                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
       Lori, Sussel
 
<120>  TM4SF4 AND MODULATORS THEREOF AND METHODS FOR THEIR USE

<130>  IR2392 (C035795/0234221)

<150>  61/135,009
<151>  2008-07-15

<160>  66    

<170>  PatentIn version 3.3

<210>  1
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Cys Thr Gly Gly Cys Ala Arg Cys Leu Gly Gly Thr Leu Ile Pro 
1               5                   10                  15      


Leu Ala Phe Phe Gly Phe Leu Ala Asn Ile Leu Leu Phe Phe Pro Gly 
            20                  25                  30          


Gly Lys Val Ile Asp Asp Asn Asp His Leu Ser Gln Glu Ile Trp Phe 
        35                  40                  45              


Phe Gly Gly Ile Leu Gly Ser Gly Val Leu Met Ile Phe Pro Ala Leu 
    50                  55                  60                  


Val Phe Leu Gly Leu Lys Asn Asn Asp Cys Cys Gly Cys Cys Gly Asn 
65                  70                  75                  80  


Glu Gly Cys Gly Lys Arg Phe Ala Met Phe Thr Ser Thr Ile Phe Ala 
                85                  90                  95      


Val Val Gly Phe Leu Gly Ala Gly Tyr Ser Phe Ile Ile Ser Ala Ile 
            100                 105                 110         


Ser Ile Asn Lys Gly Pro Lys Cys Leu Met Ala Asn Ser Thr Trp Gly 
        115                 120                 125             


Tyr Pro Phe His Asp Gly Asp Tyr Leu Asn Asp Glu Ala Leu Trp Asn 
    130                 135                 140                 


Lys Cys Arg Glu Pro Leu Asn Val Val Pro Trp Asn Leu Thr Leu Phe 
145                 150                 155                 160 


Ser Ile Leu Leu Val Val Gly Gly Ile Gln Met Val Leu Cys Ala Ile 
                165                 170                 175     


Gln Val Val Asn Gly Leu Leu Gly Thr Leu Cys Gly Asp Cys Gln Cys 
            180                 185                 190         


Cys Gly Cys Cys Gly Gly Asp Gly Pro Val 
        195                 200         


<210>  2
<211>  1428
<212>  DNA
<213>  Homo sapiens

<400>  2
cttcaggtca gggagaatgt ataaatgtcc attgccatcg aggttctgct atttttgaga     60

agctgaagca actccaagga cacagttcac agaaatttgg ttctcagccc caaaatactg    120

attgaattgg agacaattac aaggactctc tggccaaaaa cccttgaaga ggccccgtga    180

aggaggcagt gaggagcttt tgattgctga cctgtgtcgt accaccccag aatgtgcact    240

gggggctgtg ccagatgcct gggggggacc ctcattcccc ttgctttttt tggcttcctg    300

gctaacatcc tgttattttt tcctggagga aaagtgatag atgacaacga ccacctttcc    360

caagagatct ggtttttcgg aggaatatta ggaagcggtg tcttgatgat cttccctgcg    420

ctggtgttct tgggcctgaa gaacaatgac tgctgtgggt gctgcggcaa cgagggctgt    480

gggaagcgat ttgcgatgtt cacctccacg atatttgctg tggttggatt cttgggagct    540

ggatactcgt ttatcatctc agccatttca atcaacaagg gtcctaaatg cctcatggcc    600

aatagtacat ggggctaccc cttccacgac ggggattatc tcaatgatga ggccttatgg    660

aacaagtgcc gagagcctct caatgtggtt ccctggaatc tgaccctctt ctccatcctg    720

ctggtcgtag gaggaatcca gatggttctc tgcgccatcc aggtggtcaa tggcctcctg    780

gggaccctct gtggggactg ccagtgttgt ggctgctgtg ggggagatgg acccgtttaa    840

acctccgaga tgagctgctc agactctaca gcatgacgac tacaatttct tttcataaaa    900

cttcttctct tcttggaatt attaattcct atctgcttcc tagctgataa agcttagaaa    960

aggcagttat tccttctttc caaccagctt tgctcgagtt agaattttgt tattttcaaa   1020

taaaaaatag tttggccact taacaaattt gatttataaa tctttcaaat tagttccttt   1080

ttagaattta ccaacaggtt caaagcatac ttttcatgat ttttttatta caaatgtaaa   1140

atgtataaag tcacatgtac tgccatacta cttctttgta tataaagatg tttatatctt   1200

tggaagtttt acataaatca aaggaagaaa gcacatttaa aatgagaaac taagaccaat   1260

ttctgttttt aagaggaaaa agaatgattg atgtatccta agtattgtta tttgttgtct   1320

ttttttgctg ccttgcttga gttgcttgtg actgatcttt tgaggctgtc atcatggcta   1380

gggttctttt atgtatgtta aattaaaacc tgaattcaga ggtaacgt                1428


<210>  3
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; cloning primer_forward

<400>  3
atcatgtgct ctggaaattt cgcc                                            24


<210>  4
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; cloning primer_reverse

<400>  4
ttactttatt ccttgcagca gccg                                            24


<210>  5
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct; MO Tm4sf4-atg

<400>  5
aatttccaga gcacatgatt gagtc                                           25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; MO Tm4sf4-spl

<400>  6
gttattgttt ttctcaccgc aaatc                                           25


<210>  7
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; MOnk-5UTR

<400>  7
tggagcattt gatgcagtca agttg                                           25


<210>  8
<211>  1576
<212>  DNA
<213>  Danio rerio

<400>  8
gtgcactcct tactttcatt tggagatatt tcattaactg tgcggtgtct caacgcaagc     60

tgcaccactt accctcttcc gtcagccgcc agaggattgt caaactggtg cagcaacttg    120

actgcatcaa atgctccaga acatgtcgtt gaccaacaca aagacgggct tttcagtaaa    180

ggacattttg gacctccctg atactaacga tgaagaagga tctatcaccg gcaccgagga    240

agatacggag ggttctgagg cgactaaaac gcctggagtg ttagtgcaaa gtcctttaga    300

gaatgttcaa aacctgcctt taaagaatcc attttatgat aatagcgaca atccttatac    360

tagatggctc gcaaccacgg acagcatcca atactcatta cacggcctgt ccgcgaactc    420

tcaagacacg tccgcaaaat ctccggaacc ttcagctgat gaatcgccgg acaatgacaa    480

ggaaacttca agcaacggca gcgactctgg taagaagcgc aaaaggaggg tgctcttttc    540

caaggcacaa acttacgaac tcgagcgccg gtttaggcaa cagagatatc tgtcagcccc    600

ggagagggag catctcgcca gtttgattcg cctgactcca acccaagtga aaatctggtt    660

ccagaaccac cgatataaaa tgaagagagc ccgggcggag aaaggtatgg aagtgaccca    720

tctcccttct cctaggcggg tggccgtgcc tgtgttagtc agagacggca aaccttgcca    780

tacgctaaaa gctcaggact tggcagctac ttttcaggct ggaattccgt tctctgcgta    840

tagcgcccag tctctccagc acatgcaata taacgcgcat tacagcgccg ccactacacc    900

acagttccca acagcacatc acttggtgca aacgcaacag tggacttggt gaacaaatac    960

tgacttgcaa tgcagggttg cattttaaag accgtggtag ggagctttcc aaacaaaaat   1020

acaagacttt ttatttttgc agcttgaccc tttctcacca atttattttg gggattgacg   1080

tgtgcgccat gtttacatgt tttcgttaag aaaaccgggt caagcctctc cccaaattta   1140

agaatgttaa agctcttgtg aaattttgta aagtatgttt gtgtgttgta gaaatgtttt   1200

tcttttgtcc ttcgtgttat acgcacgtgc aaaaccactt tatgattata gaaaatttta   1260

tttctttctt ttacaatgga ccgaatatat ttatggccat gaataaacac tggcaatcct   1320

tagcttattt cattggtttg ttttatatgt aaatattttg tgataactgt ttgcaatatt   1380

atgtttgacc gtccagtaag ctatatccta aatatatgcc atatttaggg aagatggaac   1440

atcattgtcg acaatatccc ttctgttaat ttcagcaggt aacaacgcgc gctggcgagg   1500

gaagtctaca gttcttttta ttaaaacttt taataaaatt atgtgtttca gaaaaaaaaa   1560

aaaaaaaaaa aaaaaa                                                   1576


<210>  9
<211>  269
<212>  PRT
<213>  Danio rerio

<400>  9

Met Ser Leu Thr Asn Thr Lys Thr Gly Phe Ser Val Lys Asp Ile Leu 
1               5                   10                  15      


Asp Leu Pro Asp Thr Asn Asp Glu Glu Gly Ser Ile Thr Gly Thr Glu 
            20                  25                  30          


Glu Asp Thr Glu Gly Ser Glu Ala Thr Lys Thr Pro Gly Val Leu Val 
        35                  40                  45              


Gln Ser Pro Leu Glu Asn Val Gln Asn Leu Pro Leu Lys Asn Pro Phe 
    50                  55                  60                  


Tyr Asp Asn Ser Asp Asn Pro Tyr Thr Arg Trp Leu Ala Thr Thr Asp 
65                  70                  75                  80  


Ser Ile Gln Tyr Ser Leu His Gly Leu Ser Ala Asn Ser Gln Asp Thr 
                85                  90                  95      


Ser Ala Lys Ser Pro Glu Pro Ser Ala Asp Glu Ser Pro Asp Asn Asp 
            100                 105                 110         


Lys Glu Thr Ser Ser Asn Gly Ser Asp Ser Gly Lys Lys Arg Lys Arg 
        115                 120                 125             


Arg Val Leu Phe Ser Lys Ala Gln Thr Tyr Glu Leu Glu Arg Arg Phe 
    130                 135                 140                 


Arg Gln Gln Arg Tyr Leu Ser Ala Pro Glu Arg Glu His Leu Ala Ser 
145                 150                 155                 160 


Leu Ile Arg Leu Thr Pro Thr Gln Val Lys Ile Trp Phe Gln Asn His 
                165                 170                 175     


Arg Tyr Lys Met Lys Arg Ala Arg Ala Glu Lys Gly Met Glu Val Thr 
            180                 185                 190         


His Leu Pro Ser Pro Arg Arg Val Ala Val Pro Val Leu Val Arg Asp 
        195                 200                 205             


Gly Lys Pro Cys His Thr Leu Lys Ala Gln Asp Leu Ala Ala Thr Phe 
    210                 215                 220                 


Gln Ala Gly Ile Pro Phe Ser Ala Tyr Ser Ala Gln Ser Leu Gln His 
225                 230                 235                 240 


Met Gln Tyr Asn Ala His Tyr Ser Ala Ala Thr Thr Pro Gln Phe Pro 
                245                 250                 255     


Thr Ala His His Leu Val Gln Thr Gln Gln Trp Thr Trp 
            260                 265                 


<210>  10
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct; siRNA hTm4 idt4, sense

<400>  10
gatccccggc tgtcatcatg gctagggttt tcaagagaaa ccctagccat gatgacagcc     60

tttttggaaa                                                            70


<210>  11
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA hTm4 idt4, antisense

<400>  11
agcttttcca aaaaggctgt catcatggct agggtttctc ttgaaaaccc tagccatgat     60

gacagccggg                                                            70


<210>  12
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA hTm4 idt5_sense

<400>  12
gatccccgag aaactaagac caatttctgt ttcaagagaa cagaaattgg tcttagtttc     60

tctttttgga aa                                                         72


<210>  13
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA hTm4 idt5_antisense

<400>  13
agcttttcca aaaagagaaa ctaagaccaa tttctgttct cttgaaacag aaattggtct     60

tagtttctcg gg                                                         72


<210>  14
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA hTm4 dh6_sense

<400>  14
gatccccgaa aagtgataga tgacaattca agagattgtc atctatcact tttctttttg     60

gaaa                                                                  64


<210>  15
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA hTm4 dh6_antisense

<400>  15
agcttttcca aaaagaaaag tgatagatga caatctcttg aattgtcatc tatcactttt     60

cggg                                                                  64


<210>  16
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA hTm4 ob899_sense

<400>  16
gatccccagc tggatactcg tttatcattt caagagaatg ataaacgagt atccagcttt     60

tttggaaa                                                              68


<210>  17
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA hTm4 ob899_antisense

<400>  17
agcttttcca aaaaagctgg atactcgttt atcattctct tgaaatgata aacgagtatc     60

cagctggg                                                              68


<210>  18
<211>  2026
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (2019)..(2019)
<223>  n is a, c, g, or t

<400>  18
cggagccgga gctgacggca ccttggcacc tctcctggag ttacaaactg aggccgcgcg     60

gcgctgggcg cgcaggccgc cagtcacagc ctacatttct gcgtgctttc cgagaagaga    120

gaggcaccgg gtgggcttta tttttttttc ccctttccct tttcccccca cagtgtcctc    180

tcattttaaa taataattat cccaataatt aaaacccatc ccccatccct cccccccatt    240

cctttcctta aacccccctc ccccgcccgc tggggctggg gagagccacg aattgaccaa    300

gtgaggctac aactttgtgg cataaattgc ggggtccgga accatgtcgc tgaccaacac    360

aaagacgggg ttttcagtca aggacatctt ggaccttccg gacaccaacg atgaagacgg    420

ctcggtggcc gaagggccag aggaggagag cgaagggccg gagcccgcca agagggccgg    480

gccgctgggg cagggcgccc tggacgctgt gcagagcctg ccccttaaga gccctttcta    540

cgacagcagc gacaacccct acactcgctg gctggccagc accgagggcc tccaatactc    600

cctgcacggg ctggcggcca gcgctccccc ccaagactcg agctccaagt ccccagagcc    660

ctcggctgac gagtcaccgg acaatgacaa ggagacccag ggcggcgggg gggacgcagg    720

caagaagcgg aagcgccgag tgctcttctc caaagcgcag acctacgagc tggagcggcg    780

cttccggcag cagcggtacc tgtcggcgcc cgagcgcgag cacctggcca gcctcatccg    840

tctcacgccg acacaggtca agatctggtt ccagaaccat cgctacaaga tgaaacgtgc    900

ccgggcggag aaaggtatgg aggtgacgcc tctgccctcg ccgcgccgtg tggcagtgcc    960

ggtcttggtc agggacggca aaccgtgcca cgcgctcaaa gcccaggacc tggcagccgc   1020

caccttccag gcaggcatcc ccttttccgc ctacagcgcg cagtcgctgc agcacatgca   1080

gtacaacgcc cagtacagct cggccagcac cccccagtac ccgacagcac accccctggt   1140

ccaggcccag cagtggactt ggtgagcgcc gcccctccaa gactggaggc cttaggccct   1200

ggccccaccc cagcggcgcc ggtggcgagg aggactcgat ccttaccacg gttgttatta   1260

ttattattat aattattatt aaagagtcga gtctgacttt cgactcagtt gaggaggcac   1320

agggaggttg cctgtgcctc cccgagtggc agattccatt gactctgccc catcgctctc   1380

ccctttgaac ttttggagag gatagaactc taagccgtgt ttacagaatg ttgtgcagct   1440

ttgcttcttt gcctctctct ccctgagggg accaaaccat cccaacgtta acgttgtcac   1500

ttgaaaagag aaaggaccaa ccggccccca ccccacccca ccccccgcac tgctttcgtg   1560

aattttgtaa actatgtttg tgtgagtagc gatattgtca gccttctaaa agcaagtgga   1620

gaacacttta aaatatagag gatttctttt tttataagaa aatgctaaat atttatggcc   1680

atgtacacgt tctgacaact ggtggcaaat ttcgctcctt cgttgtaaat atcgctagtg   1740

atcgttgcca aatgacgttc tggatgggcc tgtatcccca ccgggcctgc ctctctttgt   1800

cgtttgtttt cggtgggtta tgtttgagtt gcatcgggtt tttattttta tttttatttt   1860

tattttattt ttattttatt tttaatttgt tcagtgcaaa catttttcaa ctatgaaaaa   1920

ggaaaatatg tgtagggaac tcaccccccg ggcccccttt ttcgtctcct gagcatcgga   1980

gcttggaact cagcagtttc acgtggtttc cccaagagng ccgggc                  2026


<210>  19
<211>  273
<212>  PRT
<213>  Mus musculus

<400>  19

Met Ser Leu Thr Asn Thr Lys Thr Gly Phe Ser Val Lys Asp Ile Leu 
1               5                   10                  15      


Asp Leu Pro Asp Thr Asn Asp Glu Asp Gly Ser Val Ala Glu Gly Pro 
            20                  25                  30          


Glu Glu Glu Ser Glu Gly Pro Glu Pro Ala Lys Arg Ala Gly Pro Leu 
        35                  40                  45              


Gly Gln Gly Ala Leu Asp Ala Val Gln Ser Leu Pro Leu Lys Ser Pro 
    50                  55                  60                  


Phe Tyr Asp Ser Ser Asp Asn Pro Tyr Thr Arg Trp Leu Ala Ser Thr 
65                  70                  75                  80  


Glu Gly Leu Gln Tyr Ser Leu His Gly Leu Ala Ala Ser Ala Pro Pro 
                85                  90                  95      


Gln Asp Ser Ser Ser Lys Ser Pro Glu Pro Ser Ala Asp Glu Ser Pro 
            100                 105                 110         


Asp Asn Asp Lys Glu Thr Gln Gly Gly Gly Gly Asp Ala Gly Lys Lys 
        115                 120                 125             


Arg Lys Arg Arg Val Leu Phe Ser Lys Ala Gln Thr Tyr Glu Leu Glu 
    130                 135                 140                 


Arg Arg Phe Arg Gln Gln Arg Tyr Leu Ser Ala Pro Glu Arg Glu His 
145                 150                 155                 160 


Leu Ala Ser Leu Ile Arg Leu Thr Pro Thr Gln Val Lys Ile Trp Phe 
                165                 170                 175     


Gln Asn His Arg Tyr Lys Met Lys Arg Ala Arg Ala Glu Lys Gly Met 
            180                 185                 190         


Glu Val Thr Pro Leu Pro Ser Pro Arg Arg Val Ala Val Pro Val Leu 
        195                 200                 205             


Val Arg Asp Gly Lys Pro Cys His Ala Leu Lys Ala Gln Asp Leu Ala 
    210                 215                 220                 


Ala Ala Thr Phe Gln Ala Gly Ile Pro Phe Ser Ala Tyr Ser Ala Gln 
225                 230                 235                 240 


Ser Leu Gln His Met Gln Tyr Asn Ala Gln Tyr Ser Ser Ala Ser Thr 
                245                 250                 255     


Pro Gln Tyr Pro Thr Ala His Pro Leu Val Gln Ala Gln Gln Trp Thr 
            260                 265                 270         


Trp 
    


<210>  20
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA mTm4 ob184_sense

<400>  20
gatccccgcc atattgtctc tttgtatatt caagagatat acaaagagac aatatggctt     60

tttggaaa                                                              68


<210>  21
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA mTm4 ob184_antisense

<400>  21
agcttttcca aaaagccata ttgtctcttt gtatatctct tgaatataca aagagacaat     60

atggcggg                                                              68


<210>  22
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA mTm4 idt7_sense

<400>  22
gatccccgcc tgtttgacta atgtgtctgg ttcaagagac cagacacatt agtcaaacag     60

gctttttgga aa                                                         72


<210>  23
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA mTm4 idt7_antisense

<400>  23
agcttttcca aaaagcctgt ttgactaatg tgtctggtct cttgaaccag acacattagt     60

caaacaggcg gg                                                         72


<210>  24
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA mTm4 ob188_sense

<400>  24
gatcccccca cgatggtgat tatctaaatt caagagagcc tgtttgacta atgtgtctgg     60

tttttggaaa                                                            70


<210>  25
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA mTm4 ob188_antisense

<400>  25
agcttttcca aaaaccacga tggtgattat ctaaatctct tgaagcctgt ttgactaatg     60

tgtctggggg                                                            70


<210>  26
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA mTm4 dh1_sense

<400>  26
gatccccgca taactcaagt ggataattca agagattatc cacttgagtt atgctttttg     60

gaaa                                                                  64


<210>  27
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; siRNA mTm4 dh1_antisense

<400>  27
agcttttcca aaaagcataa ctcaagtgga taatctcttg aattatccac ttgagttatg     60

cggg                                                                  64


<210>  28
<211>  1354
<212>  DNA
<213>  Mus musculus

<400>  28
agtgtctcca aggttcaaag aactctgata tttggtccca cttttcttat tgaccccggt     60

acagccactg gaacgtgctg ctgcaatccc tgaggagaac cgtcaagctg gtggcgacga    120

gcctttgatc tctgtgcttt cctgtgaccc cccagcatgt gtactggggg ctgtgccagg    180

tgcctggggg gcaccctcat tcccctggct gtgtttggcc tcctggcaaa tatcctgttg    240

ttctttcctg gaggaaaagt ggtgaacgac aaaagccacc tttcggatga ggtctggtac    300

ttcggaggaa tattgggaag tggagtcttg atgatcttcc ctgcgcttgt gttcttgggc    360

ctgcagaaca acgactgctg cggatgctgt ggcaatgagg gctgtgggaa gcgatttgcg    420

atgttcacct ccacgttgtt tgctgtgatt ggattcttag gtgctggcta ctcatttatc    480

gtctcagctg tttctatcaa caagggtcct aaatgcttca tggccaatgg tacatgggga    540

taccccttcc acgatggtga ttatctaaaa gaccaagcct tgtggagcga gtgcgaagag    600

ccccgtgatg tggtcccctg gaacctcacc ctcttctcca ttctgctggt catcggaggg    660

atccagatgg ttctctgtgc catccaggtg atcaatggcc tcctgggaac tctctgtgga    720

gactgccagt gctgtggctg ctgtgggggt gatggaccag tctaacaggt tatgatgagc    780

tgctccacgt ctacagtcca gcgcgtggga agacatgccc caggcccagc cctgaccaca    840

tgtgttgcta attcctgtct ggttcctctc tggcagagct tgggaggcac aagagatcct    900

tttctctttc caaacagctt tgcacaatct agaaattcgg tggggttttt tttttttttc    960

aaataaaaaa ctagttagat aactttacaa attaggtcct ttcttgaatt ccagaacgag   1020

ttcaaagtag tttttttttt ttcattcttt cccataagaa aagacaaaat agacaaggtc   1080

acttatcctg ccatattgtc tctttgtata taaagatgtt catattttag gaatatttgc   1140

ataactcaag tggataaaac attaaaatga aaaccagttt ttcaggatgc ataggtaagg   1200

aatgattgct atattatata taatttttat gtgaagcctg tttgactaat gtgtctggac   1260

tacttgtaac tagttttatg agcctgtcat aatttgtcag ggttcccata tgtatattaa   1320

gttaattaaa ttcagaatta aaaaaaaaaa aaaa                               1354


<210>  29
<211>  202
<212>  PRT
<213>  Mus musculus

<400>  29

Met Cys Thr Gly Gly Cys Ala Arg Cys Leu Gly Gly Thr Leu Ile Pro 
1               5                   10                  15      


Leu Ala Val Phe Gly Leu Leu Ala Asn Ile Leu Leu Phe Phe Pro Gly 
            20                  25                  30          


Gly Lys Val Val Asn Asp Lys Ser His Leu Ser Asp Glu Val Trp Tyr 
        35                  40                  45              


Phe Gly Gly Ile Leu Gly Ser Gly Val Leu Met Ile Phe Pro Ala Leu 
    50                  55                  60                  


Val Phe Leu Gly Leu Gln Asn Asn Asp Cys Cys Gly Cys Cys Gly Asn 
65                  70                  75                  80  


Glu Gly Cys Gly Lys Arg Phe Ala Met Phe Thr Ser Thr Leu Phe Ala 
                85                  90                  95      


Val Ile Gly Phe Leu Gly Ala Gly Tyr Ser Phe Ile Val Ser Ala Val 
            100                 105                 110         


Ser Ile Asn Lys Gly Pro Lys Cys Phe Met Ala Asn Gly Thr Trp Gly 
        115                 120                 125             


Tyr Pro Phe His Asp Gly Asp Tyr Leu Lys Asp Gln Ala Leu Trp Ser 
    130                 135                 140                 


Glu Cys Glu Glu Pro Arg Asp Val Val Pro Trp Asn Leu Thr Leu Phe 
145                 150                 155                 160 


Ser Ile Leu Leu Val Ile Gly Gly Ile Gln Met Val Leu Cys Ala Ile 
                165                 170                 175     


Gln Val Ile Asn Gly Leu Leu Gly Thr Leu Cys Gly Asp Cys Gln Cys 
            180                 185                 190         


Cys Gly Cys Cys Gly Gly Asp Gly Pro Val 
        195                 200         


<210>  30
<211>  1066
<212>  DNA
<213>  Danio rerio

<400>  30
atgaattcag ggtgtgtgtg tgtgagactc agagatcaaa ctttctgcta gggtctttta     60

tcaacactgt agagattaca gaggttattc tcaggcgtca ggattaaacc tatctcacat    120

catgtgtacc ggaaaatgtg cattttgcgt cgggacgagc ctgtacccgc tggcggtcat    180

ctccataatc tgtaatatta ttctgttttt tcctggctgg ggtgttaagt actcgcagaa    240

tggacaactt actgaggagg tcaagtacat ggggggactg gtcggagggg gagtaatggt    300

gctgattcca gcatttcaca ttcacctgac tggaaaacaa ggttgctgtg ctaatcgctg    360

tgggatgttc ctgtccattt tatttgcagc agtaggcgtt gttggcgctc tctatagttt    420

catagtagcg ctgatgggtc taattaatgg gccatactgt ttatctagct ttagttggac    480

cactcccttt aaagacagga acgagagtta ccttaaggac cgtgactcat ggaaagattg    540

caccgagccg aagaatgtgg tggagtttaa tgtgggtctg ttctccacac tactggtgac    600

cagtgctgtg cagctcgtcc tttgtgcagt gcagatgatc aacggtcttt tcggctgcct    660

ctgtggaacc tgcaaaaaag acaaggggcc gctgtaactc cttactgctc caaacgcccg    720

ggagaccata tccatcacac ctgccaccca gcctcccaat cagctaccga gcgccatctt    780

ctggaagatg ttgaagaatt taatggaatg tgtttgtact ttgtgtgtgt acacgtaaat    840

cttttcatat tttgatgttt attgcttaca ttttttctta ctactgtttt ttaagtaaag    900

gcatatgcgt aatgacttct agagccaatc atatttttta aagaaagttg cgttaattaa    960

tggcataaca ctcgttttgt atgcatctgt tttttatagg ttaaagatta aatgaacata   1020

ctaagaataa aatccaaact gttacacaaa aaaaaaaaaa aaaaaa                  1066


<210>  31
<211>  191
<212>  PRT
<213>  Danio rerio

<400>  31

Met Cys Thr Gly Lys Cys Ala Phe Cys Val Gly Thr Ser Leu Tyr Pro 
1               5                   10                  15      


Leu Ala Val Ile Ser Ile Ile Cys Asn Ile Ile Leu Phe Phe Pro Gly 
            20                  25                  30          


Trp Asp Val Lys Tyr Ser Gln Asn Gly Gln Leu Thr Glu Glu Val Lys 
        35                  40                  45              


Tyr Met Gly Gly Leu Val Gly Gly Gly Val Met Val Leu Ile Pro Ala 
    50                  55                  60                  


Phe His Ile His Leu Thr Gly Lys Gln Gly Cys Cys Ala Asn Arg Cys 
65                  70                  75                  80  


Gly Met Phe Leu Ser Ile Leu Phe Ala Ala Val Gly Val Val Gly Ala 
                85                  90                  95      


Leu Tyr Ser Phe Ile Val Ala Leu Met Gly Leu Ile Asn Gly Pro Tyr 
            100                 105                 110         


Cys Leu Ser Ser Phe Ser Trp Thr Thr Pro Phe Lys Asp Arg Asn Glu 
        115                 120                 125             


Ser Tyr Leu Lys Asp Arg Asp Ser Trp Lys Asp Cys Thr Glu Pro Lys 
    130                 135                 140                 


Asn Val Val Glu Phe Asn Val Gly Leu Phe Ser Thr Leu Leu Val Thr 
145                 150                 155                 160 


Ser Ala Val Gln Leu Val Leu Cys Ala Val Gln Met Ile Asn Gly Leu 
                165                 170                 175     


Phe Gly Cys Leu Cys Gly Thr Cys Lys Lys Asp Lys Gly Pro Leu 
            180                 185                 190     


<210>  32
<211>  2092
<212>  DNA
<213>  Homo sapiens

<400>  32
gcggccgccg gagcccgagc tgacgccgcc ttggcacccc tcctggagtt agaaactaag     60

gccggggccc gcggcgctcg gcgcgcaggc cgcccggctt cctgcgtcca tttccgcgtg    120

ctttcaaaga agacagagag aggcactggg ttgggcttca tttttttcct ccccatcccc    180

agtttctttc tctttttaaa aataataatt atcccaataa ttaaagccaa ttcccccctc    240

ccctccccca gtccctcccc ccaactcccc cctcccccgc ccgccggggc aggggagcgc    300

cacgaattga ccaagtgaag ctacaacttt gcgacataaa ttttggggtc tcgaaccatg    360

tcgctgacca acacaaagac ggggttttcg gtcaaggaca tcttagacct gccggacacc    420

aacgatgagg agggctctgt ggccgaaggt ccggaggaag agaacgaggg gcccgagcca    480

gccaagaggg ccgggccgct ggggcagggc gccctggacg cggtgcagag cctgcccctg    540

aagaacccct tctacgacag cagcgacaac ccgtacacgc gctggctggc cagcaccgag    600

ggccttcagt actccctgca cggtctggct gccggggcgc cccctcagga ctcaagctcc    660

aagtccccgg agccctcggc cgacgagtca ccggacaatg acaaggagac cccgggcggc    720

gggggggacg ccggcaagaa gcgaaagcgg cgagtgcttt tctccaaggc gcagacctac    780

gagctggagc ggcgctttcg gcagcagcgg tacctgtcgg cgcccgagcg cgaacacctg    840

gccagcctca tccgcctcac gcccacgcag gtcaagatct ggttccagaa ccaccgctac    900

aagatgaagc gcgcccgggc cgagaaaggt atggaggtga cgcccctgcc ctcgccgcgc    960

cgggtggccg tgcccgtctt ggtcagggac ggcaaaccat gtcacgcgct caaagcccag   1020

gacctggcag ccgccacctt ccaggcgggc attccctttt ctgcctacag cgcgcagtcg   1080

ctgcagcaca tgcagtacaa cgcccagtac agctcggcca gcacccccca gtacccgaca   1140

gcacaccccc tggtccaggc ccagcagtgg acttggtgag cgccgcccca acgagactcg   1200

cggccccagg cccaggcccc accccggcgg cggtggcggc gaggaggcct cggtccttat   1260

ggtggttatt attattatta taattattat tatggagtcg agttgactct cggctccact   1320

agggaggcgc cgggaggttg cctgcgtctc cttggagtgg cagattccac ccacccagct   1380

ctgcccatgc ctctccttct gaaccttggg agagggctga actctacgcc gtgtttacag   1440

aatgtttgcg cagcttcgct tctttgcctc tccccggggg gaccaaaccg tcccagcgtt   1500

aatgtcgtca cttgaaaacg agaaaaagac cgacccccca cccctgcttt cgtgcatttt   1560

gtaaaatatg tttgtgtgag tagcgatatt gtcagccgtc ttctaaagca agtggagaac   1620

actttaaaaa tacagagaat ttcttccttt ttttaaaaaa aaataagaaa atgctaaata   1680

tttatggcca tgtaaacgtt ctgacaactg gtggcagatt tcgcttttcg ttgtaaatat   1740

cggtggtgat tgttgccaaa atgaccttca ggaccggcct gtttcccgtc tgggtccaac   1800

tcctttcttt gtggcttgtt tgggtttgtt ttttgttttg tttttgtttt tgcgttttcc   1860

cctgctttct tcctttctct ttttatttta ttgtgcaaac atttctcaaa tatggaaaag   1920

aaaaccctgt aggcagggag ccctctgccc tgtcctccgg gccttcagcc ccgaacttgg   1980

agctcagcta ttcggcgcgg ttccccaaca gcgccgggcg cagaaagctt tcgatttttt   2040

aaataagaat tttaataaaa atcctgtgtt taaaaaagaa aaaaagaaaa aa           2092


<210>  33
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Leu Thr Asn Thr Lys Thr Gly Phe Ser Val Lys Asp Ile Leu 
1               5                   10                  15      


Asp Leu Pro Asp Thr Asn Asp Glu Glu Gly Ser Val Ala Glu Gly Pro 
            20                  25                  30          


Glu Glu Glu Asn Glu Gly Pro Glu Pro Ala Lys Arg Ala Gly Pro Leu 
        35                  40                  45              


Gly Gln Gly Ala Leu Asp Ala Val Gln Ser Leu Pro Leu Lys Asn Pro 
    50                  55                  60                  


Phe Tyr Asp Ser Ser Asp Asn Pro Tyr Thr Arg Trp Leu Ala Ser Thr 
65                  70                  75                  80  


Glu Gly Leu Gln Tyr Ser Leu His Gly Leu Ala Ala Gly Ala Pro Pro 
                85                  90                  95      


Gln Asp Ser Ser Lys Ser Pro Glu Pro Ser Ala Asp Glu Ser Pro Asp 
            100                 105                 110         


Asn Asp Lys Glu Thr Pro Gly Gly Gly Gly Asp Ala Gly Lys Lys Arg 
        115                 120                 125             


Lys Arg Arg Val Leu Phe Ser Lys Ala Gln Thr Tyr Glu Leu Glu Arg 
    130                 135                 140                 


Arg Phe Arg Gln Gln Arg Tyr Leu Ser Ala Pro Glu Arg Glu His Leu 
145                 150                 155                 160 


Ala Ser Leu Ile Arg Leu Thr Pro Thr Gln Val Lys Ile Trp Phe Gln 
                165                 170                 175     


Asn His Arg Tyr Lys Met Lys Arg Ala Arg Ala Glu Lys Gly Met Glu 
            180                 185                 190         


Val Thr Pro Leu Pro Ser Pro Arg Arg Val Ala Val Pro Val Leu Val 
        195                 200                 205             


Arg Asp Gly Lys Pro Cys His Ala Leu Lys Ala Gln Asp Leu Ala Ala 
    210                 215                 220                 


Ala Thr Phe Gln Ala Gly Ile Pro Phe Ser Ala Tyr Ser Ala Gln Ser 
225                 230                 235                 240 


Leu Gln His Met Gln Tyr Asn Ala Gln Tyr Ser Ser Ala Ser Thr Pro 
                245                 250                 255     


Gln Tyr Pro Thr Ala His Pro Leu Val Gln Ala Gln Gln Trp Thr Trp 
            260                 265                 270         


<210>  34
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; antibody epitope

<400>  34

Cys Gly Thr Trp Gly Tyr Pro Phe His Asp Gly Asp Tyr Leu Lys Asp 
1               5                   10                  15      


<210>  35
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  35
agtcactttt ttttcaagaa atcttttata agaattaaac ccatgcttaa tattaataac     60

taggcggccg catttaaatg gc                                              82


<210>  36
<211>  83
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  36
ctacaggcag atccagaata tctagctctt tatcccttac aggggcagcc agattgaaga     60

acatcgatga tatcagatct gcc                                             83


<210>  37
<211>  86
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  37
aagctggtgg cgacgagcct ttgatctctg tgctttcctg tgacccccca gcatgtgtgc     60

tcgagacgta gaaagccagt ccgcag                                          86


<210>  38
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  38
caagactcca cttcccaata ttcctccgaa gtaccagacc tcatccgaaa ggtggctttt     60

cgtacgcaaa attcagaaga actcgtcaag                                      90


<210>  39
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  39
catcagggtg tcatggttgg t                                               21


<210>  40
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  40
tctcttgctc tgagcctcat ca                                              22


<210>  41
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  41
tgggacagaa agacagcta                                                  19


<210>  42
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  42
tcctcagtcc gactcagaaa cc                                              22


<210>  43
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  43
gcttctcttc tgcccactct tg                                              22


<210>  44
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  44
agggtcgaag gcca                                                       14


<210>  45
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  45
aagcgaggag acgatccaaa                                                 20


<210>  46
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  46
tccaacacac accagcaaat g                                               21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  47
acatttcata tcatctcatc c                                               21


<210>  48
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  48
gagccccttc tgggtttcc                                                  19


<210>  49
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  49
aagtcagcca cctcagtttc ct                                              22


<210>  50
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  50
tcctcctaaa tctgcc                                                     16


<210>  51
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  51
aaccacggac agcatccaat                                                 20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  52
tttgcggacg tgtcttgaga                                                 20


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  53
tcattacacg gcctgtccgc gaa                                             23


<210>  54
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  54
cacacgcacg catggaaa                                                   18


<210>  55
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  55
tcctcggcct cgaccatat                                                  19


<210>  56
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  56
cagtggacag gccct                                                      15


<210>  57
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  57
gccaaactcc gccaacttc                                                  19


<210>  58
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  58
ctggcgagtt cctgttttcc                                                 20


<210>  59
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  59
atctctcctc agccctg                                                    17


<210>  60
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  60
gcaaagttct agagggcatg ga                                              22


<210>  61
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  61
cccggctgtc tgtcttggt                                                  19


<210>  62
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  62
tggtacggaa ggtggag                                                    17


<210>  63
<211>  3121
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (15)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (755)..(760)
<223>  n is a, c, g, or t

<400>  63
ttaattaaga attcnnnnnn ccatggtgag caagggcgag gagctgttca ccggggtggt     60

gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga    120

gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa    180

gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag    240

ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta    300

cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt    360

gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga    420

ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat    480

catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga    540

ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc    600

cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa    660

cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg    720

catggacgag ctgtacaagt aaagcggccg cgacnnnnnn tctagggctg taagtctgca    780

gaaattgatg atctattaaa caataaagat gtccactaaa atggaagttt ttcctgtcat    840

actttgttaa gaagggtgag aacagagtac ctacattttg aatggaagga ttggagctac    900

gggggtgggg gtggggtggg attagataaa tgcctgctct ttactgaagg ctctttacta    960

ttgctttatg ataatgtttc atagttggat atcataattt aaacaagcaa aaccaaatta   1020

agggccagct cattcctccc actcatgatc tatagatcta tagatctctc gtgggatcat   1080

tgtttttctc ttgattccca ctttgtggtt ctaagtactg tggtttccaa atgtgtcagt   1140

ttcatagcct gaagaacgag atcagcagcc tctgttccac atacacttca ttctcagtat   1200

tgttttgcca agttctaatt ccatcagaag cttctagaca ttaaataact tcgtataatg   1260

tatgctatac gaagttatga attctaccgg gtaggggagg cgcttttccc aaggcagtct   1320

ggagcatgcg ctttagcagc cccgctgggc acttggcgct acacaagtgg cctctggcct   1380

cgcacacatt ccacatccac cggtaggcgc caaccggctc cgttctttgg tggccccttc   1440

gcgccacctt ctactcctcc cctagtcagg aagttccccc ccgccccgca gctcgcgtcg   1500

tgcaggacgt gacaaatgga agtagcacgt ctcactagtc tcgtgcagat ggacagcacc   1560

gctgagcaat ggaagcgggt aggcctttgg ggcagcggcc aatagcagct ttgctccttc   1620

gctttctggg ctcagaggct gggaaggggt gggtccgggg gcgggctcag gggcgggctc   1680

aggggcgggg cgggcgcccg aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag   1740

cgcacgtctg ccgcgctgtt ctcctcttcc tcatctccgg gcctttcgac tgcagccaat   1800

atgggatcgg ccattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag   1860

aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc   1920

cggctgtcag cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg   1980

aatgaactgc aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc   2040

gcagctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg   2100

ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct   2160

gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg   2220

aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat   2280

ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc   2340

atgcccgacg gcgatgatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg   2400

gtggaaaatg gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc   2460

tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct   2520

gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat   2580

cgccttcttg acgagttctt ctgaggggat ccgctgtaag tctgcagaaa ttgatgatct   2640

attaaacaat aaagatgtcc actaaaatgg aagtttttcc tgtcatactt tgttaagaag   2700

ggtgagaaca gagtacctac attttgaatg gaaggattgg agctacgggg gtgggggtgg   2760

ggtgggatta gataaatgcc tgctctttac tgaaggctct ttactattgc tttatgataa   2820

tgtttcatag ttggatatca taatttaaac aagcaaaacc aaattaaggg ccagctcatt   2880

cctcccactc atgatctata gatctataga tctctcgtgg gatcattgtt tttctcttga   2940

ttcccacttt gtggttctaa gtactgtggt ttccaaatgt gtcagtttca tagcctgaag   3000

aacgagatca gcagcctctg ttccacatac acttcattct cagtattgtt ttgccaagtt   3060

ctaattccat cagaagctta taacttcgta taatgtatgc tatacgaagt tatttaatta   3120

a                                                                   3121


<210>  64
<211>  1212
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (735)..(740)
<223>  n is a, c, g, or t

<400>  64
ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg gtcgagctgg     60

acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc gatgccacct    120

acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg ccctggccca    180

ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc gaccacatga    240

agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag cgcaccatct    300

tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc    360

tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac atcctggggc    420

acaagctgga gtacaactac aacagccaca acgtctatat catggccgac aagcagaaga    480

acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc gtgcagctcg    540

ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg cccgacaacc    600

actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc gatcacatgg    660

tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag ctgtacaagt    720

aaagcggccg cgacnnnnnn tctagggctg taagtctgca gaaattgatg atctattaaa    780

caataaagat gtccactaaa atggaagttt ttcctgtcat actttgttaa gaagggtgag    840

aacagagtac ctacattttg aatggaagga ttggagctac gggggtgggg gtggggtggg    900

attagataaa tgcctgctct ttactgaagg ctctttacta ttgctttatg ataatgtttc    960

atagttggat atcataattt aaacaagcaa aaccaaatta agggccagct cattcctccc   1020

actcatgatc tatagatcta tagatctctc gtgggatcat tgtttttctc ttgattccca   1080

ctttgtggtt ctaagtactg tggtttccaa atgtgtcagt ttcatagcct gaagaacgag   1140

atcagcagcc tctgttccac atacacttca ttctcagtat tgttttgcca agttctaatt   1200

ccatcagaag ct                                                       1212


<210>  65
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  65
ataacttcgt ataatgtatg ctatacgaag ttat                                 34


<210>  66
<211>  1801
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  66
gaattctacc gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca     60

gccccgctgg gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc    120

accggtaggc gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct    180

cccctagtca ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg    240

gaagtagcac gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg    300

gtaggccttt ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg    360

ctgggaaggg gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc    420

cgaaggtcct ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg    480

ttctcctctt cctcatctcc gggcctttcg actgcagcca atatgggatc ggccattgaa    540

caagatggat tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac    600

tgggcacaac agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg    660

cgcccggttc tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaggacgag    720

gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt    780

gtcactgaag cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg    840

tcatctcacc ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg    900

catacgcttg atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga    960

gcacgtactc ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag   1020

gggctcgcgc cagccgaact gttcgccagg ctcaaggcgc gcatgcccga cggcgatgat   1080

ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt   1140

tctggattca tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg   1200

gctacccgtg atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt   1260

tacggtatcg ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc   1320

ttctgagggg atccgctgta agtctgcaga aattgatgat ctattaaaca ataaagatgt   1380

ccactaaaat ggaagttttt cctgtcatac tttgttaaga agggtgagaa cagagtacct   1440

acattttgaa tggaaggatt ggagctacgg gggtgggggt ggggtgggat tagataaatg   1500

cctgctcttt actgaaggct ctttactatt gctttatgat aatgtttcat agttggatat   1560

cataatttaa acaagcaaaa ccaaattaag ggccagctca ttcctcccac tcatgatcta   1620

tagatctata gatctctcgt gggatcattg tttttctctt gattcccact ttgtggttct   1680

aagtactgtg gtttccaaat gtgtcagttt catagcctga agaacgagat cagcagcctc   1740

tgttccacat acacttcatt ctcagtattg ttttgccaag ttctaattcc atcagaagct   1800

t                                                                   1801


