                                SEQUENCE LISTING


<110> SOCPRA-SCIENCES ET GNIE S.E.C.
      Robert DAY
      Martin FUGRE
      Witold A. NEUGEBAUER

<120> MULTI-LEU PEPTIDES AND ANALOGUES THEREOF
      AS SELECTIVE PACE4 INHIBITORS AND EFFECTIVE
      ANTIPROLIFERATIVE AGENTS

<130> 15792901

<150> US 61/079820
<151> 2008-07-11

<160> 29

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 1
Arg Val Lys Arg
 1              


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 2
Leu Arg Val Lys Arg
 1               5  


<210> 3
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 3
Leu Leu Arg Val Lys Arg
 1               5      


<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 4
Leu Leu Leu Arg Val Lys Arg
 1               5          


<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 5
Leu Leu Leu Leu Arg Val Lys Arg
 1               5              


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 6
Leu Leu Leu Leu Leu Arg Val Lys Arg
 1               5                  


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 7
Leu Leu Leu Leu Leu Leu Arg Val Lys Arg
 1               5                  10  


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 8
caagagaccc aggagcatcc c                                           21

<210> 9
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 9
acccgctggt ccgagtgct                                              19

<210> 10
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 10
atccatcggg taccgggcca gctagtttgg cctctgctac caaccagggt ccacc      55

<210> 11
<211> 74
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 11
ccagctagaa agggtccctt agccatccgc gaacggatgc ccaatcaaca ccgcgaggag 60
gtggaccctg gttg                                                   74

<210> 12
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 12
ttaatacgac tcactataca aaaaccaact ttggtacc                         38

<210> 13
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 13
ttaatacgac tcactatagg gccagctagt tt                               32

<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 14
ccagctagaa agggtccctt a                                           21

<210> 15
<211> 260
<212> PRT
<213> Human

<220> 
<223> proSAAS

<400> 15
Met Ala Gly Ser Pro Leu Leu Trp Gly Pro Arg Ala Gly Gly Val Gly
 1               5                  10                  15      
Leu Leu Val Leu Leu Leu Leu Gly Leu Phe Arg Pro Pro Pro Ala Leu
            20                  25                  30          
Cys Ala Arg Pro Val Lys Glu Pro Arg Gly Leu Ser Ala Ala Ser Pro
        35                  40                  45              
Pro Leu Ala Glu Thr Gly Ala Pro Arg Arg Phe Arg Arg Ser Val Pro
    50                  55                  60                  
Arg Gly Glu Ala Ala Gly Ala Val Gln Glu Leu Ala Arg Ala Leu Ala
65                  70                  75                  80  
His Leu Leu Glu Ala Glu Arg Gln Glu Arg Ala Arg Ala Glu Ala Gln
                85                  90                  95      
Glu Ala Glu Asp Gln Gln Ala Arg Val Leu Ala Gln Leu Leu Arg Val
            100                 105                 110         
Trp Gly Ala Pro Arg Asn Ser Asp Pro Ala Leu Gly Leu Asp Asp Asp
        115                 120                 125             
Pro Asp Ala Pro Ala Ala Gln Leu Ala Arg Ala Leu Leu Arg Ala Arg
    130                 135                 140                 
Leu Asp Pro Ala Ala Leu Ala Ala Gln Leu Val Pro Ala Pro Val Pro
145                 150                 155                 160 
Ala Ala Ala Leu Arg Pro Arg Pro Pro Val Tyr Asp Asp Gly Pro Ala
                165                 170                 175     
Gly Pro Asp Ala Glu Glu Ala Gly Asp Glu Thr Pro Asp Val Asp Pro
            180                 185                 190         
Glu Leu Leu Arg Tyr Leu Leu Gly Arg Ile Leu Ala Gly Ser Ala Asp
        195                 200                 205             
Ser Glu Gly Val Ala Ala Pro Arg Arg Leu Arg Arg Ala Ala Asp His
    210                 215                 220                 
Asp Val Gly Ser Glu Leu Pro Pro Glu Gly Val Leu Gly Ala Leu Leu
225                 230                 235                 240 
Arg Val Lys Arg Leu Glu Thr Pro Ala Pro Gln Val Pro Ala Arg Arg
                245                 250                 255     
Leu Leu Pro Pro
            260 


<210> 16
<211> 31
<212> PRT
<213> Human

<220> 
<223> C-terminal of 7B2

<400> 16
Ser Val Asn Pro Tyr Leu Gln Gly Gln Arg Leu Asp Asn Val Val Ala
 1               5                  10                  15      
Lys Lys Ser Val Pro His Phe Ser Asp Glu Asp Lys Asp Pro Glu
            20                  25                  30      


<210> 17
<211> 913
<212> PRT
<213> Human

<220> 
<223> PC5/6

<400> 17
Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu
 1               5                  10                  15      
Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr
            20                  25                  30          
Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro
        35                  40                  45              
Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln
    50                  55                  60                  
Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile
65                  70                  75                  80  
Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met
                85                  90                  95      
Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr
            100                 105                 110         
Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp
        115                 120                 125             
Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His
    130                 135                 140                 
Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr
145                 150                 155                 160 
Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg
                165                 170                 175     
Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp
            180                 185                 190         
Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn
        195                 200                 205             
Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala
    210                 215                 220                 
Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly
225                 230                 235                 240 
Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys
                245                 250                 255     
Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp
            260                 265                 270         
Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr
        275                 280                 285             
Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly
    290                 295                 300                 
Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His
305                 310                 315                 320 
Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser
                325                 330                 335     
Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser
            340                 345                 350         
Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys
        355                 360                 365             
Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly
    370                 375                 380                 
Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu
385                 390                 395                 400 
Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val
                405                 410                 415     
Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn
            420                 425                 430         
Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp
        435                 440                 445             
Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg
    450                 455                 460                 
Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg
465                 470                 475                 480 
Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp
                485                 490                 495     
Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile
            500                 505                 510         
Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser
        515                 520                 525             
Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His
    530                 535                 540                 
Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp
545                 550                 555                 560 
Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro
                565                 570                 575     
Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser
            580                 585                 590         
Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu
        595                 600                 605             
Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr
    610                 615                 620                 
Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys
625                 630                 635                 640 
Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys
                645                 650                 655     
Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser
            660                 665                 670         
Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys
        675                 680                 685             
Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys
    690                 695                 700                 
Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys
705                 710                 715                 720 
Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu
                725                 730                 735     
Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn
            740                 745                 750         
Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser
        755                 760                 765             
Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro
    770                 775                 780                 
Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys
785                 790                 795                 800 
Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln
                805                 810                 815     
Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr
            820                 825                 830         
Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro
        835                 840                 845             
Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu
    850                 855                 860                 
Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Ala Thr Glu Glu Ser
865                 870                 875                 880 
Trp Ala Glu Gly Gly Phe Cys Met Leu Val Lys Lys Asn Asn Leu Cys
                885                 890                 895     
Gln Arg Lys Val Leu Gln Gln Leu Cys Cys Lys Thr Cys Thr Phe Gln
            900                 905                 910         
Gly
    


<210> 18
<211> 784
<212> PRT
<213> Human

<220> 
<223> PC7

<400> 18
Met Pro Lys Gly Arg Gln Lys Val Pro His Leu Asp Ala Pro Leu Gly
 1               5                  10                  15      
Leu Pro Thr Cys Leu Trp Leu Glu Leu Ala Gly Leu Phe Leu Leu Val
            20                  25                  30          
Pro Trp Val Met Gly Leu Ala Gly Thr Gly Gly Pro Asp Gly Gln Gly
        35                  40                  45              
Thr Gly Gly Pro Ser Trp Ala Val His Leu Glu Ser Leu Glu Gly Asp
    50                  55                  60                  
Gly Glu Glu Glu Thr Leu Glu Gln Gln Ala Asp Ala Leu Ala Gln Ala
65                  70                  75                  80  
Ala Gly Leu Val Asn Ala Gly Arg Ile Gly Glu Leu Gln Gly His Tyr
                85                  90                  95      
Leu Phe Val Gln Pro Ala Gly His Arg Pro Ala Leu Glu Val Glu Ala
            100                 105                 110         
Ile Arg Gln Gln Val Glu Ala Val Leu Ala Gly His Glu Ala Val Arg
        115                 120                 125             
Trp His Ser Glu Gln Arg Leu Leu Arg Arg Ala Lys Arg Ser Val His
    130                 135                 140                 
Phe Asn Asp Pro Lys Tyr Pro Gln Gln Trp His Leu Asn Asn Arg Arg
145                 150                 155                 160 
Ser Pro Gly Arg Asp Ile Asn Val Thr Gly Val Trp Glu Arg Asn Val
                165                 170                 175     
Thr Gly Arg Gly Val Thr Val Val Val Val Asp Asp Gly Val Glu His
            180                 185                 190         
Thr Ile Gln Asp Ile Ala Pro Asn Tyr Ser Pro Glu Gly Ser Tyr Asp
        195                 200                 205             
Leu Asn Ser Asn Asp Pro Asp Pro Met Pro His Pro Asp Val Glu Asn
    210                 215                 220                 
Gly Asn His His Gly Thr Arg Cys Ala Gly Glu Ile Ala Ala Val Pro
225                 230                 235                 240 
Asn Asn Ser Phe Cys Ala Val Gly Val Ala Tyr Gly Ser Arg Ile Ala
                245                 250                 255     
Gly Ile Arg Val Leu Asp Gly Pro Leu Thr Asp Ser Met Glu Ala Val
            260                 265                 270         
Ala Phe Asn Lys His Tyr Gln Ile Asn Asp Ile Tyr Ser Cys Ser Trp
        275                 280                 285             
Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro His Gln Leu Gly
    290                 295                 300                 
Lys Ala Ala Leu Gln His Gly Val Ile Ala Gly Arg Gln Gly Phe Gly
305                 310                 315                 320 
Ser Ile Phe Val Val Ala Ser Gly Asn Gly Gly Gln His Asn Asp Asn
                325                 330                 335     
Cys Asn Tyr Asp Gly Tyr Ala Asn Ser Ile Tyr Thr Val Thr Ile Gly
            340                 345                 350         
Ala Val Asp Glu Glu Gly Arg Met Pro Phe Tyr Ala Glu Glu Cys Ala
        355                 360                 365             
Ser Met Leu Ala Val Thr Phe Ser Gly Gly Asp Lys Met Leu Arg Ser
    370                 375                 380                 
Ile Val Thr Thr Asp Trp Asp Leu Gln Lys Gly Thr Gly Cys Thr Glu
385                 390                 395                 400 
Gly His Thr Gly Thr Ser Ala Ala Ala Pro Leu Ala Ala Gly Met Ile
                405                 410                 415     
Ala Leu Met Leu Gln Val Arg Pro Cys Leu Thr Trp Arg Asp Val Gln
            420                 425                 430         
His Ile Ile Val Phe Thr Ala Thr Arg Tyr Glu Asp Arg Arg Ala Glu
        435                 440                 445             
Trp Val Thr Asn Glu Ala Gly Phe Ser His Ser His Gln His Gly Phe
    450                 455                 460                 
Gly Leu Leu Asn Ala Trp Arg Leu Val Asn Ala Ala Lys Ile Trp Thr
465                 470                 475                 480 
Ser Val Pro Tyr Leu Ala Ser Tyr Val Ser Pro Val Leu Lys Glu Asn
                485                 490                 495     
Lys Ala Ile Pro Gln Ser Pro Arg Ser Leu Glu Val Leu Trp Asn Val
            500                 505                 510         
Ser Arg Met Asp Leu Glu Met Gly Leu Lys Thr Leu Glu His Val Ala
        515                 520                 525             
Val Thr Val Ser Ile Thr His Pro Arg Arg Gly Ser Leu Glu Leu Lys
    530                 535                 540                 
Leu Phe Cys Pro Ser Gly Met Met Ser Leu Ile Gly Ala Pro Arg Ser
545                 550                 555                 560 
Met Asp Ser Asp Pro Asn Gly Phe Asn Asp Trp Thr Phe Ser Thr Val
                565                 570                 575     
Arg Cys Trp Gly Glu Arg Ala Arg Gly Thr Tyr Arg Leu Val Ile Arg
            580                 585                 590         
Asp Val Gly Asp Glu Ser Phe Gln Val Gly Ile Leu Arg Gln Trp Gln
        595                 600                 605             
Leu Thr Leu Tyr Gly Ser Val Trp Ser Ala Val Asp Ile Arg Asp Arg
    610                 615                 620                 
Gln Arg Leu Leu Glu Ser Ala Met Ser Gly Lys Tyr Leu His Asp Asp
625                 630                 635                 640 
Phe Ala Leu Pro Cys Pro Pro Gly Leu Lys Ile Pro Glu Glu Asp Gly
                645                 650                 655     
Tyr Thr Ile Thr Pro Asn Thr Leu Lys Thr Leu Val Leu Val Gly Cys
            660                 665                 670         
Phe Thr Val Phe Trp Thr Val Tyr Tyr Met Leu Glu Val Tyr Leu Ser
        675                 680                 685             
Gln Arg Asn Val Ala Ser Asn Gln Val Cys Arg Ser Gly Pro Cys His
    690                 695                 700                 
Trp Pro His Arg Ser Arg Lys Ala Lys Glu Glu Gly Thr Glu Leu Glu
705                 710                 715                 720 
Ser Val Pro Leu Cys Ser Ser Lys Asp Pro Asp Glu Val Glu Thr Glu
                725                 730                 735     
Ser Arg Gly Pro Pro Thr Thr Ser Asp Leu Leu Ala Pro Asp Leu Leu
            740                 745                 750         
Glu Gln Gly Asp Trp Ser Leu Ser Gln Asn Lys Ser Ala Leu Asp Cys
        755                 760                 765             
Pro His Gln His Leu Asp Val Pro His Gly Lys Glu Glu Gln Ile Cys
    770                 775                 780                 


<210> 19
<211> 794
<212> PRT
<213> Human

<220> 
<223> Furin

<400> 19
Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr
 1               5                  10                  15      
Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn
            20                  25                  30          
Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val
        35                  40                  45              
Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr
    50                  55                  60                  
Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His
65                  70                  75                  80  
Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu
                85                  90                  95      
Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu
            100                 105                 110         
Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr
        115                 120                 125             
Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly
    130                 135                 140                 
His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His
145                 150                 155                 160 
Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn
                165                 170                 175     
Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn
            180                 185                 190         
Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn
        195                 200                 205             
Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val
    210                 215                 220                 
Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu
225                 230                 235                 240 
Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro
                245                 250                 255     
Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu
            260                 265                 270         
Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile
        275                 280                 285             
Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn
    290                 295                 300                 
Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala
305                 310                 315                 320 
Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr
                325                 330                 335     
Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val
            340                 345                 350         
Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser
        355                 360                 365             
Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala
    370                 375                 380                 
Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr
385                 390                 395                 400 
Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val
                405                 410                 415     
Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly
            420                 425                 430         
Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg
        435                 440                 445             
Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg
    450                 455                 460                 
Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His
465                 470                 475                 480 
Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn
                485                 490                 495     
Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg
            500                 505                 510         
Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe
        515                 520                 525             
Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser
    530                 535                 540                 
Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr
545                 550                 555                 560 
Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu
                565                 570                 575     
Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser
            580                 585                 590         
Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys
        595                 600                 605             
Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp
    610                 615                 620                 
Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val
625                 630                 635                 640 
Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu
                645                 650                 655     
Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu
            660                 665                 670         
Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln
        675                 680                 685             
Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu
    690                 695                 700                 
Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu
705                 710                 715                 720 
Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu
                725                 730                 735     
Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met
            740                 745                 750         
Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln
        755                 760                 765             
Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg
    770                 775                 780                 
Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu
785                 790                 


<210> 20
<211> 638
<212> PRT
<213> Human

<220> 
<223> PC2

<400> 20
Met Lys Gly Gly Cys Val Ser Gln Trp Lys Ala Ala Ala Gly Phe Leu
 1               5                  10                  15      
Phe Cys Val Met Val Phe Ala Ser Ala Glu Arg Pro Val Phe Thr Asn
            20                  25                  30          
His Phe Leu Val Glu Leu His Lys Gly Gly Glu Asp Lys Ala Arg Gln
        35                  40                  45              
Val Ala Ala Glu His Gly Phe Gly Val Arg Lys Leu Pro Phe Ala Glu
    50                  55                  60                  
Gly Leu Tyr His Phe Tyr His Asn Gly Leu Ala Lys Ala Lys Arg Arg
65                  70                  75                  80  
Arg Ser Leu His His Lys Gln Gln Leu Glu Arg Asp Pro Arg Val Lys
                85                  90                  95      
Met Ala Leu Gln Gln Glu Gly Phe Asp Arg Lys Lys Arg Gly Tyr Arg
            100                 105                 110         
Asp Ile Asn Glu Ile Asp Ile Asn Met Asn Asp Pro Leu Phe Thr Lys
        115                 120                 125             
Gln Trp Tyr Leu Ile Asn Thr Gly Gln Ala Asp Gly Thr Pro Gly Leu
    130                 135                 140                 
Asp Leu Asn Val Ala Glu Ala Trp Glu Leu Gly Tyr Thr Gly Lys Gly
145                 150                 155                 160 
Val Thr Ile Gly Ile Met Asp Asp Gly Ile Asp Tyr Leu His Pro Asp
                165                 170                 175     
Leu Ala Ser Asn Tyr Asn Ala Glu Ala Ser Tyr Asp Phe Ser Ser Asn
            180                 185                 190         
Asp Pro Tyr Pro Tyr Pro Arg Tyr Thr Asp Asp Trp Phe Asn Ser His
        195                 200                 205             
Gly Thr Arg Cys Ala Gly Glu Val Ser Ala Ala Ala Asn Asn Asn Ile
    210                 215                 220                 
Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Ala Gly Ile Arg Met
225                 230                 235                 240 
Leu Asp Gln Pro Phe Met Thr Asp Ile Ile Glu Ala Ser Ser Ile Ser
                245                 250                 255     
His Met Pro Gln Leu Ile Asp Ile Tyr Ser Ala Ser Trp Gly Pro Thr
            260                 265                 270         
Asp Asn Gly Lys Thr Val Asp Gly Pro Arg Glu Leu Thr Leu Gln Ala
        275                 280                 285             
Met Ala Asp Gly Val Asn Lys Gly Arg Gly Gly Lys Gly Ser Ile Tyr
    290                 295                 300                 
Val Trp Ala Ser Gly Asp Gly Gly Ser Tyr Asp Asp Cys Asn Cys Asp
305                 310                 315                 320 
Gly Tyr Ala Ser Ser Met Trp Thr Ile Ser Ile Asn Ser Ala Ile Asn
                325                 330                 335     
Asp Gly Arg Thr Ala Leu Tyr Asp Glu Ser Cys Ser Ser Thr Leu Ala
            340                 345                 350         
Ser Thr Phe Ser Asn Gly Arg Lys Arg Asn Pro Glu Ala Gly Val Ala
        355                 360                 365             
Thr Thr Asp Leu Tyr Gly Asn Cys Thr Leu Arg His Ser Gly Thr Ser
    370                 375                 380                 
Ala Ala Ala Pro Glu Ala Ala Gly Val Phe Ala Leu Ala Leu Glu Ala
385                 390                 395                 400 
Asn Leu Gly Leu Thr Trp Arg Asp Met Gln His Leu Thr Val Leu Thr
                405                 410                 415     
Ser Lys Arg Asn Gln Leu His Asp Glu Val His Gln Trp Arg Arg Asn
            420                 425                 430         
Gly Val Gly Leu Glu Phe Asn His Leu Phe Gly Tyr Gly Val Leu Asp
        435                 440                 445             
Ala Gly Ala Met Val Lys Met Ala Lys Asp Trp Lys Thr Val Pro Glu
    450                 455                 460                 
Arg Phe His Cys Val Gly Gly Ser Val Gln Asp Pro Glu Lys Ile Pro
465                 470                 475                 480 
Ser Thr Gly Lys Leu Val Leu Thr Leu Thr Thr Asp Ala Cys Glu Gly
                485                 490                 495     
Lys Glu Asn Phe Val Arg Tyr Leu Glu His Val Gln Ala Val Ile Thr
            500                 505                 510         
Val Asn Ala Thr Arg Arg Gly Asp Leu Asn Ile Asn Met Thr Ser Pro
        515                 520                 525             
Met Gly Thr Lys Ser Ile Leu Leu Ser Arg Arg Pro Arg Asp Asp Asp
    530                 535                 540                 
Ser Lys Val Gly Phe Asp Lys Trp Pro Phe Met Thr Thr His Thr Trp
545                 550                 555                 560 
Gly Glu Asp Ala Arg Gly Thr Trp Thr Leu Glu Leu Gly Phe Val Gly
                565                 570                 575     
Ser Ala Pro Gln Lys Gly Val Leu Lys Glu Trp Thr Leu Met Leu His
            580                 585                 590         
Gly Thr Gln Ser Ala Pro Tyr Ile Asp Gln Val Val Arg Asp Tyr Gln
        595                 600                 605             
Ser Lys Leu Ala Met Ser Lys Lys Glu Glu Leu Glu Glu Glu Leu Asp
    610                 615                 620                 
Glu Ala Val Glu Arg Ser Leu Lys Ser Ile Leu Asn Lys Asn
625                 630                 635             


<210> 21
<211> 753
<212> PRT
<213> Human

<220> 
<223> PC1/3

<400> 21
Met Glu Arg Arg Ala Trp Ser Leu Gln Cys Thr Ala Phe Val Leu Phe
 1               5                  10                  15      
Cys Ala Trp Cys Ala Leu Asn Ser Ala Lys Ala Lys Arg Gln Phe Val
            20                  25                  30          
Asn Glu Trp Ala Ala Glu Ile Pro Gly Gly Pro Glu Ala Ala Ser Ala
        35                  40                  45              
Ile Ala Glu Glu Leu Gly Tyr Asp Leu Leu Gly Gln Ile Gly Ser Leu
    50                  55                  60                  
Glu Asn His Tyr Leu Phe Lys His Lys Asn His Pro Arg Arg Ser Arg
65                  70                  75                  80  
Arg Ser Ala Phe His Ile Thr Lys Arg Leu Ser Asp Asp Asp Arg Val
                85                  90                  95      
Ile Trp Ala Glu Gln Gln Tyr Glu Lys Glu Arg Ser Lys Arg Ser Ala
            100                 105                 110         
Leu Arg Asp Ser Ala Leu Asn Leu Phe Asn Asp Pro Met Trp Asn Gln
        115                 120                 125             
Gln Trp Tyr Leu Gln Asp Thr Arg Met Thr Ala Ala Leu Pro Lys Leu
    130                 135                 140                 
Asp Leu His Val Ile Pro Val Trp Gln Lys Gly Ile Thr Gly Lys Gly
145                 150                 155                 160 
Val Val Ile Thr Val Leu Asp Asp Gly Leu Glu Trp Asn His Thr Asp
                165                 170                 175     
Ile Tyr Ala Asn Tyr Asp Pro Glu Ala Ser Tyr Asp Phe Asn Asp Asn
            180                 185                 190         
Asp His Asp Pro Phe Pro Arg Tyr Asp Pro Thr Asn Glu Asn Lys His
        195                 200                 205             
Gly Thr Arg Cys Ala Gly Glu Ile Ala Met Gln Ala Asn Asn His Lys
    210                 215                 220                 
Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Gly Gly Ile Arg Met
225                 230                 235                 240 
Leu Asp Gly Ile Val Thr Asp Ala Ile Glu Ala Ser Ser Ile Gly Phe
                245                 250                 255     
Asn Pro Gly His Val Asp Ile Tyr Ser Ala Ser Trp Gly Pro Asn Asp
            260                 265                 270         
Asp Gly Lys Thr Val Glu Gly Pro Gly Arg Leu Ala Gln Lys Ala Phe
        275                 280                 285             
Glu Tyr Gly Val Lys Gln Gly Arg Gln Gly Lys Gly Ser Ile Phe Val
    290                 295                 300                 
Trp Ala Ser Gly Asn Gly Gly Arg Gln Gly Asp Asn Cys Asp Cys Asp
305                 310                 315                 320 
Gly Tyr Thr Asp Ser Ile Tyr Thr Ile Ser Ile Ser Ser Ala Ser Gln
                325                 330                 335     
Gln Gly Leu Ser Pro Trp Tyr Ala Glu Lys Cys Ser Ser Thr Leu Ala
            340                 345                 350         
Thr Ser Tyr Ser Ser Gly Asp Tyr Thr Asp Gln Arg Ile Thr Ser Ala
        355                 360                 365             
Asp Leu His Asn Asp Cys Thr Glu Thr His Thr Gly Thr Ser Ala Ser
    370                 375                 380                 
Ala Pro Leu Ala Ala Gly Ile Phe Ala Leu Ala Leu Glu Ala Asn Pro
385                 390                 395                 400 
Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Trp Thr Ser Glu
                405                 410                 415     
Tyr Asp Pro Leu Ala Asn Asn Pro Gly Trp Lys Lys Asn Gly Ala Gly
            420                 425                 430         
Leu Met Val Asn Ser Arg Phe Gly Phe Gly Leu Leu Asn Ala Lys Ala
        435                 440                 445             
Leu Val Asp Leu Ala Asp Pro Arg Thr Trp Arg Ser Val Pro Glu Lys
    450                 455                 460                 
Lys Glu Cys Val Val Lys Asp Asn Asp Phe Glu Pro Arg Ala Leu Lys
465                 470                 475                 480 
Ala Asn Gly Glu Val Ile Ile Glu Ile Pro Thr Arg Ala Cys Glu Gly
                485                 490                 495     
Gln Glu Asn Ala Ile Lys Ser Leu Glu His Val Gln Phe Glu Ala Thr
            500                 505                 510         
Ile Glu Tyr Ser Arg Arg Gly Asp Leu His Val Thr Leu Thr Ser Ala
        515                 520                 525             
Ala Gly Thr Ser Thr Val Leu Leu Ala Glu Arg Glu Arg Asp Thr Ser
    530                 535                 540                 
Pro Asn Gly Phe Lys Asn Trp Asp Phe Met Ser Val His Thr Trp Gly
545                 550                 555                 560 
Glu Asn Pro Ile Gly Thr Trp Thr Leu Arg Ile Thr Asp Met Ser Gly
                565                 570                 575     
Arg Ile Gln Asn Glu Gly Arg Ile Val Asn Trp Lys Leu Ile Leu His
            580                 585                 590         
Gly Thr Ser Ser Gln Pro Glu His Met Lys Gln Pro Arg Val Tyr Thr
        595                 600                 605             
Ser Tyr Asn Thr Val Gln Asn Asp Arg Arg Gly Val Glu Lys Met Val
    610                 615                 620                 
Asp Pro Gly Glu Glu Gln Pro Thr Gln Glu Asn Pro Lys Glu Asn Thr
625                 630                 635                 640 
Leu Val Ser Lys Ser Pro Ser Ser Ser Ser Val Gly Gly Arg Arg Asp
                645                 650                 655     
Glu Leu Glu Glu Gly Ala Pro Ser Gln Ala Met Leu Arg Leu Leu Gln
            660                 665                 670         
Ser Ala Phe Ser Lys Asn Ser Pro Pro Lys Gln Ser Pro Lys Lys Ser
        675                 680                 685             
Pro Ser Ala Lys Leu Asn Ile Pro Tyr Glu Asn Phe Tyr Glu Ala Leu
    690                 695                 700                 
Glu Lys Leu Asn Lys Pro Ser Gln Leu Lys Asp Ser Glu Asp Ser Leu
705                 710                 715                 720 
Tyr Asn Asp Tyr Val Asp Val Phe Tyr Asn Thr Lys Pro Tyr Lys His
                725                 730                 735     
Arg Asp Asp Arg Leu Leu Gln Ala Leu Val Asp Ile Leu Asn Glu Glu
            740                 745                 750         
Asn
    


<210> 22
<211> 755
<212> PRT
<213> Human

<220> 
<223> PC4

<400> 22
Met Arg Pro Ala Pro Ile Ala Leu Trp Leu Arg Leu Val Leu Ala Leu
 1               5                  10                  15      
Ala Leu Val Arg Pro Arg Ala Val Gly Trp Ala Pro Val Arg Ala Pro
            20                  25                  30          
Ile Tyr Val Ser Ser Trp Ala Val Gln Val Ser Gln Gly Asn Arg Glu
        35                  40                  45              
Val Glu Arg Leu Ala Arg Lys Phe Gly Phe Val Asn Leu Gly Pro Ile
    50                  55                  60                  
Phe Pro Asp Gly Gln Tyr Phe His Leu Arg His Arg Gly Val Val Gln
65                  70                  75                  80  
Gln Ser Leu Thr Pro His Trp Gly His Arg Leu His Leu Lys Lys Asn
                85                  90                  95      
Pro Lys Val Gln Trp Phe Gln Gln Gln Thr Leu Gln Arg Arg Val Lys
            100                 105                 110         
Arg Ser Val Val Val Pro Thr Asp Pro Trp Phe Ser Lys Gln Trp Tyr
        115                 120                 125             
Met Asn Ser Glu Ala Gln Pro Asp Leu Ser Ile Leu Gln Ala Trp Ser
    130                 135                 140                 
Gln Gly Leu Ser Gly Gln Gly Ile Val Val Ser Val Leu Asp Asp Gly
145                 150                 155                 160 
Ile Glu Lys Asp His Pro Asp Leu Trp Ala Asn Tyr Asp Pro Leu Ala
                165                 170                 175     
Ser Tyr Asp Phe Asn Asp Tyr Asp Pro Asp Pro Gln Pro Arg Tyr Thr
            180                 185                 190         
Pro Ser Lys Glu Asn Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala
        195                 200                 205             
Ala Met Ala Asn Asn Gly Phe Cys Gly Val Gly Val Ala Phe Asn Ala
    210                 215                 220                 
Arg Ile Gly Gly Val Arg Met Leu Asp Gly Thr Ile Thr Asp Val Ile
225                 230                 235                 240 
Glu Ala Gln Ser Leu Ser Leu Gln Pro Gln His Ile His Ile Tyr Ser
                245                 250                 255     
Ala Ser Trp Gly Pro Glu Asp Asp Gly Arg Thr Val Asp Gly Pro Gly
            260                 265                 270         
Ile Leu Thr Arg Glu Ala Phe Arg Arg Gly Val Thr Lys Gly Arg Gly
        275                 280                 285             
Gly Leu Gly Thr Leu Phe Ile Trp Ala Ser Gly Asn Gly Gly Leu His
    290                 295                 300                 
Tyr Asp Asn Cys Asn Cys Asp Gly Tyr Thr Asn Ser Ile His Thr Leu
305                 310                 315                 320 
Ser Val Gly Ser Thr Thr Gln Gln Gly Arg Val Pro Trp Tyr Ser Glu
                325                 330                 335     
Ala Cys Ala Ser Thr Leu Thr Thr Thr Tyr Ser Ser Gly Val Ala Thr
            340                 345                 350         
Asp Pro Gln Ile Val Thr Thr Asp Leu His His Gly Cys Thr Asp Gln
        355                 360                 365             
His Thr Gly Thr Ser Ala Ser Ala Pro Leu Ala Ala Gly Met Ile Ala
    370                 375                 380                 
Leu Ala Leu Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Met Gln His
385                 390                 395                 400 
Leu Val Val Arg Ala Ser Lys Pro Ala His Leu Gln Ala Glu Asp Trp
                405                 410                 415     
Arg Thr Asn Gly Val Gly Arg Gln Val Ser His His Tyr Gly Tyr Gly
            420                 425                 430         
Leu Leu Asp Ala Gly Leu Leu Val Asp Thr Ala Arg Thr Trp Leu Pro
        435                 440                 445             
Thr Gln Pro Gln Arg Lys Cys Ala Val Arg Val Gln Ser Arg Pro Thr
    450                 455                 460                 
Pro Ile Leu Pro Leu Ile Tyr Ile Arg Glu Asn Val Ser Ala Cys Ala
465                 470                 475                 480 
Gly Leu His Asn Ser Ile Arg Ser Leu Glu His Val Gln Ala Gln Leu
                485                 490                 495     
Thr Leu Ser Tyr Ser Arg Arg Gly Asp Leu Glu Ile Ser Leu Thr Ser
            500                 505                 510         
Pro Met Gly Thr Arg Ser Thr Leu Val Ala Ile Arg Pro Leu Asp Val
        515                 520                 525             
Ser Thr Glu Gly Tyr Asn Asn Trp Val Phe Met Ser Thr His Phe Trp
    530                 535                 540                 
Asp Glu Asn Pro Gln Gly Val Trp Thr Leu Gly Leu Glu Asn Lys Gly
545                 550                 555                 560 
Tyr Tyr Phe Asn Thr Gly Thr Leu Tyr Arg Tyr Thr Leu Leu Leu Tyr
                565                 570                 575     
Gly Thr Ala Glu Asp Met Thr Ala Arg Pro Thr Gly Pro Gln Val Thr
            580                 585                 590         
Ser Ser Ala Cys Val Gln Arg Asp Thr Glu Gly Leu Cys Gln Ala Cys
        595                 600                 605             
Asp Gly Pro Ala Tyr Ile Leu Gly Gln Leu Cys Leu Ala Tyr Cys Pro
    610                 615                 620                 
Pro Arg Phe Phe Asn His Thr Arg Leu Val Thr Ala Gly Pro Gly His
625                 630                 635                 640 
Thr Ala Ala Pro Ala Leu Arg Val Cys Ser Ser Cys His Ala Ser Cys
                645                 650                 655     
Tyr Thr Cys Arg Gly Gly Ser Pro Arg Asp Cys Thr Ser Cys Pro Pro
            660                 665                 670         
Ser Ser Thr Leu Asp Gln Gln Gln Gly Ser Cys Met Gly Pro Thr Thr
        675                 680                 685             
Pro Asp Ser Arg Pro Arg Leu Arg Ala Ala Ala Cys Pro His His Arg
    690                 695                 700                 
Cys Pro Ala Ser Ala Met Val Leu Ser Leu Leu Ala Val Thr Leu Gly
705                 710                 715                 720 
Gly Pro Val Leu Cys Gly Met Ser Met Asp Leu Pro Leu Tyr Ala Trp
                725                 730                 735     
Leu Ser Arg Ala Arg Ala Thr Pro Thr Lys Pro Gln Val Trp Leu Pro
            740                 745                 750         
Ala Gly Thr
        755 


<210> 23
<211> 969
<212> PRT
<213> Human

<220> 
<223> PACE4

<400> 23
Met Pro Pro Arg Ala Pro Pro Ala Pro Gly Pro Arg Pro Pro Pro Arg
 1               5                  10                  15      
Ala Ala Ala Ala Thr Asp Thr Ala Ala Gly Ala Gly Gly Ala Gly Gly
            20                  25                  30          
Ala Gly Gly Ala Gly Gly Pro Gly Phe Arg Pro Leu Ala Pro Arg Pro
        35                  40                  45              
Trp Arg Trp Leu Leu Leu Leu Ala Leu Pro Ala Ala Cys Ser Ala Pro
    50                  55                  60                  
Pro Pro Arg Pro Val Tyr Thr Asn His Trp Ala Val Gln Val Leu Gly
65                  70                  75                  80  
Gly Pro Ala Glu Ala Asp Arg Val Ala Ala Ala His Gly Tyr Leu Asn
                85                  90                  95      
Leu Gly Gln Ile Gly Asn Leu Glu Asp Tyr Tyr His Phe Tyr His Ser
            100                 105                 110         
Lys Thr Phe Lys Arg Ser Thr Leu Ser Ser Arg Gly Pro His Thr Phe
        115                 120                 125             
Leu Arg Met Asp Pro Gln Val Lys Trp Leu Gln Gln Gln Glu Val Lys
    130                 135                 140                 
Arg Arg Val Lys Arg Gln Val Arg Ser Asp Pro Gln Ala Leu Tyr Phe
145                 150                 155                 160 
Asn Asp Pro Ile Trp Ser Asn Met Trp Tyr Leu His Cys Gly Asp Lys
                165                 170                 175     
Asn Ser Arg Cys Arg Ser Glu Met Asn Val Gln Ala Ala Trp Lys Arg
            180                 185                 190         
Gly Tyr Thr Gly Lys Asn Val Val Val Thr Ile Leu Asp Asp Gly Ile
        195                 200                 205             
Glu Arg Asn His Pro Asp Leu Ala Pro Asn Tyr Asp Ser Tyr Ala Ser
    210                 215                 220                 
Tyr Asp Val Asn Gly Asn Asp Tyr Asp Pro Ser Pro Arg Tyr Asp Ala
225                 230                 235                 240 
Ser Asn Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala
                245                 250                 255     
Ser Ala Asn Asn Ser Tyr Cys Ile Val Gly Ile Ala Tyr Asn Ala Lys
            260                 265                 270         
Ile Gly Gly Ile Arg Met Leu Asp Gly Asp Val Thr Asp Val Val Glu
        275                 280                 285             
Ala Lys Ser Leu Gly Ile Arg Pro Asn Tyr Ile Asp Ile Tyr Ser Ala
    290                 295                 300                 
Ser Trp Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Gly Arg
305                 310                 315                 320 
Leu Ala Lys Gln Ala Phe Glu Tyr Gly Ile Lys Lys Gly Arg Gln Gly
                325                 330                 335     
Leu Gly Ser Ile Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu Gly
            340                 345                 350         
Asp Tyr Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser
        355                 360                 365             
Val Ser Ser Ala Thr Glu Asn Gly Tyr Lys Pro Trp Tyr Leu Glu Glu
    370                 375                 380                 
Cys Ala Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Ala Phe Tyr Glu
385                 390                 395                 400 
Arg Lys Ile Val Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Gly His
                405                 410                 415     
Thr Gly Thr Ser Val Ser Ala Pro Met Val Ala Gly Ile Ile Ala Leu
            420                 425                 430         
Ala Leu Glu Ala Asn Ser Gln Leu Thr Trp Arg Asp Val Gln His Leu
        435                 440                 445             
Leu Val Lys Thr Ser Arg Pro Ala His Leu Lys Ala Ser Asp Trp Lys
    450                 455                 460                 
Val Asn Gly Ala Gly His Lys Val Ser His Phe Tyr Gly Phe Gly Leu
465                 470                 475                 480 
Val Asp Ala Glu Ala Leu Val Val Glu Ala Lys Lys Trp Thr Ala Val
                485                 490                 495     
Pro Ser Gln His Met Cys Val Ala Ala Ser Asp Lys Arg Pro Arg Ser
            500                 505                 510         
Ile Pro Leu Val Gln Val Leu Arg Thr Thr Ala Leu Thr Ser Ala Cys
        515                 520                 525             
Ala Glu His Ser Asp Gln Arg Val Val Tyr Leu Glu His Val Val Val
    530                 535                 540                 
Arg Thr Ser Ile Ser His Pro Arg Arg Gly Asp Leu Gln Ile Tyr Leu
545                 550                 555                 560 
Val Ser Pro Ser Gly Thr Lys Ser Gln Leu Leu Ala Lys Arg Leu Leu
                565                 570                 575     
Asp Leu Ser Asn Glu Gly Phe Thr Asn Trp Glu Phe Met Thr Val His
            580                 585                 590         
Cys Trp Gly Glu Lys Ala Glu Gly Gln Trp Thr Leu Glu Ile Gln Asp
        595                 600                 605             
Leu Pro Ser Gln Val Arg Asn Pro Glu Lys Gln Gly Lys Leu Lys Glu
    610                 615                 620                 
Trp Ser Leu Ile Leu Tyr Gly Thr Ala Glu His Pro Tyr His Thr Phe
625                 630                 635                 640 
Ser Ala His Gln Ser Arg Ser Arg Met Leu Glu Leu Ser Ala Pro Glu
                645                 650                 655     
Leu Glu Pro Pro Lys Ala Ala Leu Ser Pro Ser Gln Val Glu Val Pro
            660                 665                 670         
Glu Asp Glu Glu Asp Tyr Thr Ala Gln Ser Thr Pro Gly Ser Ala Asn
        675                 680                 685             
Ile Leu Gln Thr Ser Val Cys His Pro Glu Cys Gly Asp Lys Gly Cys
    690                 695                 700                 
Asp Gly Pro Asn Ala Asp Gln Cys Leu Asn Cys Val His Phe Ser Leu
705                 710                 715                 720 
Gly Ser Val Lys Thr Ser Arg Lys Cys Val Ser Val Cys Pro Leu Gly
                725                 730                 735     
Tyr Phe Gly Asp Thr Ala Ala Arg Arg Cys Arg Arg Cys His Lys Gly
            740                 745                 750         
Cys Glu Thr Cys Ser Ser Arg Ala Ala Thr Gln Cys Leu Ser Cys Arg
        755                 760                 765             
Arg Gly Phe Tyr His His Gln Glu Met Asn Thr Cys Val Thr Leu Cys
    770                 775                 780                 
Pro Ala Gly Phe Tyr Ala Asp Glu Ser Gln Lys Asn Cys Leu Lys Cys
785                 790                 795                 800 
His Pro Ser Cys Lys Lys Cys Val Asp Glu Pro Glu Lys Cys Thr Val
                805                 810                 815     
Cys Lys Glu Gly Phe Ser Leu Ala Arg Gly Ser Cys Ile Pro Asp Cys
            820                 825                 830         
Glu Pro Gly Thr Tyr Phe Asp Ser Glu Leu Ile Arg Cys Gly Glu Cys
        835                 840                 845             
His His Thr Cys Gly Thr Cys Val Gly Pro Gly Arg Glu Glu Cys Ile
    850                 855                 860                 
His Cys Ala Lys Asn Phe His Phe His Asp Trp Lys Cys Val Pro Ala
865                 870                 875                 880 
Cys Gly Glu Gly Phe Tyr Pro Glu Glu Met Pro Gly Leu Pro His Lys
                885                 890                 895     
Val Cys Arg Arg Cys Asp Glu Asn Cys Leu Ser Cys Ala Gly Ser Ser
            900                 905                 910         
Arg Asn Cys Ser Arg Cys Lys Thr Gly Phe Thr Gln Leu Gly Thr Ser
        915                 920                 925             
Cys Ile Thr Asn His Thr Cys Ser Asn Ala Asp Glu Thr Phe Cys Glu
    930                 935                 940                 
Met Val Lys Ser Asn Arg Leu Cys Glu Arg Lys Leu Phe Ile Gln Phe
945                 950                 955                 960 
Cys Cys Arg Thr Cys Leu Leu Ala Gly
                965                 


<210> 24
<211> 4403
<212> DNA
<213> Human

<220> 
<223> PACE4

<400> 24
cgggaacgcg ccgcggccgc ctcctcctcc ccggctcccg cccgcggcgg tgttggcggc 60
ggcggtggcg gcggcggcgg cgcttccccg gcgcggagcg gctttaaaag gcggcactcc 120
accccccggc gcactcgcag ctcgggcgcc gcgcgagcct gtcgccgcta tgcctccgcg 180
cgcgccgcct gcgcccgggc cccggccgcc gccccgggcc gccgccgcca ccgacaccgc 240
cgcgggcgcg gggggcgcgg ggggcgcggg gggcgccggc gggcccgggt tccggccgct 300
cgcgccgcgt ccctggcgct ggctgctgct gctggcgctg cctgccgcct gctccgcgcc 360
cccgccgcgc cccgtctaca ccaaccactg ggcggtgcaa gtgctgggcg gcccggccga 420
ggcggaccgc gtggcggcgg cgcacggcta cctcaacttg ggccagattg gaaacctgga 480
agattactac catttttatc acagcaaaac ctttaaaaga tcaaccttga gtagcagagg 540
ccctcacacc ttcctcagaa tggaccccca ggtgaaatgg ctccagcaac aggaagtgaa 600
acgaagggtg aagagacagg tgcgaagtga cccgcaggcc ctttacttca acgaccccat 660
ttggtccaac atgtggtacc tgcattgtgg cgacaagaac agtcgctgcc ggtcggaaat 720
gaatgtccag gcagcgtgga agaggggcta cacaggaaaa aacgtggtgg tcaccatcct 780
tgatgatggc atagagagaa atcaccctga cctggcccca aattatgatt cctacgccag 840
ctacgacgtg aacggcaatg attatgaccc atctccacga tatgatgcca gcaatgaaaa 900
taaacacggc actcgttgtg cgggagaagt tgctgcttca gcaaacaatt cctactgcat 960
cgtgggcata gcgtacaatg ccaaaatagg aggcatccgc atgctggacg gcgatgtcac 1020
agatgtggtc gaggcaaagt cgctgggcat cagacccaac tacatcgaca tttacagtgc 1080
cagctggggg ccggacgacg acggcaagac ggtggacggg cccggccgac tggctaagca 1140
ggctttcgag tatggcatta aaaagggccg gcagggcctg ggctccattt tcgtctgggc 1200
atctgggaat ggcgggagag agggggacta ctgctcgtgc gatggctaca ccaacagcat 1260
ctacaccatc tccgtcagca gcgccaccga gaatggctac aagccctggt acctggaaga 1320
gtgtgcctcc accctggcca ccacctacag cagtggggcc ttttatgagc gaaaaatcgt 1380
caccacggat ctgcgtcagc gctgtaccga tggccacact gggacctcag tctctgcccc 1440
catggtggcg ggcatcatcg ccttggctct agaagcaaac agccagttaa cctggaggga 1500
cgtccagcac ctgctagtga agacatcccg gccggcccac ctgaaagcga gcgactggaa 1560
agtaaacggc gcgggtcata aagttagcca tttctatgga tttggtttgg tggacgcaga 1620
agctctcgtt gtggaggcaa agaagtggac agcagtgcca tcgcagcaca tgtgtgtggc 1680
cgcctcggac aagagaccca ggagcatccc cttagtgcag gtgctgcgga ctacggccct 1740
gaccagcgcc tgcgcggagc actcggacca gcgggtggtc tacttggagc acgtggtggt 1800
tcgcacctcc atctcacacc cacgccgagg agacctccag atctacctgg tttctccctc 1860
gggaaccaag tctcaacttt tggcaaagag gttgctggat ctttccaatg aagggtttac 1920
aaactgggaa ttcatgactg tccactgctg gggagaaaag gctgaagggc agtggacctt 1980
ggaaatccaa gatctgccat cccaggtccg caacccggag aagcaaggga agttgaaaga 2040
atggagcctc atactgtatg gcacagcaga gcacccgtac cacaccttca gtgcccatca 2100
gtcccgctcg cggatgctgg agctctcagc cccagagctg gagccaccca aggctgccct 2160
gtcaccctcc caggtggaag ttcctgaaga tgaggaagat tacacagctc aatccacccc 2220
aggctctgct aatattttac agaccagtgt gtgccatccg gagtgtggtg acaaaggctg 2280
tgatggcccc aatgcagacc agtgcttgaa ctgcgtccac ttcagcctgg ggagtgtcaa 2340
gaccagcagg aagtgcgtga gtgtgtgccc cttgggctac tttggggaca cagcagcaag 2400
acgctgtcgc cggtgccaca aggggtgtga gacctgctcc agcagagctg cgacgcagtg 2460
cctgtcttgc cgccgcgggt tctatcacca ccaggagatg aacacctgtg tgaccctctg 2520
tcctgcagga ttttatgctg atgaaagtca gaaaaattgc cttaaatgcc acccaagctg 2580
taaaaagtgc gtggatgaac ctgagaaatg tactgtctgt aaagaaggat tcagccttgc 2640
acggggcagc tgcattcctg actgtgagcc aggcacctac tttgactcag agctgatcag 2700
atgtggggaa tgccatcaca cctgcggaac ctgcgtgggg ccaggcagag aagagtgcat 2760
tcactgtgcg aaaaacttcc acttccacga ctggaagtgt gtgccagcct gtggtgaggg 2820
cttctaccca gaagagatgc cgggcttgcc ccacaaagtg tgtcgaaggt gtgacgagaa 2880
ctgcttgagc tgtgcaggct ccagcaggaa ctgtagcagg tgtaagacgg gcttcacaca 2940
gctggggacc tcctgcatca ccaaccacac gtgcagcaac gctgacgaga cattctgcga 3000
gatggtgaag tccaaccggc tgtgcgaacg gaagctcttc attcagttct gctgccgcac 3060
gtgcctcctg gccgggtaag ggtgcctagc tgcccacaga gggcaggcac tcccatccat 3120
ccatccgtcc accttcctcc agactgtcgg ccagagtctg tttcaggagc ggcgccctgc 3180
acctgacagc tttatctccc caggagcagc atctctgagc acccaagcca ggtgggtggt 3240
ggctcttaag gaggtgttcc taaaatggtg atatcctctc aaatgctgct tgttggctcc 3300
agtcttccga caaactaaca ggaacaaaat gaattctggg aatccacagc tctggctttg 3360
gagcagcttc tgggaccata agtttactga atcttcaaga ccaaagcaga aaagaaaggc 3420
gcttggcatc acacatcact cttctccccg tgcttttctg cggctgtgta gtaaatctcc 3480
ccggcccagc tggcgaaccc tgggccatcc tcacatgtga caaagggcca gcagtctacc 3540
tgctcgttgc ctgccactga gcagtctggg gacggtttgg tcagactata aataagatag 3600
gtttgagggc ataaaatgta tgaccactgg ggccggagta tctatttcta catagtcagc 3660
tacttctgaa actgcagcag tggcttagaa agtccaattc caaagccaga ccagaagatt 3720
ctatcccccg cagcgctctc ctttgagcaa gccgagctct ccttgttacc gtgttctgtc 3780
tgtgtcttca ggagtctcat ggcctgaacg accacctcga cctgatgcag agccttctga 3840
ggagaggcaa caggaggcat tctgtggcca gccaaaaggt accccgatgg ccaagcaatt 3900
cctctgaaca aaatgtaaag ccagccatgc attgttaatc atccatcact tcccatttta 3960
tggaattgct tttaaaatac atttggcctc tgcccttcag aagactcgtt tttaaggtgg 4020
aaactcctgt gtctgtgtat attacaagcc tacatgacac agttggattt attctgccaa 4080
acctgtgtag gcattttata agctacatgt tctaattttt accgatgtta attattttga 4140
caaatatttc atatattttc attgaaatgc acagatctgc ttgatcaatt cccttgaata 4200
gggaagtaac atttgcctta aattttttcg acctcgtctt tctccatatt gtcctgctcc 4260
cctgtttgac gacagtgcat ttgccttgtc acctgtgagc tggagagaac ccagatgttg 4320
tttattgaat ctacaactct gaaagagaaa tcaatgaagc aagtacaatg ttaaccctaa 4380
attaataaaa gagttaacat ccc                                         4403

<210> 25
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 25
ccgggagaga agtctcctct gcattctcga gaatgcagag gagacttctc tctttttg   58

<210> 26
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 26
ccggcctaga gaacaagggc tactactcga gtagtagccc ttgttctcta ggtttttg   58

<210> 27
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 27
ccggaggcta caacaactgg gtcttctcga gaagacccag ttgttgtagc cttttttg   58

<210> 28
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 28
ccggcctccc actatacgcc tggctctcga gagccaggcg tatagtggga ggtttttg   58

<210> 29
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Sequence

<400> 29
ccggcccttg gacgtcagca ctgaactcga gttcagtgct gacgtccaag ggtttttg   58
