                         SEQUENCE LISTING

<110>  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
       Katz, Joseph
       Langaee, Taimour
 
<120>  METHODS AND KITS FOR DETECTING RISK FACTORS FOR DEVELOPMENT OF 
       JAW OSTEONECROSIS AND METHODS OF TREATMENT THEREOF

<130>  5853-731WO

<150>  US 61/078,680
<151>  2008-07-07

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = a or g

<400>  1
cattctcatc agtattttaa ttccagntat gttgtttcct tgataatttt ct               52


<210>  2
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or t

<400>  2
ttccccatat tccccaccca gcactcnacc tctttagctc ttcaggtctc ag               52


<210>  3
<211>  51
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N = a or g

<400>  3
tagggtcccg ccggtcaaga tggtcncccc ggacccccag gcccacctgg t                51


<210>  4
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or g

<400>  4
aycctcaggg ccccagcctg gagtggntga agaaactgtg agcacctcca ct               52


<210>  5
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or t

<400>  5
tggattccat atcccactgc caaaacngca tggttcagat tatcgctatt gc               52


<210>  6
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or g

<400>  6
gtggctactg gtgctgacgc ctggccngcc ggccgcggga ctatccacct gc               52


<210>  7
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or t

<400>  7
acatcatggg acagagaaat ccgatgnggt ttgcagttct tctctgccag ct               52


<210>  8
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or t

<400>  8
gatccggatc aggatgcaac atacttnggg gcttttaaag ttcgagatat ag               52


<210>  9
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or t

<400>  9
ctgctgcctt ccctgcccca gtacccncag gagaagattc caaagatgta gc               52


<210>  10
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or t

<400>  10
tggcctgctt gctgttctta cagggangga ggcaatggcg gccagcactt cc               52


<210>  11
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or t

<400>  11
cctggggtgc aggacgccgc gctgatngag gccatccagg accgcctgtc ca               52


<210>  12
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = a, c, g or t

<400>  12
gttccccaac tgttttgaat tctagtngca gaatggatga atctgtttgg cg               52


<210>  13
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = c or t

<400>  13
ggaataatca atgaagcatt caattcngtc atcttgctcc actctcccat tt               52


<210>  14
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = a or g

<400>  14
ctctggggct ggtagaattg ctatttntcc atgatcaaga gcaccactct ta               52


<210>  15
<211>  52
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = g or t

<400>  15
ccgccacccc acctgcccag ggaatgnggg cgggatgagg gctggacctc cc               52


<210>  16
<211>  113
<212>  PRT
<213>  homo sapiens

<400>  16

Met Ile Pro Ala Lys Asp Met Ala Lys Val Met Ile Val Met Leu Ala 
1               5                   10                  15      


Ile Cys Phe Leu Thr Lys Ser Asp Gly Lys Ser Val Lys Lys Arg Ser 
            20                  25                  30          


Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser 
        35                  40                  45              


Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn 
    50                  55                  60                  


Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser Gln 
65                  70                  75                  80  


Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu Lys 
                85                  90                  95      


Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys Ala 
            100                 105                 110         


Lys 
    


<210>  17
<211>  110
<212>  PRT
<213>  homo sapiens

<400>  17

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  18
<211>  233
<212>  PRT
<213>  homo sapiens

<400>  18

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  19
<211>  167
<212>  PRT
<213>  homo sapiens

<400>  19

Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  20
<211>  100
<212>  PRT
<213>  homo sapiens

<400>  20

Met Arg Ala Leu Thr Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Ile Ala Gly Gln Ala Gly Ala Lys Pro Ser Gly Ala Glu Ser Ser Lys 
            20                  25                  30          


Gly Ala Ala Phe Val Ser Lys Gln Glu Gly Ser Glu Val Val Lys Arg 
        35                  40                  45              


Pro Arg Arg Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro 
    50                  55                  60                  


Asp Pro Leu Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys 
65                  70                  75                  80  


Asp Glu Leu Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe 
                85                  90                  95      


Tyr Gly Pro Val 
            100 


<210>  21
<211>  372
<212>  PRT
<213>  homo sapiens

<400>  21

Glu Thr Phe Pro Pro Lys Tyr Leu His Tyr Asp Glu Glu Thr Ser His 
1               5                   10                  15      


Gln Leu Leu Cys Asp Lys Cys Pro Pro Gly Thr Tyr Leu Lys Gln His 
            20                  25                  30          


Cys Thr Ala Lys Trp Lys Thr Val Cys Ala Pro Cys Pro Asp His Tyr 
        35                  40                  45              


Tyr Thr Asp Ser Trp His Thr Ser Asp Glu Cys Leu Tyr Cys Ser Pro 
    50                  55                  60                  


Val Cys Lys Glu Leu Gln Tyr Val Lys Gln Glu Cys Asn Arg Thr His 
65                  70                  75                  80  


Asn Arg Val Cys Glu Cys Lys Glu Gly Arg Tyr Leu Glu Ile Glu Phe 
                85                  90                  95      


Cys Leu Lys His Arg Ser Cys Pro Pro Gly Phe Gly Val Val Gln Ala 
            100                 105                 110         


Gly Thr Pro Glu Arg Asn Thr Val Cys Lys Arg Cys Pro Asp Gly Phe 
        115                 120                 125             


Phe Ser Asn Glu Thr Ser Ser Lys Ala Pro Cys Arg Lys His Thr Asn 
    130                 135                 140                 


Cys Ser Val Phe Gly Leu Leu Leu Thr Gln Lys Gly Asn Ala Thr His 
145                 150                 155                 160 


Asp Asn Ile Cys Ser Gly Asn Ser Glu Ser Thr Gln Lys Cys Gly Ile 
                165                 170                 175     


Asp Val Thr Leu Cys Glu Glu Ala Phe Phe Arg Phe Ala Val Pro Thr 
            180                 185                 190         


Lys Phe Thr Pro Asn Trp Leu Ser Val Leu Val Asp Asn Leu Pro Gly 
        195                 200                 205             


Thr Lys Val Asn Ala Glu Ser Val Glu Arg Ile Lys Arg Gln His Ser 
    210                 215                 220                 


Ser Gln Glu Gln Thr Phe Gln Leu Leu Lys Leu Trp Lys His Gln Asn 
225                 230                 235                 240 


Lys Asp Gln Asp Ile Val Lys Lys Ile Ile Gln Asp Ile Asp Leu Cys 
                245                 250                 255     


Glu Asn Ser Val Gln Arg His Ile Gly His Ala Asn Leu Thr Phe Glu 
            260                 265                 270         


Gln Leu Arg Ser Leu Met Glu Ser Leu Pro Gly Lys Lys Val Gly Ala 
        275                 280                 285             


Glu Asp Ile Glu Lys Thr Ile Lys Ala Cys Lys Pro Ser Asp Gln Ile 
    290                 295                 300                 


Leu Lys Leu Leu Ser Leu Trp Arg Ile Lys Asn Gly Asp Gln Asp Thr 
305                 310                 315                 320 


Leu Lys Gly Leu Met His Ala Leu Lys His Ser Lys Thr Tyr His Phe 
                325                 330                 335     


Pro Lys Thr Val Thr Gln Ser Leu Lys Lys Thr Ile Arg Phe Leu His 
            340                 345                 350         


Ser Phe Thr Met Tyr Lys Leu Tyr Gln Lys Leu Phe Leu Glu Met Ile 
        355                 360                 365             


Gly Asn Gln Val 
    370         


<210>  22
<211>  273
<212>  PRT
<213>  homo sapiens

<400>  22

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Thr 
            20                  25                  30          


Leu Pro Ser Lys Ser Asn Glu Ser His Asp His Met Asp Asp Met Asp 
        35                  40                  45              


Asp Glu Asp Asp Asp Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser 
    50                  55                  60                  


Asn Asp Ser Asp Asp Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp 
65                  70                  75                  80  


Glu Ser His His Ser Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro 
                85                  90                  95      


Thr Asp Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val Pro Thr Val 
            100                 105                 110         


Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser 
        115                 120                 125             


Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr 
    130                 135                 140                 


Asp Glu Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala 
145                 150                 155                 160 


Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp 
                165                 170                 175     


Asp Ser Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln 
            180                 185                 190         


Ser Ala Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys 
        195                 200                 205             


Ala Asn Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu 
    210                 215                 220                 


Leu Ser Lys Val Ser Arg Glu Phe His Ser His Glu Phe His Ser His 
225                 230                 235                 240 


Glu Asp Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His 
                245                 250                 255     


Leu Lys Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val 
            260                 265                 270         


Asn 
    


<210>  23
<211>  212
<212>  PRT
<213>  homo sapiens

<400>  23

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


