacagaa tatactttgt     2580

ataaaaacca ccatccttat aacactatga tttagtgtgt aaaaacaaga ctatataact     2640

ccaaaccatg tagcaggtgt attgaacttt gtattcagtt atatcctgtc tagatatttt     2700

gattcaaagg gatactggct ctcttgcttt ggaatttata ttctcaccct tccatcttgc     2760

cttcacgggt tgcacaggct ggagtctctt gtgagttctc agttccacgt acacacaacc     2820

ctgtgactta gcacacaaca cgtttgtgaa ataaactcat tcctgtgccc caacctgcct     2880

gtttgtgaaa taacccatcc ctctaccctg acctgcctgc tcacaaccaa ttctaaatag     2940

ttttcaatgt acagttttta tacgaattac agttttgtga agttacgtct acatttcttt     3000

agaacaaatg gccttaaatt ctcacagaat tcctggaaat gattgtgaat tgccttcaaa     3060

atacagaaat gtgtatttgt ttgttgttct tttttgtgtc aacagtgtga ctgctttcta     3120

acctctctgc ctccccctct ttgctacttg gattcttcct attgtgtgtg ctcttgccac     3180

aacttggatc tatggtgact tttataagca tgaagctgtt ttactggaga atatgcataa     3240

tcctcatagc taacagagtc acagttacat aactgtgacg tgaattgtcc atttttaagt     3300

acctattaaa acatttaaaa ggat                                            3324


<210>  126
<211>  718
<212>  DNA
<213>  Mus musculus

<400>  126
gcctccttcc tctgcctcca ccctcacccc ttcccgtcgg tgcggagctc cgctccgagc       60

agcgctcagc ccgccgcagc ttggatgtgg gctcgggaca agtgctccgt tcctcagctc      120

gagatggaca gccgctacac cagcgccacg ggcatcgggg acttgaacca gctgagtgcg      180

gccatccccg ccacacgagt ggaggtgtca gtgtcctgca gaaatctcct tgatagagat      240

acattttcta agtcggatcc aatttgtgtc ctatatacac aagcagttgg gaataaagaa      300

tggagagagg aggctgctcc cctggaagag ccattacatc gttgggagaa cagcacacag      360

tattacctcg tcagagccct ccactcagcc ctgctgtagg gtgtgggaag ccgcccccac      420

attcgccgtc acaagatggc gctgacatcc tgtgttctaa gttggtaaac aaatagtctg      480

cgcatgagcc aagggtattt acgactactt gtactctgtt tttcccgtga acgtcagctc      540

ggccatgggc tgcagccaat cagggagtga tgcgtcctag gcaattgttg ttctctttaa      600

agaggaaagg ggtttcgttt tctctctctc ttgcttcgct ctctcttgct tcttacactc      660

tggccccata agatgtaagc aataaagctt tgccgtagaa aaaaaaaaaa aaaaaaaa        718


<210>  127
<211>  564
<212>  PRT
<213>  Mus musculus

<400>  127

Met Asp Ser Arg Tyr Thr Ser Ala Thr Gly Ile Gly Asp Leu Asn Gln 
1               5                   10                  15      


Leu Ser Ala Ala Ile Pro Ala Thr Arg Val Glu Val Ser Val Ser Cys 
            20                  25                  30          


Arg Asn Leu Leu Asp Arg Asp Thr Phe Ser Lys Ser Asp Pro Ile Cys 
        35                  40                  45              


Val Leu Tyr Thr Gln Ala Val Gly Asn Lys Glu Trp Arg Glu Phe Gly 
    50                  55                  60                  


Arg Thr Glu Val Ile Asp Asn Thr Leu Asn Pro Asp Phe Val Arg Lys 
65                  70                  75                  80  


Phe Ile Leu Asp Tyr Phe Phe Glu Glu Arg Glu Asn Leu Arg Phe Asp 
                85                  90                  95      


Leu Tyr Asp Val Asp Ser Lys Ser Pro Asn Leu Ser Lys His Asp Phe 
            100                 105                 110         


Leu Gly Gln Val Phe Cys Thr Leu Gly Glu Ile Val Gly Ser Gln Gly 
        115                 120                 125             


Ser Arg Leu Glu Lys Pro Ile Val Gly Ile Pro Gly Arg Lys Cys Gly 
    130                 135                 140                 


Thr Ile Ile Leu Thr Ala Glu Glu Leu Asn Cys Cys Arg Asp Ala Val 
145                 150                 155                 160 


Leu Met Gln Phe Cys Ala Asn Lys Leu Asp Lys Lys Asp Phe Phe Gly 
                165                 170                 175     


Lys Ser Asp Pro Phe Leu Val Phe Tyr Arg Ser Asn Glu Asp Gly Ser 
            180                 185                 190         


Phe Thr Ile Cys His Lys Thr Glu Val Val Lys Asn Thr Leu Asn Pro 
        195                 200                 205             


Val Trp Gln Ala Phe Lys Ile Ser Val Arg Ala Leu Cys Asn Gly Asp 
    210                 215                 220                 


Tyr Asp Arg Thr Ile Lys Val Glu Val Tyr Asp Trp Asp Arg Asp Gly 
225                 230                 235                 240 


Ser His Asp Phe Ile Gly Glu Phe Thr Thr Ser Tyr Arg Glu Leu Ala 
                245                 250                 255     


Arg Gly Gln Ser Gln Phe Asn Val Tyr Glu Val Val Asn Pro Lys Lys 
            260                 265                 270         


Lys Gly Lys Lys Lys Lys Tyr Thr Asn Ser Gly Thr Val Thr Leu Leu 
        275                 280                 285             


Ser Phe Leu Val Glu Thr Glu Val Ser Phe Leu Asp Tyr Ile Lys Gly 
    290                 295                 300                 


Gly Thr Gln Ile Asn Phe Thr Val Ala Ile Asp Phe Thr Ala Ser Asn 
305                 310                 315                 320 


Gly Asn Pro Ala Gln Pro Thr Ser Leu His Tyr Met Asn Pro Tyr Gln 
                325                 330                 335     


Leu Asn Ala Tyr Gly Met Ala Leu Lys Ala Val Gly Glu Ile Val Gln 
            340                 345                 350         


Asp Tyr Asp Ser Asp Lys Met Phe Pro Ala Leu Gly Phe Gly Ala Lys 
        355                 360                 365             


Leu Pro Pro Asp Gly Arg Ile Ser His Glu Phe Ala Leu Asn Gly Asn 
    370                 375                 380                 


Pro Gln Asn Pro Tyr Cys Asp Gly Ile Glu Gly Val Met Glu Ala Tyr 
385                 390                 395                 400 


Tyr Arg Ser Leu Lys Ser Val Gln Leu Tyr Gly Pro Thr Asn Phe Ala 
                405                 410                 415     


Pro Val Ile Asn His Val Ala Arg Tyr Ala Ser Ser Val Lys Asp Gly 
            420                 425                 430         


Ser Gln Tyr Phe Val Leu Leu Ile Val Thr Asp Gly Val Ile Ser Asp 
        435                 440                 445             


Met Ala Gln Thr Lys Glu Ser Ile Val Asn Ala Ser Lys Leu Pro Met 
    450                 455                 460                 


Ser Ile Ile Ile Val Gly Val Gly Pro Ala Glu Phe Asp Ala Met Val 
465                 470                 475                 480 


Glu Leu Asp Gly Asp Asp Val Arg Val Ser Ser Arg Gly Lys Tyr Ala 
                485                 490                 495     


Glu Arg Asp Ile Val Gln Phe Val Pro Phe Arg Asp Tyr Ile Asp Arg 
            500                 505                 510         


Ser Gly Asn His Ile Leu Ser Met Ala Arg Leu Ala Lys Asp Val Leu 
        515                 520                 525             


Ala Glu Ile Pro Glu Gln Phe Leu Ser Tyr Met Arg Ala Arg Gly Ile 
    530                 535                 540                 


Lys Pro Ser Pro Ala Pro Pro Pro Tyr Thr Pro Pro Thr His Val Leu 
545                 550                 555                 560 


Gln Thr Gln Ile 
                


<210>  128
<211>  104
<212>  PRT
<213>  Mus musculus

<400>  128

Met Trp Ala Arg Asp Lys Cys Ser Val Pro Gln Leu Glu Met Asp Ser 
1               5                   10                  15      


Arg Tyr Thr Ser Ala Thr Gly Ile Gly Asp Leu Asn Gln Leu Ser Ala 
            20                  25                  30          


Ala Ile Pro Ala Thr Arg Val Glu Val Ser Val Ser Cys Arg Asn Leu 
        35                  40                  45              


Leu Asp Arg Asp Thr Phe Ser Lys Ser Asp Pro Ile Cys Val Leu Tyr 
    50                  55                  60                  


Thr Gln Ala Val Gly Asn Lys Glu Trp Arg Glu Glu Ala Ala Pro Leu 
65                  70                  75                  80  


Glu Glu Pro Leu His Arg Trp Glu Asn Ser Thr Gln Tyr Tyr Leu Val 
                85                  90                  95      


Arg Ala Leu His Ser Ala Leu Leu 
            100                 


<210>  129
<211>  2151
<212>  DNA
<213>  Mus musculus

<400>  129
aaagggctgg acggcggcgg cagcctcttg cctggctctg cggggctttc ctcccggcaa       60

gggctttgcc gaggtcactc gcgcgaggcc gctcttggcg cgcccgtggg aggctcggtg      120

gcgtgggagg accagcgacc tgcggatttc ctcgagctcc cacggcgctg gcagcgacgg      180

tcccccaccc ccacccctat ccccaggctt ccaccagaag gctccgcaag actcacggac      240

ctccaagtcc ccaggagagg agacaaggct caggagtcct gatctagctg tggccactgg      300

aagactctca ggccggggag cgtcatgtcc acctttgaag acgctgatac agaggagacg      360

gtcacttgtc tccagatgac catttaccat cctggccaac aaagtgggat atttaaatca      420

ataaggtttt gcagcaaaga gaagtttcct tccattgaag tggtgaaatt tggacgcaat      480

tccaacatgt gccagtatac gtttcaggac aaacaggtgt cccgaattca gtttgtttta      540

cagccgttta aacagttcaa cagctccgtt ctctcgtttg aaataaaaaa catgagcaag      600

aaaaccagtt tgatggtaga caaccaggag ctcggctacc tcaataaaat ggacctgcct      660

tacaagtgta tgctcaggtt cggagagtat cagttcctgt tgcagaagga agacggagag      720

tcggtggaat cttttgagac tcaatttatc atgtcttcaa gacctctctt gcaagaaaac      780

aactggccaa cacagaatcc cataccagag gatgggatgt attcttcata cttcacccac      840

agaagttctc cttcagaaat ggatgaaaac gaactgtgaa gagggtccaa ctggagacac      900

attgaaggat gaggacacat gggtcggatg tcaagagaca tcctacttcc gagtttgtga      960

gtgtagcgta gcgcggctgt cctcatgctg actttcgttt tggtaatagc atttggaagt     1020

ctctagactg tgttaatcat caacttagtc aactgagttt cggctctaca aagaattaag     1080

tgtacatctg taagggttgg tgcatcagac acgtcttctg ggtaatgagg tcacccttgt     1140

tgcttttctg catgatgtta cccccatgct ttgtcttggt ggcagccatc tcttggcccg     1200

gtcacatcat ttcgtagcag cctttgtttt tcaggtttag agctcgggca gattgctcac     1260

tggtgtctgt ggcgtgctag cgcttgtaga actagagtcc tggaataagt tctagagtgc     1320

tgagtcactg agtcaccatg gcttccttat ggaaagactt gggaaatagc tccttgattt     1380

tctttctgtg gaacggtagt gtcgctttcc tatatgtagg acctacaaca aacatttaaa     1440

gaacactgag atgaagatgg ttttcttaca atattgaaag tgaattttat gtatctcaca     1500

gatttaaaaa tggcagaaat caaaactttt aacagcctct ttgcacatga taaagccgga     1560

gcccagttcc ttagttgctt ctttggaact tcttaaagga aaacatgtat tcttaaagga     1620

aaacatctat tcttaggctg ccctatagaa gtcagtacct gtgaatattt atattaaatg     1680

cttaattatt tctaaaattt tagtttcaca taaagttgta tttatttaaa agattctcat     1740

tcacttcatt ttggctagat taagatgaat gttagtgaac attatgtaaa agaggatgaa     1800

agccattaag ttaagataaa ttctagcatt actagtaagt aaggcaccct gtatagcttc     1860

ctctgtaaat gaaatttaat gctgtaacag gtacaggatt ttgggtaggg gaggaggtca     1920

ggtgggggaa gttagccaca ttcatatttt gtttttgttt ttgtttttgt ttttgttttt     1980

gttttccaac aatagcttgc tttgaagctc aggctggctt ggaactcttg atcctcatac     2040

atcggccccc tgaatgctgt gcctagctta atgtaactgt atttctgcaa cagccctttg     2100

aaattatttc taataaactg tttggcctag taaaaaaaaa aaaaaaaaaa g              2151


<210>  130
<211>  184
<212>  PRT
<213>  Mus musculus

<400>  130

Met Ser Thr Phe Glu Asp Ala Asp Thr Glu Glu Thr Val Thr Cys Leu 
1               5                   10                  15      


Gln Met Thr Ile Tyr His Pro Gly Gln Gln Ser Gly Ile Phe Lys Ser 
            20                  25                  30          


Ile Arg Phe Cys Ser Lys Glu Lys Phe Pro Ser Ile Glu Val Val Lys 
        35                  40                  45              


Phe Gly Arg Asn Ser Asn Met Cys Gln Tyr Thr Phe Gln Asp Lys Gln 
    50                  55                  60                  


Val Ser Arg Ile Gln Phe Val Leu Gln Pro Phe Lys Gln Phe Asn Ser 
65                  70                  75                  80  


Ser Val Leu Ser Phe Glu Ile Lys Asn Met Ser Lys Lys Thr Ser Leu 
                85                  90                  95      


Met Val Asp Asn Gln Glu Leu Gly Tyr Leu Asn Lys Met Asp Leu Pro 
            100                 105                 110         


Tyr Lys Cys Met Leu Arg Phe Gly Glu Tyr Gln Phe Leu Leu Gln Lys 
        115                 120                 125             


Glu Asp Gly Glu Ser Val Glu Ser Phe Glu Thr Gln Phe Ile Met Ser 
    130                 135                 140                 


Ser Arg Pro Leu Leu Gln Glu Asn Asn Trp Pro Thr Gln Asn Pro Ile 
145                 150                 155                 160 


Pro Glu Asp Gly Met Tyr Ser Ser Tyr Phe Thr His Arg Ser Ser Pro 
                165                 170                 175     


Ser Glu Met Asp Glu Asn Glu Leu 
            180                 


<210>  131
<211>  9005
<212>  DNA
<213>  Mus musculus

<400>  131
agatggacag cagcctggca ggctggagga aggtgcatgt ccacctccaa ttactctcta       60

gagcaacaat ctgaagactg gaactgggct tcaagcacac aagtgtgttg gggtatccag      120

gactcgttga ggtgaaagtg ctgggttctg atgatggaac cccgcccgac cagaggctgg      180

gatctgttcg ggtccgggcc acccccgcca tcttcctttt gagcccagca gaggccacta      240

aggactccag agtgctctcc acaccacagg gcatcaggct cacctcggga acacggagcc      300

atggcaacag caaagtgttt cactgatgag cctcagctac aaagcagaag gaagcacaat      360

ctccaggaga tgctgacaga agtgggactg tctgttgact actggttacc taagcttcag      420

gaagatctgg gtgtcacctc ggcccaggcc ttacaatatt tagacaggaa tgacctccag      480

aagctgaagt cccagacaac acacacatgg gagaaaaggg cgctggagaa gttactggac      540

ttctcacagc caaacagtgt tgcagagcta caggagactc caagggagat gaaaaagaac      600

aggcagaggc aggcaggaca agcactgcag gctctgaaag ccttgcagtc agaagggaag      660

cacagagagg aagaggcagt gaggagaaaa gaagcagagc tgagacaagc aatggagatc      720

cctgaggagt gctggccaac ggctgaagtg tccctaaaag acatcactga aataatggag      780

agacatctca gtcacatgga acggaccctg gctcacagtc caaacctctc agatggagac      840

ctggtaagat gggcatctgg agggctggct ctgcagggaa tttataagac caaccaccca      900

agaagcctga ttcagaagag agaagagcta ctcagtgtcc ctaagcagtt ctcacttgtt      960

ggcccagaac atggcaccga aataaaaacg atggaatttt catcttttca cgaacaagcc     1020

atgtttacag agactataaa gatgatgggt ttcagttcaa cctccttggt taaaggcgaa     1080

ggatggggat ttagtctaga agctggtata gatcaaaacg aacagacagc atctgagaat     1140

acacaccaat cccattcaga gcaaacttat ttttgctcag ccaggttcag ctacatccca     1200

ttggccacgt gccattttca catcaatgat cttgaactct ccaatgctgc tctccaggaa     1260

ctaaaaacta ttgaagaact cctggagcag acaacagacc accgagatgg actaccctta     1320

ctaaggcaca gggctgaaaa ctttttccat aggtttggct ctcatgctaa ccaaggccct     1380

ctgcaactgg gtggaatcta ctgctggaaa gccatttcag aaggtttcaa aagtgagcac     1440

ttggctgatg taaagcagca aacaagagag tctttgaata tttacattat gggcagttat     1500

agtggctttg gagttaaagt cggtgcaagt gttaatatag caaactcaaa ttcagaaaca     1560

gcatcattca gtacaactca tctacactct caaaccaagg tacaactatc tgtagcccag     1620

ataggtggac cagcagaagc agatggaatt gcccagtgga cagctggcct tgtagttagc     1680

aatcaaacct ggtctgtcat tgatagggaa ctgcagttgg tacctatttg ggacatcatc     1740

ctgtctagcc acagaactga ttttaagaat gctcttcaag tggctaactg cctaaaagac     1800

aactacactg ctctgactga actagatgcc cagattcaag agggggaaga atttctgact     1860

gctagaaaag aagctaagct tttcatagag gatgtgaaat gctgggaggt ttctgatcct     1920

gaagaacaac ttacaaagtt attagatttt atgcaaacat tgagtcaaaa aataaaaagt     1980

tataacattt ggattaatac atgtctcact gattgggatc tgcagaattt tctaataaat     2040

actgtaaagt tctgcaaaac ttcacccact tataaaactc agtttattaa atctcagttg     2100

tgcatccttc tagaacctca tgtctacaaa gttacaaact ttcctgaggc acactccatc     2160

atacagtgga tcaatcagtc agagtatggg gaagagcaag tcaaaatcac ctcattttct     2220

gaattcatta agaccttaaa gaaaacccac aaatacctga tggaagtgaa tttcaaaaat     2280

gaggccccag aaacagtgga agaagcagaa agaacggcta catatgaggt caccacagct     2340

ctcagctcct tcttgaagta cctcaaagaa acagaacagc cagacatgca gctgctgctg     2400

ctttccattg cagctggtgc aggctatcag ttggtaaaca gtatttttca gcatcttctg     2460

gggtgtgatg agttaaactt cctcttggat caaatgcaaa gtaaccaaca caaataccaa     2520

gagcttaaaa atatttgcaa ctacagagcc caggcattcc tggtgctcac agctctaaga     2580

accacagttg aaatcacaga tatttctaca gaagagaaaa gacaacgttt ggcattaatt     2640

aaacaacata tggggacact gttgtctgaa gaagttgcac atgttctcac aaaacatgga     2700

gaacatcatg actgggaaag tctggagaat gatttgagac tactcattga gggggactat     2760

aaagccacca cccattactt acaaatggat gaggtaaaaa aacaattgca aagtctctgc     2820

catggaaaga aacagaccta taaacaaaaa agtaatgaaa acatcacaaa aggaatgata     2880

gaaaatggac ctttcctgaa attactccaa cgtctaggcc tagacaatta ctatccaaaa     2940

aggatgagca gagctgactt ccatctgatc tataagacct ctgtgtacaa ttcacagcca     3000

aggtctgaaa aggagcttcc attctatttc ctacaaaagc tactgatgtt ggattatggg     3060

ttcagacatc tgatagtcaa agatgatgaa aacataaaaa aacaaatctc cataggttcc     3120

tccaatcacg aaaatgaaga tattgatcca tatgacgatg tcattataga caatgatagt     3180

cctggctatc cttcagccac tgagtcctgg ccccacattc acccattgga tatccagatg     3240

accattttac actgtgcaga tgatcttacc aggcaatata ttttctctaa actttccatt     3300

tgtcattatg cactccccct tgtggtacca aatcccaaca cttctcagat tgaattttat     3360

ctttggtctc tcagacaaat taggaaaagt tggcaagatg caagtaaatc tccacaggac     3420

aagagctaca gtcacagaaa tcagcagatg tgtcgtgtct ctacccccat tgtgtccttc     3480

attagagttg gaaatgacct ctctgcttcc aaatctcaga tcatgaactc tcttctcagt     3540

aaacgtaaac atgacgtgtt ttttcacaga cactgcaaag gaagcaacaa acactgtctc     3600

ctgatgcagg gagtggtgga aatctgctgg ttctgtcctg ccggccaagg tgaggacacg     3660

tttgaaaatt gtctgacctt caccagtctt catggagatg caaaggaaca cacccaacaa     3720

ctcagcttcc tccaacatgt ctcttctatc attgtggtcc tcatgtcagt ttctgataac     3780

aataaagaaa accaaaagct tgtcagacac ctctggcagt catcaacacc tttgatctgc     3840

ttgattgatg acaaagaaaa ggccatagca aatacttctg gtaaaagaat gagaattggc     3900

atcaagaata gaaatgaggc agaattaaca gaggagctca ccaatgccat caaacatttt     3960

ctagagctct ctaacactgt tctcagttta gaggactgtt cacagacagc tagagagcta     4020

ggattcatta ttgatgaaga ccagagagac tgcaaggaag ccaaagaaaa ggctcagact     4080

gtaatggccc tcctggagga atacaagtta tctcagacaa aagaaaattt actacccctt     4140

caaggacaac tttggcacct ttggtgtaag aaagacaaag aattctatca tctgagagaa     4200

aaggggaatc ggagcatcga acaacacaag agtgagattg aaacacataa aagaaaaatt     4260

cgacgtcaac agttggaaaa agcctttcct ctcaatgatt taatgcgctc tgttctcgaa     4320

ctcctccaag actattcaga aacacataac aaactctacg ttttgcagtg gctcactctg     4380

ttttttgaca acctgacaat agatcacctg gacaaattac atgaaaggca gagatctttg     4440

tggttaagga tacaaacaga aaagcaaaga gcacagaaga gcaactctgt gcagaatcag     4500

atagaagcca tctccacaga gattcataac tgtactttag gaattgagca ccttctccga     4560

gaagttggcc agatctatga agctctggaa gaaacttcct cctctagaga tagccttttt     4620

ctctgcctcc ctcaaattgc tgcagacctg atgatagctg gtgttcccat tgagctgatg     4680

gacggggatg cttcatatgt gcctctaaag tgggtagcag ctatttttga caagatcaca     4740

gagaaagttg gagacaaaag gctgtttgtt ctctctgtcc ttggcctgca gagctcaggg     4800

aagtctaccc tactgaatgc cctgtttggc ctacagttca cagtcagtgc aggcaggtgt     4860

accaaggggg cctacatgca gctcctgaag gtggaagaga cattcacaga agaacttggc     4920

tttaattatg tgcttgttat agacacagaa ggacttcgag ctccagaact caacaacaaa     4980

tcccagaatt gggaccatga gttggcaaca ttagtcattg gccttggaaa cttgactctg     5040

atcaatattt ttggggagaa tccctcagac attcaggaca ttctacaaat atctgttcaa     5100

gcatttctga gaatgaaaca agtgaaaatc tcccccagtt gcctctttgt ccatcagaat     5160

gtgggagaag ttacagcaaa agaccaaact atggaaggac ggaagagact ggagcagaaa     5220

ctggatgaaa tgactgcatt ggctgctgag ttggaagagt gttccaacat aacccgcttc     5280

agtgatgtaa ttaagtttga tgccaatcga catgtctact actttgctca cctatgggat     5340

ggcaatcccc caatggctcc tcccaatcct cgctatagct acaatgtcca ggaactaagg     5400

aatgaaattc tttcaactgc ccagcaggaa tctaggggaa ggatcttgaa aatatcagat     5460

ttcaaattca gagttcaaga tttgtggaaa gcccttgtca gtgaaaactt cattttcagt     5520

ttcaggaaca cccaagaggt catagccatg agcaaactgg aaacaaagta taatgaatgg     5580

acctgggagc taaggagtca tgtactggac ttacagaatc agcttgacaa tcagattcaa     5640

aatggaaaaa tcctgacact cacatctaat ttactagagg aaccacttag caggaaactt     5700

aaaaccatca aagaagaatt tgacaaatat tttgaagaag acccagattg tgaaatattg     5760

gttcagtgga aagcaaattt tgaacacaag ttactaatcc ttaaagattc acttatttca     5820

gacaccagac agaaatgcaa tgaacatatc agtcttaaaa atagccaaga aatacttgat     5880

aaccaaaagt cacaatatga aaatcagttg ttagagagga gcagaaagtt agctttaaat     5940

ttgaagggta aggaattaag tgatgaagag ttgcatgaga aattcaggca actttggaca     6000

agttggattt atgatgtatc ttccaatgtt cctcatgtca cagagcctaa cattgatttg     6060

gactctgaaa atatccttct ggaatatttc aagaaggaca aaaatattgt ggaaagacta     6120

aaaataaagt ctcaaggaaa gtttgaaatc atgtatgaca aacatattca aatgaaaaag     6180

aaataccttt tacttagaaa gagtttagaa acctgtcatg ttgaatccat caaaaagaca     6240

accaacaaca ttcagttaaa atttacagaa acacttacaa acatttggaa acaaaagcgt     6300

gattacagtc agaattactt tcatgaaatc ttgaggatca tagaaaatga gctgaaatct     6360

gaaccctgtg agggagacta cacatttacc aaagactaca tcattgactt atccttgtac     6420

ttattccaaa gagcatccaa ggatttcaag aaaatgcacg cggcattcaa gactgcaaat     6480

gaccctgtga actatctgga gagaaagaaa gatgatttct ttatgagttt taagatctcc     6540

tgccaaggtg ccacttcaat cacttccttt gttgacttcc tatggctcaa gctcactcct     6600

gctatctctg tcagcatatg gaaaataatg gttcaaaaaa tagctggaga catgcgagcc     6660

acctgccctg aattcaatgg aaacagagct aacctggaga tacatattct ctactctcta     6720

gcagaagaag aaaaatttga taaatactgg aaatacattc aaaagccaga ggaatttttc     6780

agggattata ttagagacca cattaaaaga tactgttcag aaaaagagag tgaaaaaata     6840

aaaacttttt taaacataag cttaggtgac atcaagaata ctatcctgtc tgccattcat     6900

aactccacaa aggtagctaa agctaaaggc agcactgcat ctcactggct ggatttgttc     6960

tgtgaccacc tagggagcaa cctggtcttc ccaaggaaag acctggtaag catagagcac     7020

caggagctaa tggatactga gttcctcaaa gaagccatga gcaaagcttt ggatcctgca     7080

atgagggaag tagaagagga ttgttcaagt aagcacatag atgaaattgt tcctgacatt     7140

gagaaaattc tctctgaaca tctctgtggc tgttggaaac agtgtccttt ttgtaaggca     7200

atttgtacaa acaccattcc ccagcatgaa ggagaccaca gtgtgccatt ccaccgtcct     7260

caggctgtca gtggttggca ttggcataaa acagaccagt tccacattaa tgtttgtact     7320

agtagtgtag caagtaatat ttccttcatt ttagatggct tccgggaatt cccattcaag     7380

aaatatcgag aagcaggagg tgattatgcc acatggagca tcaccccaga ctcatctacc     7440

cagccatatt ggaaatggtt tgtctgtcat ttcagatcaa acctagaaga gaattatggc     7500

aaaaaattta cagggaaagg tagtcttcca gatttatgga ccaaaatcac aaagcaagaa     7560

gtcctgaatg acttaaaaaa ataataactg ccacagacag aacactagat gggccacaga     7620

aattttactt cagccaaggg agcctaatgg agaacaccat gcaggaggat ctgcagtaga     7680

catttgagct tcctcgatat ggcccactct attgggcaat ttttctgcag accaatatga     7740

agttaaactt tcataaaata agactgttta gatgaattaa tgattttata gaatttctga     7800

gttgatttaa atagttttag gcactagggt taatgataga aagtttaagg agatggctta     7860

atttgttctg ctaaatagat atgataaagt tagaattaag agcagaatgt gacctttccc     7920

ttgtaggata atgagagcta cataggtttg aaaaggagta cagtgagctt tcatgcattg     7980

caagtatgtg attgtacttg gaagaagaaa ataggcttgg gacaagttaa tgctcaaaac     8040

attcattcta ggttgggtct gagttcctgg attttgtgat ctagagacat agtcacaggt     8100

tttggtgggc accataaaaa ggcaaggtaa taaacaagga gtaaataatt cgattattag     8160

tatagaatag agaatagatg attctccagt atagctgaac aagactacaa aaataagatg     8220

taagagagat tgttccttcg taaatacaga ttgatcacca tctaagcata tggaaaactt     8280

gctactgtag acttggcttg cttaaacatt gttaatcaat aacaaaaaaa ttatagcttt     8340

aggtttgcta tggagaaaaa gatgagagaa cgttagatga gaaatgctta ggtatgagtt     8400

tcaaaagaga aatacacaat caatgctcct gttgtaatct cttgtgtgat gattttattg     8460

tcttattgaa gaacatgtgt tttgtgattg tttttagaaa acttgcaact tatggctatg     8520

aagtaatttt tgtcaaacat agagaacttt gtcttagatg gtgttaaaag gctaagagaa     8580

caataaagat gttagagctc acttgttgga gcttgcttca tcctccaagt gtatgagcat     8640

gtgccagctt tacattgtat acaatcacac atgccctctt tggatcattg acatagctag     8700

tcttcaacat cctcatacaa attgaagttg cattataaat taaataagta aaaataaatt     8760

agctactatt gcaagacttg aagattttct atgaaaatga ttttacttct ctctgattta     8820

ttatctaatg ctttattcat atatactaaa tatgttaatg atctattgtt ttgatttttt     8880

tttttttgct ttggttgttt tctgtttttg ttcttatgga agagtattgt tctcctgtat     8940

ttcttatttt ttgtttttta ttgtttgttt tgtttttatt tgaaagaaat aaaaataata     9000

gtaat                                                                 9005


<210>  132
<211>  2427
<212>  PRT
<213>  Mus musculus

<400>  132

Met Ala Thr Ala Lys Cys Phe Thr Asp Glu Pro Gln Leu Gln Ser Arg 
1               5                   10                  15      


Arg Lys His Asn Leu Gln Glu Met Leu Thr Glu Val Gly Leu Ser Val 
            20                  25                  30          


Asp Tyr Trp Leu Pro Lys Leu Gln Glu Asp Leu Gly Val Thr Ser Ala 
        35                  40                  45              


Gln Ala Leu Gln Tyr Leu Asp Arg Asn Asp Leu Gln Lys Leu Lys Ser 
    50                  55                  60                  


Gln Thr Thr His Thr Trp Glu Lys Arg Ala Leu Glu Lys Leu Leu Asp 
65                  70                  75                  80  


Phe Ser Gln Pro Asn Ser Val Ala Glu Leu Gln Glu Thr Pro Arg Glu 
                85                  90                  95      


Met Lys Lys Asn Arg Gln Arg Gln Ala Gly Gln Ala Leu Gln Ala Leu 
            100                 105                 110         


Lys Ala Leu Gln Ser Glu Gly Lys His Arg Glu Glu Glu Ala Val Arg 
        115                 120                 125             


Arg Lys Glu Ala Glu Leu Arg Gln Ala Met Glu Ile Pro Glu Glu Cys 
    130                 135                 140                 


Trp Pro Thr Ala Glu Val Ser Leu Lys Asp Ile Thr Glu Ile Met Glu 
145                 150                 155                 160 


Arg His Leu Ser His Met Glu Arg Thr Leu Ala His Ser Pro Asn Leu 
                165                 170                 175     


Ser Asp Gly Asp Leu Val Arg Trp Ala Ser Gly Gly Leu Ala Leu Gln 
            180                 185                 190         


Gly Ile Tyr Lys Thr Asn His Pro Arg Ser Leu Ile Gln Lys Arg Glu 
        195                 200                 205             


Glu Leu Leu Ser Val Pro Lys Gln Phe Ser Leu Val Gly Pro Glu His 
    210                 215                 220                 


Gly Thr Glu Ile Lys Thr Met Glu Phe Ser Ser Phe His Glu Gln Ala 
225                 230                 235                 240 


Met Phe Thr Glu Thr Ile Lys Met Met Gly Phe Ser Ser Thr Ser Leu 
                245                 250                 255     


Val Lys Gly Glu Gly Trp Gly Phe Ser Leu Glu Ala Gly Ile Asp Gln 
            260                 265                 270         


Asn Glu Gln Thr Ala Ser Glu Asn Thr His Gln Ser His Ser Glu Gln 
        275                 280                 285             


Thr Tyr Phe Cys Ser Ala Arg Phe Ser Tyr Ile Pro Leu Ala Thr Cys 
    290                 295                 300                 


His Phe His Ile Asn Asp Leu Glu Leu Ser Asn Ala Ala Leu Gln Glu 
305                 310                 315                 320 


Leu Lys Thr Ile Glu Glu Leu Leu Glu Gln Thr Thr Asp His Arg Asp 
                325                 330                 335     


Gly Leu Pro Leu Leu Arg His Arg Ala Glu Asn Phe Phe His Arg Phe 
            340                 345                 350         


Gly Ser His Ala Asn Gln Gly Pro Leu Gln Leu Gly Gly Ile Tyr Cys 
        355                 360                 365             


Trp Lys Ala Ile Ser Glu Gly Phe Lys Ser Glu His Leu Ala Asp Val 
    370                 375                 380                 


Lys Gln Gln Thr Arg Glu Ser Leu Asn Ile Tyr Ile Met Gly Ser Tyr 
385                 390                 395                 400 


Ser Gly Phe Gly Val Lys Val Gly Ala Ser Val Asn Ile Ala Asn Ser 
                405                 410                 415     


Asn Ser Glu Thr Ala Ser Phe Ser Thr Thr His Leu His Ser Gln Thr 
            420                 425                 430         


Lys Val Gln Leu Ser Val Ala Gln Ile Gly Gly Pro Ala Glu Ala Asp 
        435                 440                 445             


Gly Ile Ala Gln Trp Thr Ala Gly Leu Val Val Ser Asn Gln Thr Trp 
    450                 455                 460                 


Ser Val Ile Asp Arg Glu Leu Gln Leu Val Pro Ile Trp Asp Ile Ile 
465                 470                 475                 480 


Leu Ser Ser His Arg Thr Asp Phe Lys Asn Ala Leu Gln Val Ala Asn 
                485                 490                 495     


Cys Leu Lys Asp Asn Tyr Thr Ala Leu Thr Glu Leu Asp Ala Gln Ile 
            500                 505                 510         


Gln Glu Gly Glu Glu Phe Leu Thr Ala Arg Lys Glu Ala Lys Leu Phe 
        515                 520                 525             


Ile Glu Asp Val Lys Cys Trp Glu Val Ser Asp Pro Glu Glu Gln Leu 
    530                 535                 540                 


Thr Lys Leu Leu Asp Phe Met Gln Thr Leu Ser Gln Lys Ile Lys Ser 
545                 550                 555                 560 


Tyr Asn Ile Trp Ile Asn Thr Cys Leu Thr Asp Trp Asp Leu Gln Asn 
                565                 570                 575     


Phe Leu Ile Asn Thr Val Lys Phe Cys Lys Thr Ser Pro Thr Tyr Lys 
            580                 585                 590         


Thr Gln Phe Ile Lys Ser Gln Leu Cys Ile Leu Leu Glu Pro His Val 
        595                 600                 605             


Tyr Lys Val Thr Asn Phe Pro Glu Ala His Ser Ile Ile Gln Trp Ile 
    610                 615                 620                 


Asn Gln Ser Glu Tyr Gly Glu Glu Gln Val Lys Ile Thr Ser Phe Ser 
625                 630                 635                 640 


Glu Phe Ile Lys Thr Leu Lys Lys Thr His Lys Tyr Leu Met Glu Val 
                645                 650                 655     


Asn Phe Lys Asn Glu Ala Pro Glu Thr Val Glu Glu Ala Glu Arg Thr 
            660                 665                 670         


Ala Thr Tyr Glu Val Thr Thr Ala Leu Ser Ser Phe Leu Lys Tyr Leu 
        675                 680                 685             


Lys Glu Thr Glu Gln Pro Asp Met Gln Leu Leu Leu Leu Ser Ile Ala 
    690                 695                 700                 


Ala Gly Ala Gly Tyr Gln Leu Val Asn Ser Ile Phe Gln His Leu Leu 
705                 710                 715                 720 


Gly Cys Asp Glu Leu Asn Phe Leu Leu Asp Gln Met Gln Ser Asn Gln 
                725                 730                 735     


His Lys Tyr Gln Glu Leu Lys Asn Ile Cys Asn Tyr Arg Ala Gln Ala 
            740                 745                 750         


Phe Leu Val Leu Thr Ala Leu Arg Thr Thr Val Glu Ile Thr Asp Ile 
        755                 760                 765             


Ser Thr Glu Glu Lys Arg Gln Arg Leu Ala Leu Ile Lys Gln His Met 
    770                 775                 780                 


Gly Thr Leu Leu Ser Glu Glu Val Ala His Val Leu Thr Lys His Gly 
785                 790                 795                 800 


Glu His His Asp Trp Glu Ser Leu Glu Asn Asp Leu Arg Leu Leu Ile 
                805                 810                 815     


Glu Gly Asp Tyr Lys Ala Thr Thr His Tyr Leu Gln Met Asp Glu Val 
            820                 825                 830         


Lys Lys Gln Leu Gln Ser Leu Cys His Gly Lys Lys Gln Thr Tyr Lys 
        835                 840                 845             


Gln Lys Ser Asn Glu Asn Ile Thr Lys Gly Met Ile Glu Asn Gly Pro 
    850                 855                 860                 


Phe Leu Lys Leu Leu Gln Arg Leu Gly Leu Asp Asn Tyr Tyr Pro Lys 
865                 870                 875                 880 


Arg Met Ser Arg Ala Asp Phe His Leu Ile Tyr Lys Thr Ser Val Tyr 
                885                 890                 895     


Asn Ser Gln Pro Arg Ser Glu Lys Glu Leu Pro Phe Tyr Phe Leu Gln 
            900                 905                 910         


Lys Leu Leu Met Leu Asp Tyr Gly Phe Arg His Leu Ile Val Lys Asp 
        915                 920                 925             


Asp Glu Asn Ile Lys Lys Gln Ile Ser Ile Gly Ser Ser Asn His Glu 
    930                 935                 940                 


Asn Glu Asp Ile Asp Pro Tyr Asp Asp Val Ile Ile Asp Asn Asp Ser 
945                 950                 955                 960 


Pro Gly Tyr Pro Ser Ala Thr Glu Ser Trp Pro His Ile His Pro Leu 
                965                 970                 975     


Asp Ile Gln Met Thr Ile Leu His Cys Ala Asp Asp Leu Thr Arg Gln 
            980                 985                 990         


Tyr Ile Phe Ser Lys Leu Ser Ile  Cys His Tyr Ala Leu  Pro Leu Val 
        995                 1000                 1005             


Val Pro  Asn Pro Asn Thr Ser  Gln Ile Glu Phe Tyr  Leu Trp Ser 
    1010                 1015                 1020             


Leu Arg  Gln Ile Arg Lys Ser  Trp Gln Asp Ala Ser  Lys Ser Pro 
    1025                 1030                 1035             


Gln Asp  Lys Ser Tyr Ser His  Arg Asn Gln Gln Met  Cys Arg Val 
    1040                 1045                 1050             


Ser Thr  Pro Ile Val Ser Phe  Ile Arg Val Gly Asn  Asp Leu Ser 
    1055                 1060                 1065             


Ala Ser  Lys Ser Gln Ile Met  Asn Ser Leu Leu Ser  Lys Arg Lys 
    1070                 1075                 1080             


His Asp  Val Phe Phe His Arg  His Cys Lys Gly Ser  Asn Lys His 
    1085                 1090                 1095             


Cys Leu  Leu Met Gln Gly Val  Val Glu Ile Cys Trp  Phe Cys Pro 
    1100                 1105                 1110             


Ala Gly  Gln Gly Glu Asp Thr  Phe Glu Asn Cys Leu  Thr Phe Thr 
    1115                 1120                 1125             


Ser Leu  His Gly Asp Ala Lys  Glu His Thr Gln Gln  Leu Ser Phe 
    1130                 1135                 1140             


Leu Gln  His Val Ser Ser Ile  Ile Val Val Leu Met  Ser Val Ser 
    1145                 1150                 1155             


Asp Asn  Asn Lys Glu Asn Gln  Lys Leu Val Arg His  Leu Trp Gln 
    1160                 1165                 1170             


Ser Ser  Thr Pro Leu Ile Cys  Leu Ile Asp Asp Lys  Glu Lys Ala 
    1175                 1180                 1185             


Ile Ala  Asn Thr Ser Gly Lys  Arg Met Arg Ile Gly  Ile Lys Asn 
    1190                 1195                 1200             


Arg Asn  Glu Ala Glu Leu Thr  Glu Glu Leu Thr Asn  Ala Ile Lys 
    1205                 1210                 1215             


His Phe  Leu Glu Leu Ser Asn  Thr Val Leu Ser Leu  Glu Asp Cys 
    1220                 1225                 1230             


Ser Gln  Thr Ala Arg Glu Leu  Gly Phe Ile Ile Asp  Glu Asp Gln 
    1235                 1240                 1245             


Arg Asp  Cys Lys Glu Ala Lys  Glu Lys Ala Gln Thr  Val Met Ala 
    1250                 1255                 1260             


Leu Leu  Glu Glu Tyr Lys Leu  Ser Gln Thr Lys Glu  Asn Leu Leu 
    1265                 1270                 1275             


Pro Leu  Gln Gly Gln Leu Trp  His Leu Trp Cys Lys  Lys Asp Lys 
    1280                 1285                 1290             


Glu Phe  Tyr His Leu Arg Glu  Lys Gly Asn Arg Ser  Ile Glu Gln 
    1295                 1300                 1305             


His Lys  Ser Glu Ile Glu Thr  His Lys Arg Lys Ile  Arg Arg Gln 
    1310                 1315                 1320             


Gln Leu  Glu Lys Ala Phe Pro  Leu Asn Asp Leu Met  Arg Ser Val 
    1325                 1330                 1335             


Leu Glu  Leu Leu Gln Asp Tyr  Ser Glu Thr His Asn  Lys Leu Tyr 
    1340                 1345                 1350             


Val Leu  Gln Trp Leu Thr Leu  Phe Phe Asp Asn Leu  Thr Ile Asp 
    1355                 1360                 1365             


His Leu  Asp Lys Leu His Glu  Arg Gln Arg Ser Leu  Trp Leu Arg 
    1370                 1375                 1380             


Ile Gln  Thr Glu Lys Gln Arg  Ala Gln Lys Ser Asn  Ser Val Gln 
    1385                 1390                 1395             


Asn Gln  Ile Glu Ala Ile Ser  Thr Glu Ile His Asn  Cys Thr Leu 
    1400                 1405                 1410             


Gly Ile  Glu His Leu Leu Arg  Glu Val Gly Gln Ile  Tyr Glu Ala 
    1415                 1420                 1425             


Leu Glu  Glu Thr Ser Ser Ser  Arg Asp Ser Leu Phe  Leu Cys Leu 
    1430                 1435                 1440             


Pro Gln  Ile Ala Ala Asp Leu  Met Ile Ala Gly Val  Pro Ile Glu 
    1445                 1450                 1455             


Leu Met  Asp Gly Asp Ala Ser  Tyr Val Pro Leu Lys  Trp Val Ala 
    1460                 1465                 1470             


Ala Ile  Phe Asp Lys Ile Thr  Glu Lys Val Gly Asp  Lys Arg Leu 
    1475                 1480                 1485             


Phe Val  Leu Ser Val Leu Gly  Leu Gln Ser Ser Gly  Lys Ser Thr 
    1490                 1495                 1500             


Leu Leu  Asn Ala Leu Phe Gly  Leu Gln Phe Thr Val  Ser Ala Gly 
    1505                 1510                 1515             


Arg Cys  Thr Lys Gly Ala Tyr  Met Gln Leu Leu Lys  Val Glu Glu 
    1520                 1525                 1530             


Thr Phe  Thr Glu Glu Leu Gly  Phe Asn Tyr Val Leu  Val Ile Asp 
    1535                 1540                 1545             


Thr Glu  Gly Leu Arg Ala Pro  Glu Leu Asn Asn Lys  Ser Gln Asn 
    1550                 1555                 1560             


Trp Asp  His Glu Leu Ala Thr  Leu Val Ile Gly Leu  Gly Asn Leu 
    1565                 1570                 1575             


Thr Leu  Ile Asn Ile Phe Gly  Glu Asn Pro Ser Asp  Ile Gln Asp 
    1580                 1585                 1590             


Ile Leu  Gln Ile Ser Val Gln  Ala Phe Leu Arg Met  Lys Gln Val 
    1595                 1600                 1605             


Lys Ile  Ser Pro Ser Cys Leu  Phe Val His Gln Asn  Val Gly Glu 
    1610                 1615                 1620             


Val Thr  Ala Lys Asp Gln Thr  Met Glu Gly Arg Lys  Arg Leu Glu 
    1625                 1630                 1635             


Gln Lys  Leu Asp Glu Met Thr  Ala Leu Ala Ala Glu  Leu Glu Glu 
    1640                 1645                 1650             


Cys Ser  Asn Ile Thr Arg Phe  Ser Asp Val Ile Lys  Phe Asp Ala 
    1655                 1660                 1665             


Asn Arg  His Val Tyr Tyr Phe  Ala His Leu Trp Asp  Gly Asn Pro 
    1670                 1675                 1680             


Pro Met  Ala Pro Pro Asn Pro  Arg Tyr Ser Tyr Asn  Val Gln Glu 
    1685                 1690                 1695             


Leu Arg  Asn Glu Ile Leu Ser  Thr Ala Gln Gln Glu  Ser Arg Gly 
    1700                 1705                 1710             


Arg Ile  Leu Lys Ile Ser Asp  Phe Lys Phe Arg Val  Gln Asp Leu 
    1715                 1720                 1725             


Trp Lys  Ala Leu Val Ser Glu  Asn Phe Ile Phe Ser  Phe Arg Asn 
    1730                 1735                 1740             


Thr Gln  Glu Val Ile Ala Met  Ser Lys Leu Glu Thr  Lys Tyr Asn 
    1745                 1750                 1755             


Glu Trp  Thr Trp Glu Leu Arg  Ser His Val Leu Asp  Leu Gln Asn 
    1760                 1765                 1770             


Gln Leu  Asp Asn Gln Ile Gln  Asn Gly Lys Ile Leu  Thr Leu Thr 
    1775                 1780                 1785             


Ser Asn  Leu Leu Glu Glu Pro  Leu Ser Arg Lys Leu  Lys Thr Ile 
    1790                 1795                 1800             


Lys Glu  Glu Phe Asp Lys Tyr  Phe Glu Glu Asp Pro  Asp Cys Glu 
    1805                 1810                 1815             


Ile Leu  Val Gln Trp Lys Ala  Asn Phe Glu His Lys  Leu Leu Ile 
    1820                 1825                 1830             


Leu Lys  Asp Ser Leu Ile Ser  Asp Thr Arg Gln Lys  Cys Asn Glu 
    1835                 1840                 1845             


His Ile  Ser Leu Lys Asn Ser  Gln Glu Ile Leu Asp  Asn Gln Lys 
    1850                 1855                 1860             


Ser Gln  Tyr Glu Asn Gln Leu  Leu Glu Arg Ser Arg  Lys Leu Ala 
    1865                 1870                 1875             


Leu Asn  Leu Lys Gly Lys Glu  Leu Ser Asp Glu Glu  Leu His Glu 
    1880                 1885                 1890             


Lys Phe  Arg Gln Leu Trp Thr  Ser Trp Ile Tyr Asp  Val Ser Ser 
    1895                 1900                 1905             


Asn Val  Pro His Val Thr Glu  Pro Asn Ile Asp Leu  Asp Ser Glu 
    1910                 1915                 1920             


Asn Ile  Leu Leu Glu Tyr Phe  Lys Lys Asp Lys Asn  Ile Val Glu 
    1925                 1930                 1935             


Arg Leu  Lys Ile Lys Ser Gln  Gly Lys Phe Glu Ile  Met Tyr Asp 
    1940                 1945                 1950             


Lys His  Ile Gln Met Lys Lys  Lys Tyr Leu Leu Leu  Arg Lys Ser 
    1955                 1960                 1965             


Leu Glu  Thr Cys His Val Glu  Ser Ile Lys Lys Thr  Thr Asn Asn 
    1970                 1975                 1980             


Ile Gln  Leu Lys Phe Thr Glu  Thr Leu Thr Asn Ile  Trp Lys Gln 
    1985                 1990                 1995             


Lys Arg  Asp Tyr Ser Gln Asn  Tyr Phe His Glu Ile  Leu Arg Ile 
    2000                 2005                 2010             


Ile Glu  Asn Glu Leu Lys Ser  Glu Pro Cys Glu Gly  Asp Tyr Thr 
    2015                 2020                 2025             


Phe Thr  Lys Asp Tyr Ile Ile  Asp Leu Ser Leu Tyr  Leu Phe Gln 
    2030                 2035                 2040             


Arg Ala  Ser Lys Asp Phe Lys  Lys Met His Ala Ala  Phe Lys Thr 
    2045                 2050                 2055             


Ala Asn  Asp Pro Val Asn Tyr  Leu Glu Arg Lys Lys  Asp Asp Phe 
    2060                 2065                 2070             


Phe Met  Ser Phe Lys Ile Ser  Cys Gln Gly Ala Thr  Ser Ile Thr 
    2075                 2080                 2085             


Ser Phe  Val Asp Phe Leu Trp  Leu Lys Leu Thr Pro  Ala Ile Ser 
    2090                 2095                 2100             


Val Ser  Ile Trp Lys Ile Met  Val Gln Lys Ile Ala  Gly Asp Met 
    2105                 2110                 2115             


Arg Ala  Thr Cys Pro Glu Phe  Asn Gly Asn Arg Ala  Asn Leu Glu 
    2120                 2125                 2130             


Ile His  Ile Leu Tyr Ser Leu  Ala Glu Glu Glu Lys  Phe Asp Lys 
    2135                 2140                 2145             


Tyr Trp  Lys Tyr Ile Gln Lys  Pro Glu Glu Phe Phe  Arg Asp Tyr 
    2150                 2155                 2160             


Ile Arg  Asp His Ile Lys Arg  Tyr Cys Ser Glu Lys  Glu Ser Glu 
    2165                 2170                 2175             


Lys Ile  Lys Thr Phe Leu Asn  Ile Ser Leu Gly Asp  Ile Lys Asn 
    2180                 2185                 2190             


Thr Ile  Leu Ser Ala Ile His  Asn Ser Thr Lys Val  Ala Lys Ala 
    2195                 2200                 2205             


Lys Gly  Ser Thr Ala Ser His  Trp Leu Asp Leu Phe  Cys Asp His 
    2210                 2215                 2220             


Leu Gly  Ser Asn Leu Val Phe  Pro Arg Lys Asp Leu  Val Ser Ile 
    2225                 2230                 2235             


Glu His  Gln Glu Leu Met Asp  Thr Glu Phe Leu Lys  Glu Ala Met 
    2240                 2245                 2250             


Ser Lys  Ala Leu Asp Pro Ala  Met Arg Glu Val Glu  Glu Asp Cys 
    2255                 2260                 2265             


Ser Ser  Lys His Ile Asp Glu  Ile Val Pro Asp Ile  Glu Lys Ile 
    2270                 2275                 2280             


Leu Ser  Glu His Leu Cys Gly  Cys Trp Lys Gln Cys  Pro Phe Cys 
    2285                 2290                 2295             


Lys Ala  Ile Cys Thr Asn Thr  Ile Pro Gln His Glu  Gly Asp His 
    2300                 2305                 2310             


Ser Val  Pro Phe His Arg Pro  Gln Ala Val Ser Gly  Trp His Trp 
    2315                 2320                 2325             


His Lys  Thr Asp Gln Phe His  Ile Asn Val Cys Thr  Ser Ser Val 
    2330                 2335                 2340             


Ala Ser  Asn Ile Ser Phe Ile  Leu Asp Gly Phe Arg  Glu Phe Pro 
    2345                 2350                 2355             


Phe Lys  Lys Tyr Arg Glu Ala  Gly Gly Asp Tyr Ala  Thr Trp Ser 
    2360                 2365                 2370             


Ile Thr  Pro Asp Ser Ser Thr  Gln Pro Tyr Trp Lys  Trp Phe Val 
    2375                 2380                 2385             


Cys His  Phe Arg Ser Asn Leu  Glu Glu Asn Tyr Gly  Lys Lys Phe 
    2390                 2395                 2400             


Thr Gly  Lys Gly Ser Leu Pro  Asp Leu Trp Thr Lys  Ile Thr Lys 
    2405                 2410                 2415             


Gln Glu  Val Leu Asn Asp Leu  Lys Lys 
    2420                 2425         


<210>  133
<211>  4387
<212>  DNA
<213>  Mus musculus

<400>  133
tttccgctca gcaaggaacg cgagctggac ccccgacgag gcccggggct gacggagcga       60

ttgaattcct ctcttaaacg tctggatttt tttctttttc tttttttttt ttaaccagtg      120

gaaacttttt ctacctagtg gtcaatggct taatttgaac aagcgttgct gtggctttgg      180

ttccgctgtg cttttggaag cttgggtctg aaggatacag gtctttttgt gatgacaata      240

tgacccacag taaaggaaga cctgtcactt acaagacaag tgccagtccg gagagtggag      300

gaggttttgt agattggact ttaaatttaa atacaattca atctgacaag tttttgaact      360

tacttttaag catggtgcca gtcatttacc agaaaaatca ggaagacagg cataaaaaag      420

taaatggcat ctggcaggac gggctgtcgg gtgcagcaca gaccttcagc aagagatcag      480

agccacatct ggactaccac gagttctcag agcaagcctt ccacagcagc agcagtgggc      540

acactccagc cagctgcagc cccaagtacg atgactatgc tggctataac tactgtgacg      600

ggagggaggc ttcggaaacc accgccatgt tacaggacga agatctgtcc agcgagggcg      660

atgatgttat tgtggaaaca agccagagga ttccaaagga gtccagtggg gtcatggctc      720

tgcagatatt ggtgccattc ttgctggctg ggtttggaac ggtttctgct ggcatggttt      780

tggacatagt gcagcactgg gaggtgttca aaaatgtgac agaagtcttc attttggtcc      840

ccgcgcttct tggtcttaaa ggaaacttgg aaatgacgct ggcttctcga ttatctactg      900

cagtaaatgt tgggaagatg gactcaccca ttgagaagtg gaatctaatc attggcaact      960

tggctttaaa gcaggttcag gccacagtgg ttggcttttt agcagctgtg gcagccatca     1020

tactgggctg gattccagaa gggaagtatt acctcagcca ttccatactt ctgtgctcca     1080

gcagtgtggc aacggccttc atcgcatctc tactgcaggg aataataatg gttggtgtta     1140

tcgttggctc caagaagact ggcataaacc ctgacaacgt ggccacaccc attgctgcta     1200

gttttggtga tctgataact ctcgccatat tagcttggat aagtcagggt ttgtactcct     1260

gtcttgagac atattattac atttccccat tagtgtgtgc ctttttcttg gctctgactc     1320

ctatctggat tataatagct gccaagcacc cagctaccag gacagtgctc cactcaggct     1380

gggagcctgt cataacagcc atggttataa gcagcatcgg gggccttatt ctggacacaa     1440

ctgtatctga cccaaacttg gttgggattg ttgtttacac gccagttatc aacgggatcg     1500

gtggcaattt ggtggccatt caggctagca ggatttctac ctacctccat ttacatagca     1560

tccccggaga actacctgag gagcccaaag gctgttccta cccatttagg acattttttg     1620

gttcaggagt gaacaataag tctgcccagg ttctcctgct cttcgtgatc ccgggccact     1680

tgatcttcct ctacacaatt cacctgatga agagtggcca cacctctctg actgtagtct     1740

ttgttgttgt gtacctgttt gctgctgtgc tgcaggtgtt caccctgctg tggatcgccg     1800

actggatggt ccatcgcttc tggagaaaag gaaaggaccc agacagtttc tccatcccgt     1860

acctcacggc gctgggcgat ctgcttggga ctgctctgct ggccttaagc ttccattttc     1920

tctggctcat tggagaccga gatggagacg ttggagacta atgggaccta gaagctgtcg     1980

tggggtcaca caggggaagg atacaggcag ccattgctgc ccctccccaa agctcttcat     2040

ctgtcctgta acttatgcca gggtagtctg cagttcaccc tgactccgta aatggcctta     2100

atgtactttt taaggaattt gtgccgaaac cacaatgaat ggtatttgtg ctgctttttg     2160

tagaataaat aatttgacac agacatagat acaagctcac attctaaagt taattaggaa     2220

agaatttagg atgtttacaa tgagttaatt ttgaaaccac agacctagca gaaatagact     2280

ttattattaa gttataatgc acagttagag gcaagggagt gttagccttg tcttacagct     2340

gtgtcacact acagagtgcc atgactgatg tgacgggggc cagctgaacg tccctaagtg     2400

ttcattaggc cttcctccct gggagctaag gttaccagtt acttaactca caatacccct     2460

cccactgaac ataacaacca gctcactttt acccatatct aaaactgccc tgcgccaacg     2520

ttcatctctg ctcagcgagt tctcaacagc taacccttta gtagatttgt ttattctttc     2580

gtggagacag ggcttgctat gttgtccctg tagtcttttc acttgcagtc ccccttgctt     2640

tggctccctt ctcctggtgc taaaagcact gagctgtctc gctcatcctg tgttgaaaaa     2700

ggttgatccg atttagaaaa ccgtgattaa agcagaaggt gtgctgagct gtgtttgtgg     2760

gcccaagatg gagtgcgtgc gtgtgcgcat gtgtgaggga caggcccgag aaagacagag     2820

acaaagtagt ttctttctca aaaatgagta ccatttaata taatgcagac ctaggatctg     2880

ggacgtgcag gtggtcctgt tgccctttaa ggcgccctac ctgttggatg tcccaagttg     2940

gcggcttacc tcagcatcta ctgcatcagg gctccatctc ctgggaccgc ctcatggccg     3000

tggctgcgct cctcagatgt ctttctgaac gtaagcacct aacccctggc tattcagtag     3060

taagcacttt aaaattgccc ggcaatcgtt caaggccgtt aaatatttaa taatttaaac     3120

tgctgagggc atggactccg catgacgttg attgtcatgg cgaggttgtg ctggtgaaga     3180

actagcaggt agcttgtaaa tatactgagg aagtttctca ctaaatcttt atggaggctg     3240

tggtttagag ttgtatattt ttgcttattt ttaaacttcg ttcaattctc ctgccttata     3300

atcaaacatt taaggcatag aacggaatga attacaggat ctctcctttg gagagttagt     3360

gtcacggagt gaccattctg acaaaataag cataaagttt aagttgatga ataagtattt     3420

agttgcaaag attattttat ttaaaaatta atgaatacta cctttcattt tattataaaa     3480

gcatttgtga atttgggttt tgcatttggc tgtacattct tttggttttt gttttgtttt     3540

gttttgtttt gttttgtttt gttttgtttt tgagacagag tcttgcccag gcttaaactt     3600

cagctccacc tgccttagcc tgttgggatt cattttcttt aactcacaaa gagtatgcag     3660

agtaagcccc agtgttagcc tggttggcag tgttaggcat attcctaagc acgggaagat     3720

gtgtgagcta ccgtgtgtgg tgctgacagc ctcgcctggc aggtgggttg aatggagact     3780

cctgtctgtg ttttatcaag ggggaaatac agaggagtga catttgtaag atttcacagc     3840

tatgcaggga acagactctt cacatgtgtg tcccaccccc agatgtgcaa agggtctacc     3900

tagttagctg agaaaaagcc caatcaagtg ttactagtct tttagattgg cagcagggaa     3960

acctccacct agtgtggacc aactgtgaac tctccccgtt cctaaggtca gagagactgt     4020

atatgaacat ttaccttata aaatattttt tattttataa tgaagacctt tagactaaag     4080

aacaatgcct cgattcttca ggcctccaag agccagccct cttcctagat ctgctgtgtc     4140

aggcagtaga ggctttatcg gaacagcaaa atatctaaga cacatgtagt gggcagaaat     4200

agactcggac tgaatgcatt gtgaagggat atgcactgtt aattacagat ctttgaaagt     4260

ctctgtgtaa gtatgtaagt tttatttatc cataaaaagg taaatgaata atatttttat     4320

accacacaaa ccctgctttc caaaactggt ttcccactaa cttaccaggc acattataca     4380

cacagcc                                                               4387


<210>  134
<211>  573
<212>  PRT
<213>  Mus musculus

<400>  134

Met Thr His Ser Lys Gly Arg Pro Val Thr Tyr Lys Thr Ser Ala Ser 
1               5                   10                  15      


Pro Glu Ser Gly Gly Gly Phe Val Asp Trp Thr Leu Asn Leu Asn Thr 
            20                  25                  30          


Ile Gln Ser Asp Lys Phe Leu Asn Leu Leu Leu Ser Met Val Pro Val 
        35                  40                  45              


Ile Tyr Gln Lys Asn Gln Glu Asp Arg His Lys Lys Val Asn Gly Ile 
    50                  55                  60                  


Trp Gln Asp Gly Leu Ser Gly Ala Ala Gln Thr Phe Ser Lys Arg Ser 
65                  70                  75                  80  


Glu Pro His Leu Asp Tyr His Glu Phe Ser Glu Gln Ala Phe His Ser 
                85                  90                  95      


Ser Ser Ser Gly His Thr Pro Ala Ser Cys Ser Pro Lys Tyr Asp Asp 
            100                 105                 110         


Tyr Ala Gly Tyr Asn Tyr Cys Asp Gly Arg Glu Ala Ser Glu Thr Thr 
        115                 120                 125             


Ala Met Leu Gln Asp Glu Asp Leu Ser Ser Glu Gly Asp Asp Val Ile 
    130                 135                 140                 


Val Glu Thr Ser Gln Arg Ile Pro Lys Glu Ser Ser Gly Val Met Ala 
145                 150                 155                 160 


Leu Gln Ile Leu Val Pro Phe Leu Leu Ala Gly Phe Gly Thr Val Ser 
                165                 170                 175     


Ala Gly Met Val Leu Asp Ile Val Gln His Trp Glu Val Phe Lys Asn 
            180                 185                 190         


Val Thr Glu Val Phe Ile Leu Val Pro Ala Leu Leu Gly Leu Lys Gly 
        195                 200                 205             


Asn Leu Glu Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Val Asn Val 
    210                 215                 220                 


Gly Lys Met Asp Ser Pro Ile Glu Lys Trp Asn Leu Ile Ile Gly Asn 
225                 230                 235                 240 


Leu Ala Leu Lys Gln Val Gln Ala Thr Val Val Gly Phe Leu Ala Ala 
                245                 250                 255     


Val Ala Ala Ile Ile Leu Gly Trp Ile Pro Glu Gly Lys Tyr Tyr Leu 
            260                 265                 270         


Ser His Ser Ile Leu Leu Cys Ser Ser Ser Val Ala Thr Ala Phe Ile 
        275                 280                 285             


Ala Ser Leu Leu Gln Gly Ile Ile Met Val Gly Val Ile Val Gly Ser 
    290                 295                 300                 


Lys Lys Thr Gly Ile Asn Pro Asp Asn Val Ala Thr Pro Ile Ala Ala 
305                 310                 315                 320 


Ser Phe Gly Asp Leu Ile Thr Leu Ala Ile Leu Ala Trp Ile Ser Gln 
                325                 330                 335     


Gly Leu Tyr Ser Cys Leu Glu Thr Tyr Tyr Tyr Ile Ser Pro Leu Val 
            340                 345                 350         


Cys Ala Phe Phe Leu Ala Leu Thr Pro Ile Trp Ile Ile Ile Ala Ala 
        355                 360                 365             


Lys His Pro Ala Thr Arg Thr Val Leu His Ser Gly Trp Glu Pro Val 
    370                 375                 380                 


Ile Thr Ala Met Val Ile Ser Ser Ile Gly Gly Leu Ile Leu Asp Thr 
385                 390                 395                 400 


Thr Val Ser Asp Pro Asn Leu Val Gly Ile Val Val Tyr Thr Pro Val 
                405                 410                 415     


Ile Asn Gly Ile Gly Gly Asn Leu Val Ala Ile Gln Ala Ser Arg Ile 
            420                 425                 430         


Ser Thr Tyr Leu His Leu His Ser Ile Pro Gly Glu Leu Pro Glu Glu 
        435                 440                 445             


Pro Lys Gly Cys Ser Tyr Pro Phe Arg Thr Phe Phe Gly Ser Gly Val 
    450                 455                 460                 


Asn Asn Lys Ser Ala Gln Val Leu Leu Leu Phe Val Ile Pro Gly His 
465                 470                 475                 480 


Leu Ile Phe Leu Tyr Thr Ile His Leu Met Lys Ser Gly His Thr Ser 
                485                 490                 495     


Leu Thr Val Val Phe Val Val Val Tyr Leu Phe Ala Ala Val Leu Gln 
            500                 505                 510         


Val Phe Thr Leu Leu Trp Ile Ala Asp Trp Met Val His Arg Phe Trp 
        515                 520                 525             


Arg Lys Gly Lys Asp Pro Asp Ser Phe Ser Ile Pro Tyr Leu Thr Ala 
    530                 535                 540                 


Leu Gly Asp Leu Leu Gly Thr Ala Leu Leu Ala Leu Ser Phe His Phe 
545                 550                 555                 560 


Leu Trp Leu Ile Gly Asp Arg Asp Gly Asp Val Gly Asp 
                565                 570             


<210>  135
<211>  1252
<212>  DNA
<213>  Mus musculus

<400>  135
agagtgctga gcggatgcac gctcagcttt taggtgtaag ccgcaaacat cttggacccc       60

gggagaatcc gcgttgaaga acagagcatt tagctcctct gtcagaatga atgggaacca      120

gaaattggat gcttataacc aagaaaagca gaatttcatc cagcacttct cccagatcgt      180

caaggtgctg actgagaagg agctgggaca cccagagata ggggatgcta ttgcccggct      240

caaggaggtc ctagagtaca atgccttagg aggcaagtac aaccggggtt tgaccgtggt      300

acaagccttc caggagctgg tggagccgaa gaaacaggat gctgagagtc ttcagcgggc      360

cctgacagtg ggctggtgtg tagaactgct ccaggctttc ttccttgtgt cagatgacat      420

catggactct tccctcactc gccggggaca gatctgctgg tatcagaagc caggcatagg      480

cttggatgcc atcaacgacg ctctgcttct ggaagcctcc atctatcgtt tgctgaagtt      540

ctactgcagg gagcagccct actacctgaa cctgctggag ctctttctgc agagttccta      600

tcagacagag atcgggcaga ctctagacct catgacagca ccccagggcc atgtggatct      660

tggtagatac actgaaaaga ggtacaaatc gattgtcaag tacaagacgg ctttctactc      720

tttctacctg cctattgcgg ccgccatgta catggcaggc attgatgggg agaaggaaca      780

cgccaatgcc ctgaagatcc tgatggagat gggcgagttc ttccaggtcc aggacgacta      840

ccttgatctc tttggagacc ccagtgtgac gggaaaggtc ggcactgaca tccaggacaa      900

caaatgcagc tggctggtgg ttcagtgtct gctacgagcc tctcctcaac agcgccagat      960

cttagaggag aattatgggc agaaggaccc agaaaaagtg gctcgggtga aagcactgta     1020

tgaggcgctg gatctgcagt ctgctttctt caagtatgag gaagacagtt acaaccgcct     1080

caagagtctc atagagcagt gctctgcgcc cctgccccca tccatcttca tggaacttgc     1140

aaacaagatc tacaaacgga gaaagtgacc ccggaattgg agaggctggg agggaggggg     1200

tctcaataaa ttattgttca gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1252


<210>  136
<211>  353
<212>  PRT
<213>  Mus musculus

<400>  136

Met Asn Gly Asn Gln Lys Leu Asp Ala Tyr Asn Gln Glu Lys Gln Asn 
1               5                   10                  15      


Phe Ile Gln His Phe Ser Gln Ile Val Lys Val Leu Thr Glu Lys Glu 
            20                  25                  30          


Leu Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys Glu Val 
        35                  40                  45              


Leu Glu Tyr Asn Ala Leu Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
    50                  55                  60                  


Val Gln Ala Phe Gln Glu Leu Val Glu Pro Lys Lys Gln Asp Ala Glu 
65                  70                  75                  80  


Ser Leu Gln Arg Ala Leu Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                85                  90                  95      


Ala Phe Phe Leu Val Ser Asp Asp Ile Met Asp Ser Ser Leu Thr Arg 
            100                 105                 110         


Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Ile Gly Leu Asp Ala 
        115                 120                 125             


Ile Asn Asp Ala Leu Leu Leu Glu Ala Ser Ile Tyr Arg Leu Leu Lys 
    130                 135                 140                 


Phe Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Leu Glu Leu Phe 
145                 150                 155                 160 


Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Met 
                165                 170                 175     


Thr Ala Pro Gln Gly His Val Asp Leu Gly Arg Tyr Thr Glu Lys Arg 
            180                 185                 190         


Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
        195                 200                 205             


Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
    210                 215                 220                 


His Ala Asn Ala Leu Lys Ile Leu Met Glu Met Gly Glu Phe Phe Gln 
225                 230                 235                 240 


Val Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                245                 250                 255     


Lys Val Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
            260                 265                 270         


Gln Cys Leu Leu Arg Ala Ser Pro Gln Gln Arg Gln Ile Leu Glu Glu 
        275                 280                 285             


Asn Tyr Gly Gln Lys Asp Pro Glu Lys Val Ala Arg Val Lys Ala Leu 
    290                 295                 300                 


Tyr Glu Ala Leu Asp Leu Gln Ser Ala Phe Phe Lys Tyr Glu Glu Asp 
305                 310                 315                 320 


Ser Tyr Asn Arg Leu Lys Ser Leu Ile Glu Gln Cys Ser Ala Pro Leu 
                325                 330                 335     


Pro Pro Ser Ile Phe Met Glu Leu Ala Asn Lys Ile Tyr Lys Arg Arg 
            340                 345                 350         


Lys 
    


<210>  137
<211>  2494
<212>  DNA
<213>  Mus musculus

<400>  137
ccggaatctc tgtgttctag gtcagatcag acattctgtc acaatgcctg aaataaatac       60

cagccatctt gatgaaaaac aggttcagct tctagcggag atgtgtattc ttattgatga      120

aaatgacaat aaaattgggg ctgacaccaa gaaaaactgt caccttaatg aaaacatcga      180

caaaggatta ttacatcgag cttttagtgt cttcttgttt aatactgaaa ataagctcct      240

gttacagcag agatcagatg ctaaaattac ctttccaggt tgtttcacca atagttgctg      300

tagtcatcca ttaagtaacc caggcgagct ggaagagaac aacgccattg gtgtgaagcg      360

agcagcaaag cggcgcttga aagccgagtt gggaataccc ttggaagagg ttgatctaaa      420

tgaaatggat tatctaacaa gaatttacta caaggcccaa tctgatggta tctggggtga      480

acatgaagtt gattacattc tgtttctgag gaagaatgta accttgaatc cagatcccaa      540

cgagattaaa agctattgct atgtatcaaa ggaagaagtc agagaaattt tgaagaaggc      600

agccagtggt gaaattaagt taactccgtg gtttaagata attgcagata ctttcctctt      660

caaatggtgg gataacttaa accatttgag tccatttgtt gaccatgaga aaatacatag      720

attgtgaatg tgtaaatgat ttgaaaaatt ttctacctgg taagaatggt ttggtttggt      780

tttaaattgg gccctcttat atgatacata ggtattttac aaccagaatt tgttttgaga      840

aaagaaaaac tcaactagct tacagtttta tatcatatat cccatatata tgcactgatg      900

tctgtaaaag atatttaggt gaggttattg caaaattatg ccataagtaa aacttaattt      960

agcctgtcca aatacctggc tatgacaaga ttgaggaagt aactagaact catattttac     1020

atttgataga cactttcaga actctttgct aattgtcaag tgttgtttat atctttagat     1080

ttttatcata catcagaaaa ttgagcagct gctttgaaac agcactaaga ggttaaatgg     1140

gcagggctca ggagacagct cagtgtacca tgattgcctt gcaggcatga tgtcatgggt     1200

tgttgagtcc ctaaccctaa agataattgt aacaacagca gcaacaggca gagcaggttc     1260

agagggaagt atatggcgct ctctctctct ctctctctct ctctctctct ctctctctct     1320

ctctctctct ctgtctcggt cttcagacag gatgattaat ctcaggaacc ctgtataacc     1380

aatactggat gctcaagtcg atagaacgta tcgtatttgc atattactga ctacacttca     1440

cctcgtctct ggcgtggcca tgacactcaa cccagcgtaa atgctcctgt aaatgatagt     1500

tgtactatgc tttatgataa ggagacgtct gcatgtgcgg cacagatcaa atattaatag     1560

acagttgctt gagcccttgg atgtttggcc cacagattta aaaggccagt tctgtatact     1620

aatttttgtc attctcactt gattttgtgc tttaaccatc ctgaaattat tattttacta     1680

cttaaaggta actgttactt ttggtagtaa tggtaactga ttagctattc agcaaaatct     1740

gtttatagtc ctagtgaaaa agatggttag tcataatgtg tgagtgagtt ctactttaaa     1800

aagttgagaa aacctttgac tctaccatgg ctggccctgg atcctcttgt tgtagggggt     1860

ctggcttgag ttagataatt tagtagcatt agcacccctt tttaagacaa caacaacaaa     1920

agaaaatcta gggaagagtg ggggcgtgtt tctttctctg tgtagctctg gctattctag     1980

aactcaattt gtagactagg ctagcctcaa aacccagaga tccaccttcc tctgactccc     2040

aggtactggg attaaaggag tgtaccacat ggccagcaac aaccagaatt tgaatgggtg     2100

ataatcaaga gtcccgtaac gggctcgctg ttctatgatc agggcttatt ttagaggtgg     2160

aagtgggaag gagtagggct gaggaaacat acagtgacta gactgatgtc ccagaatagg     2220

catatattaa gattttgagg ttatagaata ggcatatatt gatactgtgt tttgattgat     2280

gttcttttaa aacttgccac aggtgtgtca catttgagct ctttagacag ctttattctt     2340

aagtgctgca taatggatac attttttctt ataaaaattt tataaaccta atttcttgct     2400

aactctgaac agttgattta tcattgggga tatgactatg ttgcaagaat ttattgaaaa     2460

ttaaaaataa attattttaa aaaaaaaaaa aaaa                                 2494


<210>  138
<211>  227
<212>  PRT
<213>  Mus musculus

<400>  138

Met Pro Glu Ile Asn Thr Ser His Leu Asp Glu Lys Gln Val Gln Leu 
1               5                   10                  15      


Leu Ala Glu Met Cys Ile Leu Ile Asp Glu Asn Asp Asn Lys Ile Gly 
            20                  25                  30          


Ala Asp Thr Lys Lys Asn Cys His Leu Asn Glu Asn Ile Asp Lys Gly 
        35                  40                  45              


Leu Leu His Arg Ala Phe Ser Val Phe Leu Phe Asn Thr Glu Asn Lys 
    50                  55                  60                  


Leu Leu Leu Gln Gln Arg Ser Asp Ala Lys Ile Thr Phe Pro Gly Cys 
65                  70                  75                  80  


Phe Thr Asn Ser Cys Cys Ser His Pro Leu Ser Asn Pro Gly Glu Leu 
                85                  90                  95      


Glu Glu Asn Asn Ala Ile Gly Val Lys Arg Ala Ala Lys Arg Arg Leu 
            100                 105                 110         


Lys Ala Glu Leu Gly Ile Pro Leu Glu Glu Val Asp Leu Asn Glu Met 
        115                 120                 125             


Asp Tyr Leu Thr Arg Ile Tyr Tyr Lys Ala Gln Ser Asp Gly Ile Trp 
    130                 135                 140                 


Gly Glu His Glu Val Asp Tyr Ile Leu Phe Leu Arg Lys Asn Val Thr 
145                 150                 155                 160 


Leu Asn Pro Asp Pro Asn Glu Ile Lys Ser Tyr Cys Tyr Val Ser Lys 
                165                 170                 175     


Glu Glu Val Arg Glu Ile Leu Lys Lys Ala Ala Ser Gly Glu Ile Lys 
            180                 185                 190         


Leu Thr Pro Trp Phe Lys Ile Ile Ala Asp Thr Phe Leu Phe Lys Trp 
        195                 200                 205             


Trp Asp Asn Leu Asn His Leu Ser Pro Phe Val Asp His Glu Lys Ile 
    210                 215                 220                 


His Arg Leu 
225         


<210>  139
<211>  2779
<212>  DNA
<213>  Mus musculus

<400>  139
gcgagcgggg cgcgcagcgg ttactctggt tactgtccgc gagggatgct ggggacccgg       60

cgggcaggag ccttcgcctc gctctgaagg acgctcatcc gagacagcca ttcactctcg      120

aggaaggcaa gtgtcggtcg gacaggttcc cggccgtgac ttcggggctt gcttgaggag      180

gaatctccaa gggagggctg agctgccagg ctgccgccgc gcttcgggac gccgtggcca      240

tcttttgttg gagaaggctg ccggggcagt gttgctaagg gcagctttcc cagcacccag      300

atccttctac gctcccgact ccttcctacc gagcacctgc tgctggtgac aaaagaccgt      360

ttacagccag gcgagcggac atcgaagtat acagccacat tcgcacccct cagcccaata      420

gagaggcccg tgtccatcag ttggctgaat gaagaagtgt gtaatcagga gccgttgggg      480

taggcaggct ttaaatgctg ccttttaaga tctggacaac ttaagataca tttgcactct      540

caatgatttc aaaaattgat cacatctgac tcgtgatcct gaaactattt attggaagaa      600

gttcgaccgg ttgccccgaa cccctttgag aactacattt tggggacatt ttaatcactg      660

aagaccttcc gaggaaaaaa gaccccccca agagaccccc aaaacacaaa atcctcagcc      720

ttggctggtg ccaccaaaga agccttttga gccatgtgga cttttcttgg cattgctacc      780

ttcacctatt tttataagaa atgcggggat gtcaccctgg ccaacaagga gctcctgctg      840

tgcgtgctgg tgttcctgtc gctgggcctg gtgctctcct accgctgtcg ccatcgacac      900

gggggcctcc ttggccgcca tcagagcggc gcccagttcg ctgccttctc ggatattctc      960

tctgctttgc ctcttattgg cttcttctgg gccaagtcac ctgaatcaga aaagaaagaa     1020

cagctggagt ccaagaagtg cagaaaagaa atcggtcttt cagaaacgac attaacagga     1080

gcagctacct cagtgtcgac ctcgttcgtg acggacccgg aagtgatcat cgtgggatct     1140

ggtgtgcttg gatctgcctt ggcagcagtt ctctccagag atggaagaaa ggtgacggtc     1200

atcgagagag atttaaaaga gcccgacagg atagttgggg agctgctgca gccaggaggc     1260

taccgtgttc tccaggagct gggccttgga gatacagtag aaggtctcaa tgcccatcat     1320

atacatggct acatagttca tgactatgaa agcagatctg aagttcaaat tccgtaccca     1380

ctgtcagaaa ccaaccaagt gcagagtgga attgcttttc accatggccg attcatcatg     1440

agtctccgga aagcagctat ggcagagccc aatgtaaagt ttatagaagg tgttgtgctt     1500

cagttactag aggaagatga tgctgtaatc ggcgtgcaat acaaggacaa ggagactggg     1560

gacaccaagg agctccacgc cccgctcacc gttgttgcgg atggactctt ctccaagttc     1620

aggaagagcc tcatctccag taaagtctcc gtttcttccc acttcgttgg cttccttatg     1680

aaggatgcac cacagtttaa acccaatttt gcggagcttg ttctggtcaa ccccagtcca     1740

gttctcatct accagatttc ttccagtgaa actagggtac ttgttgatat tcggggagaa     1800

ttgccaagaa acctaagaga atacatggct gaacaaattt acccacagtt acctgagcac     1860

ctgaaggagt catttctgga ggcctctcag aatggtcgtc tgcggaccat gccggccagc     1920

ttccttcctc cttcctcagt gaacaaacga ggcgtcctta ttctgggaga tgcgtataac     1980

ctgaggcacc ctcttactgg tggaggaatg acagttgctt taaaagatat aaaattgtgg     2040

agacaactgt taaaagacat tcctgacctt tatgatgatg ctgctatttt ccaggccaaa     2100

aaatcattct tttggtcaag aaaaaggacc cattcctttg ttgtgaatgt attggctcag     2160

gccttgtatg aattattttc agctacagat gattccttgc atcagctccg aaaagcttgc     2220

tttctgtatt ttaaacttgg tggagagtgt gtgaccggtc ctgttgggtt gctttcaata     2280

ttgtctcctc accctctggt gttgattcga cacttctttt ccgttgcaat ctacgccacg     2340

tatttctgct tcaaatcaga gccgtgggcg acaaaaccac gggccctttt cagtagcggt     2400

gctgtactgt acaaagcgtg ttctatccta tttccactca tctattcaga aatgaagtat     2460

ctggttcatt gaaagggagt ccacgtgcag tcaagtccct tggggcttga agaggatgta     2520

tatagcatag aactgtgtca cttccacagt ggacttgagg accaagcttg tgtataagca     2580

tgtaaatata agccttactt tacagttgaa aatgaaggtc agagaagcta gatgtttaaa     2640

aggatgattg tttctacaaa tcagtgctaa cactcaagtt tttcttttga tttcagtatt     2700

tggggtgact cattgggaca agccaataaa atgaagagtg aactcttaaa aaaaaaaaaa     2760

aaaaaaaaaa aaaaaaaaa                                                  2779


<210>  140
<211>  572
<212>  PRT
<213>  Mus musculus

<400>  140

Met Trp Thr Phe Leu Gly Ile Ala Thr Phe Thr Tyr Phe Tyr Lys Lys 
1               5                   10                  15      


Cys Gly Asp Val Thr Leu Ala Asn Lys Glu Leu Leu Leu Cys Val Leu 
            20                  25                  30          


Val Phe Leu Ser Leu Gly Leu Val Leu Ser Tyr Arg Cys Arg His Arg 
        35                  40                  45              


His Gly Gly Leu Leu Gly Arg His Gln Ser Gly Ala Gln Phe Ala Ala 
    50                  55                  60                  


Phe Ser Asp Ile Leu Ser Ala Leu Pro Leu Ile Gly Phe Phe Trp Ala 
65                  70                  75                  80  


Lys Ser Pro Glu Ser Glu Lys Lys Glu Gln Leu Glu Ser Lys Lys Cys 
                85                  90                  95      


Arg Lys Glu Ile Gly Leu Ser Glu Thr Thr Leu Thr Gly Ala Ala Thr 
            100                 105                 110         


Ser Val Ser Thr Ser Phe Val Thr Asp Pro Glu Val Ile Ile Val Gly 
        115                 120                 125             


Ser Gly Val Leu Gly Ser Ala Leu Ala Ala Val Leu Ser Arg Asp Gly 
    130                 135                 140                 


Arg Lys Val Thr Val Ile Glu Arg Asp Leu Lys Glu Pro Asp Arg Ile 
145                 150                 155                 160 


Val Gly Glu Leu Leu Gln Pro Gly Gly Tyr Arg Val Leu Gln Glu Leu 
                165                 170                 175     


Gly Leu Gly Asp Thr Val Glu Gly Leu Asn Ala His His Ile His Gly 
            180                 185                 190         


Tyr Ile Val His Asp Tyr Glu Ser Arg Ser Glu Val Gln Ile Pro Tyr 
        195                 200                 205             


Pro Leu Ser Glu Thr Asn Gln Val Gln Ser Gly Ile Ala Phe His His 
    210                 215                 220                 


Gly Arg Phe Ile Met Ser Leu Arg Lys Ala Ala Met Ala Glu Pro Asn 
225                 230                 235                 240 


Val Lys Phe Ile Glu Gly Val Val Leu Gln Leu Leu Glu Glu Asp Asp 
                245                 250                 255     


Ala Val Ile Gly Val Gln Tyr Lys Asp Lys Glu Thr Gly Asp Thr Lys 
            260                 265                 270         


Glu Leu His Ala Pro Leu Thr Val Val Ala Asp Gly Leu Phe Ser Lys 
        275                 280                 285             


Phe Arg Lys Ser Leu Ile Ser Ser Lys Val Ser Val Ser Ser His Phe 
    290                 295                 300                 


Val Gly Phe Leu Met Lys Asp Ala Pro Gln Phe Lys Pro Asn Phe Ala 
305                 310                 315                 320 


Glu Leu Val Leu Val Asn Pro Ser Pro Val Leu Ile Tyr Gln Ile Ser 
                325                 330                 335     


Ser Ser Glu Thr Arg Val Leu Val Asp Ile Arg Gly Glu Leu Pro Arg 
            340                 345                 350         


Asn Leu Arg Glu Tyr Met Ala Glu Gln Ile Tyr Pro Gln Leu Pro Glu 
        355                 360                 365             


His Leu Lys Glu Ser Phe Leu Glu Ala Ser Gln Asn Gly Arg Leu Arg 
    370                 375                 380                 


Thr Met Pro Ala Ser Phe Leu Pro Pro Ser Ser Val Asn Lys Arg Gly 
385                 390                 395                 400 


Val Leu Ile Leu Gly Asp Ala Tyr Asn Leu Arg His Pro Leu Thr Gly 
                405                 410                 415     


Gly Gly Met Thr Val Ala Leu Lys Asp Ile Lys Leu Trp Arg Gln Leu 
            420                 425                 430         


Leu Lys Asp Ile Pro Asp Leu Tyr Asp Asp Ala Ala Ile Phe Gln Ala 
        435                 440                 445             


Lys Lys Ser Phe Phe Trp Ser Arg Lys Arg Thr His Ser Phe Val Val 
    450                 455                 460                 


Asn Val Leu Ala Gln Ala Leu Tyr Glu Leu Phe Ser Ala Thr Asp Asp 
465                 470                 475                 480 


Ser Leu His Gln Leu Arg Lys Ala Cys Phe Leu Tyr Phe Lys Leu Gly 
                485                 490                 495     


Gly Glu Cys Val Thr Gly Pro Val Gly Leu Leu Ser Ile Leu Ser Pro 
            500                 505                 510         


His Pro Leu Val Leu Ile Arg His Phe Phe Ser Val Ala Ile Tyr Ala 
        515                 520                 525             


Thr Tyr Phe Cys Phe Lys Ser Glu Pro Trp Ala Thr Lys Pro Arg Ala 
    530                 535                 540                 


Leu Phe Ser Ser Gly Ala Val Leu Tyr Lys Ala Cys Ser Ile Leu Phe 
545                 550                 555                 560 


Pro Leu Ile Tyr Ser Glu Met Lys Tyr Leu Val His 
                565                 570         


<210>  141
<211>  402
<212>  DNA
<213>  Mus musculus

<400>  141
cccgtcttca agacatcgtt tgaaaggaaa tctttcgtga caatgccgtc tgaactggag       60

aaggccttga gcaacctcat tgatgtctac cacaattatt ccaatataca aggaaatcac      120

catgccctct acaagaatga cttcaagaaa atggtcacta ctgagtgtcc tcagtttgtg      180

cagaatataa atatcgaaaa cttgttcaga gaattggaca tcaatagtga caatgcaatt      240

aacttcgagg agttccttgc gatggtgata aaagtgggtg tggcatctca caaagacagc      300

cacaaggagt agcagagctt ctggcctagg gctgggtccc tggatatgtc tacagaataa      360

agtcatcata tctcaggtca aaaaaaaaaa aaaaaaaaaa aa                         402


<210>  142
<211>  88
<212>  PRT
<213>  Mus musculus

<400>  142

Pro Ser Glu Leu Glu Lys Ala Leu Ser Asn Leu Ile Asp Val Tyr His 
1               5                   10                  15      


Asn Tyr Ser Asn Ile Gln Gly Asn His His Ala Leu Tyr Lys Asn Asp 
            20                  25                  30          


Phe Lys Lys Met Val Thr Thr Glu Cys Pro Gln Phe Val Gln Asn Ile 
        35                  40                  45              


Asn Ile Glu Asn Leu Phe Arg Glu Leu Asp Ile Asn Ser Asp Asn Ala 
    50                  55                  60                  


Ile Asn Phe Glu Glu Phe Leu Ala Met Val Ile Lys Val Gly Val Ala 
65                  70                  75                  80  


Ser His Lys Asp Ser His Lys Glu 
                85              


<210>  143
<211>  488
<212>  DNA
<213>  Mus musculus

<400>  143
aacatctgtg actctttagc cttgagcaag aagatggcca acaaagcacc ttctcagatg       60

gagcgcagca taaccaccat catcgacacc ttccatcaat actctaggaa ggaaggacac      120

cctgacaccc tgagcaagaa ggaattcaga caaatggtgg aagcacagtt ggcaaccttt      180

atgaagaaag agaagagaaa tgaagccctc ataaatgaca tcatggagga cctggacaca      240

aaccaggaca atcagctgag ctttgaggag tgtatgatgc tgatggcaaa gttgatcttt      300

gcctgtcatg agaagctgca tgagaacaac ccacgtgggc atggccacag tcatggcaaa      360

ggctgtggga agtaattaag aggtcagcca tgtgactgct gcccaaccaa gtctaaaggg      420

aatggcttac tcaatggcct ttgttctggg aaatgataag ataaataata aataagtctt      480

tatccatt                                                               488


<210>  144
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  144

Ala Asn Lys Ala Pro Ser Gln Met Glu Arg Ser Ile Thr Thr Ile Ile 
1               5                   10                  15      


Asp Thr Phe His Gln Tyr Ser Arg Lys Glu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Ser Lys Lys Glu Phe Arg Gln Met Val Glu Ala Gln Leu Ala Thr Phe 
        35                  40                  45              


Met Lys Lys Glu Lys Arg Asn Glu Ala Leu Ile Asn Asp Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Gln Asp Asn Gln Leu Ser Phe Glu Glu Cys Met 
65                  70                  75                  80  


Met Leu Met Ala Lys Leu Ile Phe Ala Cys His Glu Lys Leu His Glu 
                85                  90                  95      


Asn Asn Pro Arg Gly His Gly His Ser His Gly Lys Gly Cys Gly Lys 
            100                 105                 110         


<210>  145
<211>  962
<212>  DNA
<213>  Mus musculus

<400>  145
gcaagcagat cctcagcgcc cagtcgccgc tctaagctcg catctccact cccctcccct       60

ccaccgagcc gtccacccgg cgccatgcat cccgcgcgcc ccgcgctctg ggcggctgcg      120

ctcactgccc tcactctgct ccgcggaccg ccggtggccg agctggccgc cggggcggtg      180

ggcgggcccg tggtgcgctg cgaaccgtgc gacgcgcgtg ccgtgtccca gtgcgcgcct      240

ccgcccaccg cgcccgcgtg cacggagctg gtgcgagagc ccggctgcgg ctgctgcctg      300

acttgcgcgc tgcgcgaagg cgacgcgtgc ggcgtctaca cggagcgctg tggcaccggc      360

ctccgctgcc agccgcggcc cgcggagcag tacccgctga gggcgctgct gaatggccgc      420

gggttctgcg ccaacgccag cgctgcaggc agcctaagca cctacctccc ctcccaacct      480

gctccaggaa acatcagtga gtccgaggag gagcacaatg ctgggagtgt ggaaagccag      540

gttgtcccca gcacacaccg agtgaccgat tccaagttcc atccactcca tgccaagatg      600

gatgtcatca aaaaaggcca cgccagggac agccagcgct acaaagttga ctatgagtct      660

caaagcacag acacccagaa cttctcctcc gagtctaagc gggagacaga atacggtccc      720

tgccgcagag aaatggagga cacactgaat catctgaagt tcctcaatgt gctgagtccc      780

agaggcgtcc acatcccaaa ctgtgacaag aaggggttct ataagaagaa acgatgccgc      840

ccttccaaag gcagaaagca gagcttctgc tggtgtgtgg acaagtatgg gcagcgcttg      900

ccaggctacg acaccaaggg gaaagacgac gtacattgcc tcagcgtgca gagccagtag      960

at                                                                     962


<210>  146
<211>  291
<212>  PRT
<213>  Mus musculus

<400>  146

Met His Pro Ala Arg Pro Ala Leu Trp Ala Ala Ala Leu Thr Ala Leu 
1               5                   10                  15      


Thr Leu Leu Arg Gly Pro Pro Val Ala Glu Leu Ala Ala Gly Ala Val 
            20                  25                  30          


Gly Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Val Ser 
        35                  40                  45              


Gln Cys Ala Pro Pro Pro Thr Ala Pro Ala Cys Thr Glu Leu Val Arg 
    50                  55                  60                  


Glu Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Arg Glu Gly Asp 
65                  70                  75                  80  


Ala Cys Gly Val Tyr Thr Glu Arg Cys Gly Thr Gly Leu Arg Cys Gln 
                85                  90                  95      


Pro Arg Pro Ala Glu Gln Tyr Pro Leu Arg Ala Leu Leu Asn Gly Arg 
            100                 105                 110         


Gly Phe Cys Ala Asn Ala Ser Ala Ala Gly Ser Leu Ser Thr Tyr Leu 
        115                 120                 125             


Pro Ser Gln Pro Ala Pro Gly Asn Ile Ser Glu Ser Glu Glu Glu His 
    130                 135                 140                 


Asn Ala Gly Ser Val Glu Ser Gln Val Val Pro Ser Thr His Arg Val 
145                 150                 155                 160 


Thr Asp Ser Lys Phe His Pro Leu His Ala Lys Met Asp Val Ile Lys 
                165                 170                 175     


Lys Gly His Ala Arg Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Arg Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Gln Ser Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Arg Leu 
            260                 265                 270         


Pro Gly Tyr Asp Thr Lys Gly Lys Asp Asp Val His Cys Leu Ser Val 
        275                 280                 285             


Gln Ser Gln 
    290     


<210>  147
<211>  884
<212>  DNA
<213>  Mus musculus

<400>  147
catgatccca gccacccgct cgcttctctg tgcagcgctg ctgctgctgg ccaccagccg       60

cctggccaca ggggcgccta tcgccaatga gctgcgctgt cagtgcctgc agaccatggc      120

tgggattcac ctcaagaaca tccagagctt gaaggtgttg ccctcagggc cccactgcac      180

ccaaaccgaa gtcatagcca cactcaagaa tggtcgcgag gcttgccttg accctgaagc      240

tcccttggtt cagaaaattg tccaaaagat gctaaaaggt gtccccaagt aacggagaaa      300

gaagacagac tgctctgatg gcaccgtctg gtgaacgctg gcttctgaca acactataca      360

atttcttttg agggtcctat ttatttatgt atttatttat tccacaaagt gtgtggtttt      420

tattttacat taatatttaa cagtgtggat acatttcatc gatggtagtt cagttctgct      480

tgttcagttt aaagatggta ggcttaaaat atttcattaa aactaatatt tattgggaga      540

ccactaagtg tcaaccactg tgctagtaga agggtgttgt gcgaaaagaa gtgcagagag      600

atagagttta gtattatgtt ttgtatgtat tagggtgagg acatgtgtgg gaggctgtgt      660

ttgtatgtct tgaaaagaat gtcagttatt tattgaaagt cgtctttcat attgtatggt      720

caacacgcac gtgttgacgc ttcccttgga cattttgtgt ctagttggta gcccataatg      780

ggcttttaca ttctttaacc ctgtttctcc tggtctcgtc tcgctcggga cagagacgtt      840

caaaggactg ttacaaatga agtaaaaata aaagttttat taag                       884


<210>  148
<211>  96
<212>  PRT
<213>  Mus musculus

<400>  148

Met Ile Pro Ala Thr Arg Ser Leu Leu Cys Ala Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Thr Ser Arg Leu Ala Thr Gly Ala Pro Ile Ala Asn Glu Leu Arg 
            20                  25                  30          


Cys Gln Cys Leu Gln Thr Met Ala Gly Ile His Leu Lys Asn Ile Gln 
        35                  40                  45              


Ser Leu Lys Val Leu Pro Ser Gly Pro His Cys Thr Gln Thr Glu Val 
    50                  55                  60                  


Ile Ala Thr Leu Lys Asn Gly Arg Glu Ala Cys Leu Asp Pro Glu Ala 
65                  70                  75                  80  


Pro Leu Val Gln Lys Ile Val Gln Lys Met Leu Lys Gly Val Pro Lys 
                85                  90                  95      


<210>  149
<211>  2334
<212>  DNA
<213>  Mus musculus

<400>  149
gctcttctct ccaagaagac tcagccagat ccactccagc tccgacccca ggagaccgac       60

ctcctccaga cggcagcagc cccagcccag ccgacaaccc cagacgccac cgcctggagc      120

gtccagacac caacctccgc ccctgtccga atccaggctc cagccgcgcc tctcgtcgcc      180

tctgcaccct gctgtgcatc ctcctaccgc gtcccgatca tgctcgcctc cgtcgcaggt      240

cccatcagcc tcgccttggt gctcctcgcc ctctgcaccc ggcctgctac gggccaggac      300

tgcagcgcgc aatgtcagtg cgcagccgaa gcagcgccgc actgccccgc cggcgtgagc      360

ctggtgctgg acggctgcgg ctgctgccgc gtctgcgcca agcagctggg agaactgtgt      420

acggagcgtg acccctgcga cccacacaag ggcctcttct gcgatttcgg ctcccccgcc      480

aaccgcaaga ttggagtgtg cactgccaaa gatggtgcac cctgtgtctt cggtgggtcg      540

gtgtaccgca gcggtgagtc cttccaaagc agctgcaaat accaatgcac ttgcctggat      600

ggggccgtgg gctgcgtgcc cctatgcagc atggacgtgc gcctgcccag ccctgactgc      660

cccttcccga gaagggtcaa gctgcctggg aaatgctgca aggagtgggt gtgtgacgag      720

cccaaggacc gcacagcagt tggccctgcc ctagctgcct accgactgga agacacattt      780

ggcccagacc caactatgat gcgagccaac tgcctggtcc agaccacaga gtggagcgcc      840

tgttctaaga cctgtggaat gggcatctcc acccgagtta ccaatgacaa taccttctgc      900

agactggaga agcagagccg cctctgcatg gtcaggccct gcgaagctga cctggaggaa      960

aacattaaga agggcaaaaa gtgcatccgg acacctaaaa tcgccaagcc tgtcaagttt     1020

gagctttctg gctgcaccag tgtgaagaca tacagggcta agttctgcgg ggtgtgcaca     1080

gacggccgct gctgcacacc gcacagaacc accactctgc cagtggagtt caaatgcccc     1140

gatggcgaga tcatgaaaaa gaatatgatg ttcatcaaga cctgtgcctg ccattacaac     1200

tgtcctgggg acaatgacat ctttgagtcc ctgtactaca ggaagatgta cggagacatg     1260

gcgtaaagcc aggaagtaag ggacacgaac tcattagact ataacttgaa ctgagttgca     1320

tctcattttc ttctgtaaaa acaattacag tagcacatta atttaaatct gtgtttttaa     1380

ctaccgtggg aggaactatc ccaccaaagt gagaacgtta tgtcatggcc atacaagtag     1440

tctgtcaacc tcagacactg gtttcgagac agtttacact tgacagttgt tcattagcgc     1500

acagtgccag aacgcacact gaggtgagtc tcctggaaca gtggagatgc caggagaaag     1560

aaagacaggt actagctgag gttattttaa aagcagcagt gtgcctactt tttggagtgt     1620

aaccggggag ggaaattata gcatgcttgc agacagacct gctctagcga gagctgagca     1680

tgtgtcctcc actagatgag gctgagtcca gctgttcttt aagaacagca gtttcagcct     1740

ctgaccattc tgattccagt gacacttgtc aggagtcaga gccttgtctg ttagactgga     1800

cagcttgtgg caagtaagtt tgcctgtaac aagccagatt tttattgata ttgtaaatat     1860

tgtggatata tatatatata tatatatttg tacagttatc taagttaatt taaagtcatt     1920

tgtttttgtt ttaagtgctt ttgggatttt aaactgatag cctcaaactc caaacaccat     1980

aggtaggaca cgaagcttat ctgtgattca aaacaaagga gatactgcag tgggaattgt     2040

gacctgagtg actctctgtc agaacaaaca aatgctgtgc aggtgataaa gctatgtatt     2100

ggaagtcaga tttctagtag gaaatgtggt caaatccctg ttggtgaaca aatggccttt     2160

attaagaaat ggctggctca gggtaaggtc cgattcctac caggaagtgc ttgctgcttc     2220

tttgattatg actggtttgg ggtggggggc agtttatttg ttgagagtgt gaccaaaagt     2280

tacatgtttg cacctttcta gttgaaaata aagtatatat atatttttta tatg           2334


<210>  150
<211>  348
<212>  PRT
<213>  Mus musculus

<400>  150

Met Leu Ala Ser Val Ala Gly Pro Ile Ser Leu Ala Leu Val Leu Leu 
1               5                   10                  15      


Ala Leu Cys Thr Arg Pro Ala Thr Gly Gln Asp Cys Ser Ala Gln Cys 
            20                  25                  30          


Gln Cys Ala Ala Glu Ala Ala Pro His Cys Pro Ala Gly Val Ser Leu 
        35                  40                  45              


Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu Gly 
    50                  55                  60                  


Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu Phe 
65                  70                  75                  80  


Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr Ala 
                85                  90                  95      


Lys Asp Gly Ala Pro Cys Val Phe Gly Gly Ser Val Tyr Arg Ser Gly 
            100                 105                 110         


Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp Gly 
        115                 120                 125             


Ala Val Gly Cys Val Pro Leu Cys Ser Met Asp Val Arg Leu Pro Ser 
    130                 135                 140                 


Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys Cys 
145                 150                 155                 160 


Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Arg Thr Ala Val Gly Pro 
                165                 170                 175     


Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro Thr 
            180                 185                 190         


Met Met Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala Cys 
        195                 200                 205             


Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp Asn 
    210                 215                 220                 


Thr Phe Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg Pro 
225                 230                 235                 240 


Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys Ile 
                245                 250                 255     


Arg Thr Pro Lys Ile Ala Lys Pro Val Lys Phe Glu Leu Ser Gly Cys 
            260                 265                 270         


Thr Ser Val Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr Asp 
        275                 280                 285             


Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu Phe 
    290                 295                 300                 


Lys Cys Pro Asp Gly Glu Ile Met Lys Lys Asn Met Met Phe Ile Lys 
305                 310                 315                 320 


Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe Glu 
                325                 330                 335     


Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345             


<210>  151
<211>  4921
<212>  DNA
<213>  Mus musculus

<400>  151
cttacgggtc atccaaaaac tgacttatga atctggcttc ctcaactatt ctaagtttga       60

agttgagtca aaagttgaat ctcagcacgt gggctccagc attctaacag ccaatggtcg      120

ggcactgctc aaggacgcaa aggcagaaat gactggtgag cacaatgcca acttaaatgg      180

aaaagttatt ggaactttga aaaattctct cttcttttca gcacaaccat ttgagattac      240

tgcatccaca aataatgaag gaaatttgaa agtgggtttt ccactaaagc tgactgggaa      300

aatagacttc ctgaataact atgcattgtt tctgagtccc cgtgcccaac aagcaagctg      360

gcaagcgagt accagattca atcagtacaa atacaatcaa aacttttctg ctataaacaa      420

tgaacacaac atagaagcca gtataggaat gaatggagat gccaacctgg atttcttaaa      480

cataccttta acaattcctg aaattaactt gccttacacg gagttcaaaa ctcccttact      540

gaaggatttc tccatatggg aagaaacagg cttgaaagaa tttttgaaga caacaaagca      600

atcatttgat ttgagtgtaa aggctcaata taaaaagaac agtgacaagc attccattgt      660

tgtccctctg ggtatgtttt atgaatttat tctcaacaat gtcaattcgt gggacagaaa      720

atttgagaaa gtcagaaaca atgctttaca ttttcttacc acctcctata atgaagcaaa      780

aattaaggtt gataagtaca aaactgaaaa ttcccttaat cagccctctg ggacctttca      840

aaatcatggc tacactatcc cagttgtcaa cattgaagta tctccatttg ctgtagagac      900

actggcttcc agccatgtga tccccacagc aataagcacc ccaagtgtca caatccctgg      960

tcctaacatc atggtgcctt catacaagtt agtgctgcca cccctggagt tgccagtttt     1020

ccatggtcct gggaatctat tcaagttttt cctcccagat ttcaagggat tcaacactat     1080

tgacaatatt tatattccag ccatgggcaa ctttacctat gacttttctt ttaaatcaag     1140

tgtcatcaca ctgaatacca atgctggact ttataaccaa tcagatatcg ttgcccattt     1200

cctttcttcc tcttcatttg tcactgacgc cctgcagtac aaattagagg gaacatcacg     1260

tctgatgcga aaaaggggat tgaaactagc cacagctgtc tctctaacta acaaatttgt     1320

aaagggcagt catgacagca ccattagttt aaccaagaaa aacatggaag catcagtgag     1380

aacaactgcc aacctccatg ctcccatatt ctcaatgaac ttcaagcagg aacttaatgg     1440

aaataccaag tcaaaaccca ctgtttcatc atccattgaa ctaaactatg acttcaattc     1500

ctcaaagctg cactctactg caacaggagg cattgatcac aagttcagct tagaaagtct     1560

cacttcctac ttttccattg agtcattcac caaaggaaat atcaagagtt ccttcctttc     1620

tcaggaatat tcaggaagtg ttgccaatga agccaatgta tatctgaatt ccaagggtac     1680

tcggtcttca gtgaggctac aaggagcttc caaagttgat ggtatctgga acgttgaagt     1740

aggagaaaat tttgctggag aagccaccct ccaacgcatc tacaccacat gggagcacaa     1800

tatgaaaaac catttgcagg tatatagcta cttcttcaca aaaggaaagc aaacatgcag     1860

agctactttg gagctctccc catggaccat gtcaaccttg ctacaggttc atgtgagtca     1920

actcagttcc ctccttgacc tccatcactt tgaccaggaa gtgatcctaa aagctaacac     1980

taagaaccag aagatcagct ggaaaggtgg ggtccaggtt gaatcacggg ttcttcagca     2040

caatgcacag ttctccaatg accaagaaga aatacggctt gaccttgcag gatccttaga     2100

cggacagctg tgggaccttg aagctatctt tttaccagta tatggcaaga gcttgcagga     2160

actcctacaa atggatggaa agcgacagta tcttcaagct tcaacttctc ttctatatac     2220

caaaaaccct aatggctatc tcctctcact ccccgtgcaa gaactggctg atagatttat     2280

tataccaggg ataaaactaa atgacttcag tggagtaaaa atctataaga agttaagtac     2340

ttcaccattt gccctcaacc taacaatgct ccccaaagta aaattccctg ggattgatct     2400

gttaacacag tactctacac cagagggctc ctctgtccct atttttgagg caactatacc     2460

tgaaattcat ttaactgtat cccagtttac acttccaaag agccttccag ttggcaacac     2520

agtctttgat ctgaataagt tggccaacat gattgccgat gttgacctgc ctagtgtcac     2580

cctgcctgag cagactattg taatcccacc cttggagttc tctgtacctg ctgggatttt     2640

tattcctttc tttggagaac tgactgcacg tgctgggatg gcttctcccc tgtataatgt     2700

cacttggagc gctggttgga aaaccaaagc agatcatgtt gaaacgttcc tagattccat     2760

gtgcacttca accttgcagt ttctggagta tgctttaaaa gttgtagaaa cacacaaaat     2820

tgaagaagat ctgttaacct ataatatcaa aggaacactt caacactgtg acttcaatgt     2880

ggagtataat gaagatggtc tatttaaagg actttgggac tggcagggag aggctcacct     2940

ggacatcacc agcccagcac tgactgactt tcatctgtac tacaaagaag acaagacaag     3000

tctgtctgcc tcagcagcct cctcgaccat cggcactgtg ggtctggatt cgagcacaga     3060

tgaccagagt gtggagctga atgtctactt ccacccacag tcccctccag agaagaaact     3120

cagcatattc aaaactgagt ggaggtacaa ggagtctgat ggtgaaaggt acatcaaaat     3180

taattgggaa gaagaggcag cttccagatt gctaggctcc ctaaaaagca atgtgcccaa     3240

ggcttctaag gctatttatg attatgccaa taagtaccac ctggaatacg tttcttcaga     3300

actaagaaaa agtctacagg tcaatgctga acatgccaga aggatggttg atgaaatgaa     3360

catgagtttc cagagagtag cccgtgatac ctaccagaat ctctatgagg agatgttggc     3420

tcagaagagc ctgagcatcc ctgagaatct caagaagagg gtgttagaca gtatagtaca     3480

tgttactcag aagtaccaca tggcagtcat gtggctgatg gactcattca ttcattttct     3540

gaaattcaat agagtccagt tcccagggta cgctggaaca tatactgtgg acgaactcta     3600

cactatagtc atgaaggaaa ccaagaagtc actgtctcag ctgtttaatg ggttaggaaa     3660

cctactttcc tacgttcaaa accaagtaga gaaatcaaga ttaatcaatg acataacatt     3720

taaatgtcct tttttctcaa aaccttgtaa actaaaagat ctcatattga ttttcaggga     3780

ggagttaaac attttatcaa acataggcca acaggatatc aagtttacaa caatactaag     3840

tagtcttcag ggctttttgg agagagtttt agacatcata gaagaacaaa ttaaatgcct     3900

aaaggacaat gaatctactt gtgttgctga ccatatcaac atggttttca aaatacaggt     3960

cccatatgct tttaaatccc taagagaaga catatacttt gtcctcggtg agttcaatga     4020

ctttcttcaa tccatacttc aggaggggtc ctacaagcta cagcaggtcc atcagtatat     4080

gaaggccctt cgtgaagagt attttgatcc gagcatggtt gggtggacag tgaaatatta     4140

tgaaatagaa gaaaatatgg ttgagctgat caagaccctt ttagtttcct ttagggatgt     4200

ctactctgaa tatagtgtga cagctgctga ttttgcttcc aaaatgtcaa ctcaagttga     4260

acaatttgtg tccagggata tcagagagta tcttagcatg cttactgata taaatggaaa     4320

gtggatggaa aagattgcag agctttctat tgtggcaaag gaaacaatga aaagctgggt     4380

cactgccgtg gccaaaataa tgtctgatta cccccagcag ttccactcca atctgcagga     4440

tttttcagac caactctcta gctactatga aaaatttgtt ggtgagtcca caagattgat     4500

tgacctgtcc attcaaaact accacgtgtt tctcagatac atcaccgagt tactgagaaa     4560

gctgcaggtg gccacagcca ataatgtgag cccctatata aagcttgctc aaggagagct     4620

gatgatcacc ttctgattca tctactaaca aattcaaatt aaaccttcac atagtaggag     4680

actttgtaga ctactataaa gaccatcctg agccagacct gcagtcaaca gcaagagcaa     4740

gaagcacata ggaactatac ctgcaaccaa gctggcataa gaaccaagac cttcaaagca     4800

gcctgaactc aagatgacat attttacaag ttagagtaaa gtcaagagct gagttgtttt     4860

gtccaactca ggatggaggg agggagggaa ggggaaataa ataaatactt ccttattgtg     4920

c                                                                     4921


<210>  152
<211>  1495
<212>  PRT
<213>  Mus musculus

<400>  152

Met Thr Gly Glu His Asn Ala Asn Leu Asn Gly Lys Val Ile Gly Thr 
1               5                   10                  15      


Leu Lys Asn Ser Leu Phe Phe Ser Ala Gln Pro Phe Glu Ile Thr Ala 
            20                  25                  30          


Ser Thr Asn Asn Glu Gly Asn Leu Lys Val Gly Phe Pro Leu Lys Leu 
        35                  40                  45              


Thr Gly Lys Ile Asp Phe Leu Asn Asn Tyr Ala Leu Phe Leu Ser Pro 
    50                  55                  60                  


Arg Ala Gln Gln Ala Ser Trp Gln Ala Ser Thr Arg Phe Asn Gln Tyr 
65                  70                  75                  80  


Lys Tyr Asn Gln Asn Phe Ser Ala Ile Asn Asn Glu His Asn Ile Glu 
                85                  90                  95      


Ala Ser Ile Gly Met Asn Gly Asp Ala Asn Leu Asp Phe Leu Asn Ile 
            100                 105                 110         


Pro Leu Thr Ile Pro Glu Ile Asn Leu Pro Tyr Thr Glu Phe Lys Thr 
        115                 120                 125             


Pro Leu Leu Lys Asp Phe Ser Ile Trp Glu Glu Thr Gly Leu Lys Glu 
    130                 135                 140                 


Phe Leu Lys Thr Thr Lys Gln Ser Phe Asp Leu Ser Val Lys Ala Gln 
145                 150                 155                 160 


Tyr Lys Lys Asn Ser Asp Lys His Ser Ile Val Val Pro Leu Gly Met 
                165                 170                 175     


Phe Tyr Glu Phe Ile Leu Asn Asn Val Asn Ser Trp Asp Arg Lys Phe 
            180                 185                 190         


Glu Lys Val Arg Asn Asn Ala Leu His Phe Leu Thr Thr Ser Tyr Asn 
        195                 200                 205             


Glu Ala Lys Ile Lys Val Asp Lys Tyr Lys Thr Glu Asn Ser Leu Asn 
    210                 215                 220                 


Gln Pro Ser Gly Thr Phe Gln Asn His Gly Tyr Thr Ile Pro Val Val 
225                 230                 235                 240 


Asn Ile Glu Val Ser Pro Phe Ala Val Glu Thr Leu Ala Ser Ser His 
                245                 250                 255     


Val Ile Pro Thr Ala Ile Ser Thr Pro Ser Val Thr Ile Pro Gly Pro 
            260                 265                 270         


Asn Ile Met Val Pro Ser Tyr Lys Leu Val Leu Pro Pro Leu Glu Leu 
        275                 280                 285             


Pro Val Phe His Gly Pro Gly Asn Leu Phe Lys Phe Phe Leu Pro Asp 
    290                 295                 300                 


Phe Lys Gly Phe Asn Thr Ile Asp Asn Ile Tyr Ile Pro Ala Met Gly 
305                 310                 315                 320 


Asn Phe Thr Tyr Asp Phe Ser Phe Lys Ser Ser Val Ile Thr Leu Asn 
                325                 330                 335     


Thr Asn Ala Gly Leu Tyr Asn Gln Ser Asp Ile Val Ala His Phe Leu 
            340                 345                 350         


Ser Ser Ser Ser Phe Val Thr Asp Ala Leu Gln Tyr Lys Leu Glu Gly 
        355                 360                 365             


Thr Ser Arg Leu Met Arg Lys Arg Gly Leu Lys Leu Ala Thr Ala Val 
    370                 375                 380                 


Ser Leu Thr Asn Lys Phe Val Lys Gly Ser His Asp Ser Thr Ile Ser 
385                 390                 395                 400 


Leu Thr Lys Lys Asn Met Glu Ala Ser Val Arg Thr Thr Ala Asn Leu 
                405                 410                 415     


His Ala Pro Ile Phe Ser Met Asn Phe Lys Gln Glu Leu Asn Gly Asn 
            420                 425                 430         


Thr Lys Ser Lys Pro Thr Val Ser Ser Ser Ile Glu Leu Asn Tyr Asp 
        435                 440                 445             


Phe Asn Ser Ser Lys Leu His Ser Thr Ala Thr Gly Gly Ile Asp His 
    450                 455                 460                 


Lys Phe Ser Leu Glu Ser Leu Thr Ser Tyr Phe Ser Ile Glu Ser Phe 
465                 470                 475                 480 


Thr Lys Gly Asn Ile Lys Ser Ser Phe Leu Ser Gln Glu Tyr Ser Gly 
                485                 490                 495     


Ser Val Ala Asn Glu Ala Asn Val Tyr Leu Asn Ser Lys Gly Thr Arg 
            500                 505                 510         


Ser Ser Val Arg Leu Gln Gly Ala Ser Lys Val Asp Gly Ile Trp Asn 
        515                 520                 525             


Val Glu Val Gly Glu Asn Phe Ala Gly Glu Ala Thr Leu Gln Arg Ile 
    530                 535                 540                 


Tyr Thr Thr Trp Glu His Asn Met Lys Asn His Leu Gln Val Tyr Ser 
545                 550                 555                 560 


Tyr Phe Phe Thr Lys Gly Lys Gln Thr Cys Arg Ala Thr Leu Glu Leu 
                565                 570                 575     


Ser Pro Trp Thr Met Ser Thr Leu Leu Gln Val His Val Ser Gln Leu 
            580                 585                 590         


Ser Ser Leu Leu Asp Leu His His Phe Asp Gln Glu Val Ile Leu Lys 
        595                 600                 605             


Ala Asn Thr Lys Asn Gln Lys Ile Ser Trp Lys Gly Gly Val Gln Val 
    610                 615                 620                 


Glu Ser Arg Val Leu Gln His Asn Ala Gln Phe Ser Asn Asp Gln Glu 
625                 630                 635                 640 


Glu Ile Arg Leu Asp Leu Ala Gly Ser Leu Asp Gly Gln Leu Trp Asp 
                645                 650                 655     


Leu Glu Ala Ile Phe Leu Pro Val Tyr Gly Lys Ser Leu Gln Glu Leu 
            660                 665                 670         


Leu Gln Met Asp Gly Lys Arg Gln Tyr Leu Gln Ala Ser Thr Ser Leu 
        675                 680                 685             


Leu Tyr Thr Lys Asn Pro Asn Gly Tyr Leu Leu Ser Leu Pro Val Gln 
    690                 695                 700                 


Glu Leu Ala Asp Arg Phe Ile Ile Pro Gly Ile Lys Leu Asn Asp Phe 
705                 710                 715                 720 


Ser Gly Val Lys Ile Tyr Lys Lys Leu Ser Thr Ser Pro Phe Ala Leu 
                725                 730                 735     


Asn Leu Thr Met Leu Pro Lys Val Lys Phe Pro Gly Ile Asp Leu Leu 
            740                 745                 750         


Thr Gln Tyr Ser Thr Pro Glu Gly Ser Ser Val Pro Ile Phe Glu Ala 
        755                 760                 765             


Thr Ile Pro Glu Ile His Leu Thr Val Ser Gln Phe Thr Leu Pro Lys 
    770                 775                 780                 


Ser Leu Pro Val Gly Asn Thr Val Phe Asp Leu Asn Lys Leu Ala Asn 
785                 790                 795                 800 


Met Ile Ala Asp Val Asp Leu Pro Ser Val Thr Leu Pro Glu Gln Thr 
                805                 810                 815     


Ile Val Ile Pro Pro Leu Glu Phe Ser Val Pro Ala Gly Ile Phe Ile 
            820                 825                 830         


Pro Phe Phe Gly Glu Leu Thr Ala Arg Ala Gly Met Ala Ser Pro Leu 
        835                 840                 845             


Tyr Asn Val Thr Trp Ser Ala Gly Trp Lys Thr Lys Ala Asp His Val 
    850                 855                 860                 


Glu Thr Phe Leu Asp Ser Met Cys Thr Ser Thr Leu Gln Phe Leu Glu 
865                 870                 875                 880 


Tyr Ala Leu Lys Val Val Glu Thr His Lys Ile Glu Glu Asp Leu Leu 
                885                 890                 895     


Thr Tyr Asn Ile Lys Gly Thr Leu Gln His Cys Asp Phe Asn Val Glu 
            900                 905                 910         


Tyr Asn Glu Asp Gly Leu Phe Lys Gly Leu Trp Asp Trp Gln Gly Glu 
        915                 920                 925             


Ala His Leu Asp Ile Thr Ser Pro Ala Leu Thr Asp Phe His Leu Tyr 
    930                 935                 940                 


Tyr Lys Glu Asp Lys Thr Ser Leu Ser Ala Ser Ala Ala Ser Ser Thr 
945                 950                 955                 960 


Ile Gly Thr Val Gly Leu Asp Ser Ser Thr Asp Asp Gln Ser Val Glu 
                965                 970                 975     


Leu Asn Val Tyr Phe His Pro Gln Ser Pro Pro Glu Lys Lys Leu Ser 
            980                 985                 990         


Ile Phe Lys Thr Glu Trp Arg Tyr  Lys Glu Ser Asp Gly  Glu Arg Tyr 
        995                 1000                 1005             


Ile Lys  Ile Asn Trp Glu Glu  Glu Ala Ala Ser Arg  Leu Leu Gly 
    1010                 1015                 1020             


Ser Leu  Lys Ser Asn Val Pro  Lys Ala Ser Lys Ala  Ile Tyr Asp 
    1025                 1030                 1035             


Tyr Ala  Asn Lys Tyr His Leu  Glu Tyr Val Ser Ser  Glu Leu Arg 
    1040                 1045                 1050             


Lys Ser  Leu Gln Val Asn Ala  Glu His Ala Arg Arg  Met Val Asp 
    1055                 1060                 1065             


Glu Met  Asn Met Ser Phe Gln  Arg Val Ala Arg Asp  Thr Tyr Gln 
    1070                 1075                 1080             


Asn Leu  Tyr Glu Glu Met Leu  Ala Gln Lys Ser Leu  Ser Ile Pro 
    1085                 1090                 1095             


Glu Asn  Leu Lys Lys Arg Val  Leu Asp Ser Ile Val  His Val Thr 
    1100                 1105                 1110             


Gln Lys  Tyr His Met Ala Val  Met Trp Leu Met Asp  Ser Phe Ile 
    1115                 1120                 1125             


His Phe  Leu Lys Phe Asn Arg  Val Gln Phe Pro Gly  Tyr Ala Gly 
    1130                 1135                 1140             


Thr Tyr  Thr Val Asp Glu Leu  Tyr Thr Ile Val Met  Lys Glu Thr 
    1145                 1150                 1155             


Lys Lys  Ser Leu Ser Gln Leu  Phe Asn Gly Leu Gly  Asn Leu Leu 
    1160                 1165                 1170             


Ser Tyr  Val Gln Asn Gln Val  Glu Lys Ser Arg Leu  Ile Asn Asp 
    1175                 1180                 1185             


Ile Thr  Phe Lys Cys Pro Phe  Phe Ser Lys Pro Cys  Lys Leu Lys 
    1190                 1195                 1200             


Asp Leu  Ile Leu Ile Phe Arg  Glu Glu Leu Asn Ile  Leu Ser Asn 
    1205                 1210                 1215             


Ile Gly  Gln Gln Asp Ile Lys  Phe Thr Thr Ile Leu  Ser Ser Leu 
    1220                 1225                 1230             


Gln Gly  Phe Leu Glu Arg Val  Leu Asp Ile Ile Glu  Glu Gln Ile 
    1235                 1240                 1245             


Lys Cys  Leu Lys Asp Asn Glu  Ser Thr Cys Val Ala  Asp His Ile 
    1250                 1255                 1260             


Asn Met  Val Phe Lys Ile Gln  Val Pro Tyr Ala Phe  Lys Ser Leu 
    1265                 1270                 1275             


Arg Glu  Asp Ile Tyr Phe Val  Leu Gly Glu Phe Asn  Asp Phe Leu 
    1280                 1285                 1290             


Gln Ser  Ile Leu Gln Glu Gly  Ser Tyr Lys Leu Gln  Gln Val His 
    1295                 1300                 1305             


Gln Tyr  Met Lys Ala Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Met 
    1310                 1315                 1320             


Val Gly  Trp Thr Val Lys Tyr  Tyr Glu Ile Glu Glu  Asn Met Val 
    1325                 1330                 1335             


Glu Leu  Ile Lys Thr Leu Leu  Val Ser Phe Arg Asp  Val Tyr Ser 
    1340                 1345                 1350             


Glu Tyr  Ser Val Thr Ala Ala  Asp Phe Ala Ser Lys  Met Ser Thr 
    1355                 1360                 1365             


Gln Val  Glu Gln Phe Val Ser  Arg Asp Ile Arg Glu  Tyr Leu Ser 
    1370                 1375                 1380             


Met Leu  Thr Asp Ile Asn Gly  Lys Trp Met Glu Lys  Ile Ala Glu 
    1385                 1390                 1395             


Leu Ser  Ile Val Ala Lys Glu  Thr Met Lys Ser Trp  Val Thr Ala 
    1400                 1405                 1410             


Val Ala  Lys Ile Met Ser Asp  Tyr Pro Gln Gln Phe  His Ser Asn 
    1415                 1420                 1425             


Leu Gln  Asp Phe Ser Asp Gln  Leu Ser Ser Tyr Tyr  Glu Lys Phe 
    1430                 1435                 1440             


Val Gly  Glu Ser Thr Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr 
    1445                 1450                 1455             


His Val  Phe Leu Arg Tyr Ile  Thr Glu Leu Leu Arg  Lys Leu Gln 
    1460                 1465                 1470             


Val Ala  Thr Ala Asn Asn Val  Ser Pro Tyr Ile Lys  Leu Ala Gln 
    1475                 1480                 1485             


Gly Glu  Leu Met Ile Thr Phe  
    1490                 1495 


<210>  153
<211>  2840
<212>  DNA
<213>  Mus musculus

<400>  153
ctggaccgcg gcgctgcatc ctcttaagta ctgagtgcga agttgctcag ggtgcggttg       60

tcgcggtcgc cgctgcctct cggtccaatg agctgcacca gaatgatcca tgtgctagat      120

ccacgtcctt tgacaagttc cgtcatgccc gtggacatgg ccatgaggat ttgcttggct      180

cattcaccac ctctgaagag tttcctgggt ccttacaatg gttttcaacg aagaaatttt      240

gtgaataaat tgaaaccttt gaaaccatgt ctcagtgtca agcaggaagc caaatcgcag      300

agtgagtgga agagcccaca caaccaagcc aagaagcggg tcgtgtttgc ggactccaag      360

gggctgtcac tcactgctat ccatgtcttc tccgaccttc cagaagaacc agcgtgggac      420

ctgcagtttg atctcttgga ccttaacgat atctcctcca gcttaaaact tcacgaggag      480

aaaaatttgg tttttgattt tccccagccc tcaaccgact acttaagttt ccgggaccgc      540

tttcagaaga actttgtctg cctcgagaac tgctctttgc aagatcggac ggtgaccggg      600

acagtgaaag tgaagaatgt gagctttgag aagaaggttc aggtccggat cacctttgac      660

acctggaaaa cctacacaga tgtggactgt gtctacatga agaatgttta cagcagctca      720

gacagcgaca ccttctcctt tgccatcgac ttgccccgtg tcattccaac tgaggagaaa      780

attgagttct gcatttctta tcacgctaat gggaggatct tctgggacaa caatgagggt      840

cagaattaca gaattgtcca tgtgcaatgg aaacctgacg gagtgcagac tcaggtggca      900

cccaaagact gtgcattcca acaggggccc cctaagactg agatagagcc cacagtcttt      960

ggcagtccaa ggcttgctag cggcctcttc ccagagtggc agagctgggg gagagtggag     1020

aacttgacct cctatcgatg agttaggcaa tctacacact gcccttgtct gatcataatc     1080

ctcatgcaat tctagatctg tattgctcaa tattaggaag tcgtagttac tttctatcag     1140

tagatttagg tatgagctgt tggggcctgg ctatagaagc tatagctact tgagaattca     1200

ttgttggggg tttttgaggg tgatgccacc agctttgttc tgaaggatca aggacagcct     1260

gggaactagt tttatacaag cgacaccttt ttttgggagg tgcatcattt ccctctcagt     1320

tcaccagctt tcactttgac caaggaaagg tttgaggact gttgatggtg atggaacgct     1380

gtggtaaggg tgtgaggaat gtgaaatgta tatgccgagg gctcgagtca gcggaggagc     1440

catggttaag tggatattaa gccattggtg ggaacacata aagttatctt gtgtttcaga     1500

atgggttctg caggcttctc ctgaggaaat agctcaaaga tgggaaagaa atccattcta     1560

tgcatccttg tataggaaaa taaaaggatg ttggatggta ctgggggaga agatgaactg     1620

aagaatcaag atcttgaggg ctagagatgt agctcagttg gtagtgtgct tgcctcgcat     1680

gcatgaagac ctgggttcca ggtctagcat catacagctg ggggtggcag cacatgcctc     1740

taatcccagt atgttatagg gaaggcagag gcaggaggat tagaaatcca aggtcatcct     1800

tggcacacag aaagttggag gctagcttgg gctagtcaag tccctgtctc aggaaatgat     1860

gatatcaaaa gatctcaagt gaatcctttc agtttaaaca tggtctacca ggaaccatgt     1920

tttagagagt gttgaagcac atctggcttt gcattcttaa ttggataagc ggctttgtga     1980

tgaaggcatc actcttgggt tcttgctaca gaatgctgcc tgacatcagg catgttgtca     2040

ccagtgacta gcagcatgta gggactccac atcgtgtcaa agagagctct ttcagtgcct     2100

ccattaaacc acaacactgt agctgtttaa accagttacc tgaatgctca tctaataact     2160

catgaatgtt taggacctta tttgaaggtc tattcactgg tgtccttctg aaatcatcag     2220

gagggccatc agtgtacaca actcacgtcc ttcatattga aggtgactca tctttctgcc     2280

acactttttc aatgtgacat ttgaagtggg gactgacacc agagtctcaa tgcaagaatc     2340

caggaccttg cacatgaaag tatcggtcta tctcgtgcct aattttgtct tgctgtttta     2400

atttctagtc aaaatgcttt taaaaagtgt agatatgaat tattttgaat gtgaactgtt     2460

tttgcgtgcg cataaatcca ctttgtggga tcttgaggac aggtgtcctg ggttgattgt     2520

ccggtgtgca tgtactttga ggtgagttgg gaaagtgcag tggattgtaa tgtatgtgat     2580

ctgccatgct ggaaaaacac tattgggata cctcccctgt gatggtattt gaggtttggc     2640

tagcatccat aagttctctg ctgtaaatac ctacattgtc cctatgagcc tctcactttt     2700

agaataaatg tgcttggtaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2760

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa                                                 2840


<210>  154
<211>  317
<212>  PRT
<213>  Mus musculus

<400>  154

Met Ser Cys Thr Arg Met Ile His Val Leu Asp Pro Arg Pro Leu Thr 
1               5                   10                  15      


Ser Ser Val Met Pro Val Asp Met Ala Met Arg Ile Cys Leu Ala His 
            20                  25                  30          


Ser Pro Pro Leu Lys Ser Phe Leu Gly Pro Tyr Asn Gly Phe Gln Arg 
        35                  40                  45              


Arg Asn Phe Val Asn Lys Leu Lys Pro Leu Lys Pro Cys Leu Ser Val 
    50                  55                  60                  


Lys Gln Glu Ala Lys Ser Gln Ser Glu Trp Lys Ser Pro His Asn Gln 
65                  70                  75                  80  


Ala Lys Lys Arg Val Val Phe Ala Asp Ser Lys Gly Leu Ser Leu Thr 
                85                  90                  95      


Ala Ile His Val Phe Ser Asp Leu Pro Glu Glu Pro Ala Trp Asp Leu 
            100                 105                 110         


Gln Phe Asp Leu Leu Asp Leu Asn Asp Ile Ser Ser Ser Leu Lys Leu 
        115                 120                 125             


His Glu Glu Lys Asn Leu Val Phe Asp Phe Pro Gln Pro Ser Thr Asp 
    130                 135                 140                 


Tyr Leu Ser Phe Arg Asp Arg Phe Gln Lys Asn Phe Val Cys Leu Glu 
145                 150                 155                 160 


Asn Cys Ser Leu Gln Asp Arg Thr Val Thr Gly Thr Val Lys Val Lys 
                165                 170                 175     


Asn Val Ser Phe Glu Lys Lys Val Gln Val Arg Ile Thr Phe Asp Thr 
            180                 185                 190         


Trp Lys Thr Tyr Thr Asp Val Asp Cys Val Tyr Met Lys Asn Val Tyr 
        195                 200                 205             


Ser Ser Ser Asp Ser Asp Thr Phe Ser Phe Ala Ile Asp Leu Pro Arg 
    210                 215                 220                 


Val Ile Pro Thr Glu Glu Lys Ile Glu Phe Cys Ile Ser Tyr His Ala 
225                 230                 235                 240 


Asn Gly Arg Ile Phe Trp Asp Asn Asn Glu Gly Gln Asn Tyr Arg Ile 
                245                 250                 255     


Val His Val Gln Trp Lys Pro Asp Gly Val Gln Thr Gln Val Ala Pro 
            260                 265                 270         


Lys Asp Cys Ala Phe Gln Gln Gly Pro Pro Lys Thr Glu Ile Glu Pro 
        275                 280                 285             


Thr Val Phe Gly Ser Pro Arg Leu Ala Ser Gly Leu Phe Pro Glu Trp 
    290                 295                 300                 


Gln Ser Trp Gly Arg Val Glu Asn Leu Thr Ser Tyr Arg 
305                 310                 315         


<210>  155
<211>  1901
<212>  DNA
<213>  Mus musculus

<400>  155
aacattggtt agaccaggac catggagccc agtgtcctgc tcctccttgc tctccttgtg       60

ggcttcttgt tactcttagc caggggacac ccaaagtccc gtggcaactt cccaccagga      120

ccccgtcccc tgcccctctt ggggaacctc ttgcagatgg acagaggagg cctcctcaag      180

tcttttattc agcttcgaga aaaatatgga gatgtgttca cagtgcacct gggaccaagg      240

cctgtggtta tgctgtgtgg aacagacacc ataagggagg ctctggtggg ccaagccgag      300

gctttctctg gccgggggac agttgctgtc gttgagccaa ccttcaagga atatggtgtg      360

atctttgcca atggggaacg ttggaagacc cttcgtagat tctctctggc caccatgaga      420

gactttggga tgggaaagag gagtgtggag gagcggattc aggaggaagc ccaatgttta      480

gtggaggaac tgcggaaatc ccagggagcc cccctggacc ccacgttcct cttccagtgc      540

atcacggcca atattatctg ctccattgtg tttggagagc gctttgagta cacagaccgt      600

cagttcttgc gcctgctgga gctgttctat cagacctttt cactcataag ctcattctcc      660

agccagatgt ttgagctctt ctctggcttc ctgaagtact ttcctggtgc ccacagacaa      720

atctccaaaa acctgcagga actcctcgac tacattggcc atagtgtgga gaagcacagg      780

gccaccttgg accccagtgt tccacgagac ttcattgata tttaccttct gcgcatggag      840

aaggagaagt ccaaccagca cacggagttc catcaccaga acctcatgat gtctgtgctc      900

tctctcttct ttgctggcac cgagaccagc agcaccacgc tccgctatgg cttcctgctc      960

atgctcaagt acccccatgt tgcagagaaa gtccaaaagg agattgatca ggtgatcggc     1020

tcacaccggc taccaaccct tgatgaccgc accaaaatgc catacactga tgcagtcatc     1080

cacgagattc agagattttc agatcttata cctattggag tgccacacag agtgaccaaa     1140

gataccatgt tccgagggta cctgctcccc aagaacactg aggtgtaccc catcctgagt     1200

tcagctctac atgatccaca gtactttgaa caaccagaca gtttcaatcc tgaccacttc     1260

ctggatgcca atggggcact gaagaaaagt gaagcttttc tgcccttctc aacaggaaag     1320

cgcatttgtc ttggtgaaag cattgcccgc aacgagttgt tccttttctt cacgtccatc     1380

ctccagaact tctctgtggc aagccatgtt gctcctaagg acattgacct cactcccaag     1440

gagagtggta ttggaaaaat acctccaacg taccagatct gcttcttggc ccgctgattg     1500

ggctgaggca gacaggtggc cccagtactg ttgagaatga ctctatcttt gagcctctga     1560

gagacctgct ggaaatcagt actcctattg catgtctcca aatctccagg gctccaaggc     1620

atgttcttct tccctgtgaa tggcactgga gaaatcaatc aactgtcttt cttgacatgt     1680

gaaaagagac ttctggagtc cacatctcat gttgagtcac ttcccttttc ctcccaatag     1740

cccaagtccg cacttatcag ctctccatga tctgggatct gtgctaatgg actctgtata     1800

aggtctgaat tctatgtcta cagatttgcc tagtatgtat ggttcaggta aacagaatca     1860

catagtgtga gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         1901


<210>  156
<211>  470
<212>  PRT
<213>  Mus musculus

<400>  156

Met Glu Pro Ser Val Leu Leu Leu Leu Ala Leu Leu Val Gly Phe Leu 
1               5                   10                  15      


Leu Leu Leu Ala Arg Gly His Pro Lys Ser Arg Gly Asn Phe Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Gly Gly Leu Leu Lys Ser Phe Ile Gln Leu Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Thr Asp Thr Ile Arg Glu Ala Leu Val Gly Gln Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Thr Val Ala Val Val Glu Pro Thr Phe Lys Glu Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Glu Arg Trp Lys Thr Leu Arg Arg Phe Ser 
        115                 120                 125             


Leu Ala Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Val Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Gln Gly Ala Pro Leu Asp Pro Thr Phe Leu Phe Gln Cys Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Glu Arg Phe Glu Tyr Thr Asp 
            180                 185                 190         


Arg Gln Phe Leu Arg Leu Leu Glu Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Phe Ser Ser Gln Met Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Ile Ser Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Leu Leu Asp Tyr Ile Gly His Ser Val Glu Lys His Arg Ala Thr Leu 
                245                 250                 255     


Asp Pro Ser Val Pro Arg Asp Phe Ile Asp Ile Tyr Leu Leu Arg Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Gln His Thr Glu Phe His His Gln Asn Leu 
        275                 280                 285             


Met Met Ser Val Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Ser Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Lys Val Gln Lys Glu Ile Asp Gln Val Ile Gly Ser His Arg 
                325                 330                 335     


Leu Pro Thr Leu Asp Asp Arg Thr Lys Met Pro Tyr Thr Asp Ala Val 
            340                 345                 350         


Ile His Glu Ile Gln Arg Phe Ser Asp Leu Ile Pro Ile Gly Val Pro 
        355                 360                 365             


His Arg Val Thr Lys Asp Thr Met Phe Arg Gly Tyr Leu Leu Pro Lys 
    370                 375                 380                 


Asn Thr Glu Val Tyr Pro Ile Leu Ser Ser Ala Leu His Asp Pro Gln 
385                 390                 395                 400 


Tyr Phe Glu Gln Pro Asp Ser Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Ser Glu Ala Phe Leu Pro Phe Ser Thr Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Ser Ile Ala Arg Pro Trp Met Lys Pro 
        435                 440                 445             


Met Lys Gly Ala Thr Pro Val Pro Gly Pro Thr Met Ile Thr Gly Val 
    450                 455                 460                 


Val Gly Pro Glu Phe Glu 
465                 470 


<210>  157
<211>  607
<212>  DNA
<213>  Mus musculus

<400>  157
atagaccacc agatctgccc aggagacacc agcaggatga agctactcac cagcctggtc       60

ttctgctccc tgctcctggg agtctgccat ggagggtttt tttcatttat tggggaggct      120

ttccaagggg ctggagacat gtggcgagcc tacactgaca tgaaggaagc tggctggaaa      180

gatggagaca aatacttcca tgctcggggg aactatgatg ctgcccaaag gggtcccggg      240

ggagtctggg ctgctgagaa aatcagtgat gcaagagaga gctttcagga attcttcggc      300

agaggacacg aggacaccat ggctgaccag gaagccaaca gacatggccg cagtggcaaa      360

gaccccaatt actacagacc tcctggactg cctgccaaat actgagagtc ctcctattag      420

ttcagaaggc tgtgttgggg tcctgagggt ggggtctggg cttcctatct aggaacactg      480

aagatgctct ctggggcaac atagtatacc tctcatgtgt gtatcccaca aggtttcaga      540

atggagttac tcgagcagta gtaactgctt gaggaggaga gggtaataaa caggaacttg      600

gaagtgg                                                                607


<210>  158
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  158

Met Lys Leu Leu Thr Ser Leu Val Phe Cys Ser Leu Leu Leu Gly Val 
1               5                   10                  15      


Cys His Gly Gly Phe Phe Ser Phe Ile Gly Glu Ala Phe Gln Gly Ala 
            20                  25                  30          


Gly Asp Met Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Gly Trp Lys 
        35                  40                  45              


Asp Gly Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Ser Phe Gln Glu Phe Phe Gly Arg Gly His Glu Asp Thr Met Ala 
                85                  90                  95      


Asp Gln Glu Ala Asn Arg His Gly Arg Ser Gly Lys Asp Pro Asn Tyr 
            100                 105                 110         


Tyr Arg Pro Pro Gly Leu Pro Ala Lys Tyr 
        115                 120         


<210>  159
<211>  637
<212>  DNA
<213>  Mus musculus

<400>  159
atagatcacc agatctgccc aggagacacc aggatgaagc tactcaccag cctggtcttc       60

tgctccctgc tcctgggagt ctgccatgga gggttttttt catttgttca cgaggctttc      120

caaggggctg gggacatgtg gcgagcctac actgacatga aggaagctaa ctggaaaaac      180

tcagacaaat acttccatgc tcgggggaac tatgatgctg ctcaaagggg tcccggggga      240

gtctgggctg ctgagaaaat cagtgatgga agagaggcct ttcaggaatt cttcggcaga      300

ggacatgagg acaccattgc tgaccaggaa gccaacagac atggccgcag tggcaaagac      360

cccaattact acagacctcc tggactgcct gacaaatact gagcgtcctc ctattagctc      420

agtaggttgt gctgggggcc tgagggtggg gtctgggctt cttcctacct aggaacactg      480

aagatgctct ctggggaaac attgtatatc tctcatgtgt gtatcccaca agggtttcag      540

aactgagtta ctcttgcagt agtaactgct tgaggaggag agggtaataa acagaaactt      600

ggaagcgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                               637


<210>  160
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  160

Met Lys Leu Leu Thr Ser Leu Val Phe Cys Ser Leu Leu Leu Gly Val 
1               5                   10                  15      


Cys His Gly Gly Phe Phe Ser Phe Val His Glu Ala Phe Gln Gly Ala 
            20                  25                  30          


Gly Asp Met Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Asn Trp Lys 
        35                  40                  45              


Asn Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Gly Arg 
65                  70                  75                  80  


Glu Ala Phe Gln Glu Phe Phe Gly Arg Gly His Glu Asp Thr Ile Ala 
                85                  90                  95      


Asp Gln Glu Ala Asn Arg His Gly Arg Ser Gly Lys Asp Pro Asn Tyr 
            100                 105                 110         


Tyr Arg Pro Pro Gly Leu Pro Asp Lys Tyr 
        115                 120         


<210>  161
<211>  1974
<212>  DNA
<213>  Mus musculus

<400>  161
ccacgcgtcc gcccacgcgt ccggtggagc tcagcctgct ggagcctagc catgacgctg       60

tggtgtacag tgctaggagc cctgctcacg gttgtgggat gcctgtgtct gtccttgctg      120

ctcaggcacc gcaggccctg ggagccacct ctggacaagg gttttgtgcc ctggctgggt      180

cactccatgg ctttccggaa gaatatgttt gaattcttga aggggatgcg ggccaagcac      240

ggggatgtct tcacggtgca gctgggaggc cagtacttca cctttgtcat ggaccccctg      300

tcctttggcc ccatcattaa gaacacagag aaagcgctgg acttccagtc ctatgcaaaa      360

gaactggtgc tcaaggtgtt tgggtaccag tctgtagatg gggaccacag gatgatccac      420

ttagctagta ccaagcatct gatggggcaa ggcttggagg aactcaacca ggccatgctg      480

gacagcctat ccttggtgat gctagggcct aaaggttcga gtctgggtgc cagctcctgg      540

tgtgaagatg gcctctttca cttctgctac agaatcctgt ttaaggctgg cttcctgagc      600

ttattcggct acaccaagga caagcagcaa gacctggatg aggccgatga gctgttcagg      660

aagttccgtc gatttgactt tctcttcccc aggtttgtct actccctact ggggccccgg      720

gagtgggtgg aagtgagcca gttgcagcgt ctcttccacc agagactctc tgtggagcaa      780

aacctggaaa aagacggcat aagctgttgg ttaggctaca tgcttcagtt tctgagggag      840

caaggaatag cttcatccat gcaggacaaa tttaacttta tgatgctctg ggcctcccag      900

gggaacacgg gacccacctg tttctgggtc ctcttattcc tgctgaagca ccaggatgcc      960

atgaaggctg tgcgtgagga agccaccagg gtcatgggta aggccaggct ggaagccaag     1020

aagtcgttca ctttcactcc cagtgccctg aaacacactc ccgtgttgga cagcgtgatg     1080

gaggagagtc tgcgtctctg tgccaccccc accctcctca gggtggtaca ggaggattat     1140

gtcctgaaga tggccagcgg gcaagagtac cagatccgtc gcggagataa ggtggctctc     1200

ttcccctatc tctcagtaca catggacccc gacatccacc ctgagcccac agccttcaag     1260

tatgatcggt tcctcaaccc ggatggcacc cggaaagtgg acttctacaa gtcgggcaag     1320

aagatccacc actacagcat gccttggggc tcgggtgttt ccaagtgccc cggcaggttc     1380

tttgccctca gcgagatgaa gacctttgtc cttcttatga ttatgtactt cgacttcaag     1440

ctggtcgacc ccgacatacc tgtgcccccc attgacccaa ggcgctgggg ctttggcacc     1500

tcacagccta gccatgaggt acgcttcctc tatcgcctga agcccgtgca gtgagctcag     1560

gtctgagcat accctgcagc ccagagcagc actgaatacc catcctctgg ctctgaggca     1620

ctccttcctc tccccagctc tcagagatct gtcatgctcc ccataagacg ccatccctcc     1680

agcggtctct gcctgaccct cctctcagga ggaacacatg tggtcagctc agtttacaac     1740

tgatggctca cccacacttg actcatcctg gagggcagac cagctcccgt gagtcagatg     1800

gcatcttgca aatgctgcct caacccatcc agcctgcctt actcgatgcc cttactccaa     1860

atcctaccag ctcagactcc agggatgttg ctcaatggaa tcgagccatg tgtgcgactg     1920

ttaatttccc actagatata aaagcaaggg attacgttga aaaaaaaaaa aaaa           1974


<210>  162
<211>  500
<212>  PRT
<213>  Mus musculus

<400>  162

Met Thr Leu Trp Cys Thr Val Leu Gly Ala Leu Leu Thr Val Val Gly 
1               5                   10                  15      


Cys Leu Cys Leu Ser Leu Leu Leu Arg His Arg Arg Pro Trp Glu Pro 
            20                  25                  30          


Pro Leu Asp Lys Gly Phe Val Pro Trp Leu Gly His Ser Met Ala Phe 
        35                  40                  45              


Arg Lys Asn Met Phe Glu Phe Leu Lys Gly Met Arg Ala Lys His Gly 
    50                  55                  60                  


Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val Met 
65                  70                  75                  80  


Asp Pro Leu Ser Phe Gly Pro Ile Ile Lys Asn Thr Glu Lys Ala Leu 
                85                  90                  95      


Asp Phe Gln Ser Tyr Ala Lys Glu Leu Val Leu Lys Val Phe Gly Tyr 
            100                 105                 110         


Gln Ser Val Asp Gly Asp His Arg Met Ile His Leu Ala Ser Thr Lys 
        115                 120                 125             


His Leu Met Gly Gln Gly Leu Glu Glu Leu Asn Gln Ala Met Leu Asp 
    130                 135                 140                 


Ser Leu Ser Leu Val Met Leu Gly Pro Lys Gly Ser Ser Leu Gly Ala 
145                 150                 155                 160 


Ser Ser Trp Cys Glu Asp Gly Leu Phe His Phe Cys Tyr Arg Ile Leu 
                165                 170                 175     


Phe Lys Ala Gly Phe Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys Gln 
            180                 185                 190         


Gln Asp Leu Asp Glu Ala Asp Glu Leu Phe Arg Lys Phe Arg Arg Phe 
        195                 200                 205             


Asp Phe Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Gly Pro Arg Glu 
    210                 215                 220                 


Trp Val Glu Val Ser Gln Leu Gln Arg Leu Phe His Gln Arg Leu Ser 
225                 230                 235                 240 


Val Glu Gln Asn Leu Glu Lys Asp Gly Ile Ser Cys Trp Leu Gly Tyr 
                245                 250                 255     


Met Leu Gln Phe Leu Arg Glu Gln Gly Ile Ala Ser Ser Met Gln Asp 
            260                 265                 270         


Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly Pro 
        275                 280                 285             


Thr Cys Phe Trp Val Leu Leu Phe Leu Leu Lys His Gln Asp Ala Met 
    290                 295                 300                 


Lys Ala Val Arg Glu Glu Ala Thr Arg Val Met Gly Lys Ala Arg Leu 
305                 310                 315                 320 


Glu Ala Lys Lys Ser Phe Thr Phe Thr Pro Ser Ala Leu Lys His Thr 
                325                 330                 335     


Pro Val Leu Asp Ser Val Met Glu Glu Ser Leu Arg Leu Cys Ala Thr 
            340                 345                 350         


Pro Thr Leu Leu Arg Val Val Gln Glu Asp Tyr Val Leu Lys Met Ala 
        355                 360                 365             


Ser Gly Gln Glu Tyr Gln Ile Arg Arg Gly Asp Lys Val Ala Leu Phe 
    370                 375                 380                 


Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro Thr 
385                 390                 395                 400 


Ala Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asp Gly Thr Arg Lys Val 
                405                 410                 415     


Asp Phe Tyr Lys Ser Gly Lys Lys Ile His His Tyr Ser Met Pro Trp 
            420                 425                 430         


Gly Ser Gly Val Ser Lys Cys Pro Gly Arg Phe Phe Ala Leu Ser Glu 
        435                 440                 445             


Met Lys Thr Phe Val Leu Leu Met Ile Met Tyr Phe Asp Phe Lys Leu 
    450                 455                 460                 


Val Asp Pro Asp Ile Pro Val Pro Pro Ile Asp Pro Arg Arg Trp Gly 
465                 470                 475                 480 


Phe Gly Thr Ser Gln Pro Ser His Glu Val Arg Phe Leu Tyr Arg Leu 
                485                 490                 495     


Lys Pro Val Gln 
            500 


<210>  163
<211>  6812
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (4837)..(4837)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4882)..(4882)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4886)..(4886)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4909)..(4909)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4929)..(4929)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4941)..(4941)
<223>  n is a, c, g, or t

<400>  163
cgacccggtg cgtgtgggcc agcggagcgc gggtagcagg ttgagggcaa ttctccatga       60

atgtacgtca ccatgatgat gaccgaccag atccccctgg aattgccacc tctgctcaat      120

ggggaggtgg ccatgatgcc ccacttggtg aacggagaag cagctcagca ggtcattctt      180

gtccaagtga acccaggtga gacctttacc atcagagccg aggatgggac acttcagtgc      240

atccaaggac ctgctgaagt tcccatgatg tcacccaatg ggtccattcc tcctatccat      300

gtgcctccag gttatatctc acaggtgatt gaagacagca ccggagtccg ccgggtggtg      360

gtcacaccgc agtctcctga gtgctaccca ccgagttatc cctcagccat gtctccaacc      420

catcacctgc ccccttatct gacccaccat ccacacttca tccagaactc gcacaccgcc      480

tactacccgc ccgtcaccgt gcctggagat atgccacccc agtttttccc ccagcctcac      540

cttcctccca caatatatag cgagccagaa attatccccc tgtatggaat gtcgagctac      600

gtcacccgag aagaccagta cagcaagcct ccacataaga agctgaagga ccgccagatc      660

gaccgccaga accgcctcaa cagcccacct tccaccatct acaagaacag ctgcgctaca      720

gtgtacaatg gctacgggaa aggccacagt ggagggagca gtggaggtgg gggaggtggc      780

agcggcggtg gacctgggat caagaagaca gagcgaagag cgaggagcag cccaaaatcc      840

agtgattctg acctgcaaga gtatgagttg gaagtaaaga gggtgcaaga cattctttcg      900

ggaatagaga aaccacaggt gtctaatatc caggcaagag cagttgtgct gtcttgggca      960

ccccctgtcg gactgtcctg tggaccccat ggtggtcttt ccttccctta cagctatgag     1020

gtcgccttat ctgacaaagg gcgagatggg aaatacaaga tcatttacag tggagaagag     1080

ttggagtgta acctgaaaga tctcaggcct gccacggatt accatgtgag ggtatatgcc     1140

gtgtacaatt ctgtcaaggg atcctgctcc gagccagtca gcttcaccac ccatagctgc     1200

gcaccagaat gtcccttccc tcccaagctg gcacacagga gcaaaagttc acttaccctg     1260

cagtggaagg ctccaattga caatggttca aaaatcacca gctacctttt agaatgggat     1320

gagggaaaga gaaacagtgg tttcagacag tgtttctttg gaagccagaa gcactgcaaa     1380

ctgacaaagc tctgtccagc catgggctac acgttcaggc tcgctgctcg gaacgacatc     1440

ggcaccagtg gttacagcca ggaggtcgtg tgctacacgt tgggaaacat cccgcagatg     1500

cccttggcac cccggcttgt ccgagccggc gtcacctgga tcaccctgca gtggagcagg     1560

ccagaaggct gctcgcctga ggaagtgata acctacaccc tggacattca ggaggatgag     1620

aacgatagcc atttccaccc aaaatacact ggagaggacc taacctgtac tgtgaaaaat     1680

ctcaagcgaa gcacacagta taaattcagg ctgactgctt ccaacatgga ggggaagagc     1740

tgcccaagtg aagtcctggt ttgtacaacc agccccgaca gacctggccc tccaaccaga     1800

cccctcatta aaggacctgt cacatcacat ggcttcagtg tcaagtggga tgctccaaag     1860

gacaacggtg gctcagaaat cctgaagtat ctgctggaga tcacggatgg aacttctgaa     1920

gctgggcagt gggaagtggc ctacagtgga tcggctacag agtatgtctt tacccatttg     1980

aaaccaggca ctttgtacaa actgcgagcg tgctgcatca gtaccggtgg gcacagtcag     2040

tgttctgaaa gtctccctgt ccgcacacta agccttgcac caggtcagtg ccgaccaccg     2100

agggttttgg gtagaccaaa gcacaaagga gtccacttag agtgggatgt gcctgcgtct     2160

gaaagtggct gtgaggtctc agaatacagt gtggaaatga cggaacccga gaatgtcgcc     2220

tcagaggtgt accatgggcc tgagctggag tgcacggttg gcaacctgct gcctggaact     2280

gtgtaccgct tcagagtgcg agctctgaat gacggagggt acggtcccta ctctgatgtg     2340

tcagaaatca ccactgccgc agggccccct gggcagtgca gagcaccgcg tgtctccttc     2400

acgcctgacg gatgcgtcct ggtgggctgg gagagccctg cgagccctgg tgccgacatc     2460

tccgaataca ggttggagtg gggagaagat gaacagtcct tagaactcgt ttatcatggt     2520

ccagacacct gctttgagat gcgagatctg ttgcctgctg cacagtattg ctgcagacta     2580

caggccttca atccagcagg cgcagggcca tatagtgagc ttgtccactg ccagacacca     2640

gcctctgccc ccgaccctgt ctccactctg tgtgtcctgg aggaggagcc ccccagtgcc     2700

cacccagact caccctctgt gtgccttgta ctgaactggg aagagccgtg caataatggg     2760

tctgaaatcc ttgcttataa catcgatctg ggagacagct gcattactgt gggcaacact     2820

accacacacg tgatgaagaa cctccttcca gaaacgacat accggatcag aattcaggct     2880

atcaatgaaa ttggagttgg accatttagt cagttcatta aagcaaaaac tcggccatta     2940

ccgccttcgc ctcctaggct tgagtgtgct gcgtctggtc ctcagagcct gaagctcaag     3000

tggggagaca gtaactccaa gacacatgct gctggtgaca tggtgtacac actacagctg     3060

gaagacagga acaagaggtt tatctcaatc taccgaggac ccagccacac ctacaaggtc     3120

cagagactga cagagtttac ctgctactcc ttcaggatcc aggcaatgag cgaggcaggg     3180

gaggggcctt actcagaaac ctacaccttc agcacaacca aaagcgtgcc tcccaccctc     3240

aaagcacctc gagtgacgca gttagaaggg aattcctgtg aaatcttctg ggagacggta     3300

ccaccgatga gaggcgaccc tgtgagctac gttctacagg tgctggttgg aagagactct     3360

gagtacaagc aggtgtacaa gggagaagaa gccacattcc aaatctcagg cctccagagc     3420

aacacagatt acaggttccg cgtgtgtgcc tgccgccgct gtgtggacac gtctcaggag     3480

ctcagtggcg cgttcagccc ctctgcggct ttcatgttac aacagcgtga ggttatgctt     3540

acaggggacc tgggaggcat ggaagaggcc aagatgaagg gcatgatgcc caccgacgaa     3600

cagtttgctg cactcatcgt gcttgctgtc gcgaccctgt ccattttgtt tgcctttata     3660

ttacagtact tcttaatgaa gtaaatccag caggccagtg gtatgctcgg aacgccacac     3720

gttttaatac acatttactc agagcctccc ctttttacgc tgtttcgttc tttgatttat     3780

acgcttctct tgttttacac atttagctag gggaaagagt ttggctgcac ctatttgaga     3840

tgcaaaacta ggaagaggtt aaactggatt tttttttaaa caataataaa taaaggaata     3900

aagaagagaa ggaagcggcg ggcaagctcc agacaccgag agccagtgtg cccaacgagc     3960

ttgccttgtc gggcttcccc gtgtgcttct ggtctgttcc cactgatgtc tttcgcaagc     4020

ctttgatcat cttgtgtgtt acagttcagt aatttatatt cacagtcatt tcttgatcat     4080

ctatacctgt taacagaatc acagtgtatg tagttcatgg ctgggattcc ggtgttgtca     4140

gagtattgcc acatgagaat attcagtgtg ccttcggagg aggccacctc gaccatcctt     4200

acgtcactca gttacgtaac tgtgttagct catctaagtc aaagtgtgta ctttaatcta     4260

aaatgtttta ttactctgta tcccttatga ttttaacact atgagttgcc tgtctaagaa     4320

gtcacataac caaatgcgcc tataaatgat agagcattgt agattttcac atcggtccat     4380

agcagtaact ttaagagggc attgtgcaat agttagttgt ttcttgttcg gctactttaa     4440

aagctgcttt aacttgtctg tctgtctttg tacataacta cttctaatat aatcactaga     4500

gttattatat tctgttatgt ttgaccggaa ttatgtgacg agagctcatg gcagttgtga     4560

actgtctcct tacatgttgg cccatcatat ttgaaagact tgcctttggt attctttggg     4620

gtgtcagtga cgtgaatgaa gttgaatacc atatttcagt gcccatgata ctaatgtagc     4680

agtagataga aatcttactg ataaagccca ccacaaggga ccatttacat ttgtcctgtt     4740

tctgggggct tcatctggcc gcatggagag agggagtgga aactggctgt gagcatgaga     4800

tgttttgggg ccaagagcct actagattct ctccctnggt ctgtcaataa tttgctttgt     4860

gacctctctg tgcctgtttc cnatgnatga gtaatcaaat caaatgggna ttcaaaacct     4920

gaaagtgcna agagcccttg natccaccgg tgctatgtaa gtgcggagaa tcactctcac     4980

ggattcactt agagtcatga ggtaatgagt tctaacccaa agtcattgga tccctcaacc     5040

aagtccacaa tgttcaagta cctcagggac acttaagagt tggaggtgca actgtattcc     5100

aaaagggtgc gacagacaca gccgattccc ctcttcctgt ttttttgtat atttttgctc     5160

cttggttttt cttgatcata gctactttgt gcttggtcta tgttgtctat gatgcagtaa     5220

gtaccctgta ctagcttata ctattcccat accaaagtca tggggaaacc aacattattt     5280

tgttttgggt ttatttatac tctattctgc atacagtact ttaaatgcca atgacagtgc     5340

aatctttatt tattgtaatg ttaaatgtac ttattactaa tgtgccctcc tagcatgtta     5400

tattttgtgt gttttatact ttttgtaatt ttaggtcagt ttagttcctt ggcaacatct     5460

gtagtattag ccttctgaca tctttcttgt gtttttaaag ataagagcat ctaactcatt     5520

aaatgcccaa aaaaaaaaaa aaatccatta ccagtgattg aaaggtttac atgtacccag     5580

aaaccatatt catctcctgg aagagtgcta agatcaatgc attgtcgcgt gcctatattg     5640

atagagttat gcactagaga gttctgtatt ttgttatcga ctatggtgat tagtgtaatt     5700

agacgtgtac actgatggta tcaaggtaaa tctatttttg ccaaagctct ggccttcgga     5760

agctcatcct tccatcgaag tgtgtctttt ggcccactgt gacgtcactt ctgcattccc     5820

tgcggcagtc acaggcgggt gaaggcagat gcagtggaat ggtttttaag gctattcatt     5880

cacagggaga gtcttttttt aaaaaaaaaa caaaacactt cagcactgct gctgtaaaga     5940

attccctgaa ttgttgaatt gttacaaagg aaattatact tcaggccaaa aacccctttg     6000

atcttgcaga gattccgata ctcggtaact ctcagaatgc tgaagcgtgt gacacacgag     6060

ccgacagcac tttattctct cgctcgccat tatttgctat tcattatagt ctcttcagtc     6120

aggaagttat tcctctacat ggcactattc tctatcacat atctgtatat gtgctatgga     6180

tatataacta tatatattgc catttcaaag gaacaataaa accaagtgtt ctgttgacct     6240

tgtctgtgcc ctttgccata cgtaggaatg agtgagtggc tttccgatgt tctgatgcgt     6300

ctctgtgtgt cacatgcatc cctgacacag gaaattccag gcatctgaag caaactgccc     6360

tttgtcctca aagaaaatgt ttaaaaagaa aactttttaa aaggctattt tgcatattat     6420

ctgccttgtt cttatcacac ttgagatgtt gacattttct gaccctgtgt ctttggctac     6480

aatcattcag tatttgtgtc aaatttgaca agtgccctaa tagaatgtgt ttgaatgtta     6540

tccttgcaca attctttaaa ttgaaagaca aaatgtttta cctcactgtt ggacatacat     6600

tccaggcttt tcgactttag gagaaaaaaa aaattaatca tatgttttcc tgtcttgtaa     6660

attttagatt atttcatata cattgtatta aaactgccat atcaatttta atgtatagat     6720

tttgcaaata ctatgctata tgtaatacct aactgtatct gtagtgtata tgtaatatat     6780

ttatgcccaa taaatgtttt aattctttct ga                                   6812


<210>  164
<211>  357
<212>  PRT
<213>  Mus musculus

<400>  164

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Glu Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile Gln Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Val Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln Pro His 
145                 150                 155                 160 


Leu Pro Pro Thr Ile Tyr Ser Glu Pro Glu Ile Ile Pro Leu Tyr Gly 
                165                 170                 175     


Met Ser Ser Tyr Val Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Thr Ile Tyr Lys Asn Ser Cys Ala Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser 
                245                 250                 255     


Ser Pro Lys Ser Ser Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val 
            260                 265                 270         


Lys Arg Val Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser 
        275                 280                 285             


Asn Ile Gln Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly 
    290                 295                 300                 


Leu Ser Cys Gly Pro His Gly Gly Leu Ser Phe Pro Tyr Ser Tyr Glu 
305                 310                 315                 320 


Val Ala Leu Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr 
                325                 330                 335     


Ser Gly Glu Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr 
            340                 345                 350         


Asp Tyr His Val Arg 
        355         


<210>  165
<211>  1629
<212>  DNA
<213>  Mus musculus

<400>  165
cagaactggt gcttctgtgg acttggccat ttgcacagca caagcagtga tggataactc       60

ctctgtctgt cccccaaatg caactgtctg cgaaggcgat tcctgcgtag tacctgagag      120

caacttcaat gcaattctca atacagtgat gagcactgtg ctcaccatcc tcttagccat      180

ggtgatgttt tctatggggt gcaatgtgga agtccacaag ttcctaggac atataaagag      240

accatggggt atcttcgtgg gcttcctctg tcagtttgga atcatgcctc tcacaggctt      300

tatcctgtct gtggcctctg gcatccttcc tgtacaggct gtagtggtgc taattatggg      360

ttgctgccct ggaggaactg gctccaatat cctggcctat tggatagatg gcgacatgga      420

cctcagtgtt agcatgacca cttgctccac actgcttgcc cttggaatga tgcctctttg      480

cctcttcgtc tacaccaaga tgtgggttga ctcgggaacg attgtgattc cctatgatag      540

cattggtatt tctctggttg ctcttgttat tcctgtttcc tttggaatgt ttgtaaatca      600

caaatggcca caaaaagcga agattatact taaaattgga tccatcacag gtgtaattct      660

cattgtgctc atagctgtga ttggaggaat actgtaccaa agtgcctgga tcattgaacc      720

caaactgtgg attataggaa caatattccc tatagctggc tacagcctgg gtttcttcct      780

ggctagacta gctggtcaac cctggtacag gtgccgaaca gtagccttgg aaactggaat      840

gcagaacact cagctgtgct ccaccattgt acagctctcc ttctcccccg aggatctcaa      900

cctggtgttc accttcccac tcatctatac tgttttccag ctcgtctttg cagcagtaat      960

attaggaatt tatgtcacat acaggaaatg ttatggaaaa aatgatgctg agtttctaga     1020

gaaaacagac aatgaaatgg actccaggcc atcatttgat gagacaaaca agggatttca     1080

accagatgag aagtagacaa gaaagaaaaa gaaaacttca gaacaatatt cattaaacta     1140

aaactgaatt tatttctttt ggtggaaaat catcagaaaa aacaaattta aaagttaaat     1200

tcaaattgaa attatgtttt ttgtataaag taatccattc tttagtgtga caaagatcca     1260

aagatatatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtacatgag     1320

cgtacgatcg tacatgagtc agttttctgt attcatagtc agattggtca caagatattc     1380

cttgatttca aattcacaga agcttaagcc tcttttttta aaaaggcagt gtttatatta     1440

atctcttatt acttcagatc aatattatct tactaaaata tttaacatga tgtaaatgtg     1500

taaatagttg tttcactgta ttgtttagga aatgatgttt tttaaagtct atgatatttt     1560

atgttcagta caggtatcat ttttcagata tttttggcca tagtgagtta aaatcataga     1620

tgtcaaact                                                             1629


<210>  166
<211>  2012
<212>  DNA
<213>  Mus musculus

<400>  166
aaattgatta tcattaatat attatcagaa aatatctata gacctaattt gatataggtc       60

aaattggaaa cttggtcata tgtaagctga actcagagtt aagcattttt gtttgttaaa      120

atataacata ttattactgt aaaataatta ttttcttcag tgtttatgat tgtaaaatga      180

ttgatgtgaa tgaatgtatt cctctgacat tttaatcatg agtttgaaga tttgcaacat      240

atttatttgt ggttttgcac tatactccga caaatatctg tatttgtatt ttagaaaagt      300

aggtccttca aatgatattc cagaaataga aacaagagaa agtattgcta atcaactgaa      360

gaacaaacta gaattgaatt aactcatcaa catattttat atccattcat atgcctctag      420

ggtccctgat gcccttttta tctttcaaga aatagagatc attcaataca gtttgaattt      480

gacaattaat ttttggaact ctgaagaggt ttgttcaaat atgatctgta tgaagcaggt      540

ctaaatggga caatatgata gatattaagc ccatatgaag tgccatacca gtcaccatga      600

gcaggaggta tcagaagtta caaaggaaca atggtatcag tctagaaaat gacataatac      660

aatgaagaga taaataaatg taaggaaaag cacagataaa agaaatattg aaaaaactta      720

atatggcaaa tctgatgtgt gacaggaagt agctacagga agattcatgt cagaaagtga      780

gatttgaaga agataagaag tccccaggca acaaagtagg aaaatcattt ctcagatgtc      840

atagatatag atatatacct gtctatatct gaaatggtag aaaccaaata agacttataa      900

atcagcaaga ctgtatggct gtcataggga tggaatttgt gcttgtcttt ttccttgaga      960

cccaacttga tttacttttc ttcattttgg aggagaaaca tgtttttaac tagtctttgg     1020

ttgttggtct tatggcaact tttgatattg ccaaaggctt gtggattcct ttaatttata     1080

atgtttttgc tccaaagact attctgcatt tgaatgatct gactttagat cacaatgagg     1140

gcttctggtt gtagacttaa aatattttgg ctggagatat tgtcacagtc tgtacagtgt     1200

ttgctctgac agcatgaggg tctgaactag actaccaaca ctcatataaa aatgccaggt     1260

atgatactgt gcagctgtaa tcccagtact agaaagaaga aaccaggagg ataagagcca     1320

gtctagccaa tcagtgagct ctgagttcag tgaaagacca tgttgcaaaa actaaaataa     1380

agagctacaa aggaagacac ttgccattga ccacatgtac atcacacaga cacacacaca     1440

cacacacaca cacacacaca catttggagc atttttccat cactagacaa aagcagaaag     1500

ttgaactcag aatgtcttaa ggcattggac atttattggt agataggaga ctggattttc     1560

ttcttgataa tgtcaagaaa gtacgtccaa acatggaaaa tgaagtctag ttcttaagta     1620

cctcttaaca ttcctcatca agaagaaaac tgacagatgc attaaagaca ccatgtgaat     1680

ttcgatcaag ttttcaacac cccccaaatt aagggcctgg atgccagcag ctgaatcaac     1740

tgggttttca tccctaatga ttaaagaata tgagtgacat agaacttcat tttcttacca     1800

tatatggtgg cttgtgaggt tatttttccc cctaatattc tagaagaata gaagaatatt     1860

ctagaaaaag agttaagcat tctaaaatta caaatctctt tttttaatga ttttgaaaag     1920

ctgatgaaat catatatatt attgcctctg tttcatatta aatgaatatt tttattttaa     1980

aggcataaat aaaaaaatga ttgtgtacta tc                                   2012


<210>  167
<211>  348
<212>  PRT
<213>  Mus musculus

<400>  167

Met Asp Asn Ser Ser Val Cys Pro Pro Asn Ala Thr Val Cys Glu Gly 
1               5                   10                  15      


Asp Ser Cys Val Val Pro Glu Ser Asn Phe Asn Ala Ile Leu Asn Thr 
            20                  25                  30          


Val Met Ser Thr Val Leu Thr Ile Leu Leu Ala Met Val Met Phe Ser 
        35                  40                  45              


Met Gly Cys Asn Val Glu Val His Lys Phe Leu Gly His Ile Lys Arg 
    50                  55                  60                  


Pro Trp Gly Ile Phe Val Gly Phe Leu Cys Gln Phe Gly Ile Met Pro 
65                  70                  75                  80  


Leu Thr Gly Phe Ile Leu Ser Val Ala Ser Gly Ile Leu Pro Val Gln 
                85                  90                  95      


Ala Val Val Val Leu Ile Met Gly Cys Cys Pro Gly Gly Thr Gly Ser 
            100                 105                 110         


Asn Ile Leu Ala Tyr Trp Ile Asp Gly Asp Met Asp Leu Ser Val Ser 
        115                 120                 125             


Met Thr Thr Cys Ser Thr Leu Leu Ala Leu Gly Met Met Pro Leu Cys 
    130                 135                 140                 


Leu Phe Val Tyr Thr Lys Met Trp Val Asp Ser Gly Thr Ile Val Ile 
145                 150                 155                 160 


Pro Tyr Asp Ser Ile Gly Ile Ser Leu Val Ala Leu Val Ile Pro Val 
                165                 170                 175     


Ser Phe Gly Met Phe Val Asn His Lys Trp Pro Gln Lys Ala Lys Ile 
            180                 185                 190         


Ile Leu Lys Ile Gly Ser Ile Thr Gly Val Ile Leu Ile Val Leu Ile 
        195                 200                 205             


Ala Val Ile Gly Gly Ile Leu Tyr Gln Ser Ala Trp Ile Ile Glu Pro 
    210                 215                 220                 


Lys Leu Trp Ile Ile Gly Thr Ile Phe Pro Ile Ala Gly Tyr Ser Leu 
225                 230                 235                 240 


Gly Phe Phe Leu Ala Arg Leu Ala Gly Gln Pro Trp Tyr Arg Cys Arg 
                245                 250                 255     


Thr Val Ala Leu Glu Thr Gly Met Gln Asn Thr Gln Leu Cys Ser Thr 
            260                 265                 270         


Ile Val Gln Leu Ser Phe Ser Pro Glu Asp Leu Asn Leu Val Phe Thr 
        275                 280                 285             


Phe Pro Leu Ile Tyr Thr Val Phe Gln Leu Val Phe Ala Ala Val Ile 
    290                 295                 300                 


Leu Gly Ile Tyr Val Thr Tyr Arg Lys Cys Tyr Gly Lys Asn Asp Ala 
305                 310                 315                 320 


Glu Phe Leu Glu Lys Thr Asp Asn Glu Met Asp Ser Arg Pro Ser Phe 
                325                 330                 335     


Asp Glu Thr Asn Lys Gly Phe Gln Pro Asp Glu Lys 
            340                 345             


<210>  168
<211>  386
<212>  DNA
<213>  Mus musculus

<400>  168
gatcacgctc ctagaactct tcaaaccgat ctctcgtcga tcttcaaccg ccgcctccac       60

tcgccatgga ccccaactgc tcctgtgcct ccgatggatc ctgctcctgc gctggcgcct      120

gcaaatgcaa acaatgcaaa tgtacttcct gcaagaaaag ctgctgctcc tgctgccccg      180

tgggctgtgc gaagtgctcc cagggctgca tctgcaaaga ggcttccgac aagtgcagct      240

gctgtgcctg aaggggggcg gaggggtccc cacatctgtg taaatagacc atgtagaagc      300

ctagcctttt ttgtacaacc ctgactcgtt ctccacaact ttttctataa agcatgtaac      360

tgacaataaa agccgttgac ttgatt                                           386


<210>  169
<211>  61
<212>  PRT
<213>  Mus musculus

<400>  169

Met Asp Pro Asn Cys Ser Cys Ala Ser Asp Gly Ser Cys Ser Cys Ala 
1               5                   10                  15      


Gly Ala Cys Lys Cys Lys Gln Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ser Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Glu Ala Ser Asp Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210>  170
<211>  1633
<212>  DNA
<213>  Mus musculus

<400>  170
cagccactga atctcaaggt ccttacaatg aaatgcagct gggtcatctt cttcctgatg       60

gcagtggtta taggggtcaa ttcagaggtt cagctgctgc agtctgggac agagcttgtg      120

aggccagggg cctcagtcaa gttgtcctgc acagcttctg gcttcagcat taaagacagc      180

cttctacact gggtgatgca gaggcctgaa cagggcctgg agtggattgg atggattgat      240

cctgaggatg gtgagactaa atatgtcccg aagttccagg acaaggccac tttaactgca      300

gccacatcct ccaacacagc ctacctgcag ctcagcagcc tgacatctgg ggacactgcc      360

acctattact gtctcttcta tggctacgac gacgggcggg actactttga ctactggggc      420

caaggcacca ctatcacagt ctcctcagcc aaaacaacac ccccatcagt ctatccactg      480

gcccctgggt gtggagatac aactggttcc tctgtgactc tgggatgcct ggtcaagggc      540

tacttccctg agtcagtgac tgtgacttgg aactctggat ccctgtccag cagtgtgcac      600

accttcccag ctctcctgca gtctggactc tacactatga gcagctcagt gactgtcccc      660

tccagcacct ggccaagtca gaccgtcacc tgcagcgttg ctcacccagc cagcagcacc      720

acggtggaca aaaaacttga gcccagcggg cccatttcaa caatcaaccc ctgtcctcca      780

tgcaaggagt gtcacaaatg cccagctcct aacctcgagg gtggaccatc cgtcttcatc      840

ttccctccaa atatcaagga tgtactcatg atctccctga cacccaaggt cacgtgtgtg      900

gtggtggatg tgagcgagga tgacccagac gtccagatca gctggtttgt gaacaacgtg      960

gaagtacaca cagctcagac acaaacccat agagaggatt acaacagtac tatccgggtg     1020

gtcagtgccc tccccatcca gcaccaggac tggatgagtg gcaaggagtt caaatgcaag     1080

gtcaacaaca aagacctccc atcacccatc gagagaacca tctcaaaaat taaagggcta     1140

gtcagagctc cacaagtata catcttgccg ccaccagcag agcagttgtc cagggaagat     1200

gtcagtctca cttgcctggt cgtgggcttc aaccctggag acatcagtgt ggagtggacc     1260

agcaatgggc atacagagga gaactacaag gacaccgcac cagtcctgga ctctgacggt     1320

tcttacttca tatacagcaa gctcgatata aaaacaagca agtgggagaa aacagattcc     1380

ttctcatgca acgtgagaca cgagggtctg aaaaattact acctgaagaa gaccatctcc     1440

cggtctccgg gtaaatgagc tcagcaccca caaagctctc aggtcctaag agacactggc     1500

acccatatcc atgcatccct tgtataaata aagcatccag caaagcctgg taccatgtaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaa                                                        1633


<210>  171
<211>  336
<212>  PRT
<213>  Mus musculus

<400>  171

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val 
65                  70                  75                  80  


Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys 
                85                  90                  95      


Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys 
            100                 105                 110         


Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu 
    130                 135                 140                 


Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
145                 150                 155                 160 


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
                165                 170                 175     


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val 
            180                 185                 190         


Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
        195                 200                 205             


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr 
    210                 215                 220                 


Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu 
225                 230                 235                 240 


Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys 
                245                 250                 255     


Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser 
            260                 265                 270         


Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp 
        275                 280                 285             


Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser 
    290                 295                 300                 


Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly 
305                 310                 315                 320 


Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys 
                325                 330                 335     


<210>  172
<211>  1928
<212>  DNA
<213>  Mus musculus

<400>  172
caagcggcct ccaaccggtc ttgtcactgc gctgcctctg ctccaccttc tctggccctg       60

gccgctagtg ctcagagtgc ctgcagtccg cctgtagcat gtgtggcatc tgggccctct      120

tcggcagcga tgactgcctt tccgtgcagt gtctgagtgc gatgaagatc gcgcacaggg      180

ggccagatgc atttcgcttt gagaatgtca atggatacac caactgctgc tttggctttc      240

accgcttggc tgtggttgac ccgctgtttg gaatgcagcc gataagagtg aggaaatacc      300

cttatttgtg gctctgttac aatggtgaaa tctacaacca caaggcgcta cagcaacgtt      360

ttgaatttga atatcagacc aatgtggatg gtgagattat cctccacctc tatgacaaag      420

gaggcatcga gaaaaccatc tgtatgctgg acggggtgtt tgcattcatc ttactggaca      480

ctgccaataa gaaagtattt ctgggcagag acacctatgg agtcaggccc ttgtttaaag      540

ccatgacaga agatgggttt ctggctgtgt gttcagaagc taaaggcctt gtttccttaa      600

aacactccac cactcccttc ttaaaagtgg agcccttcct tcctggacac tatgaagttt      660

tggatttaaa accaaatggc aaagttgcgt ctgtggaaat ggtcaaatac catcactgta      720

cggatgaacc attgcatgcc atctatgaca gcgtggagaa actcttccca ggctttgacc      780

tagagaccgt gaagaacaat ctgcgtatcc tttttgacaa cgctatcaag aaacgcttga      840

tgacagaccg gaggattggc tgccttttat cagggggcct ggactcgagc ttggttgctg      900

cctctctgct gaagcaactc aaggaggccc aagttcagta tcctctccag acatttgcta      960

ttggcatgga ggacagcccc gatctcctgg ccgctagaaa ggtggcaaat tatattggaa     1020

gcgagcatca tgaagtcctt tttaactctg aagaaggcat tcaggccctg gatgaagtca     1080

tattttcctt ggaaacttat gatattacga cagttcgggc atctgtgggc atgtatttaa     1140

tttccaagta tattcggaag aacacagaca gcgtggtgat cttctccgga gaggggtcag     1200

atgaacttac acagggctat atatatttcc acaaggctcc ttcccctgag aaggccgagg     1260

aggagagtga gagactgctg aaggaactct acctgtttga tgttctccgg gccgaccgca     1320

ctactgccgc acatggtctc gaactgagag tcccctttct ggatcatcgg ttttcttcct     1380

attacctgtc tctgccgcca gatatgagaa ttccaaaaaa tggcatagaa aaacatctcc     1440

tgagagagac ttttgaggac tgcaacctgc tacccaaaga gattctctgg cgacccaaag     1500

aagccttcag tgatgggatc acctcagtca agaactcctg gttcaagatt ttgcaggact     1560

atgttgaaca tcaggttgat gatgaaatga tgtctgcagc ctcccagaag tttcccttca     1620

atactcccaa aactaaggaa ggctacttct accgtcagat ctttgaacgc cattacccag     1680

gccgggctga ttggctgact cattattgga tgcctaagtg gatcaatgct actgaccctt     1740

ctgcccgcac tctgacccat tataagtcag ctgccaaagc ttaggcactc tctacactct     1800

tgtgtaaaag taaatgtttc ttccggctct gaaggtcgag acagcgacac aatcagaaag     1860

aatgagactc agccatcagt cacccaggct tacttaggca tgaaaagaaa taaaagtttc     1920

acatctga                                                              1928


<210>  173
<211>  560
<212>  PRT
<213>  Mus musculus

<400>  173

Cys Gly Ile Trp Ala Leu Phe Gly Ser Asp Asp Cys Leu Ser Val Gln 
1               5                   10                  15      


Cys Leu Ser Ala Met Lys Ile Ala His Arg Gly Pro Asp Ala Phe Arg 
            20                  25                  30          


Phe Glu Asn Val Asn Gly Tyr Thr Asn Cys Cys Phe Gly Phe His Arg 
        35                  40                  45              


Leu Ala Val Val Asp Pro Leu Phe Gly Met Gln Pro Ile Arg Val Arg 
    50                  55                  60                  


Lys Tyr Pro Tyr Leu Trp Leu Cys Tyr Asn Gly Glu Ile Tyr Asn His 
65                  70                  75                  80  


Lys Ala Leu Gln Gln Arg Phe Glu Phe Glu Tyr Gln Thr Asn Val Asp 
                85                  90                  95      


Gly Glu Ile Ile Leu His Leu Tyr Asp Lys Gly Gly Ile Glu Lys Thr 
            100                 105                 110         


Ile Cys Met Leu Asp Gly Val Phe Ala Phe Ile Leu Leu Asp Thr Ala 
        115                 120                 125             


Asn Lys Lys Val Phe Leu Gly Arg Asp Thr Tyr Gly Val Arg Pro Leu 
    130                 135                 140                 


Phe Lys Ala Met Thr Glu Asp Gly Phe Leu Ala Val Cys Ser Glu Ala 
145                 150                 155                 160 


Lys Gly Leu Val Ser Leu Lys His Ser Thr Thr Pro Phe Leu Lys Val 
                165                 170                 175     


Glu Pro Phe Leu Pro Gly His Tyr Glu Val Leu Asp Leu Lys Pro Asn 
            180                 185                 190         


Gly Lys Val Ala Ser Val Glu Met Val Lys Tyr His His Cys Thr Asp 
        195                 200                 205             


Glu Pro Leu His Ala Ile Tyr Asp Ser Val Glu Lys Leu Phe Pro Gly 
    210                 215                 220                 


Phe Asp Leu Glu Thr Val Lys Asn Asn Leu Arg Ile Leu Phe Asp Asn 
225                 230                 235                 240 


Ala Ile Lys Lys Arg Leu Met Thr Asp Arg Arg Ile Gly Cys Leu Leu 
                245                 250                 255     


Ser Gly Gly Leu Asp Ser Ser Leu Val Ala Ala Ser Leu Leu Lys Gln 
            260                 265                 270         


Leu Lys Glu Ala Gln Val Gln Tyr Pro Leu Gln Thr Phe Ala Ile Gly 
        275                 280                 285             


Met Glu Asp Ser Pro Asp Leu Leu Ala Ala Arg Lys Val Ala Asn Tyr 
    290                 295                 300                 


Ile Gly Ser Glu His His Glu Val Leu Phe Asn Ser Glu Glu Gly Ile 
305                 310                 315                 320 


Gln Ala Leu Asp Glu Val Ile Phe Ser Leu Glu Thr Tyr Asp Ile Thr 
                325                 330                 335     


Thr Val Arg Ala Ser Val Gly Met Tyr Leu Ile Ser Lys Tyr Ile Arg 
            340                 345                 350         


Lys Asn Thr Asp Ser Val Val Ile Phe Ser Gly Glu Gly Ser Asp Glu 
        355                 360                 365             


Leu Thr Gln Gly Tyr Ile Tyr Phe His Lys Ala Pro Ser Pro Glu Lys 
    370                 375                 380                 


Ala Glu Glu Glu Ser Glu Arg Leu Leu Lys Glu Leu Tyr Leu Phe Asp 
385                 390                 395                 400 


Val Leu Arg Ala Asp Arg Thr Thr Ala Ala His Gly Leu Glu Leu Arg 
                405                 410                 415     


Val Pro Phe Leu Asp His Arg Phe Ser Ser Tyr Tyr Leu Ser Leu Pro 
            420                 425                 430         


Pro Asp Met Arg Ile Pro Lys Asn Gly Ile Glu Lys His Leu Leu Arg 
        435                 440                 445             


Glu Thr Phe Glu Asp Cys Asn Leu Leu Pro Lys Glu Ile Leu Trp Arg 
    450                 455                 460                 


Pro Lys Glu Ala Phe Ser Asp Gly Ile Thr Ser Val Lys Asn Ser Trp 
465                 470                 475                 480 


Phe Lys Ile Leu Gln Asp Tyr Val Glu His Gln Val Asp Asp Glu Met 
                485                 490                 495     


Met Ser Ala Ala Ser Gln Lys Phe Pro Phe Asn Thr Pro Lys Thr Lys 
            500                 505                 510         


Glu Gly Tyr Phe Tyr Arg Gln Ile Phe Glu Arg His Tyr Pro Gly Arg 
        515                 520                 525             


Ala Asp Trp Leu Thr His Tyr Trp Met Pro Lys Trp Ile Asn Ala Thr 
    530                 535                 540                 


Asp Pro Ser Ala Arg Thr Leu Thr His Tyr Lys Ser Ala Ala Lys Ala 
545                 550                 555                 560 


<210>  174
<211>  1918
<212>  DNA
<213>  Mus musculus

<400>  174
agatgtagat gtctgtgcca cgtgccatga acatgccaca tgccagcaaa aggaagggaa       60

gagaatctgc atttgcaact atgggttttg gggcaacggg aggacacggt gtgttgacaa      120

agatgagtgc cagtttggag ccactgtgat ctgtgggaac cacacatcct gccacaacac      180

gcctggaggg ttctactgca tttgccacga gggctaccgg gccacaaata acaacgagac      240

gttcatcccc aatgacggca ctttctgtgc agacatcgat gagtgtgaag attctggcct      300

gtgcagacat ggagggcggt gtgtcaatac tcctgggagc tttgcatgct actgcatgga      360

agggtatgtg gcaaagaacg ggcctgagcc tttccaccca cgcacggatg ccacatcgtg      420

cacagaaata gactgtggca tccctcctga agttccagag atcagctgtg gcagccctcc      480

tgaaattcag aacgccatct tggtcgggaa tcacagctcc agacagggga gtgtggctca      540

ttatgactgt caggagggct ttgagagtcc aggaggaaag atcacttccg tttgcacaga      600

gaaaggcgcc tggagtgaaa tcacttatgc atgcacagaa ataatgatag aaattcatga      660

tgtgttggtg tttaatgaca cctgtgtgag atggcaaata agtccagaga gagtgaacgc      720

caggatcgtg tacctgcgga atcagtttat gaggagacag tcaatgtgac cacagacagc      780

agaaccccag aagtgtgcct gcacctccaa caaggaacca attacaccat aagcatttct      840

gcagcccctc ccaggcgctc tgtgcccgcc atccttggct tccagacccc tgaagatgat      900

ctcttagaag atgacggact tttcaatatc tcagtattta atgaaacttg tttgacgttg      960

agcaggcact ctaggcaagt tggatcagaa caaatgtacc aagttctggg tcagaggtgg     1020

tatctagaga gctcctacca tgctgctctc tttaacttca caacaagaga ccgagctcca     1080

gaagtgtgtt tagatctgta ccccgctact gattacacga taaacatcac ccttctgaga     1140

cccactgagc cgcgctccgc acaaataacc ataacaacca gcaaaacaga ccatcgctaa     1200

tatttcggta tataatgata cctgcctgag atggagcagc ctcaagacag ctgatgtact     1260

agagatgtat ttttccacat ttggggccag agatggtatc agaaggcatt tgtccaggaa     1320

atggtcttca atacaaccag cagcagccag gaccctgaga tatgcctgga cctgcatcaa     1380

ggcaccagct acaacgttag ccttcaggct ctgtcttcgg cacttcccgt ggtcatctac     1440

ctgacaaccc agatcacagg cagttcatat caggtgttgg tccttcccct gtccttgcaa     1500

agcacatttt cttgtgattc tgaaggcatg acttcattct ttggcaacac ttctcctgct     1560

gacggatatg tggctgcaga aatcctggcc agtgatgttc cagacgacac gttggagata     1620

tctattggag acaggctcta ctatggggaa tattacaatg cacctttgaa aacaggaaat     1680

gagtactgca ttctgttacg gatcacaagt gaatggaata aggtgagaag atattcctgt     1740

gctgtctggg ctgaggtaaa agactcatcg ctcacagcgc agcagatggt gggtgttgga     1800

ctgggctccg tggcttttgt gaccatcctt gcattcttct ccttctcagc agtgtgtgtt     1860

ctgacagctt ctcagggaga tgggcttaag tctgggcaaa tgtttcaagc attttagg       1918


<210>  175
<211>  169
<212>  PRT
<213>  Mus musculus

<400>  175

Met Ala Asn Lys Ser Arg Glu Ser Glu Arg Gln Asp Arg Val Pro Ala 
1               5                   10                  15      


Glu Ser Val Tyr Glu Glu Thr Val Asn Val Thr Thr Asp Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Cys Leu His Leu Gln Gln Gly Thr Asn Tyr Thr Ile Ser 
        35                  40                  45              


Ile Ser Ala Ala Pro Pro Arg Arg Ser Val Pro Ala Ile Leu Gly Phe 
    50                  55                  60                  


Gln Thr Pro Glu Asp Asp Leu Leu Glu Asp Asp Gly Leu Phe Asn Ile 
65                  70                  75                  80  


Ser Val Phe Asn Glu Thr Cys Leu Thr Leu Ser Arg His Ser Arg Gln 
                85                  90                  95      


Val Gly Ser Glu Gln Met Tyr Gln Val Leu Gly Gln Arg Trp Tyr Leu 
            100                 105                 110         


Glu Ser Ser Tyr His Ala Ala Leu Phe Asn Phe Thr Thr Arg Asp Arg 
        115                 120                 125             


Ala Pro Glu Val Cys Leu Asp Leu Tyr Pro Ala Thr Asp Tyr Thr Ile 
    130                 135                 140                 


Asn Ile Thr Leu Leu Arg Pro Thr Glu Pro Arg Ser Ala Gln Ile Thr 
145                 150                 155                 160 


Ile Thr Thr Ser Lys Thr Asp His Arg 
                165                 


<210>  176
<211>  2475
<212>  DNA
<213>  Mus musculus

<400>  176
ggcgtggacg cgcgcaggcc tggcggcggc gggacaagct ggggtctcag aatggagcac       60

agttctgcgt ctgtccctgc tgcactgccg tactatgtgg ccttctccca gctgctgggc      120

ctcactgtag tggctgtgac tggtgcgtgg ctgggtctgt accgaggtgg cattgcctgg      180

gaaagctccc tgcagtttaa tgtgcacccg ctctgcatgg tcataggcat gatcttcctt      240

caaggagatg ctctgctggt gtaccgtgtc ttcagaagag aagccaaacg cacgaccaag      300

atcttgcatg ggctgctgca cgtcttcgcc ttcatcatcg ccctggtggg gttggtggct      360

gtgttcgact accacaagaa gaagggctat gcagacctgt acagcttgca cagctggtgt      420

gggatcttag tctttgttct gtactttgtg cagtggctcg tgggtttcag cttcttcctg      480

ttccctggag cttcattctc tctgcggagc cgctaccgcc ctcagcacat tttctttggt      540

gccaccatct tcctcttctc tgtgggcaca gccctactgg gcctgaagga ggccctgctg      600

tttaaattgg ggtccaagta cagcacgttt gaacctgagg gggtgctggc caacgtgcta      660

ggcttgctgc tggtctgttt tggggtggtt gtgctctaca tcttggctca ggctgactgg      720

aagcggcctt cccaggctga agagcaagcc ctctccatgg acttcaagac actcacggag      780

ggagacagcc ccagtcccca gtgatcgccc tccttgtcct cttggctctg tgggtttcca      840

gatatctttt tgctcttccc tgcagacact gagtctctta ggtccaggag tgtgagtgtg      900

gggctgtgtt gttagttgag tggggttcca ggctttggag ttgttctcag tctcccttcc      960

tccccttcct ctctgcagct tttgatacat cctgtgagcc ctgagtaggc tctgtctgcc     1020

tgtacccgct gttgtccgtt cacgtgcaga aagcttggtt aggggatctg gggtcaagcc     1080

tggccctgat ccctattgga gctagacaat agctccgccc tccatgcagc agatggctgc     1140

tgggcctggg cctgagggac tggcatggag aagtcagacc gctgctttgt gtattcaacc     1200

caggagttcc agcagcttgg gaagcatgtg tccttggcag tagagcaagt gatattatgt     1260

gtaaaatatg ctggtgttca gaggaaggct ccccagaaag gttgactctg gctcccaaag     1320

gagccttggc gtgtgggttg gctacagtct ttaggccttt ctgttctttt aaaatccctg     1380

atcattaaat aggcttttcg tggggaaggg gattagtgat caaaactcag gtaaatacct     1440

gccctggtgg aggagggcag gctgcttgct cacagtgagg gctgccctgg cagagtacct     1500

cccttcagca ggggctaagc cctagcttcc ttctgcgggc cagcctgggc agactctgag     1560

agtgggaggc cacacctccg gagtttttgg aagagggctg ctgtttgcct tgttctccag     1620

gggggctgct ggggtaccct ggcttggggt gccctgtctt ggttgaagca gccctgaggg     1680

atcatggtcc tcccagccct gggtccatca tcgctggaca gtaggactga agtggaagag     1740

aggaacggga ttggtctcct gcacttagct tcaaccccct actgcctgtt gcgttgttag     1800

ctgagtcact gtttggcttg agtctagaga tattgggatt agagcactga tcttgtattc     1860

tctggcttgg cacatgctct cttcttgttt tccttctctc gggttttaag cctcacagtt     1920

tgtgacacac atggttaact tagtgaggaa atgaatggtt tctgaacctg gcagttcttt     1980

aagtcactag gctggttttc tctgtcagat ttctaataac tgcgtgggcc ctgcttctgg     2040

tgaggtctct tcccccagct gtggtgtagc tctctccctg atgctccctc accttccctc     2100

ccgtctctcc acttgctagg atggtgaggt ttgcctccag ttccaactgt atatgctgta     2160

aggctaggga atcttaggag ttctgtcgtc ggttggcaca cttgtacagt caagtgttta     2220

catctgggcg actcggcctt agacaaactc acgagtacca tttcgagtct cccttgccag     2280

actacacaga gaattagaag ttaggtctgc aatgagagtc tgtaaactag tctttttgcc     2340

aaagtgtatg atacatgact aaggaccaaa gaaagccccc aagcagatgt ctgtggtttc     2400

ttctgtctct tctgtctcct gtgacgtaca gtgtgttgtt ggtgcaacag aggaatcaat     2460

aaatgtctac agccg                                                      2475


<210>  177
<211>  250
<212>  PRT
<213>  Mus musculus

<400>  177

Met Glu His Ser Ser Ala Ser Val Pro Ala Ala Leu Pro Tyr Tyr Val 
1               5                   10                  15      


Ala Phe Ser Gln Leu Leu Gly Leu Thr Val Val Ala Val Thr Gly Ala 
            20                  25                  30          


Trp Leu Gly Leu Tyr Arg Gly Gly Ile Ala Trp Glu Ser Ser Leu Gln 
        35                  40                  45              


Phe Asn Val His Pro Leu Cys Met Val Ile Gly Met Ile Phe Leu Gln 
    50                  55                  60                  


Gly Asp Ala Leu Leu Val Tyr Arg Val Phe Arg Arg Glu Ala Lys Arg 
65                  70                  75                  80  


Thr Thr Lys Ile Leu His Gly Leu Leu His Val Phe Ala Phe Ile Ile 
                85                  90                  95      


Ala Leu Val Gly Leu Val Ala Val Phe Asp Tyr His Lys Lys Lys Gly 
            100                 105                 110         


Tyr Ala Asp Leu Tyr Ser Leu His Ser Trp Cys Gly Ile Leu Val Phe 
        115                 120                 125             


Val Leu Tyr Phe Val Gln Trp Leu Val Gly Phe Ser Phe Phe Leu Phe 
    130                 135                 140                 


Pro Gly Ala Ser Phe Ser Leu Arg Ser Arg Tyr Arg Pro Gln His Ile 
145                 150                 155                 160 


Phe Phe Gly Ala Thr Ile Phe Leu Phe Ser Val Gly Thr Ala Leu Leu 
                165                 170                 175     


Gly Leu Lys Glu Ala Leu Leu Phe Lys Leu Gly Ser Lys Tyr Ser Thr 
            180                 185                 190         


Phe Glu Pro Glu Gly Val Leu Ala Asn Val Leu Gly Leu Leu Leu Val 
        195                 200                 205             


Cys Phe Gly Val Val Val Leu Tyr Ile Leu Ala Gln Ala Asp Trp Lys 
    210                 215                 220                 


Arg Pro Ser Gln Ala Glu Glu Gln Ala Leu Ser Met Asp Phe Lys Thr 
225                 230                 235                 240 


Leu Thr Glu Gly Asp Ser Pro Ser Pro Gln 
                245                 250 


<210>  178
<211>  2805
<212>  DNA
<213>  Mus musculus

<400>  178
accgatatat acagggtttg gaggtgttct cttaggcaac tgtgcatttc ctcagatgga       60

tcttcaatgg tttctccact ggacatctgt tttttagtat gatttgagag tgtctatagc      120

aaggtggaga ggaggttttt ctctgcaata taaggcacaa tggaaggtcc tcgctcagac      180

gtgggccgct ggggcaggag cccctggcag ccccctacaa caccgtcacc ggagccagag      240

ccggagccgg agccagacag acgctcgcgc tcccgccgag gaggaggccg ctccttctgg      300

gctcgttgtt gtggctgctg ctcatgtggg aacagagggg acgatgactg gggacctgaa      360

ccttctggct ccagaagcag agggaccagc tcccggggta gggactctcg gggtggccga      420

agacccgagt ctcggggcag tggtgtaaat gcagctggag atggcaccat ccgagaggga      480

atgctggttg tgactggtgt ggatctgctg tgctcacgat cagaccagaa ccgccgagag      540

caccacacgg atgagtttga atatgatgag ctgattgtgc gccgtgggca gcccttccac      600

atgatccttt tcttgaaccg ggaatatgag tcctctgatc gcattgccct tgagctcctc      660

attggaagca atccggaggt gggcaagggc acccacgtga tcatcccagt gggtaaggga      720

ggcagtggtg gctggaaggc ccaagtgact aagaacaacg gacacaacct aaacctacgc      780

gtccacacct cccccaatgc catcattggc aagtttcagt tcactgtccg cacccgctct      840

gaagctggag agttccagtt gccctttgac ccccgcaatg agatctacat cctcttcaat      900

ccctggtgcc cagaggacat agtgtatgtg gaccatgagg actggcggca agaatatgtg      960

cttaatgagt ctggaagaat ctactatgga acagaagcac agattggcga acgaacctgg     1020

aactatggtc agtttgacca tggggtgctg gatgcctgcc tgtacatcct ggatcggagg     1080

gggatgccat atggaggtcg tggggaccca gtcagtgtct ctcgggttgt ctctgccatg     1140

gtgaactccc tggatgacaa tggagttctg attgggaact ggaccggtga ctactctcga     1200

ggcaccaacc cctcagcgtg ggtgggcagt gtggagatcc tgctcagcta cctacgcacc     1260

ggctattccg tcccctacgg ccaatgctgg gtctttgccg gtgtgaccac cacagtgctc     1320

cgatgtctgg gcttcgctac ccgtaccgtc accaacttca actctgcaca cgacacagac     1380

acctccctca ctatggacat ctactttgat gagaacatga agccacttga acatctgaac     1440

catgattctg tttggaactt ccacgtgtgg aacgactgct ggatgaagag gccagatctg     1500

ccctcaggct ttgatgggtg gcaggttgtg gatgccacac cccaggagac cagcagtggc     1560

atcttctgct gtggcccctg ttctgtggag tccgtcaaga acggcttagt ctacatgaag     1620

tatgacacac ctttcatttt tgctgaggta aatagcgata aggtatactg gcagcggcag     1680

gatgatggca gctttaagat agtgtacgtg gaagagaaag ccattggcac actcattgtc     1740

acaaaggcga tccactccaa caatcgagag gacatcaccc acatctataa gcacccagaa     1800

ggctcagaag cagagcggag ggctgtggag aaggcggcag cccatggcag caaacctaat     1860

gtgtatgcca cccgggactc cgctgaggat gtggcaatgc aggtggaggc gcaggacgct     1920

gtgatggggc aggatctggc tgtctctgtg gtgctgacca atcgtggtag tagccgacgc     1980

actgtgaagt tgcacctcta cctttgtgtc acctactaca ctggtgtctc tgggcctacc     2040

ttcaaggagg ccaaaaagga agtgacatta gccccaggag cctcggactc tgtgaccatg     2100

cctgtggcct acaaggaata caagccccac cttgtggacc agggggcaat gttgctcaat     2160

gtctcaggcc atgtcaagga gagtgggcag gtactagcca agcaacacac cttccgtttg     2220

cgcaccccag acctttctct tacgttactg ggagcagcag ttgttggtca ggaatgtgga     2280

gtacagatcg tgttcaagaa ccccctgcct gtcaccctca ccaacgtcgt cttccggctc     2340

gaaggttctg gattacagag acccaaggtc ctcaatgtcg gggacatcgg gggtaatgag     2400

acagtcacac tgcgccagac gtttgttccc gtgcgaccag gcccccgcca gctcattgcc     2460

agcctggaca gtccacagct ttcccaagtg cacggtgtta ttcaagtgga tgtggcccca     2520

gcctctggag gcagcggttt ctcagatgct ggaggtgaca gtcgctctgg ggagaacata     2580

cctatggcat atcgaggtgg agcttaaccc tgggccagga gcaatgggac tggaatcaga     2640

tgaacaagga cattgcccca agatggggcc ccaccacaga gtagctcccc aggctcagac     2700

aggaagactg gggcacctgg ggaggcagtc gctcttcatt tgtgctgata ataaactggt     2760

tttttttttt taataaagat gctgtttagt aaaaaaaaaa aaaaa                     2805


<210>  179
<211>  815
<212>  PRT
<213>  Mus musculus

<400>  179

Met Glu Gly Pro Arg Ser Asp Val Gly Arg Trp Gly Arg Ser Pro Trp 
1               5                   10                  15      


Gln Pro Pro Thr Thr Pro Ser Pro Glu Pro Glu Pro Glu Pro Glu Pro 
            20                  25                  30          


Asp Arg Arg Ser Arg Ser Arg Arg Gly Gly Gly Arg Ser Phe Trp Ala 
        35                  40                  45              


Arg Cys Cys Gly Cys Cys Ser Cys Gly Asn Arg Gly Asp Asp Asp Trp 
    50                  55                  60                  


Gly Pro Glu Pro Ser Gly Ser Arg Ser Arg Gly Thr Ser Ser Arg Gly 
65                  70                  75                  80  


Arg Asp Ser Arg Gly Gly Arg Arg Pro Glu Ser Arg Gly Ser Gly Val 
                85                  90                  95      


Asn Ala Ala Gly Asp Gly Thr Ile Arg Glu Gly Met Leu Val Val Thr 
            100                 105                 110         


Gly Val Asp Leu Leu Cys Ser Arg Ser Asp Gln Asn Arg Arg Glu His 
        115                 120                 125             


His Thr Asp Glu Phe Glu Tyr Asp Glu Leu Ile Val Arg Arg Gly Gln 
    130                 135                 140                 


Pro Phe His Met Ile Leu Phe Leu Asn Arg Glu Tyr Glu Ser Ser Asp 
145                 150                 155                 160 


Arg Ile Ala Leu Glu Leu Leu Ile Gly Ser Asn Pro Glu Val Gly Lys 
                165                 170                 175     


Gly Thr His Val Ile Ile Pro Val Gly Lys Gly Gly Ser Gly Gly Trp 
            180                 185                 190         


Lys Ala Gln Val Thr Lys Asn Asn Gly His Asn Leu Asn Leu Arg Val 
        195                 200                 205             


His Thr Ser Pro Asn Ala Ile Ile Gly Lys Phe Gln Phe Thr Val Arg 
    210                 215                 220                 


Thr Arg Ser Glu Ala Gly Glu Phe Gln Leu Pro Phe Asp Pro Arg Asn 
225                 230                 235                 240 


Glu Ile Tyr Ile Leu Phe Asn Pro Trp Cys Pro Glu Asp Ile Val Tyr 
                245                 250                 255     


Val Asp His Glu Asp Trp Arg Gln Glu Tyr Val Leu Asn Glu Ser Gly 
            260                 265                 270         


Arg Ile Tyr Tyr Gly Thr Glu Ala Gln Ile Gly Glu Arg Thr Trp Asn 
        275                 280                 285             


Tyr Gly Gln Phe Asp His Gly Val Leu Asp Ala Cys Leu Tyr Ile Leu 
    290                 295                 300                 


Asp Arg Arg Gly Met Pro Tyr Gly Gly Arg Gly Asp Pro Val Ser Val 
305                 310                 315                 320 


Ser Arg Val Val Ser Ala Met Val Asn Ser Leu Asp Asp Asn Gly Val 
                325                 330                 335     


Leu Ile Gly Asn Trp Thr Gly Asp Tyr Ser Arg Gly Thr Asn Pro Ser 
            340                 345                 350         


Ala Trp Val Gly Ser Val Glu Ile Leu Leu Ser Tyr Leu Arg Thr Gly 
        355                 360                 365             


Tyr Ser Val Pro Tyr Gly Gln Cys Trp Val Phe Ala Gly Val Thr Thr 
    370                 375                 380                 


Thr Val Leu Arg Cys Leu Gly Phe Ala Thr Arg Thr Val Thr Asn Phe 
385                 390                 395                 400 


Asn Ser Ala His Asp Thr Asp Thr Ser Leu Thr Met Asp Ile Tyr Phe 
                405                 410                 415     


Asp Glu Asn Met Lys Pro Leu Glu His Leu Asn His Asp Ser Val Trp 
            420                 425                 430         


Asn Phe His Val Trp Asn Asp Cys Trp Met Lys Arg Pro Asp Leu Pro 
        435                 440                 445             


Ser Gly Phe Asp Gly Trp Gln Val Val Asp Ala Thr Pro Gln Glu Thr 
    450                 455                 460                 


Ser Ser Gly Ile Phe Cys Cys Gly Pro Cys Ser Val Glu Ser Val Lys 
465                 470                 475                 480 


Asn Gly Leu Val Tyr Met Lys Tyr Asp Thr Pro Phe Ile Phe Ala Glu 
                485                 490                 495     


Val Asn Ser Asp Lys Val Tyr Trp Gln Arg Gln Asp Asp Gly Ser Phe 
            500                 505                 510         


Lys Ile Val Tyr Val Glu Glu Lys Ala Ile Gly Thr Leu Ile Val Thr 
        515                 520                 525             


Lys Ala Ile His Ser Asn Asn Arg Glu Asp Ile Thr His Ile Tyr Lys 
    530                 535                 540                 


His Pro Glu Gly Ser Glu Ala Glu Arg Arg Ala Val Glu Lys Ala Ala 
545                 550                 555                 560 


Ala His Gly Ser Lys Pro Asn Val Tyr Ala Thr Arg Asp Ser Ala Glu 
                565                 570                 575     


Asp Val Ala Met Gln Val Glu Ala Gln Asp Ala Val Met Gly Gln Asp 
            580                 585                 590         


Leu Ala Val Ser Val Val Leu Thr Asn Arg Gly Ser Ser Arg Arg Thr 
        595                 600                 605             


Val Lys Leu His Leu Tyr Leu Cys Val Thr Tyr Tyr Thr Gly Val Ser 
    610                 615                 620                 


Gly Pro Thr Phe Lys Glu Ala Lys Lys Glu Val Thr Leu Ala Pro Gly 
625                 630                 635                 640 


Ala Ser Asp Ser Val Thr Met Pro Val Ala Tyr Lys Glu Tyr Lys Pro 
                645                 650                 655     


His Leu Val Asp Gln Gly Ala Met Leu Leu Asn Val Ser Gly His Val 
            660                 665                 670         


Lys Glu Ser Gly Gln Val Leu Ala Lys Gln His Thr Phe Arg Leu Arg 
        675                 680                 685             


Thr Pro Asp Leu Ser Leu Thr Leu Leu Gly Ala Ala Val Val Gly Gln 
    690                 695                 700                 


Glu Cys Gly Val Gln Ile Val Phe Lys Asn Pro Leu Pro Val Thr Leu 
705                 710                 715                 720 


Thr Asn Val Val Phe Arg Leu Glu Gly Ser Gly Leu Gln Arg Pro Lys 
                725                 730                 735     


Val Leu Asn Val Gly Asp Ile Gly Gly Asn Glu Thr Val Thr Leu Arg 
            740                 745                 750         


Gln Thr Phe Val Pro Val Arg Pro Gly Pro Arg Gln Leu Ile Ala Ser 
        755                 760                 765             


Leu Asp Ser Pro Gln Leu Ser Gln Val His Gly Val Ile Gln Val Asp 
    770                 775                 780                 


Val Ala Pro Ala Ser Gly Gly Ser Gly Phe Ser Asp Ala Gly Gly Asp 
785                 790                 795                 800 


Ser Arg Ser Gly Glu Asn Ile Pro Met Ala Tyr Arg Gly Gly Ala 
                805                 810                 815 


<210>  180
<211>  10919
<212>  DNA
<213>  Mus musculus

<400>  180
ccgggccatg gcgccgtcat cgccgcgcgt gctgcccgcg ctggtgttgc tggccgccgc       60

cgccctgcca gccctggagt tgggagcagc cgcttgggag ctgcgggtgc ctggcggggc      120

ccgcgccttc gctctcggac cgggctggag ctacaggttg gacaccacgc gcacgcctcg      180

ggagctgctg gacgtgagcc gcgaggggcc agcagcgggt cggaggcttg ggcttggcgc      240

ggggactctg ggctgtgccc gcttggccgg gaggctgctg ccgctgcagg tccggctggt      300

cgcccgcggc gccccgacgg ccccgagctt ggtactaagg gcacgcgcct atggtgcccg      360

ctgtggggtc cggctgttgc gccgctcggc ccgcggtgca gagctgcgct ctccggccgt      420

ccgctcagtt cctggacttg gagatgcgct ctgcttcccg gccgcaggcg gcggcgcagc      480

ctcgctgact tcggtgcttg aggccatcac caacttcccc gcctgcagct gcccgccggt      540

cgccgggacc ggctgcaggc gcggacccat ttgcctgcgg ccaggaggtt cagctgagct      600

gcgtctggtg tgcgccctgg gacgcgcggc aggcgccgtt tgggtagagc tggtaataca      660

ggcgacctct gggacgccct cagagtcgcc ctcggtgtcg ccatcgttgc ttaacctgtc      720

ccaacctcgg gcgggggtgg tgcgacggtc taggcggggc acgggcagca gcacgagccc      780

gcagttcccg ctgcccagct accaggtgtc agtgcctgag aatgagcctg cgggcactgc      840

ggtcatcgaa ctgcgcgcgc acgacccaga cgaaggcgat gcaggacgcc ttagctacca      900

gatggaggcg ctgttcgatg agcgctctaa tggctacttc ctcatcgatg ccgccacggg      960

tgcagtgacc acagcccgct ccctggaccg ggagaccaag gacactcatg tactcaaagt     1020

tagtgctgtg gaccacggct ccccgaggcg ctcagctgcc acctacctca ccgtaactgt     1080

cagtgacact aacgaccaca gcccagtctt tgagcagtct gagtatcgag agcgaattcg     1140

agaaaacctg gaggtgggct atgaggttct gaccatccgt gccaccgacg gggatgcccc     1200

ttccaacgca aacatgcgct atcgtctgct ggagggcgca ggtggtgtct ttgagataga     1260

cgcacgatca ggtgtcgtgc gcacacgggc tgtggtggac cgtgaggagg cggctgagta     1320

ccagctgctg gtggaggcca atgaccaggg tcgcaatcca ggcccactca gtgcctcagc     1380

caccgtccac atagtggtag aagacgagaa tgacaactac ccccagttca gtgagaagcg     1440

ctatgtggtt caagtcccag aagacgtagc cgtcaacacg gctgtgcttc gagtccaggc     1500

cactgaccgg gaccaggggc agaatgcagc catacactac agcatcgtta gtggcaacct     1560

gaagggtcag ttctacctgc attcgcttag tgggagcctg gatgttatca acccgctgga     1620

cttcgaagcc atccgggaat acaccctgcg catcaaagcc caagatgggg gccggcctcc     1680

tctcattaat tcctcaggac tggtctcggt gcaggtgtta gatgtgaacg acaatgcgcc     1740

catctttgtg agcagcccct ttcaggctgc cgtgctagag aatgtgcccc tcggccactc     1800

agtcctgcac atccaagcgg tggacgcaga tgcaggggag aacgccaggc tgcagtaccg     1860

tctagtggac acagcctcca ctatcgtggg gggcagcagt gtcgactctg agaaccctgc     1920

ctctgcccca gacttcccct tccaaatcca caacagctcc ggttggatta ctgtgtgcgc     1980

ggagctggac cgtgaggagg tggaacacta tagctttgga gtagaagcag tggaccatgg     2040

ctcaccagcc atgagctcct ctgccagcgt gtccatcaca gtgctggatg taaatgataa     2100

cgaccccatg ttcacgcagc ctgtgtatga gctgcgtctg aatgaggatg cggctgtcgg     2160

gagcagcgtg ctgaccctca gggcccgaga ccgtgatgcc aatagtgtga tcacctacca     2220

gctgacgggt gggaacaccc gcaaccgctt cgcactcagc agccagagcg gcggtggcct     2280

tatcaccttg gcactgcccc tggactacaa gcaggaacgg cagtatgtgc tggctgtgac     2340

cgcgtccgat ggcacgcgtt cacacaccgc gcaggtcttt atcaacgtta cagatgccaa     2400

cacccacagg ccggttttcc agagttccca ctacacggtc agtgtgagtg aagaccggcc     2460

cgtgggcacc tccatcgcta ccatcagtgc cacggatgag gatacgggtg agaacgcccg     2520

catcacctat gtgctagagg atcccgtacc acagttccgc attgacccgg acactggcac     2580

catttatacc atgacggaac tggactatga ggaccaggct gcctacacgc tggccatcac     2640

ggctcaggac aatggcattc ctcagaagtc agacactacc tctctggaga tccttatcct     2700

cgacgccaat gacaacgcgc ccaggttcct gcgagatttc taccagggtt ctgttttcga     2760

ggatgccccc ccatctacca gtgtcctcca ggtctctgct acagaccgtg actcaggccc     2820

taatggccgc ctcctgtaca ctttccaggg tggggatgat ggagatggag atttctacat     2880

tgagcccacg tctggtgtga tccgtaccca gcgccggctg gacagagaga atgtggccgt     2940

gtacaacctt tgggctctcg ctgtggatcg gggcagcccg aatcccctca gtgcgtcagt     3000

gggaattcag gtgagtgtgt tggacattaa cgacaacccc ccagtgtttg agaaggacga     3060

gctggagctg tttgtggaag agaacagccc tgtgggttca gtggtagcaa gaataagggc     3120

caacgacccg gacgaaggtc cgaatgctca gatcatttat cagatcgtgg agggcaatgt     3180

gcccgaggtc ttccagctgg acctactgag tggtgacctc cgtgccctgg tcgagttgga     3240

ttttgaggtc cggagggact atatgttggt ggtgcaggcc acgtctgctc ctctggtaag     3300

ccgggccacc gtgcacatcc gtctcctgga ccagaatgac aacccaccgg agttgcctga     3360

cttccagatc cttttcaaca actatgtcac caataaatcc aacagcttcc ccagtggtgt     3420

gatcggccgc atcccagccc acgaccctga cctatctgac agcctcaatt acacctttct     3480

gcaaggcaac gagctgagcc tgctgctgct ggatcccgcc acaggagagt tgcagctcag     3540

ccgggatctg gacaacaacc ggccactgga ggcgctcatg gaggtgtctg tgtcagatgg     3600

tatccacagc gtcaccgctc tctgcactct gcgcgtgacc atcattacag atgacatgct     3660

gaccaacagc atcactgtcc gcctggagaa catgtcgcag gagaagttcc tgtccccgct     3720

gctgtccctc tttgtagaag gggtggccac agtactgtcc accaccaagg atgacatctt     3780

cgtcttcaac atccagaacg acacggacgt cagctccaac atcctgaacg tgactttctc     3840

ggcactgctc cccggtggca cccgtggccg gttcttcccg tcagaggacc tgcaggagca     3900

gatctacctg aaccggacac tgctcaccac catctccgcc cagcgtgtgc tgccctttga     3960

tgacaacatc tgcctgaggg agccctgcga gaactacatg aagtgcgtgt ccgtgcttag     4020

gtttgacagt tcggcaccct tcattagttc caccacggtg ctcttccggc ctatccatcc     4080

catcacgggc ctgcgctgcc gctgcccgcc gggtttcacc ggggactact gcgagactga     4140

aattgatctt tgctactcca atccgtgcgg ggccaatggc cggtgccgga gccgtgaggg     4200

tggctacact tgtgagtgct tcgaggactt cactggggag cattgccagg tgaacgttcg     4260

ctcaggccgc tgtgccagcg gagtatgcaa aaacgggggc acctgcgtga acctgctcat     4320

tggaggcttc cactgtgtgt gcccgcccgg cgagtatgag catccctact gtgaagtgag     4380

caccaggagc ttcccacccc agtccttcgt taccttccga ggcctgcggc aacgcttcca     4440

cttcaccgtc tccctggcgt ttgccaccca ggacaggaat gccctgctgc tctacaatgg     4500

ccgcttcaat gagaagcacg acttcatcgc cctggagatt gtggaggagc agctgcagct     4560

cacgttctcg gcaggtgaga ccacaaccac ggtgacaccg caggttcctg gaggtgtgag     4620

cgatgggcgg tggcattcgg tgctggtgca gtactacaac aagcccaaca ttggccacct     4680

gggcctgccc cacgggccgt ctggagagaa ggtggctgtg gtgactgtgg atgactgtga     4740

cgcagcggtg gccgtgcact ttggaagtta cgtggggaac tacagctgcg ctgcccaggg     4800

cactcagagc ggctccaaga agtcactgga tctgactggt cctctgcttc tgggtggtgt     4860

ccccaacctg ccagaagact tccccgtgca cagccgtcag tttgtgggat gcatgcgaaa     4920

cctgtccatc gatggccgga ttgtggacat ggctgcgttt attgccaaca atggtaccag     4980

ggcaggctgt gcttctcaga ggaacttctg cgatgggacc tcatgccaga acgggggcac     5040

ctgtgtgaac aggtggaaca cgtacttatg tgagtgcccg ctccgctttg gtggaaagaa     5100

ctgtgaacaa gctatgccac accctcagcg cttcactggt gagagcgtcg tgttgtggag     5160

tgaccttgac atcaccatct ctgtgccttg gtacctgggg ctcatgttcc ggacccggaa     5220

ggaggatggt gtgctgatgg aagccacagc tggcacgtct tccaggctcc atctccagat     5280

tctcaacagc tacatccgct ttgaggtctc ctacggcccc tctgacgtgg catccatgca     5340

gctgtccaag tcccggataa ctgacggggg gtggcatcac ctgctcatag aactgaggag     5400

tgccaaggag ggcaaggaca tcaaatacct ggcagtcatg accttggact atgggatgga     5460

ccagagcaca gtgcagattg ggaatcagct tcctgggttg aagatgcgga ctattgtcat     5520

cggaggtgtg accgaggaca aggtctctgt ccgccatggt ttccgaggct gtatgcaggg     5580

agtgaggatg ggagagacgt ccaccaacat tgccaccctg aacatgaatg acgccctcaa     5640

ggtcagggtg aaggacggct gtgatgtgga ggacccatgt gcctcaagcc cctgccctcc     5700

ccatagaccc tgccgtgaca catgggacag ctactcctgc atctgtgaca gagggtactt     5760

tggaaaaaag tgtgtggatg cgtgtctcct gaacccctgc aagcacgtgg cagcctgtgt     5820

gcgctccccc aacactcctc gaggctactc ctgcgagtgc ggacccggcc actatgggca     5880

gtactgtgag aacaaagtcg accttccgtg ccccaaaggc tggtggggga acccggtgtg     5940

tggcccctgt cactgtgctg tcagccaagg ctttgatccc gactgcaaca agaccaatgg     6000

ccaatgccag tgcaaggaga attactacaa gcccccagcc caggatgctt gccttccctg     6060

tgactgtttc ccccacggct cccacagccg tgcctgcgac atggacactg ggcagtgtgc     6120

ctgcaagcct ggtgtcatcg gccgtcagtg caaccgctgt gataatcctt tcgcggaggt     6180

cacctcgctc ggctgtgaag tgatctacaa tgggtgtccc agagcatttg aggctggcat     6240

ctggtggcca cagacgaaat ttgggcagcc agcagcggtg ccatgcccca aaggatccgt     6300

gggtaacgca gtccggcact gcagtgggga gaagggctgg cttcccccag agctcttcaa     6360

ctgcacctct ggctcctttg tggacctcaa ggccttgaac gagaaactga accgcaacga     6420

gacaagaatg gacgggaacc ggtccctgcg gctggcaaag gctctgagga acgccacgca     6480

ggggaacagc accctctttg gcaatgatgt gcgcacggcc taccagcttc tggcccgcat     6540

cttacagcat gagagccgcc agcagggctt tgacctggca gccacccgag aggctaattt     6600

tcatgaggat gtcgtccata caggcagcgc cctcctggcc ccagctacag aggcatcgtg     6660

ggaacagatc cagcgaagcg aggctggtgc agcgcagcta ctgaggcatt tcgaggcata     6720

cttcagcaac gtggcacgaa atgtgaagag gacctatctg aggcccttcg tcatcgtcac     6780

cgccaacatg attcttgcag ttgacatctt cgacaagctg aacttcacgg gtgcccaggt     6840

gccaaggttt gaggacattc aggaagagct cccaagggag ctggagtcct ccgtgtcctt     6900

cccagctgac accttcaagc caccagagaa aaaagaaggc cccgtggtga ggctgaccaa     6960

ccggaggact accccactca cggcacaacc agagcccagg gctgagaggg aaacctcatc     7020

cagcagacgg aggagacacc ccgatgagcc tggacagttt gctgttgccc tggttgtcat     7080

ttaccggacc ctgggtcagc tgctgcctga acactatgac cccgaccatc gcagcctccg     7140

actgcctaac cggcctgtca tcaacacccc cgtggtgagt gctatggtgt acagtgaggg     7200

aaccccactc cccagctctc tgcagaggcc tatcctggtg gagttctccc tgttggagac     7260

ggaggaacga agcaaacctg tctgtgtatt ctggaaccac tccctcgaca ctggtgggac     7320

tggagggtgg tcagccaagg gctgtgaact tctgtcgagg aaccggaccc acgtcacttg     7380

ccagtgcagc cattcggcca gctgcgcggt gctcatggac atttccagac gtgagcacgg     7440

ggaggttctg cccctgaaga tcatcaccta tgccgccctg tccttgtctt tggtggccct     7500

cctggtggcc tttgtccttc tctcgctcgt tcggacactg cgctccaacc tgcacagcat     7560

ccacaagaac ctcatcgcgg ctctgttctt ctcccagctc atcttcatgg tcggcatcaa     7620

ccagactgag aacccgtttc tctgcacagt ggtcgccatc ctcctgcact acgtctccat     7680

gggcaccttc gcctggaccc ttgtggagaa cttgcatgtc taccgcatgc tgacagaagt     7740

gcgcaacatc gacactgggc ccatgcggtt ctaccacgtg gtgggctggg gcatccctgc     7800

cattgtcaca ggactggctg ttggcttgga ccctcagggc tatggaaacc ctgacttctg     7860

ctggctgtcc cttcaggata ccctgatttg gagctttgct gggcctgtcg gaacggttat     7920

aatcatcaac acggtcatct ttgtcctgtc tgcaaaggtt tcctgccaaa gaaagcacca     7980

ttattatgaa agaaaggggg ttgtctccat gctgaggacg gccttcctcc tgctgctgct     8040

cgtcactgcc acctggctgc tgggactgct ggcggtcaac agtgacactc tgagctttca     8100

ctacctcttt gctgccttca gctgcttgca gggcatcttt gtcctcctgt tccactgcgt     8160

ggcccacagg gaggtgcgga agcacctgag ggcggtgctg gcagggaaga agctgcagct     8220

ggatgactcg gccaccactc gggccactct gctaacgcgc tccctcaact gcaacaacac     8280

ctacagcgaa gggccagaca tgctccgcac cgccctgggc gagtccacag cctctctgga     8340

cagtaccacc agggatgaag gggtccagaa actcagtgtg tcctctggcc cagcccgtgg     8400

taaccatgga gaaccagata catccttcat ccctaggaac tccaaaaaag ctcacggccc     8460

tgactctgac tctgacagtg agctgtccct ggacgagcac agtagttcct acgcctcttc     8520

acacacatcg gacagcgagg atgatggcgg agaggctgaa gacaaatgga atccggctgg     8580

gggccccgcc catagcaccc caaaagcaga tgctctggcc aaccacgtcc cagctggctg     8640

gcccgacgag agcctggctg ggagtgacag tgaggagttg gacactgagc cccacctgaa     8700

ggtggagacc aaggtcagcg tggagttaca ccggcaggcg cagggcaatc actgtggcga     8760

ccggccctcc gacccggaaa gtggggtcct ggccaagcca gtggccgtgc ttagcagcca     8820

gccccaggag cagcggaaag gcatcctgaa aaacaaagtc acctacccgc cgccattgcc     8880

agagcagcca ctgaagtccc ggctgcgaga gaagctggct gattgtgagc agagccccac     8940

atcctcccgc acatcctccc ttggctctgg cgatggtgtc catgccactg actgtgtcat     9000

taccatcaag actccgagga gggagccagg ccgtgagcat ctcaatgggg tggccatgaa     9060

tgtacgcaca gggagtgccc aggccaacgg ttctgactca gagaaaccat gaggcacagt     9120

caaccccaca gactgctggt caagccctca gaccttgaag cctgcctggg actgctgcct     9180

atgggacaag caggcacctt gtgtgagggt ccctgccata gcagctggct ctacgcagac     9240

cgtccagacg ggaagccctt gaccctcata ggagctcagg gcccagactc tgacaaagtg     9300

ccaaagccac agatgtctcc agagggagac gtggacttca ttaaggctgg catagctccg     9360

tccttagact gaagacagaa tccaaaccat gctgtacaag aggccattga gccagagctg     9420

gacttggtga atcattgtac cgggcccttc aactgtcccg caggcctctc cttgtggtac     9480

aagcccatca ccaccagcct agcggtgcct ctgcaacggc aaccctgggt tttaaattgc     9540

tgtctaaaaa tgtaaataga tataaatctc tccctggact tgggagaaga tgggagctgt     9600

gtatgcttta cactgctttg actctgcagc cactggagag ccatgaaatg gcatctcact     9660

ctattgccca aggaagcttg cacagttgta cttgaatctg gaatgagtca actcagctgg     9720

tcccagtgcc caggtaggga gcatatgggc tgtgaagttg acacagcttc tgcagctgct     9780

tccggccagg gagtgtgggt gttccgctgg cctttggagc acacggcaca tgtgctgcgt     9840

atgtgtgcct cagctccatg gatccaggtc agggctcacc tgtgaggagt gggcgccata     9900

gctatgatat gaaactctga ccaccctgcc acccccacgc cccccccccc cccccgctcc     9960

tgatgcagtg aggcgactct ggagcctttc ccagtcagcc cagtgcgcag cgggaggact    10020

tctgctcctg ctcccataag ctctcagagt gctcatgttc ctgattctga gggagcccag    10080

aggtcttcca acgctgtcac ggtccttcct gccaatgttg tactttttca gactccaggg    10140

ctctctaggc aggcaggtgc tccacccctg aaatctgacc aatgacatca ctttgcttca    10200

aatgaccaat tgtgcaaaga aacaaagcca gagtgcccgt tttcaatggt taccacattc    10260

tttttggaat ctcacaccaa ggacctgtga ccagccactg agagccacgg tgcagccaag    10320

gccaagggat gggagcctgg agttactcag acacgtttac ttcagcatgg actgttgtct    10380

gaatcaggtc cccaaagtac atggggtgca cagtcgctcg gaatggagaa cctcaggcga    10440

ggcggtcaaa ggccaggact tctcaccaag ctgtgctctc agaagtgcac aggactgcta    10500

gtgactgact ggtgagatga aagcctacaa gacatggcct ggggtcacgc actgccaaga    10560

ggctgacggg aggcccaggt agcccaagga tggcaaggat acagagtgac ctagcacagg    10620

ggagcttcag tcccaggtgg tacagcaccg tgacaactcc gcaacccacg ccacctcaga    10680

aggtgaagtt tttgattcga tcacaactat tagcaaaaca aaccctgtca gttttaaact    10740

gtttttctga cctaagactt tccttgaccg taagacatgg agattttaac aggtgtattt    10800

attactgttc agcactggat ggcaacacag gtgagatgat gcatctataa taaattaaga    10860

tttttggatt tgtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa     10919


<210>  181
<211>  3034
<212>  PRT
<213>  Mus musculus

<400>  181

Met Ala Pro Ser Ser Pro Arg Val Leu Pro Ala Leu Val Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Leu Pro Ala Leu Glu Leu Gly Ala Ala Ala Trp Glu Leu 
            20                  25                  30          


Arg Val Pro Gly Gly Ala Arg Ala Phe Ala Leu Gly Pro Gly Trp Ser 
        35                  40                  45              


Tyr Arg Leu Asp Thr Thr Arg Thr Pro Arg Glu Leu Leu Asp Val Ser 
    50                  55                  60                  


Arg Glu Gly Pro Ala Ala Gly Arg Arg Leu Gly Leu Gly Ala Gly Thr 
65                  70                  75                  80  


Leu Gly Cys Ala Arg Leu Ala Gly Arg Leu Leu Pro Leu Gln Val Arg 
                85                  90                  95      


Leu Val Ala Arg Gly Ala Pro Thr Ala Pro Ser Leu Val Leu Arg Ala 
            100                 105                 110         


Arg Ala Tyr Gly Ala Arg Cys Gly Val Arg Leu Leu Arg Arg Ser Ala 
        115                 120                 125             


Arg Gly Ala Glu Leu Arg Ser Pro Ala Val Arg Ser Val Pro Gly Leu 
    130                 135                 140                 


Gly Asp Ala Leu Cys Phe Pro Ala Ala Gly Gly Gly Ala Ala Ser Leu 
145                 150                 155                 160 


Thr Ser Val Leu Glu Ala Ile Thr Asn Phe Pro Ala Cys Ser Cys Pro 
                165                 170                 175     


Pro Val Ala Gly Thr Gly Cys Arg Arg Gly Pro Ile Cys Leu Arg Pro 
            180                 185                 190         


Gly Gly Ser Ala Glu Leu Arg Leu Val Cys Ala Leu Gly Arg Ala Ala 
        195                 200                 205             


Gly Ala Val Trp Val Glu Leu Val Ile Gln Ala Thr Ser Gly Thr Pro 
    210                 215                 220                 


Ser Glu Ser Pro Ser Val Ser Pro Ser Leu Leu Asn Leu Ser Gln Pro 
225                 230                 235                 240 


Arg Ala Gly Val Val Arg Arg Ser Arg Arg Gly Thr Gly Ser Ser Thr 
                245                 250                 255     


Ser Pro Gln Phe Pro Leu Pro Ser Tyr Gln Val Ser Val Pro Glu Asn 
            260                 265                 270         


Glu Pro Ala Gly Thr Ala Val Ile Glu Leu Arg Ala His Asp Pro Asp 
        275                 280                 285             


Glu Gly Asp Ala Gly Arg Leu Ser Tyr Gln Met Glu Ala Leu Phe Asp 
    290                 295                 300                 


Glu Arg Ser Asn Gly Tyr Phe Leu Ile Asp Ala Ala Thr Gly Ala Val 
305                 310                 315                 320 


Thr Thr Ala Arg Ser Leu Asp Arg Glu Thr Lys Asp Thr His Val Leu 
                325                 330                 335     


Lys Val Ser Ala Val Asp His Gly Ser Pro Arg Arg Ser Ala Ala Thr 
            340                 345                 350         


Tyr Leu Thr Val Thr Val Ser Asp Thr Asn Asp His Ser Pro Val Phe 
        355                 360                 365             


Glu Gln Ser Glu Tyr Arg Glu Arg Ile Arg Glu Asn Leu Glu Val Gly 
    370                 375                 380                 


Tyr Glu Val Leu Thr Ile Arg Ala Thr Asp Gly Asp Ala Pro Ser Asn 
385                 390                 395                 400 


Ala Asn Met Arg Tyr Arg Leu Leu Glu Gly Ala Gly Gly Val Phe Glu 
                405                 410                 415     


Ile Asp Ala Arg Ser Gly Val Val Arg Thr Arg Ala Val Val Asp Arg 
            420                 425                 430         


Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln Gly 
        435                 440                 445             


Arg Asn Pro Gly Pro Leu Ser Ala Ser Ala Thr Val His Ile Val Val 
    450                 455                 460                 


Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Lys Arg Tyr Val 
465                 470                 475                 480 


Val Gln Val Pro Glu Asp Val Ala Val Asn Thr Ala Val Leu Arg Val 
                485                 490                 495     


Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr Ser 
            500                 505                 510         


Ile Val Ser Gly Asn Leu Lys Gly Gln Phe Tyr Leu His Ser Leu Ser 
        515                 520                 525             


Gly Ser Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Ala Ile Arg Glu 
    530                 535                 540                 


Tyr Thr Leu Arg Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu Ile 
545                 550                 555                 560 


Asn Ser Ser Gly Leu Val Ser Val Gln Val Leu Asp Val Asn Asp Asn 
                565                 570                 575     


Ala Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Ala Val Leu Glu Asn 
            580                 585                 590         


Val Pro Leu Gly His Ser Val Leu His Ile Gln Ala Val Asp Ala Asp 
        595                 600                 605             


Ala Gly Glu Asn Ala Arg Leu Gln Tyr Arg Leu Val Asp Thr Ala Ser 
    610                 615                 620                 


Thr Ile Val Gly Gly Ser Ser Val Asp Ser Glu Asn Pro Ala Ser Ala 
625                 630                 635                 640 


Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr Val 
                645                 650                 655     


Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly Val 
            660                 665                 670         


Glu Ala Val Asp His Gly Ser Pro Ala Met Ser Ser Ser Ala Ser Val 
        675                 680                 685             


Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Met Phe Thr Gln 
    690                 695                 700                 


Pro Val Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser Ser 
705                 710                 715                 720 


Val Leu Thr Leu Arg Ala Arg Asp Arg Asp Ala Asn Ser Val Ile Thr 
                725                 730                 735     


Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser Ser 
            740                 745                 750         


Gln Ser Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr Lys 
        755                 760                 765             


Gln Glu Arg Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr Arg 
    770                 775                 780                 


Ser His Thr Ala Gln Val Phe Ile Asn Val Thr Asp Ala Asn Thr His 
785                 790                 795                 800 


Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu Asp 
                805                 810                 815     


Arg Pro Val Gly Thr Ser Ile Ala Thr Ile Ser Ala Thr Asp Glu Asp 
            820                 825                 830         


Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Leu Glu Asp Pro Val Pro 
        835                 840                 845             


Gln Phe Arg Ile Asp Pro Asp Thr Gly Thr Ile Tyr Thr Met Thr Glu 
    850                 855                 860                 


Leu Asp Tyr Glu Asp Gln Ala Ala Tyr Thr Leu Ala Ile Thr Ala Gln 
865                 870                 875                 880 


Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Ser Leu Glu Ile Leu 
                885                 890                 895     


Ile Leu Asp Ala Asn Asp Asn Ala Pro Arg Phe Leu Arg Asp Phe Tyr 
            900                 905                 910         


Gln Gly Ser Val Phe Glu Asp Ala Pro Pro Ser Thr Ser Val Leu Gln 
        915                 920                 925             


Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu Tyr 
    930                 935                 940                 


Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu Pro 
945                 950                 955                 960 


Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn Val 
                965                 970                 975     


Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro Asn 
            980                 985                 990         


Pro Leu Ser Ala Ser Val Gly Ile  Gln Val Ser Val Leu  Asp Ile Asn 
        995                 1000                 1005             


Asp Asn  Pro Pro Val Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
    1010                 1015                 1020             


Glu Glu  Asn Ser Pro Val Gly  Ser Val Val Ala Arg  Ile Arg Ala 
    1025                 1030                 1035             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Ile  Tyr Gln Ile 
    1040                 1045                 1050             


Val Glu  Gly Asn Val Pro Glu  Val Phe Gln Leu Asp  Leu Leu Ser 
    1055                 1060                 1065             


Gly Asp  Leu Arg Ala Leu Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1070                 1075                 1080             


Asp Tyr  Met Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1085                 1090                 1095             


Arg Ala  Thr Val His Ile Arg  Leu Leu Asp Gln Asn  Asp Asn Pro 
    1100                 1105                 1110             


Pro Glu  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1115                 1120                 1125             


Asn Lys  Ser Asn Ser Phe Pro  Ser Gly Val Ile Gly  Arg Ile Pro 
    1130                 1135                 1140             


Ala His  Asp Pro Asp Leu Ser  Asp Ser Leu Asn Tyr  Thr Phe Leu 
    1145                 1150                 1155             


Gln Gly  Asn Glu Leu Ser Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1160                 1165                 1170             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1175                 1180                 1185             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1190                 1195                 1200             


Ala Leu  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1205                 1210                 1215             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1220                 1225                 1230             


Phe Leu  Ser Pro Leu Leu Ser  Leu Phe Val Glu Gly  Val Ala Thr 
    1235                 1240                 1245             


Val Leu  Ser Thr Thr Lys Asp  Asp Ile Phe Val Phe  Asn Ile Gln 
    1250                 1255                 1260             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1265                 1270                 1275             


Ala Leu  Leu Pro Gly Gly Thr  Arg Gly Arg Phe Phe  Pro Ser Glu 
    1280                 1285                 1290             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1295                 1300                 1305             


Ile Ser  Ala Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1310                 1315                 1320             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1325                 1330                 1335             


Phe Asp  Ser Ser Ala Pro Phe  Ile Ser Ser Thr Thr  Val Leu Phe 
    1340                 1345                 1350             


Arg Pro  Ile His Pro Ile Thr  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1355                 1360                 1365             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1370                 1375                 1380             


Ser Asn  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1385                 1390                 1395             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Gly  Glu His Cys 
    1400                 1405                 1410             


Gln Val  Asn Val Arg Ser Gly  Arg Cys Ala Ser Gly  Val Cys Lys 
    1415                 1420                 1425             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1430                 1435                 1440             


Val Cys  Pro Pro Gly Glu Tyr  Glu His Pro Tyr Cys  Glu Val Ser 
    1445                 1450                 1455             


Thr Arg  Ser Phe Pro Pro Gln  Ser Phe Val Thr Phe  Arg Gly Leu 
    1460                 1465                 1470             


Arg Gln  Arg Phe His Phe Thr  Val Ser Leu Ala Phe  Ala Thr Gln 
    1475                 1480                 1485             


Asp Arg  Asn Ala Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1490                 1495                 1500             


His Asp  Phe Ile Ala Leu Glu  Ile Val Glu Glu Gln  Leu Gln Leu 
    1505                 1510                 1515             


Thr Phe  Ser Ala Gly Glu Thr  Thr Thr Thr Val Thr  Pro Gln Val 
    1520                 1525                 1530             


Pro Gly  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Leu Val Gln 
    1535                 1540                 1545             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1550                 1555                 1560             


Pro Ser  Gly Glu Lys Val Ala  Val Val Thr Val Asp  Asp Cys Asp 
    1565                 1570                 1575             


Ala Ala  Val Ala Val His Phe  Gly Ser Tyr Val Gly  Asn Tyr Ser 
    1580                 1585                 1590             


Cys Ala  Ala Gln Gly Thr Gln  Ser Gly Ser Lys Lys  Ser Leu Asp 
    1595                 1600                 1605             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1610                 1615                 1620             


Asp Phe  Pro Val His Ser Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1625                 1630                 1635             


Leu Ser  Ile Asp Gly Arg Ile  Val Asp Met Ala Ala  Phe Ile Ala 
    1640                 1645                 1650             


Asn Asn  Gly Thr Arg Ala Gly  Cys Ala Ser Gln Arg  Asn Phe Cys 
    1655                 1660                 1665             


Asp Gly  Thr Ser Cys Gln Asn  Gly Gly Thr Cys Val  Asn Arg Trp 
    1670                 1675                 1680             


Asn Thr  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1685                 1690                 1695             


Cys Glu  Gln Ala Met Pro His  Pro Gln Arg Phe Thr  Gly Glu Ser 
    1700                 1705                 1710             


Val Val  Leu Trp Ser Asp Leu  Asp Ile Thr Ile Ser  Val Pro Trp 
    1715                 1720                 1725             


Tyr Leu  Gly Leu Met Phe Arg  Thr Arg Lys Glu Asp  Gly Val Leu 
    1730                 1735                 1740             


Met Glu  Ala Thr Ala Gly Thr  Ser Ser Arg Leu His  Leu Gln Ile 
    1745                 1750                 1755             


Leu Asn  Ser Tyr Ile Arg Phe  Glu Val Ser Tyr Gly  Pro Ser Asp 
    1760                 1765                 1770             


Val Ala  Ser Met Gln Leu Ser  Lys Ser Arg Ile Thr  Asp Gly Gly 
    1775                 1780                 1785             


Trp His  His Leu Leu Ile Glu  Leu Arg Ser Ala Lys  Glu Gly Lys 
    1790                 1795                 1800             


Asp Ile  Lys Tyr Leu Ala Val  Met Thr Leu Asp Tyr  Gly Met Asp 
    1805                 1810                 1815             


Gln Ser  Thr Val Gln Ile Gly  Asn Gln Leu Pro Gly  Leu Lys Met 
    1820                 1825                 1830             


Arg Thr  Ile Val Ile Gly Gly  Val Thr Glu Asp Lys  Val Ser Val 
    1835                 1840                 1845             


Arg His  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Glu 
    1850                 1855                 1860             


Thr Ser  Thr Asn Ile Ala Thr  Leu Asn Met Asn Asp  Ala Leu Lys 
    1865                 1870                 1875             


Val Arg  Val Lys Asp Gly Cys  Asp Val Glu Asp Pro  Cys Ala Ser 
    1880                 1885                 1890             


Ser Pro  Cys Pro Pro His Arg  Pro Cys Arg Asp Thr  Trp Asp Ser 
    1895                 1900                 1905             


Tyr Ser  Cys Ile Cys Asp Arg  Gly Tyr Phe Gly Lys  Lys Cys Val 
    1910                 1915                 1920             


Asp Ala  Cys Leu Leu Asn Pro  Cys Lys His Val Ala  Ala Cys Val 
    1925                 1930                 1935             


Arg Ser  Pro Asn Thr Pro Arg  Gly Tyr Ser Cys Glu  Cys Gly Pro 
    1940                 1945                 1950             


Gly His  Tyr Gly Gln Tyr Cys  Glu Asn Lys Val Asp  Leu Pro Cys 
    1955                 1960                 1965             


Pro Lys  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1970                 1975                 1980             


Ala Val  Ser Gln Gly Phe Asp  Pro Asp Cys Asn Lys  Thr Asn Gly 
    1985                 1990                 1995             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Pro Pro  Ala Gln Asp 
    2000                 2005                 2010             


Ala Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2015                 2020                 2025             


Ala Cys  Asp Met Asp Thr Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2030                 2035                 2040             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2045                 2050                 2055             


Thr Ser  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Arg Ala 
    2060                 2065                 2070             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Thr Lys Phe  Gly Gln Pro 
    2075                 2080                 2085             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2090                 2095                 2100             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2105                 2110                 2115             


Cys Thr  Ser Gly Ser Phe Val  Asp Leu Lys Ala Leu  Asn Glu Lys 
    2120                 2125                 2130             


Leu Asn  Arg Asn Glu Thr Arg  Met Asp Gly Asn Arg  Ser Leu Arg 
    2135                 2140                 2145             


Leu Ala  Lys Ala Leu Arg Asn  Ala Thr Gln Gly Asn  Ser Thr Leu 
    2150                 2155                 2160             


Phe Gly  Asn Asp Val Arg Thr  Ala Tyr Gln Leu Leu  Ala Arg Ile 
    2165                 2170                 2175             


Leu Gln  His Glu Ser Arg Gln  Gln Gly Phe Asp Leu  Ala Ala Thr 
    2180                 2185                 2190             


Arg Glu  Ala Asn Phe His Glu  Asp Val Val His Thr  Gly Ser Ala 
    2195                 2200                 2205             


Leu Leu  Ala Pro Ala Thr Glu  Ala Ser Trp Glu Gln  Ile Gln Arg 
    2210                 2215                 2220             


Ser Glu  Ala Gly Ala Ala Gln  Leu Leu Arg His Phe  Glu Ala Tyr 
    2225                 2230                 2235             


Phe Ser  Asn Val Ala Arg Asn  Val Lys Arg Thr Tyr  Leu Arg Pro 
    2240                 2245                 2250             


Phe Val  Ile Val Thr Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2255                 2260                 2265             


Asp Lys  Leu Asn Phe Thr Gly  Ala Gln Val Pro Arg  Phe Glu Asp 
    2270                 2275                 2280             


Ile Gln  Glu Glu Leu Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2285                 2290                 2295             


Pro Ala  Asp Thr Phe Lys Pro  Pro Glu Lys Lys Glu  Gly Pro Val 
    2300                 2305                 2310             


Val Arg  Leu Thr Asn Arg Arg  Thr Thr Pro Leu Thr  Ala Gln Pro 
    2315                 2320                 2325             


Glu Pro  Arg Ala Glu Arg Glu  Thr Ser Ser Ser Arg  Arg Arg Arg 
    2330                 2335                 2340             


His Pro  Asp Glu Pro Gly Gln  Phe Ala Val Ala Leu  Val Val Ile 
    2345                 2350                 2355             


Tyr Arg  Thr Leu Gly Gln Leu  Leu Pro Glu His Tyr  Asp Pro Asp 
    2360                 2365                 2370             


His Arg  Ser Leu Arg Leu Pro  Asn Arg Pro Val Ile  Asn Thr Pro 
    2375                 2380                 2385             


Val Val  Ser Ala Met Val Tyr  Ser Glu Gly Thr Pro  Leu Pro Ser 
    2390                 2395                 2400             


Ser Leu  Gln Arg Pro Ile Leu  Val Glu Phe Ser Leu  Leu Glu Thr 
    2405                 2410                 2415             


Glu Glu  Arg Ser Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2420                 2425                 2430             


Asp Thr  Gly Gly Thr Gly Gly  Trp Ser Ala Lys Gly  Cys Glu Leu 
    2435                 2440                 2445             


Leu Ser  Arg Asn Arg Thr His  Val Thr Cys Gln Cys  Ser His Ser 
    2450                 2455                 2460             


Ala Ser  Cys Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu His Gly 
    2465                 2470                 2475             


Glu Val  Leu Pro Leu Lys Ile  Ile Thr Tyr Ala Ala  Leu Ser Leu 
    2480                 2485                 2490             


Ser Leu  Val Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2495                 2500                 2505             


Arg Thr  Leu Arg Ser Asn Leu  His Ser Ile His Lys  Asn Leu Ile 
    2510                 2515                 2520             


Ala Ala  Leu Phe Phe Ser Gln  Leu Ile Phe Met Val  Gly Ile Asn 
    2525                 2530                 2535             


Gln Thr  Glu Asn Pro Phe Leu  Cys Thr Val Val Ala  Ile Leu Leu 
    2540                 2545                 2550             


His Tyr  Val Ser Met Gly Thr  Phe Ala Trp Thr Leu  Val Glu Asn 
    2555                 2560                 2565             


Leu His  Val Tyr Arg Met Leu  Thr Glu Val Arg Asn  Ile Asp Thr 
    2570                 2575                 2580             


Gly Pro  Met Arg Phe Tyr His  Val Val Gly Trp Gly  Ile Pro Ala 
    2585                 2590                 2595             


Ile Val  Thr Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2600                 2605                 2610             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Thr  Leu Ile Trp 
    2615                 2620                 2625             


Ser Phe  Ala Gly Pro Val Gly  Thr Val Ile Ile Ile  Asn Thr Val 
    2630                 2635                 2640             


Ile Phe  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2645                 2650                 2655             


Tyr Tyr  Glu Arg Lys Gly Val  Val Ser Met Leu Arg  Thr Ala Phe 
    2660                 2665                 2670             


Leu Leu  Leu Leu Leu Val Thr  Ala Thr Trp Leu Leu  Gly Leu Leu 
    2675                 2680                 2685             


Ala Val  Asn Ser Asp Thr Leu  Ser Phe His Tyr Leu  Phe Ala Ala 
    2690                 2695                 2700             


Phe Ser  Cys Leu Gln Gly Ile  Phe Val Leu Leu Phe  His Cys Val 
    2705                 2710                 2715             


Ala His  Arg Glu Val Arg Lys  His Leu Arg Ala Val  Leu Ala Gly 
    2720                 2725                 2730             


Lys Lys  Leu Gln Leu Asp Asp  Ser Ala Thr Thr Arg  Ala Thr Leu 
    2735                 2740                 2745             


Leu Thr  Arg Ser Leu Asn Cys  Asn Asn Thr Tyr Ser  Glu Gly Pro 
    2750                 2755                 2760             


Asp Met  Leu Arg Thr Ala Leu  Gly Glu Ser Thr Ala  Ser Leu Asp 
    2765                 2770                 2775             


Ser Thr  Thr Arg Asp Glu Gly  Val Gln Lys Leu Ser  Val Ser Ser 
    2780                 2785                 2790             


Gly Pro  Ala Arg Gly Asn His  Gly Glu Pro Asp Thr  Ser Phe Ile 
    2795                 2800                 2805             


Pro Arg  Asn Ser Lys Lys Ala  His Gly Pro Asp Ser  Asp Ser Asp 
    2810                 2815                 2820             


Ser Glu  Leu Ser Leu Asp Glu  His Ser Ser Ser Tyr  Ala Ser Ser 
    2825                 2830                 2835             


His Thr  Ser Asp Ser Glu Asp  Asp Gly Gly Glu Ala  Glu Asp Lys 
    2840                 2845                 2850             


Trp Asn  Pro Ala Gly Gly Pro  Ala His Ser Thr Pro  Lys Ala Asp 
    2855                 2860                 2865             


Ala Leu  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Glu Ser Leu 
    2870                 2875                 2880             


Ala Gly  Ser Asp Ser Glu Glu  Leu Asp Thr Glu Pro  His Leu Lys 
    2885                 2890                 2895             


Val Glu  Thr Lys Val Ser Val  Glu Leu His Arg Gln  Ala Gln Gly 
    2900                 2905                 2910             


Asn His  Cys Gly Asp Arg Pro  Ser Asp Pro Glu Ser  Gly Val Leu 
    2915                 2920                 2925             


Ala Lys  Pro Val Ala Val Leu  Ser Ser Gln Pro Gln  Glu Gln Arg 
    2930                 2935                 2940             


Lys Gly  Ile Leu Lys Asn Lys  Val Thr Tyr Pro Pro  Pro Leu Pro 
    2945                 2950                 2955             


Glu Gln  Pro Leu Lys Ser Arg  Leu Arg Glu Lys Leu  Ala Asp Cys 
    2960                 2965                 2970             


Glu Gln  Ser Pro Thr Ser Ser  Arg Thr Ser Ser Leu  Gly Ser Gly 
    2975                 2980                 2985             


Asp Gly  Val His Ala Thr Asp  Cys Val Ile Thr Ile  Lys Thr Pro 
    2990                 2995                 3000             


Arg Arg  Glu Pro Gly Arg Glu  His Leu Asn Gly Val  Ala Met Asn 
    3005                 3010                 3015             


Val Arg  Thr Gly Ser Ala Gln  Ala Asn Gly Ser Asp  Ser Glu Lys 
    3020                 3025                 3030             


Pro 
    


<210>  182
<211>  3703
<212>  DNA
<213>  Mus musculus

<400>  182
ggaggcggag actgccgcgg ctccagccgg gccacgctcc gaggcgaggg gctgcatggc       60

gcggccagcg ctgctgggcg agctgttggt gctgctactg tggaccgcca ccgtgggcca      120

agttgccgcg gccacagaag ttcagccacc tgtgacgaat ttgagcgtct ctgtcgaaaa      180

tctctgcacg ataatatgga cgtggagtcc tcctgaagga gccagtccaa attgcactct      240

cagatatttt agtcactttg atgaccaaca ggataagaaa attgctccag aaactcatcg      300

taaagaggaa ttacccctgg atgagaaaat ctgtctgcag gtgggctctc agtgtagtgc      360

caatgaaagt gagaagccta gccctttggt gaaaaagtgc atctcacccc ctgaaggtga      420

tcctgagtcc gctgtgactg agctcaagtg catttggcat aacctgagct atatgaagtg      480

ttcctggctc cctggaagga atacaagccc tgacacacac tatactctgt actattggta      540

cagcagcctg gagaaaagtc gtcaatgtga aaacatctat agagaaggtc aacacattgc      600

ttgttccttt aaattgacta aagtggaacc tagttttgaa catcagaacg ttcaaataat      660

ggtcaaggat aatgctggga aaattaggcc atcctgcaaa atagtgtctt taacttccta      720

tgtgaaacct gatcctccac atattaaaca tcttctcctc aaaaatggtg ccttattagt      780

gcagtggaag aatccacaaa attttagaag cagatgctta acttatgaag tggaggtcaa      840

taatactcaa accgaccgac ataatatttt agaggttgaa gaggacaaat gccagaattc      900

cgaatctgat agaaacatgg agggtacaag ttgtttccaa ctccctggtg ttcttgccga      960

cgctgtctac acagtcagag taagagtcaa aacaaacaag ttatgctttg atgacaacaa     1020

actgtggagt gattggagtg aagcacagag tataggtaag gagcaaaact ccaccttcta     1080

caccaccatg ttactcacca ttccagtctt tgtcgcagtg gcagtcataa tcctcctttt     1140

ttacctgaaa aggcttaaga tcattatatt tcctccaatt cctgatcctg gcaagatttt     1200

taaagaaatg tttggagacc agaatgatga taccctgcac tggaagaagt atgacatcta     1260

tgagaaacaa tccaaagaag aaacggattc tgtagtgctg atagaaaatc tgaagaaagc     1320

agctccttga tggggagaag tgatttcttt cttgccttca atgtgaccct gtgaagattt     1380

attgcattct ccatttgtta tctggggact tgttaaatag aaactgaaac tactcttgaa     1440

aaacaggcag ctcctaagag ccacaggtct tgatgtgact tttgcattga aaatccaaac     1500

caaaggagct cttcaagaaa agcagagttc ttctcgttct tgttcaatcc taaaagcaga     1560

tgttttgcca aatctccaaa ctagaggaca aagacaaggg gacaatgacc atcaattcat     1620

ctaatcagga attgtgatgg cttcctaagg aatctctgct tgctctgtat tctttatgtg     1680

gaataatatc aagaaatttt tcttgtgagg aaattcattt ggggtgtgta cactaatgct     1740

gtactagatt cccacagaac atctagcaaa caaaactgat acaatctgct gcctattgtt     1800

tgaggaccca ctgagtaatg tttgtggcta ttaaaatgca ttatcattat ccacttcaat     1860

agcattttcc tctgctttga aatttccaga aatcatcttg ggccaaggca atgacacata     1920

cagaaaagtc atgggcaact tctccaccaa ggctgattta tgttattgct ggtcttttta     1980

ggacaatgga tgcagaatga ggtagcattc gagttggaac caagaagact ctaatgatgt     2040

atgcccacct ttcatttctg ctattcaagt tttgactatg tatctagctt gtgcaaaacc     2100

cttaagtatg agggatagga cccccaccca tgggtttaca tatatttggg gctcattatt     2160

ttttagcatt ttctttatct ccggatagcc atttcctgga cttttgaact tcccatcttc     2220

tatgcttatg tcccactgtg cctgctcccc catcctcttt cttgtagcct tttgactcag     2280

tggaatcgaa gatacaattt tccttagact acctagtgga gcagggaata ctctgcatct     2340

caggtaaaaa aatgagtaca ctgaacaata tgtaattcat acgtattttg caacttacct     2400

gtgagcctgc aattatttga ggtttttgag caattggtgt ttctatgtgt tttctaaata     2460

gagatgatat cttttttttt ttcacttaga atttagctcc atttgcttga gagaggggga     2520

aaaattcata tctgtttctc tttttttgca aataagcctt aggatggctg ttttctatgc     2580

tgtaagtggt cctgtcaatt ctgtgtttta ttgagaggga gacaaatgga gctccaacta     2640

tttactcact tttgcatata ttaggtttcc aattctattc cattctcaca atataagcat     2700

atatatcccc attccaacca tttctgcaaa tttaaaacag tgagaggtac cttccttctc     2760

tttctcatac acacagatca ctagcaagga ctaaagaatt ttatatcaaa attctccagg     2820

catgtaccag ttcgggttaa taaaatgatg ccacttgtgt cttttgttct taagcaggga     2880

agataagaga ccctgctctc cacaggttgg tacaaagggg aaccttgctt ctgtggtagt     2940

agaggagcat tgtgcctgga atttcaggaa ctattggagc acggcacaat tgatgcacag     3000

gtatttcctc ctggcccttt tgggtatcag cttgcagctg ggatacaggc atcttagata     3060

ttgcagtttc tcctgctatt cactagaaag aaggcttggc tttcttgact ttcttgcata     3120

agagtgaaat actccttacc cagggtatca tagttctaag aatgaaagca ccttaaatgc     3180

cttgcacaga accaattttt tttaactact ggcctatttt aatggtggta aagagcatgt     3240

tttgaaatgc tgtggaaacc atctatgctg acagtcttgc agcatgggaa caaagacatc     3300

atattttgct tcaaattctc tttcagtagt acaatagcag ggggaaaggg gacaggtaac     3360

aggagtacct ttgttttaac agacaaaagt aatctccagg ccttagggac tcataaagat     3420

atgagtacat tgcttattgg aaacttgtag gttcacatat tattttgact aaggtatatg     3480

gatttccccc cacttacata agtaaaccca acataaggag gaccattcct tttctttcat     3540

tcagatgacc tttttctgaa tctgggcact gaagggatgc ataaaataat gttaatgttt     3600

tcagtaatgt cttcaagtag aagactttct gttgaactac ttataagaaa gtaaaataaa     3660

tattgtcttt ttgtatgtca cccaaaaaaa aaaaaaaaaa aaa                       3703


<210>  183
<211>  424
<212>  PRT
<213>  Mus musculus

<400>  183

Met Ala Arg Pro Ala Leu Leu Gly Glu Leu Leu Val Leu Leu Leu Trp 
1               5                   10                  15      


Thr Ala Thr Val Gly Gln Val Ala Ala Ala Thr Glu Val Gln Pro Pro 
            20                  25                  30          


Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Ile Ile Trp 
        35                  40                  45              


Thr Trp Ser Pro Pro Glu Gly Ala Ser Pro Asn Cys Thr Leu Arg Tyr 
    50                  55                  60                  


Phe Ser His Phe Asp Asp Gln Gln Asp Lys Lys Ile Ala Pro Glu Thr 
65                  70                  75                  80  


His Arg Lys Glu Glu Leu Pro Leu Asp Glu Lys Ile Cys Leu Gln Val 
                85                  90                  95      


Gly Ser Gln Cys Ser Ala Asn Glu Ser Glu Lys Pro Ser Pro Leu Val 
            100                 105                 110         


Lys Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala Val Thr 
        115                 120                 125             


Glu Leu Lys Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys Ser Trp 
    130                 135                 140                 


Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr His Tyr Thr Leu Tyr Tyr 
145                 150                 155                 160 


Trp Tyr Ser Ser Leu Glu Lys Ser Arg Gln Cys Glu Asn Ile Tyr Arg 
                165                 170                 175     


Glu Gly Gln His Ile Ala Cys Ser Phe Lys Leu Thr Lys Val Glu Pro 
            180                 185                 190         


Ser Phe Glu His Gln Asn Val Gln Ile Met Val Lys Asp Asn Ala Gly 
        195                 200                 205             


Lys Ile Arg Pro Ser Cys Lys Ile Val Ser Leu Thr Ser Tyr Val Lys 
    210                 215                 220                 


Pro Asp Pro Pro His Ile Lys His Leu Leu Leu Lys Asn Gly Ala Leu 
225                 230                 235                 240 


Leu Val Gln Trp Lys Asn Pro Gln Asn Phe Arg Ser Arg Cys Leu Thr 
                245                 250                 255     


Tyr Glu Val Glu Val Asn Asn Thr Gln Thr Asp Arg His Asn Ile Leu 
            260                 265                 270         


Glu Val Glu Glu Asp Lys Cys Gln Asn Ser Glu Ser Asp Arg Asn Met 
        275                 280                 285             


Glu Gly Thr Ser Cys Phe Gln Leu Pro Gly Val Leu Ala Asp Ala Val 
    290                 295                 300                 


Tyr Thr Val Arg Val Arg Val Lys Thr Asn Lys Leu Cys Phe Asp Asp 
305                 310                 315                 320 


Asn Lys Leu Trp Ser Asp Trp Ser Glu Ala Gln Ser Ile Gly Lys Glu 
                325                 330                 335     


Gln Asn Ser Thr Phe Tyr Thr Thr Met Leu Leu Thr Ile Pro Val Phe 
            340                 345                 350         


Val Ala Val Ala Val Ile Ile Leu Leu Phe Tyr Leu Lys Arg Leu Lys 
        355                 360                 365             


Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile Phe Lys Glu 
    370                 375                 380                 


Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys Lys Tyr Asp 
385                 390                 395                 400 


Ile Tyr Glu Lys Gln Ser Lys Glu Glu Thr Asp Ser Val Val Leu Ile 
                405                 410                 415     


Glu Asn Leu Lys Lys Ala Ala Pro 
            420                 


<210>  184
<211>  4981
<212>  DNA
<213>  Mus musculus

<400>  184
ttctgaggca tggagcttcc agcaggtttg gaagaaagta aagtgaattc catgatgcaa       60

caacacaagt gaggtctgtg gacacccacc aaaccaactc ctctctggca ggaattttag      120

attgacgaat actatgctgc ctttgcaaaa ggacaagaaa ctagtgccca aaagacgtgt      180

tcttcagcat ttggattaga cgtgttctca agacaatggc ttcaaaggtc tcctgcctct      240

atgtattgac cgttgtgtgc tgggccagcg ctctctggta cttgagcata accagaccta      300

cttcatccta cactggctcc aagccgttca gtcacctaac agttgccagg aaaaacttca      360

cctttggcaa cataagaact cgacctataa acccacattc ttttgaattt ctgataaatg      420

agcccaacaa gtgcgagaaa aacattcctt ttctcgtgat cctcattagc accacacaca      480

aggaatttga tgcccgccag gcaatccggg agacatgggg ggatgaaaac aacttcaaag      540

ggatcaagat agccacactt ttcctcctgg gcaaaaatgc tgatcctgtt ctgaaccaga      600

tggtggagca agagagccag atcttccatg acatcatcgt ggaggacttc attgactcct      660

accacaatct caccctcaaa accttaatgg ggatgagatg ggttgccact ttctgttcaa      720

aagccaagta cgtcatgaaa accgacagtg acatttttgt gaacatggac aaccttattt      780

ataaactcct gaaaccctct accaagccaa gaagaaggta tttcactggt tacgtcatca      840

acggcgggcc aatcagggat gtccgcagta agtggtatat gcctagagat ttgtaccctg      900

acagcaacta cccaccgttc tgttcaggga ctggctatat cttttccgct gatgtggctg      960

aactcattta caagacctcg ctccacacca ggctgcttca tcttgaagat gtgtacgtgg     1020

gactgtgtct tcgaaagctt ggcatccatc ctttccagaa tagtggcttc aatcactgga     1080

aaatggccta cagtttgtgt cggtaccgcc gcgtcatcac tgtccaccag atctctccag     1140

aagaaatgca cagaatctgg aatgacatgt caagcaagaa gcatctgaga tgttaggact     1200

tctattaatg taaataactt tcttttctaa gaaatgggga ctaagatgtt ggtatttaca     1260

ggtgtcacca agggaacatg aactggccag gggtttgtaa atgttttgct ttctgttcct     1320

agttctttct cggatcagta ttttacatgt attgggctcg gccatagaaa tggtgagaga     1380

gttagagggc cggatttcat tctcaggtcc taagacattg ccatttatat caaaaagtga     1440

ctctaaataa ctgccaggat tggtgcactg tgcatctgag ataaagatct gggccaggag     1500

atagaaactc acagtaatgc cctcatagca tctctgcaaa cgtaaatagt aattctttct     1560

ttgaaaataa aaaaatcaaa ccaagtcaga aaagatccgc agtcaggaac acacactaga     1620

tgttatcatt aatgctgtgt gctgttgtca tgtaacattt ttacatacgt tgccataaaa     1680

tgtgtataga atttgagatt ctaccaataa ttgattttat ccctagagta gggcatcaat     1740

gacgaaaaag atgggaatgt acacttgagg atcagttatc ctgtatgtat agaaaacatt     1800

tcggcataga ttcacaagaa ttaaatctgg tcagcaggtg ggttgtacat agaaatgcta     1860

ctttaagtaa acaagtaaac gttttttttt tccccagaac aaatattata tgatgccacc     1920

aaggagactc caaatgtagt accctcacct acttccttcc ataaatgcct ttaagtgcat     1980

tttatggttt ttggatcagt caggcatatg tctccatgtg tagaaaacac gttggtagga     2040

ggcccagaaa taatgcataa caattgataa aatgcaaatc taggtgtcca ttctaattaa     2100

cataagcttg gcaatagtgt acaatgcccc tttcacacat ttgcaaagca catgagaaca     2160

tctttaagga gtaccaacct tattaaaaga tgtgcccctg ctaccagtag aagaaatgct     2220

ctcttagcgt ctaaagcatt cacatatgtt tagtagcaaa agggctttga ggtgttctgg     2280

ggaatctgtg gctgagatcc gtgggaagga agactaggga agccaagttg ggatcccatt     2340

gatgccacaa atttatatgg accatttgaa caggcatctc atttttgatg tgcatctgta     2400

tgctcacttg taaaatggct aaaaagaaaa atctacctca caggtactgt gagagcaaat     2460

cacatttgct aataagtatt ttgagatctt ttagtttaag aggtgctaca taatgccatg     2520

tatcatgcat gatgctaaat gctaaaatga tttacagtaa tgataaagat ggttatccat     2580

tgtggcagca tcatcctaat ataacaattt accaaaataa agattgactg tgaactatca     2640

gcgtacctaa ttcttccaag acttgatgtt tccttggcta taagttagtt gattggggaa     2700

gcttcagttt ctcccccaca ctctctcatt ttggtgaaga atttttcact tcagtgtgtt     2760

gccttggcat cccaagatgt ttaaagcaaa aaaaaaaaaa tctattttgc tttggggagg     2820

agctttgcat aggtcttgca aaacacaact taaatcgtag gaaacatttg ccccgtattc     2880

ttaaaactct ttagaacaag tagggctaat ctactccctc agaggacgaa taagcactca     2940

gcaaatctcc acagtggcac atctaccgtt gatgcaccac tccttgtcgt gatgcaaaga     3000

aagctggaaa agttgctcat ttgagctatt ttctttgcac cttgacctct gcaaaacccc     3060

catagaagct gatagtaatg gggagtcaaa ggagtaaacg gagtcccatg atcacgtaat     3120

cccttgctag gaaacactta tattttatca tccccaaagt actgactaat atagggcttc     3180

ccatccttta atatgatggt gtcaagtgac ctgggagaag atgaagcaag acaaggtgag     3240

ccaccgtccc accatctagc ctcaaaccct atgagctcca atggctggct agcctcccac     3300

cctcgggcct ctttggcctc gcagcagcaa agctgaatgc agtctctgtc tcctgccctg     3360

gccttgcatc tcgtccatgc tcagcccagc cactttccat gtccaaaatc acacactata     3420

ataaccacat ctgtacatct atgaattgct ttatatgtgt gtgcgaagta tgtatagagc     3480

cctaatcttg aaaaggagca aaaaaaatca accagaaaat cacttgtctt aaaggactgt     3540

ttcttaactt tttttatgct acataatgcc cgtatgacaa acatgtaaat agacatccaa     3600

gagttcatgt acatatttta aaggcgcttt tcttgtcacc tcaattgtat gtacggctag     3660

aacctgcttg atatgtaaca ttttcctctg catggaactt gacgaggcaa ggccatttgt     3720

ccagtatctc aatagcctta agcatgtttg ttcgctcttt gggttttttt tttttttttt     3780

ggatgttcaa aaagaaaaaa aaatggttaa tttgtcaagg aaaagctcta attttctact     3840

tttgttaatt ctatgacaag aagctggtca aattattgtc atggttattt attaagccat     3900

ttataacatt tgtttaagaa caatatttca taataatggc agtattctgg ggctgggggt     3960

tttcactcag tggtaaagca cttgcctagc atgcaaaggg ctttgggttc agtcctcagc     4020

actgcaataa tacagttaaa ataatgtcag ccctactgtg ccagaagtca ctcaaagaat     4080

ttttctaagt actgtctggt tccccattat ttctccatta tgtactgtat aacgtcagca     4140

cctaaccttt aaagtttctt cttgtatttc ttagaggaaa agatgctttc tctttggtgc     4200

ctcatttatg tggctttgtg acccccttgg agcagtttca atctacaaca atgtactttt     4260

aaataaccag attcaaaaca tgaagatcat tttttgattt gaattaaata tggaagggca     4320

aaaccccttg tgtgataaga aatggagggg aaacaaactc tttacagaga agtcacagaa     4380

ggagtttttc aatcaaattt cttctaacaa aagacaatgg gatatttatg tacagtgtgt     4440

ggaattcatt ttctaccttt cctaatatgt gcgttcaaag cggggaattg attgtatcat     4500

ttctgtaaag gggaagatac tttttataag ccacaggtaa cttgtgaatg aaagacgaaa     4560

ttcactggag acgcttgatg ataattgaca tttaggtata ttgttatata tgactgattg     4620

tatttatgta tttatttgct caaaattgta catatggttt tgccaaaagt aactgtgtgt     4680

taaagtgcac tctttgggtt tgtagtacta tttagggtta caagggttgc caatcaagct     4740

gctaatcaga atactatttt tttgtatcgg tgttacaaca tgtgacgaat agacgacact     4800

gtcttttcat tcatcctctt tcccttcgtc ttgaaatgta aaatgttggt tgaaagcacg     4860

atgcaattgt acaggcccat ctgtcaagag gaagatcatg gtttcataag actgattttt     4920

tttttttaaa aacacctggg acaaataaac agaagaagaa ctcaaaaaaa aaaaaaaaaa     4980

a                                                                     4981


<210>  185
<211>  326
<212>  PRT
<213>  Mus musculus

<400>  185

Met Ala Ser Lys Val Ser Cys Leu Tyr Val Leu Thr Val Val Cys Trp 
1               5                   10                  15      


Ala Ser Ala Leu Trp Tyr Leu Ser Ile Thr Arg Pro Thr Ser Ser Tyr 
            20                  25                  30          


Thr Gly Ser Lys Pro Phe Ser His Leu Thr Val Ala Arg Lys Asn Phe 
        35                  40                  45              


Thr Phe Gly Asn Ile Arg Thr Arg Pro Ile Asn Pro His Ser Phe Glu 
    50                  55                  60                  


Phe Leu Ile Asn Glu Pro Asn Lys Cys Glu Lys Asn Ile Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Ile Ser Thr Thr His Lys Glu Phe Asp Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Glu Thr Trp Gly Asp Glu Asn Asn Phe Lys Gly Ile Lys Ile 
            100                 105                 110         


Ala Thr Leu Phe Leu Leu Gly Lys Asn Ala Asp Pro Val Leu Asn Gln 
        115                 120                 125             


Met Val Glu Gln Glu Ser Gln Ile Phe His Asp Ile Ile Val Glu Asp 
    130                 135                 140                 


Phe Ile Asp Ser Tyr His Asn Leu Thr Leu Lys Thr Leu Met Gly Met 
145                 150                 155                 160 


Arg Trp Val Ala Thr Phe Cys Ser Lys Ala Lys Tyr Val Met Lys Thr 
                165                 170                 175     


Asp Ser Asp Ile Phe Val Asn Met Asp Asn Leu Ile Tyr Lys Leu Leu 
            180                 185                 190         


Lys Pro Ser Thr Lys Pro Arg Arg Arg Tyr Phe Thr Gly Tyr Val Ile 
        195                 200                 205             


Asn Gly Gly Pro Ile Arg Asp Val Arg Ser Lys Trp Tyr Met Pro Arg 
    210                 215                 220                 


Asp Leu Tyr Pro Asp Ser Asn Tyr Pro Pro Phe Cys Ser Gly Thr Gly 
225                 230                 235                 240 


Tyr Ile Phe Ser Ala Asp Val Ala Glu Leu Ile Tyr Lys Thr Ser Leu 
                245                 250                 255     


His Thr Arg Leu Leu His Leu Glu Asp Val Tyr Val Gly Leu Cys Leu 
            260                 265                 270         


Arg Lys Leu Gly Ile His Pro Phe Gln Asn Ser Gly Phe Asn His Trp 
        275                 280                 285             


Lys Met Ala Tyr Ser Leu Cys Arg Tyr Arg Arg Val Ile Thr Val His 
    290                 295                 300                 


Gln Ile Ser Pro Glu Glu Met His Arg Ile Trp Asn Asp Met Ser Ser 
305                 310                 315                 320 


Lys Lys His Leu Arg Cys 
                325     


<210>  186
<211>  976
<212>  DNA
<213>  Mus musculus

<400>  186
ctcagagatg gagacagaca cactcctgct atgggtgctg ctgctctggg ttccaggttc       60

cactggtgac attgtgctga cacagtctcc tgcttcctta gctgtctctc tggggcagag      120

ggccaccatc tcatgcaggg ccagccaaag tgtcagtaca tctacctata gttatatgca      180

ctggtaccaa cagaaaccag gacagccacc caaactcctc atcaaatatg catccaacct      240

agaatctggg gtccctgcca ggttcagtgg cagtgggtct gggacagact tcaccctcaa      300

catccatcct gtggaggagg aggatactgc aacatattac tgtcagcaca gttgggagat      360

tccgtggacg ttcggtggag gcaccaacct ggaaatcaaa cgggctgatg ctgcaccaac      420

tgtatccatc ttcccaccat ccagtgagca gttaacatct ggaggtgcct cagtcgtgtg      480

cttcttgaac aacttctacc ccaaagacat caatgtcaag tggaagattg atggcagtga      540

acgacaaaat ggcgtcctga acagttggac tgatcaggac agcaaagaca gcacctacag      600

catgagcagc accctcacgt tgaccaagga cgagtatgaa cgacataaca gctatacctg      660

tgaggccact cacaagacat caacttcacc cattgtcaag agcttcaaca ggaatgagtg      720

ttagagacaa aggtcctgag acgccaccac cagctcccca gctccatcct atcttccctt      780

ctaaggtctt ggaggcttcc ccacaagcga cctaccactg ttgcggtgct ccaaacctcc      840

tccccacctc cttctcctcc tcctcccttt ccttggcttt tatcatgcta atatttgcag      900

aaaatattca ataaagtgag tctttgcact tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaa                                                      976


<210>  187
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  187

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
1               5                   10                  15      


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
        35                  40                  45              


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
65                  70                  75                  80  


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
                85                  90                  95      


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105     


<210>  188
<211>  1636
<212>  DNA
<213>  Mus musculus

<400>  188
ggcacactcg gctccgggga cagacggtta actcttgcca agtctcgccg cctctgcggc       60

tcccgggcct tgggcttccc ccctgaagca tgagcctttc ctcccgcagc cgccaacgct      120

gcgcgggtct cggacagtgc gcgccgggac tccaggcgcg cgccctcaag atcccttgtg      180

cccggagccc ggaagcttgc ggcaggcgat ctgtgggtga cagtgtctgc gagagacttt      240

gccacaccat tctgccggaa tttggagaaa aagaaccagc cgcttccagt cccctccccc      300

tccgccacca tttcggacac cctgcacact ctcgttttgg ggtaccctgt gacttccagg      360

cagcacgcga ggtccactgg ccccagctcg ggcgaccagc tgtctgggac gtgttgactc      420

atctcccatg accctgcggt gcctggagcc ctccgggaat ggagcggaca ggacgcggag      480

ccagtggggg accgcggggt tgccggagga acagtccccc gaggcggcgc gtctggcgaa      540

agccctgcgc gagctcagtc aaacaggatg gtactgggga agtatgactg ttaatgaagc      600

caaagagaaa ttaaaagagg ctccagaagg aactttcttg attagagata gttcgcattc      660

agactaccta ctaactatat ccgttaagac gtcagctgga ccgactaacc tgcggattga      720

gtaccaagat gggaaattca gattggattc tatcatatgt gtcaagtcca agcttaaaca      780

gtttgacagt gtggttcatc tgattgacta ctatgtccag atgtgcaagg ataaacggac      840

aggcccagaa gccccacgga atgggactgt tcacctgtac ctgaccaaac ctctgtatac      900

atcagcaccc actctgcagc atttctgtcg actcgccatt aacaaatgta ccggtacgat      960

ctggggactg cctttaccaa caagactaaa agattacttg gaagaatata aattccaggt     1020

ataagtattt ctctctcttt ttcgtttttt tttaaaaaaa aaaaaaaaca catgcctcat     1080

atagactatc tccgaatgca gctatgtgaa agagaaccca gaggccctcc tctggataac     1140

tgcgcagaat tctctcttaa ggacagttgg gctcagtcta acttaaaggt gtgaagatgt     1200

agctaggtat tttaaagttc cccttaggta gttttagctg aatgatgctt tctttcctat     1260

ggctgctcaa gatcaaatgg cccttttaaa tgaaacaaaa caaaacaaaa caaaacaaaa     1320

caaaaacaaa atgtcccaag gaaaggcaag agaatattcc tgtcagaatg acttgccttt     1380

gttttttggg ttcctatgca ctgggtcaaa agtccaagct ccataggaga gaaagaaagg     1440

cttccatttc caggaggaca gctgaaggag ggaaagaccc tggctgaccc aggcttcagc     1500

tccacttcta gacgcctggg gttcagtctg tgttagaacc tgttatagtt tgcatcctga     1560

tgtatctagt aggagttccg ttaagctgac catgcttgta tttatccctc gtcttatgca     1620

actaatcaaa tcaacc                                                     1636


<210>  189
<211>  4243
<212>  DNA
<213>  Mus musculus

<400>  189
gcatggtact ggggaagtat gactgttaat gaagccaaag agaaattaaa agaggctcca       60

gaaggaactt tcttgattag agatagttcg cattcagact acctactaac tatatccgtt      120

aagacgtcag ctggaccgac taacctgcgg attgagtacc aagatgggaa attcagattg      180

gattctatca tatgtgtcaa gtccaagctt aaacagtttg acagtgtggt tcatctgatt      240

gactactatg tccagatgtg caaggataaa cggacaggcc cagaagcccc acggaatggg      300

actgttcacc tgtacctgac caaacctctg tatacatcag cacccactct gcagcatttc      360

tgtcgactcg ccattaacaa atgtaccggt acgatctggg gactgccttt accaacaaga      420

ctaaaagatt acttggaaga atataaattc caggagtgtg gggaactcgt cctatctgcc      480

gacttttatg gcaagtactt tcctatacta ttggatccag tccttacaac atcatttctg      540

gcacatcatt acactgtgac cactttgaag ataaagaaac tcggggccca agggaaggtg      600

aagtagaaag gcatcgaaag gcctctcctc actgtgtcag ggctgggatt tggaaccagg      660

ccttctgatt ttaatatcag gtttaatcta tactctcaag caaggtcgtg cagccagagc      720

aactgactag aaggttccac agagaaggct atcagaggac attgacccac atgtgcatca      780

ctgatctgac tcgttccaag caaccgtagg cctcgtaggc ctctctgctg tgccctgtat      840

cactatttta tgaccctttt ctggagaggg tcaacaagcg tctcttcaat agcgagagga      900

catcaataaa gaccaaagtg gctctaccca ccggtgagcc ggtgggtttc atgaggtttg      960

cttccagcgg cctaaggtac cttgctgaac tcttaaatgg ttctaagagt tcacacgagg     1020

agtctggatt taaagaaaca cgatgaacag ttttattgaa aaccaaggct cggaaatgtt     1080

aggtgacccg ccccaagtca gcctttcaca agcagagccc agggtgctct gtgagtcacc     1140

agccggacat cacagctctc gatttcgaac atatttcctt cccacctcgc cacattccat     1200

cttgacactg agagactcaa gacatttttt ccaacatagc atcatctgtg gcaattgctt     1260

ggcaatttaa agggctccca ggaactgcat ggaacagtct taggacatgc aatcaaaccc     1320

atcagactct gggcaagctc caccagaaga gaggctgcct gcccctcgcc gattgcttta     1380

acccaagtta aaaccaagct tgggatccca tgcttgctga gatgattgac ggctgtcata     1440

ggagaaacta catctgggaa atttctcgcc aggatctact gatctcacgt cgatggaata     1500

tggagaacaa atgttggttt ggtttgccaa gcaaaagcac agcgagcacc cagcatccct     1560

gtgaatgtaa cacacatagt ttcagtttgg catctctccg ctggagtgtg gtactgtttc     1620

ctgatgaggt tccgttggct gcaaaagctt cagttacttt gtggcatggt ggaagaagaa     1680

tgcctcactg aatgcctgca cccgggcttg gctcaaacag ctcaggaaac cttacctgtt     1740

caaggctcaa tttccaaaca cttccttttc ttcctgttct tctgaactgg aagattctta     1800

aaaaaaaaaa aaaaaaaaaa caactaaaat tggatttcgg tcactgttgt tccaggacag     1860

atgggaatgt gataatactg tccttgcatg gatagggtgt aggtatatat gaaagaaggc     1920

atgcctcttt aaaaattcaa tatgccagtg atctgcattt ttatcctcta gaacaacagc     1980

aaaaggcgtt gtccaatcta atatttatat gcttgaaagt tctcaaatga tcacatatca     2040

aaattagcta tagtgactat aattaaaagc agtctcagct gggtgtgctg gcacggggct     2100

gtgatgccag ttacttggga agctgagtca ggagtgttac aagttggcaa gggtcacaag     2160

gcttgcccgg gctgcagagt gagttcaaat ccaggctggg cagcttagtg agaccatgtc     2220

tcaaaataaa aagtgtgaaa agggctggga tggagccctg tgttcttacc tagcccgtgt     2280

gaaatccaag gctcaatccg agatagggaa gaaaaagatc agacacattt ttaaagtaat     2340

gacgggtaca aagacaaagg tgcctgcgtt catctgggcc aaggtgcaag ctgttccctc     2400

atgtctcctt actcacagga cattgccctt gcactcctgg cccaagatgg ctcttgattc     2460

ttacattgct ccctttcgcc gagctatgct caaatgccaa gcaaaagcaa cttaagggaa     2520

ggagggtttg tctcatggtt agagagaaca gtcagtggag tggggtggga gtggaggtat     2580

catgcagcag cttcagtagg aagcagaggg aggtgaacgc tggggttcca ctcatcttct     2640

cctctttgtt cagtctaggg ccatagtcca ggggttgatg gcatccacaa tttggggggt     2700

ggggtgggtc ttccccactc agttgagcct ttctgggaaa accctcataa acacacccac     2760

aggtgttgat tctaaaactc gcccaattaa tgggtttgat gaacattgac cattttccat     2820

ttataacctt taaatgttgc tcacattgct ttggccaaaa tgggatcgcc caagcccatc     2880

tgaccgcaag ggaagttggg aaatgtagtc tttgttctgc acagccatgt ttgaccaact     2940

atacaattag gtttctaggg ctggagagat ggctcagtta cgtgcctttg agccaatgtg     3000

aaggtgcgag tttggatgcc cagtaaacat gcaaaagttg gttgtgactg tatccccagc     3060

actatcaggg aggagacggg gagacctctg aagctccctg gtcagctagc tgagcagaat     3120

tggtcaggta caggttcagt gaaagacctg atctaaattt taaggtagaa agccattgtg     3180

gaaggcacac agtgctaacc tctggctttc tatatgtgtg cacacatcca caggaacaag     3240

tgcattgcat acatactcgt gcacacacat acacacacct ttcaacttta attctaatag     3300

aaggagactc ctctgttgtc acttggagcc acttagacat ctgtggcttc tatttatttc     3360

cccacactag gagtcaggta caagtgaacc cattcatcag tcaagaaaaa gagagatcaa     3420

gttacttgct gagggaacac agctagttct ttgtgagcct ttggggtgtg cctttacttc     3480

tgttcccttt gtatgttgtg tgtctagttt cctgtgtgct agcactggaa tcggggtgga     3540

gatacctctg ctttctcggg gttgccacag cagactggta cctcatttca ccacaccact     3600

taagaacagg tgtccaggaa ggtgtcccat gacttgcctt tagagttcaa agcaagcaca     3660

cgtttaattt tgttcaagga attctgtgac acttattgag caatgggtag tacatttgag     3720

tgttgcttaa tcaaaactgg gaaccaggcc aatcgacatt cttaggtttg attcagatta     3780

tacctgactt gtggttaggt tagaaaaccc atccccccag actctccttt ccttccttcc     3840

ttctttcttc cttcttatgt cttaccccct cctttttttt tcttgctttt tgatacaaag     3900

tcccagatat ctcagggtga ccttgaactc accaaatagc caaacatggc ctggattctg     3960

atcccttgtt cttcatctcc caaatattgc tattcagatg tgtgccacct gccctcaaaa     4020

tctttttaat taagaaggaa attcttccaa gtacttggga gctagatgca ggataatcaa     4080

gaactcagag ggctatgtag ggactttgaa gctagccttg acaaaagaag agaagaaaac     4140

ctttattcat tatttctata atttttttcc agaggccaat gctgacacaa agacaatctc     4200

ttaaggtggc agattttcta gaaagaattt tattttaagg agg                       4243


<210>  190
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  190

Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Ala Asp Arg Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Leu Pro Glu Glu Gln Ser Pro Glu 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Ser Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Thr Leu Gln His Phe Cys Arg Leu Ala Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Thr Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210>  191
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  191

Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu Ala Pro Glu Gly 
1               5                   10                  15      


Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr Leu Leu Thr Ile 
            20                  25                  30          


Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg Ile Glu Tyr Gln 
        35                  40                  45              


Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val Lys Ser Lys Leu 
    50                  55                  60                  


Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr Tyr Val Gln Met 
65                  70                  75                  80  


Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg Asn Gly Thr Val 
                85                  90                  95      


His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala Pro Thr Leu Gln 
            100                 105                 110         


His Phe Cys Arg Leu Ala Ile Asn Lys Cys Thr Gly Thr Ile Trp Gly 
        115                 120                 125             


Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu Glu Tyr Lys Phe 
    130                 135                 140                 


Gln Glu Cys Gly Glu Leu Val Leu Ser Ala Asp Phe Tyr Gly Lys Tyr 
145                 150                 155                 160 


Phe Pro Ile Leu Leu Asp Pro Val Leu Thr Thr Ser Phe Leu Ala His 
                165                 170                 175     


His Tyr Thr Val Thr Thr Leu Lys Ile Lys Lys Leu Gly Ala Gln Gly 
            180                 185                 190         


Lys Val Lys 
        195 


<210>  192
<211>  1165
<212>  DNA
<213>  Mus musculus

<400>  192
gttgctgaag tcctcagtgt tcaaacactt gtgaaacgct gcatgtctag caaaattttc       60

tttttttatg ggaatataaa tttctgttga ggtgctgatt ttcaacctta attcttccat      120

caagaatgaa actatttaaa aattaagatg ccaacagatc acgagcagcc ctgtggtccc      180

aggcacaggt cattttgcct caatgggggg atttgttatg tgatccctac tatccccagc      240

ccattctgta ggttttatca tttgtttcta agacattgcc tacttaaacc attcgtgcaa      300

ttgggcacct tggtgtaccc agtgtttctg aaggagttta ttccattgac gcgccccaag      360

ttctcatgca gtgtgttcct gaatgcttga aatctgtttt ctgcgaatcc ttggtgggat      420

ggctagaaac ctgtgaaaaa tcatgaaatc accaaatacc atgtgatgtg tatagtctct      480

ctcctctcca ctgacagctc aatcagggga agtgaactgt tgctggcttc tctttgtctt      540

attccaagtt gggtcatgag attttccctg caccctggga aggtgcattg aaaattacac      600

cggagcacgc tgcgaagagg tttttctccc aagctccagc atcccaagcg aaagtaatct      660

gtcggcagct ttcgtggtgc tggcggtcct cctcactctt accatcgcgg cgctctgctt      720

cctgtgcagg aagggccacc ttcagagggc cagttcagtc cagtgtgaga tcagcctggt      780

agagacaaac aataccagaa cccgtcacag ccacagagaa cactgaagac atacatcccc      840

agtgaagggc atcattacct acaaaggcgg actgtggacc atacgacgag agaagcccat      900

catcatggat gtgtcccatc atttctatgg cagtcccagg atctcactct tcttgatgct      960

ctactgtttg attgttcatc gttcacatac agaaatgacg ctggtttcct gtgttgacct     1020

tgcaccctgc tactgtcatc actggcctgg aagtcagcag tatagataag gctggccctg     1080

aattcaagag actcacctgt ttttgcctac tcagagttac tggaattaaa ggcataacaa     1140

cactaaaaaa aaaaaaaaaa aaaaa                                           1165


<210>  193
<211>  750
<212>  DNA
<213>  Mus musculus

<400>  193
tgttgaggtg ctgattttca accttaattc ttccatcaag aatgaaacta tttaaaaatt       60

aagatgccaa cagatcacga gcagccctgt ggtcccaggc acaggtcatt ttgcctcaat      120

ggggggattt gttatgtgat ccctactatc cccagcccat tctgtaggtg cattgaaaat      180

tacaccggag cacgctgcga agaggttttt ctcccaagct ccagcatccc aagcgaaagt      240

aatctgtcgg cagctttcgt ggtgctggcg gtcctcctca ctcttaccat cgcggcgctc      300

tgcttcctgt gcaggaaggg ccaccttcag agggccagtt cagtccagtg tgagatcagc      360

ctggtagaga caaacaatac cagaacccgt cacagccaca gagaacactg aagacataca      420

tccccagtga agggcatcat tacctacaaa ggcggactgt ggaccatacg acgagagaag      480

cccatcatca tggatgtgtc ccatcatttc tatggcagtc ccaggatctc actcttcttg      540

atgctctact gtttgattgt tcatcgttca catacagaaa tgacgctggt ttcctgtgtt      600

gaccttgcac cctgctactg tcatcactgg cctggaagtc agcagtatag ataaggctgg      660

ccctgaattc aagagactca cctgtttttg cctactcaga gttactggaa ttaaaggcat      720

aacaacaaaa aaaaaaaaaa aaaaaaaaga                                       750


<210>  194
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  194

Met Pro Thr Asp His Glu Gln Pro Cys Gly Pro Arg His Arg Ser Phe 
1               5                   10                  15      


Cys Leu Asn Gly Gly Ile Cys Tyr Val Ile Pro Thr Ile Pro Ser Pro 
            20                  25                  30          


Phe Cys Arg Cys Ile Glu Asn Tyr Thr Gly Ala Arg Cys Glu Glu Val 
        35                  40                  45              


Phe Leu Pro Ser Ser Ser Ile Pro Ser Glu Ser Asn Leu Ser Ala Ala 
    50                  55                  60                  


Phe Val Val Leu Ala Val Leu Leu Thr Leu Thr Ile Ala Ala Leu Cys 
65                  70                  75                  80  


Phe Leu Cys Arg Lys Gly His Leu Gln Arg Ala Ser Ser Val Gln Cys 
                85                  90                  95      


Glu Ile Ser Leu Val Glu Thr Asn Asn Thr Arg Thr Arg His Ser His 
            100                 105                 110         


Arg Glu His 
        115 


<210>  195
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  195

Met Pro Thr Asp His Glu Gln Pro Cys Gly Pro Arg His Arg Ser Phe 
1               5                   10                  15      


Cys Leu Asn Gly Gly Ile Cys Tyr Val Ile Pro Thr Ile Pro Ser Pro 
            20                  25                  30          


Phe Cys Arg Cys Ile Glu Asn Tyr Thr Gly Ala Arg Cys Glu Glu Val 
        35                  40                  45              


Phe Leu Pro Ser Ser Ser Ile Pro Ser Glu Ser Asn Leu Ser Ala Ala 
    50                  55                  60                  


Phe Val Val Leu Ala Val Leu Leu Thr Leu Thr Ile Ala Ala Leu Cys 
65                  70                  75                  80  


Phe Leu Cys Arg Lys Gly His Leu Gln Arg Ala Ser Ser Val Gln Cys 
                85                  90                  95      


Glu Ile Ser Leu Val Glu Thr Asn Asn Thr Arg Thr Arg His Ser His 
            100                 105                 110         


Arg Glu His 
        115 


<210>  196
<211>  4131
<212>  DNA
<213>  Mus musculus

<400>  196
ggtctttgta aggagaccac tgagacgagc aggagcgtgg agcagcggct tctctgctgc       60

cctgactttt taagaaatct caatgaacta tttgtagaca atcactgatc ctgcctgcat      120

gatttttttt tcttgcacgg caaagacacc catcagtgtt aagtgaagat cacatcttat      180

atgcgatctt gacttttttt ttggtcttac attatatttt tatagatttt gttataatca      240

tggtgctggg aaaggtaaag agtttgacaa taagctttga ctgtcttaat gacagtaatg      300

tccccgtgta ttctagcggg gacactgtct caggaagggt aaatttagaa gttaccgggg      360

agatcagagt aaaatctctt aaaattcacg caagaggaca tgcgaaagta cggtggacgg      420

aatcaagaaa cgccggctcc aatactgcct atacacagaa ttacactgaa gaagtagaat      480

atttcaacca taaagacatc ttaattgggc acgaaagaga tgatgataat tctgaagaag      540

gcttccacac tattcattca ggaaggcatg aatatgcatt tagcttcgag cttccacaga      600

caccacttgc tacctcattc gaaggccgac atggcagtgt gcgctattgg gtgaaagccg      660

aattgcatag gccttggctt ctaccagtaa aattaaagaa ggaatttaca gtctttgagc      720

acatagatat caacactcct tcattactgt caccccaagc aggcacaaaa gaaaagacac      780

tctgttgctg gttctgcacc tcaggcccca tatccttaag tgccaagatt gaaaggaagg      840

gctacacccc aggtgaatca atccagatat ttgccgagat tgagaactgc tcttcccgaa      900

tggtagtgcc aaaggcggcc atttaccaga cgcaggcctt ctatgccaaa gggaaaatga      960

aggaagtaaa acagcttgtg gcaaacttac gtggcgagtc tttatcctct gggaagacag     1020

agacgtggaa tggcaagctg ctcaaaatcc caccggtttc accctccatc ctcgactgta     1080

gtataatccg agtggaatat tcgctaatgg tgtacgtgga tattcctggg gccatggatt     1140

tgcttctcag tttgcccctc gtcatcggga ccatccctct gcacccgttt ggtagcagaa     1200

cctcaagtgt gagcagtcag tgtagcatga gtatgaactg gctggctctg gcccttcctg     1260

aaagacctga agaacatgtt gttcgaattg cgtgtatctt tctccttcag caccacccag     1320

ctatgcagag gttgtaacgg aggaacagag acggaataat ctcgccccag tgggtgcttg     1380

tgatgatttt gagagagctc tccaaggacc actgtttgct tatatccagg agtttcggtt     1440

cctgccccca cctctctatt cagagattga tccaaatcct gatcagtcat ccgaggacag     1500

accatcatgc ccctctcgct gaagcaacac ttgactgagt caagttgaca tgggttctga     1560

actgtatctc ttccagctga ggacagagaa gtatcttgga gacacgtttg cagaggaagt     1620

ggaattgcct ttgcccagac agatggcaaa cacatgaaac aaccagtgat catgctttag     1680

aatcctacag catcatttgg ggctgttcca acatgcttga agatctgagc tttccttctt     1740

taaaactggc acatgttaag ggcagtcttc ttagcctgtg gtcatccgtg tcaagacacc     1800

attgcaaaga aggatgttgt ccttcctatt tgaaaatttg cacatgctca atgcttacat     1860

tgtgcagttc agtgtcacta cagcattttt tttccattta tgccagactc ttgatactct     1920

tacaacttgt ttatggtcag cacaacatgg aacaaaagaa agctttgaaa aactttgaca     1980

ttaaaaaaac aaaacaaaat gcactgacag gttttttttc ttagtttttt gttttgtttt     2040

gttttttggg ttttttgttt gtttgttaag ttaatgtagc ctggactcta cctgcatatg     2100

cacatgctca gaattgtcct actaggctga ccatgtatca cctcttcagc ttggatccta     2160

ctgtggattt atttacaaac atcaaatgcc ttcaagccaa tccttttgct gtatgttttg     2220

cagcctactg tagtagataa gcaacagata caaggagaaa agagacaaga ggaggaggct     2280

gacaagagac tttgtatggc tgttgtttgg ttttctgtga gagtgttgcc tttctactat     2340

tgatagcaga gcagccttgt gttactgact gcctaacatc actcaatctc aggtgaatgc     2400

atcacttgcc aaactgttgg aatgccgtct atgtttgttg cactgttatg ttgttgttgt     2460

tgttgttaat tgttgttatt tggttggatt ttttggagag ggatattcgg aaatgggaca     2520

tacacaaaac tgataaccca cccacattcc cctttttatc attacatata agaagaaaca     2580

aagctcagag tggagaaaga cagtagggcg ggcaccagca gaggcaaggg ctgttgctct     2640

ggaaaaatat ttttattatt ttaaaaacga gtggaagctg cccggtcact agggaaggga     2700

gggaaaagtg catttatttt tatacagagt tacttaatta cctccaaaac acatatgttg     2760

gaaatcagtt ttgctgatgc aaggtacttc aataagccag aatatatcaa ggtcatgatg     2820

ggggaagctt catttataca tttgctcaag tttgagagaa taaaatccca aatttgtttc     2880

caaagtgtgt aactttataa gtagaaaaac tagaatgttt gctgggataa gtagctttag     2940

tttgtacacg tgtataatat tgtttttcaa caatttttcc tgtcatctaa gaaacattga     3000

taggtctcta gctttgagta tatataggta gagcaacaca tgagtaaatt atttttaaag     3060

ataatttatg gttggattgt aaccatatac taacattcat gaaacaacta aaacccccac     3120

cttctcaaag tacaaaatag agtgattttg taagagttgg cttgtgttct tagtgacacc     3180

agcatctctg atgttacaac atcatgtgtg agatggagct tgtcatctgc ccaccttgcc     3240

ctctgcccca cagttacagt gcctgagaag actcggaacg ctggcctggt gcttgacctg     3300

gttaaatact gtcttaaagc ttcatacaaa ataggctttt ccataagtgg cctttaagaa     3360

aacatggaag ataattcatg tttgaaataa tgctgacagg gtgaagaaag cccgttgtaa     3420

aaatgaatcg cgttttaagt gattcagtta aagggtttgt gctcccatag caaactaata     3480

ctagataata aggaaatggg gtgaattatt tttttaattg ttaaatcatt ttgtgaatgt     3540

cccccacccc cagaagaagc tgatgggata tttggcataa agggcatttg gtggttttgt     3600

tttcgttggt agggattgtc tgaaaacacc tgactctgtg ttatgtctaa ctagggaaca     3660

attgttggtg tgcatggcct tgggcactca ctaccatgtt cgacaaagta ctctattagc     3720

aagaatgacc aatattctga ttaattggca ctggtgacaa aattctttta cgatttggca     3780

aaataaggtt ttacttttcc cattaattat ttctttactc tttagaggca ttatacttct     3840

aaatattggt caattcttga cataacacct gagggccaca gtcatgctct agtattcaag     3900

atagcttcct aatttttcat ttaggaaaag tcaaatccaa aatgtttgag aaacaaagtg     3960

caatattaaa tgtttgcttt atagattata ttctatggct gttgtaatct tttatttggt     4020

gctgaatatg tccttgtagg ctctgtttta agaaaaccat gtgggaaatg atttaacttt     4080

tcctattgct cttccttgtg gaaaataaaa gtgttttttt ttttctgttt t              4131


<210>  197
<211>  4102
<212>  DNA
<213>  Mus musculus

<400>  197
actgagacga gcaggagcgt ggagcagcgg cttctctgct gccctgactt tttaagaaat       60

ctcaatgaac tatttgtaga caatcactga tcctgcctgc atgatttttt ttttcttgca      120

cggcaaagac acccatcagt gttaagtgaa gatcacatct tatatgcgat cttgactttt      180

tttttggtct tacattatat ttttatagat tttgttataa tcatggtgct gggaaaggta      240

aagagtttga caataagctt tgactgtctt aatgacagta atgtccccgt gtattctagc      300

ggggacactg tctcaggaag ggtaaattta gaagttaccg gggagatcag agtaaaatct      360

cttaaaattc acgcaagggg acatgcgaaa gtacggtgga cggaatcaag aaacgccggc      420

tccaatactg cctatacaca gaattacact gaagaagtag aatatttcaa ccataaagac      480

atcttaattg ggcacgaaag agatgatgat aattctgaag aaggcttcca cactattcat      540

tcaggaaggc atgaatatgc atttagcttc gagcttccac agacaccact tgctacctca      600

ttcgaaggcc gacatggcag tgtgcgctat tgggtgaaag ccgaattgca taggccttgg      660

cttctaccag taaaattaaa gaaggaattt acagtctttg agcacataga tatcaacact      720

ccttcattac tgtcacccca agcaggcaca aaagaaaaga cactctgttg ctggttctgc      780

acctcaggcc ccatatcctt aagtgccaag attgaaagga agggctacac cccaggtgaa      840

tcaatccaga tatttgccga gattgagaac tgctcttccc gaatggtagt gccaaaggcg      900

gccatttacc agacgcaggc cttctatgcc aaagggaaaa tgaaggaagt aaaacagctt      960

gtggcaaact tacgtggcga gtctttatcc tctgggaaga cagagacgtg gaatggcaag     1020

ctgctcaaaa tcccaccggt ttcaccctcc atcctcgact gtagtataat ccgagtggaa     1080

tattcgctaa tggtgtacgt ggatattcct ggggccatgg atttgcttct cagtttgccc     1140

ctcgtcatcg ggaccatccc tctgcacccg tttggtagca gaacctcaag tgtgagcagt     1200

cagtgtagca tgagtatgaa ctggctggct ctggcccttc ctgaaagacc tgaagcacca     1260

cccagctatg cagaggctgt aacggaggaa cagagacgga ataatctcgc cccagtgggt     1320

gcttgtgatg attttgagag agctctccaa ggaccactgt ttgcttatat ccaggagttt     1380

cggttcctgc ccccacctct ctattcagag attgatccaa atcctgatca gtcatccgag     1440

gacagaccat catgcccctc tcgctgaagc aacacttgac tgagtcaagt tgacatgggt     1500

tctgaactgt atctcttcca gctgaggaca gagaagtatc ttggagacac gtttgcagag     1560

gaagtggaat tgcctttgcc cagacagatg gcaaacacat gaaacaacca gtgatcatgc     1620

tttagaatcc tacagcatca tttggggctg ttccaacatg cttgaagatc tgagctttcc     1680

ttctttaaaa ctggcacatg ttaagggcag tcttcttagc ctgtggtcat ccgtgtcaag     1740

acaccattgc aaagaaggat gttgtccttc ctatttgaaa atttgcacat gctcaatgct     1800

tacattgtgc agttcagtgt cactacagca ttttttttcc atttatgcca gactcttgat     1860

actcttacaa cttgtttatg gtcagcacaa catggaacaa aagaaagctt tgaaaaactt     1920

tgacattaaa aaaacaaaac aaaatgcact gacaggtttt ttttcttagt tttttgtttt     1980

gttttgtttt ttgggttttt tgtttgtttg ttaagttaat gtagcctgga ctctacctgc     2040

atatgcacat gctcagaatt gtcctactag gctgaccatg tatcacctct tcagcttgga     2100

tcctactgtg gatttattta caaacatcaa atgccttcaa gccaatcctt ttgctgtatg     2160

ttttgcagcc tactgtagta gataagcaac agatacaagg agaaaagaga caagaggagg     2220

aggctgacaa gagactttgt atggctgttg tttggttttc tgtgagagtg ttgcctttct     2280

actattgata gcagagcagc cttgtgttac tgactgccta acatcactca atctcaggtg     2340

aatgcatcac ttgccaaact gttggaatgc cgtctatgtt tgttgcactg ttatgttgtt     2400

gttgttgttg ttaattgttg ttatttggtt ggattttttg gagagggata ttcggaaatg     2460

ggacatacac aaaactgata acccacccac attccccttt ttatcattac atataagaag     2520

aaacaaagct cagagtggag aaagacagta gggcgggcac cagcagaggc aagggctgtt     2580

gctctggaaa aatattttta ttattttaaa aacgagtgga agctgcccgg tcactaggga     2640

agggagggaa aagtgcattt atttttatac agagttactt aattacctcc aaaacacata     2700

tgttggaaat cagttttgct gatgcaaggt acttcaataa gccagaatat atcaaggtca     2760

tgatggggga agcttcattt atacatttgc tcaagtttga gagaataaaa tcccaaattt     2820

gtttccaaag tgtgtaactt tataagtaga aaaactagaa tgtttgctgg gataagtagc     2880

tttagtttgt acacgtgtat aatattgttt ttcaacaatt tttcctgtca tctaagaaac     2940

attgataggt ctctagcttt gagtatatat aggtagagca acacatgagt aaattatttt     3000

taaagataat ttatggttgg attgtaacca tatactaaca ttcatgaaac aactaaaacc     3060

cccaccttct caaagtacaa aatagagtga ttttgtaaga gttggcttgt gttcttagtg     3120

acaccagcat ctctgatgtt acaacatcat gtgtgagatg gagcttgtca tctgcccacc     3180

ttgccctctg ccccacagtt acagtgcctg agaagactcg gaacgctggc ctggtgcttg     3240

acctggttaa atactgtctt aaagcttcat acaaaatagg cttttccata agtggccttt     3300

aagaaaacat ggaagataat tcatgtttga aataatgctg acagggtgaa gaaagcccgt     3360

tgtaaaaatg aatcgcgttt taagtgattc agttaaaggg tttgtgctcc catagcaaac     3420

taatactaga taataaggaa atggggtgaa ttattttttt aattgttaaa tcattttgtg     3480

aatgtccccc acccccagaa gaagttgatg ggatatttgg cataaagggc atttggtggt     3540

tttgttttcg ttggtaggga ttgtctgaaa acacctgact ctgtgttatg tctaactagg     3600

gaacaattgt tggtgtgcat ggccttgggc actcactacc atgttcgaca aagtactcta     3660

ttagcaagaa tgaccaatat tctgattaat tggcactggt gacaaaattc ttttacgatt     3720

tggcaaaata aggttttact tttcccatta attatttctt tactctttag aggcattata     3780

cttctaaata ttggtcaatt cttgacgtaa cacctgaggg ccacagtcat gctctagtat     3840

tcaagatagc ttcctaattt ttcatttagg aaaagtcaaa tccaaaatgt ttgagaaaca     3900

aagtgcaata ttaaatgttt gctttataga ttatattcta tggctgttgt aatcttttat     3960

ttggtgctga atatgtcctt gtaggctctg ttttaagaaa accatgtggg aaatgattta     4020

acttttccta ttgctcttcc ttgtggaaaa taaaagtgtt ttttttttct gtttttgtaa     4080

aaaaaaaaaa aaaaaaaaaa aa                                              4102


<210>  198
<211>  414
<212>  PRT
<213>  Mus musculus

<400>  198

Met Val Leu Gly Lys Val Lys Ser Leu Thr Ile Ser Phe Asp Cys Leu 
1               5                   10                  15      


Asn Asp Ser Asn Val Pro Val Tyr Ser Ser Gly Asp Thr Val Ser Gly 
            20                  25                  30          


Arg Val Asn Leu Glu Val Thr Gly Glu Ile Arg Val Lys Ser Leu Lys 
        35                  40                  45              


Ile His Ala Arg Gly His Ala Lys Val Arg Trp Thr Glu Ser Arg Asn 
    50                  55                  60                  


Ala Gly Ser Asn Thr Ala Tyr Thr Gln Asn Tyr Thr Glu Glu Val Glu 
65                  70                  75                  80  


Tyr Phe Asn His Lys Asp Ile Leu Ile Gly His Glu Arg Asp Asp Asp 
                85                  90                  95      


Asn Ser Glu Glu Gly Phe His Thr Ile His Ser Gly Arg His Glu Tyr 
            100                 105                 110         


Ala Phe Ser Phe Glu Leu Pro Gln Thr Pro Leu Ala Thr Ser Phe Glu 
        115                 120                 125             


Gly Arg His Gly Ser Val Arg Tyr Trp Val Lys Ala Glu Leu His Arg 
    130                 135                 140                 


Pro Trp Leu Leu Pro Val Lys Leu Lys Lys Glu Phe Thr Val Phe Glu 
145                 150                 155                 160 


His Ile Asp Ile Asn Thr Pro Ser Leu Leu Ser Pro Gln Ala Gly Thr 
                165                 170                 175     


Lys Glu Lys Thr Leu Cys Cys Trp Phe Cys Thr Ser Gly Pro Ile Ser 
            180                 185                 190         


Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Thr Pro Gly Glu Ser Ile 
        195                 200                 205             


Gln Ile Phe Ala Glu Ile Glu Asn Cys Ser Ser Arg Met Val Val Pro 
    210                 215                 220                 


Lys Ala Ala Ile Tyr Gln Thr Gln Ala Phe Tyr Ala Lys Gly Lys Met 
225                 230                 235                 240 


Lys Glu Val Lys Gln Leu Val Ala Asn Leu Arg Gly Glu Ser Leu Ser 
                245                 250                 255     


Ser Gly Lys Thr Glu Thr Trp Asn Gly Lys Leu Leu Lys Ile Pro Pro 
            260                 265                 270         


Val Ser Pro Ser Ile Leu Asp Cys Ser Ile Ile Arg Val Glu Tyr Ser 
        275                 280                 285             


Leu Met Val Tyr Val Asp Ile Pro Gly Ala Met Asp Leu Leu Leu Ser 
    290                 295                 300                 


Leu Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro Phe Gly Ser Arg 
305                 310                 315                 320 


Thr Ser Ser Val Ser Ser Gln Cys Ser Met Ser Met Asn Trp Leu Ala 
                325                 330                 335     


Leu Ala Leu Pro Glu Arg Pro Glu Ala Pro Pro Ser Tyr Ala Glu Val 
            340                 345                 350         


Val Thr Glu Glu Gln Arg Arg Asn Asn Leu Ala Pro Val Gly Ala Cys 
        355                 360                 365             


Asp Asp Phe Glu Arg Ala Leu Gln Gly Pro Leu Phe Ala Tyr Ile Gln 
    370                 375                 380                 


Glu Phe Arg Phe Leu Pro Pro Pro Leu Tyr Ser Glu Ile Asp Pro Asn 
385                 390                 395                 400 


Pro Asp Gln Ser Ser Glu Asp Arg Pro Ser Cys Pro Ser Arg 
                405                 410                 


<210>  199
<211>  414
<212>  PRT
<213>  Mus musculus

<400>  199

Met Val Leu Gly Lys Val Lys Ser Leu Thr Ile Ser Phe Asp Cys Leu 
1               5                   10                  15      


Asn Asp Ser Asn Val Pro Val Tyr Ser Ser Gly Asp Thr Val Ser Gly 
            20                  25                  30          


Arg Val Asn Leu Glu Val Thr Gly Glu Ile Arg Val Lys Ser Leu Lys 
        35                  40                  45              


Ile His Ala Arg Gly His Ala Lys Val Arg Trp Thr Glu Ser Arg Asn 
    50                  55                  60                  


Ala Gly Ser Asn Thr Ala Tyr Thr Gln Asn Tyr Thr Glu Glu Val Glu 
65                  70                  75                  80  


Tyr Phe Asn His Lys Asp Ile Leu Ile Gly His Glu Arg Asp Asp Asp 
                85                  90                  95      


Asn Ser Glu Glu Gly Phe His Thr Ile His Ser Gly Arg His Glu Tyr 
            100                 105                 110         


Ala Phe Ser Phe Glu Leu Pro Gln Thr Pro Leu Ala Thr Ser Phe Glu 
        115                 120                 125             


Gly Arg His Gly Ser Val Arg Tyr Trp Val Lys Ala Glu Leu His Arg 
    130                 135                 140                 


Pro Trp Leu Leu Pro Val Lys Leu Lys Lys Glu Phe Thr Val Phe Glu 
145                 150                 155                 160 


His Ile Asp Ile Asn Thr Pro Ser Leu Leu Ser Pro Gln Ala Gly Thr 
                165                 170                 175     


Lys Glu Lys Thr Leu Cys Cys Trp Phe Cys Thr Ser Gly Pro Ile Ser 
            180                 185                 190         


Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Thr Pro Gly Glu Ser Ile 
        195                 200                 205             


Gln Ile Phe Ala Glu Ile Glu Asn Cys Ser Ser Arg Met Val Val Pro 
    210                 215                 220                 


Lys Ala Ala Ile Tyr Gln Thr Gln Ala Phe Tyr Ala Lys Gly Lys Met 
225                 230                 235                 240 


Lys Glu Val Lys Gln Leu Val Ala Asn Leu Arg Gly Glu Ser Leu Ser 
                245                 250                 255     


Ser Gly Lys Thr Glu Thr Trp Asn Gly Lys Leu Leu Lys Ile Pro Pro 
            260                 265                 270         


Val Ser Pro Ser Ile Leu Asp Cys Ser Ile Ile Arg Val Glu Tyr Ser 
        275                 280                 285             


Leu Met Val Tyr Val Asp Ile Pro Gly Ala Met Asp Leu Leu Leu Ser 
    290                 295                 300                 


Leu Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro Phe Gly Ser Arg 
305                 310                 315                 320 


Thr Ser Ser Val Ser Ser Gln Cys Ser Met Ser Met Asn Trp Leu Ala 
                325                 330                 335     


Leu Ala Leu Pro Glu Arg Pro Glu Ala Pro Pro Ser Tyr Ala Glu Ala 
            340                 345                 350         


Val Thr Glu Glu Gln Arg Arg Asn Asn Leu Ala Pro Val Gly Ala Cys 
        355                 360                 365             


Asp Asp Phe Glu Arg Ala Leu Gln Gly Pro Leu Phe Ala Tyr Ile Gln 
    370                 375                 380                 


Glu Phe Arg Phe Leu Pro Pro Pro Leu Tyr Ser Glu Ile Asp Pro Asn 
385                 390                 395                 400 


Pro Asp Gln Ser Ser Glu Asp Arg Pro Ser Cys Pro Ser Arg 
                405                 410                 


<210>  200
<211>  1994
<212>  DNA
<213>  Mus musculus

<400>  200
cgaggagagg tgtggagcgg ctgagcaacg tggtctgttc gtccgcgggg aggcgacggc       60

gtttgcgctc ccccgcgtcc aaggcctagc gggtcttcag cgactgaaag gtagtcattt      120

gcagtggcgt aagggctcgc ggctagccgc gtagcgccgc cctgacctgg tctcatcatg      180

ttggtcctgt ttgaaacgtc cgttggctac gccatcttta aggttctgaa tgagaagaaa      240

cttcaagagg ttgatagttt gtggaaagaa tttgaaactc cagagaaagc aaataaaata      300

gtaaagctaa aacattttga gaaatttcag gatacagcag aagcattagc agcattcaca      360

gctctgatgg aaggcaaaat caataaacag ctgaagaaag ttttgaagaa aatagtaaaa      420

gaagcccatg aacctctggc tgtcgctgat gctaaactag gaggggtaat aaaggaaaaa      480

ttgaatctca gctgtatcca tagtcctgtt gttaatgaac ttatgagagg aatccgatca      540

caaatggatg gcttgattcc tggggtagaa ccacgtgaga tggcagccat gtgtcttgga      600

ttggcccaca gcctgtctcg atacagattg aaattcagtg ctgataaagt ggacacaatg      660

attgttcagg caatttcctt attagatgac ttggataaag aactaaacaa ctacattatg      720

cggtgtaggg aatggtatgg ctggcatttc cctgagttag ggaaaattat ttcagataat      780

ctgacatact gcaagtgttt acagaaagtt ggggacagga agaactatgc atctgcctct      840

ctctctgaat tcctgtctga ggaagtagaa gcagaagtga aagcagctgc agagatatct      900

atgggaacag aggtttctga agaagatatt tgcaacattc tacatctgtg tacgcaggta      960

attgaaattt ctgaatatag gactcagctc tatgaatatc tgcaaaatcg aatgatggcc     1020

attgcaccta acgttacagt catggttgga gaattagttg gagcacggct tattgctcat     1080

gcaggttctc ttttgaattt ggccaagcat gcagcttcta cagttcagat tcttggagca     1140

gaaaaagcac ttttcagggc cctcaaatct agacgagaca cacctaaata tggacttatt     1200

tatcatgctt ctcttgtagg ccagtcaagt cccaaacaca aaggaaagat ttctcgaatg     1260

ctggcagcca aaactgttct ggctatcaga tacgacgctt ttggtgaaga ttccagttct     1320

gcaatgggaa ttgagaacag agccaaatta gaggccaggt tgaggatttt ggaggacaga     1380

gggataagaa aaataagtgg aacaggaaag gcattagcaa aagcagaaaa gtatgaacac     1440

aaaagtgaag tgaagactta cgatccctct ggtgactcca cacttccaac ttgttctaaa     1500

aaacgcaaaa tagaagaggt agataaagag gatgaaatta ctgaaaagaa agcaaaaaaa     1560

gccaagatta aaattaaagc tgaagtagag gaggagatgg aggaggagga ggcggaggaa     1620

gaacaggtag tagaagagga gccgactgta aagaagaaaa agaagaagga taaaaagaaa     1680

cacataaagg aagagccact ttccgaggag gagccatgta ccagcacagc agttcctagt     1740

ccagagaaaa agaagaaaaa gaaaaagaag aaagatgctg aagactaatg taaaggaacc     1800

atagccctgt ccccgaacac atcatgctta cgattcagtt gggagcagag cacatcagat     1860

gctctcaaat aatcaaggga ggttgaatat ctagcttttc aagccttttt gtgtcttgac     1920

atcaactgtt gaccttagtc tttgatacac aaataaaata ttttctttgt attataaaaa     1980

aaaaaaaaaa aaaa                                                       1994


<210>  201
<211>  455
<212>  PRT
<213>  Mus musculus

<400>  201

Met Leu Val Leu Phe Glu Thr Ser Val Gly Tyr Ala Ile Phe Lys Val 
1               5                   10                  15      


Leu Asn Glu Lys Lys Leu Gln Glu Val Asp Ser Leu Trp Lys Glu Phe 
            20                  25                  30          


Glu Thr Pro Glu Lys Ala Asn Lys Ile Val Lys Leu Lys His Phe Glu 
        35                  40                  45              


Lys Phe Gln Asp Thr Ala Glu Ala Leu Ala Ala Phe Thr Ala Leu Met 
    50                  55                  60                  


Glu Gly Lys Ile Asn Lys Gln Leu Lys Lys Val Leu Lys Lys Ile Val 
65                  70                  75                  80  


Lys Glu Ala His Glu Pro Leu Ala Val Ala Asp Ala Lys Leu Gly Gly 
                85                  90                  95      


Val Ile Lys Glu Lys Leu Asn Leu Ser Cys Ile His Ser Pro Val Val 
            100                 105                 110         


Asn Glu Leu Met Arg Gly Ile Arg Ser Gln Met Asp Gly Leu Ile Pro 
        115                 120                 125             


Gly Val Glu Pro Arg Glu Met Ala Ala Met Cys Leu Gly Leu Ala His 
    130                 135                 140                 


Ser Leu Ser Arg Tyr Arg Leu Lys Phe Ser Ala Asp Lys Val Asp Thr 
145                 150                 155                 160 


Met Ile Val Gln Ala Ile Ser Leu Leu Asp Asp Leu Asp Lys Glu Leu 
                165                 170                 175     


Asn Asn Tyr Ile Met Arg Cys Arg Glu Trp Tyr Gly Trp His Phe Pro 
            180                 185                 190         


Glu Leu Gly Lys Ile Ile Ser Asp Asn Leu Thr Tyr Cys Lys Cys Leu 
        195                 200                 205             


Gln Lys Val Gly Asp Arg Lys Asn Tyr Ala Ser Ala Ser Leu Ser Glu 
    210                 215                 220                 


Phe Leu Ser Glu Glu Val Glu Ala Glu Val Lys Ala Ala Ala Glu Ile 
225                 230                 235                 240 


Ser Met Gly Thr Glu Val Ser Glu Glu Asp Ile Cys Asn Ile Leu His 
                245                 250                 255     


Leu Cys Thr Gln Val Ile Glu Ile Ser Glu Tyr Arg Thr Gln Leu Tyr 
            260                 265                 270         


Glu Tyr Leu Gln Asn Arg Met Met Ala Ile Ala Pro Asn Val Thr Val 
        275                 280                 285             


Met Val Gly Glu Leu Val Gly Ala Arg Leu Ile Ala His Ala Gly Ser 
    290                 295                 300                 


Leu Leu Asn Leu Ala Lys His Ala Ala Ser Thr Val Gln Ile Leu Gly 
305                 310                 315                 320 


Ala Glu Lys Ala Leu Phe Arg Ala Leu Lys Ser Arg Arg Asp Thr Pro 
                325                 330                 335     


Lys Tyr Gly Leu Ile Tyr His Ala Ser Leu Val Gly Gln Ser Ser Pro 
            340                 345                 350         


Lys His Lys Gly Lys Ile Ser Arg Met Leu Ala Ala Lys Thr Val Leu 
        355                 360                 365             


Ala Ile Arg Tyr Asp Ala Phe Gly Glu Asp Ser Ser Ser Ala Met Gly 
    370                 375                 380                 


Ile Glu Asn Arg Ala Lys Leu Glu Ala Arg Leu Arg Ile Leu Glu Asp 
385                 390                 395                 400 


Arg Gly Ile Arg Lys Ile Ser Gly Thr Gly Lys Ala Leu Ala Lys Ala 
                405                 410                 415     


Glu Lys Tyr Glu His Lys Ser Glu Val Lys Thr Tyr Asp Pro Ser Gly 
            420                 425                 430         


Asp Ser Thr Leu Pro Thr Cys Ser Lys Lys Arg Lys Ile Glu Glu Val 
        435                 440                 445             


Asp Lys Glu Asp Glu Ile Thr 
    450                 455 


<210>  202
<211>  2222
<212>  DNA
<213>  Mus musculus

<400>  202
ccggggaggc tgcctaccct gtccctttgc ctgctgctgg gaccatgggg gctggggcca       60

gcgctgagga gaagcactcc agagagctgg agaagaagct gaaagaggat gctgagaagg      120

atgcccgcac tgtgaaactg ctgcttctgg gtgccggtga atccgggaag agcactattg      180

tcaaacagat gaagattatc caccaggacg ggtattcgct ggaggaatgc ctcgagttca      240

ttgccatcat ctacggcaac actctgcagt ccatcctggc catcgttcgg gctatgacca      300

cgctcaacat tcagtatgga gattcagccc ggcaggatga tgcccggaag ctcatgcaca      360

tggcagatac tattgaggaa ggcacaatgc ccaaggagat gtcagacatc attcagcgct      420

tgtggaagga ctcgggtatc caagcttgct ttgaccgagc ctcagaatac cagctcaatg      480

actccgccgg ctactatctc tcagacctag agcgtctggt gactccagga tatgtgccca      540

ctgagcagga cgtgttgcgt tctcgtgtca aaaccactgg tattatcgag actcaattct      600

ccttcaagga cctcaacttc agaatgttcg atgtgggcgg gcagcgttcc gagcgcaaaa      660

agtggatcca ctgctttgag ggtgtgacgt gcatcatttt catcgctgcg ctgagcgctt      720

acgacatggt gctggtggag gacgacgaag tgaaccgaat gcacgagagc ctgcacctgt      780

tcaacagcat ctgcaatcat cgctacttcg ccacaacgtc tatcgtgctc ttcctcaaca      840

agaaggacgt tttctccgag aagataaaaa aggcacacct cagcatctgc ttccccgact      900

acgatggacc taacacttac gaggatgccg gcaactacat caaagtgcag ttcctggagc      960

ttaacatgcg acgtgatgtg aaggagatct attcccacat gacgtgcgct accgacacac     1020

agaacgtcaa gtttgtcttt gacgctgtca ccgacattat catcaaggag aacctcaaag     1080

actgcgggct cttctgaggt acctgaattc aggtgtgtct cttgccctga gattctgtag     1140

ccctgcagcc ctgtagccct gtagtcccct caaataccgt cctttccaca agctgctgct     1200

cttgtagcca cacacccaaa ggcatgaggc ttgcagtgca gaccctcccc caagtaccca     1260

actcgaccct gcttttcacc gcctggctgc actggcctct tggacctaca gcagccagcc     1320

tgagctagga cacctcagga cttgggacag ctggaactca cagtgactca gcagtgccct     1380

agtgacccgt ctgtctccag cctcttctgc tacccccagc agcagcagca gctcaccagc     1440

agatccccat tccacaaaca gccctccctc accagtttcc acgaaggact tgaggtatcc     1500

ctccctcaag cagtaggccg gtccagcctg ctacctgcat atgacaagtc caacacgtgt     1560

ccacccagtg gttagtgact gtccctccca gtagcctgag gactccaaag tccaagctct     1620

ggtttttgaa gcctcgtata gagaagtgag tgactttgac gtgggtgcca gggaaagaaa     1680

gacacaagcc aaacccattc ccgaacatca gactcagggt ttctccagtc ccttctccct     1740

ctgggtcttg cccctctgtc cttggacact tccacaccac acctcatcca cccacacaca     1800

atactcaggg ctggctggtc aaggtatgct gtattgaagg agggtattat tgacatagct     1860

atgaccaata atgaagccat gctgaggggt ggctcagagc agagtccaac ccctattgat     1920

caaccatggg caaagaatat cccatgtgag gttacaggca attccatgtg accatgttgt     1980

ccctcctgat tcagggccca ttccttagga gggagaactg aaaaccaggc ctaaaccatt     2040

agagacaatg tcccccaacc cccagccact tctacaacct ttgcttaagc ctgtggacca     2100

gagccagtgc tgctggaaga ggcaagatgc ttctggacag caagactagg gcacaacctc     2160

tccctccctt agctagctgc agactcagca ataaaccttt gcaccagaaa aaaaaaaaaa     2220

aa                                                                    2222


<210>  203
<211>  349
<212>  PRT
<213>  Mus musculus

<400>  203

Gly Ala Gly Ala Ser Ala Glu Glu Lys His Ser Arg Glu Leu Glu Lys 
1               5                   10                  15      


Lys Leu Lys Glu Asp Ala Glu Lys Asp Ala Arg Thr Val Lys Leu Leu 
            20                  25                  30          


Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met 
        35                  40                  45              


Lys Ile Ile His Gln Asp Gly Tyr Ser Leu Glu Glu Cys Leu Glu Phe 
    50                  55                  60                  


Ile Ala Ile Ile Tyr Gly Asn Thr Leu Gln Ser Ile Leu Ala Ile Val 
65                  70                  75                  80  


Arg Ala Met Thr Thr Leu Asn Ile Gln Tyr Gly Asp Ser Ala Arg Gln 
                85                  90                  95      


Asp Asp Ala Arg Lys Leu Met His Met Ala Asp Thr Ile Glu Glu Gly 
            100                 105                 110         


Thr Met Pro Lys Glu Met Ser Asp Ile Ile Gln Arg Leu Trp Lys Asp 
        115                 120                 125             


Ser Gly Ile Gln Ala Cys Phe Asp Arg Ala Ser Glu Tyr Gln Leu Asn 
    130                 135                 140                 


Asp Ser Ala Gly Tyr Tyr Leu Ser Asp Leu Glu Arg Leu Val Thr Pro 
145                 150                 155                 160 


Gly Tyr Val Pro Thr Glu Gln Asp Val Leu Arg Ser Arg Val Lys Thr 
                165                 170                 175     


Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe Lys Asp Leu Asn Phe Arg 
            180                 185                 190         


Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile His 
        195                 200                 205             


Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Ile Ala Ala Leu Ser Ala 
    210                 215                 220                 


Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val Asn Arg Met His Glu 
225                 230                 235                 240 


Ser Leu His Leu Phe Asn Ser Ile Cys Asn His Arg Tyr Phe Ala Thr 
                245                 250                 255     


Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp Val Phe Ser Glu Lys 
            260                 265                 270         


Ile Lys Lys Ala His Leu Ser Ile Cys Phe Pro Asp Tyr Asp Gly Pro 
        275                 280                 285             


Asn Thr Tyr Glu Asp Ala Gly Asn Tyr Ile Lys Val Gln Phe Leu Glu 
    290                 295                 300                 


Leu Asn Met Arg Arg Asp Val Lys Glu Ile Tyr Ser His Met Thr Cys 
305                 310                 315                 320 


Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe Asp Ala Val Thr Asp 
                325                 330                 335     


Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly Leu Phe 
            340                 345                 


<210>  204
<211>  2002
<212>  DNA
<213>  Mus musculus

<400>  204
ccacgcgtcc gcaccgaccc ctgcccagcc agcctcctcg cccccaacgg gagcccgcgc       60

aggtggcagc gcgcctaccg tgagcacggc tgcaggagtc ccggaggtcc gtgctcggcg      120

caggcatgat cggccagaag accctatact ctttcttctc tccgaccccc acagggaagc      180

ggaccacgcg cagcccggag ccggtcccag ggagcggagt ggcggccgag atcggcggcg      240

atgccgtggc cagccccgcc aagaaggccc gggtggagca gaacgagcaa ggctcgccgc      300

tcagcgccga gcagctcgtc cgcatccaga ggaacaaggc cgcggcgctg ctcaggctcg      360

ccgcccgcaa cgtgcctgcc ggcttcggcg agagctggaa gcagcagctg tgcggggagt      420

tcgggaagcc gtacttcgtc aagctaatgg gatttgttgc tgaagaaagg aaccaccaca      480

aggtctatcc gcccccggag caggtgttca catggaccca gatgtgcgac atccgagatg      540

tgaaggttgt cattctggga caggatccct atcacggacc taatcaagct cacgggctct      600

gcttcagtgt ccaaagacca gttccacccc cgcccagttt ggaaaacatt tttaaagagc      660

tgtctacaga catcgatggt tttgttcatc ctggccatgg ggatttgtca gggtgggccc      720

gacaaggtgt cctcctcctc aacgccgtcc tcactgtccg cgcccaccaa gccaattccc      780

ataaggagag gggctgggag cagttcacgg acgcggtcgt gtcctggctg aatcagaacc      840

tgagtggcct cgtcttcctc ctctggggct cttatgctca gaagaagggc agtgtcattg      900

acaggaagcg tcaccatgtt ctgcagacag ctcacccctc cccgctgtcg gtgcacagag      960

ggttcctggg atgcagacat ttttctaaag ccaatgaact gctccagaag tctggcaaga     1020

agcccatcaa ctggaaggag ctgtgacccg cctgcccaca ggccgcgtct gtccacagcg     1080

gtgctttcag ctgccgccgc agcttttgct ggttaagttc taagttcctt gtgtgagcgg     1140

agaaatgaca cggatagatc tctataggac catcatgagc caaccaggac acagaaactg     1200

cagctcttgc aggcagaacc tcttgcctgg cactaggttt gaactctcca ggccccgcca     1260

ggtggctgtt gagacacacc tacttctcag accagcggac acaccttcgg tcccgtgtgc     1320

tgctctgggg tgggaggaga gatctgtacc tttggaccag cagtttggtg cctgctgctg     1380

tccgctttat cctttagagt tagagatttc aaagtgtgtg tgtgtgtgtg tgtgtgtgtg     1440

tgtgtgtgtg tgtgtgcttc aaaaggccct tttgtctgga aaggaaccct tgggtgttgg     1500

tgagtcctga gaagtctggc ttacaactga atgagcttcc tgatcacaaa gggggcgggg     1560

ttctccctgg gttcacagta gccgctctcc accctgcgtc ttgcctttgc ctttgcaggc     1620

tccgaagttg agcgaagcag gaatgggata gatttgtttt taagtgaggg tgggtgggtt     1680

tcctggtgcc cgtggagttg tttcctcctc tctgcagaca gcagactgcc gcgcgtagtg     1740

tgtgtggtgc tggggatcta actccaaggt gctgtttctt agaggctgag ttcacacaag     1800

ttgtctttct gcaacactgg agaacgttat ttttttttac aaggtaggca ggtacagtaa     1860

tttctttttc atgcttttct gaaagacaat cttcactgag tttacaagct ggattccgtg     1920

agtccagctg gttagagccg tggcctgcct gaccaggcta ataaaagatg gttgacaatt     1980

gaaaaaaaaa aaaaaaaaaa aa                                              2002


<210>  205
<211>  1849
<212>  DNA
<213>  Mus musculus

<400>  205
gggttcccct gctcggctgg accatgggcg tcttggggcg gcggtctttg cggttggcgc       60

ggagagcggg gctccggagc ctgactccca accccgactc tgactcccgg caggccagcc      120

ccgccaagaa ggcccgggtg gagcagaacg agcaaggctc gccgctcagc gccgagcagc      180

tcgtccgcat ccagaggaac aaggccgcgg cgctgctcag gctcgccgcc cgcaacgtgc      240

ctgccggctt cggcgagagc tggaagcagc agctgtgcgg ggagttcggg aagccgtact      300

tcgtcaagct aatgggattt gttgctgaag aaaggaacca ccacaaggtc tatccgcccc      360

cggagcaggt gttcacatgg acccagatgt gcgacatccg agatgtgaag gttgtcattc      420

tgggacagga tccctatcac ggacctaatc aagctcacgg gctctgcttc agtgtccaaa      480

gaccagttcc acccccgccc agtttggaaa acatttttaa agagctgtct acagacatcg      540

atggttttgt tcatcctggc catggggatt tgtcagggtg ggcccgacaa ggtgtcctcc      600

tcctcaacgc cgtcctcact gtccgcgccc accaagccaa ttcccataag gagaggggct      660

gggagcagtt cacggacgcg gtcgtgtcct ggctgaatca gaacctgagt ggcctcgtct      720

tcctcctctg gggctcttat gctcagaaga agggcagtgt cattgacagg aagcgtcacc      780

atgtcctgca gacagctcac ccctccccgc tgtcggtgca cagagggttc ctgggatgca      840

gacatttttc taaagccaat gaactgctcc agaagtctgg caagaagccc atcaactgga      900

aggagctgtg acccgcccac ccgcccacag gccgcatctg tccacagcgg tgctttcagc      960

tgccgccgca gcttttgctg gttaagttct aagttccttg tgtgagtgga gaaatgacac     1020

ggatagatct ctataggacc atcatgagcc aaccaggaca cagaaactgc agctctggca     1080

ggcagaacct cttgcctggc actaggtttg aactctccag gcccggccag gtggctgttg     1140

agacacacct acttctcaga ccagcggaca caccctcggt cccgtgtgct gctctggggt     1200

gggaggaaag atctgcacct ttggaccagc agtttggtgc ctgctgctgt ccgctttatc     1260

ctttagagtt agagatttca aagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     1320

gtgtgtgtgt gcttcaaaag gcccttttgt ctggaaagga acccttgggt gttggtgagt     1380

cctgagaagt ctggcttaca actgaatgag cttcctgatc acaaaggggg cggggttctc     1440

cctgggttca cagtggccgc tctccaccct gcgtcttgcc tttgcctttg caggctccga     1500

agttgagcga agcaggaatg ggatagattt gtttttaagt gagggtgggt gggtttcctg     1560

gtggcggtgg agttgtttcc tcctctctgc agacagcaga ctgccgcgct tggtgtgtgt     1620

ggtgctgggg atctaactcc aaggtgctgt ttcttagggg ctgagttcac acaagttgtc     1680

tttctgcaac actggagaac gttatttttt tttacaaggt aggcaggtac agtaatttct     1740

ttttcatgct tttctgaaag acaatcttca ctgagtttac aagctggatt ccgtgagtcc     1800

agctggttag agccgtggcc tgcctgacca ggctaataaa agatggttg                 1849


<210>  206
<211>  199
<212>  PRT
<213>  Mus musculus

<400>  206

Met Gly Phe Val Ala Glu Glu Arg Asn His His Lys Val Tyr Pro Pro 
1               5                   10                  15      


Pro Glu Gln Val Phe Thr Trp Thr Gln Met Cys Asp Ile Arg Asp Val 
            20                  25                  30          


Lys Val Val Ile Leu Gly Gln Asp Pro Tyr His Gly Pro Asn Gln Ala 
        35                  40                  45              


His Gly Leu Cys Phe Ser Val Gln Arg Pro Val Pro Pro Pro Pro Ser 
    50                  55                  60                  


Leu Glu Asn Ile Phe Lys Glu Leu Ser Thr Asp Ile Asp Gly Phe Val 
65                  70                  75                  80  


His Pro Gly His Gly Asp Leu Ser Gly Trp Ala Arg Gln Gly Val Leu 
                85                  90                  95      


Leu Leu Asn Ala Val Leu Thr Val Arg Ala His Gln Ala Asn Ser His 
            100                 105                 110         


Lys Glu Arg Gly Trp Glu Gln Phe Thr Asp Ala Val Val Ser Trp Leu 
        115                 120                 125             


Asn Gln Asn Leu Ser Gly Leu Val Phe Leu Leu Trp Gly Ser Tyr Ala 
    130                 135                 140                 


Gln Lys Lys Gly Ser Val Ile Asp Arg Lys Arg His His Val Leu Gln 
145                 150                 155                 160 


Thr Ala His Pro Ser Pro Leu Ser Val Tyr Arg Gly Phe Leu Gly Cys 
                165                 170                 175     


Arg His Phe Ser Lys Ala Asn Glu Leu Leu Gln Lys Ser Gly Lys Lys 
            180                 185                 190         


Pro Ile Asn Trp Lys Glu Leu 
        195                 


<210>  207
<211>  295
<212>  PRT
<213>  Mus musculus

<400>  207

Met Gly Val Leu Gly Arg Arg Ser Leu Arg Leu Ala Arg Arg Ala Gly 
1               5                   10                  15      


Leu Arg Ser Leu Thr Pro Asn Pro Asp Ser Asp Ser Arg Gln Ala Ser 
            20                  25                  30          


Pro Ala Lys Lys Ala Arg Val Glu Gln Asn Glu Gln Gly Ser Pro Leu 
        35                  40                  45              


Ser Ala Glu Gln Leu Val Arg Ile Gln Arg Asn Lys Ala Ala Ala Leu 
    50                  55                  60                  


Leu Arg Leu Ala Ala Arg Asn Val Pro Ala Gly Phe Gly Glu Ser Trp 
65                  70                  75                  80  


Lys Gln Gln Leu Cys Gly Glu Phe Gly Lys Pro Tyr Phe Val Lys Leu 
                85                  90                  95      


Met Gly Phe Val Ala Glu Glu Arg Asn His His Lys Val Tyr Pro Pro 
            100                 105                 110         


Pro Glu Gln Val Phe Thr Trp Thr Gln Met Cys Asp Ile Arg Asp Val 
        115                 120                 125             


Lys Val Val Ile Leu Gly Gln Asp Pro Tyr His Gly Pro Asn Gln Ala 
    130                 135                 140                 


His Gly Leu Cys Phe Ser Val Gln Arg Pro Val Pro Pro Pro Pro Ser 
145                 150                 155                 160 


Leu Glu Asn Ile Phe Lys Glu Leu Ser Thr Asp Ile Asp Gly Phe Val 
                165                 170                 175     


His Pro Gly His Gly Asp Leu Ser Gly Trp Ala Arg Gln Gly Val Leu 
            180                 185                 190         


Leu Leu Asn Ala Val Leu Thr Val Arg Ala His Gln Ala Asn Ser His 
        195                 200                 205             


Lys Glu Arg Gly Trp Glu Gln Phe Thr Asp Ala Val Val Ser Trp Leu 
    210                 215                 220                 


Asn Gln Asn Leu Ser Gly Leu Val Phe Leu Leu Trp Gly Ser Tyr Ala 
225                 230                 235                 240 


Gln Lys Lys Gly Ser Val Ile Asp Arg Lys Arg His His Val Leu Gln 
                245                 250                 255     


Thr Ala His Pro Ser Pro Leu Ser Val His Arg Gly Phe Leu Gly Cys 
            260                 265                 270         


Arg His Phe Ser Lys Ala Asn Glu Leu Leu Gln Lys Ser Gly Lys Lys 
        275                 280                 285             


Pro Ile Asn Trp Lys Glu Leu 
    290                 295 


<210>  208
<211>  1548
<212>  DNA
<213>  Mus musculus

<400>  208
gccacgggct cagtcttcct ctcccgaaaa aggagaccta ccgtacttgt tttttttttt       60

ctcctgcacg tgaagggcga gttccacttg ctgatcgaat aaagtcagag atccagaaat      120

tccagtgtca attaagtgga aagatggacc ctcattctat ctgcttggga aacagtcctt      180

attaatagca acactgacag aacctgaggt ttggagatgt actaatggct ttcagcctgt      240

gttggaaagc tcccaggagc ccatggagtt tcctgcaggc tgtgaacaat gggtctcccc      300

tgtttctctg gaggacagtg gggagctgtt tggatcctaa gatgaaagcc tacctggaag      360

agaacactga agtcaccagc agtggtagcc ttaccccgga aatccagtta cggcttttaa      420

cccccaggtg caagttttgg tgggaaaggg ctgacctgtg gccctacagt gatccctact      480

gggctattta ctggccagga ggccaggctc tgtctaggta tcttttggat aaccctgctg      540

ttgttagagg aaagtctgtc ttagatcttg ggagtggatg tggagctaca gccattgctg      600

ccaagatgag tggagcatca aagatcttgg ccaacgacat agaccccatt gcaggaatgg      660

cgattacact aaattgcaaa ttaaatggac tgaatccttt tcctgtttta actaaaaaca      720

ttttgaatac ccaacaaggt aagtttgatc tcattgttct tggagatatg ttttatgatg      780

aagaccttgc agacagtctt catctgtggc tgcagaacta cttttggacc catggaaccc      840

gagtactgat tggtgaccct gggaggcccc agttcagtgg acatagcatt cggcatcaac      900

tgtaccaact agtagaatac acacttccag agccaactca gcaagagaac aatggactga      960

ccacaagtgc tgtatgggat tttcatccct gatttgttaa agtgctttca agtatgaata     1020

tagttctgtt tgtgttaagt tctaaaaata tcctctgtag gaggtattca acagtttaaa     1080

gaatgcaatt cagtggcttg tggtggattg ggccttgaat actaccactt gggaggctga     1140

agtaggcgca tctcggtgac tttgaggaca gcttggtcta tagtgagttc aaggacagcc     1200

agagctatat agtaagaccc tgttccaaaa atagatagat agataataaa gtaaatttct     1260

tcattccttt gctgtgacac cttgaataac tgtatggttt attaaagtta gttatggtta     1320

tgttcccatt tcacatacca aggtgtcagg attttataac aaagcactct atcatataca     1380

attgcatatg tagaaggtat atttatatat gtatgtatgt atggatgtaa tatatataat     1440

ttgcttcagt attaataaaa tatctctgga aagataaaaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  1548


<210>  209
<211>  128
<212>  PRT
<213>  Mus musculus

<400>  209

Met Ser Gly Ala Ser Lys Ile Leu Ala Asn Asp Ile Asp Pro Ile Ala 
1               5                   10                  15      


Gly Met Ala Ile Thr Leu Asn Cys Lys Leu Asn Gly Leu Asn Pro Phe 
            20                  25                  30          


Pro Val Leu Thr Lys Asn Ile Leu Asn Thr Gln Gln Gly Lys Phe Asp 
        35                  40                  45              


Leu Ile Val Leu Gly Asp Met Phe Tyr Asp Glu Asp Leu Ala Asp Ser 
    50                  55                  60                  


Leu His Leu Trp Leu Gln Asn Tyr Phe Trp Thr His Gly Thr Arg Val 
65                  70                  75                  80  


Leu Ile Gly Asp Pro Gly Arg Pro Gln Phe Ser Gly His Ser Ile Arg 
                85                  90                  95      


His Gln Leu Tyr Gln Leu Val Glu Tyr Thr Leu Pro Glu Pro Thr Gln 
            100                 105                 110         


Gln Glu Asn Asn Gly Leu Thr Thr Ser Ala Val Trp Asp Phe His Pro 
        115                 120                 125             


<210>  210
<211>  2371
<212>  DNA
<213>  Mus musculus

<400>  210
gaggcggtgg caccgcgcgg gacggagtta aggtcttctt tatcggcagt gtacggcggc       60

ggccgagcgg aggagtagtc agtggctgcg gacgagccct cgggggtgcg agcgtgaccg      120

cggccaagcc cgcgcgtcgc cttctgcggc gagtagggcc tcgcggcgtc atcggcggcg      180

agtagccgct gcggcctggc cgaccatgtc ggacgcggct gaggagcagc ccatggagac      240

gacgggcgcc accgagaacg gacacgaggc cgcccccgaa ggcgaggccc cggtcgagcc      300

cagcgcggct gccgcggccc ccgcggcctc ggccgggtct gggggcggga ccacgaccgc      360

accgagcggg aaccagaacg gcgcggaggg cgaccagatc aacgccagca agaacgagga      420

ggacgcggga aaaatgttcg ttggtggtct gagctgggat accagcaaaa aagacttaaa      480

ggattatttt actaagtttg gagaggttgt tgactgtaca ataaaaatgg atcccaacac      540

tggacgatca agagggtttg ggtttattct cttcaaagat tcttctagtg tggaaaaggt      600

cttagatcag aaggagcaca ggctggatgg tcgtgtcatt gaccctaaaa aggctatggc      660

tatgaagaag gaccctgtga agaaaatctt tgtgggaggt ctaaaccctg aagccacaga      720

ggaaaagatc agagaatact tcggccagtt tggggagatt gaggccattg agcttccaat      780

agatcccaag ttgaacaaaa gacggggttt tgtttttatt acatttaaag aggaagatcc      840

tgtgaagaaa gttctggaga agaaatttca tactgtcagt ggaagcaagt gtgaaatcaa      900

ggttgcccag cccaaagagg tgtatcagca acagcagtat ggctctgggg gcagaggaaa      960

tcgcaatcga gggaaccgag gcagtggtgg aggtcagggt agtacaaatt acggaaagag     1020

ccagcgacgt ggtggtcatc agaataacta caagccatac tgagaggcag caggagcggc     1080

cgagtgacga ccgcacacgc tttgtttgga cgcggagtga acacaattat gtaccaaatt     1140

taacttggca aacttttatg gcctgtccca tgtgcatctt atttaaaatt tcccccagaa     1200

atcactctcc tgtttactat tccagagctc tagttgtagg cagcgtgtgg cgtctcagag     1260

gccagagcgg cactaggggg ctgattttat taccaggtta ccctgttcta gatcaggagg     1320

gtctatttcc tgttgccgct ctgcagcctg gacctgtgga ccctggttgt aaagagtaaa     1380

actgtatctt aggaaaccag tgtcaccttt ttcacctttt aattttatat tatttgtgtc     1440

atacatttcc agtaatggaa gtgttaattt tactgtactt tttggtacct tttgggaatc     1500

taatgtattg taaggtattt tacacgtgtc ctgattttgc cacgacctgg atattgaagc     1560

tatccaagct tttgaaataa aaatgaaaaa caaaaccccc aagcctgggt aaatgtggga     1620

tgctctgtga gaccttgccc agtgttggag atgccaggtc tcctgtagca aagcagaggt     1680

cctttagtta tcccatctga tctttttagc tgcccttttg tgcccattgt ctccatagca     1740

gagaccatct tgccatgtat tatatatatt ccatgttctt agtttcagtc aagtacaagt     1800

tgaaatgttg gggatctgct gatggaggtg gggccaagtc tggcttacct ggggggtgct     1860

tgatcctcag ggtttcacaa cttcttactt tttcttccat gtctggaaaa tgatcacaga     1920

tcgtttcttt ttccccccaa gacagggttt ctctgtagcc ctggttaggt tatcctggaa     1980

ctctgtagac caggctggcc ttgaactcag aaatccacct ggctctgcct cccaagtgct     2040

gggattaaag gcgtgcgcca ccacgcctgg cctaccctca gtttctaaga tgcttgggat     2100

agtttagaga ttggcttatg tctcatcatt tccctagcac agatggtccc tttgtaagcc     2160

cagtcaccac tcactgttct gtacacatag aaccctctaa gaaatgtatc aattccaaaa     2220

cgcagtaggg gtggctaaca agcaggaata ggaagggatc cttggtagct tgttttttgt     2280

ctgttgggat ctgagctttg tataacaacc actttggtgt atagtcattt ctagttcggt     2340

agttttctta aataaattga gggagacctt g                                    2371


<210>  211
<211>  1712
<212>  DNA
<213>  Mus musculus

<400>  211
cgaggcggtg gcaccgcgcg ggacggagtt aaggtcttct ttatcggcag tgtacggcgg       60

cggccgagcg gagcgatagt cagtggctgc ggacgagccc tcgggggtgc gagcgtgacc      120

gcggccaagc ccgcgcgtcg ccttctgcgg cgagtagggc ctcgcggcgt catcggcggc      180

gagtagccgc tgcggcctgg ccgaccatgt cggacgcggc tgaggagcag cccatggaga      240

cgacgggcgc caccgagaac ggacacgagg ccgcccccga aggcgaggcc ccggtcgagc      300

ccagcgcggc tgccgcggcc cccgcggcct cggccgggtc tgggggcggg aaccagaacg      360

gcgcggaggg cgaccagatc aacgccagca agaacgagga ggacgcggga aaaatgttcg      420

ttggtggtct gagctgggat accagcaaaa aagacttaaa ggattatttt actaagtttg      480

gagaggttgt tgactgtaca ataaaaatgg atcccaacac tggacgatca agagggtttg      540

ggtttattct cttcaaagat tcttctagtg tggaaaaggt cttagatcag aaggagcaca      600

ggctggatgg tcgtgtcatt gaccctaaaa aggctatggc tatgaagaag gaccctgtga      660

agaaaatctt tgtgggaggt ctaaaccctg aagccacaga ggaaaagatc agagaatact      720

tcggccagtt tggggagatt gaggccattg agcttccaat agatcccaag ttgaacaaaa      780

gacggggttt tgtttttatt acatttaaag aggaagatcc tgtgaagaaa gttctggaga      840

agaaatttca tactgtcagt ggaagcaagt gtgaaatcaa ggttgcccag cccaaagagg      900

tgtatcagca acagcagtat ggctctgggg gcagaggaaa tcgcaatcga gggaaccgag      960

gcagtggtgg aggtcagagt cagagttgga atcagggcta cggcaactac tggaaccagg     1020

gctacggcta ccagcagggc tacgggccgg gctatggcgg ctacgactac tcgccctatg     1080

gctattacgg ctacggcccc ggctacgact acagtcaggg tagtacaaat tacggaaaga     1140

gccagcgacg tggtggtcat cagaataact acaagccata ctgagaggca gcaggagcgg     1200

ccgagtgacg accgcacacg ctttgtttgg acgcggagtg aacacaatta tgtaccaaat     1260

ttaacttggc aaacttttat ggcctgtccc atgtgcatct tatttaaaat ttcccccaga     1320

aatcactctc ctgtttacta ttccagagct ctagttgtag gcagcgtgtg gcgtctcaga     1380

ggccagagcg gcactagggg gctgatttta ttaccaggtt accctgttct agatcaggag     1440

ggtctatttc ctgttgccgc tctgcagcct ggacctgtgg accctggttg taaagagtaa     1500

aactgtatct taggaaacca gtgtcacctt tttcaccttt taattttata ttatttgtgt     1560

catacatttc cagtaatgga agtgttaatt ttactgtact ttttggtacc ttttgggaat     1620

ctaatgtatt gtaaggtatt ttacacgtgt cctgattttg ccacgacctg gatattgaag     1680

ctatccaagc ttttgaaata aaaatgaaaa gc                                   1712


<210>  212
<211>  285
<212>  PRT
<213>  Mus musculus

<400>  212

Met Ser Asp Ala Ala Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Ala Pro Glu Gly Glu Ala Pro Val Glu Pro 
            20                  25                  30          


Ser Ala Ala Ala Ala Ala Pro Ala Ala Ser Ala Gly Ser Gly Gly Gly 
        35                  40                  45              


Thr Thr Thr Ala Pro Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln 
    50                  55                  60                  


Ile Asn Ala Ser Lys Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly 
65                  70                  75                  80  


Gly Leu Ser Trp Asp Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr 
                85                  90                  95      


Lys Phe Gly Glu Val Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr 
            100                 105                 110         


Gly Arg Ser Arg Gly Phe Gly Phe Ile Leu Phe Lys Asp Ser Ser Ser 
        115                 120                 125             


Val Glu Lys Val Leu Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val 
    130                 135                 140                 


Ile Asp Pro Lys Lys Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys 
145                 150                 155                 160 


Ile Phe Val Gly Gly Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg 
                165                 170                 175     


Glu Tyr Phe Gly Gln Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Ile 
            180                 185                 190         


Asp Pro Lys Leu Asn Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys 
        195                 200                 205             


Glu Glu Asp Pro Val Lys Lys Val Leu Glu Lys Lys Phe His Thr Val 
    210                 215                 220                 


Ser Gly Ser Lys Cys Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr 
225                 230                 235                 240 


Gln Gln Gln Gln Tyr Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly 
                245                 250                 255     


Asn Arg Gly Ser Gly Gly Gly Gln Gly Ser Thr Asn Tyr Gly Lys Ser 
            260                 265                 270         


Gln Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
        275                 280                 285 


<210>  213
<211>  325
<212>  PRT
<213>  Mus musculus

<400>  213

Met Ser Asp Ala Ala Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Ala Pro Glu Gly Glu Ala Pro Val Glu Pro 
            20                  25                  30          


Ser Ala Ala Ala Ala Ala Pro Ala Ala Ser Ala Gly Ser Gly Gly Gly 
        35                  40                  45              


Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys Asn Glu 
    50                  55                  60                  


Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp Thr Ser 
65                  70                  75                  80  


Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val Val Asp 
                85                  90                  95      


Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly Phe Gly 
            100                 105                 110         


Phe Ile Leu Phe Lys Asp Ser Ser Ser Val Glu Lys Val Leu Asp Gln 
        115                 120                 125             


Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys Ala Met 
    130                 135                 140                 


Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly Leu Asn 
145                 150                 155                 160 


Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gln Phe Gly 
                165                 170                 175     


Glu Ile Glu Ala Ile Glu Leu Pro Ile Asp Pro Lys Leu Asn Lys Arg 
            180                 185                 190         


Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Asp Pro Val Lys Lys 
        195                 200                 205             


Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys Glu Ile 
    210                 215                 220                 


Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr Gly Ser 
225                 230                 235                 240 


Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly Gly Gly 
                245                 250                 255     


Gln Ser Gln Ser Trp Asn Gln Gly Tyr Gly Asn Tyr Trp Asn Gln Gly 
            260                 265                 270         


Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro Gly Tyr Gly Gly Tyr Asp Tyr 
        275                 280                 285             


Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly Pro Gly Tyr Asp Tyr Ser Gln 
    290                 295                 300                 


Gly Ser Thr Asn Tyr Gly Lys Ser Gln Arg Arg Gly Gly His Gln Asn 
305                 310                 315                 320 


Asn Tyr Lys Pro Tyr 
                325 


<210>  214
<211>  1227
<212>  DNA
<213>  Mus musculus

<400>  214
atggctgaaa tgtaaagagc tttgctgtcg ccccggagct cacagtgtcg gtggcgtcgg       60

agaggactga ctcatccgct gtaaatggac gcgatactga actacaggcc ggagggcagc      120

gaggactact acgccttgct gggatgcgat gagctctcct cggttgagca aatcttggca      180

gaatttaaga ttagagctct ggagtgtcac cccgacaagc atcctgagaa ctccaaagct      240

gtggagactt ttcagaaatt gcagaaggcg aaggagattc tgtgcaatgc agagagtcga      300

gcccgctatg accattggcg gaggagccag atgtcaatgc cgttcgagca gtgggaagct      360

ttggccgact cagtgaaaac ttcgatgcat tgggctgtca gaagtaagaa ggacttgatg      420

ctggaaggaa gtggccagac gttcaccagc tcagttccaa acaaggaacg gagtgagcag      480

cgggaaacca agaaagggga cccagactca aacccagaga aaatgaagca aaaggaaccc      540

aagttcccag aggagggcat ctccccacaa aacccagact ctccaggtct ctcagacttg      600

aactgtggcc accttcgttt ccgctggtct ggtgacgctc cctcagaact cctgcggaag      660

ttcagaaact atgaaatctg aagcattgct gttctgggaa ggagggaggg caaggccttc      720

atctctgctg ccaaagcgaa tctttatgtc tttaaaatgt tgtgtttgtg agttactcag      780

aatggtcaag tcccccatcc tcccttgaag tcattcttac agtgtgcttt gtgttagttt      840

ttactgggga ttgaacccag gaccttccgt atgctctgta tcattgattc ttacctccta      900

catgttgttt aagtgagaaa aatggttgtt aagttgtagt ttatttcaat atttgagtca      960

attaaggctc ttagatacac ttgtttctaa gagtacattt agatactatg tagtttgtat     1020

ttctaagagt atacttagat actagttcct attatatgtt tttcctgtta atgttatttg     1080

tagatacttg ttaaaaatca ttctcttttg gtgtcttgtg atccctaccc atacaaaaat     1140

gtcttttgaa ttttggttta aaacaaaata tagacttact tgtctaaatt tcatagagtg     1200

aaataaataa tttcctcaaa aaaaaaa                                         1227


<210>  215
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  215

Met Asp Ala Ile Leu Asn Tyr Arg Pro Glu Gly Ser Glu Asp Tyr Tyr 
1               5                   10                  15      


Ala Leu Leu Gly Cys Asp Glu Leu Ser Ser Val Glu Gln Ile Leu Ala 
            20                  25                  30          


Glu Phe Lys Ile Arg Ala Leu Glu Cys His Pro Asp Lys His Pro Glu 
        35                  40                  45              


Asn Ser Lys Ala Val Glu Thr Phe Gln Lys Leu Gln Lys Ala Lys Glu 
    50                  55                  60                  


Ile Leu Cys Asn Ala Glu Ser Arg Ala Arg Tyr Asp His Trp Arg Arg 
65                  70                  75                  80  


Ser Gln Met Ser Met Pro Phe Glu Gln Trp Glu Ala Leu Ala Asp Ser 
                85                  90                  95      


Val Lys Thr Ser Met His Trp Ala Val Arg Ser Lys Lys Asp Leu Met 
            100                 105                 110         


Leu Glu Gly Ser Gly Gln Thr Phe Thr Ser Ser Val Pro Asn Lys Glu 
        115                 120                 125             


Arg Ser Glu Gln Arg Glu Thr Lys Lys Gly Asp Pro Asp Ser Asn Pro 
    130                 135                 140                 


Glu Lys Met Lys Gln Lys Glu Pro Lys Phe Pro Glu Glu Gly Ile Ser 
145                 150                 155                 160 


Pro Gln Asn Pro Asp Ser Pro Gly Leu Ser Asp Leu Asn Cys Gly His 
                165                 170                 175     


Leu Arg Phe Arg Trp Ser Gly Asp Ala Pro Ser Glu Leu Leu Arg Lys 
            180                 185                 190         


Phe Arg Asn Tyr Glu Ile 
        195             


<210>  216
<211>  1481
<212>  DNA
<213>  Mus musculus

<400>  216
ggcgcggaac ctgctgagct ggtggtggag gcgcgtggca gaggtgtgcg agagtgggag       60

ctgcaggatg gcaaaacata agcgaaaagg tctcgaaggg acaggaaagg agagtaaaag      120

gcagaaaata acaccggcag aggagacgcc gaggacatcg gaggctgggc cagacaagga      180

gacggccagt accctggtgc aggaggccag ccctgagttg tccccagagg agaggagagt      240

cttggaaagg aaactgaaga aggaacggaa gaaggaagag aagaaacggc tgagggaggc      300

gggcatcgct gctacacaga ctgccaaggt tcagacgctg ccagccaagc cctcggctgc      360

caccctggct ctggagtacc tccaagggtg ggctcagaag caggagagct ggcggttcca      420

gaagacaaga cagacgtggc tcctgctgca catgtatgat gaggacaagg ttcctgatga      480

gcactttcct accctgctgg actacctgga ggggctgcgg ggcagtgccc gggagctcac      540

agtccggaag gcagaggccc tgatgcagaa gctcgatgag gctgagcctg aggacagcgg      600

cgggtctccg gggaaggtgc agcgcctccg ccaggtgctg cagctgctct cctagtgggc      660

cccgagcact cactggctac ctcctcccag agctgtggga gcacacgggt ccccagcagg      720

tcatctggcc ggagtcctga gaagaacgct tcatcccctc cctatacgct gtaacagttt      780

ctagtgcctt gggagttgaa catggtctcc ctgaaacagc tctgaagtgc cactcccaca      840

cgagtggccc taaagtgact gtaaacagag tctacttttt ctaccaagaa tatcttagag      900

actggcccaa gctggctttc cccatcagct gggattccct ggtgtgtgtg tgtgtgtgtg      960

tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gggggactcc tacatattcg atctgggtgc     1020

cattgcagtg cagcctgaat gcgactcact ggtctgtagg gagagcctgt attgaggacc     1080

ctgggccagt gtggctgccc acgagctggt aaaagctgct gctccatgat ccctactcgt     1140

ttcaacaaca accccatgcc gttcctagtc tcagcagctg ggccgtgttc cttgtcattg     1200

cacctctctg ccagctcgtt ggaaacagaa ggactaagca tttgtatctg gattcccatc     1260

tgcagatggg agccatggcg tgtccccctt ctgcttcttg aactccccca cagccccctg     1320

caccagagtc acttatatac tcccaggtat ggaggtatat aaaggagctt tacagataaa     1380

tatatcccaa gaaatctatt ttaaagtgat tctgaataca aataattttc catgtattaa     1440

agataaagac aagtttgcgt aaaaaaaaaa aaaaaaaaaa a                         1481


<210>  217
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  217

Met Ala Lys His Lys Arg Lys Gly Leu Glu Gly Thr Gly Lys Glu Ser 
1               5                   10                  15      


Lys Arg Gln Lys Ile Thr Pro Ala Glu Glu Thr Pro Arg Thr Ser Glu 
            20                  25                  30          


Ala Gly Pro Asp Lys Glu Thr Ala Ser Thr Leu Val Gln Glu Ala Ser 
        35                  40                  45              


Pro Glu Leu Ser Pro Glu Glu Arg Arg Val Leu Glu Arg Lys Leu Lys 
    50                  55                  60                  


Lys Glu Arg Lys Lys Glu Glu Lys Lys Arg Leu Arg Glu Ala Gly Ile 
65                  70                  75                  80  


Ala Ala Thr Gln Thr Ala Lys Val Gln Thr Leu Pro Ala Lys Pro Ser 
                85                  90                  95      


Ala Ala Thr Leu Ala Leu Glu Tyr Leu Gln Gly Trp Ala Gln Lys Gln 
            100                 105                 110         


Glu Ser Trp Arg Phe Gln Lys Thr Arg Gln Thr Trp Leu Leu Leu His 
        115                 120                 125             


Met Tyr Asp Glu Asp Lys Val Pro Asp Glu His Phe Pro Thr Leu Leu 
    130                 135                 140                 


Asp Tyr Leu Glu Gly Leu Arg Gly Ser Ala Arg Glu Leu Thr Val Arg 
145                 150                 155                 160 


Lys Ala Glu Ala Leu Met Gln Lys Leu Asp Glu Ala Glu Pro Glu Asp 
                165                 170                 175     


Ser Gly Gly Ser Pro Gly Lys Val Gln Arg Leu Arg Gln Val Leu Gln 
            180                 185                 190         


Leu Leu Ser 
        195 


