
                                SEQUENCE LISTING

<110> Trinity Therapeutics, Inc.

<120> METHODS FOR TREATING IMMUNE-MEDIATED
  DENGUE FEVER INFECTIONS AND ANTIBODY-DEPENDENT ENHANCEMENT
  OF DENGUE FEVER INFECTIONS, INCLUDING DENGUE HEMORRHAGIC
  FEVER AND DENGUE SHOCK SYNDROME
  

<130> 20160/0013WO1

<150> 61/081,943          
<151> 2008-07-18  

<160> 56

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=absent any amino acid

<220> 
<221> VARIANT        
<222> 4
<223> Xaa=Phe, Tyr, Trp, 5-Hydoxytryptophan (5-HTP), or
      Arg

<220> 
<221> VARIANT        
<222> 6
<223> Xaa=any amino acid

<220> 
<221> VARIANT        
<222> 7
<223> Xaa=Gly or Ala


<220> 
<221> VARIANT        
<222> 8
<223> Xaa=Glu or Ala


<220> 
<221> VARIANT        
<222> 13
<223> Xaa=absent or any amino acid

<400> 1
Xaa Cys Ala Xaa His Xaa Xaa Xaa Leu Val Trp Cys Xaa
 1               5                  10              


<210> 2
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 2
Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10              


<210> 3
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 3
Asp Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10              


<210> 4
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 4
Asp Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10              


<210> 5
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 5
Arg Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10              


<210> 6
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 6
Arg Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10              


<210> 7
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 7
Arg Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10              


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 3
<223> Xaa=Phe, Tyr, Trp, or Arg

<400> 8
Cys Ala Xaa His Leu Gly Glu Leu Val Trp Cys
 1               5                  10      


<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 9
Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10          


<210> 10
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 10
Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10          


<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 11
Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10          


<210> 12
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<220> 
<221> VARIANT        
<222> 6
<223> Xaa=Trp, Tyr, Phe, or Arg

<400> 12
Xaa Pro Pro Cys Ala Xaa His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15  


<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 13
Xaa Pro Pro Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15  


<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 14
Ala Pro Pro Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15  


<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 15
Xaa Pro Pro Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15  


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 16
Ala Pro Pro Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15  


<210> 17
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 17
Xaa Pro Pro Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15  


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 18
Ala Pro Pro Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15  


<210> 19
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 19
Xaa Pro Pro Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 20
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 20
Ala Pro Pro Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 21
Xaa Pro Pro Asp Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 22
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 22
Ala Pro Pro Asp Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 23
Xaa Pro Pro Asp Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 24
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 24
Ala Pro Pro Asp Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 25
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 25
Xaa Pro Pro Arg Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 26
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 26
Ala Pro Pro Arg Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 27
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 27
Xaa Pro Pro Arg Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 28
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 28
Ala Pro Pro Arg Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 29
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1
<223> Xaa=any amino acid

<400> 29
Xaa Pro Pro Arg Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 30
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 30
Ala Pro Pro Arg Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 15
<223> Xaa=any amino acid

<400> 31
Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15  


<210> 32
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 32
Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15  


<210> 33
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT       
<222> 15
<223> Xaa=any amino acid

<400> 33
Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15  


<210> 34
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 34
Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15  


<210> 35
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 15
<223> Xaa=any amino acid

<400> 35
Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15  


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 36
Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15  


<210> 37
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 16
<223> Xaa=any amino acid

<400> 37
Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15      


<210> 38
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 38
Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15      


<210> 39
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 16
<223> Xaa=any amino acid

<400> 39
Asp Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15      


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 40
Asp Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15      


<210> 41
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 16
<223> Xaa=any amino acid

<400> 41
Asp Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15      


<210> 42
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 42
Asp Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15      


<210> 43
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 16
<223> Xaa=any amino acid

<400> 43
Arg Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15      


<210> 44
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 44
Arg Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15      


<210> 45
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 16
<223> Xaa=any amino acid

<400> 45
Arg Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15      


<210> 46
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 46
Arg Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15      


<210> 47
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 16
<223> Xaa=any amino acid

<400> 47
Arg Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Xaa
 1               5                  10                  15      


<210> 48
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 48
Arg Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr Pro Pro Ala
 1               5                  10                  15      


<210> 49
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 4
<223> Xaa=absent or any amino acid

<220> 
<221> VARIANT        
<222> 7
<223> Xaa=Phe, Tyr, 5-HTP, Trp, or Arg

<220> 
<221> VARIANT        
<222> 9
<223> Xaa=any amino acid

<220> 
<221> VARIANT        
<222> 10
<223> Xaa=Gly or Ala


<220> 
<221> VARIANT        
<222> 11
<223> Xaa=Glu or Ala


<220> 
<221> VARIANT        
<222> 16
<223> Xaa=absent or any amino ac

<400> 49
Trp Glu Ala Xaa Cys Ala Xaa His Xaa Xaa Xaa Leu Val Trp Cys Xaa
 1               5                  10                  15      
Lys Val Glu Glu
            20  


<210> 50
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 7
<223> Xaa=Arg, Trp, 5-HTP, Tyr, or Phe

<400> 50
Trp Glu Ala Asp Cys Ala Xaa His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      
Lys Val Glu Glu
            20  


<210> 51
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 51
Trp Glu Ala Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr
 1               5                  10                  15      
Lys Val Glu Glu
            20  


<210> 52
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1,2,3,4,5,6,18,19,20,21,22
<223> Xaa=absent or any amino acid

<220> 
<221> VARIANT        
<222> 9
<223> Xaa=Phe, Tyr, 5-HTP, Trp, or Arg

<220> 
<221> VARIANT        
<222> 11
<223> Xaa=any amino acid

<220> 
<221> VARIANT        
<222> 12
<223> Xaa=Gly or Ala


<220> 
<221> VARIANT        
<222> 13
<223> Xaa=Glu or Ala

<400> 52
Xaa Xaa Xaa Xaa Xaa Xaa Cys Ala Xaa His Xaa Xaa Xaa Leu Val Trp
 1               5                  10                  15      
Cys Xaa Xaa Xaa Xaa Xaa
            20          


<210> 53
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> 1,2,3,4,5,18,19,20,21,22
<223> Xaa=absent or any amino acid

<220> 
<221> VARIANT        
<222> 8
<223> Xaa=Trp, Tyr, Phe, 5-Hydroxytrphophan (5-HTP),
      5-hydroxytryptamine (5-HT), or another amino acid
      derivative

<400> 53
Xaa Xaa Xaa Xaa Xaa Cys Ala Xaa His Leu Gly Glu Leu Val Trp Cys
 1               5                  10                  15      
Thr Xaa Xaa Xaa Xaa Xaa
            20          


<210> 54
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 54
Ala Ala Ala Ala Ala Asp Cys Ala Arg His Leu Gly Glu Leu Val Trp
 1               5                  10                  15      
Cys Ala Ala Ala Ala Ala
            20          


<210> 55
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 55
Ala Ala Arg Cys Ala Arg His Leu Gly Glu Leu Val Trp Cys Thr Ala
 1               5                  10                  15      
Ala
    


<210> 56
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 56
Ala Ala Ala Asp Cys Ala Phe Trp His Leu Gly Glu Leu Val Trp Cys
 1               5                  10                  15      
Thr Ala Ala
            

