                         SEQUENCE LISTING

<110>  MedImmune LLC
       Yang, Chin-Fen
       Kemble, George
 
<120>  INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS

<130>  FL250PCT3

<150>  61/079,894
<151>  2008-07-11

<150>  61/110,702
<151>  2008-11-03

<150>  61/178,592
<151>  2009-05-15

<160>  28    

<170>  PatentIn version 3.3

<210>  1
<211>  1757
<212>  DNA
<213>  Influenza A virus

<400>  1
aaagcagggg ataattctat taaccatgaa gactatcatt gctttgagct acattctatg     60

tctggttttc gctcaaaaac ttcctggaaa tgacaacagc acggcaacgc tgtgccttgg    120

gcaccatgca gtaccaaacg gaacgatagt gaaaacaatc acgaatgacc aaattgaagt    180

tactaatgct actgagctgg ttcagagttc ctcaacaggt gaaatatgcg acagtcctca    240

tcagatcctt gatggagaaa actgcacact aatagatgct ctattgggag accctcagtg    300

tgatggcttc caaaataaga aatgggacct ttttgttgaa cgcagcaaag cctacagcaa    360

ctgttaccct tatgatgtgc cggattatgc ctcccttagg tcactagttg cctcatccgg    420

cacactggag tttaacaatg aaagcttcaa ttggactgga gtcactcaaa acggaacaag    480

ctcttcttgc ataaggagat ctaataacag tttctttagt agattgaatt ggttgaccca    540

cttaaaattc aaatacccag cattgaacgt gactatgcca aacaatgaaa aatttgacaa    600

attgtacatt tggggggttc accacccggg tacggacaat gaccaaatct tcccgtatgc    660

tcaagcatca ggaagaatca cagtctctac caaaagaagc caacaaactg taatcccgaa    720

tatcggatct agacccagag taaggaatat ccccagcaga ataagcatct attggacaat    780

agtaaaaccg ggagacatac ttttgattaa cagcacaggg aatctaattg ctcctagggg    840

ttacttcaaa atacgaagtg ggaaaagctc aataatgaga tcagatgcac ccattggcaa    900

atgcaattct gaatgcatca ctccaaatgg gagcattccc aatgacaaac cattccaaaa    960

tgtaaacagg atcacatacg gggcctgtcc cagatatgtt aagcaaaaca ctctgaaatt   1020

ggcaacaggg atgcgaaatg taccagagaa acaaactaga ggcatatttg gcgcaatcgc   1080

gggtttcata gaaaatggtt gggagggaat ggtggatggt tggtacggtt tcaggcatca   1140

aaattctgag ggaataggac aagcagcaga tctcaaaagc actcaagcag caatcgatca   1200

aatcaatggg aagctgaata ggttgatcgg gaaaaccaac gagaaattcc atcagattga   1260

aaaggaattc tcagaagtcg aagggaggat tcaggacctt gagaaatatg ttgaggacac   1320

caaaatagat ctctggtcat acaacgcgga gcttcttgtt gccctggaga accaacatac   1380

aattgatcta actgactcag aaatgaacaa actgtttgaa aaaacaaaga agcaactgag   1440

ggaaaatgct gaggatatgg gcaatggttg tttcaaaata taccacaaat gtgacaatgc   1500

ctgcatagga tcaatcagaa atggaactta tgaccacgat gtatacagag atgaagcatt   1560

aaacaaccgg ttccagatca agggcgttga gctgaagtca ggatacaaag attggatcct   1620

atggatttcc tttgccatat catgtttttt gctttgtgtt gctttgttgg ggttcatcat   1680

gtgggcctgc caaaaaggca acattaggtg caacatttgc atttgagtgc attaattaaa   1740

aacacccttg tttctac                                                  1757


<210>  2
<211>  566
<212>  PRT
<213>  Influenza A virus

<400>  2

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Phe Pro Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  3
<211>  1458
<212>  DNA
<213>  Influenza A virus

<400>  3
gcaaaagcag gagtaaagat gaatccaaat caaaagataa taacgattgg ctctgtttct     60

ctcaccattt ccacaatatg cttcttcatg caaactgcca tcttgataac tactgtaaca    120

ttgcatttca agcaatatga attcaactcc cccccaaaca accaagtgat gctgtgtgaa    180

ccaacaataa tagaaagaaa cataacagag atagtgtatc tgaccaacac caccatagag    240

aaggaaatat gccccaaact agcagaatac agaaattggt caaagccgca atgtgacatt    300

acaggatttg cacctttttc taaggacaat tcgattaggc tttccgctgg tggggacatc    360

tgggtgacaa gagaacctta tgtgtcatgc gatcctgaca agtgttatca atttgccctt    420

ggacagggaa caacactaaa caacgtgcat tcaaatgaca cagtacatga taggacccct    480

tatcggaccc tattgatgaa tgagttaggt gttccttttc atctggggac caagcaagtg    540

tgcatagcat ggtccagctc aagttgtcac gatggaaaag catggctgca tgtttgtata    600

acgggggatg ataaaaatgc aactgctagc ttcatttaca atgggaggct tgtagatagt    660

attgtttcat ggtccaaaga aatcctcagg acccaggagt cagaatgcgt ttgtatcaat    720

ggaacttgta cagtagtaat gactgatggg agtgcttcag gaaaagctga tactaaaata    780

ctattcattg aggaggggaa aatcgttcat actagcatat tgtcaggaag tgctcagcat    840

gtcgaggagt gctcctgcta tcctcgatat cctggtgtca gatgtgtctg cagagacaac    900

tggaaaggct ccaataggcc catcgtagat ataaacataa aggatcatag cattgtttcc    960

agttatgtgt gttcaggact tgttggagac acacccagaa aaaacgacag ctccagcagt   1020

agccattgtt tggatcctaa caatgaagaa ggtggtcatg gagtgaaagg ctgggccttt   1080

gatgatggaa atgacgtgtg gatgggaaga acgatcagcg agaagtcacg cttagggtat   1140

gaaaccttca aagtcattga aggctggtcc aaccctaagt ccaaattgca gataaatagg   1200

caagtcatag ttgacagagg taataggtcc ggttattctg gtattttctc tgttgaaggc   1260

aaaagctgca tcaatcggtg cttttatgtg gagttgataa ggggaagaaa agaggaaact   1320

gaagtcttgt ggacctcaaa cagtattgtt gtgttttgtg gcacctcagg tacatatgga   1380

acaggctcat ggcctgatgg ggcggacatc aatctcatgc ctatataagc tttcgcaatt   1440

ttagaaaaaa actccttg                                                 1458


<210>  4
<211>  469
<212>  PRT
<213>  Influenza A virus

<400>  4

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Thr Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Leu Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asp Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Ile Val Ser Trp Ser Lys Glu Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Ile Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu 
        355                 360                 365             


Lys Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asn Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile 
    450                 455                 460                 


Asn Leu Met Pro Ile 
465                 


<210>  5
<211>  1771
<212>  DNA
<213>  Influenza A virus

<400>  5
aaaagcaggg gaaaataaaa acaaccagaa tgaaagtaaa actactggtc ctgttatgca     60

catttacagc tacatatgca gacacaatat gtataggcta ccatgctaac aactcgaccg    120

acactgttga cacagtactt gaaaagaatg tgacagtgac acactctgtc aacctgcttg    180

agaacagtca caatggaaga ctatgtctat taaaaggaat agccccacta caattgggta    240

actgcagcgt tgccgggtgg atcttaggaa acccagaatg cgaattactg atttccaagg    300

agtcatggtc ctacattgta gaaaaaccaa atcctgagaa tggaacatgt tacccagggc    360

atttcgctga ctatgaggaa ctgagggagc aattgagttc agtatcttca cttgagaggt    420

tcgaaatatt ccccaaagaa agctcatggc ccaaccacac cgtaaccgga gtgtcagcat    480

catgctccca taatggggaa agcagttttt acagaaattt gctatggctg acggggaaga    540

atggtttgta cccaaacctg agcaagtcct atgcaaacaa caaagaaaaa gaagtccttg    600

tactatgggg tgttcatcac ccgccaaaca taggtaacca aaaggccctc tatcatacag    660

aaaatgctta tgtttctgta gtgtcttcac attatagcag aaaattcacc ccagaaatag    720

ccaaaagacc caaagtaaga gatcaagaag gaagaatcaa ctactactgg actctgcttg    780

aacccgggga tacaataata tttgaggcaa atggaaatct aatagcgcca agatatgctt    840

tcgcactgag tagaggcttt ggatcaggaa tcatcaactc aaatgcacca atggataaat    900

gtgatgcgaa gtgccaaaca cctcagggag ctataaacag cagtcttcct ttccagaacg    960

tacacccagt cacaatagga gagtgtccaa agtatgtcag gagtgcaaaa ttaaggatgg   1020

ttacaggact aaggaacatc ccatccattc aatccagagg tttgtttgga gccattgccg   1080

gtttcattga aggggggtgg actggaatgg tagatggttg gtatggttat catcatcaga   1140

atgagcaagg atctggctat gctgcagatc aaaaaagcac acaaaatgcc attaatggga   1200

ttacaaacaa ggtgaattct gtaattgaga aaatgaacac tcaattcaca gcagtgggca   1260

aagaattcaa caaattggaa agaaggatgg aaaacttgaa taaaaaagtt gatgatgggt   1320

ttatagacat ttggacatat aatgcagaac tgttggttct actggaaaat gaaaggactt   1380

tggatttcca tgactccaat gtgaagaatc tgtatgagaa agtaaaaagc cagttaaaga   1440

ataatgctaa agaaatagga aatgggtgtt ttgaattcta tcacaagtgt aacgatgaat   1500

gcatggagag tgtaaagaat ggaacttatg actatccaaa atattccgaa gaatcaaagt   1560

taaacaggga gaaaattgat ggagtgaaat tggaatcaat gggagtctat cagattctgg   1620

cgatctactc aacagtcgcc agttctctgg ttcttttggt ctccctgggg gcaatcagct   1680

tctggatgtg ttccaatggg tctttgcagt gtagaatatg catctaagac cagaatttca   1740

gaaatataag gaaaaacacc cttgtttcta c                                  1771


<210>  6
<211>  565
<212>  PRT
<213>  Influenza A virus

<400>  6

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Ser His Asn Gly Arg Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Leu 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Lys Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Lys Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  7
<211>  1446
<212>  DNA
<213>  Influenza A virus

<400>  7
agcaaaagca ggagtttaaa atgaacccaa atcaaaagat aataaccatt ggatcaatca     60

gtatagcaat cggaataatt agtctaatgt tgcaaatagg aaatattatt tcaatatggg    120

ctagtcactc aatccaaact ggaagtcaaa acaacactgg aatatgcaac caaagaatca    180

tcacatatga aaacagcacc tgggtgaatc acacatatgt taatattaac aacactaatg    240

ttgttgctgg agaggacaaa acttcagtga cattggccgg caattcatct ctttgttcta    300

tcagtggatg ggctatatac acaaaagaca acagcataag aattggctcc aaaggagatg    360

tttttgtcat aagagaacct ttcatatcat gttctcactt ggaatgcaga accttttttc    420

tgacccaagg cgctctatta aatgacaaac attcaaatgg gaccgtaaag gacagaagtc    480

cttatagggc cttaatgagc tgtcctctag gtgaagctcc gtccccatac aattcaaagt    540

tcgaatcagt tgcatggtca gcaagcgcat gccatgatgg catgggctgg ttaacaatcg    600

gaatttctgg tccagacaat ggagctgtgg ctgtactaaa atacaacgga ataataactg    660

gaaccataaa aagttggaaa aagcaaatat taagaacaca agagtctgaa tgtgtctgta    720

tgaacgggtc atgtttcacc ataatgaccg atggcccgag taataaggcc gcctcgtaca    780

aaattttcaa gatcgaaaag gggaaggtta ctaaatcaat agagttgaat gcacccaatt    840

ttcattatga ggaatgctcc tgttacccag acactggcat agtgatgtgt gtatgcaggg    900

acaactggca tggttcaaat cgaccttggg tgtctttcaa tcaaaacttg gattatcaaa    960

taggatacat ctgcagtgga gtgtttggtg acaatccgcg tcccgaagat ggagagggca   1020

gctgcaatcc agtgactgtt gatggagcaa acggagtaaa agggttttca tacaaatatg   1080

ataatggtgt ttggatagga aggaccaaaa gtaacagact tagaaagggg tttgagatga   1140

tttgggatcc taatggatgg acaaataccg acagtgattt ctcagtgaaa caggatgttg   1200

tagcaataac tgattggtca gggtacagcg gaagtttcgt ccaacatcct gagttaacag   1260

gattggactg tataagacct tgcttctggg ttgagttagt cagagggctg cctagagaaa   1320

atacaacaat ctggactagt gggagcagca tttctttttg tggcgttaat agtgatactg   1380

caaactggtc ttggccagac ggtgctgagt tgccgttcac cattgacaag tagttcgttg   1440

aaaaaa                                                              1446


<210>  8
<211>  470
<212>  PRT
<213>  Influenza A virus

<400>  8

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Ser Ile Ala 
1               5                   10                  15      


Ile Gly Ile Ile Ser Leu Met Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ala Ser His Ser Ile Gln Thr Gly Ser Gln Asn Asn Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn His 
    50                  55                  60                  


Thr Tyr Val Asn Ile Asn Asn Thr Asn Val Val Ala Gly Glu Asp Lys 
65                  70                  75                  80  


Thr Ser Val Thr Leu Ala Gly Asn Ser Ser Leu Cys Ser Ile Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Thr Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser 
145                 150                 155                 160 


Cys Pro Leu Gly Glu Ala Pro Ser Pro Tyr Asn Ser Lys Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Gly Thr Ile Lys Ser Trp Lys Lys Gln Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Val Cys Met Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asn Lys Ala Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro 
            260                 265                 270         


Asn Phe His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Ile Val 
        275                 280                 285             


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Glu Gly Ser Cys Asn 
                325                 330                 335     


Pro Val Thr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr Lys 
            340                 345                 350         


Tyr Asp Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asn Thr Asp 
    370                 375                 380                 


Ser Asp Phe Ser Val Lys Gln Asp Val Val Ala Ile Thr Asp Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Val Arg Gly Leu Pro Arg 
            420                 425                 430         


Glu Asn Thr Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly 
        435                 440                 445             


Val Asn Ser Asp Thr Ala Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu 
    450                 455                 460                 


Pro Phe Thr Ile Asp Lys 
465                 470 


<210>  9
<211>  1882
<212>  DNA
<213>  Influenza B virus

<400>  9
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg     60

gtagtaacat ccaatgcaga tcgaatctgc actggaataa catcttcaaa ctcacctcat    120

gtggtcaaaa cagccactca aggggaggtc aatgtgactg gtgtgatacc actaacaaca    180

acaccaacaa aatcttattt tgcaaatctc aaaggaacaa ggaccagagg gaaactatgc    240

ccagactgtc tcaactgcac agatctggat gtggctttgg gcagaccaat gtgtgtgggg    300

accacacctt cggcgaaagc ttcaatactc cacgaagtca aacctgttac atccgggtgc    360

tttcctataa tgcacgacag aacaaaaatc aggcaactac ccaatcttct cagaggatat    420

gaaaatatca ggctatcaac ccaaaacgtc atcgatgcgg aaaaggcacc aggaggaccc    480

tacagacttg gaacctcagg atcttgccct aacgctacca gtaagagcgg atttttcgca    540

acaatggctt gggctgtccc aaaggacaac aacaaaaatg caacgaaccc actaacagta    600

gaagtaccat acatttgtac agaaggggaa gaccaaatca ctgtttgggg gttccattca    660

gatgacaaaa cccaaatgaa gaacctctat ggagactcaa atcctcaaaa gttcacctca    720

tctgctaatg gagtaaccac acactatgtt tctcagattg gcagcttccc agatcaaaca    780

gaagacggag gactaccaca aagcggcagg attgttgttg attacatgat gcaaaaacct    840

gggaaaacag gaacaattgt ctaccaaaga ggtgttttgt tgcctcaaaa ggtgtggtgc    900

gcgagtggca ggagcaaagt aataaaaggg tccttgcctt taattggtga agcagattgc    960

cttcatgaaa aatacggtgg attaaacaaa agcaagcctt actacacagg agaacatgca   1020

aaagccatag gaaattgccc aatatgggtg aaaacacctt tgaagcttgc caatggaacc   1080

aaatatagac ctcctgcaaa actattaaag gaaaggggtt tcttcggagc tattgctggt   1140

ttcctagaag gaggatggga aggaatgatt gcaggctggc acggatacac atctcacgga   1200

gcacatggag tggcagtggc ggcggacctt aagagtacgc aagaagctat aaacaagata   1260

acaaaaaatc tcaattcttt gagtgagcta gaagtaaaga atcttcaaag actaagtggt   1320

gccatggatg aactccacaa cgaaatactc gagctggatg agaaagtgga tgatctcaga   1380

gctgacacta taagctcgca aatagaactt gcagtcttgc tttccaacga aggaataata   1440

aacagtgaag atgagcatct attggcactt gagagaaaac taaagaaaat gctgggtccc   1500

tctgctgtag agataggaaa tggatgcttc gaaaccaaac acaagtgcaa ccagacctgc   1560

ttagacagga tagctgctgg cacctttaat gcaggagaat tttctctccc cacttttgat   1620

tcactgaaca ttactgctgc atctttaaat gatgatggat tggataacca tactatactg   1680

ctctattact caactgctgc ttctagtttg gctgtaacat tgatgctagc tatttttatt   1740

gtttatatgg tctccagaga caacgtttca tgctccatct gtctataagg aagattaggc   1800

cttgtatttt cctttattgt agtgcttgtt tgcttgtcat cattacaaag aaacgttatt   1860

gaaaaatgct cttgttacta ct                                            1882


<210>  10
<211>  584
<212>  PRT
<213>  Influenza B virus

<400>  10

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Asn Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asp Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Ser Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210>  11
<211>  1557
<212>  DNA
<213>  Influenza B virus

<400>  11
agcagaagca gagcatcttc tcaaaactga ggcaaatagg ccaaaaatga acaatgctac     60

cttcaactat acaaacgtta accctatttc tcacatcagg gggagtgtta ttatcactat    120

atgtgtcagc ttcattgtca tacttactat attcggatat attgctaaaa ttttcacaaa    180

cagaaataac tgcaccaata atgccattgg attgtgcaaa cgcatcaaat gttcaggctg    240

tgaaccgttc tgcagcaaaa ggggtgacac ttcttctccc agaaccggag tggacatacc    300

ctcgtttatc ttgcccgggc tcaacctttc agaaagcact cctaattagc ccccatagat    360

tcggagaaac caaaggaaac tcagctccct tgataataag ggaacctttt attgcttgtg    420

gaccaacgga atgcaaacac tttgctctaa cccattatgc agctcaacca gggggatact    480

acaatggaac aagagaagac agaaacaagc tgaggcatct aatttcagtc aaattgggca    540

aaatcccaac agtagaaaac tccattttcc atatggcagc ttggagcggg tccgcatgcc    600

atgatggtaa agaatggaca tatatcggag ttgatggccc cgacagtaat gcattactca    660

aaataaaata tggagaagca tatactgaca cataccattc ctatgcaaaa aacatcctaa    720

ggacacaaga aagtgcctgc aattgcatcg ggggagattg ttatcttatg ataactgatg    780

gcccagcttc agggattagt gaatgcagat tccttaagat tcgagagggc cgaataataa    840

aagaaatatt tccaacagga agagtaaaac atactgagga atgcacatgc ggatttgcca    900

gcaacaaaac catagaatgt gcttgtagag ataacagtta cacagcaaaa agaccctttg    960

tcaaattaaa tgtggagact gatacagcgg aaataagatt gatgtgcaca gagacttatt   1020

tggacacccc cagaccaaat gatggaagca taacagggcc ttgcgaatct gatggggaca   1080

aagggagtgg aggcatcaag ggaggatttg ttcatcaaag aatggcatcc aagattggaa   1140

ggtggtactc tcgaacgatg tctaaaacta aaagaatggg gatgggactg tatgtaaagt   1200

atgatggaga cccatggact gacagtgaag cccttgctct tagtggagta atggtttcga   1260

tggaagaacc tggttggtat tcctttggct tcgaaataaa agataagaaa tgtgatgtcc   1320

cctgtattgg gatagaaatg gtacatgatg gtgggaaaac gacttggcac tcagcagcaa   1380

cagccattta ctgtttaatg ggctcaggac aactgctgtg ggacactgtc acaggtgttg   1440

atatggctct gtaatggagg aatggttgag tctgttctaa accctttgtt cctattttgt   1500

ttgaacaatt gtccttactg agcttaattg tttctgaaaa atgctcttgt tactact      1557


<210>  12
<211>  466
<212>  PRT
<213>  Influenza B virus

<400>  12

Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser Gly 
1               5                   10                  15      


Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu Leu 
            20                  25                  30          


Tyr Ser Asp Ile Leu Leu Lys Phe Ser Gln Thr Glu Ile Thr Ala Pro 
        35                  40                  45              


Ile Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn 
    50                  55                  60                  


Arg Ser Ala Ala Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu Trp 
65                  70                  75                  80  


Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu 
                85                  90                  95      


Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro 
            100                 105                 110         


Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Thr Glu Cys Lys 
        115                 120                 125             


His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn 
    130                 135                 140                 


Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys 
145                 150                 155                 160 


Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala Ala 
                165                 170                 175     


Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile Gly 
            180                 185                 190         


Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly Glu 
        195                 200                 205             


Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Lys Asn Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met Ile 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Ser Gly Ile Ser Glu Cys Arg Phe Leu Lys Ile 
                245                 250                 255     


Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val Lys 
            260                 265                 270         


His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu 
        275                 280                 285             


Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys 
    290                 295                 300                 


Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Glu 
305                 310                 315                 320 


Thr Tyr Leu Asp Thr Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly Pro 
                325                 330                 335     


Cys Glu Ser Asp Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe 
            340                 345                 350         


Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr 
        355                 360                 365             


Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Asp 
    370                 375                 380                 


Gly Asp Pro Trp Thr Asp Ser Glu Ala Leu Ala Leu Ser Gly Val Met 
385                 390                 395                 400 


Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys 
                405                 410                 415     


Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp 
            420                 425                 430         


Gly Gly Lys Thr Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu 
        435                 440                 445             


Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp Met 
    450                 455                 460                 


Ala Leu 
465     


<210>  13
<211>  1763
<212>  DNA
<213>  Influenza A virus

<400>  13
agcaaaagca ggggataatt ctattaacca tgaagactat cattgctttg agctacattc     60

tatgtctggt tttcgctcaa aaacttcccg gaaatgacaa cagcacggca acgctgtgcc    120

ttgggcacca tgcagtacca aacggaacga tagtgaaaac aatcacgaat gaccaaattg    180

aagttactaa tgctactgag ctggttcaga gttcctcaac aggtggaata tgcgacagtc    240

ctcatcagat ccttgatgga gaaaactgca cactaataga tgctctattg ggagaccctc    300

agtgtgatgg cttccaaaat aagaaatggg acctttttgt tgaacgcagc aaagcctaca    360

gcaactgtta cccttatgat gtgccggatt atgcctccct taggtcacta gttgcctcat    420

ccggcacact ggagtttaac gatgaaagct tcaattggac tggagtcact caaaatggaa    480

caagctcttc ttgcaaaagg agatctaata acagtttctt tagtagattg aattggttga    540

cccacttaaa attcaaatac ccagcattga acgtgactat gccaaacaat gaaaaatttg    600

acaaattgta catttggggg gttcaccacc cggttacgga caatgaccaa atcttcctgt    660

atgctcaagc atcaggaaga atcacagtct ctaccaaaag aagccaacaa actgtaatcc    720

cgaatatcgg atctagaccc agaataagga atatccccag cagaataagc atctattgga    780

caatagtaaa accgggagac atacttttga ttaacagcac agggaatcta attgctccta    840

ggggttactt caaaatacga agtgggaaaa gctcaataat gagatcagat gcacccattg    900

gcaaatgcaa ttctgaatgc atcactccaa atggaagcat tcccaatgac aaaccatttc    960

aaaatgtaaa caggatcaca tatggggcct gtcccagata tgttaagcaa aacactctga   1020

aattggcaac agggatgcga aatgtaccag agaaacaaac tagaggcata tttggcgcaa   1080

tcgcgggttt catagaaaat ggttgggagg gaatggtgga tggttggtac ggtttcaggc   1140

atcaaaattc tgagggaata ggacaagcag cagatctcaa aagcactcaa gcagcaatca   1200

atcaaatcaa tgggaagctg aataggttga tcgggaaaac caacgagaaa ttccatcaga   1260

ttgaaaaaga attctcagaa gtagaaggga gaattcagga cctcgagaaa tatgttgagg   1320

acactaaaat agatctctgg tcatacaacg cggagcttct tgttgccctg gagaaccaac   1380

atacaattga tctaactgac tcagaaatga acaaactgtt tgaaagaaca aagaagcaac   1440

tgagggaaaa tgctgaggat atgggcaatg gttgtttcaa aatataccac aaatgtgaca   1500

atgcctgcat aggatcaatc agaaatggaa cttatgacca tgatgtatac agagatgaag   1560

cattaaacaa ccggttccag atcaaaggcg ttgagctgaa gtcaggatac aaagattgga   1620

tcctatggat ttcctttgcc atatcatgtt ttttgctttg tgttgctttg ttggggttca   1680

tcatgtgggc ctgccaaaaa ggcaacatta ggtgcaacat ttgcatttga gtgcattaat   1740

taaaaacacc cttgtttcta cta                                           1763


<210>  14
<211>  566
<212>  PRT
<213>  Influenza A virus

<400>  14

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asp Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Val Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  15
<211>  1445
<212>  DNA
<213>  Influenza A virus

<400>  15
agcaaaagca ggagtaaaga tgaatccaaa tcaaaagata ataacgattg gctctgtttc     60

tctcaccatt tccacaatat gcttcttcat gcaaattgcc atcttgataa ctactgtaac    120

attgcatttc aagcaatatg aattcaactc ccccccaaac aaccaagtga tgctgtgtga    180

accaacaata atagaaagaa acataacaga gatagtgtat ctgaccaaca ccaccataga    240

gaaggaaata tgccccaaac tagcagaata cagaaattgg tcaaagccgc aatgtaacat    300

tacaggattt gcaccttttt ctaaggacaa ttcgattagg ctttccgctg gtggggacat    360

ctgggtgaca agagaacctt atgtgtcatg cgatcctgac aaatgttatc aatttgccct    420

tgggcaggga acaacactaa acaacgtgca ttcaaatgac acagtacatg ataggacccc    480

ttatcggacc ctattgatga atgagttagg tgttccattt catctgggga ccaagcaagt    540

gtgcatagca tggtccagct caagttgtca cgatggaaaa gcatggctgc atgtttgtgt    600

aacgggggat gataaaaatg caactgctag cttcatttac aatgggaggc ttgtagatag    660

tattgtttca tggtccaaag aaatcctcag gacccaggag tcagaatgcg tttgtatcaa    720

tggaacttgt acagtagtaa tgactgatgg gagtgcttca ggaaaagctg atactaaaat    780

actattcatt gaggagggga aaatcgttca tactagcaca ttgtcaggaa gtgctcagca    840

tgtcgaggag tgctcctgct atcctcgata tcttggtgtc agatgtgtct gcagagacaa    900

ctggaaaggc tccaataggc ccatagtaga tataaacata aaggattata gcattgtttc    960

cagttatgtg tgctcaggac ttgttggaga cacacccaga aaaaacgaca gctccagcag   1020

tagccattgc ttggatccta acaatgaaga aggtggtcat ggagtgaaag gctgggcctt   1080

tgatgatgga aatgacgtgt ggatgggaag aacgatcagc gagaagttac gctcaggata   1140

tgaaaccttc aaagtcattg aaggctggtc caaccctaat tccaaattgc agataaatag   1200

gcaagtcata gttgacagag gtaataggtc cggttattct ggtattttct ctgttgaagg   1260

caaaagctgc atcaatcggt gcttttatgt ggagttgata aggggaagaa aagaggaaac   1320

tgaagtcttg tggacctcaa acagtattgt tgtgttttgt ggcacctcag gtacatatgg   1380

aacaggctca tggcctgatg gggcggacat caatctcatg cctatataag ctttcgcaat   1440

tttag                                                               1445


<210>  16
<211>  469
<212>  PRT
<213>  Influenza A virus

<400>  16

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Leu Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asn Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asp Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Val Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Ile Val Ser Trp Ser Lys Glu Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Thr Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Leu Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu 
        355                 360                 365             


Lys Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Asn Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asn Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile 
    450                 455                 460                 


Asn Leu Met Pro Ile 
465                 


<210>  17
<211>  1769
<212>  DNA
<213>  Influenza A virus

<400>  17
agcaggggaa aataaaaaca accaaaatga aagtaaaact actggtcctg ttatgcacat     60

ttacagctac atatgcagac acaatatgta taggctacca tgccaacaac tcaaccgaca    120

ctgttgacac agtacttgag aagaatgtga cagtgacaca ctctgtcaac ctgcttgagg    180

acagtcacaa tggaaaatta tgtctattaa aaggaatagc cccactacaa ttgggtaatt    240

gcagcgttgc cggatggatc ttaggaaacc cagaatgcga attactgatt tccagggaat    300

catggtccta cattgtagaa aaaccaaatc ctgagaatgg aacatgttac ccagggcatt    360

tcgccgacta tgaggaactg agggagcaat tgagttcagt atcttcattt gagagattcg    420

aaatattccc caaagaaagc tcatggccca accacaccac aaccggagta tcagcatcat    480

gctcccataa tggggaaagc agtttttaca aaaatttgct atggctgacg gggaagaatg    540

gtttgtaccc aaacctgagc aagtcctatg caaacaacaa agagaaagaa gtccttgtac    600

tatggggtgt tcatcacccg cctaacatag gtgaccaaag ggctctctat catacagaaa    660

atgcttatgt ctctgtagtg tcttcacatt atagcagaaa attcacccca gaaatagcca    720

aaagacccaa agtaagagat cgagaaggaa gaatcaacta ctactggact ctacttgaac    780

ccggggatac aataatattt gaggcaaatg gaaatctaat agcgccaaga tatgctttcg    840

cactgagtag aggctttgga tcaggaatca tcaactcaaa tgcaccaatg gatgaatgtg    900

atgcgaagtg ccaaacacct cagggagcta taaacagcag tcttcctttc cagaatgtac    960

accctgtcac aataggagag tgtccaaagt atgtcaggag tgcaaaatta aggatggtta   1020

caggactaag gaacatccca tccattcaat ccagaggttt gtttggagcc attgccggtt   1080

tcattgaagg ggggtggact ggaatggtag atggttggta tggttatcat catcagaatg   1140

agcaaggatc tggctatgct gcagatcaaa aaagcacaca aaatgccatt aatgggatta   1200

caaacaaggt gaattctgta attgagaaaa tgaacactca attcacagct gtgggcaaag   1260

aattcaacaa attggaaaga aggatggaaa acttaaataa aaaagttgat gatgggttta   1320

tagacatttg gacatataat gcagaattgt tggttctact ggaaaatgaa aggactttgg   1380

atttccatga ctccaatgtg aagaatctgt atgagaaagt aaaaagccaa ttaaagaata   1440

atgccaaaga aataggaaat gggtgttttg aattctatca caagtgtaac gatgaatgca   1500

tggagagtgt aaaaaatgga acttatgact atccaaaata ttccgaagaa tcaaagttaa   1560

acagggagaa aattgatgga gtgaaattgg aatcaatggg agtctatcag attctggcga   1620

tctactcaac agtcgccagt tctctggttc ttttggtctc cctgggggca atcagcttct   1680

ggatgtgttc caatgggtct ttgcagtgta gaatatgcat ctaagaccag aatttcagaa   1740

atataaggaa aaacaccctt gtttctact                                     1769


<210>  18
<211>  565
<212>  PRT
<213>  Influenza A virus

<400>  18

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Arg Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Thr Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
145                 150                 155                 160 


Tyr Lys Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Arg Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  19
<211>  1463
<212>  DNA
<213>  Influenza A virus

<400>  19
agcaaaagca ggagtttaaa atgaacccaa atcaaaaaat aataaccatt ggatcaatca     60

gtatagcaat cggaataatt agtctaatat tgcaaatagg aaatattatt tcaatatggg    120

ctagtcactc aatccaaact ggaagtcaaa accacactgg aatatgcaac caaagaatca    180

tcacatatga aaacagcacc tgggtgaata acacatatgt taatattaac aacaccaatg    240

ttgttgctga aaaggacaaa acttcagtga cattggccgg caattcatct ctttgttcta    300

tcagtgggtg ggctatatac acaaaagaca acagcataag aattggctcc aaaggagatg    360

tttttgtcat aagagaacct ttcatatcat gttctcactt ggaatgcaga accttttttc    420

tgacccaagg tgctctatta aatgacaaac attcaaatgg gaccgtaaag gacagaagtc    480

cttatagggc cttaatgagc tgtcctctag gtgaagctcc gtccccatac aattcaaggt    540

ttgaatcagt tgcatggtca gcaagcgcat gccatgatgg catgggctgg ttaacaatcg    600

gaatttctgg tccagacaat ggagctgtgg ctgtactaaa atacaacgga ataataactg    660

aaaccataaa aagttggaaa aagcgaatat taagaacaca agagtctgaa tgtgtctgta    720

tgaacgggtc atgtttcacc ataatgaccg atggcccgag taatggggcc gcctcgtaca    780

aaattttcaa gatcgaaaag gggaaggtta ccaaaacaat agagttgaat gcacccaatt    840

ttcattatga ggaatgttcc tgttacccag acactggcac agtgatgtgt gtatgcagag    900

acaactggca tggttcaaat cgaccttggg tgtcttttaa tcaaaacttg gattatcaaa    960

taggatacat ctgcagtgga gtgttcggtg acaatccgcg tcccaaagat ggggagggca   1020

gctgcaatcc agtgactgtt gatggagcag acggagtaaa agggttttca tacaaatatg   1080

gtaatggtgt ttggatagga aggaccaaaa gtaacagact tagaaagggg tttgagatga   1140

tttgggatcc taatggatgg acaaataccg acagtgattt ctcagtgaaa caggatgttg   1200

tagcaataac tgattggtca gggtacagcg gaagttttgt tcaacatcct gagttaacag   1260

gattggactg tataagacct tgcttctggg ttgagttagt cagagggctg cctagggaaa   1320

atacaacaat ctggactagt gggagcagca tttctttttg tggcgttaat agtggtactg   1380

caaactggtc ttggccagac ggtgctgagt tgccgttcac cattgacaag tagttcgttg   1440

aaaaaaaact ccttgtttct act                                           1463


<210>  20
<211>  470
<212>  PRT
<213>  Influenza A virus

<400>  20

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Ser Ile Ala 
1               5                   10                  15      


Ile Gly Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ala Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn Asn 
    50                  55                  60                  


Thr Tyr Val Asn Ile Asn Asn Thr Asn Val Val Ala Glu Lys Asp Lys 
65                  70                  75                  80  


Thr Ser Val Thr Leu Ala Gly Asn Ser Ser Leu Cys Ser Ile Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Thr Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser 
145                 150                 155                 160 


Cys Pro Leu Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Lys Lys Arg Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Val Cys Met Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asn Gly Ala Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Lys Ile Glu Lys Gly Lys Val Thr Lys Thr Ile Glu Leu Asn Ala Pro 
            260                 265                 270         


Asn Phe His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr Val 
        275                 280                 285             


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Lys Asp Gly Glu Gly Ser Cys Asn 
                325                 330                 335     


Pro Val Thr Val Asp Gly Ala Asp Gly Val Lys Gly Phe Ser Tyr Lys 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asn Thr Asp 
    370                 375                 380                 


Ser Asp Phe Ser Val Lys Gln Asp Val Val Ala Ile Thr Asp Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Val Arg Gly Leu Pro Arg 
            420                 425                 430         


Glu Asn Thr Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly 
        435                 440                 445             


Val Asn Ser Gly Thr Ala Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu 
    450                 455                 460                 


Pro Phe Thr Ile Asp Lys 
465                 470 


<210>  21
<211>  1883
<212>  DNA
<213>  Influenza B virus

<400>  21
gcagaagcag agcattttct aatatccaca aaatgaaggc aataattgta ctactcatgg     60

tagtaacatc caatgcagat cgaatctgca ctgggataac atcgtcaaac tcaccacatg    120

ttgtcaaaac tgctactcaa ggggaggtca atgtgactgg tgtaatacca ctgacaacaa    180

cacccaccaa atctcatttt gcaaatctca aaggaacaga aaccagaggg aaactatgcc    240

caaaatgcct caactgcaca gatctggacg tggccttggg cagaccaaaa tgcacgggga    300

acataccctc ggcaagagtt tcaatactcc atgaagtcag acctgttaca tctgggtgct    360

ttcctataat gcacgacaga acaaaaatta gacagctgcc taaccttctc agaggatacg    420

aacatatcag gttatcaact cataacgtta tcaatgcaga aaatgcacca ggaggaccct    480

acaaaattgg aacctcaggg tcttgcccta acgttaccaa tggaaacgga tttttcgcaa    540

caatggcttg ggccgtccca aaaaacgaca acaacaaaac agcaacaaat tcattaacaa    600

tagaagtacc atacatttgt acagaaggag aagaccaaat taccgtttgg gggttccact    660

ctgatagcga aacccaaatg gcaaagctct atggggactc aaagccccag aagttcacct    720

catctgccaa cggagtgacc acacattacg tttcacagat tggtggcttc ccaaatcaaa    780

cagaagacgg aggactacca caaagtggta gaattgttgt tgattacatg gtgcaaaaat    840

ctgggaaaac aggaacaatt acctatcaaa gaggtatttt attgcctcaa aaagtgtggt    900

gcgcaagtgg caggagcaag gtaataaaag gatccttgcc tttaattgga gaagcagatt    960

gcctccacga aaaatacggt ggattaaaca aaagcaagcc ttactacaca ggggaacatg   1020

caaaggccat aggaaattgc ccaatatggg tgaaaacacc cttgaagctg gccaatggaa   1080

ccaaatatag acctcctgca aaactattaa aggaaagggg tttcttcgga gctattgctg   1140

gtttcttaga aggaggatgg gaaggaatga ttgcaggttg gcacggatac acatcccatg   1200

gggcacatgg agtagcggtg gcagcagacc ttaagagcac tcaagaggcc ataaacaaga   1260

taacaaaaaa tctcaactct ttgagtgagc tggaagtaaa gaatcttcaa agactaagcg   1320

gtgccatgga tgaactccac aacgaaatac tagaactaga cgagaaagtg gatgatctca   1380

gagctgatac aataagctca caaatagaac tcgcagtcct gctttccaat gaaggaataa   1440

taaacagtga agatgagcat ctcttggcgc ttgaaagaaa gctgaagaaa atgctgggcc   1500

cctctgctgt agagataggg aatggatgct ttgaaaccaa acacaagtgc aaccagacct   1560

gtctcgacag aatagctgct ggtacctttg atgcaggaga attttctctc cccacttttg   1620

attcactgaa tattactgct gcatctttaa atgacgatgg attggataat catactatac   1680

tgctttacta ctcaactgct gcctccagtt tggctgtaac attgatgata gctatctttg   1740

ttgtttatat ggtctccaga gacaatgttt cttgctccat ctgtctataa ggaaagttaa   1800

accctgtatt ttcctttatt gtagtgcttg tttgcttgtt accattacaa aaaacgttat   1860

tgaaaaatgc tcttgttact act                                           1883


<210>  22
<211>  585
<212>  PRT
<213>  Influenza B virus

<400>  22

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Ser Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  23
<211>  1536
<212>  DNA
<213>  Influenza B virus

<400>  23
agcagaagca gagcatcttc tcaaaactga agcaaatagg ccaaaaatga acaatgctac     60

cttcaactat acaaacgtta accctatttc tcacatcagg gggagtatta ttatcactat    120

atgtgtcagc ttcattgtca tacttactat attcggatat attgctaaaa ttcccatcaa    180

cagaaattac tgcaccaaca atgccattgg attgtgcaaa cgcatcaaat gttcaggctg    240

tgaaccgttc tgcaacaaaa ggggtgacac ttcttctccc agaaccggag tggacatacc    300

cgcgtttatc ttgcccgggc tcaacctttc agaaagcact cctaattagc cctcatagat    360

tcggagaaac caaaggaaac tcagctccct tgataataag ggaacctttt attgcttgtg    420

gaccaaagga atgcaaacac tttgctctaa cccactatgc agcccaacca gggggatact    480

acaatggaac aagaggagac agaaacaagc tgaggcatct aatttcagtc aaattgggca    540

aaatcccaac agtagaaaac tccattttcc acatggcagc atggagcggg tccgcatgcc    600

atgatggtaa ggaatggaca tatatcggag ttgatggccc tgacaataat gcattgctca    660

aaataaaata tggagaagca tatactgaca cataccattc ctatgcaaac aacatcctaa    720

gaacacaaga aagtgcctgc aattgcatcg ggggaaattg ttatcttatg ataactgatg    780

gctcagcttc aggtgttagt gaatgcagat ttcttaagat tcgagagggc cgaataataa    840

aagaaatatt tccaacagga agaataaaac atactgaaga atgcacatgc ggatttgcta    900

gcaataaaac catagaatgt gcctgtagag ataacagtta cacagcaaaa agaccctttg    960

tcaaattaaa cgtggagact gatacagcag aaataagatt gatgtgcaca gagacttatt   1020

tggacacccc cagaccagat gatggaagca taacagggcc ttgtgaatct aatggggaca   1080

aagggagtgg aggcatcaag ggaggatttg tccatcaaag aatggcatcc aagattggaa   1140

ggtggtactc tcgaacgatg tctaaaacta aaaggatggg gatggggctg tatgtcaagt   1200

atgatggaga cccatgggct gacagtgatg cccttgcttt tagtggagta atggtttcaa   1260

tggaagaacc tggttggtac tcctttggct tcgaaataaa agacaagaaa tgtgatgtcc   1320

cctgtattgg gatagagatg gtacatgatg gtggaaaaga gacttggcac tcagcagcta   1380

cagccattta ctgtttaatg ggctcaggac agctgctgtg ggacactgtc acaggtgtta   1440

atatggctct gtaatggagg aatggttgag tctgttctaa accctttgtt cctattttgt   1500

ttgaacaatt gtccttactg aacttaattg tttctg                             1536


<210>  24
<211>  466
<212>  PRT
<213>  influenza B virus

<400>  24

Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser Gly 
1               5                   10                  15      


Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu Leu 
            20                  25                  30          


Tyr Ser Asp Ile Leu Leu Lys Phe Pro Ser Thr Glu Ile Thr Ala Pro 
        35                  40                  45              


Thr Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn 
    50                  55                  60                  


Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu Trp 
65                  70                  75                  80  


Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu 
                85                  90                  95      


Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro 
            100                 105                 110         


Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys Lys 
        115                 120                 125             


His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn 
    130                 135                 140                 


Gly Thr Arg Gly Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys 
145                 150                 155                 160 


Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala Ala 
                165                 170                 175     


Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile Gly 
            180                 185                 190         


Val Asp Gly Pro Asp Asn Asn Ala Leu Leu Lys Ile Lys Tyr Gly Glu 
        195                 200                 205             


Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met Ile 
225                 230                 235                 240 


Thr Asp Gly Ser Ala Ser Gly Val Ser Glu Cys Arg Phe Leu Lys Ile 
                245                 250                 255     


Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Ile Lys 
            260                 265                 270         


His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu 
        275                 280                 285             


Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys 
    290                 295                 300                 


Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Glu 
305                 310                 315                 320 


Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly Pro 
                325                 330                 335     


Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe 
            340                 345                 350         


Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr 
        355                 360                 365             


Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Asp 
    370                 375                 380                 


Gly Asp Pro Trp Ala Asp Ser Asp Ala Leu Ala Phe Ser Gly Val Met 
385                 390                 395                 400 


Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys 
                405                 410                 415     


Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp 
            420                 425                 430         


Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu 
        435                 440                 445             


Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn Met 
    450                 455                 460                 


Ala Leu 
465     


<210>  25
<211>  1881
<212>  DNA
<213>  Influenza B virus

<400>  25
gaagcagagc attttctaat atccacaaaa tgaaggcaat aattgtacta ctcatggtag     60

taacatccaa tgcagatcga atctgcactg ggataacatc gtcaaactca ccacatgtcg    120

tcaaaactgc tactcaaggg gaggtcaatg tgactggtgt aataccactg acaacaacac    180

ccaccaaatc tcattttgca aatctcaaag gaacagaaac cagggggaaa ctatgcccaa    240

aatgcctcaa ctgcacagat ctggacgtag ccttgggcag accaaaatgc acggggaaaa    300

taccctcggc aagagtttca atactccatg aagtcagacc tgttacatct gggtgctttc    360

ctataatgca cgacagaaca aaaattagac agctgcctaa ccttctccga ggatacgaac    420

atatcaggtt atcaacccat aacgttatca atgcagaaaa tgcaccagga ggaccctaca    480

aaattggaac ctcagggtct tgccctaaca ttaccaatgg aaacggattt ttcgcaacaa    540

tggcttgggc cgtcccaaaa aacgacaaaa acaaaacagc aacaaatcca ttaacaatag    600

aagtaccata catttgtaca gaaggagaag accaaattac cgtttggggg ttccactctg    660

acgacgagac ccaaatggca aagctctatg gggactcaaa gccccagaag ttcacctcat    720

ctgccaacgg agtgaccaca cattacgttt cacagattgg tggcttccca aatcaaacag    780

aagacggagg actaccacaa agtggtagaa ttgttgttga ttacatggtg caaaaatctg    840

ggaaaacagg aacaattacc tatcaaaggg gtattttatt gcctcaaaag gtgtggtgcg    900

caagtggcag gagcaaggta ataaaaggat ccttgccttt aattggagaa gcagattgcc    960

tccacgaaaa atacggtgga ttaaacaaaa gcaagcctta ctacacaggg gaacatgcaa   1020

aggccatagg aaattgccca atatgggtga aaacaccctt gaagctggcc aatggaacca   1080

aatatagacc tcctgcaaaa ctattaaagg aaaggggttt cttcggagct attgctggtt   1140

tcttagaagg aggatgggaa ggaatgattg caggttggca cggatacaca tcccatgggg   1200

cacatggagt agcggtggca gcagacctta agagcactca agaggccata aacaagataa   1260

caaaaaatct caactctttg agtgagctgg aagtaaagaa tcttcaaaga ctaagcggtg   1320

ccatggatga actccacaac gaaatactag aactagatga gaaagtggat gatctcagag   1380

ctgatacaat aagctcacaa atagaactcg cagtcctgct ttccaatgaa ggaataataa   1440

acagtgaaga tgaacatctc ttggcgcttg aaagaaagct gaagaaaatg ctgggcccct   1500

ctgctgtaga gatagggaat ggatgctttg aaaccaaaca caagtgcaac cagacctgtc   1560

tcgacagaat agctgctggt acctttgatg caggagaatt ttctctcccc acctttgatt   1620

cactgaatat tactgctgca tctttaaatg acgatggatt ggataatcat actatactgc   1680

tttactactc aactgctgcc tccagtttgg ctgtaacact gatgatagct atctttgttg   1740

tttatatggt ctccagagac aatgtttctt gctccatctg tctataaggg aagttaagcc   1800

ctgtattttc ctttattgta gtgcttgttt acttgttgtc attacaaaga aacgttattg   1860

aaaaatgctc ttgttactac t                                             1881


<210>  26
<211>  585
<212>  PRT
<213>  Influenza B virus

<400>  26

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asp Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  27
<211>  1557
<212>  DNA
<213>  Influenza B virus

<400>  27
agcagaagca gagcatcttc tcaaaactga agcaaatagg ccaaaaatga acaatgctac     60

cttcaactat acaaacgtta accctatttc tcacatcagg gggagtatta ttatcactat    120

atgtgtcagc ttcattatca tacttactat attcggatat attgctaaaa ttctcaccaa    180

cagaaataac tgcaccaaca atgccattgg attgtgcaaa cgcatcaaat gttcaggctg    240

tgaaccgttc tgcaacaaaa ggggtgacac ttcttctccc agaaccggag tggacatacc    300

cgcgtttatc ttgcccgggc tcaacctttc agaaagcact cctaattagc cctcatagat    360

tcggagaaac caaaggaaac tcagctccct tgataataag ggaacctttt attgcttgtg    420

gaccaaatga atgcaaacac tttgctctaa cccattatgc agcccaacca gggggatact    480

acaatggaac aagaggagac agaaacaagc tgaggcatct aatttcagtc aaattgggca    540

aaatcccaac agtagaaaac tccattttcc acatggcagc atggagcggg tccgcgtgcc    600

atgatggtaa ggaatggaca tatatcggag ttgatggccc tgacaataat gcattgctca    660

aagtaaaata tggagaagca tatactgaca cataccattc ctatgcaaac aaaatcctaa    720

gaacacaaga aagtgcctgc aattgcatcg ggggaaattg ttatcttatg ataactgatg    780

gctcagcttc aggtgttagt gaatgcagat ttcttaagat tcgagagggc cgaataataa    840

aagaaatatt tccaacagga agagtaaaac acactgagga atgcacatgc ggatttgcca    900

gcaataaaac catagaatgt gcctgtagag ataacagtta cacagcaaaa agaccttttg    960

tcaaattaaa cgtggagact gatacagcag aaataagatt gatgtgcaca gatacttatt   1020

tggacacccc cagaccaaac gatggaagca taacaggccc ttgtgaatct aatggggaca   1080

aagggagtgg aggcatcaag ggaggatttg ttcatcaaag aatggaatcc aagattggaa   1140

ggtggtactc tcgaacgatg tctaaaactg aaaggatggg gatgggactg tatgtcaagt   1200

atgatggaga cccatgggct gacagtgatg ccctagcttt tagtggagta atggtttcaa   1260

tgaaagaacc tggttggtac tcctttggct tcgaaataaa agataagaaa tgcgatgtcc   1320

cctgtattgg gatagagatg gtacatgatg gtggaaaaga gacttggcac tcagcagcaa   1380

cagccattta ctgtttaatg ggctcaggac agctgctgtg ggacactgtc acaggtgttg   1440

acatggctct gtaatggagg aatggttgag tctgttctaa accctttgtt cctgttttgt   1500

ttgaacaatt gtccttacta aacttaattg tttctgaaaa atgctcttgt tactact      1557


<210>  28
<211>  466
<212>  PRT
<213>  Influenza B virus

<400>  28

Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser Gly 
1               5                   10                  15      


Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu Leu 
            20                  25                  30          


Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Glu Ile Thr Ala Pro 
        35                  40                  45              


Thr Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn 
    50                  55                  60                  


Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu Trp 
65                  70                  75                  80  


Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu 
                85                  90                  95      


Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro 
            100                 105                 110         


Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Asn Glu Cys Lys 
        115                 120                 125             


His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn 
    130                 135                 140                 


Gly Thr Arg Gly Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys 
145                 150                 155                 160 


Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala Ala 
                165                 170                 175     


Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile Gly 
            180                 185                 190         


Val Asp Gly Pro Asp Asn Asn Ala Leu Leu Lys Val Lys Tyr Gly Glu 
        195                 200                 205             


Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Lys Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met Ile 
225                 230                 235                 240 


Thr Asp Gly Ser Ala Ser Gly Val Ser Glu Cys Arg Phe Leu Lys Ile 
                245                 250                 255     


Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val Lys 
            260                 265                 270         


His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu 
        275                 280                 285             


Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys 
    290                 295                 300                 


Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Asp 
305                 310                 315                 320 


Thr Tyr Leu Asp Thr Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly Pro 
                325                 330                 335     


Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe 
            340                 345                 350         


Val His Gln Arg Met Glu Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr 
        355                 360                 365             


Met Ser Lys Thr Glu Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Asp 
    370                 375                 380                 


Gly Asp Pro Trp Ala Asp Ser Asp Ala Leu Ala Phe Ser Gly Val Met 
385                 390                 395                 400 


Val Ser Met Lys Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys 
                405                 410                 415     


Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp 
            420                 425                 430         


Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu 
        435                 440                 445             


Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp Met 
    450                 455                 460                 


Ala Leu 
465     


