
                                SEQUENCE LISTING

<110> Universit Laval
      Instituto Mexicano del Seguro Social
      LECLERC, Denis
      LOPEZ-MACIAS, Constantino III Roberto

<120> COMPOSITIONS COMPRISING SALMONELLA
  PORINS AND USES THEREOF AS ADJUVANTS AND VACCINES
  

<130> 1750-107PCT

<140> n/a                 
<141> 2009-06-17  

<150> 61/073,118          
<151> 2008-06-17  

<160> 23

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 377
<212> PRT
<213> Salmonella enterica subsp. enterica serovar Typhi Ty2

<400> 1
Met Lys Val Lys Val Leu Ser Leu Leu Val Pro Ala Leu Leu Val Ala
 1               5                  10                  15      
Gly Ala Ala Asn Ala Ala Glu Ile Tyr Asn Lys Asp Gly Asn Lys Leu
            20                  25                  30          
Asp Leu Phe Gly Lys Val Asp Gly Leu His Tyr Phe Ser Asp Asp Gly
        35                  40                  45              
Ser Asp Gly Asp Gln Thr Tyr Met Arg Ile Gly Phe Lys Gly Glu Thr
    50                  55                  60                  
Gln Val Asn Asp Gln Leu Thr Gly Tyr Gly Gln Trp Glu Tyr Gln Ile
65                  70                  75                  80  
Gln Gly Asn Gln Thr Glu Gly Ser Asn Asp Ser Trp Thr Arg Val Ala
                85                  90                  95      
Phe Ala Gly Leu Lys Phe Ala Asp Ala Gly Ser Phe Asp Tyr Gly Arg
            100                 105                 110         
Asn Tyr Gly Val Thr Tyr Asp Val Thr Ser Trp Thr Asp Val Leu Pro
        115                 120                 125             
Glu Phe Gly Gly Asp Thr Tyr Gly Ala Asp Asn Phe Met Gln Gln Arg
    130                 135                 140                 
Gly Asn Gly Tyr Ala Thr Tyr Arg Asn Thr Asp Phe Phe Gly Leu Val
145                 150                 155                 160 
Asp Gly Leu Asp Phe Ala Leu Gln Tyr Gln Gly Lys Asn Gly Ser Val
                165                 170                 175     
Ser Gly Glu Asn Thr Asn Gly Arg Ser Leu Leu Asn Gln Asn Gly Asp
            180                 185                 190         
Gly Tyr Gly Gly Ser Leu Thr Tyr Ala Ile Gly Glu Gly Phe Ser Val
        195                 200                 205             
Gly Gly Ala Ile Thr Thr Ser Lys Arg Thr Ala Asp Gln Asn Asn Thr
    210                 215                 220                 
Ala Asn Ala Arg Leu Tyr Gly Asn Gly Asp Arg Ala Thr Val Tyr Thr
225                 230                 235                 240 
Gly Gly Leu Lys Tyr Asp Ala Asn Asn Ile Tyr Leu Ala Ala Gln Tyr
                245                 250                 255     
Ser Gln Thr Tyr Asn Ala Thr Arg Phe Gly Thr Ser Asn Gly Ser Asn
            260                 265                 270         
Pro Ser Thr Ser Tyr Gly Phe Ala Asn Lys Ala Gln Asn Phe Glu Val
        275                 280                 285             
Val Ala Gln Tyr Gln Phe Asp Phe Gly Leu Arg Pro Ser Val Ala Tyr
    290                 295                 300                 
Leu Gln Ser Lys Gly Lys Asp Ile Ser Asn Gly Tyr Gly Ala Ser Tyr
305                 310                 315                 320 
Gly Asp Gln Asp Ile Val Lys Tyr Val Asp Val Gly Ala Thr Tyr Tyr
                325                 330                 335     
Phe Asn Lys Asn Met Ser Thr Tyr Val Asp Tyr Lys Ile Asn Leu Leu
            340                 345                 350         
Asp Lys Asn Asp Phe Thr Arg Asp Ala Gly Ile Asn Thr Asp Asp Ile
        355                 360                 365             
Val Ala Leu Gly Leu Val Tyr Gln Phe
    370                 375         


<210> 2
<211> 363
<212> PRT
<213> Salmonella enterica subsp. enterica serovar Typhi CT18

<400> 2
Met Met Lys Arg Lys Ile Leu Ala Ala Val Ile Pro Ala Leu Leu Ala
 1               5                  10                  15      
Ala Ala Thr Ala Asn Ala Ala Glu Ile Tyr Asn Lys Asp Gly Asn Lys
            20                  25                  30          
Leu Asp Leu Tyr Gly Lys Ala Val Gly Arg His Val Trp Thr Thr Thr
        35                  40                  45              
Gly Asp Ser Lys Asn Ala Asp Gln Thr Tyr Ala Gln Ile Gly Phe Lys
    50                  55                  60                  
Gly Glu Thr Gln Ile Asn Thr Asp Leu Thr Gly Phe Gly Gln Trp Glu
65                  70                  75                  80  
Tyr Arg Thr Lys Ala Asp Arg Ala Glu Gly Glu Gln Gln Asn Ser Asn
                85                  90                  95      
Leu Val Arg Leu Ala Phe Ala Gly Leu Lys Tyr Ala Glu Val Gly Ser
            100                 105                 110         
Ile Asp Tyr Gly Arg Asn Tyr Gly Ile Val Tyr Asp Val Glu Ser Tyr
        115                 120                 125             
Thr Asp Met Ala Pro Tyr Phe Ser Gly Glu Thr Trp Gly Gly Ala Tyr
    130                 135                 140                 
Thr Asp Asn Tyr Met Thr Ser Arg Ala Gly Gly Leu Leu Thr Tyr Arg
145                 150                 155                 160 
Asn Ser Asp Phe Phe Gly Leu Val Asp Gly Leu Ser Phe Gly Ile Gln
                165                 170                 175     
Tyr Gln Gly Lys Asn Gln Asp Asn His Ser Ile Asn Ser Gln Asn Gly
            180                 185                 190         
Asp Gly Val Gly Tyr Thr Met Ala Tyr Glu Phe Asp Gly Phe Gly Val
        195                 200                 205             
Thr Ala Ala Tyr Ser Asn Ser Lys Arg Thr Asn Asp Gln Gln Asp Arg
    210                 215                 220                 
Asp Gly Asn Gly Asp Arg Ala Glu Ser Trp Ala Val Gly Ala Lys Tyr
225                 230                 235                 240 
Asp Ala Asn Asn Val Tyr Leu Ala Ala Val Tyr Ala Glu Thr Arg Asn
                245                 250                 255     
Met Ser Ile Val Glu Asn Thr Val Thr Asp Thr Val Glu Met Ala Asn
            260                 265                 270         
Lys Thr Gln Asn Leu Glu Val Val Ala Gln Tyr Gln Phe Asp Phe Gly
        275                 280                 285             
Leu Arg Pro Ala Ile Ser Tyr Val Gln Ser Lys Gly Lys Gln Leu Asn
    290                 295                 300                 
Gly Ala Asp Gly Ser Ala Asp Leu Ala Lys Tyr Ile Gln Ala Gly Ala
305                 310                 315                 320 
Thr Tyr Tyr Phe Asn Lys Asn Met Asn Val Trp Val Asp Tyr Arg Phe
                325                 330                 335     
Asn Leu Leu Asp Glu Asn Asp Tyr Ser Ser Ser Tyr Val Gly Thr Asp
            340                 345                 350         
Asp Gln Ala Ala Val Gly Ile Thr Tyr Gln Phe
        355                 360             


<210> 3
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide from Human H1N1 e.g. A/USRR/90/77 and
      A/WSN/33

<400> 3
Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys
 1               5                  10                  15      
Arg Cys Asn Asp Ser Ser Asp
            20              


<210> 4
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide

<400> 4
Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys
 1               5                  10                  15      
Arg Cys Asn Gly Ser Ser Asp
            20              


<210> 5
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide

<400> 5
Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Lys Asn Glu Trp Asp Cys
 1               5                  10                  15      
Arg Cys Asn Asp Ser Ser Asp
            20              


<210> 6
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide from Equine H3N8
      A/equine/Massachussetts/
      213/2003
      

<400> 6
Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Gly Trp Glu Cys
 1               5                  10                  15      
Lys Cys Ser Asp Ser Ser Asp
            20              


<210> 7
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide from H5N1 A/Vietnam/1196/04
      

<400> 7
Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Glu Trp Glu Cys
 1               5                  10                  15      
Arg Cys Ser Asp Ser Ser Asp
            20              


<210> 8
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide from Human H1N1 e.g. A/USRR/90/77 and
      A/WSN/33
      

<400> 8
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly
 1               5                  10                  15      
Cys Arg Cys Asn Asp Ser Ser Asp
            20                  


<210> 9
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide from Avian H5N1 A/Vietnam/1196/04

<400> 9
His Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Glu Trp Glu
 1               5                  10                  15      
Cys Arg Cys Ser Asp Ser Ser Asp
            20                  


<210> 10
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide from H3N8, Horse-Dog
      A/equine/Massachussetts/
      213/2003
      

<400> 10
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Gly Trp Glu
 1               5                  10                  15      
Cys Lys Cys Ser Asp Ser Ser Asp
            20                  


<210> 11
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide from H9N2, A/chicken/Osaka/aq69/2001

<400> 11
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Gly Trp Gly
 1               5                  10                  15      
Cys Arg Cys Ser Asp Ser Ser Asp
            20                  


<210> 12
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e peptide from Mutant H1N1 I/T

<400> 12
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Glu Trp Gly
 1               5                  10                  15      
Cys Arg Cys Ser Asp Ser Ser Asp
            20                  


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> M2e conserved epitope

<400> 13
Glu Val Glu Thr Pro Ile Arg Asn
 1               5              


<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variant of M2e conserved epitope

<400> 14
Glu Val Glu Thr Leu Thr Arg Asn
 1               5              


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variant of M2e conserved epitope

<400> 15
Glu Val Glu Thr Pro Ile Arg Ser
 1               5              


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variant of M2e conserved epitope

<400> 16
Glu Val Glu Thr Pro Thr Arg Asn
 1               5              


<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variant of M2e conserved epitope

<400> 17
Glu Val Glu Thr Pro Thr Lys Asn
 1               5              


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variant of M2e conserved epitope

<400> 18
Glu Val Asp Thr Leu Thr Arg Asn
 1               5              


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variant of M2e conserved epitope

<400> 19
Glu Val Glu Thr Pro Ile Arg Lys
 1               5              


<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variant of M2e conserved epitope

<400> 20
Glu Val Glu Thr Leu Thr Lys Asn
 1               5              


<210> 21
<211> 363
<212> PRT
<213> Salmonella typhi

<400> 21
Met Met Lys Arg Lys Ile Leu Ala Ala Val Ile Pro Ala Leu Leu Ala
 1               5                  10                  15      
Ala Ala Thr Ala Asn Ala Ala Glu Ile Tyr Asn Lys Asp Gly Asn Lys
            20                  25                  30          
Leu Asp Leu Tyr Gly Lys Ala Val Gly Arg His Val Trp Thr Thr Thr
        35                  40                  45              
Gly Asp Ser Lys Asn Ala Asp Gln Thr Tyr Ala Gln Ile Gly Phe Lys
    50                  55                  60                  
Gly Glu Thr Gln Ile Asn Thr Asp Leu Thr Gly Phe Gly Gln Trp Glu
65                  70                  75                  80  
Tyr Arg Thr Lys Ala Asp Arg Ala Glu Gly Glu Gln Gln Asn Ser Asn
                85                  90                  95      
Leu Val Arg Leu Ala Phe Ala Gly Leu Lys Tyr Ala Glu Val Gly Ser
            100                 105                 110         
Ile Asp Tyr Gly Arg Asn Tyr Gly Ile Val Tyr Asp Val Glu Ser Tyr
        115                 120                 125             
Thr Asp Met Ala Pro Tyr Phe Ser Gly Glu Thr Trp Gly Gly Ala Tyr
    130                 135                 140                 
Thr Asp Asn Tyr Met Thr Ser Arg Ala Gly Gly Leu Leu Thr Tyr Arg
145                 150                 155                 160 
Asn Ser Asp Phe Phe Gly Leu Val Asp Gly Leu Ser Phe Gly Ile Gln
                165                 170                 175     
Tyr Gln Gly Lys Asn Gln Asp Asn His Ser Ile Asn Ser Gln Asn Gly
            180                 185                 190         
Asp Gly Val Gly Tyr Thr Met Ala Tyr Glu Phe Asp Gly Phe Gly Val
        195                 200                 205             
Thr Ala Ala Tyr Ser Asn Ser Lys Arg Thr Asn Asp Gln Gln Asp Arg
    210                 215                 220                 
Asp Gly Asn Gly Asp Arg Ala Glu Ser Trp Ala Val Gly Ala Lys Tyr
225                 230                 235                 240 
Asp Ala Asn Asn Val Tyr Leu Ala Ala Val Tyr Ala Glu Thr Arg Asn
                245                 250                 255     
Met Ser Ile Val Glu Asn Thr Val Thr Asp Thr Val Glu Met Ala Asn
            260                 265                 270         
Lys Thr Gln Asn Leu Glu Val Val Ala Gln Tyr Gln Phe Asp Phe Gly
        275                 280                 285             
Leu Arg Pro Ala Ile Ser Tyr Val Gln Ser Lys Gly Lys Gln Leu Asn
    290                 295                 300                 
Gly Ala Gly Gly Ser Ala Asp Leu Ala Lys Tyr Ile Gln Ala Gly Ala
305                 310                 315                 320 
Thr Tyr Tyr Phe Asn Lys Asn Met Asn Val Trp Val Asp Tyr Arg Phe
                325                 330                 335     
Asn Leu Leu Asp Glu Asn Asp Tyr Ser Ser Ser Tyr Val Gly Thr Asp
            340                 345                 350         
Asp Gln Ala Ala Val Gly Ile Thr Tyr Gln Phe
        355                 360             


<210> 22
<211> 1137
<212> DNA
<213> Salmonella typhi

<400> 22
atgaaagtta aagtactgtc cctcctggta ccagctctgc tggtggcggg cgcagcgaat 60
gcggctgaaa tttataataa agacggcaac aaattagacc tgtttggtaa agttgatggc 120
ctgcactact tctctgacga caaaggcagc gacggcgacc agacctacat gcgtatcggc 180
ttcaaaggcg aaacgcaggt taacgatcag ctgaccggtt atggccagtg ggaatatcag 240
attcagggca accagactga aggcagcaac gactcctgga cgcgtgtggc gtttgcgggt 300
ctgaaattcg ctgacgcagg ttccttcgat tatggtcgta actacggcgt aacctatgac 360
gtgacctcct ggaccgacgt tctgccggag ttcggcggcg acacctacgg cgctgacaac 420
tttatgcagc agcgtggtaa cggctatgct acctaccgta acaccgactt cttcggtctg 480
gtggatggtc tggacttcgc gttgcagtat cagggcaaaa acggcagcgt gagcggtgaa 540
aacaccaacg gtcgcagcct gctgaaccag aacggcgacg gttacggcgg atcgctgact 600
tatgcaatcg gcgaaggctt ctctgtcggt ggcgctatca ccacgtctaa acgtactgcc 660
gatcagaaca acaccgctaa cgctcgcctg tatggtaacg gcgatcgcgc cacggtttac 720
accggcggcc tgaaatacga tgcgaacaac atctatctgg cagcgcagta ttctcagacc 780
tataacgcaa cccgttttgg tacctctaac ggcagcaacc cgtccacctc ttacggtttt 840
gccaacaaag cgcagaactt tgaagtggtt gctcagtacc agttcgactt tggtctgcgt 900
ccgtctgtgg cttacctgca gtctaaaggt aaggacatca gcaacggcta cggcgccagc 960
tatggcgacc aggacatcgt aaaatacgtt gatgtcggcg cgacttacta cttcaacaaa 1020
aacatgtcca cctatgttga ttacaaaatc aacctgctgg ataaaaacga ctttacccgc 1080
gatgcgggca tcaacaccga cgacatcgta gcgctgggtc tggtttacca gttctaa    1137

<210> 23
<211> 1092
<212> DNA
<213> Salmonella typhi

<400> 23
atgatgaagc gcaaaatcct ggcagcggtg atccctgccc tgctggctgc tgcaaccgca 60
aacgcagcag aaatttataa taaagatggt aataagctgg atctgtacgg taaagccgtg 120
ggtcgtcacg tatggacaac gaccggcgat agtaaaaatg ccgaccagac ttatgcccag 180
attggtttta aaggggaaac gcagattaac accgatctga ccggtttcgg tcagtgggaa 240
taccgtacta aagcagaccg cgctgaaggc gaacagcaga actcgaatct ggtacgtctg 300
gctttcgcgg gtttgaaata cgcggaagtg ggttcaatcg attatggtcg taactacggt 360
atcgtttacg atgttgaatc ctataccgat atggccccct acttctccgg cgaaacctgg 420
ggcggcgcct ataccgataa ctacatgacc agccgtgctg gcggtttgtt gacctaccgt 480
aactctgact tctttggtct ggtggacggt ctctctttcg gtatccagta tcagggtaaa 540
aatcaggaca accacagcat taactctcag aatggcgatg gcgtaggtta caccatggca 600
tatgagttcg acggctttgg cgtcaccgca gcgtacagca acagcaagcg tactaacgat 660
cagcaggatc gcgatggtaa tggcgatcgc gcagaatcgt gggccgttgg cgcgaaatat 720
gatgcaaaca acgtctacct ggctgccgta tatgctgaaa cccgcaatat gagcattgtt 780
gaaaatacgg ttaccgatac cgtggaaatg gcaaacaaaa cgcagaacct ggaagtggtc 840
gctcagtacc agtttgactt cggcctgcgt ccggcaatct cgtatgtgca gagtaaaggt 900
aagcagttga acggcgccga cggctcggcc gatctggcga aatatattca ggcgggcgcg 960
acttactact tcaacaaaaa catgaacgta tgggttgact accgtttcaa cctgctggac 1020
gaaaacgact acagctccag ctacgttggc accgacgatc aggcggctgt cggtattact 1080
taccagttct ga                                                     1092
