                               SEQUENCE LISTING

<110> BOSTON MEDICAL CENTER CORPORATION
      LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120> DIAGNOSTICS FOR MEMBRANOUS NEPHROPATHY

<130> 701586-062701-PCT

<140> PCT/US2009/051110
<141> 2009-07-20

<150> 61/081,786
<151> 2008-07-18

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 1324
<212> PRT
<213> Homo sapiens

<400> 1
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Ser 
    1310                 1315                 1320             


Lys 
    


<210> 2
<211> 1463
<212> PRT
<213> Homo sapiens

<400> 2
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210> 3
<211> 5160
<212> DNA
<213> Homo sapiens

<400> 3
cccgagtgtc ggttcactgt ggagacagcg gtggcggagt gggtctccag ggctctgggc       60

tggcaaggcc cccggagggg gtggggcgcg gaggaggcta cggatccgct tccgcgcggc      120

ggggccgggt gcttgggacg cggctctggg ctcccgggat aaggggctcc cgggacaagg      180

ggctcccgga gagcccagtg gttagcgatg ctgctgtcgc cgtcgctgct gctgctgctg      240

ctgctggggg cgccgcgggg ctgcgccgag ggtgtggcgg cggcgcttac ccccgagcgg      300

ctcctggagt ggcaggataa aggaatattt gttatccaaa gtgagagtct caagaaatgc      360

attcaagcag gtaaatcggt tctgaccctg gagaactgca agcaagcaaa caagcacatg      420

ctgtggaaat gggtttcaaa ccatggcctc tttaacatag gaggcagtgg ttgcctgggc      480

ctgaatttct ccgccccaga gcagccatta agcttatatg aatgtgactc caccctcgtt      540

tccttacggt ggcgctgtaa caggaagatg atcacaggcc cgctgcagta ctctgtccag      600

gtggcgcatg acaacacagt ggtggcctca cggaagtata ttcataagtg gatttcttat      660

gggtcaggtg gtggagacat ttgtgaatat ctacacaaag atttgcatac aatcaaaggg      720

aacacccacg ggatgccgtg tatgtttccc ttccagtata accatcagtg gcatcatgaa      780

tgtacccgtg aaggtcggga agatgactta ctgtggtgtg ccacgacaag ccgttatgaa      840

agagatgaaa agtggggatt ttgccctgat cccacctctg cagaagtagg ttgtgatact      900

atttgggaga aggacctcaa ttcacacatt tgctaccagt tcaacctgct ttcatctctc      960

tcttggagtg aggcacattc ttcatgccag atgcaaggag gtacgctgtt aagtattaca     1020

gatgaaactg aagaaaattt cataagggag cacatgagca gtaaaacagt ggaggtgtgg     1080

atgggcctca atcagctgga tgaacacgct ggctggcagt ggtctgatgg aacgccgctc     1140

aactatctga attggagccc agaggtaaat tttgagccat ttgttgaaga tcactgtgga     1200

acatttagtt catttatgcc aagtgcctgg aggagtcggg attgtgagtc caccttgcca     1260

tatatatgta aaaaatatct aaaccacatt gatcatgaaa tagttgaaaa agatgcgtgg     1320

aaatattatg ctacccactg tgagcctggc tggaatccct acaatcgtaa ttgctacaaa     1380

cttcagaaag aagaaaagac ctggcatgag gctctgcgtt cttgtcaggc tgataacagt     1440

gcattaatag acataacctc attagcagag gtggagtttc ttgtaaccct ccttggagat     1500

gaaaatgcat cagaaacatg gattggtttg agcagcaata aaattccagt ttcctttgaa     1560

tggtctaatg actcttcagt catctttact aattggcaca cacttgagcc ccacattttt     1620

ccaaatagaa gccagctgtg tgtctcagca gagcagtctg agggacactg gaaagtcaaa     1680

aattgtgaag aaagactttt ttacatttgt aaaaaagcag gccatgtcct ctctgatgct     1740

gaatcaggat gtcaagaggg atgggagaga catggtggat tctgttacaa aattgacaca     1800

gtccttcgaa gctttgacca agcttccagc ggttattact gtcctcctgc acttgtaacc     1860

attacaaaca ggtttgaaca ggcttttatt accagtttga tcagtagtgt ggtaaaaatg     1920

aaggacagtt atttttggat agctcttcag gaccaaaatg atacgggaga atacacttgg     1980

aagccagtag ggcagaaacc cgagccggtg cagtacacac actggaacac acaccagccg     2040

cgctacagtg gtggctgtgt tgccatgcga ggaaggcatc cacttggtcg ctgggaagtg     2100

aagcactgtc ggcactttaa ggcaatgtcc ttgtgcaagc agccagttga aaatcaggaa     2160

aaagcagagt atgaagagag atggcccttt cacccctgct atttggactg ggagtcagag     2220

cctggtctgg ccagttgctt caaggtattt catagtgaaa aagttctgat gaaaagaaca     2280

tggagagaag ctgaagcatt ttgcgaagaa tttggagctc atcttgcaag ctttgcccat     2340

attgaggaag agaattttgt gaatgagctc ttacattcaa aatttaattg gacagaagaa     2400

aggcagttct ggattggatt taataaaaga aacccactga atgccggctc atgggagtgg     2460

tctgatagaa ctcctgttgt ctcttcgttt ttagacaaca cttattttgg agaagatgca     2520

agaaactgtg ctgtttataa ggcaaacaaa acattgctgc ccttacactg tggttccaaa     2580

cgtgaatgga tatgcaaaat cccaagagat gtgaaaccca agattccgtt ctggtaccag     2640

tacgatgtac cctggctctt ttatcaggat gcagaatacc tttttcatac ctttgcctca     2700

gaatggttga actttgagtt tgtctgtagc tggctgcaca gtgatcttct cacaattcat     2760

tctgcacatg agcaagaatt catccacagc aaaataaaag cgctatcaaa gtatggtgca     2820

agttggtgga ttggacttca agaagaaaga gccaatgatg aatttcgctg gagagatgga     2880

acaccagtga tataccagaa ctgggacaca ggaagagaaa gaactgtgaa taatcagagc     2940

cagagatgtg gctttatttc ttctataaca ggactctggg gtagtgaaga gtgttcagtt     3000

tctatgccta gtatctgtaa gcgaaaaaag gtttggctca tagagaaaaa gaaagataca     3060

ccaaaacaac atggaacgtg tcccaaagga tggctatatt ttaactataa gtgccttctg     3120

ctgaatatcc ccaaagaccc aagcagttgg aagaactgga cgcatgctca acatttctgt     3180

gctgaagaag gggggaccct ggtcgccatt gaaagtgagg tggagcaagc tttcattact     3240

atgaatcttt ttggccagac caccagtgtg tggataggtt tacaaaatga tgattatgaa     3300

acatggctaa atggaaagcc tgtggtatat tctaactggt ctccatttga tataataaat     3360

attccaagtc acaataccac tgaagttcag aaacacattc ctctctgtgc cttactctca     3420

agtaatccta attttcattt cactggaaaa tggtattttg aagactgtgg aaaggaaggc     3480

tatgggtttg tttgtgaaaa aatgcaagat acttctggac acggtgtaaa tacatctgat     3540

atgtatccaa tgcccaatac cttagaatat ggaaacagaa cttacaaaat aattaatgca     3600

aatatgactt ggtatgcagc aataaaaacc tgcctgatgc acaaagcaca actggtcagc     3660

atcacagacc agtatcacca gtccttcctc actgttgtcc tcaaccggct aggatatgcc     3720

cactggattg gactgttcac cacagataat ggtcttaatt ttgactggtc tgatggcacc     3780

aaatcttctt tcactttttg gaaagatgag gagtcctccc tccttggtga ctgcgttttt     3840

gccgacagca acggacgctg gcatagcaca gcctgcgagt catttctgca aggtgccatt     3900

tgtcatgtgc cacctgaaac aagacaatct gaacacccag agttgtgctc agaaacatct     3960

attccctgga taaaatttaa aagtaattgc tacagttttt ctacagtcct agacagtatg     4020

agttttgagg ctgctcatga attttgcaaa aaggaaggtt ctaatctttt aacaatcaag     4080

gatgaggctg aaaatgcatt tctcctagaa gagctgtttg cttttggttc ttctgtccag     4140

atggtttggt tgaatgctca atttgatggt aacagtaagt gatttgggta gaggagagga     4200

cataaataaa tacatggttg ttaaagctga tgataatggc atctgtgagc cagaaaactc     4260

tccttggata cgttttctga gaaaaaatag catgaagcct aaagccattt cttccaaaaa     4320

caacattgca acccttttct ttaccctttt gtcttttaaa ataatcccag aacaccaaaa     4380

ataaaaacaa acaataacat gtttatcttt acccttagca ggaagatgct tggctggaac     4440

tttgtgttca cagacttagt cattgcatac caaaaccata tttactggaa aatatcccag     4500

gtttctaaat gttataaaag cacaatagag ttatggaaat gtttccatga tgaactgtgc     4560

tgttaggatt cttatttgct actcataaaa accagagttt gtaataaaat ggaagcatgg     4620

tattcttttc tttatgtaat tgatggttat tgaaaggtac ttgtgaagaa aattatttta     4680

attggtatgg agagcttgtt acagtggtgt accaaggttg ggggtgagcc taccctttcg     4740

aggaggagta ttttaatcac caacattgtt tagaatttca agcagatggt gataataaaa     4800

agcagaccaa cttttagtta gctgtattgt tagttttaaa ttattttcag acaatacact     4860

attgcccaca catgggatgg actctcctac cgcccctacc cccttggtac atggctggct     4920

tggtattaaa gaaattcact gtaaaatctt tttagaaagt gagccatttt gtaatgatga     4980

agatgttagg acttcaaagg atttttcttt actcgattag ttttgtttat caaatgattt     5040

ctttaaatcg attatatata tatatggaat atttcaaaat tcaaactgtc acattaagaa     5100

acatgataac ctaaatgacc taaataagaa cactgtacct aaaataaaga ggcaacttta     5160


<210> 4
<211> 4876
<212> DNA
<213> Homo sapiens

<400> 4
cccgagtgtc ggttcactgt ggagacagcg gtggcggagt gggtctccag ggctctgggc       60

tggcaaggcc cccggagggg gtggggcgcg gaggaggcta cggatccgct tccgcgcggc      120

ggggccgggt gcttgggacg cggctctggg ctcccgggat aaggggctcc cgggacaagg      180

ggctcccgga gagcccagtg gttagcgatg ctgctgtcgc cgtcgctgct gctgctgctg      240

ctgctggggg cgccgcgggg ctgcgccgag ggtgtggcgg cggcgcttac ccccgagcgg      300

ctcctggagt ggcaggataa aggaatattt gttatccaaa gtgagagtct caagaaatgc      360

attcaagcag gtaaatcggt tctgaccctg gagaactgca agcaagcaaa caagcacatg      420

ctgtggaaat gggtttcaaa ccatggcctc tttaacatag gaggcagtgg ttgcctgggc      480

ctgaatttct ccgccccaga gcagccatta agcttatatg aatgtgactc caccctcgtt      540

tccttacggt ggcgctgtaa caggaagatg atcacaggcc cgctgcagta ctctgtccag      600

gtggcgcatg acaacacagt ggtggcctca cggaagtata ttcataagtg gatttcttat      660

gggtcaggtg gtggagacat ttgtgaatat ctacacaaag atttgcatac aatcaaaggg      720

aacacccacg ggatgccgtg tatgtttccc ttccagtata accatcagtg gcatcatgaa      780

tgtacccgtg aaggtcggga agatgactta ctgtggtgtg ccacgacaag ccgttatgaa      840

agagatgaaa agtggggatt ttgccctgat cccacctctg cagaagtagg ttgtgatact      900

atttgggaga aggacctcaa ttcacacatt tgctaccagt tcaacctgct ttcatctctc      960

tcttggagtg aggcacattc ttcatgccag atgcaaggag gtacgctgtt aagtattaca     1020

gatgaaactg aagaaaattt cataagggag cacatgagca gtaaaacagt ggaggtgtgg     1080

atgggcctca atcagctgga tgaacacgct ggctggcagt ggtctgatgg aacgccgctc     1140

aactatctga attggagccc agaggtaaat tttgagccat ttgttgaaga tcactgtgga     1200

acatttagtt catttatgcc aagtgcctgg aggagtcggg attgtgagtc caccttgcca     1260

tatatatgta aaaaatatct aaaccacatt gatcatgaaa tagttgaaaa agatgcgtgg     1320

aaatattatg ctacccactg tgagcctggc tggaatccct acaatcgtaa ttgctacaaa     1380

cttcagaaag aagaaaagac ctggcatgag gctctgcgtt cttgtcaggc tgataacagt     1440

gcattaatag acataacctc attagcagag gtggagtttc ttgtaaccct ccttggagat     1500

gaaaatgcat cagaaacatg gattggtttg agcagcaata aaattccagt ttcctttgaa     1560

tggtctaatg actcttcagt catctttact aattggcaca cacttgagcc ccacattttt     1620

ccaaatagaa gccagctgtg tgtctcagca gagcagtctg agggacactg gaaagtcaaa     1680

aattgtgaag aaagactttt ttacatttgt aaaaaagcag gccatgtcct ctctgatgct     1740

gaatcaggat gtcaagaggg atgggagaga catggtggat tctgttacaa aattgacaca     1800

gtccttcgaa gctttgacca agcttccagc ggttattact gtcctcctgc acttgtaacc     1860

attacaaaca ggtttgaaca ggcttttatt accagtttga tcagtagtgt ggtaaaaatg     1920

aaggacagtt atttttggat agctcttcag gaccaaaatg atacgggaga atacacttgg     1980

aagccagtag ggcagaaacc cgagccggtg cagtacacac actggaacac acaccagccg     2040

cgctacagtg gtggctgtgt tgccatgcga ggaaggcatc cacttggtcg ctgggaagtg     2100

aagcactgtc ggcactttaa ggcaatgtcc ttgtgcaagc agccagttga aaatcaggaa     2160

aaagcagagt atgaagagag atggcccttt cacccctgct atttggactg ggagtcagag     2220

cctggtctgg ccagttgctt caaggtattt catagtgaaa aagttctgat gaaaagaaca     2280

tggagagaag ctgaagcatt ttgcgaagaa tttggagctc atcttgcaag ctttgcccat     2340

attgaggaag agaattttgt gaatgagctc ttacattcaa aatttaattg gacagaagaa     2400

aggcagttct ggattggatt taataaaaga aacccactga atgccggctc atgggagtgg     2460

tctgatagaa ctcctgttgt ctcttcgttt ttagacaaca cttattttgg agaagatgca     2520

agaaactgtg ctgtttataa ggcaaacaaa acattgctgc ccttacactg tggttccaaa     2580

cgtgaatgga tatgcaaaat cccaagagat gtgaaaccca agattccgtt ctggtaccag     2640

tacgatgtac cctggctctt ttatcaggat gcagaatacc tttttcatac ctttgcctca     2700

gaatggttga actttgagtt tgtctgtagc tggctgcaca gtgatcttct cacaattcat     2760

tctgcacatg agcaagaatt catccacagc aaaataaaag cgctatcaaa gtatggtgca     2820

agttggtgga ttggacttca agaagaaaga gccaatgatg aatttcgctg gagagatgga     2880

acaccagtga tataccagaa ctgggacaca ggaagagaaa gaactgtgaa taatcagagc     2940

cagagatgtg gctttatttc ttctataaca ggactctggg gtagtgaaga gtgttcagtt     3000

tctatgccta gtatctgtaa gcgaaaaaag gtttggctca tagagaaaaa gaaagataca     3060

ccaaaacaac atggaacgtg tcccaaagga tggctatatt ttaactataa gtgccttctg     3120

ctgaatatcc ccaaagaccc aagcagttgg aagaactgga cgcatgctca acatttctgt     3180

gctgaagaag gggggaccct ggtcgccatt gaaagtgagg tggagcaagc tttcattact     3240

atgaatcttt ttggccagac caccagtgtg tggataggtt tacaaaatga tgattatgaa     3300

acatggctaa atggaaagcc tgtggtatat tctaactggt ctccatttga tataataaat     3360

attccaagtc acaataccac tgaagttcag aaacacattc ctctctgtgc cttactctca     3420

agtaatccta attttcattt cactggaaaa tggtattttg aagactgtgg aaaggaaggc     3480

tatgggtttg tttgtgaaaa aatgcaagat acttctggac acggtgtaaa tacatctgat     3540

atgtatccaa tgcccaatac cttagaatat ggaaacagaa cttacaaaat aattaatgca     3600

aatatgactt ggtatgcagc aataaaaacc tgcctgatgc acaaagcaca actggtcagc     3660

atcacagacc agtatcacca gtccttcctc actgttgtcc tcaaccggct aggatatgcc     3720

cactggattg gactgttcac cacagataat ggtcttaatt ttgactggtc tgatggcacc     3780

aaatcttctt tcactttttg gaaagatgag gagtcctccc tccttggtga ctgcgttttt     3840

gccgacagca acggacgctg gcatagcaca gcctgcgagt catttctgca aggtgccatt     3900

tgtcatgtgc cacctgaaac aagacaatct gaacacccag agttgtgctc agaaacatct     3960

attccctgga taaaatttaa aagtaattgc tacagttttt ctacagtcct agacagtatg     4020

agttttgagg ctgctcatga attttgcaaa aaggaaggtt ctaatctttt aacaatcaag     4080

gatgaggctg aaaatgcatt tctcctagaa gagctgtttg cttttggttc ttctgtccag     4140

atggtttggt tgaatgctca atttgatggt aacaatgaaa ccataaagtg gtttgatgga     4200

actcccacag accagtcaaa ctggggcatt cggaagccag acacagacta cttcaagccc     4260

catcattgtg ttgccttgag gatccctgaa ggattatggc agctatcccc gtgtcaagaa     4320

aaaaaaggct ttatatgtaa aatggaggca gatattcaca ctgcagaggc gctgccagaa     4380

aaaggaccaa gtcacagcat cattcctctt gcggttgtac tgacactgat agtcattgtg     4440

gccatttgca cactttcctt ctgcatatac aagcataacg gtggcttctt caggagactt     4500

gcagggtttc ggaatcctta ctatcctgca accaacttta gtacagtata tttagaagaa     4560

aatattctca tttctgatct tgagaagagt gaccaataat aatgaggtca gagaatgcca     4620

cagacaccag ggtaagtaaa gaagactaaa caggagtctc atctgtcttt ccctttacag     4680

cacagatgcc attagaatgt gaattgggtc actattttaa ttattcttga agtgattact     4740

ggttttgaat cttaaccaaa tcagatgggt tttgatttat tcatttccct aaactgtgat     4800

ccattcttaa aaggggtaaa ttatgcattg gttatttttc agaaagacaa gaactattaa     4860

aagaaactcc ctattg                                                     4876


<210> 5
<211> 1395
<212> PRT
<213> Homo sapiens

<400> 5
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Asp Glu Thr 
    1310                 1315                 1320             


Ile Lys  Trp Phe Asp Gly Thr  Pro Thr Asp Gln Ser  Asn Trp Gly 
    1325                 1330                 1335             


Ile Arg  Lys Pro Asp Thr Asp  Tyr Phe Lys Pro His  His Cys Val 
    1340                 1345                 1350             


Ala Leu  Arg Ile Pro Glu Gly  Leu Trp Gln Leu Ser  Pro Cys Gln 
    1355                 1360                 1365             


Glu Lys  Lys Gly Phe Ile Cys  Lys Met Glu Ala Asp  Ile His Thr 
    1370                 1375                 1380             


Ala Glu  Ala Leu Pro Glu Lys  Gly Pro Ser His Ser  
    1385                 1390                 1395 


<210> 6
<211> 6
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      oligonucleotide"  

<400> 6
aauaaa                                                                   6


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      6xHis tag"  

<400> 7
His His His His His His 
1               5       


