                         SEQUENCE LISTING

<110>  SANOFI-AVENTIS
 
<120>  Antagonistes spcifiques du rcepteur FGF-R4

<130>  FR2008-072 PCT

<160>  117   

<170>  PatentIn version 3.3

<210>  1
<211>  1389
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(1389)

<400>  1
atg aac agg ctt act tcc tca ttg ctg ctg ctg att gtc cct gca tat       48
Met Asn Arg Leu Thr Ser Ser Leu Leu Leu Leu Ile Val Pro Ala Tyr         
1               5                   10                  15              

gtc ctg tcc cag gtt act ctg aaa gag tct ggc cct ggg ata ttg cag       96
Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln         
            20                  25                  30                  

ccc tcc cag acc ctc agt ctg act tgt tct ttc tct ggg ttt tca ctg      144
Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu         
        35                  40                  45                      

agc act tct ggt atg ggt gtg agc tgg att cgt cag cct tca gga aag      192
Ser Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys         
    50                  55                  60                          

ggt ctg gag tgg ctg gca cac att tac tgg gat gat gac aag cgc tat      240
Gly Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr         
65                  70                  75                  80          

aac cca tcc ctg aag agc cgg ctc aca atc tcc aag gat acc tcc agc      288
Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser         
                85                  90                  95              

aac cag gta ttc ctc aag atc acc agt gtg gac act gca gat act gcc      336
Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala         
            100                 105                 110                 

aca tac tac tgt gct cga gat tac tac gct agt agc ttt gac tac tgg      384
Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp         
        115                 120                 125                     

ggc caa ggc acc act ctc aca gtc tcc tca gcc aaa acg aca ccc cca      432
Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro         
    130                 135                 140                         

tct gtc tat cca ctg gcc cct gga tct gct gcc caa act aac tcc atg      480
Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met         
145                 150                 155                 160         

gtg acc ctg gga tgc ctg gtc aag ggc tat ttc cct gag cca gtg aca      528
Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr         
                165                 170                 175             

gtg acc tgg aac tct gga tcc ctg tcc agc ggt gtg cac acc ttc cca      576
Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro         
            180                 185                 190                 

gct gtc ctg cag tct gac ctc tac act ctg agc agc tca gtg act gtc      624
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val         
        195                 200                 205                     

ccc tcc agc acc tgg ccc agc gag acc gtc acc tgc aac gtt gcc cac      672
Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His         
    210                 215                 220                         

ccg gcc agc agc acc aag gtg gac aag aaa att gtg ccc agg gat tgt      720
Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys         
225                 230                 235                 240         

ggt tgt aag cct tgc ata tgt aca gtc cca gaa gta tca tct gtc ttc      768
Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe         
                245                 250                 255             

atc ttc ccc cca aag ccc aag gat gtg ctc acc att act ctg act cct      816
Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro         
            260                 265                 270                 

aag gtc acg tgt gtt gtg gta gac atc agc aag gat gat ccc gag gtc      864
Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val         
        275                 280                 285                     

cag ttc agc tgg ttt gta gat gat gtg gag gtg cac aca gct cag acg      912
Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr         
    290                 295                 300                         

caa ccc cgg gag gag cag ttc aac agc act ttc cgc tca gtc agt gaa      960
Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu         
305                 310                 315                 320         

ctt ccc atc atg cac cag gac tgg ctc aat ggc aag gag ttc aaa tgc     1008
Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys         
                325                 330                 335             

agg gtc aac agt gca gct ttc cct gcc ccc atc gag aaa acc atc tcc     1056
Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser         
            340                 345                 350                 

aaa acc aaa ggc aga ccg aag gct cca cag gtg tac acc att cca cct     1104
Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro         
        355                 360                 365                     

ccc aag gag cag atg gcc aag gat aaa gtc agt ctg acc tgc atg ata     1152
Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile         
    370                 375                 380                         

aca gac ttc ttc cct gaa gac att act gtg gag tgg cag tgg aat ggg     1200
Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly         
385                 390                 395                 400         

cag cca gcg gag aac tac aag aac act cag ccc atc atg gac aca gat     1248
Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp         
                405                 410                 415             

ggc tct tac ttc gtc tac agc aag ctc aat gtg cag aag agc aac tgg     1296
Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp         
            420                 425                 430                 

gag gca gga aat act ttc acc tgc tct gtg tta cat gag ggc ctg cac     1344
Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His         
        435                 440                 445                     

aac cac cat act gag aag agc ctc tcc cac tct cct ggt aag tga         1389
Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys                 
    450                 455                 460                         


<210>  2
<211>  462
<212>  PRT
<213>  Mus sp.

<400>  2

Met Asn Arg Leu Thr Ser Ser Leu Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235                 240 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            260                 265                 270         


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        355                 360                 365             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
385                 390                 395                 400 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
                405                 410                 415     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            420                 425                 430         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460         


<210>  3
<211>  705
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(705)

<400>  3
atg gtt ttc aca cct cag att ctt gga ctt atg ctt ttc tgg att tca       48
Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser         
1               5                   10                  15              

gcc tcc aga ggt gat att gtg cta act cag tct cca gcc acc ctg tct       96
Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser         
            20                  25                  30                  

gtg act cca gga gat aga gtc agt ctt tcc tgc agg gcc agt caa agt      144
Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser         
        35                  40                  45                      

att agc aac tac cta cac tgg tat caa caa aaa tca cat gag tct cca      192
Ile Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro         
    50                  55                  60                          

agg ctt ctc atc aag tat gct tcc cag tcc atc tct ggg atc ccc tcc      240
Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser         
65                  70                  75                  80          

agg ttc agt ggc agt gga tca ggg aca gat ttc att ctc agt ttc aac      288
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn         
                85                  90                  95              

agt gtg gag act gaa gat ttt gga atg tat ttc tgt caa cag agt aac      336
Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn         
            100                 105                 110                 

agc tgg cct ttc acg ttc ggc tcg ggg aca aaa ttg gaa ata aaa cgg      384
Ser Trp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg         
        115                 120                 125                     

gct gat gct gca cca act gta tcc atc ttc cca cca tcc agt gag cag      432
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln         
    130                 135                 140                         

tta aca tct gga ggt gcc tca gtc gtg tgc ttc ttg aac aac ttc tac      480
Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr         
145                 150                 155                 160         

ccc aaa gac atc aat gtc aag tgg aag att gat ggc agt gaa cga caa      528
Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln         
                165                 170                 175             

aat ggc gtc ctg aac agt tgg act gat cag gac agc aaa gac agc acc      576
Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr         
            180                 185                 190                 

tac agc atg agc agc acc ctc acg ttg acc aag gac gag tat gaa cga      624
Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg         
        195                 200                 205                     

cat aac agc tat acc tgt gag gcc act cac aag aca tca act tca ccc      672
His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro         
    210                 215                 220                         

att gtc aag agc ttc aac agg aat gag tgt taa                          705
Ile Val Lys Ser Phe Asn Arg Asn Glu Cys                                 
225                 230                                                 


<210>  4
<211>  234
<212>  PRT
<213>  Mus sp.

<400>  4

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn 
            100                 105                 110         


Ser Trp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  5
<211>  442
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (29)..(442)

<400>  5
tgaaggagta gaaaactagt gtgcagat atg aac agg ctt act tcc tca ttg        52
                               Met Asn Arg Leu Thr Ser Ser Leu          
                               1               5                        

ctg ctg ctg att gtc cct gca tat gtc ctg tcc cag gtt act ctg aaa      100
Leu Leu Leu Ile Val Pro Ala Tyr Val Leu Ser Gln Val Thr Leu Lys         
    10                  15                  20                          

gag tct ggc cct ggg ata ttg cag ccc tcc cag acc ctc agt ctg act      148
Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr         
25                  30                  35                  40          

tgt tct ttc tct ggg ttt tca ctg agc act tct ggt atg ggt gtg agc      196
Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Ser         
                45                  50                  55              

tgg att cgt cag cct tca gga aag ggt ctg gag tgg ctg gca cac att      244
Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile         
            60                  65                  70                  

tac tgg gat gat gac aag cgc tat aac cca tcc ctg aag agc cgg ctc      292
Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser Arg Leu         
        75                  80                  85                      

aca atc tcc aag gat acc tcc agc aac cag gta ttc ctc aag atc acc      340
Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val Phe Leu Lys Ile Thr         
    90                  95                  100                         

agt gtg gac act gca gat act gcc aca tac tac tgt gct cga gat tac      388
Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Tyr         
105                 110                 115                 120         

tac gct agt agc ttt gac tac tgg ggc caa ggc acc act ctc aca gtc      436
Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val         
                125                 130                 135             

tcc tca                                                              442
Ser Ser                                                                 
                                                                        


<210>  6
<211>  138
<212>  PRT
<213>  Mus sp.

<400>  6

Met Asn Arg Leu Thr Ser Ser Leu Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210>  7
<211>  401
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (18)..(401)

<400>  7
tcagggaaag ctcgaag atg gtt ttc aca cct cag att ctt gga ctt atg        50
                   Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met          
                   1               5                   10               

ctt ttc tgg att tca gcc tcc aga ggt gat att gtg cta act cag tct       98
Leu Phe Trp Ile Ser Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser         
            15                  20                  25                  

cca gcc acc ctg tct gtg act cca gga gat aga gtc agt ctt tcc tgc      146
Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys         
        30                  35                  40                      

agg gcc agt caa agt att agc aac tac cta cac tgg tat caa caa aaa      194
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys         
    45                  50                  55                          

tca cat gag tct cca agg ctt ctc atc aag tat gct tcc cag tcc atc      242
Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile         
60                  65                  70                  75          

tct ggg atc ccc tcc agg ttc agt ggc agt gga tca ggg aca gat ttc      290
Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe         
                80                  85                  90              

att ctc agt ttc aac agt gtg gag act gaa gat ttt gga atg tat ttc      338
Ile Leu Ser Phe Asn Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe         
            95                  100                 105                 

tgt caa cag agt aac agc tgg cct ttc acg ttc ggc tcg ggg aca aaa      386
Cys Gln Gln Ser Asn Ser Trp Pro Phe Thr Phe Gly Ser Gly Thr Lys         
        110                 115                 120                     

ttg gaa ata aaa cgg                                                  401
Leu Glu Ile Lys Arg                                                     
    125                                                                 


<210>  8
<211>  128
<212>  PRT
<213>  Mus sp.

<400>  8

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn 
            100                 105                 110         


Ser Trp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


<210>  9
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  9

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  10
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  10

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  11
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  11

Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr 
1               5                   


<210>  12
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  12

Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu His 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  13

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  14

Gln Gln Ser Asn Ser Trp Pro Phe Thr 
1               5                   


<210>  15
<211>  1395
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(1395)

<400>  15
atg gac tcc agg ctc aat tta gtt ttc ctt gtc ctt att tta aaa ggt       48
Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly         
1               5                   10                  15              

gtc cag tgt gat gtg cag ctg gtg gag tct ggg gga ggc tta gtg cag       96
Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln         
            20                  25                  30                  

cct gga ggg tcc cgg aaa ctc tcc tgt gca gcc tct gga ttc act ttc      144
Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe         
        35                  40                  45                      

agt aac ttt gga atg cac tgg gtt cgt cag gct cca gag aag gga ctg      192
Ser Asn Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu         
    50                  55                  60                          

gag tgg gtc gca tac att agt agt ggc agt agt acc atc tac tat gca      240
Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala         
65                  70                  75                  80          

gac aca gtg aag ggc cga ttc acc atc tcc aga gac aat ccc aag aac      288
Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn         
                85                  90                  95              

acc ctg ttc ctg caa atg acc agt cta agg tct gag gac acg gcc atg      336
Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met         
            100                 105                 110                 

tat tac tgt gca aga tat gat tac gac gat gat tac tat gct atg gaa      384
Tyr Tyr Cys Ala Arg Tyr Asp Tyr Asp Asp Asp Tyr Tyr Ala Met Glu         
        115                 120                 125                     

tac tgg ggt caa gga acc tca gtc acc gtc tcc tca gcc aaa acg aca      432
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr         
    130                 135                 140                         

ccc cca tct gtc tat cca ctg gcc cct gga tct gct gcc caa act aac      480
Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn         
145                 150                 155                 160         

tcc atg gtg acc ctg gga tgc ctg gtc aag ggc tat ttc cct gag cca      528
Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro         
                165                 170                 175             

gtg aca gtg acc tgg aac tct gga tcc ctg tcc agc ggt gtg cac acc      576
Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr         
            180                 185                 190                 

ttc cca gct gtc ctg cag tct gac ctc tac act ctg agc agc tca gtg      624
Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val         
        195                 200                 205                     

act gtc ccc tcc agc acc tgg ccc agc gag acc gtc acc tgc aac gtt      672
Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val         
    210                 215                 220                         

gcc cac ccg gcc agc agc acc aag gtg gac aag aaa att gtg ccc agg      720
Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg         
225                 230                 235                 240         

gat tgt ggt tgt aag cct tgc ata tgt aca gtc cca gaa gta tca tct      768
Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser         
                245                 250                 255             

gtc ttc atc ttc ccc cca aag ccc aag gat gtg ctc acc att act ctg      816
Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu         
            260                 265                 270                 

act cct aag gtc acg tgt gtt gtg gta gac atc agc aag gat gat ccc      864
Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro         
        275                 280                 285                     

gag gtc cag ttc agc tgg ttt gta gat gat gtg gag gtg cac aca gct      912
Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala         
    290                 295                 300                         

cag acg caa ccc cgg gag gag cag ttc aac agc act ttc cgc tca gtc      960
Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val         
305                 310                 315                 320         

agt gaa ctt ccc atc atg cac cag gac tgg ctc aat ggc aag gag ttc     1008
Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe         
                325                 330                 335             

aaa tgc agg gtc aac agt gca gct ttc cct gcc ccc atc gag aaa acc     1056
Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr         
            340                 345                 350                 

atc tcc aaa acc aaa ggc aga ccg aag gct cca cag gtg tac acc att     1104
Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile         
        355                 360                 365                     

cca cct ccc aag gag cag atg gcc aag gat aaa gtc agt ctg acc tgc     1152
Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys         
    370                 375                 380                         

atg ata aca gac ttc ttc cct gaa gac att act gtg gag tgg cag tgg     1200
Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp         
385                 390                 395                 400         

aat ggg cag cca gcg gag aac tac aag aac act cag ccc atc atg gac     1248
Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp         
                405                 410                 415             

aca gat ggc tct tac ttc gtc tac agc aag ctc aat gtg cag aag agc     1296
Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser         
            420                 425                 430                 

aac tgg gag gca gga aat act ttc acc tgc tct gtg tta cat gag ggc     1344
Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly         
        435                 440                 445                     

ctg cac aac cac cat act gag aag agc ctc tcc cac tct cct ggt aag     1392
Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys         
    450                 455                 460                         

tga                                                                 1395


<210>  16
<211>  464
<212>  PRT
<213>  Mus sp.

<400>  16

Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Asp Tyr Asp Asp Asp Tyr Tyr Ala Met Glu 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     


Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 


<210>  17
<211>  705
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(705)

<400>  17
atg gcc tgg att tca ctt ata ctc tct ctc ctg gct ctc agc tca ggg       48
Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly         
1               5                   10                  15              

gcc att tcc cag gct gtt gtg act cag gaa tct gca ctc acc aca tca       96
Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser         
            20                  25                  30                  

cct ggt gaa aca gtc aca ctc act tgt cgc tca agt act ggg gct gtt      144
Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val         
        35                  40                  45                      

aca act agt aac tat gcc aac tgg gtc caa gaa aaa cca gat cat tta      192
Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu         
    50                  55                  60                          

ttc act ggt cta ata ggt ggt acc aac aac cga gct cca ggt gtt cct      240
Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro         
65                  70                  75                  80          

gcc aga ttc tca ggc tcc ctg att gga gac aag gct gcc ctc acc atc      288
Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile         
                85                  90                  95              

aca ggg gca cag act gag gat gag gca ata tat ttc tgt gct cta tgg      336
Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp         
            100                 105                 110                 

tac agc aac cat tgg gtg ttc ggt gga gga acc aaa ctg act gtc cta      384
Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu         
        115                 120                 125                     

ggc cag ccc aag tct tcg cca tca gtc acc ctg ttt cca cct tcc tct      432
Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser         
    130                 135                 140                         

gaa gag ctc gag act aac aag gcc aca ctg gtg tgt acg atc act gat      480
Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp         
145                 150                 155                 160         

ttc tac cca ggt gtg gtg aca gtg gac tgg aag gta gat ggt acc cct      528
Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro         
                165                 170                 175             

gtc act cag ggt atg gag aca acc cag cct tcc aaa cag agc aac aac      576
Val Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn         
            180                 185                 190                 

aag tac atg gct agc agc tac ctg acc ctg aca gca aga gca tgg gaa      624
Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu         
        195                 200                 205                     

agg cat agc agt tac agc tgc cag gtc act cat gaa ggt cac act gtg      672
Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val         
    210                 215                 220                         

gag aag agt ttg tcc cgt gct gac tgt tcc tag                          705
Glu Lys Ser Leu Ser Arg Ala Asp Cys Ser                                 
225                 230                                                 


<210>  18
<211>  234
<212>  PRT
<213>  Mus sp.

<400>  18

Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro 
                165                 170                 175     


Val Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu 
        195                 200                 205             


Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val 
    210                 215                 220                 


Glu Lys Ser Leu Ser Arg Ala Asp Cys Ser 
225                 230                 


<210>  19
<211>  420
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(420)

<400>  19
atg gac tcc agg ctc aat tta gtt ttc ctt gtc ctt att tta aaa ggt       48
Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly         
1               5                   10                  15              

gtc cag tgt gat gtg cag ctg gtg gag tct ggg gga ggc tta gtg cag       96
Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln         
            20                  25                  30                  

cct gga ggg tcc cgg aaa ctc tcc tgt gca gcc tct gga ttc act ttc      144
Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe         
        35                  40                  45                      

agt aac ttt gga atg cac tgg gtt cgt cag gct cca gag aag gga ctg      192
Ser Asn Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu         
    50                  55                  60                          

gag tgg gtc gca tac att agt agt ggc agt agt acc atc tac tat gca      240
Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala         
65                  70                  75                  80          

gac aca gtg aag ggc cga ttc acc atc tcc aga gac aat ccc aag aac      288
Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn         
                85                  90                  95              

acc ctg ttc ctg caa atg acc agt cta agg tct gag gac acg gcc atg      336
Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met         
            100                 105                 110                 

tat tac tgt gca aga tat gat tac gac gat gat tac tat gct atg gaa      384
Tyr Tyr Cys Ala Arg Tyr Asp Tyr Asp Asp Asp Tyr Tyr Ala Met Glu         
        115                 120                 125                     

tac tgg ggt caa gga acc tca gtc acc gtc tcc tca                      420
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser                         
    130                 135                 140                         


<210>  20
<211>  140
<212>  PRT
<213>  Mus sp.

<400>  20

Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Asp Tyr Asp Asp Asp Tyr Tyr Ala Met Glu 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  21
<211>  412
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (29)..(412)

<400>  21
tgaaaagaat agacctggtt tgtgaatt atg gcc tgg att tca ctt ata ctc        52
                               Met Ala Trp Ile Ser Leu Ile Leu          
                               1               5                        

tct ctc ctg gct ctc agc tca ggg gcc att tcc cag gct gtt gtg act      100
Ser Leu Leu Ala Leu Ser Ser Gly Ala Ile Ser Gln Ala Val Val Thr         
    10                  15                  20                          

cag gaa tct gca ctc acc aca tca cct ggt gaa aca gtc aca ctc act      148
Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr         
25                  30                  35                  40          

tgt cgc tca agt act ggg gct gtt aca act agt aac tat gcc aac tgg      196
Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp         
                45                  50                  55              

gtc caa gaa aaa cca gat cat tta ttc act ggt cta ata ggt ggt acc      244
Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr         
            60                  65                  70                  

aac aac cga gct cca ggt gtt cct gcc aga ttc tca ggc tcc ctg att      292
Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile         
        75                  80                  85                      

gga gac aag gct gcc ctc acc atc aca ggg gca cag act gag gat gag      340
Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu         
    90                  95                  100                         

gca ata tat ttc tgt gct cta tgg tac agc aac cat tgg gtg ttc ggt      388
Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly         
105                 110                 115                 120         

gga gga acc aaa ctg act gtc cta                                      412
Gly Gly Thr Lys Leu Thr Val Leu                                         
                125                                                     


<210>  22
<211>  128
<212>  PRT
<213>  Mus sp.

<400>  22

Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  23
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  23

Asn Phe Gly Met His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  24

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  12
<212>  PRT
<213>  Mus sp.

<400>  25

Tyr Asp Tyr Asp Asp Asp Tyr Tyr Ala Met Glu Tyr 
1               5                   10          


<210>  26
<211>  14
<212>  PRT
<213>  Mus sp.

<400>  26

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  27
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  27

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  28

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  29
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(321)

<400>  29
cag tct gcc ctg act cag tcc cca gca act ctc tct gtg tct ccc ggc       48
Gln Ser Ala Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly         
1               5                   10                  15              

caa tct gtg agc ctg tcc tgt cgg gca agc cag tct att tcc aat tat       96
Gln Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr         
            20                  25                  30                  

ctg cac tgg tat cag caa cac cca ggc gag agc cca cgg ctc ctg atc      144
Leu His Trp Tyr Gln Gln His Pro Gly Glu Ser Pro Arg Leu Leu Ile         
        35                  40                  45                      

aaa tac gcc tct caa tcc att tct ggc tcc aac aga cgc ttc tct ggc      192
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ser Asn Arg Arg Phe Ser Gly         
    50                  55                  60                          

agc ggc tcc ggc acc gat ttc att ctc agc ttt aat agc gtt cag gca      240
Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn Ser Val Gln Ala         
65                  70                  75                  80          

gag gat ttt ggg atg tac ttc tgt caa cag agc aac tct tgg cct ttt      288
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Phe         
                85                  90                  95              

acc ttc gga agc ggg act aaa ctg acc gtt ctg                          321
Thr Phe Gly Ser Gly Thr Lys Leu Thr Val Leu                             
            100                 105                                     


<210>  30
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  30

Gln Ser Ala Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln His Pro Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ser Asn Arg Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  31
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(321)

<400>  31
caa tct gca ctg act caa tct cca gca aca ctg tcc gtt tct cct gga       48
Gln Ser Ala Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly         
1               5                   10                  15              

caa tcc gtg agc ctc agc tgt agg gca tcc cag tcc att agc aac tat       96
Gln Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr         
            20                  25                  30                  

ctc cac tgg tac cag cag cac cca gga gaa agc cct cgc ctg ctg ata      144
Leu His Trp Tyr Gln Gln His Pro Gly Glu Ser Pro Arg Leu Leu Ile         
        35                  40                  45                      

aaa tac gca agc cag tct att agc ggc agc aac cgg cgc ttc agc ggg      192
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ser Asn Arg Arg Phe Ser Gly         
    50                  55                  60                          

tcc ggc tcc ggg aca gac ttt atc ctg tct ttt agc agc gtg caa gcc      240
Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Ser Ser Val Gln Ala         
65                  70                  75                  80          

gaa gac ttt ggc atg tac ttc tgc cag cag tct aac aat tgg cca ttc      288
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Asn Trp Pro Phe         
                85                  90                  95              

acc ttc gga tcc ggc aca aag ctg acc gtg ctg                          321
Thr Phe Gly Ser Gly Thr Lys Leu Thr Val Leu                             
            100                 105                                     


<210>  32
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  32

Gln Ser Ala Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln His Pro Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ser Asn Arg Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  33
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(342)

<400>  33
cag gtt act ctg aaa gaa tct ggc cca act ctg gtt aag cct aca cag       48
Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln         
1               5                   10                  15              

acc ctg tcc ctc acc tgt tct ttc tcc ggc ttt agc ctg agc aca agc       96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser         
            20                  25                  30                  

gga atg ggc gtc agc tgg atc aga caa cca ccc ggc aag ggc ctg gag      144
Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu         
        35                  40                  45                      

tgg ctg gcc cac atc tat tgg gat gat gat aag agg tat aac cct tcc      192
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser         
    50                  55                  60                          

ctg aaa tcc aga ctc aca att tcc aag gac acc tcc agc aac cag gtc      240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val         
65                  70                  75                  80          

ttc ctg aag ata acc tct gtt gat cca gtg gac acc gca act tac tac      288
Phe Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr         
                85                  90                  95              

tgc gcc cgc gac tac tat gcc agc tct ttt gac tac tgg ggg cag ggc      336
Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

aca ctc                                                              342
Thr Leu                                                                 
                                                                        


<210>  34
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  34

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu 
        


<210>  35
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(342)

<400>  35
cag gtg act ctc aaa gaa tct ggc cct aca ctg gtg aaa ccc act cag       48
Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln         
1               5                   10                  15              

aca ctc agc ctg acc tgc tcc ttc agc ggc ttc tct ctg agc act tcc       96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser         
            20                  25                  30                  

gga ctc gga gtg agc tgg att cgc caa cct cct ggg aaa ggc ctg gag      144
Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu         
        35                  40                  45                      

tgg ctg gca cac ata tac tgg gat gac gac aaa cgc tat aac cct agc      192
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser         
    50                  55                  60                          

ctg aag tcc aga ctc aca atc tcc aaa gat aca tcc agc aat cag gtg      240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val         
65                  70                  75                  80          

ttt ctg aag atc acc tcc gtc gat cca gtc gac acc gcc act tac tat      288
Phe Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr         
                85                  90                  95              

tgt gct cgc gat tac tat gcc agc tcc ttc gac tac tgg gga cag gga      336
Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

aca ctg                                                              342
Thr Leu                                                                 
                                                                        


<210>  36
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  36

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu 
        


<210>  37
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Squence humanise


<220>
<221>  CDS
<222>  (1)..(342)

<400>  37
cag gtc aca ctc aaa gaa tct gga cca aca ctc gtt aaa cca act caa       48
Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln         
1               5                   10                  15              

aca ctc agc ctg act tgc agc ttt tct ggc ttc agc ctc tcc act agc       96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser         
            20                  25                  30                  

ggc ctc ggc gtg tcc tgg atc cgg cag ccc cct gga aaa ggc ctg gag      144
Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu         
        35                  40                  45                      

tgg ctg gcc cac atc tat tgg gac gat gac aag cgg tac aat cca agc      192
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser         
    50                  55                  60                          

ctg aaa tct cgg ctg acc ata tct aag gat act tct tcc aat cag gtg      240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val         
65                  70                  75                  80          

ttc ctg aag atc aca tct gtg gct cct gtc gac act gcc act tat tat      288
Phe Leu Lys Ile Thr Ser Val Ala Pro Val Asp Thr Ala Thr Tyr Tyr         
                85                  90                  95              

tgc gca agg gat tac tac gca tcc tcc ttc gat tac tgg ggc cag gga      336
Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

act ctg                                                              342
Thr Leu                                                                 
                                                                        


<210>  38
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  38

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Ala Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu 
        


<210>  39
<211>  1059
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1059)

<400>  39
ctg gag gcc tct gag gaa gtg gag ctt gag ccc tgc ctg gct ccc agc       48
Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser         
1               5                   10                  15              

ctg gag cag caa gag cag gag ctg aca gta gcc ctt ggg cag cct gtg       96
Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val         
            20                  25                  30                  

cgg ctg tgc tgt ggg cgg gct gag cgt ggt ggc cac tgg tac aag gag      144
Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly His Trp Tyr Lys Glu         
        35                  40                  45                      

ggc agt cgc ctg gca cct gct ggc cgt gta cgg ggc tgg agg ggc cgc      192
Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg Gly Trp Arg Gly Arg         
    50                  55                  60                          

cta gag att gcc agc ttc cta cct gag gat gct ggc cgc tac ctc tgc      240
Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys         
65                  70                  75                  80          

ctg gca cga ggc tcc atg atc gtc ctg cag aat ctc acc ttg att aca      288
Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr         
                85                  90                  95              

ggt gac tcc ttg acc tcc agc aac gat gat gag gac ccc aag tcc cat      336
Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu Asp Pro Lys Ser His         
            100                 105                 110                 

agg gac ctc tcg aat agg cac agt tac ccc cag caa gca ccc tac tgg      384
Arg Asp Leu Ser Asn Arg His Ser Tyr Pro Gln Gln Ala Pro Tyr Trp         
        115                 120                 125                     

aca cac ccc cag cgc atg gag aag aaa ctg cat gca gta cct gcg ggg      432
Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala Gly         
    130                 135                 140                         

aac acc gtc aag ttc cgc tgt cca gct gca ggc aac ccc acg ccc acc      480
Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr         
145                 150                 155                 160         

atc cgc tgg ctt aag gat gga cag gcc ttt cat ggg gag aac cgc att      528
Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile         
                165                 170                 175             

gga ggc att cgg ctg cgc cat cag cac tgg agt ctc gtg atg gag agc      576
Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu Ser         
            180                 185                 190                 

gtg gtg ccc tcg gac cgc ggc aca tac acc tgc ctg gta gag aac gct      624
Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala         
        195                 200                 205                     

gtg ggc agc atc cgt tat aac tac ctg cta gat gtg ctg gag cgg tcc      672
Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser         
    210                 215                 220                         

ccg cac cgg ccc atc ctg cag gcc ggg ctc ccg gcc aac acc aca gcc      720
Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala         
225                 230                 235                 240         

gtg gtg ggc agc gac gtg gag ctg ctg tgc aag gtg tac agc gat gcc      768
Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala         
                245                 250                 255             

cag ccc cac atc cag tgg ctg aag cac atc gtc atc aac ggc agc agc      816
Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser         
            260                 265                 270                 

ttc gga gcc gac ggt ttc ccc tat gtg caa gtc cta aag act gca gac      864
Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Ala Asp         
        275                 280                 285                     

atc aat agc tca gag gtg gag gtc ctg tac ctg cgg aac gtg tca gcc      912
Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala         
    290                 295                 300                         

gag gac gca ggc gag tac acc tgc ctc gca ggc aat tcc atc ggc ctc      960
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu         
305                 310                 315                 320         

tcc tac cag tct gcc tgg ctc acg gtg ctg cca gag gag gac ccc aca     1008
Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp Pro Thr         
                325                 330                 335             

tgg acc gca gca gcg ccc gag gcc gct agc cat cac cat cat cat cac     1056
Trp Thr Ala Ala Ala Pro Glu Ala Ala Ser His His His His His His         
            340                 345                 350                 

tga                                                                 1059


<210>  40
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser 
1               5                   10                  15      


Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val 
            20                  25                  30          


Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly His Trp Tyr Lys Glu 
        35                  40                  45              


Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg Gly Trp Arg Gly Arg 
    50                  55                  60                  


Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys 
65                  70                  75                  80  


Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr 
                85                  90                  95      


Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu Asp Pro Lys Ser His 
            100                 105                 110         


Arg Asp Leu Ser Asn Arg His Ser Tyr Pro Gln Gln Ala Pro Tyr Trp 
        115                 120                 125             


Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala Gly 
    130                 135                 140                 


Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr 
145                 150                 155                 160 


Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile 
                165                 170                 175     


Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu Ser 
            180                 185                 190         


Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala 
        195                 200                 205             


Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser 
    210                 215                 220                 


Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala 
225                 230                 235                 240 


Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala 
                245                 250                 255     


Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser 
            260                 265                 270         


Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Ala Asp 
        275                 280                 285             


Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala 
    290                 295                 300                 


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu 
305                 310                 315                 320 


Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp Pro Thr 
                325                 330                 335     


Trp Thr Ala Ala Ala Pro Glu Ala Ala Ser His His His His His His 
            340                 345                 350         


<210>  41
<211>  726
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(726)

<400>  41
ctg gag gcc tct gag gaa gtg gag ctt gag ccc tgc caa gca ccc tac       48
Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro Cys Gln Ala Pro Tyr         
1               5                   10                  15              

tgg aca cac ccc cag cgc atg gag aag aaa ctg cat gca gta cct gcg       96
Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala         
            20                  25                  30                  

ggg aac acc gtc aag ttc cgc tgt cca gct gca ggc aac ccc acg ccc      144
Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro         
        35                  40                  45                      

acc atc cgc tgg ctt aag gat gga cag gcc ttt cat ggg gag aac cgc      192
Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg         
    50                  55                  60                          

att gga ggc att cgg ctg cgc cat cag cac tgg agt ctc gtg atg gag      240
Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu         
65                  70                  75                  80          

agc gtg gtg ccc tcg gac cgc ggc aca tac acc tgc ctg gta gag aac      288
Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn         
                85                  90                  95              

gct gtg ggc agc atc cgt tat aac tac ctg cta gat gtg ctg gag cgg      336
Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg         
            100                 105                 110                 

tcc ccg cac cgg ccc atc ctg cag gcc ggg ctc ccg gcc aac acc aca      384
Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr         
        115                 120                 125                     

gcc gtg gtg ggc agc gac gtg gag ctg ctg tgc aag gtg tac agc gat      432
Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp         
    130                 135                 140                         

gcc cag ccc cac atc cag tgg ctg aag cac atc gtc atc aac ggc agc      480
Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser         
145                 150                 155                 160         

agc ttc gga gcc gac ggt ttc ccc tat gtg caa gtc cta aag act gca      528
Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Ala         
                165                 170                 175             

gac atc aat agc tca gag gtg gag gtc ctg tac ctg cgg aac gtg tca      576
Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser         
            180                 185                 190                 

gcc gag gac gca ggc gag tac acc tgc ctc gca ggc aat tcc atc ggc      624
Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly         
        195                 200                 205                     

ctc tcc tac cag tct gcc tgg ctc acg gtg ctg cca gag gag gac ccc      672
Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp Pro         
    210                 215                 220                         

aca tgg acc gca gca gcg ccc gag gcc gct agc cat cac cat cat cat      720
Thr Trp Thr Ala Ala Ala Pro Glu Ala Ala Ser His His His His His         
225                 230                 235                 240         

cac tga                                                              726
His                                                                     
                                                                        


<210>  42
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro Cys Gln Ala Pro Tyr 
1               5                   10                  15      


Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala 
            20                  25                  30          


Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro 
        35                  40                  45              


Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg 
    50                  55                  60                  


Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu 
65                  70                  75                  80  


Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn 
                85                  90                  95      


Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg 
            100                 105                 110         


Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr 
        115                 120                 125             


Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp 
    130                 135                 140                 


Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser 
145                 150                 155                 160 


Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Ala 
                165                 170                 175     


Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser 
            180                 185                 190         


Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
        195                 200                 205             


Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp Pro 
    210                 215                 220                 


Thr Trp Thr Ala Ala Ala Pro Glu Ala Ala Ser His His His His His 
225                 230                 235                 240 


His 
    


<210>  43
<211>  1059
<212>  DNA
<213>  Mus sp.


<220>
<221>  CDS
<222>  (1)..(1059)

<400>  43
ctt gag gcc tct gag gaa atg gag cag gag ccc tgc cta gcc cca atc       48
Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Leu Ala Pro Ile         
1               5                   10                  15              

ctg gag cag caa gag cag gtg ttg acg gtg gcc ctg ggg cag cct gtg       96
Leu Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln Pro Val         
            20                  25                  30                  

agg ctg tgc tgt ggg cgc acc gag cgt ggt cgt cac tgg tac aaa gag      144
Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr Lys Glu         
        35                  40                  45                      

ggc agc cgc cta gca tct gct ggg cga gta cgg ggt tgg aga ggc cgc      192
Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg Gly Arg         
    50                  55                  60                          

ctg gag atc gcc agc ttc ctt cct gag gat gct ggc cga tac ctc tgc      240
Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys         
65                  70                  75                  80          

ctg gcc cgt ggc tcc atg acc gtc gta cac aat ctt acg ttg ctt atg      288
Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu Leu Met         
                85                  90                  95              

gat gac tcc tta acc tcc atc agt aat gat gaa gac ccc aag aca ctc      336
Asp Asp Ser Leu Thr Ser Ile Ser Asn Asp Glu Asp Pro Lys Thr Leu         
            100                 105                 110                 

agc agc tcc tcg agt ggt cat gtc tac cca cag caa gca ccc tac tgg      384
Ser Ser Ser Ser Ser Gly His Val Tyr Pro Gln Gln Ala Pro Tyr Trp         
        115                 120                 125                     

aca cac ccc caa cgc atg gag aag aaa ctg cat gca gtg cct gcc ggg      432
Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala Gly         
    130                 135                 140                         

aat act gtc aaa ttc cgc tgt cca gct gca ggg aac ccc atg cct acc      480
Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met Pro Thr         
145                 150                 155                 160         

atc cac tgg ctc aag gat gga cag gcc ttc cac ggg gag aat cgt att      528
Ile His Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile         
                165                 170                 175             

gga ggc att cgg ctg cgc cac caa cac tgg agc ctg gtg atg gaa agt      576
Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu Ser         
            180                 185                 190                 

gtg gta ccc tcg gac cgt ggc aca tac aca tgc ctt gtg gag aac tct      624
Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ser         
        195                 200                 205                     

ctg ggt agc att cgc tac agc tat ctc ctg gat gtg ctg gag cgg tcc      672
Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg Ser         
    210                 215                 220                         

ccg cac cgg ccc atc ctg cag gcg ggg ctc cca gcc aac acc aca gct      720
Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala         
225                 230                 235                 240         

gtg gtg ggc agc gac gtg gag cta ctc tgc aag gtg tac agc gac gcc      768
Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala         
                245                 250                 255             

cag ccc cac ata cag tgg ctg aaa cac gtc gtc atc aac ggc agc agc      816
Gln Pro His Ile Gln Trp Leu Lys His Val Val Ile Asn Gly Ser Ser         
            260                 265                 270                 

ttc ggc gcc gac ggt ttc ccc tac gta caa gtc ctg aag aca aca gac      864
Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Thr Asp         
        275                 280                 285                     

atc aat agc tcg gag gta gag gtc ttg tat ctg agg aac gtg tcc gct      912
Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala         
    290                 295                 300                         

gag gat gca gga gag tat acc tgt ctg gcg ggc aac tcc atc ggc ctt      960
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu         
305                 310                 315                 320         

tcc tac cag tca gcg tgg ctc acg gtg ctg cca gag gaa gac ctc acg     1008
Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp Leu Thr         
                325                 330                 335             

tgg aca aca gca acc cct gag gcc gct agc cat cac cat cat cat cac     1056
Trp Thr Thr Ala Thr Pro Glu Ala Ala Ser His His His His His His         
            340                 345                 350                 

tga                                                                 1059


<210>  44
<211>  352
<212>  PRT
<213>  Mus sp.

<400>  44

Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Leu Ala Pro Ile 
1               5                   10                  15      


Leu Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln Pro Val 
            20                  25                  30          


Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr Lys Glu 
        35                  40                  45              


Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg Gly Arg 
    50                  55                  60                  


Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys 
65                  70                  75                  80  


Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu Leu Met 
                85                  90                  95      


Asp Asp Ser Leu Thr Ser Ile Ser Asn Asp Glu Asp Pro Lys Thr Leu 
            100                 105                 110         


Ser Ser Ser Ser Ser Gly His Val Tyr Pro Gln Gln Ala Pro Tyr Trp 
        115                 120                 125             


Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala Gly 
    130                 135                 140                 


Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met Pro Thr 
145                 150                 155                 160 


Ile His Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile 
                165                 170                 175     


Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu Ser 
            180                 185                 190         


Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ser 
        195                 200                 205             


Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg Ser 
    210                 215                 220                 


Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala 
225                 230                 235                 240 


Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala 
                245                 250                 255     


Gln Pro His Ile Gln Trp Leu Lys His Val Val Ile Asn Gly Ser Ser 
            260                 265                 270         


Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Thr Asp 
        275                 280                 285             


Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala 
    290                 295                 300                 


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu 
305                 310                 315                 320 


Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp Leu Thr 
                325                 330                 335     


Trp Thr Thr Ala Thr Pro Glu Ala Ala Ser His His His His His His 
            340                 345                 350         


<210>  45
<211>  1773
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1773)

<400>  45
agg ccg tcc ccg acc ttg cct gaa caa gcc cag ccc tgg gga gcc cct       48
Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln Pro Trp Gly Ala Pro         
1               5                   10                  15              

gtg gaa gtg gag tcc ttc ctg gtc cac ccc ggt gac ctg ctg cag ctt       96
Val Glu Val Glu Ser Phe Leu Val His Pro Gly Asp Leu Leu Gln Leu         
            20                  25                  30                  

cgc tgt cgg ctg cgg gac gat gtg cag agc atc aac tgg ctg cgg gac      144
Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile Asn Trp Leu Arg Asp         
        35                  40                  45                      

ggg gtg cag ctg gcg gaa agc aac cgc acc cgc atc aca ggg gag gag      192
Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg Ile Thr Gly Glu Glu         
    50                  55                  60                          

gtg gag gtg cag gac tcc gtg ccc gca gac tcc ggc ctc tat gct tgc      240
Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser Gly Leu Tyr Ala Cys         
65                  70                  75                  80          

gta acc agc agc ccc tcg ggc agt gac acc acc tac ttc tcc gtc aat      288
Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr Tyr Phe Ser Val Asn         
                85                  90                  95              

gtt tca gat gct ctc ccc tcc tcg gag gat gat gat gat gat gat gac      336
Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp         
            100                 105                 110                 

tcc tct tca gag gag aaa gaa aca gat aac acc aaa cca aac cgt atg      384
Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met         
        115                 120                 125                     

ccc gta gct cca tat tgg aca tcc cca gaa aag atg gaa aag aaa ttg      432
Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu         
    130                 135                 140                         

cat gca gtg ccg gct gcc aag aca gtg aag ttc aaa tgc cct tcc agt      480
His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser         
145                 150                 155                 160         

ggg acc cca aac ccc aca ctg cgc tgg ttg aaa aat ggc aaa gaa ttc      528
Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe         
                165                 170                 175             

aaa cct gac cac aga att gga ggc tac aag gtc cgt tat gcc acc tgg      576
Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp         
            180                 185                 190                 

agc atc ata atg gac tct gtg gtg ccc tct gac aag ggc aac tac acc      624
Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr         
        195                 200                 205                     

tgc att gtg gag aat gag tac ggc agc atc aac cac aca tac cag ctg      672
Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu         
    210                 215                 220                         

gat gtc gtg gag cgg tcc cct cac cgg ccc atc ctg caa gca ggg ttg      720
Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu         
225                 230                 235                 240         

ccc gcc aac aaa aca gtg gcc ctg ggt agc aac gtg gag ttc atg tgt      768
Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys         
                245                 250                 255             

aag gtg tac agt gac ccg cag ccg cac atc cag tgg cta aag cac atc      816
Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile         
            260                 265                 270                 

gag gtg aat ggg agc aag att ggc cca gac aac ctg cct tat gtc cag      864
Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln         
        275                 280                 285                     

atc ttg aag act gct gga gtt aat acc acc gac aaa gag atg gag gtg      912
Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val         
    290                 295                 300                         

ctt cac tta aga aat gtc tcc ttt gag gac gca ggg gag tat acg tgc      960
Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys         
305                 310                 315                 320         

ttg gcg ggt aac tct atc gga ctc tcc cat cac tct gca tgg ttg acc     1008
Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr         
                325                 330                 335             

gtt ctg gaa gcc ctg gaa gag agg ccg gca gtg atg acc tcg ccc ctg     1056
Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu         
            340                 345                 350                 

tac ctg gag ata gcg cta gag ccc aaa tct tgt gac aaa act cac aca     1104
Tyr Leu Glu Ile Ala Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr         
        355                 360                 365                     

tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc     1152
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe         
    370                 375                 380                         

ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct     1200
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro         
385                 390                 395                 400         

gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc     1248
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val         
                405                 410                 415             

aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca     1296
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr         
            420                 425                 430                 

aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc     1344
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val         
        435                 440                 445                     

ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc     1392
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys         
    450                 455                 460                         

aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc     1440
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser         
465                 470                 475                 480         

aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca     1488
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro         
                485                 490                 495             

tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc     1536
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val         
            500                 505                 510                 

aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg     1584
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly         
        515                 520                 525                     

cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac     1632
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp         
    530                 535                 540                         

ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg     1680
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp         
545                 550                 555                 560         

cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac     1728
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His         
                565                 570                 575             

aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa tga         1773
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                 
            580                 585                 590                 


<210>  46
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  46

Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln Pro Trp Gly Ala Pro 
1               5                   10                  15      


Val Glu Val Glu Ser Phe Leu Val His Pro Gly Asp Leu Leu Gln Leu 
            20                  25                  30          


Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile Asn Trp Leu Arg Asp 
        35                  40                  45              


Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg Ile Thr Gly Glu Glu 
    50                  55                  60                  


Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser Gly Leu Tyr Ala Cys 
65                  70                  75                  80  


Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr Tyr Phe Ser Val Asn 
                85                  90                  95      


Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp 
            100                 105                 110         


Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met 
        115                 120                 125             


Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu 
    130                 135                 140                 


His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser 
145                 150                 155                 160 


Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe 
                165                 170                 175     


Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp 
            180                 185                 190         


Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr 
        195                 200                 205             


Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu 
    210                 215                 220                 


Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu 
225                 230                 235                 240 


Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys 
                245                 250                 255     


Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile 
            260                 265                 270         


Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln 
        275                 280                 285             


Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val 
    290                 295                 300                 


Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys 
305                 310                 315                 320 


Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr 
                325                 330                 335     


Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu 
            340                 345                 350         


Tyr Leu Glu Ile Ala Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        355                 360                 365             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    370                 375                 380                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
385                 390                 395                 400 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                405                 410                 415     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            420                 425                 430         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        435                 440                 445             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    450                 455                 460                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
465                 470                 475                 480 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                485                 490                 495     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            500                 505                 510         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        515                 520                 525             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    530                 535                 540                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
545                 550                 555                 560 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                565                 570                 575     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585                 590 


<210>  47
<211>  1773
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1773)

<400>  47
cgg ccc tcc ttc agt tta gtt gag gat acc aca tta gag cca gaa gag       48
Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu         
1               5                   10                  15              

cca cca acc aaa tac caa atc tct caa cca gaa gtg tac gtg gct gca       96
Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala         
            20                  25                  30                  

cca ggg gag tcg cta gag gtg cgc tgc ctg ttg aaa gat gcc gcc gtg      144
Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val         
        35                  40                  45                      

atc agt tgg act aag gat ggg gtg cac ttg ggg ccc aac aat agg aca      192
Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr         
    50                  55                  60                          

gtg ctt att ggg gag tac ttg cag ata aag ggc gcc acg cct aga gac      240
Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp         
65                  70                  75                  80          

tcc ggc ctc tat gct tgt act gcc agt agg act gta gac agt gaa act      288
Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr         
                85                  90                  95              

tgg tac ttc atg gtg aat gtc aca gat gcc atc tca tcc gga gat gat      336
Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp         
            100                 105                 110                 

gag gat gac acc gat ggt gcg gaa gat ttt gtc agt gag aac agt aac      384
Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn         
        115                 120                 125                     

aac aag aga gca cca tac tgg acc aac aca gaa aag atg gaa aag cgg      432
Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg         
    130                 135                 140                         

ctc cat gct gtg cct gcg gcc aac act gtc aag ttt cgc tgc cca gcc      480
Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala         
145                 150                 155                 160         

ggg ggg aac cca atg cca acc atg cgg tgg ctg aaa aac ggg aag gag      528
Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu         
                165                 170                 175             

ttt aag cag gag cat cgc att gga ggc tac aag gta cga aac cag cac      576
Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His         
            180                 185                 190                 

tgg agc ctc att atg gaa agt gtg gtc cca tct gac aag gga aat tat      624
Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr         
        195                 200                 205                     

acc tgt gtg gtg gag aat gaa tac ggg tcc atc aat cac acg tac cac      672
Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His         
    210                 215                 220                         

ctg gat gtt gtg gag cga tcg cct cac cgg ccc atc ctc caa gcc gga      720
Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly         
225                 230                 235                 240         

ctg ccg gca aat gcc tcc aca gtg gtc gga gga gac gta gag ttt gtc      768
Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val         
                245                 250                 255             

tgc aag gtt tac agt gat gcc cag ccc cac atc cag tgg atc aag cac      816
Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His         
            260                 265                 270                 

gtg gaa aag aac ggc agt aaa tac ggg ccc gac ggg ctg ccc tac ctc      864
Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu         
        275                 280                 285                     

aag gtt ctc aag gcc gcc ggt gtt aac acc acg gac aaa gag att gag      912
Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu         
    290                 295                 300                         

gtt ctc tat att cgg aat gta act ttt gag gac gct ggg gaa tat acg      960
Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr         
305                 310                 315                 320         

tgc ttg gcg ggt aat tct att ggg ata tcc ttt cac tct gca tgg ttg     1008
Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu         
                325                 330                 335             

aca gtt ctg cca gcg cct gga aga gaa aag gag att aca gct tcc cca     1056
Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro         
            340                 345                 350                 

gac tac ctg tca gcg cta gag ccc aaa tct tgt gac aaa act cac aca     1104
Asp Tyr Leu Ser Ala Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr         
        355                 360                 365                     

tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc     1152
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe         
    370                 375                 380                         

ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct     1200
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro         
385                 390                 395                 400         

gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc     1248
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val         
                405                 410                 415             

aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca     1296
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr         
            420                 425                 430                 

aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc     1344
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val         
        435                 440                 445                     

ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc     1392
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys         
    450                 455                 460                         

aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc     1440
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser         
465                 470                 475                 480         

aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca     1488
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro         
                485                 490                 495             

tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc     1536
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val         
            500                 505                 510                 

aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg     1584
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly         
        515                 520                 525                     

cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac     1632
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp         
    530                 535                 540                         

ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg     1680
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp         
545                 550                 555                 560         

cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac     1728
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His         
                565                 570                 575             

aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa tga         1773
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                 
            580                 585                 590                 


<210>  48
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  48

Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu 
1               5                   10                  15      


Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala 
            20                  25                  30          


Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val 
        35                  40                  45              


Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr 
    50                  55                  60                  


Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr 
                85                  90                  95      


Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn 
        115                 120                 125             


Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg 
    130                 135                 140                 


Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His 
            180                 185                 190         


Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr 
        195                 200                 205             


Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His 
    210                 215                 220                 


Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val 
                245                 250                 255     


Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His 
            260                 265                 270         


Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu 
        275                 280                 285             


Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu 
    290                 295                 300                 


Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr 
305                 310                 315                 320 


Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu 
                325                 330                 335     


Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro 
            340                 345                 350         


Asp Tyr Leu Ser Ala Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        355                 360                 365             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    370                 375                 380                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
385                 390                 395                 400 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                405                 410                 415     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            420                 425                 430         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        435                 440                 445             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    450                 455                 460                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
465                 470                 475                 480 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                485                 490                 495     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            500                 505                 510         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        515                 520                 525             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    530                 535                 540                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
545                 550                 555                 560 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                565                 570                 575     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585                 590 


<210>  49
<211>  2403
<212>  DNA
<213>  Rattus sp.


<220>
<221>  CDS
<222>  (1)..(2403)

<400>  49
atg tgg ctg ctg ttg gct ttg ttg agc atc ttt cag gag aca cca gcc       48
Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Glu Thr Pro Ala         
1               5                   10                  15              

ttc tcc ctt gag gcc tct gag gaa atg gaa cag gag ccc tgc cca gcc       96
Phe Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Pro Ala         
            20                  25                  30                  

cca atc tcg gag cag caa gag cag gtg ttg act gtg gcc ctt ggg cag      144
Pro Ile Ser Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln         
        35                  40                  45                      

cct gtg cgg cta tgc tgt ggc cgc act gag cgt ggt cgt cat tgg tac      192
Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr         
    50                  55                  60                          

aag gag ggc agc cgt tta gca tct gct ggg aga gta cgg ggc tgg aga      240
Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg         
65                  70                  75                  80          

ggc cgc ctg gag atc gcc agc ttc ctt cct gag gat gct ggc cgg tac      288
Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr         
                85                  90                  95              

ctc tgc ctg gcc cgt ggc tcc atg act gtc gta cac aat ctt act ttg      336
Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu         
            100                 105                 110                 

att atg gat gac tcc tta ccc tcc atc aat aac gag gac ccc aag acc      384
Ile Met Asp Asp Ser Leu Pro Ser Ile Asn Asn Glu Asp Pro Lys Thr         
        115                 120                 125                     

ctc agc agc tcc tcg agt ggg cac tcc tac ctg cag caa gca cct tac      432
Leu Ser Ser Ser Ser Ser Gly His Ser Tyr Leu Gln Gln Ala Pro Tyr         
    130                 135                 140                         

tgg aca cac ccc caa cgc atg gag aag aaa ctg cac gcg gta cct gcc      480
Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala         
145                 150                 155                 160         

ggg aac act gtc aaa ttc cgc tgt cca gct gca ggg aac ccc atg ccc      528
Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met Pro         
                165                 170                 175             

acc atc cac tgg ctc aag aac gga cag gcc ttc cac gga gag aat cgt      576
Thr Ile His Trp Leu Lys Asn Gly Gln Ala Phe His Gly Glu Asn Arg         
            180                 185                 190                 

atc gga ggc att cgg ctg cgt cac caa cac tgg agc ctc gtg atg gag      624
Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu         
        195                 200                 205                     

agc gtg gtg ccc tca gac cgt ggc acg tac acg tgt ctt gtg gag aac      672
Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn         
    210                 215                 220                         

tct ctg ggt agc att cgc tac agc tat ctg ctg gat gtg ctg gag cgg      720
Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg         
225                 230                 235                 240         

tcc ccg cac cgg ccc atc ctg cag gcg gga ctc cca gcc aac acc acg      768
Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr         
                245                 250                 255             

gct gtg gtt ggc agc aac gtg gag ctg ctg tgc aag gtg tac agt gac      816
Ala Val Val Gly Ser Asn Val Glu Leu Leu Cys Lys Val Tyr Ser Asp         
            260                 265                 270                 

gcc cag ccg cac atc cag tgg ctg aag cac atc gtt atc aac ggc agc      864
Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser         
        275                 280                 285                     

agt ttc ggc gct gat ggt ttc ccc tac gta caa gtc ctg aag aca aca      912
Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Thr         
    290                 295                 300                         

gac atc aat agc tca gag gtg gag gtg ctg tat ctg agg aac gtg tcg      960
Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser         
305                 310                 315                 320         

gct gag gat gca ggg gag tac acc tgc ctg gcg ggc aac tcc atc ggc     1008
Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly         
                325                 330                 335             

ctc tcc tac cag tca gcg tgg ctc aca gtg cta ccc gca gag gaa gaa     1056
Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Ala Glu Glu Glu         
            340                 345                 350                 

gac ctc gcg tgg aca aca gca aca tcg gag gcc aga tat aca gat att     1104
Asp Leu Ala Trp Thr Thr Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile         
        355                 360                 365                     

atc cta tat gta tct ggc tca ctg gct ttg gtt ttg ctc ctg ctg ctg     1152
Ile Leu Tyr Val Ser Gly Ser Leu Ala Leu Val Leu Leu Leu Leu Leu         
    370                 375                 380                         

gcc ggg gtg tat cac cga caa gca atc cac ggc cac cac tct cga cag     1200
Ala Gly Val Tyr His Arg Gln Ala Ile His Gly His His Ser Arg Gln         
385                 390                 395                 400         

cct gtc act gta cag aag ctg tcc cgg ttc cct ttg gcc cgg cag ttc     1248
Pro Val Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe         
                405                 410                 415             

tcc ttg gag tcg agg tcc tct ggc aag tca agt ttg tcc ctg gtg cga     1296
Ser Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg         
            420                 425                 430                 

ggt gtc cgg ctc tcc tcc agt ggc ccg ccc ttg ctc acg ggc ctt gtg     1344
Gly Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val         
        435                 440                 445                     

agt cta gac cta cct ctc gat cca ctt tgg gag ttc ccc cgg gac agg     1392
Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg         
    450                 455                 460                         

ctg gtg ctc gga aag ccc ctg ggt gag ggc tgc ttt ggg caa gtg gtt     1440
Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val         
465                 470                 475                 480         

cgt gca gaa gcc ctt ggc atg gat tcc tcc cgg cca gac caa acc agc     1488
Arg Ala Glu Ala Leu Gly Met Asp Ser Ser Arg Pro Asp Gln Thr Ser         
                485                 490                 495             

acc gtg gct gtg aag atg ctg aaa gac aat gcc tcc gac aag gat ttg     1536
Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu         
            500                 505                 510                 

gca gac ctg atc tct gag atg gag atg atg aag cta atc gga aga cac     1584
Ala Asp Leu Ile Ser Glu Met Glu Met Met Lys Leu Ile Gly Arg His         
        515                 520                 525                     

aag aac atc att aac ctg ctg ggt gtc tgc act cag gaa ggg ccc ctg     1632
Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu         
    530                 535                 540                         

tat gtg att gtg gaa tat gcg gcc aag gga aac ctt cgg gaa ttc ctc     1680
Tyr Val Ile Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu         
545                 550                 555                 560         

cgt gcc cgg cgt ccc cca ggc cct gat ctc agc cct gat ggg cct cgg     1728
Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg         
                565                 570                 575             

agc agc gaa gga ccg ctc tcc ttc ccg gcc ctg gtc tcc tgt gcc tac     1776
Ser Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr         
            580                 585                 590                 

cag gtg gcc cga ggc atg cag tat ctg gag tct cgg aag tgc atc cac     1824
Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His         
        595                 600                 605                     

cgg gac ctg gct gcc cga aac gtg ctg gtg acc gag gat gac gtg atg     1872
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met         
    610                 615                 620                         

aag atc gct gac ttt ggt ctg gcc cgt ggt gtc cac cac atc gac tac     1920
Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr         
625                 630                 635                 640         

tat aag aaa acc agc aat ggc cgc ctg cca gtc aag tgg atg gct cct     1968
Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro         
                645                 650                 655             

gag gcg ttg ttt gac cgt gta tac aca cac cag agt gac gtg tgg tcc     2016
Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser         
            660                 665                 670                 

ttc ggg atc ctg ctg tgg gaa atc ttc acc ctc ggg ggc tcc cca tac     2064
Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr         
        675                 680                 685                     

ccc ggc atc cca gtg gag gag ctg ttc tca ctg ctg cga gag ggg cac     2112
Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His         
    690                 695                 700                         

agg atg gag cgg ccc cca aac tgc ccc tca gag ctg tat ggg cta atg     2160
Arg Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met         
705                 710                 715                 720         

agg gag tgt tgg cac gca gct cct tct cag agg ccg act ttt aag cag     2208
Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln         
                725                 730                 735             

ctg gtg gaa gct ctg gac aag gtc ctg ctg gct gtc tct gaa gag tac     2256
Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr         
            740                 745                 750                 

ctt gac ctc cgc ctg acc ttt gga ccc tat tcc ccc aac aat ggg gat     2304
Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp         
        755                 760                 765                     

gcc agc agc acg tgc tcc tcc agc gac tcg gtt ttc agc cac gac cct     2352
Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro         
    770                 775                 780                         

ttg ccc ctc gag cca agc ccc ttc cca ttt cct gag gcg cag acc aca     2400
Leu Pro Leu Glu Pro Ser Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr         
785                 790                 795                 800         

tga                                                                 2403


<210>  50
<211>  800
<212>  PRT
<213>  Rattus sp.

<400>  50

Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Glu Thr Pro Ala 
1               5                   10                  15      


Phe Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Pro Ala 
            20                  25                  30          


Pro Ile Ser Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              


Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  


Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  


Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      


Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         


Ile Met Asp Asp Ser Leu Pro Ser Ile Asn Asn Glu Asp Pro Lys Thr 
        115                 120                 125             


Leu Ser Ser Ser Ser Ser Gly His Ser Tyr Leu Gln Gln Ala Pro Tyr 
    130                 135                 140                 


Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala 
145                 150                 155                 160 


Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met Pro 
                165                 170                 175     


Thr Ile His Trp Leu Lys Asn Gly Gln Ala Phe His Gly Glu Asn Arg 
            180                 185                 190         


Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu 
        195                 200                 205             


Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn 
    210                 215                 220                 


Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg 
225                 230                 235                 240 


Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr 
                245                 250                 255     


Ala Val Val Gly Ser Asn Val Glu Leu Leu Cys Lys Val Tyr Ser Asp 
            260                 265                 270         


Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser 
        275                 280                 285             


Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Thr 
    290                 295                 300                 


Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser 
305                 310                 315                 320 


Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
                325                 330                 335     


Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Ala Glu Glu Glu 
            340                 345                 350         


Asp Leu Ala Trp Thr Thr Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile 
        355                 360                 365             


Ile Leu Tyr Val Ser Gly Ser Leu Ala Leu Val Leu Leu Leu Leu Leu 
    370                 375                 380                 


Ala Gly Val Tyr His Arg Gln Ala Ile His Gly His His Ser Arg Gln 
385                 390                 395                 400 


Pro Val Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe 
                405                 410                 415     


Ser Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg 
            420                 425                 430         


Gly Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val 
        435                 440                 445             


Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg 
    450                 455                 460                 


Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
465                 470                 475                 480 


Arg Ala Glu Ala Leu Gly Met Asp Ser Ser Arg Pro Asp Gln Thr Ser 
                485                 490                 495     


Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu 
            500                 505                 510         


Ala Asp Leu Ile Ser Glu Met Glu Met Met Lys Leu Ile Gly Arg His 
        515                 520                 525             


Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu 
    530                 535                 540                 


Tyr Val Ile Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu 
545                 550                 555                 560 


Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg 
                565                 570                 575     


Ser Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr 
            580                 585                 590         


Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His 
        595                 600                 605             


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met 
    610                 615                 620                 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr 
625                 630                 635                 640 


Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
                645                 650                 655     


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
            660                 665                 670         


Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
        675                 680                 685             


Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His 
    690                 695                 700                 


Arg Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met 
705                 710                 715                 720 


Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln 
                725                 730                 735     


Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr 
            740                 745                 750         


Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp 
        755                 760                 765             


Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro 
    770                 775                 780                 


Leu Pro Leu Glu Pro Ser Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr 
785                 790                 795                 800 


<210>  51
<211>  31
<212>  DNA
<213>  Mus sp.

<400>  51
cggccgccag gtacctggaa ttcggcttgg g                                    31


<210>  52
<211>  31
<212>  DNA
<213>  Mus sp.

<400>  52
ctagaaggca ctctagaggc tgatctcgag c                                    31


<210>  53
<211>  14
<212>  DNA
<213>  Mus sp.

<400>  53
cgagctctgt acaa                                                       14


<210>  54
<211>  22
<212>  DNA
<213>  Mus sp.

<400>  54
ctagttgtac agagctcggt ac                                              22


<210>  55
<211>  32
<212>  DNA
<213>  Mus sp.

<400>  55
gcgccgtcct ggagctcctg ctgctgaggt gg                                   32


<210>  56
<211>  24
<212>  DNA
<213>  Mus sp.

<400>  56
ggcaactaga aggcacagtc gagg                                            24


<210>  57
<211>  27
<212>  DNA
<213>  Mus sp.

<400>  57
gtccctggga tcctcgagga agtggag                                         27


<210>  58
<211>  31
<212>  DNA
<213>  Mus sp.

<400>  58
gcgcctgccc gagctccagc ccggccagca g                                    31


<210>  59
<211>  19
<212>  PRT
<213>  Mus sp.

<400>  59

Leu Ala Leu Ala Val Leu Leu Leu Ala Gly Leu Glu Leu Leu Leu Leu 
1               5                   10                  15      


Arg Trp Gln 
            


<210>  60
<211>  12
<212>  PRT
<213>  Mus sp.

<400>  60

Leu Ala Leu Ala Val Leu Leu Leu Leu Arg Trp Gln 
1               5                   10          


<210>  61
<211>  52
<212>  DNA
<213>  Mus sp.

<400>  61
ggccttggct gtgctcctgc tgctgaggtg gcagtttcct gcacactaca gg             52


<210>  62
<211>  52
<212>  DNA
<213>  Mus sp.

<400>  62
cctgtagtgt gcaggaaact gccacctcag cagcaggagc acagccaagg cc             52


<210>  63
<211>  23
<212>  DNA
<213>  Mus sp.

<400>  63
cgactggagc acgaggacac tga                                             23


<210>  64
<211>  21
<212>  DNA
<213>  Mus sp.

<400>  64
tatgcaaggc ttacaaccac a                                               21


<210>  65
<211>  24
<212>  DNA
<213>  Mus sp.

<400>  65
ctcattcctg ttgaagctct tgac                                            24


<210>  66
<211>  27
<212>  DNA
<213>  Mus sp.

<400>  66
acactcagca cgggacaaac tcttctc                                         27


<210>  67
<211>  27
<212>  DNA
<213>  Mus sp.

<400>  67
acactctgca ggagacagac tcttttc                                         27


<210>  68
<211>  1062
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1062)

<400>  68
ctg gag gcc tct gag gaa gtg gag ctt gag ccc tgc ctg gct ccc agc       48
Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser         
1               5                   10                  15              

ctg gag cag caa gag cag gag ctg aca gta gcc ctt ggg cag cct gtg       96
Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val         
            20                  25                  30                  

cgg ctg tgc tgt ggg cgg gct gag cgt ggt ggc cac tgg tac aag gag      144
Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly His Trp Tyr Lys Glu         
        35                  40                  45                      

ggc agt cgc ctg gca cct gct ggc cgt gta cgg ggc tgg agg ggc cgc      192
Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg Gly Trp Arg Gly Arg         
    50                  55                  60                          

cta gag att gcc agc ttc cta cct gag gat gct ggc cgc tac ctc tgc      240
Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys         
65                  70                  75                  80          

ctg gca cga ggc tcc atg atc gtc ctg cag aat ctc acc ttg att aca      288
Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr         
                85                  90                  95              

ggt gac tcc ttg acc tcc agc aac gat gat gag gac ccc aag tcc cat      336
Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu Asp Pro Lys Ser His         
            100                 105                 110                 

agg gac ctc tcg aat agg cac agt tac ccc cag caa gca ccc tac tgg      384
Arg Asp Leu Ser Asn Arg His Ser Tyr Pro Gln Gln Ala Pro Tyr Trp         
        115                 120                 125                     

aca cac ccc cag cgc atg gag aag aaa ctg cat gca gta cct gcg ggg      432
Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala Gly         
    130                 135                 140                         

aac acc gtc aag ttc cgc tgt cca gct gca ggc aac ccc acg ccc acc      480
Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr         
145                 150                 155                 160         

atc cgc tgg ctt aag gat gga cag gcc ttt cat ggg gag aac cgc att      528
Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile         
                165                 170                 175             

gga ggc att cgg ctg cgc cat cag cac tgg agt ctc gtg atg gag agc      576
Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu Ser         
            180                 185                 190                 

gtg gtg ccc tcg gac cgc ggc aca tac acc tgc ctg gta gag aac gct      624
Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala         
        195                 200                 205                     

gtg ggc agc atc cgt tat aac tac ctg cta gat gtg ctg gag cgg tcc      672
Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser         
    210                 215                 220                         

ccg cac cgg ccc atc ctg cag gcc ggg ctc ccg gcc aac acc aca gcc      720
Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala         
225                 230                 235                 240         

gtg gtg ggc agc gac gtg gag ctg ctg tgc aag gtg tac agc gat gcc      768
Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala         
                245                 250                 255             

cag ccc cac atc cag tgg ctg aag cac atc gtc atc aac ggc agc agc      816
Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser         
            260                 265                 270                 

ttc gga gcc gac ggt ttc ccc tat gtg caa gtc cta aag act gca gac      864
Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Ala Asp         
        275                 280                 285                     

atc aat agc tca gag gtg gag gtc ctg tac ctg cgg aac gtg tca gcc      912
Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala         
    290                 295                 300                         

gag gac gca ggc gag tac acc tgc ctc gca ggc aat tcc atc ggc ctc      960
Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu         
305                 310                 315                 320         

tcc tac cag tct gcc tgg ctc acg gtg cca gag gag gac ccc aca tgg     1008
Ser Tyr Gln Ser Ala Trp Leu Thr Val Pro Glu Glu Asp Pro Thr Trp         
                325                 330                 335             

acc gca gca gcg ccc gag gcc gct agc tgg agc cac ccg cag ttc gaa     1056
Thr Ala Ala Ala Pro Glu Ala Ala Ser Trp Ser His Pro Gln Phe Glu         
            340                 345                 350                 

aaa tga                                                             1062
Lys                                                                     
                                                                        


<210>  69
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  69

Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser 
1               5                   10                  15      


Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val 
            20                  25                  30          


Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly His Trp Tyr Lys Glu 
        35                  40                  45              


Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg Gly Trp Arg Gly Arg 
    50                  55                  60                  


Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys 
65                  70                  75                  80  


Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr 
                85                  90                  95      


Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu Asp Pro Lys Ser His 
            100                 105                 110         


Arg Asp Leu Ser Asn Arg His Ser Tyr Pro Gln Gln Ala Pro Tyr Trp 
        115                 120                 125             


Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala Gly 
    130                 135                 140                 


Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr 
145                 150                 155                 160 


Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg Ile 
                165                 170                 175     


Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu Ser 
            180                 185                 190         


Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala 
        195                 200                 205             


Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser 
    210                 215                 220                 


Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala 
225                 230                 235                 240 


Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala 
                245                 250                 255     


Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser 
            260                 265                 270         


Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Ala Asp 
        275                 280                 285             


Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala 
    290                 295                 300                 


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu 
305                 310                 315                 320 


Ser Tyr Gln Ser Ala Trp Leu Thr Val Pro Glu Glu Asp Pro Thr Trp 
                325                 330                 335     


Thr Ala Ala Ala Pro Glu Ala Ala Ser Trp Ser His Pro Gln Phe Glu 
            340                 345                 350         


Lys 
    


<210>  70
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
1               5                   10                  15      


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
            20                  25                  30          


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
        35                  40                  45              


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
    50                  55                  60                  


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
65                  70                  75                  80  


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
                85                  90                  95      


Val Leu 
        


<210>  71
<211>  648
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(648)

<400>  71
cag agc gaa ttg act cag cca ccc tca gcg tct ggg acc ccc ggg cag       48
Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln         
1               5                   10                  15              

agg gtc acc atc tct tgt tct gga ggc tac tcc aac atg gga agc aat       96
Arg Val Thr Ile Ser Cys Ser Gly Gly Tyr Ser Asn Met Gly Ser Asn         
            20                  25                  30                  

tat gca cac tgg tac cag cag ctc cca gga acg gcc ccc aaa ctc ctc      144
Tyr Ala His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu         
        35                  40                  45                      

atc tat aac aat aat cag cgg ccc tca ggg gtc cct gac cga ttc tct      192
Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser         
    50                  55                  60                          

ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cgg      240
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg         
65                  70                  75                  80          

tcc gag gat gag gct gat tat tac tgt gca gca tgg gat gac agc ctg      288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu         
                85                  90                  95              

agt ggt ccg gtg ttc ggc gga ggg acc aag ctg acc gtc cta ggt cag      336
Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln         
            100                 105                 110                 

ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct gag gag      384
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu         
        115                 120                 125                     

ctt caa gcc aac aag gcc aca ctg gtg tgt ctg atc agt gac ttc tac      432
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr         
    130                 135                 140                         

ccg gga gct gtg aca gtg gcc tgg aag gca gat ggc agc ccc gtc aag      480
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys         
145                 150                 155                 160         

gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac aag tac      528
Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr         
                165                 170                 175             

gcg gcc agc agc tat ctg agc ctg acg cct gag cag tgg aag tcc cac      576
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His         
            180                 185                 190                 

aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg gag aag      624
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys         
        195                 200                 205                     

aca gtg gcc cct aca gaa tgt tca                                      648
Thr Val Ala Pro Thr Glu Cys Ser                                         
    210                 215                                             


<210>  72
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Tyr Ser Asn Met Gly Ser Asn 
            20                  25                  30          


Tyr Ala His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  73
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  73

Ser Asn Met Gly Ser Asn Tyr Ala His 
1               5                   


<210>  74
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  74

Tyr Asn Asn Asn Gln 
1               5   


<210>  75
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Trp Asp Asp Ser Leu Ser Gly 
1               5               


<210>  76
<211>  411
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(411)

<400>  76
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt       48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct cct tac       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr         
            20                  25                  30                  

tgg atg ggt tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt      144
Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

tct gtt atc tgg cct tct ggt ggc act act gat tat gct gac tcc gtt      192
Ser Val Ile Trp Pro Ser Gly Gly Thr Thr Asp Tyr Ala Asp Ser Val         
    50                  55                  60                          

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gtc cat cca gct ggc cac aac gac cac tgg ggc cag gga acc      336
Ala Arg Val His Pro Ala Gly His Asn Asp His Trp Gly Gln Gly Thr         
            100                 105                 110                 

ctg gtc acc gtc tca agc gcc tcc acc aag ggc cca tcg gtc ttc ccg      384
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro         
        115                 120                 125                     

cta gca ccc tcc tcc aag agc acc tct                                  411
Leu Ala Pro Ser Ser Lys Ser Thr Ser                                     
    130                 135                                             


<210>  77
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  77

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Trp Pro Ser Gly Gly Thr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val His Pro Ala Gly His Asn Asp His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135         


<210>  78
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  78

Phe Thr Phe Ser Pro Tyr Trp Met Gly 
1               5                   


<210>  79
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  79

Val Ile Trp Pro Ser Gly Gly Thr Thr Asp 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  80

Arg Val His Pro Ala Gly His Asn Asp His 
1               5                   10  


<210>  81
<211>  645
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(645)

<400>  81
caa gac atc cag atg acc cag tct cca tcc tcc ctg tct ttg tct cca       48
Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Leu Ser Pro         
1               5                   10                  15              

ggg gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt att aac aga       96
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Arg         
            20                  25                  30                  

aac tta ggc tgg tac cag cag aag cct ggc cag gct ccc agg ctc ctc      144
Asn Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu         
        35                  40                  45                      

atc tat ggt gcg tcc acc agg gcc act ggt atc cca gcc agg ttc act      192
Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Thr         
    50                  55                  60                          

ggc agt ggg tct ggg aca gag ttc tct ctc acc atc agc agc ctg cag      240
Gly Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln         
65                  70                  75                  80          

tct gaa gat tat gca att tat tat tgt cag cag tat gat aac tgg ccg      288
Ser Glu Asp Tyr Ala Ile Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro         
                85                  90                  95              

atc atc ttc ggc caa ggg aca cga ctg gag att aaa gga act gtg gct      336
Ile Ile Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Thr Val Ala         
            100                 105                 110                 

gca cca tct gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct      384
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser         
        115                 120                 125                     

gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag      432
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu         
    130                 135                 140                         

gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc      480
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser         
145                 150                 155                 160         

cag gag agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc      528
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu         
                165                 170                 175             

agc agc acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc      576
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val         
            180                 185                 190                 

tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag      624
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys         
        195                 200                 205                     

agc ttc aac agg gga gag tgt                                          645
Ser Phe Asn Arg Gly Glu Cys                                             
    210                 215                                             


<210>  82
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Arg 
            20                  25                  30          


Asn Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Thr 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Tyr Ala Ile Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro 
                85                  90                  95      


Ile Ile Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  83
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  83

Ser Ile Asn Arg Asn Leu Gly 
1               5           


<210>  84
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  84

Tyr Gly Ala Ser Thr 
1               5   


<210>  85
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  85

Gln Tyr Asp Asn Trp Pro 
1               5       


<210>  86
<211>  411
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(411)

<400>  86
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt       48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct cgt tac       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr         
            20                  25                  30                  

ttt atg aag tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt      144
Phe Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

tct tgg atc tct cct tct ggt ggc ctt act gag tat gct gac tcc gtt      192
Ser Trp Ile Ser Pro Ser Gly Gly Leu Thr Glu Tyr Ala Asp Ser Val         
    50                  55                  60                          

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcc aga gcc tca tac ggt gcc tgg ctg gac tac tgg ggc cag ggc acc      336
Ala Arg Ala Ser Tyr Gly Ala Trp Leu Asp Tyr Trp Gly Gln Gly Thr         
            100                 105                 110                 

ctg gtc acc gtc tca agc gcc tcc acc aag ggc cca tcg gtc ttc ccg      384
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro         
        115                 120                 125                     

cta gca ccc tcc tcc aag agc acc tct                                  411
Leu Ala Pro Ser Ser Lys Ser Thr Ser                                     
    130                 135                                             


<210>  87
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Phe Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Pro Ser Gly Gly Leu Thr Glu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Tyr Gly Ala Trp Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135         


<210>  88
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  88

Phe Thr Phe Ser Arg Tyr Phe Met Lys 
1               5                   


<210>  89
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  89

Trp Ile Ser Pro Ser Gly Gly Leu Thr Glu 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  90

Arg Ala Ser Tyr Gly Ala Trp Leu Asp Tyr 
1               5                   10  


<210>  91
<211>  651
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(651)

<400>  91
cag agc gtc ttg act cag cca ccc tca gcg tct ggg acc ccc ggc cag       48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln         
1               5                   10                  15              

ggg gtc acc atc tct tgt tct gga agc agc tcc aac atc gga agt aat       96
Gly Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn         
            20                  25                  30                  

agt gtt aac tgg tac cag cag ctc cca gga gcg gcc ccc aaa ctc ctc      144
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu         
        35                  40                  45                      

atc tat agt aac aat ctg cgg ccc tca ggg gtc cct gcc cga ttc tct      192
Ile Tyr Ser Asn Asn Leu Arg Pro Ser Gly Val Pro Ala Arg Phe Ser         
    50                  55                  60                          

ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggc ctc cgg      240
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg         
65                  70                  75                  80          

tct gag gat gag gct gat tat tac tgt gca gcc tgg gat gac ggc ctg      288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Gly Leu         
                85                  90                  95              

gat gcc tat gtg gtg ttc ggc gga ggg acc aaa ctg acc gtc ctg ggt      336
Asp Ala Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly         
            100                 105                 110                 

cag ccc aag gcc aac ccc act gtc act ctg ttc ccg ccc tcc tct gag      384
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu         
        115                 120                 125                     

gag ctc caa gcc aac aag gcc aca cta gtg tgt ctg atc agt gac ttc      432
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe         
    130                 135                 140                         

tac ccg gga gct gtg aca gtg gcc tgg aag gca gat ggc agc ccc gtc      480
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val         
145                 150                 155                 160         

aag gcg gga gtg gag acc acc aaa ccc tcc aaa cag agc aac aac aag      528
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys         
                165                 170                 175             

tac gcg gcc agc agc tac ctg agc ctg acg ccc gag cag tgg aag tcc      576
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser         
            180                 185                 190                 

cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg gag      624
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu         
        195                 200                 205                     

aag aca gtg gcc cct gca gaa tgc tct                                  651
Lys Thr Val Ala Pro Ala Glu Cys Ser                                     
    210                 215                                             


<210>  92
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Gly Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Leu Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Gly Leu 
                85                  90                  95      


Asp Ala Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Ala Glu Cys Ser 
    210                 215         


<210>  93
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  93

Ser Asn Ile Gly Ser Asn Ser Val Asn 
1               5                   


<210>  94
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  94

Tyr Ser Asn Asn Leu 
1               5   


<210>  95
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  95

Ala Trp Asp Asp Gly Leu Asp Ala Tyr 
1               5                   


<210>  96
<211>  414
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(414)

<400>  96
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt       48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct act tac       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr         
            20                  25                  30                  

tgg atg gct tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt      144
Trp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

tct gtt atc ggt cct tct ggt ggc atg act gtt tat gct gac tcc gtt      192
Ser Val Ile Gly Pro Ser Gly Gly Met Thr Val Tyr Ala Asp Ser Val         
    50                  55                  60                          

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gca cgg att aat agt ggg agc tcc cac ttt gac tac tgg ggc cag gga      336
Ala Arg Ile Asn Ser Gly Ser Ser His Phe Asp Tyr Trp Gly Gln Gly         
            100                 105                 110                 

acc ctg gtc acc gtc tca agc gcc tcc acc aag ggc cca tcg gtc ttc      384
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe         
        115                 120                 125                     

ccg cta gca ccc tcc tcc aag agc acc tct                              414
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser                                 
    130                 135                                             


<210>  97
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  97

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Gly Pro Ser Gly Gly Met Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Asn Ser Gly Ser Ser His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135             


<210>  98
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  98

Phe Thr Phe Ser Thr Tyr Trp Met Ala 
1               5                   


<210>  99
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  99

Val Ile Gly Pro Ser Gly Gly Met Thr Val 
1               5                   10  


<210>  100
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  100

Arg Ile Asn Ser Gly Ser Ser His Phe Asp Tyr 
1               5                   10      


<210>  101
<211>  651
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(651)

<400>  101
cag tac gaa ttg act cag cca ccc tca gcg tct ggg acc ccc ggg cag       48
Gln Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln         
1               5                   10                  15              

agg gtc acc atc tct tgt tct gga agc agc tcc aac atc gga agc aat       96
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn         
            20                  25                  30                  

att gta cac tgg tac cag cag ctc cca gga acg gcc ccc aaa ctc ctc      144
Ile Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu         
        35                  40                  45                      

ata tat ggt aat aat cag cgg ccc tca ggg gtc cct gac cga ttc tct      192
Ile Tyr Gly Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser         
    50                  55                  60                          

gtc tcc aag tct ggc tcc tca gcc tcc ctg gcc atc agt ggg ctc cag      240
Val Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln         
65                  70                  75                  80          

tct gag gat gag gct gat tat tac tgt gca tca tgg gat gac agc ctg      288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu         
                85                  90                  95              

aaa gcc ttt tat gtc ttc gga act ggg acc aag gtc acc gtc cta ggt      336
Lys Ala Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly         
            100                 105                 110                 

cag ccc aag gcc aac ccc act gtc act ctg ttc ccg ccc tcc tct gag      384
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu         
        115                 120                 125                     

gag ctc caa gcc aac aag gcc aca cta gtg tgt ctg atc agt gac ttc      432
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe         
    130                 135                 140                         

tac ccg gga gct gtg aca gtg gcc tgg aag gca gat ggc agc ccc gtc      480
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val         
145                 150                 155                 160         

aag gcg gga gtg gag acc acc aaa ccc tcc aaa cag agc aac aac aag      528
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys         
                165                 170                 175             

tac gcg gcc agc agc tac ctg agc ctg acg ccc gag cag tgg aag tcc      576
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser         
            180                 185                 190                 

cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg gag      624
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu         
        195                 200                 205                     

aag aca gtg gcc cct aca gaa tgt tca                                  651
Lys Thr Val Ala Pro Thr Glu Cys Ser                                     
    210                 215                                             


<210>  102
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  102

Gln Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ile Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Val Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Lys Ala Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  103
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  103

Ser Asn Ile Gly Ser Asn Ile Val His 
1               5                   


<210>  104
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  104

Tyr Gly Asn Asn Gln 
1               5   


<210>  105
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  105

Ser Trp Asp Asp Ser Leu Lys Ala Phe 
1               5                   


<210>  106
<211>  420
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(420)

<400>  106
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt       48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly         
1               5                   10                  15              

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct cat tac       96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr         
            20                  25                  30                  

tgg atg ggt tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt      144
Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val         
        35                  40                  45                      

tct gtt atc tct cct tct ggt ggc ctt act att tat gct gac tcc gtt      192
Ser Val Ile Ser Pro Ser Gly Gly Leu Thr Ile Tyr Ala Asp Ser Val         
    50                  55                  60                          

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac      240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr         
65                  70                  75                  80          

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt      288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gca cgg agc agt ggc tgg gct ctg gat gct ttt gat atc tgg ggc caa      336
Ala Arg Ser Ser Gly Trp Ala Leu Asp Ala Phe Asp Ile Trp Gly Gln         
            100                 105                 110                 

ggg aca atg gtc acc gtc tca agc gcc tcc acc aag ggc cca tcg gtc      384
Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val         
        115                 120                 125                     

ttc ccg cta gca ccc tcc tcc aag agc acc tct ggg                      420
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly                         
    130                 135                 140                         


<210>  107
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  107

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Leu Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Gly Trp Ala Leu Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140 


<210>  108
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  108

Phe Thr Phe Ser His Tyr Trp Met Gly 
1               5                   


<210>  109
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  109

Val Ile Ser Pro Ser Gly Gly Leu Thr Ile 
1               5                   10  


<210>  110
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  110

Arg Ser Ser Gly Trp Ala Leu Asp Ala Phe Asp Ile 
1               5                   10          


<210>  111
<211>  1215
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1215)

<400>  111
atg cgg ctg ctg ctg gcc ctg ttg ggg gtc ctg ctg agt gtg cct ggg       48
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly         
1               5                   10                  15              

cct cca gtc ttg tcc ctg gag gcc tct gag gaa gtg gag ctt gag ccc       96
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro         
            20                  25                  30                  

tgc ctg gct ccc agc ctg gag cag caa gag cag gag ctg aca gta gcc      144
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala         
        35                  40                  45                      

ctt ggg cag cct gtg cgg ctg tgc tgt ggg cgg gct gag cgt ggt ggc      192
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly         
    50                  55                  60                          

cac tgg tac aag gag ggc agt cgc ctg gca cct gct ggc cgt gta cgg      240
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg         
65                  70                  75                  80          

ggc tgg agg ggc cgc cta gag att gcc agc ttc cta cct gag gat gct      288
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala         
                85                  90                  95              

ggc cgc tac ctc tgc ctg gca cga ggc tcc atg atc gtc ctg cag aat      336
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn         
            100                 105                 110                 

ctc acc ttg att aca ggt gac tcc ttg acc tcc agc aac gat gat gag      384
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu         
        115                 120                 125                     

gac ccc aag tcc cat agg gac ctc tcg aat agg cac agt tac ccc cag      432
Asp Pro Lys Ser His Arg Asp Leu Ser Asn Arg His Ser Tyr Pro Gln         
    130                 135                 140                         

caa gca ccc tac tgg aca cac ccc cag cgc atg gag aag aaa ctg cat      480
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His         
145                 150                 155                 160         

gca gta cct gcg ggg aac acc gtc aag ttc cgc tgt cca gct gca ggc      528
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly         
                165                 170                 175             

aac ccc acg aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc      576
Asn Pro Thr Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu         
            180                 185                 190                 

ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc      624
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr         
        195                 200                 205                     

ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg      672
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val         
    210                 215                 220                         

agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg      720
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val         
225                 230                 235                 240         

gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc      768
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser         
                245                 250                 255             

acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg      816
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu         
            260                 265                 270                 

aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc      864
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala         
        275                 280                 285                     

ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca      912
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro         
    290                 295                 300                         

cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag      960
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln         
305                 310                 315                 320         

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc     1008
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala         
                325                 330                 335             

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg     1056
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr         
            340                 345                 350                 

cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc     1104
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu         
        355                 360                 365                     

acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc     1152
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser         
    370                 375                 380                         

gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc     1200
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser         
385                 390                 395                 400         

ctg tct ccg ggt tga                                                 1215
Leu Ser Pro Gly                                                         
                                                                        


<210>  112
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Leu Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        275                 280                 285             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
305                 310                 315                 320 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser Pro Gly 
                


<210>  113
<211>  1068
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1068)

<400>  113
atg cgg ctg ctg ctg gcc ctg ttg ggg gtc ctg ctg agt gtg cct ggg       48
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly         
1               5                   10                  15              

cct cca gtc ttg tcc ctg gag gcc tct gag gaa gtg gag ctt gag ccc       96
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro         
            20                  25                  30                  

caa gca ccc tac tgg aca cac ccc cag cgc atg gag aag aaa ctg cat      144
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His         
        35                  40                  45                      

gca gta cct gcg ggg aac acc gtc aag ttc cgc tgt cca gct gca ggc      192
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly         
    50                  55                  60                          

aac ccc acg ccc acc atc cgc tgg ctt aag gat gga cag gcc ttt cat      240
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His         
65                  70                  75                  80          

ggg gag aac cgc att gga ggc att cgg ctg cgc cat cag cac tgg agt      288
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser         
                85                  90                  95              

ctc gtg atg gag agc gtg gtg ccc tcg gac cgc ggc aca tac acc tgc      336
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys         
            100                 105                 110                 

ctg gta gag aac gct gtg ggc agc atc cgt tat aac tac ctg cta gat      384
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp         
        115                 120                 125                     

gtg ctg aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg      432
Val Leu Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu         
    130                 135                 140                         

ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc      480
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu         
145                 150                 155                 160         

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc      528
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser         
                165                 170                 175             

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag      576
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu         
            180                 185                 190                 

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg      624
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr         
        195                 200                 205                     

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat      672
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn         
    210                 215                 220                         

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc      720
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro         
225                 230                 235                 240         

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag      768
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln         
                245                 250                 255             

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc      816
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val         
            260                 265                 270                 

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg      864
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val         
        275                 280                 285                     

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct      912
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro         
    290                 295                 300                         

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc      960
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr         
305                 310                 315                 320         

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg     1008
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val         
                325                 330                 335             

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg     1056
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu         
            340                 345                 350                 

tct ccg ggt tga                                                     1068
Ser Pro Gly                                                             
        355                                                             


<210>  114
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
        35                  40                  45              


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
    50                  55                  60                  


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
65                  70                  75                  80  


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
                85                  90                  95      


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
            100                 105                 110         


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
        115                 120                 125             


Val Leu Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly 
        355 


<210>  115
<211>  1188
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1188)

<400>  115
atg cgg ctg ctg ctg gcc ctg ttg ggg gtc ctg ctg agt gtg cct ggg       48
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly         
1               5                   10                  15              

cct cca gtc ttg tcc ctg gag gcc tct gag gaa gtg gag ctt gag ccc       96
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro         
            20                  25                  30                  

aac gct gtg ggc agc atc cgt tat aac tac ctg cta gat gtg ctg gag      144
Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu         
        35                  40                  45                      

cgg tcc ccg cac cgg ccc atc ctg cag gcc ggg ctc ccg gcc aac acc      192
Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr         
    50                  55                  60                          

aca gcc gtg gtg ggc agc gac gtg gag ctg ctg tgc aag gtg tac agc      240
Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser         
65                  70                  75                  80          

gat gcc cag ccc cac atc cag tgg ctg aag cac atc gtc atc aac ggc      288
Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly         
                85                  90                  95              

agc agc ttc gga gcc gac ggt ttc ccc tat gtg caa gtc cta aag act      336
Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr         
            100                 105                 110                 

gca gac atc aat agc tca gag gtg gag gtc ctg tac ctg cgg aac gtg      384
Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val         
        115                 120                 125                     

tca gcc gag gac gca ggc gag tac acc tgc ctc gca ggc aat tcc atc      432
Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile         
    130                 135                 140                         

ggc ctc tcc tac cag tct gcc tgg ctc acg gtg ctg cca gag gag gac      480
Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp         
145                 150                 155                 160         

ccc aca tgg acc gca gca gcg ccc gag gcc aaa act cac aca tgc cca      528
Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Lys Thr His Thr Cys Pro         
                165                 170                 175             

ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc      576
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe         
            180                 185                 190                 

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc      624
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val         
        195                 200                 205                     

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc      672
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe         
    210                 215                 220                         

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg      720
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro         
225                 230                 235                 240         

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc      768
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr         
                245                 250                 255             

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc      816
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val         
            260                 265                 270                 

tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc      864
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala         
        275                 280                 285                     

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg      912
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg         
    290                 295                 300                         

gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc      960
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly         
305                 310                 315                 320         

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg     1008
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro         
                325                 330                 335             

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc     1056
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser         
            340                 345                 350                 

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag     1104
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln         
        355                 360                 365                     

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac     1152
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His         
    370                 375                 380                         

tac acg cag aag agc ctc tcc ctg tct ccg ggt tga                     1188
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                             
385                 390                 395                             


<210>  116
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu Glu 
        35                  40                  45              


Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr 
    50                  55                  60                  


Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser 
65                  70                  75                  80  


Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly 
                85                  90                  95      


Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr 
            100                 105                 110         


Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val 
        115                 120                 125             


Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
    130                 135                 140                 


Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp 
145                 150                 155                 160 


Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Lys Thr His Thr Cys Pro 
                165                 170                 175     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            180                 185                 190         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        195                 200                 205             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    210                 215                 220                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
225                 230                 235                 240 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                245                 250                 255     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            260                 265                 270         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        275                 280                 285             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    290                 295                 300                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
305                 310                 315                 320 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                325                 330                 335     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            340                 345                 350         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        355                 360                 365             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    370                 375                 380                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395 


<210>  117
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  117

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


