                         SEQUENCE LISTING

<110>  Shayman, et al.
 
<120>  LYSOSOMAL PHOSPHOLIPASE A2 (LPLA2) ACTIVITY AS A DIAGNOSTIC AND 
       THERAPEUTIC TARGET FOR IDENTIFYING AND TREATING SYSTEMIC LUPUS 
       ERYTHEMATOSIS

<130>  30275/42363A

<150>  US-61/076,913
<151>  2008-06-30

<160>  290   

<170>  PatentIn version 3.5

<210>  1
<211>  412
<212>  PRT               
<213>  Homo sapiens

<400>  1

Met Gly Leu His Leu Arg Pro Tyr Arg Val Gly Leu Leu Pro Asp Gly 
1               5                   10                  15      


Leu Leu Phe Leu Leu Leu Leu Leu Met Leu Leu Ala Asp Pro Ala Leu 
            20                  25                  30          


Pro Ala Gly Arg His Pro Pro Val Val Leu Val Pro Gly Asp Leu Gly 
        35                  40                  45              


Asn Gln Leu Glu Ala Lys Leu Asp Lys Pro Thr Val Val His Tyr Leu 
    50                  55                  60                  


Cys Ser Lys Lys Thr Glu Ser Tyr Phe Thr Ile Trp Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Leu Leu Pro Val Ile Ile Asp Cys Trp Ile Asp Asn Ile Arg Leu 
                85                  90                  95      


Val Tyr Asn Lys Thr Ser Arg Ala Thr Gln Phe Pro Asp Gly Val Asp 
            100                 105                 110         


Val Arg Val Pro Gly Phe Gly Lys Thr Phe Ser Leu Glu Phe Leu Asp 
        115                 120                 125             


Pro Ser Lys Ser Ser Val Gly Ser Tyr Phe His Thr Met Val Glu Ser 
    130                 135                 140                 


Leu Val Gly Trp Gly Tyr Thr Arg Gly Glu Asp Val Arg Gly Ala Pro 
145                 150                 155                 160 


Tyr Asp Trp Arg Arg Ala Pro Asn Glu Asn Gly Pro Tyr Phe Leu Ala 
                165                 170                 175     


Leu Arg Glu Met Ile Glu Glu Met Tyr Gln Leu Tyr Gly Gly Pro Val 
            180                 185                 190         


Val Leu Val Ala His Ser Met Gly Asn Met Tyr Thr Leu Tyr Phe Leu 
        195                 200                 205             


Gln Arg Gln Pro Gln Ala Trp Lys Asp Lys Tyr Ile Arg Ala Phe Val 
    210                 215                 220                 


Ser Leu Gly Ala Pro Trp Gly Gly Val Ala Lys Thr Leu Arg Val Leu 
225                 230                 235                 240 


Ala Ser Gly Asp Asn Asn Arg Ile Pro Val Ile Gly Pro Leu Lys Ile 
                245                 250                 255     


Arg Glu Gln Gln Arg Ser Ala Val Ser Thr Ser Trp Leu Leu Pro Tyr 
            260                 265                 270         


Asn Tyr Thr Trp Ser Pro Glu Lys Val Phe Val Gln Thr Pro Thr Ile 
        275                 280                 285             


Asn Tyr Thr Leu Arg Asp Tyr Arg Lys Phe Phe Gln Asp Ile Gly Phe 
    290                 295                 300                 


Glu Asp Gly Trp Leu Met Arg Gln Asp Thr Glu Gly Leu Val Glu Ala 
305                 310                 315                 320 


Thr Met Pro Pro Gly Val Gln Leu His Cys Leu Tyr Gly Thr Gly Val 
                325                 330                 335     


Pro Thr Pro Asp Ser Phe Tyr Tyr Glu Ser Phe Pro Asp Arg Asp Pro 
            340                 345                 350         


Lys Ile Cys Phe Gly Asp Gly Asp Gly Thr Val Asn Leu Lys Ser Ala 
        355                 360                 365             


Leu Gln Cys Gln Ala Trp Gln Ser Arg Gln Glu His Gln Val Leu Leu 
    370                 375                 380                 


Gln Glu Leu Pro Gly Ser Glu His Ile Glu Met Leu Ala Asn Ala Thr 
385                 390                 395                 400 


Thr Leu Ala Tyr Leu Lys Arg Val Leu Leu Gly Pro 
                405                 410         


<210>  2
<211>  123
<212>  PRT
<213>  Ovis aries

<400>  2

Ala Leu Trp Gln Phe Asn Gly Met Ile Lys Cys Lys Ile Pro Ser Ser 
1               5                   10                  15      


Glu Pro Leu Leu Asp Phe Asn Asn Tyr Gly Cys Tyr Cys Gly Leu Gly 
            20                  25                  30          


Gly Ser Gly Thr Pro Val Asp Asp Leu Asp Arg Cys Cys Gln Thr His 
        35                  40                  45              


Asp Asn Cys Tyr Lys Gln Ala Lys Lys Leu Asp Ser Cys Lys Val Leu 
    50                  55                  60                  


Val Asp Asn Pro Tyr Thr Asn Ser Tyr Ser Tyr Ser Cys Ser Asn Lys 
65                  70                  75                  80  


Gln Ile Thr Cys Ser Ser Glu Asn Asn Ala Cys Glu Ala Phe Ile Cys 
                85                  90                  95      


Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe Ser Glu Val Pro Tyr Asn 
            100                 105                 110         


Asn Glu His Lys Asn Leu Asp Lys Lys Tyr Cys 
        115                 120             


<210>  3
<211>  146
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Lys Val Leu Leu Leu Leu Ala Val Val Ile Met Ala Phe Gly Ser 
1               5                   10                  15      


Ile Gln Val Gln Gly Ser Leu Leu Glu Phe Gly Gln Met Ile Leu Phe 
            20                  25                  30          


Lys Thr Gly Lys Arg Ala Asp Val Ser Tyr Gly Phe Tyr Gly Cys His 
        35                  40                  45              


Cys Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Trp Cys 
    50                  55                  60                  


Cys Val Thr His Asp Cys Cys Tyr Asn Arg Leu Glu Lys Arg Gly Cys 
65                  70                  75                  80  


Gly Thr Lys Phe Val Thr Tyr Lys Phe Ser Tyr Arg Gly Gly Gln Ile 
                85                  90                  95      


Ser Cys Ser Thr Asn Gln Asp Ser Cys Arg Lys Gln Leu Cys Gln Cys 
            100                 105                 110         


Asp Lys Ala Ala Ala Glu Cys Phe Ala Arg Asn Lys Lys Ser Tyr Ser 
        115                 120                 125             


Leu Lys Tyr Gln Phe Tyr Pro Asn Lys Phe Cys Lys Gly Lys Thr Pro 
    130                 135                 140                 


Ser Cys 
145     


<210>  4
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Val Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu His Ile Arg Glu Ser Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Asn Ser Glu Gly Leu His Ser Ala Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
305                 310                 315                 320 


Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Ser Arg Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Thr Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ser His Glu Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Gly Ser Asp Tyr Gln Ser Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Ile His Arg Met Ile Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Ser Asp Phe Ala Thr 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Met Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Pro 
                645                 650                 655     


Arg Glu Thr Glu Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Glu Ala Met Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Arg Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Lys Ala 
            740                 745                 


<210>  5
<211>  1487
<212>  PRT
<213>  Mus musculus

<400>  5

Met Val Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu Gln Gln Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ile His Gln Gly Ile Ala Gln Asp Leu Thr His Ile 
            20                  25                  30          


Gln Glu Pro Ser Leu Glu Trp Arg Asp Lys Gly Ile Phe Ile Ile Gln 
        35                  40                  45              


Ser Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser Val Leu Thr 
    50                  55                  60                  


Leu Glu Asn Cys Lys Gln Pro Asn Glu His Met Leu Trp Lys Trp Val 
65                  70                  75                  80  


Ser Asp Asp His Leu Phe Asn Val Gly Gly Ser Gly Cys Leu Gly Leu 
                85                  90                  95      


Asn Ile Ser Ala Leu Glu Gln Pro Leu Lys Leu Tyr Glu Cys Asp Ser 
            100                 105                 110         


Thr Leu Ile Ser Leu Arg Trp His Cys Asp Arg Lys Met Ile Glu Gly 
        115                 120                 125             


Pro Leu Gln Tyr Lys Val Gln Val Lys Ser Asp Asn Thr Val Val Ala 
    130                 135                 140                 


Arg Lys Gln Ile His Arg Trp Ile Ala Tyr Thr Ser Ser Gly Gly Asp 
145                 150                 155                 160 


Ile Cys Glu His Pro Ser Arg Asp Leu Tyr Thr Leu Lys Gly Asn Ala 
                165                 170                 175     


His Gly Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly His Trp His 
            180                 185                 190         


His Asp Cys Ile Arg Glu Gly Gln Lys Glu His Leu Leu Trp Cys Ala 
        195                 200                 205             


Thr Thr Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe Cys Pro Asp 
    210                 215                 220                 


Pro Thr Ser Met Lys Val Phe Cys Asp Ala Thr Trp Gln Arg Asn Gly 
225                 230                 235                 240 


Ser Ser Arg Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp 
                245                 250                 255     


Asn Gln Ala His Ser Ser Cys Leu Met Gln Gly Gly Ala Leu Leu Ser 
            260                 265                 270         


Ile Ala Asp Glu Asp Glu Glu Asp Phe Ile Arg Lys His Leu Ser Lys 
        275                 280                 285             


Val Val Lys Glu Val Trp Ile Gly Leu Asn Gln Leu Asp Glu Lys Ala 
    290                 295                 300                 


Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser 
305                 310                 315                 320 


Gln Glu Ile Thr Pro Gly Pro Phe Val Glu His His Cys Gly Thr Leu 
                325                 330                 335     


Glu Val Val Ser Ala Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu 
            340                 345                 350         


Pro Tyr Ile Cys Lys Arg Asp Leu Asn His Thr Ala Gln Gly Ile Leu 
        355                 360                 365             


Glu Lys Asp Ser Trp Lys Tyr His Ala Thr His Cys Asp Pro Asp Trp 
    370                 375                 380                 


Thr Pro Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Asp Arg Lys Ser 
385                 390                 395                 400 


Trp Leu Gly Ala Leu His Ser Cys Gln Ser Asn Asp Ser Val Leu Met 
                405                 410                 415     


Asp Val Ala Ser Leu Ala Glu Val Glu Phe Leu Val Ser Leu Leu Arg 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Ser Gly Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp Tyr Pro Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Glu Ser Asp Gly Arg Trp Lys Val Lys Asp Cys Lys 
                485                 490                 495     


Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly Gln Val Pro Ala Asp 
            500                 505                 510         


Glu Gln Ser Gly Cys Pro Ala Gly Trp Glu Arg His Gly Arg Phe Cys 
        515                 520                 525             


Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Glu Glu Ala Ser Ser Gly 
    530                 535                 540                 


Tyr Tyr Cys Ser Pro Ala Leu Leu Thr Ile Thr Ser Arg Phe Glu Gln 
545                 550                 555                 560 


Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Ala Glu Lys Asp Ser Tyr 
                565                 570                 575     


Phe Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp 
            580                 585                 590         


Lys Thr Val Gly Gln Arg Glu Pro Val Gln Tyr Thr Tyr Trp Asn Thr 
        595                 600                 605             


Arg Gln Pro Ser Asn Arg Gly Gly Cys Val Val Val Arg Gly Gly Ser 
    610                 615                 620                 


Ser Leu Gly Arg Trp Glu Val Lys Asp Cys Ser Asp Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Thr Pro Val Lys Ile Trp Glu Lys Thr Glu Leu Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu Ser Ala Thr 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Arg Arg Asn Pro Leu Asn Ala Gly Ser Trp Ala Trp Ser 
            740                 745                 750         


Asp Gly Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala Tyr Phe Glu 
        755                 760                 765             


Glu Asp Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Ser Asn Cys Ala Ser Lys His Glu Trp Ile Cys Arg Ile Pro Arg 
785                 790                 795                 800 


Asp Val Arg Pro Lys Phe Pro Asp Trp Tyr Gln Tyr Asp Ala Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His Pro Ala Glu 
            820                 825                 830         


Trp Ala Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Phe Leu 
        835                 840                 845             


Thr Ile Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Gly Leu Thr Lys Tyr Gly Val Lys Trp Trp Ile Gly Leu Glu Glu Gly 
865                 870                 875                 880 


Gly Ala Arg Asp Gln Ile Gln Trp Ser Asn Gly Ser Pro Val Ile Phe 
                885                 890                 895     


Gln Asn Trp Asp Lys Gly Arg Glu Glu Arg Val Asp Ser Gln Arg Lys 
            900                 905                 910         


Arg Cys Val Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Thr Glu Asn 
        915                 920                 925             


Cys Ser Val Pro Leu Pro Ser Ile Cys Lys Arg Val Lys Ile Trp Val 
    930                 935                 940                 


Ile Glu Lys Glu Lys Pro Pro Thr Gln Pro Gly Thr Cys Pro Lys Gly 
945                 950                 955                 960 


Trp Leu Tyr Phe Asn Tyr Lys Cys Phe Leu Val Thr Ile Pro Lys Asp 
                965                 970                 975     


Pro Arg Glu Leu Lys Thr Trp Thr Gly Ala Gln Glu Phe Cys Val Ala 
            980                 985                 990         


Lys Gly Gly Thr Leu Val Ser Ile  Lys Ser Glu Leu Glu  Gln Ala Phe 
        995                 1000                 1005             


Ile Thr  Met Asn Leu Phe Gly  Gln Thr Thr Asn Val  Trp Ile Gly 
    1010                 1015                 1020             


Leu Gln  Ser Thr Asn His Glu  Lys Trp Val Asn Gly  Lys Pro Leu 
    1025                 1030                 1035             


Val Tyr  Ser Asn Trp Ser Pro  Ser Asp Ile Ile Asn  Ile Pro Ser 
    1040                 1045                 1050             


Tyr Asn  Thr Thr Glu Phe Gln  Lys His Ile Pro Leu  Cys Ala Leu 
    1055                 1060                 1065             


Met Ser  Ser Asn Pro Asn Phe  His Phe Thr Gly Lys  Trp Tyr Phe 
    1070                 1075                 1080             


Asp Asp  Cys Gly Lys Glu Gly  Tyr Gly Phe Val Cys  Glu Lys Met 
    1085                 1090                 1095             


Gln Asp  Thr Leu Glu His His  Val Asn Val Ser Asp  Thr Ser Ala 
    1100                 1105                 1110             


Ile Pro  Ser Thr Leu Glu Tyr  Gly Asn Arg Thr Tyr  Lys Ile Ile 
    1115                 1120                 1125             


Arg Gly  Asn Met Thr Trp Tyr  Ala Ala Gly Lys Ser  Cys Arg Met 
    1130                 1135                 1140             


His Arg  Ala Glu Leu Ala Ser  Ile Pro Asp Ala Phe  His Gln Ala 
    1145                 1150                 1155             


Phe Leu  Thr Val Leu Leu Ser  Arg Leu Gly His Thr  His Trp Ile 
    1160                 1165                 1170             


Gly Leu  Ser Thr Thr Asp Asn  Gly Gln Thr Phe Asp  Trp Ser Asp 
    1175                 1180                 1185             


Gly Thr  Lys Ser Pro Phe Thr  Tyr Trp Lys Asp Glu  Glu Ser Ala 
    1190                 1195                 1200             


Phe Leu  Gly Asp Cys Ala Phe  Ala Asp Thr Asn Gly  Arg Trp His 
    1205                 1210                 1215             


Ser Thr  Ala Cys Glu Ser Phe  Leu Gln Gly Ala Ile  Cys His Val 
    1220                 1225                 1230             


Val Thr  Glu Thr Lys Ala Phe  Glu His Pro Gly Leu  Cys Ser Glu 
    1235                 1240                 1245             


Thr Ser  Val Pro Trp Ile Lys  Phe Lys Gly Asn Cys  Tyr Ser Phe 
    1250                 1255                 1260             


Ser Thr  Val Leu Asp Ser Arg  Ser Phe Glu Asp Ala  His Glu Phe 
    1265                 1270                 1275             


Cys Lys  Ser Glu Gly Ser Asn  Leu Leu Ala Ile Arg  Asp Ala Ala 
    1280                 1285                 1290             


Glu Asn  Ser Phe Leu Leu Glu  Glu Leu Leu Ala Phe  Gly Ser Ser 
    1295                 1300                 1305             


Val Gln  Met Val Trp Leu Asn  Ala Gln Phe Asp Asn  Asn Asn Lys 
    1310                 1315                 1320             


Thr Leu  Arg Trp Phe Asp Gly  Thr Pro Thr Glu Gln  Ser Asn Trp 
    1325                 1330                 1335             


Gly Leu  Arg Lys Pro Asp Met  Asp His Leu Lys Pro  His Pro Cys 
    1340                 1345                 1350             


Val Val  Leu Arg Ile Pro Glu  Gly Ile Trp His Phe  Thr Pro Cys 
    1355                 1360                 1365             


Glu Asp  Lys Lys Gly Phe Ile  Cys Lys Met Glu Ala  Gly Ile Pro 
    1370                 1375                 1380             


Ala Val  Thr Ala Gln Pro Glu  Lys Gly Leu Ser His  Ser Ile Val 
    1385                 1390                 1395             


Pro Val  Thr Val Thr Leu Thr  Leu Ile Ile Ala Leu  Gly Ile Phe 
    1400                 1405                 1410             


Met Leu  Cys Phe Trp Ile Tyr  Lys Gln Lys Ser Asp  Ile Phe Gln 
    1415                 1420                 1425             


Arg Leu  Thr Gly Ser Arg Gly  Ser Tyr Tyr Pro Thr  Leu Asn Phe 
    1430                 1435                 1440             


Ser Thr  Ala His Leu Glu Glu  Asn Ile Leu Ile Ser  Asp Leu Glu 
    1445                 1450                 1455             


Lys Asn  Thr Asn Asp Glu Glu  Val Arg Asp Ala Pro  Ala Thr Glu 
    1460                 1465                 1470             


Ser Lys  Arg Gly His Lys Gly  Arg Pro Ile Cys Ile  Ser Pro 
    1475                 1480                 1485         


<210>  6
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


<210>  7
<211>  752
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Thr Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Pro Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Ile Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Arg Gln 
145                 150                 155                 160 


Arg Lys Glu Asn Ile Lys Glu Asn Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Lys Ser Glu Gly Leu Tyr Ser Thr Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


Gln Asn Arg Met Ser Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Ser 
305                 310                 315                 320 


Ala Ala Arg Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Thr Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Asn Lys Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Ala Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ala Gln Gly Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Glu Arg Glu Tyr Gln Asn Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Val His Arg Met Leu Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Glu His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Arg Asp Phe Ser Pro 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Thr Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Val Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Leu 
                645                 650                 655     


Arg Glu Thr Lys Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met Tyr Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Asp Ala Ile Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Lys Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Thr Ala Glu Ser Ile 
            740                 745                 750         


<210>  8
<211>  1463
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  9
<211>  132
<212>  PRT
<213>  Equus caballus

<400>  9

Glu Asn Gly Ile Ser Pro Arg Ala Val Trp Gln Phe Arg Ser Met Ile 
1               5                   10                  15      


Gln Cys Thr Ile Pro Asn Ser Lys Pro Tyr Leu Glu Phe Asn Asp Tyr 
            20                  25                  30          


Gly Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu 
        35                  40                  45              


Asp Ala Cys Cys Gln Val His Asp Asn Cys Tyr Thr Gln Ala Lys Glu 
    50                  55                  60                  


Leu Ser Ser Cys Arg Phe Leu Val Asp Asn Pro Tyr Thr Glu Ser Tyr 
65                  70                  75                  80  


Lys Phe Ser Cys Ser Gly Thr Glu Val Thr Cys Ser Asp Lys Asn Asn 
                85                  90                  95      


Ala Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys 
            100                 105                 110         


Phe Ser Lys Ala Pro Tyr Asn Pro Glu Asn Lys Asn Leu Asp Ser Lys 
        115                 120                 125             


Arg Lys Cys Ala 
    130         


<210>  10
<211>  748
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Thr Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Pro Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Ile Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu Asn Ile Lys Glu Asn Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Lys Ser Glu Gly Leu Tyr Ser Thr Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Ile 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


Gln Asn Arg Met Ser Met Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
305                 310                 315                 320 


Ala Ala Arg Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Asn Lys Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Ala Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ala Gln Gly Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Glu Ala Glu Lys Glu Tyr Gln Ser Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Val His Arg Met Leu Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Arg Asp Phe Ser Ser 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro Asp 
        515                 520                 525             


Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys Ile 
    530                 535                 540                 


His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu Ile 
545                 550                 555                 560 


Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe Ser 
                565                 570                 575     


Ala Arg Pro Ser Asp Thr Ser Pro Pro Phe Lys Glu Leu Leu Leu Ala 
            580                 585                 590         


Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp Pro 
        595                 600                 605             


Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys Pro 
    610                 615                 620                 


Lys Asn Pro Asp Val Glu Lys Asp Cys Pro Thr Ile Ile His Phe Val 
625                 630                 635                 640 


Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Leu Arg 
                645                 650                 655     


Glu Thr Lys Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp Asp 
            660                 665                 670         


Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln Ala 
        675                 680                 685             


Phe Lys Arg Leu His Asp Leu Met Tyr Phe Asn Thr Leu Asn Asn Ile 
    690                 695                 700                 


Asp Val Ile Lys Asp Ala Ile Val Glu Ser Ile Glu Tyr Arg Arg Gln 
705                 710                 715                 720 


Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg Lys 
                725                 730                 735     


Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Thr Val 
            740                 745             


<210>  11
<211>  1463
<212>  PRT
<213>  Bos taurus

<400>  11

Met Pro Leu Leu Ser Leu Ser Leu Leu Leu Leu Leu Leu Gln Val Pro 
1               5                   10                  15      


Ala Gly Ser Ala Glu Thr Ala Ala Trp Ala Val Thr Pro Glu Arg Leu 
            20                  25                  30          


Arg Glu Trp Gln Asp Lys Gly Ile Phe Ile Ile Gln Ser Glu Asn Leu 
        35                  40                  45              


Glu Lys Cys Ile Gln Ala Ser Lys Ser Thr Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Pro Pro Asn Lys Tyr Met Leu Trp Lys Trp Val Ser Asn His Arg 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Val Ser Ser 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Ile Tyr Glu Cys Asp Ser Thr His Val Ser 
            100                 105                 110         


Leu Lys Trp His Cys Asn Lys Lys Thr Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Leu Val Gln Val Lys Gln Asp Asn Thr Leu Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Leu His Lys Trp Val Ser Tyr Met Ser Gly Gly Gly Gly Ile Cys Asp 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu Tyr Thr Ile Lys Gly Asn Ala His Gly Thr 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn Gln Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asn Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Thr Glu Val Gly Cys Asp Ala Val Trp Glu Lys Asp Leu His Ser Arg 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Ala Ala Leu Leu Ser Ile Ala Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Val Arg Lys His Leu Gly Ser Glu Ala Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Arg Thr Pro Leu Asn Tyr Leu Asn Trp Lys Pro Glu Ile 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Tyr His Cys Gly Thr Phe Asn Ala Phe 
                325                 330                 335     


Met Pro Lys Ala Trp Lys Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Val Cys Lys Lys Tyr Leu Asn Pro Thr Asp His Gly Val Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


His Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Lys Lys Thr Trp Asn 
385                 390                 395                 400 


Glu Ala Leu Gln Ser Cys Gln Ser Asn Asn Ser Val Leu Thr Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser His Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Gly Ser Ser Val Thr Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Thr 
                485                 490                 495     


Leu Phe Tyr Leu Cys Lys Lys Thr Gly Leu Val Leu Ser Asp Thr Glu 
            500                 505                 510         


Ser Gly Cys Gln Lys Gly Trp Glu Arg His Gly Lys Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp His Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Ile Thr Ile Thr Ser Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Thr Lys Asp Thr Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Thr Ala Gly Gln Gln Leu Glu Pro Val Lys Tyr Thr His Trp Asn Thr 
        595                 600                 605             


Arg Gln Pro Arg Tyr Ser Gly Gly Cys Val Val Met Arg Gly Arg Ser 
    610                 615                 620                 


His Pro Gly Arg Trp Glu Val Arg Asp Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Arg Glu Lys Thr Lys Gln Glu 
                645                 650                 655     


Glu Gly Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Gln Ala Glu Glu Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Arg Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Gly Thr Pro Val Val Ser Ser Phe Leu Asp Asn Ser Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Ser Tyr Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Arg Pro Lys Val Pro Pro Trp Tyr Gln Tyr Asp Ala Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Ile Ser Ala Ser Glu 
            820                 825                 830         


Trp Ser Ser Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Ile Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Arg 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Val Asn Trp Trp Ile Gly Leu Arg Glu Glu 
865                 870                 875                 880 


Arg Ala Ser Asp Glu Phe Arg Trp Arg Asp Gly Ser Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Lys Gly Lys Glu Arg Ser Met Gly Leu Asn Glu Ser 
            900                 905                 910         


Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Ala Ser Glu 
        915                 920                 925             


Glu Cys Ser Ile Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp 
    930                 935                 940                 


Val Ile Glu Lys Lys Lys Asp Ile Pro Lys Gln His Gly Thr Cys Pro 
945                 950                 955                 960 


Lys Gly Trp Leu Tyr Phe Asp Tyr Lys Cys Leu Leu Leu Lys Ile Pro 
                965                 970                 975     


Glu Gly Pro Ser Asp Trp Lys Asn Trp Thr Ser Ala Gln Asp Phe Cys 
            980                 985                 990         


Val Glu Glu Gly Gly Thr Leu Val  Ala Ile Glu Asn Glu  Val Glu Gln 
        995                 1000                 1005             


Ala Phe  Ile Thr Met Asn Leu  Phe Gly His Thr Thr  Asn Val Trp 
    1010                 1015                 1020             


Ile Gly  Leu Gln Asp Asp Asp  Tyr Glu Lys Trp Leu  Asn Gly Arg 
    1025                 1030                 1035             


Pro Val  Ser Tyr Ser Asn Trp  Ser Pro Phe Asp Thr  Lys Asn Ile 
    1040                 1045                 1050             


Pro Asn  His Asn Thr Thr Glu  Val Gln Lys Arg Ile  Pro Leu Cys 
    1055                 1060                 1065             


Gly Leu  Leu Ser Asn Asn Pro  Asn Phe His Phe Thr  Gly Lys Trp 
    1070                 1075                 1080             


Tyr Phe  Glu Asp Cys Arg Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Ala Ser Gly His  Ser Ile Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Ile  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Thr Ala Leu Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Gly Ala Glu Leu Ala  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Ile Leu  Asn Arg Val Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Glu Asp  Asn Gly Leu Ser Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Asp Glu Ser 
    1190                 1195                 1200             


Ser Phe  Leu Gly Asp Cys Val  Phe Ala Asp Thr Ser  Gly Arg Trp 
    1205                 1210                 1215             


Ser Ser  Thr Ala Cys Glu Ser  Tyr Leu Gln Gly Ala  Ile Cys Gln 
    1220                 1225                 1230             


Val Pro  Thr Glu Thr Arg Leu  Ser Gly Arg Leu Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Glu Ser  Thr Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Lys Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ser Phe Leu Leu  Glu Glu Leu Leu Ala  Phe Arg Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Ile Trp Leu  Asn Ala Gln Phe Asp  Gly Asp Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Glu  Val Tyr His Phe Lys  Pro His Leu 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Val Trp Gln  Leu Ser Ser 
    1355                 1360                 1365             


Cys Gln  Asp Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Val Lys Lys His Pro  Gly Lys Gly Pro Ser  His Ser Val 
    1385                 1390                 1395             


Ile Pro  Leu Thr Val Ala Leu  Thr Leu Leu Val Ile  Leu Ala Ile 
    1400                 1405                 1410             


Ser Thr  Leu Ser Phe Cys Met  Tyr Lys His Ser His  Ile Ile Phe 
    1415                 1420                 1425             


Gly Arg  Leu Ala Gln Phe Arg  Asn Pro Tyr Tyr Pro  Ser Ala Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val His Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Asn Asp Gln 
    1460             


<210>  12
<211>  749
<212>  PRT
<213>  Equus caballus

<400>  12

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Ser Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asn Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Leu Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Ile Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu Asn Ile Lys Glu Asn Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Lys Ser Glu Gly Leu Tyr Ser Thr Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Leu 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Ser Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Lys Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser Tyr Asp Pro Leu Leu Leu Leu Thr Pro Gln Lys Ile 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
305                 310                 315                 320 


Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Asn Lys Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Ala Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ser Gln Glu Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Glu Arg Asp Tyr Gln Asn Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Val His Arg Met Leu Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Arg Asn Phe Thr Thr 
            500                 505                 510         


Gln Glu Ser Leu Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Val Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Pro 
                645                 650                 655     


Arg Glu Thr Lys Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Asn Ala Met Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Arg Phe Phe Asn Lys Glu Phe Leu Asn Lys Pro Thr Ala 
            740                 745                 


<210>  13
<211>  1458
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  13

Met Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro Arg Arg 
1               5                   10                  15      


Cys Thr Glu Gly Ala Ala Ala Ala Leu Ser Pro Glu Arg Val Leu Lys 
            20                  25                  30          


Trp Gln Glu Lys Gly Ile Phe Ile Ile Gln Ser Glu Ser Leu Lys Ser 
        35                  40                  45              


Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Ser Cys Lys Gln 
    50                  55                  60                  


Pro Asn Lys Asn Met Leu Trp Lys Trp Val Ser Asn Gln His Leu Phe 
65                  70                  75                  80  


Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Leu Ser Asn Pro Glu 
                85                  90                  95      


Gln Pro Leu Gly Leu Tyr Glu Cys Asp Ser Thr His Val Ser Leu Arg 
            100                 105                 110         


Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln His Thr Val 
        115                 120                 125             


Gln Val Lys Gln Asp Asn Ile Ile Val Ala Ser Gly Lys Arg Leu His 
    130                 135                 140                 


Lys Trp Ile Ser Tyr Met Ser Asp Ser Gly Asp Ile Cys Gln His Val 
145                 150                 155                 160 


His Lys Asp Leu Tyr Thr Arg Lys Gly Asn Ala His Gly Thr Pro Cys 
                165                 170                 175     


Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg 
            180                 185                 190         


Glu Gly Arg Gln Asp Asp Ser Leu Trp Cys Ala Thr Thr Ser Arg Tyr 
        195                 200                 205             


Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu 
    210                 215                 220                 


Val Gly Cys Asp Ala Val Trp Glu Lys Asp Leu Asn Ser His Ile Cys 
225                 230                 235                 240 


Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser 
                245                 250                 255     


Ser Cys Gln Met His Gly Gly Ala Leu Leu Ser Ile Val Asp Glu Ala 
            260                 265                 270         


Glu Glu Asn Phe Ile Arg Lys Gln Val Ser Gly Glu Ala Val Glu Val 
        275                 280                 285             


Trp Thr Gly Leu Asn Gln Leu Asp Val Asn Ala Gly Trp Gln Trp Ser 
    290                 295                 300                 


Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser Pro Glu Ile Ser Phe 
305                 310                 315                 320 


Glu Pro Phe Val Glu Tyr His Cys Gly Thr Phe Asn Ser Phe Met Pro 
                325                 330                 335     


Arg Ala Trp Arg Ser Arg Asn Cys Glu Ser Thr Leu Pro Tyr Ile Cys 
            340                 345                 350         


Lys Lys Tyr Leu Asn His Val Asp Asp Glu Ile Val Glu Lys Asp Ala 
        355                 360                 365             


Trp Lys Tyr Tyr Ala Thr Asp Cys Glu Pro Gly Trp Ala Pro Tyr His 
    370                 375                 380                 


Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp Asn Glu Ala 
385                 390                 395                 400 


Leu His Ser Cys Leu Ser Ser Asn Ser Thr Leu Ile Asp Ile Gly Ser 
                405                 410                 415     


Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asn Glu Asn Ala 
            420                 425                 430         


Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Thr Phe Pro Val Ser Phe 
        435                 440                 445             


Glu Trp Ser Asn Gly Ser Ser Val Ile Phe Thr Asn Trp His Thr Leu 
    450                 455                 460                 


Glu Pro Gln Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser Ala Glu 
465                 470                 475                 480 


Gln Ser Glu Gly His Trp Lys Val Thr Asp Cys Glu Glu Thr His Phe 
                485                 490                 495     


Tyr Val Cys Lys Lys Pro Gly His Val Leu Ser Asp Ala Glu Ser Gly 
            500                 505                 510         


Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys Ile Asp 
        515                 520                 525             


Thr Val Leu Arg Ser Phe Asp His Ala Ser Ser Gly Tyr Tyr Cys Pro 
    530                 535                 540                 


Pro Ala Leu Val Thr Ile Ala Asp Arg Phe Glu Gln Ala Phe Ile Thr 
545                 550                 555                 560 


Ser Leu Ile Ser Ser Val Val Asn Met Lys Asp Ser Tyr Phe Trp Ile 
                565                 570                 575     


Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys Thr Ala 
            580                 585                 590         


Gly Gln Lys Ser Glu Pro Val Gln Tyr Thr His Trp Asn Ala His Gln 
        595                 600                 605             


Pro Arg Ser Ser Gly Gly Cys Val Ala Ile Arg Gly Arg Asn Pro Ile 
    610                 615                 620                 


Gly Arg Trp Glu Val Lys Asp Cys Val His Phe Lys Ala Met Ser Leu 
625                 630                 635                 640 


Cys Lys Gln Pro Val Glu Thr Arg Glu Lys Met Glu His Glu Glu Arg 
                645                 650                 655     


Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Gln Pro Gly Leu 
            660                 665                 670         


Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met Lys Arg 
        675                 680                 685             


Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala His Leu 
    690                 695                 700                 


Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu Leu Leu 
705                 710                 715                 720 


His Pro Lys Phe Asn Arg Ser Glu Glu Arg Gln Phe Trp Ile Gly Phe 
                725                 730                 735     


Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser Asp Gly 
            740                 745                 750         


Thr Pro Val Ile Ser Ser Phe Leu Asp Asn Asn Tyr Phe Gly Glu Asp 
        755                 760                 765             


Thr Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu Pro Leu 
    770                 775                 780                 


His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg Asp Val 
785                 790                 795                 800 


Arg Pro Lys Ile Pro Ser Trp Tyr Gln Tyr Asp Ala Pro Trp Leu Phe 
                805                 810                 815     


His Gln Asp Ala Glu Tyr Leu Phe Tyr Pro His Ser Ser Glu Trp Ser 
            820                 825                 830         


Ser Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Ile Leu Thr Ile 
        835                 840                 845             


His Ser Ala His Glu Gln Glu Phe Ile Leu Ser Lys Ile Lys Ala Leu 
    850                 855                 860                 


Ser Lys Tyr Gly Ala Asn Trp Trp Ile Gly Leu Gln Glu Glu Thr Ala 
865                 870                 875                 880 


Asn Asp Glu Leu Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr Gln Asn 
                885                 890                 895     


Trp Asp Lys Glu Arg Asp Arg Ser Met Asn Asn Gln Ser Gln Arg Cys 
            900                 905                 910         


Ala Phe Ile Ser Ser Ile Thr Gly Leu Trp Asp Arg Glu Glu Cys Ser 
        915                 920                 925             


Val Ser Met Pro Ser Ile Cys Lys Arg Lys Thr Phe Trp Val Ile Glu 
    930                 935                 940                 


Lys Glu Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys Gly Trp 
945                 950                 955                 960 


Leu Tyr Phe Asp Tyr Lys Cys Leu Leu Val Asn Val Pro Lys Asp Pro 
                965                 970                 975     


Ser Asn Trp Lys Asn Trp Thr Gln Ala Arg Asp Phe Cys Phe Asp Glu 
            980                 985                 990         


Gly Gly Thr Leu Val Ala Ile Glu  Ser Glu Val Glu Gln  Ala Phe Ile 
        995                 1000                 1005             


Thr Met  Asn Leu Phe Gly Gln  Thr Thr Asn Val Trp  Ile Gly Leu 
    1010                 1015                 1020             


Gln Asn  Asp Asp Tyr Glu Lys  Trp Leu Asn Gly Asn  Pro Val Ala 
    1025                 1030                 1035             


Tyr Ser  Asn Trp Ser Pro Ser  Asp Ile Ile Asn Ile  Pro Ser Tyr 
    1040                 1045                 1050             


Asn Thr  Thr Ala Asp Gln Lys  Pro Ile Pro Leu Cys  Ala Leu Leu 
    1055                 1060                 1065             


Ser Ser  Asn Pro Asn Phe His  Phe Thr Gly Lys Trp  Tyr Phe Glu 
    1070                 1075                 1080             


Asp Cys  Gly Lys Glu Gly Tyr  Gly Phe Val Cys Glu  Lys Ile Gln 
    1085                 1090                 1095             


Asp Ser  Ala Gly His Glu Val  Asn Thr Ser Ile Met  Asp Pro Ile 
    1100                 1105                 1110             


Pro Asn  Thr Leu Glu Tyr Gly  Asn Arg Thr Tyr Lys  Ile Ile Asn 
    1115                 1120                 1125             


Ala Asn  Met Thr Trp Tyr Ala  Ala Ile Lys Ser Cys  Gln Leu His 
    1130                 1135                 1140             


Gly Ala  Glu Leu Val Ser Ile  Thr Asp Gln Tyr His  Gln Ser Phe 
    1145                 1150                 1155             


Leu Thr  Val Ile Leu Ser Arg  Leu Gly His Ala His  Trp Ile Gly 
    1160                 1165                 1170             


Leu Phe  Thr Ala Asp Asn Gly  Leu His Phe Asp Trp  Ser Asp Gly 
    1175                 1180                 1185             


Thr Lys  Ser Ser Phe Thr Phe  Trp Lys Asp Glu Asp  Ser Ser Phe 
    1190                 1195                 1200             


Leu Gly  Asp Cys Val Phe Ala  Asp Thr Ser Gly Arg  Trp His Ser 
    1205                 1210                 1215             


Thr Ala  Cys Glu Ser Phe Leu  Gln Gly Ala Ile Cys  His Val Pro 
    1220                 1225                 1230             


Thr Glu  Thr Arg Pro Phe Glu  His Pro Glu Leu Cys  Ser Glu Thr 
    1235                 1240                 1245             


Ser Ile  Pro Trp Ile Lys Phe  Lys Ser Asn Cys Tyr  Ser Phe Ser 
    1250                 1255                 1260             


Thr Val  Leu His Ser Ala Ser  Phe Glu Ala Ala His  Glu Phe Cys 
    1265                 1270                 1275             


Lys Lys  Glu Gly Ser Asn Leu  Leu Thr Ile Lys Asp  Glu Ala Glu 
    1280                 1285                 1290             


Asn Ser  Phe Leu Leu Glu Glu  Pro Phe Ala Phe Gly  Ala Ser Val 
    1295                 1300                 1305             


Gln Met  Val Trp Leu Asn Ala  Gln Phe Asp Asn Glu  Thr Val Lys 
    1310                 1315                 1320             


Trp Leu  Asp Gly Thr Pro Ala  Asp Gln Ser Asn Trp  Gly Ile Arg 
    1325                 1330                 1335             


Lys Pro  Asp Met Ala His Phe  Glu Pro His Gln Cys  Leu Ala Leu 
    1340                 1345                 1350             


Arg Ile  Pro Glu Gly Val Trp  Gln Leu Ser Pro Cys  Gln Lys Asn 
    1355                 1360                 1365             


Met Gly  Phe Ile Cys Lys Met  Lys Ala Asp Ile His  Thr Val Lys 
    1370                 1375                 1380             


Glu His  Pro Gly Lys Gly Pro  Ser His Ser Ile Val  Pro Leu Ala 
    1385                 1390                 1395             


Val Ala  Leu Thr Leu Val Val  Ile Leu Ala Ile Ile  Thr Leu Ser 
    1400                 1405                 1410             


Phe Tyr  Ile Tyr Lys Gln Asn  Lys Gly Phe Phe Arg  Arg Leu Ala 
    1415                 1420                 1425             


Gly Val  Gly Asn Ser Tyr Tyr  Pro Thr Thr Asn Phe  Ser Thr Ile 
    1430                 1435                 1440             


His Leu  Glu Glu Asn Ile Leu  Ile Ser Asp Leu Glu  Lys Asn Asp 
    1445                 1450                 1455             


<210>  14
<211>  1464
<212>  PRT
<213>  Pongo abelii

<400>  14

Met Leu Leu Ser Pro Ser Leu Leu Leu Pro Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Pro Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu 
            20                  25                  30          


Arg Leu Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu 
        35                  40                  45              


Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu 
    50                  55                  60                  


Asn Cys Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn 
65                  70                  75                  80  


His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe 
                85                  90                  95      


Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu 
            100                 105                 110         


Val Ser Leu Arg Trp Arg Cys Asp Arg Lys Met Ile Thr Gly Pro Leu 
        115                 120                 125             


Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg 
    130                 135                 140                 


Lys Tyr Phe His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile 
145                 150                 155                 160 


Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Ala His 
                165                 170                 175     


Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His 
            180                 185                 190         


Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr 
        195                 200                 205             


Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro 
    210                 215                 220                 


Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn 
225                 230                 235                 240 


Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser 
                245                 250                 255     


Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Ala Leu Leu Ser Ile 
            260                 265                 270         


Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys 
        275                 280                 285             


Thr Val Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly 
    290                 295                 300                 


Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro 
305                 310                 315                 320 


Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser 
                325                 330                 335     


Ser Phe Ile Pro Ser Ala Trp Arg Ser Arg Asp Cys Ala Ser Thr Leu 
            340                 345                 350         


Pro Tyr Val Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val 
        355                 360                 365             


Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp 
    370                 375                 380                 


Asn Pro Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr 
385                 390                 395                 400 


Trp His Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile 
                405                 410                 415     


Asp Ile Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp His Thr Leu Glu Pro Gln Ile Phe Pro Asn Arg Ser Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu 
                485                 490                 495     


Glu Thr Leu Phe Tyr Val Cys Lys Lys Ala Gly His Val Leu Ser Asp 
            500                 505                 510         


Ala Glu Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys 
        515                 520                 525             


Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly 
    530                 535                 540                 


Tyr Tyr Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln 
545                 550                 555                 560 


Ala Phe Ile Thr Ser Leu Ile Gly Ser Val Val Lys Met Lys Asp Ser 
                565                 570                 575     


Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr 
            580                 585                 590         


Trp Lys Pro Ala Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp 
        595                 600                 605             


Asn Ala His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly 
    610                 615                 620                 


Arg His Pro Pro Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys 
625                 630                 635                 640 


Ala Met Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu 
                645                 650                 655     


Tyr Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser 
            660                 665                 670         


Glu Pro Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val 
        675                 680                 685             


Leu Met Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe 
    690                 695                 700                 


Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val 
705                 710                 715                 720 


Asn Glu Leu Leu Tyr Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe 
                725                 730                 735     


Trp Ile Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu 
            740                 745                 750         


Trp Ser Asp Arg Ile Pro Val Val Ser Ser Phe Leu Asp Asn Asn Tyr 
        755                 760                 765             


Phe Gly Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr 
    770                 775                 780                 


Leu Leu Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile 
785                 790                 795                 800 


Pro Arg Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val 
                805                 810                 815     


Pro Trp Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala 
            820                 825                 830         


Ser Glu Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp 
        835                 840                 845             


Leu Leu Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys 
    850                 855                 860                 


Ile Lys Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln 
865                 870                 875                 880 


Glu Glu Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val 
                885                 890                 895     


Ile Tyr Gln Asn Trp Asp Thr Gly Arg Glu Arg Pro Val Asn Asn Gln 
            900                 905                 910         


Ser Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser 
        915                 920                 925             


Glu Glu Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val 
    930                 935                 940                 


Leu Leu Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys 
945                 950                 955                 960 


Pro Lys Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile 
                965                 970                 975     


Pro Lys Asp Pro Asn Ser Trp Lys Asn Trp Met His Ala Gln His Phe 
            980                 985                 990         


Cys Ala Glu Glu Gly Gly Thr Leu  Val Ala Ile Glu Ser  Glu Val Glu 
        995                 1000                 1005             


Gln Ala  Phe Ile Thr Met Asn  Leu Phe Gly Gln Thr  Thr Asn Val 
    1010                 1015                 1020             


Trp Ile  Gly Leu Gln Asn Asp  Asp Tyr Glu Thr Trp  Leu Asn Gly 
    1025                 1030                 1035             


Lys Pro  Val Val Tyr Ser Asn  Trp Ser Pro Phe Asp  Ile Ile Asn 
    1040                 1045                 1050             


Ile Pro  Ser His Asn Thr Thr  Asp Val Gln Lys His  Ile Pro Leu 
    1055                 1060                 1065             


Cys Ala  Leu Leu Ser Ser Asn  Pro Asn Phe His Phe  Thr Gly Lys 
    1070                 1075                 1080             


Trp Tyr  Phe Glu Asp Cys Gly  Lys Glu Gly Tyr Gly  Phe Val Cys 
    1085                 1090                 1095             


Glu Lys  Met Gln Asp Thr Ser  Gly His Gly Val Asn  Thr Ser Asp 
    1100                 1105                 1110             


Met Tyr  Pro Met Pro Asn Thr  Leu Glu Tyr Gly Asn  Arg Thr Tyr 
    1115                 1120                 1125             


Lys Ile  Ile Asn Ala Asn Met  Thr Trp Tyr Ala Ala  Ile Lys Thr 
    1130                 1135                 1140             


Cys Leu  Met His Gly Thr Gln  Leu Val Ser Ile Thr  Asp Gln Tyr 
    1145                 1150                 1155             


His Gln  Ser Phe Leu Thr Val  Val Leu Asn Arg Leu  Gly Tyr Ala 
    1160                 1165                 1170             


His Trp  Ile Gly Leu Phe Thr  Thr Asp Asn Gly Leu  Asn Phe Asp 
    1175                 1180                 1185             


Trp Ser  Asp Gly Thr Lys Ser  Ser Phe Thr Phe Trp  Lys Asp Glu 
    1190                 1195                 1200             


Glu Ser  Ser Leu Leu Gly Asp  Cys Val Phe Ala Asp  Thr Asn Gly 
    1205                 1210                 1215             


Leu Trp  His Ser Thr Ala Cys  Glu Ser Phe Leu Gln  Gly Ala Ile 
    1220                 1225                 1230             


Cys His  Val Pro Pro Glu Thr  Arg Gln Ser Glu His  Pro Glu Leu 
    1235                 1240                 1245             


Cys Ser  Glu Thr Ser Ile Pro  Trp Ile Lys Phe Lys  Ser Asn Cys 
    1250                 1255                 1260             


Tyr Ser  Phe Ser Thr Val Leu  Asp Arg Met Ser Phe  Glu Ala Ala 
    1265                 1270                 1275             


His Glu  Phe Cys Lys Lys Glu  Gly Ser Asn Leu Leu  Thr Ile Lys 
    1280                 1285                 1290             


Asp Glu  Ala Glu Asn Ala Phe  Leu Leu Glu Glu Leu  Phe Ala Phe 
    1295                 1300                 1305             


Gly Ser  Ser Val Gln Met Val  Trp Leu Asn Ala Gln  Phe Asp Gly 
    1310                 1315                 1320             


Asn Asn  Glu Thr Ile Lys Trp  Phe Asp Gly Thr Pro  Thr Asp Gln 
    1325                 1330                 1335             


Ser Asn  Trp Gly Ile Arg Lys  Pro Asp Thr Asp Tyr  Phe Lys Pro 
    1340                 1345                 1350             


His His  Cys Val Ala Leu Arg  Ile Pro Glu Gly Leu  Gln Leu Ser 
    1355                 1360                 1365             


Leu Cys  Gln Glu Lys Lys Gly  Phe Ile Cys Lys Met  Glu Ala Asp 
    1370                 1375                 1380             


Ile Arg  Thr Ala Glu Glu Leu  Pro Glu Lys Gly Pro  Ser His Ser 
    1385                 1390                 1395             


Ile Ile  Pro Leu Ala Val Val  Leu Thr Leu Ile Val  Ile Val Ala 
    1400                 1405                 1410             


Ile Cys  Thr Leu Ser Phe Cys  Ile Tyr Lys His Asn  Gly Gly Phe 
    1415                 1420                 1425             


Phe Arg  Arg Leu Ala Gly Phe  Arg Asn Pro Tyr Tyr  Pro Ala Thr 
    1430                 1435                 1440             


Asn Phe  Ser Thr Val His Leu  Glu Glu Asn Ile Leu  Ile Ser Asp 
    1445                 1450                 1455             


Leu Glu  Lys Ser Asp Gln 
    1460                 


<210>  15
<211>  146
<212>  PRT
<213>  Sus scrofa

<400>  15

Met Lys Phe Leu Val Leu Ala Val Leu Leu Thr Val Gly Ala Ala Gln 
1               5                   10                  15      


Glu Gly Ile Ser Ser Arg Ala Leu Trp Gln Phe Arg Ser Met Ile Lys 
            20                  25                  30          


Cys Ala Ile Pro Gly Ser His Pro Leu Met Asp Phe Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Arg Cys Cys Glu Thr His Asp Asn Cys Tyr Arg Asp Ala Lys Asn Leu 
65                  70                  75                  80  


Asp Ser Cys Lys Phe Leu Val Asp Asn Pro Tyr Thr Glu Ser Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Asn Thr Glu Ile Thr Cys Asn Ser Lys Asn Asn Ala 
            100                 105                 110         


Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Ala Pro Tyr Asn Lys Glu His Lys Asn Leu Asp Thr Lys Lys 
    130                 135                 140                 


Tyr Cys 
145     


<210>  16
<211>  145
<212>  PRT
<213>  Bos taurus

<400>  16

Met Arg Leu Leu Val Leu Ala Ala Leu Leu Thr Val Gly Ala Gly Gln 
1               5                   10                  15      


Ala Gly Leu Asn Ser Arg Ala Leu Trp Gln Phe Asn Gly Met Ile Lys 
            20                  25                  30          


Cys Lys Ile Pro Ser Ser Glu Pro Leu Leu Asp Phe Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Asp Leu Asp 
    50                  55                  60                  


Arg Cys Cys Gln Thr His Asp Asn Cys Tyr Lys Gln Ala Lys Lys Leu 
65                  70                  75                  80  


Asp Ser Cys Lys Val Leu Val Asp Asn Pro Tyr Thr Asn Asn Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Asn Asn Glu Ile Thr Cys Ser Ser Glu Asn Asn Ala 
            100                 105                 110         


Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Val Pro Tyr Asn Lys Glu His Lys Asn Leu Asp Lys Lys Asn 
    130                 135                 140                 


Cys 
145 


<210>  17
<211>  146
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Lys Val Leu Leu Leu Leu Ala Val Val Ile Met Ala Phe Gly Ser 
1               5                   10                  15      


Ile Gln Val Gln Gly Ser Leu Leu Glu Phe Gly Gln Met Ile Leu Phe 
            20                  25                  30          


Lys Thr Gly Lys Arg Ala Asp Val Ser Tyr Gly Phe Tyr Gly Cys His 
        35                  40                  45              


Cys Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Trp Cys 
    50                  55                  60                  


Cys Val Thr His Asp Cys Cys Tyr Asn Arg Leu Glu Lys Arg Gly Cys 
65                  70                  75                  80  


Gly Thr Lys Phe Leu Thr Tyr Lys Phe Ser Tyr Arg Gly Gly Gln Ile 
                85                  90                  95      


Ser Cys Ser Thr Asn Gln Asp Ser Cys Arg Lys Gln Leu Cys Gln Cys 
            100                 105                 110         


Asp Lys Ala Ala Ala Glu Cys Phe Ala Arg Asn Lys Lys Ser Tyr Ser 
        115                 120                 125             


Leu Lys Tyr Gln Phe Tyr Pro Asn Lys Phe Cys Lys Gly Lys Thr Pro 
    130                 135                 140                 


Ser Cys 
145     


<210>  18
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Glu Ala Ala Leu Glu Ala Val Arg Ser Glu Leu Arg Glu Phe 
1               5                   10                  15      


Pro Ala Ala Ala Arg Glu Leu Cys Val Pro Leu Ala Val Pro Tyr Leu 
            20                  25                  30          


Asp Lys Pro Pro Thr Pro Leu His Phe Tyr Arg Asp Trp Val Cys Pro 
        35                  40                  45              


Asn Arg Pro Cys Ile Ile Arg Asn Ala Leu Gln His Trp Pro Ala Leu 
    50                  55                  60                  


Gln Lys Trp Ser Leu Pro Tyr Phe Arg Ala Thr Val Gly Ser Thr Glu 
65                  70                  75                  80  


Val Ser Val Ala Val Thr Pro Asp Gly Tyr Ala Asp Ala Val Arg Gly 
                85                  90                  95      


Asp Arg Phe Met Met Pro Ala Glu Arg Arg Leu Pro Leu Ser Phe Val 
            100                 105                 110         


Leu Asp Val Leu Glu Gly Arg Ala Gln His Pro Gly Val Leu Tyr Val 
        115                 120                 125             


Gln Lys Gln Cys Ser Asn Leu Pro Ser Glu Leu Pro Gln Leu Leu Pro 
    130                 135                 140                 


Asp Leu Glu Ser His Val Pro Trp Ala Ser Glu Ala Leu Gly Lys Met 
145                 150                 155                 160 


Pro Asp Ala Val Asn Phe Trp Leu Gly Glu Ala Ala Ala Val Thr Ser 
                165                 170                 175     


Leu His Lys Asp His Tyr Glu Asn Leu Tyr Cys Val Val Ser Gly Glu 
            180                 185                 190         


Lys His Phe Leu Phe His Pro Pro Ser Asp Arg Pro Phe Ile Pro Tyr 
        195                 200                 205             


Glu Leu Tyr Thr Pro Ala Thr Tyr Gln Leu Thr Glu Glu Gly Thr Phe 
    210                 215                 220                 


Lys Val Val Asp Glu Glu Ala Met Glu Lys Ala Glu Val Ser Arg Thr 
225                 230                 235                 240 


Cys Leu Leu Thr Val Arg Val Leu Gln Ala His Arg Leu Pro Ser Lys 
                245                 250                 255     


Asp Leu Val Thr Pro Ser Asp Cys Tyr Val Thr Leu Trp Leu Pro Thr 
            260                 265                 270         


Ala Cys Ser His Arg Leu Gln Thr Arg Thr Val Lys Asn Ser Ser Ser 
        275                 280                 285             


Pro Val Trp Asn Gln Ser Phe His Phe Arg Ile His Arg Gln Leu Lys 
    290                 295                 300                 


Asn Val Met Glu Leu Lys Val Phe Asp Gln Asp Leu Val Thr Gly Asp 
305                 310                 315                 320 


Asp Pro Val Leu Ser Val Leu Phe Asp Ala Gly Thr Leu Arg Ala Gly 
                325                 330                 335     


Glu Phe Arg Arg Glu Ser Phe Ser Leu Ser Pro Gln Gly Glu Gly Arg 
            340                 345                 350         


Leu Glu Val Glu Phe Arg Leu Gln Ser Leu Ala Asp Arg Gly Glu Trp 
        355                 360                 365             


Leu Val Ser Asn Gly Val Leu Val Ala Arg Glu Leu Ser Cys Leu His 
    370                 375                 380                 


Val Gln Leu Glu Glu Thr Gly Asp Gln Lys Ser Ser Glu His Arg Val 
385                 390                 395                 400 


Gln Leu Val Val Pro Gly Ser Cys Glu Gly Pro Gln Glu Ala Ser Val 
                405                 410                 415     


Gly Thr Gly Thr Phe Arg Phe His Cys Pro Ala Cys Trp Glu Gln Glu 
            420                 425                 430         


Leu Ser Ile Arg Leu Gln Asp Ala Pro Glu Glu Gln Leu Lys Ala Pro 
        435                 440                 445             


Leu Ser Ala Leu Pro Ser Gly Gln Val Val Arg Leu Val Phe Pro Thr 
    450                 455                 460                 


Ser Gln Glu Pro Leu Met Arg Val Glu Leu Lys Lys Glu Ala Gly Leu 
465                 470                 475                 480 


Arg Glu Leu Ala Val Arg Leu Gly Phe Gly Pro Cys Ala Glu Glu Gln 
                485                 490                 495     


Ala Phe Leu Ser Arg Arg Lys Gln Val Val Ala Ala Ala Leu Arg Gln 
            500                 505                 510         


Ala Leu Gln Leu Asp Gly Asp Leu Gln Glu Asp Glu Ile Pro Val Val 
        515                 520                 525             


Ala Ile Met Ala Thr Gly Gly Gly Ile Arg Ala Met Thr Ser Leu Tyr 
    530                 535                 540                 


Gly Gln Leu Ala Gly Leu Lys Glu Leu Gly Leu Leu Asp Cys Val Ser 
545                 550                 555                 560 


Tyr Ile Thr Gly Ala Ser Gly Ser Thr Trp Ala Leu Ala Asn Leu Tyr 
                565                 570                 575     


Glu Asp Pro Glu Trp Ser Gln Lys Asp Leu Ala Gly Pro Thr Glu Leu 
            580                 585                 590         


Leu Lys Thr Gln Val Thr Lys Asn Lys Leu Gly Val Leu Ala Pro Ser 
        595                 600                 605             


Gln Leu Gln Arg Tyr Arg Gln Glu Leu Ala Glu Arg Ala Arg Leu Gly 
    610                 615                 620                 


Tyr Pro Ser Cys Phe Thr Asn Leu Trp Ala Leu Ile Asn Glu Ala Leu 
625                 630                 635                 640 


Leu His Asp Glu Pro His Asp His Lys Leu Ser Asp Gln Arg Glu Ala 
                645                 650                 655     


Leu Ser His Gly Gln Asn Pro Leu Pro Ile Tyr Cys Ala Leu Asn Thr 
            660                 665                 670         


Lys Gly Gln Ser Leu Thr Thr Phe Glu Phe Gly Glu Trp Cys Glu Phe 
        675                 680                 685             


Ser Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala Phe Ile Pro Ser 
    690                 695                 700                 


Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Gln Leu Met Lys Arg Leu 
705                 710                 715                 720 


Pro Glu Ser Arg Ile Cys Phe Leu Glu Gly Ile Trp Ser Asn Leu Tyr 
                725                 730                 735     


Ala Ala Asn Leu Gln Asp Ser Leu Tyr Trp Ala Ser Glu Pro Ser Gln 
            740                 745                 750         


Phe Trp Asp Arg Trp Val Arg Asn Gln Ala Asn Leu Asp Lys Glu Gln 
        755                 760                 765             


Val Pro Leu Leu Lys Ile Glu Glu Pro Pro Ser Thr Ala Gly Arg Ile 
    770                 775                 780                 


Ala Glu Phe Phe Thr Asp Leu Leu Thr Trp Arg Pro Leu Ala Gln Ala 
785                 790                 795                 800 


Thr His Asn Phe Leu Arg Gly Leu His Phe His Lys Asp Tyr Phe Gln 
                805                 810                 815     


His Pro His Phe Ser Thr Trp Lys Ala Thr Thr Leu Asp Gly Leu Pro 
            820                 825                 830         


Asn Gln Leu Thr Pro Ser Glu Pro His Leu Cys Leu Leu Asp Val Gly 
        835                 840                 845             


Tyr Leu Ile Asn Thr Ser Cys Leu Pro Leu Leu Gln Pro Thr Arg Asp 
    850                 855                 860                 


Val Asp Leu Ile Leu Ser Leu Asp Tyr Asn Leu His Gly Ala Phe Gln 
865                 870                 875                 880 


Gln Leu Gln Leu Leu Gly Arg Phe Cys Gln Glu Gln Gly Ile Pro Phe 
                885                 890                 895     


Pro Pro Ile Ser Pro Ser Pro Glu Glu Gln Leu Gln Pro Arg Glu Cys 
            900                 905                 910         


His Thr Phe Ser Asp Pro Thr Cys Pro Gly Ala Pro Ala Val Leu His 
        915                 920                 925             


Phe Pro Leu Val Ser Asp Ser Phe Arg Glu Tyr Ser Ala Pro Gly Val 
    930                 935                 940                 


Arg Arg Thr Pro Glu Glu Ala Ala Ala Gly Glu Val Asn Leu Ser Ser 
945                 950                 955                 960 


Ser Asp Ser Pro Tyr His Tyr Thr Lys Val Thr Tyr Ser Gln Glu Asp 
                965                 970                 975     


Val Asp Lys Leu Leu His Leu Thr His Tyr Asn Val Cys Asn Asn Gln 
            980                 985                 990         


Glu Gln Leu Leu Glu Ala Leu Arg  Gln Ala Val Gln Arg  Arg Arg Gln 
        995                 1000                 1005             


Arg Arg  Pro His 
    1010         


<210>  19
<211>  119
<212>  PRT
<213>  Sus scrofa

<400>  19

Ala Leu Trp Gln Phe Arg Ser Met Ile Lys Cys Ala Ile Pro Gly Ser 
1               5                   10                  15      


His Pro Leu Met Asp Phe Asn Asn Tyr Gly Cys Tyr Cys Gly Leu Gly 
            20                  25                  30          


Gly Ser Gly Thr Pro Val Asp Glu Leu Asp Arg Cys Cys Glu Thr His 
        35                  40                  45              


Asp Asn Cys Tyr Arg Asp Ala Lys Asn Leu Ser Gly Cys Tyr Pro Tyr 
    50                  55                  60                  


Thr Glu Ser Tyr Ser Tyr Ser Cys Ser Asn Thr Glu Ile Thr Cys Asn 
65                  70                  75                  80  


Ser Lys Asn Asn Ala Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn 
                85                  90                  95      


Ala Ala Ile Cys Phe Ser Lys Ala Pro Tyr Asn Lys Glu His Lys Asn 
            100                 105                 110         


Leu Asp Thr Lys Lys Tyr Cys 
        115                 


<210>  20
<211>  119
<212>  PRT
<213>  Sus scrofa

<400>  20

Ala Leu Trp Gln Phe Arg Ser Met Ile Lys Cys Ala Ile Pro Gly Ser 
1               5                   10                  15      


His Pro Leu Met Asp Phe Asn Asn Tyr Gly Cys Tyr Cys Gly Leu Gly 
            20                  25                  30          


Gly Ser Gly Thr Pro Val Asp Glu Leu Asp Arg Cys Cys Glu Thr His 
        35                  40                  45              


Asp Asn Cys Tyr Arg Asp Ala Lys Asn Leu Ser Gly Cys Tyr Pro Tyr 
    50                  55                  60                  


Thr Glu Ser Tyr Ser Tyr Ser Cys Ser Asn Thr Glu Ile Thr Cys Asn 
65                  70                  75                  80  


Ser Lys Asn Asn Ala Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn 
                85                  90                  95      


Ala Ala Ile Cys Phe Ser Lys Ala Pro Tyr Asn Lys Glu His Lys Asn 
            100                 105                 110         


Leu Asp Thr Lys Lys Tyr Cys 
        115                 


<210>  21
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Ser Ser Glu Val Ser Ile Ile Pro Gly Leu Gln Lys Glu Glu 
1               5                   10                  15      


Lys Ala Ala Val Glu Arg Arg Arg Leu His Val Leu Lys Ala Leu Lys 
            20                  25                  30          


Lys Leu Arg Ile Glu Ala Asp Glu Ala Pro Val Val Ala Val Leu Gly 
        35                  40                  45              


Ser Gly Gly Gly Leu Arg Ala His Ile Ala Cys Leu Gly Val Leu Ser 
    50                  55                  60                  


Glu Met Lys Glu Gln Gly Leu Leu Asp Ala Val Thr Tyr Leu Ala Gly 
65                  70                  75                  80  


Val Ser Gly Ser Thr Trp Ala Ile Ser Ser Leu Tyr Thr Asn Asp Gly 
                85                  90                  95      


Asp Met Glu Ala Leu Glu Ala Asp Leu Lys His Arg Phe Thr Arg Gln 
            100                 105                 110         


Glu Trp Asp Leu Ala Lys Ser Leu Gln Lys Thr Ile Gln Ala Ala Arg 
        115                 120                 125             


Ser Glu Asn Tyr Ser Leu Thr Asp Phe Trp Ala Tyr Met Val Ile Ser 
    130                 135                 140                 


Lys Gln Thr Arg Glu Leu Pro Glu Ser His Leu Ser Asn Met Lys Lys 
145                 150                 155                 160 


Pro Val Glu Glu Gly Thr Leu Pro Tyr Pro Ile Phe Ala Ala Ile Asp 
                165                 170                 175     


Asn Asp Leu Gln Pro Ser Trp Gln Glu Ala Arg Ala Pro Glu Thr Trp 
            180                 185                 190         


Phe Glu Phe Thr Pro His His Ala Gly Phe Pro Ala Leu Gly Ala Phe 
        195                 200                 205             


Val Ser Ile Thr His Phe Gly Ser Lys Phe Lys Lys Gly Arg Leu Val 
    210                 215                 220                 


Arg Thr His Pro Glu Arg Asp Leu Thr Phe Leu Arg Gly Leu Trp Gly 
225                 230                 235                 240 


Ser Ala Leu Gly Asn Thr Glu Val Ile Arg Glu Tyr Ile Phe Asp Gln 
                245                 250                 255     


Leu Arg Asn Leu Thr Leu Lys Gly Leu Trp Arg Arg Ala Val Ala Asn 
            260                 265                 270         


Ala Lys Ser Ile Gly His Leu Ile Phe Ala Arg Leu Leu Arg Leu Gln 
        275                 280                 285             


Glu Ser Ser Gln Gly Glu His Pro Pro Pro Glu Asp Glu Gly Gly Glu 
    290                 295                 300                 


Pro Glu His Thr Trp Leu Thr Glu Met Leu Glu Asn Trp Thr Arg Thr 
305                 310                 315                 320 


Ser Leu Glu Lys Gln Glu Gln Pro His Glu Asp Pro Glu Arg Lys Gly 
                325                 330                 335     


Ser Leu Ser Asn Leu Met Asp Phe Val Lys Lys Thr Gly Ile Cys Ala 
            340                 345                 350         


Ser Lys Trp Glu Trp Gly Thr Thr His Asn Phe Leu Tyr Lys His Gly 
        355                 360                 365             


Gly Ile Arg Asp Lys Ile Met Ser Ser Arg Lys His Leu His Leu Val 
    370                 375                 380                 


Asp Ala Gly Leu Ala Ile Asn Thr Pro Phe Pro Leu Val Leu Pro Pro 
385                 390                 395                 400 


Thr Arg Glu Val His Leu Ile Leu Ser Phe Asp Phe Ser Ala Gly Asp 
                405                 410                 415     


Pro Phe Glu Thr Ile Arg Ala Thr Thr Asp Tyr Cys Arg Arg His Lys 
            420                 425                 430         


Ile Pro Phe Pro Gln Val Glu Glu Ala Glu Leu Asp Leu Trp Ser Lys 
        435                 440                 445             


Ala Pro Ala Ser Cys Tyr Ile Leu Lys Gly Glu Thr Gly Pro Val Val 
    450                 455                 460                 


Met His Phe Pro Leu Phe Asn Ile Asp Ala Cys Gly Gly Asp Ile Glu 
465                 470                 475                 480 


Ala Trp Ser Asp Thr Tyr Asp Thr Phe Lys Leu Ala Asp Thr Tyr Thr 
                485                 490                 495     


Leu Asp Val Val Val Leu Leu Leu Ala Leu Ala Lys Lys Asn Val Arg 
            500                 505                 510         


Glu Asn Lys Lys Lys Ile Leu Arg Glu Leu Met Asn Val Ala Gly Leu 
        515                 520                 525             


Tyr Tyr Pro Lys Asp Ser Ala Arg Ser Cys Cys Leu Ala 
    530                 535                 540     


<210>  22
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  23
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  23

Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr Thr Gly Lys Glu 
1               5                   10                  15      


Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys Gly Val Gly Gly 
            20                  25                  30          


Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys Val Thr His Asp 
        35                  40                  45              


Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly Thr Lys Phe Leu 
    50                  55                  60                  


Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr Cys Ala Lys Gln 
65                  70                  75                  80  


Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys Ala Ala Ala Thr 
                85                  90                  95      


Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys Tyr Gln Tyr Tyr 
            100                 105                 110         


Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
        115                 120                 


<210>  24
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  24

Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr Thr Gly Lys Glu 
1               5                   10                  15      


Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys Gly Val Gly Gly 
            20                  25                  30          


Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys Val Thr His Asp 
        35                  40                  45              


Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly Thr Lys Phe Leu 
    50                  55                  60                  


Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr Cys Ala Lys Gln 
65                  70                  75                  80  


Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys Ala Ala Ala Thr 
                85                  90                  95      


Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys Tyr Gln Tyr Tyr 
            100                 105                 110         


Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
        115                 120                 


<210>  25
<211>  146
<212>  PRT
<213>  Mus musculus

<400>  25

Met Lys Val Leu Leu Leu Leu Ala Ala Ser Ile Met Ala Phe Gly Ser 
1               5                   10                  15      


Ile Gln Val Gln Gly Asn Ile Ala Gln Phe Gly Glu Met Ile Arg Leu 
            20                  25                  30          


Lys Thr Gly Lys Arg Ala Glu Leu Ser Tyr Ala Phe Tyr Gly Cys His 
        35                  40                  45              


Cys Gly Leu Gly Gly Lys Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys 
    50                  55                  60                  


Cys Val Thr His Asp Cys Cys Tyr Lys Ser Leu Glu Lys Ser Gly Cys 
65                  70                  75                  80  


Gly Thr Lys Leu Leu Lys Tyr Lys Tyr Ser His Gln Gly Gly Gln Ile 
                85                  90                  95      


Thr Cys Ser Ala Asn Gln Asn Ser Cys Gln Lys Arg Leu Cys Gln Cys 
            100                 105                 110         


Asp Lys Ala Ala Ala Glu Cys Phe Ala Arg Asn Lys Lys Thr Tyr Ser 
        115                 120                 125             


Leu Lys Tyr Gln Phe Tyr Pro Asn Met Phe Cys Lys Gly Lys Lys Pro 
    130                 135                 140                 


Lys Cys 
145     


<210>  26
<211>  501
<212>  PRT
<213>  Bos taurus

<400>  26

Met Gly Val Leu Val Val Leu Leu Gly Val Leu Ser Phe Leu Gly Arg 
1               5                   10                  15      


Thr Leu Gly Gly Ser Pro Ala Leu His Trp Asp Ser Thr Ser Cys His 
            20                  25                  30          


Leu Ala Arg Pro Ile Pro Gly Arg Pro Leu Arg Ser Leu Ser Phe Leu 
        35                  40                  45              


Gly Lys Asp Ala Gln Gly Leu Ala Leu Phe His Ala His Trp Asp Gly 
    50                  55                  60                  


His Gly Arg Leu Gln Val Cys Ser Arg Gln Asp Glu Pro Glu Leu Thr 
65                  70                  75                  80  


Ala Ala Tyr Gly Ala Leu Cys Ala Gly Glu Ile Thr Arg Gly Ser Phe 
                85                  90                  95      


Ile His Thr Pro Gly Pro Glu Leu Gln Arg Ala Leu Ala Thr Leu Gln 
            100                 105                 110         


Ser Gln Trp Glu Ala Cys Arg Gly Pro Ala Glu Ser Pro Ala Gly Thr 
        115                 120                 125             


Arg Glu Lys Arg Ala Ala Gly Gln Asn Gly Val Pro Gly Ile Gly Arg 
    130                 135                 140                 


Gln Trp Val Lys Arg Gly Trp Thr Val Pro Gly Thr Leu Trp Cys Gly 
145                 150                 155                 160 


Val Gly Asp Ser Ala Gly Asn Ser Ser Glu Leu Gly Val Phe Gln Gly 
                165                 170                 175     


Pro Asp Leu Cys Cys Arg Glu His Asp Arg Cys Pro His Asn Val Ser 
            180                 185                 190         


Pro Phe Gln Tyr Asn Tyr Gly Ile Arg Asn Tyr Arg Phe His Thr Ile 
        195                 200                 205             


Ser His Cys Asn Cys Asp Ala Arg Phe Gln Gln Cys Leu Gln Asp Gln 
    210                 215                 220                 


Arg Asp Ser Val Ser Asp Ile Met Gly Val Ala Phe Phe Asn Val Leu 
225                 230                 235                 240 


Ala Ile Pro Cys Phe Val Leu Glu Glu Gln Glu Ala Cys Val Glu Trp 
                245                 250                 255     


Tyr Trp Trp Gly Gly Cys Arg Arg Tyr Gly Ser Val Pro Phe Ala Arg 
            260                 265                 270         


Leu Gln Pro Arg Thr Phe Tyr Asn Ala Ser Trp Ser Ser Pro Ala Thr 
        275                 280                 285             


Ser Leu Thr Pro Ser Pro Gln Asn Pro Ala Leu Ser Arg Pro Gln Pro 
    290                 295                 300                 


Met Gln His Pro Gln Gln Trp Pro Ser Glu Trp Lys Glu Ser Lys Ser 
305                 310                 315                 320 


Pro Ser Lys Thr Asn Ala Thr Ala Leu Gln Ala Pro Val Ala Ser Pro 
                325                 330                 335     


Gly Ser Asp Arg Ala Ser Thr Val Gln Leu Glu Val Thr His Pro Gly 
            340                 345                 350         


Phe Gln Gly Thr Thr Gly Gly Arg Lys Pro Pro Gly Ala His Arg Ala 
        355                 360                 365             


Cys Arg Ser Phe Arg His Leu Asp Gln Cys Glu His Gln Ile Gly Pro 
    370                 375                 380                 


Gln Glu Thr Lys Phe Gln Leu Phe Asn Ser Ala His Glu Pro Leu Phe 
385                 390                 395                 400 


His Cys Asn Cys Thr Arg Arg Leu Ala Arg Phe Leu Arg Leu His Gly 
                405                 410                 415     


Pro Pro Val Gly Ala Ser Met Leu Trp Glu Leu Pro Gly Met Thr Cys 
            420                 425                 430         


Phe Lys Leu Ala Pro Pro Leu Asp Cys Ala Glu Gly Lys Gly Cys Pro 
        435                 440                 445             


Arg Asp Pro Arg Ala Phe Lys Val Ser Ala Arg His Leu Leu Arg Leu 
    450                 455                 460                 


Gln Gln Arg Arg Leu Gln Leu Gln Gly Thr Gly Thr Asp Asn Gly Gln 
465                 470                 475                 480 


Val Trp Pro Ser Glu Asp Gln Gly Ala Pro Ile Ser Phe Tyr Asn Arg 
                485                 490                 495     


Cys Leu Gln Leu Thr 
            500     


<210>  27
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Val Gln Ala Gly Leu Phe Gly Met Leu Gly Phe Leu Gly Val 
1               5                   10                  15      


Ala Leu Gly Gly Ser Pro Ala Leu Arg Trp Tyr Arg Thr Ser Cys His 
            20                  25                  30          


Leu Thr Lys Ala Val Pro Gly Asn Pro Leu Gly Tyr Leu Ser Phe Leu 
        35                  40                  45              


Ala Lys Asp Ala Gln Gly Leu Ala Leu Ile His Ala Arg Trp Asp Ala 
    50                  55                  60                  


His Arg Arg Leu Gln Ala Cys Ser Trp Glu Asp Glu Pro Glu Leu Thr 
65                  70                  75                  80  


Ala Ala Tyr Gly Ala Leu Cys Ala His Glu Thr Ala Trp Gly Ser Phe 
                85                  90                  95      


Ile His Thr Pro Gly Pro Glu Leu Gln Arg Ala Leu Ala Thr Leu Gln 
            100                 105                 110         


Ser Gln Trp Glu Ala Cys Arg Ala Leu Glu Glu Ser Pro Ala Gly Ala 
        115                 120                 125             


Arg Lys Lys Arg Ala Ala Gly Gln Ser Gly Val Pro Gly Gly Gly His 
    130                 135                 140                 


Gln Arg Glu Lys Arg Gly Trp Thr Met Pro Gly Thr Leu Trp Cys Gly 
145                 150                 155                 160 


Val Gly Asp Ser Ala Gly Asn Ser Ser Glu Leu Gly Val Phe Gln Gly 
                165                 170                 175     


Pro Asp Leu Cys Cys Arg Glu His Asp Arg Cys Pro Gln Asn Ile Ser 
            180                 185                 190         


Pro Leu Gln Tyr Asn Tyr Gly Ile Arg Asn Tyr Arg Phe His Thr Ile 
        195                 200                 205             


Ser His Cys Asp Cys Asp Thr Arg Phe Gln Gln Cys Leu Gln Asn Gln 
    210                 215                 220                 


His Asp Ser Ile Ser Asp Ile Val Gly Val Ala Phe Phe Asn Val Leu 
225                 230                 235                 240 


Glu Ile Pro Cys Phe Val Leu Glu Glu Gln Glu Ala Cys Val Ala Trp 
                245                 250                 255     


Tyr Trp Trp Gly Gly Cys Arg Met Tyr Gly Thr Val Pro Leu Ala Arg 
            260                 265                 270         


Leu Gln Pro Arg Thr Phe Tyr Asn Ala Ser Trp Ser Ser Arg Ala Thr 
        275                 280                 285             


Ser Pro Thr Pro Ser Ser Arg Ser Pro Ala Pro Pro Lys Pro Arg Gln 
    290                 295                 300                 


Lys Gln His Leu Arg Lys Gly Pro Pro His Gln Lys Gly Ser Lys Arg 
305                 310                 315                 320 


Pro Ser Lys Ala Asn Thr Thr Ala Leu Gln Asp Pro Met Val Ser Pro 
                325                 330                 335     


Arg Leu Asp Val Ala Pro Thr Gly Leu Gln Gly Pro Gln Gly Gly Leu 
            340                 345                 350         


Lys Pro Gln Gly Ala Arg Trp Val Cys Arg Ser Phe Arg Arg His Leu 
        355                 360                 365             


Asp Gln Cys Glu His Gln Ile Gly Pro Arg Glu Ile Glu Phe Gln Leu 
    370                 375                 380                 


Leu Asn Ser Ala Gln Glu Pro Leu Phe His Cys Asn Cys Thr Arg Arg 
385                 390                 395                 400 


Leu Ala Arg Phe Leu Arg Leu His Ser Pro Pro Glu Val Thr Asn Met 
                405                 410                 415     


Leu Trp Glu Leu Leu Gly Thr Thr Cys Phe Lys Leu Ala Pro Pro Leu 
            420                 425                 430         


Asp Cys Val Glu Gly Lys Asn Cys Ser Arg Asp Pro Arg Ala Ile Arg 
        435                 440                 445             


Val Ser Ala Arg His Leu Arg Arg Leu Gln Gln Arg Arg His Gln Leu 
    450                 455                 460                 


Gln Asp Lys Gly Thr Asp Glu Arg Gln Pro Trp Pro Ser Glu Pro Leu 
465                 470                 475                 480 


Arg Gly Pro Met Ser Phe Tyr Asn Gln Cys Leu Gln Leu Thr Gln Ala 
                485                 490                 495     


Ala Arg Arg Pro Asp Arg Gln Gln Lys Ser Trp Ser Gln 
            500                 505                 


<210>  28
<211>  68
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

His Leu Leu Asp Phe Arg Lys Met Ile Arg Tyr Thr Thr Gly Lys Glu 
1               5                   10                  15      


Ala Thr Thr Ser Tyr Gly Ala Tyr Gly Cys His Cys Gly Val Gly Gly 
            20                  25                  30          


Arg Gly Ala Pro Lys Xaa Ala Lys Phe Leu Ser Tyr Lys Phe Ser Met 
        35                  40                  45              


Lys Lys Ala Ala Ala Ala Cys Phe Lys Tyr Gln Phe Tyr Pro Asn Asn 
    50                  55                  60                  


Arg Cys Xaa Gly 
65              


<210>  29
<211>  151
<212>  PRT
<213>  Mus musculus

<400>  29

Met Leu Leu Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Pro Gly Phe 
1               5                   10                  15      


Ser Glu Ala Thr Arg Arg Ser His Val Tyr Lys Arg Gly Leu Leu Glu 
            20                  25                  30          


Leu Ala Gly Thr Leu Asp Cys Val Gly Pro Arg Ser Pro Met Ala Tyr 
        35                  40                  45              


Met Asn Tyr Gly Cys Tyr Cys Gly Leu Gly Gly His Gly Glu Pro Arg 
    50                  55                  60                  


Asp Ala Ile Asp Trp Cys Cys Tyr His His Asp Cys Cys Tyr Ser Arg 
65                  70                  75                  80  


Ala Gln Asp Ala Gly Cys Ser Pro Lys Leu Asp Arg Tyr Pro Trp Lys 
                85                  90                  95      


Cys Met Asp His His Ile Leu Cys Gly Pro Ala Glu Asn Lys Cys Gln 
            100                 105                 110         


Glu Leu Leu Cys Arg Cys Asp Glu Glu Leu Ala Tyr Cys Leu Ala Gly 
        115                 120                 125             


Thr Glu Tyr His Leu Lys Tyr Leu Phe Phe Pro Ser Ile Leu Cys Glu 
    130                 135                 140                 


Lys Asp Ser Pro Lys Cys Asn 
145                 150     


<210>  30
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15      


Ala Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30          


Thr Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys 
    50                  55                  60                  


Trp Ala His Asp His Cys Tyr Gly Arg Leu Glu Glu Lys Gly Cys Asn 
65                  70                  75                  80  


Ile Arg Thr Gln Ser Tyr Lys Tyr Arg Phe Ala Trp Gly Val Val Thr 
                85                  90                  95      


Cys Glu Pro Gly Pro Phe Cys His Val Asn Leu Cys Ala Cys Asp Arg 
            100                 105                 110         


Lys Leu Val Tyr Cys Leu Lys Arg Asn Leu Arg Ser Tyr Asn Pro Gln 
        115                 120                 125             


Tyr Gln Tyr Phe Pro Asn Ile Leu Cys Ser 
    130                 135             


<210>  31
<211>  146
<212>  PRT
<213>  Canis lupus

<400>  31

Met Lys Phe Leu Val Leu Ala Ala Leu Leu Thr Val Ala Ala Ala Glu 
1               5                   10                  15      


Gly Gly Ile Ser Pro Arg Ala Val Trp Gln Phe Arg Asn Met Ile Lys 
            20                  25                  30          


Cys Thr Ile Pro Glu Ser Asp Pro Leu Lys Asp Tyr Asn Asp Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Lys Cys Cys Gln Thr His Asp His Cys Tyr Ser Glu Ala Lys Lys Leu 
65                  70                  75                  80  


Asp Ser Cys Lys Phe Leu Leu Asp Asn Pro Tyr Thr Lys Ile Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Gly Ser Glu Ile Thr Cys Ser Ser Lys Asn Lys Asp 
            100                 105                 110         


Cys Gln Ala Phe Ile Cys Asn Cys Asp Arg Ser Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Ala Pro Tyr Asn Lys Glu His Lys Asn Leu Asp Thr Lys Lys 
    130                 135                 140                 


Tyr Cys 
145     


<210>  32
<211>  146
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Met Lys Leu Leu Leu Leu Ala Ala Leu Leu Thr Ala Gly Val Thr Ala 
1               5                   10                  15      


His Ser Ile Ser Thr Arg Ala Val Trp Gln Phe Arg Asn Met Ile Lys 
            20                  25                  30          


Cys Thr Ile Pro Gly Ser Asp Pro Leu Arg Glu Tyr Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Asp Leu Asp 
    50                  55                  60                  


Arg Cys Cys Gln Thr His Asp His Cys Tyr Asn Gln Ala Lys Lys Leu 
65                  70                  75                  80  


Glu Ser Cys Lys Phe Leu Ile Asp Asn Pro Tyr Thr Asn Thr Tyr Ser 
                85                  90                  95      


Tyr Lys Cys Ser Gly Asn Val Ile Thr Cys Ser Asp Lys Asn Asn Asp 
            100                 105                 110         


Cys Glu Ser Phe Ile Cys Asn Cys Asp Arg Gln Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Val Pro Tyr Asn Lys Glu Tyr Lys Asp Leu Asp Thr Lys Lys 
    130                 135                 140                 


His Cys 
145     


<210>  33
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Lys Leu Leu Val Leu Ala Val Leu Leu Thr Val Ala Ala Ala Asp 
1               5                   10                  15      


Ser Gly Ile Ser Pro Arg Ala Val Trp Gln Phe Arg Lys Met Ile Lys 
            20                  25                  30          


Cys Val Ile Pro Gly Ser Asp Pro Phe Leu Glu Tyr Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Lys Cys Cys Gln Thr His Asp Asn Cys Tyr Asp Gln Ala Lys Lys Leu 
65                  70                  75                  80  


Asp Ser Cys Lys Phe Leu Leu Asp Asn Pro Tyr Thr His Thr Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Gly Ser Ala Ile Thr Cys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Ala Pro Tyr Asn Lys Ala His Lys Asn Leu Asp Thr Lys Lys 
    130                 135                 140                 


Tyr Cys Gln Ser 
145             


<210>  34
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Ser Leu Ser Pro Gly Gly Pro Thr Gly His Pro Tyr Gln Gly 
1               5                   10                  15      


Glu Ala Ser Thr Cys Trp Gln Leu Thr Val Arg Val Leu Glu Ala Arg 
            20                  25                  30          


Asn Leu Arg Trp Ala Asp Leu Leu Ser Glu Ala Asp Pro Tyr Val Ile 
        35                  40                  45              


Leu Gln Leu Ser Thr Ala Pro Gly Met Lys Phe Lys Thr Lys Thr Leu 
    50                  55                  60                  


Thr Asp Thr Ser His Pro Val Trp Asn Glu Ala Phe Arg Phe Leu Ile 
65                  70                  75                  80  


Gln Ser Gln Val Lys Asn Val Leu Glu Leu Ser Ile Tyr Asp Glu Asp 
                85                  90                  95      


Ser Val Thr Glu Asp Asp Ile Cys Phe Lys Val Leu Tyr Asp Ile Ser 
            100                 105                 110         


Glu Val Leu Pro Gly Lys Leu Leu Arg Lys Thr Phe Ser Gln Ser Pro 
        115                 120                 125             


Gln Gly Glu Glu Glu Leu Asp Val Glu Phe Leu Met Glu Glu Thr Ser 
    130                 135                 140                 


Asp Arg Pro Glu Asn Leu Ile Thr Asn Lys Val Ile Val Ala Arg Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Asp Val His Leu Asp Ser Thr Gly Ser Thr Ala Val 
                165                 170                 175     


Val Ala Asp Gln Asp Lys Leu Glu Leu Glu Leu Val Leu Lys Gly Ser 
            180                 185                 190         


Tyr Glu Asp Thr Gln Thr Ser Phe Leu Gly Thr Ala Ser Ala Phe Arg 
        195                 200                 205             


Phe His Tyr Met Ala Ala Leu Glu Thr Glu Leu Ser Gly Arg Leu Arg 
    210                 215                 220                 


Ser Ser Arg Ser Asn Gly Trp Asn Gly Asp Asn Ser Ala Gly Tyr Leu 
225                 230                 235                 240 


Thr Val Pro Leu Arg Pro Leu Thr Ile Gly Lys Glu Val Thr Met Asp 
                245                 250                 255     


Val Pro Ala Pro Asn Ala Pro Gly Val Arg Leu Gln Leu Lys Ala Glu 
            260                 265                 270         


Gly Cys Pro Glu Glu Leu Ala Val His Leu Gly Phe Asn Leu Cys Ala 
        275                 280                 285             


Glu Glu Gln Ala Phe Leu Ser Arg Arg Lys Gln Val Val Ala Lys Ala 
    290                 295                 300                 


Leu Lys Gln Ala Leu Gln Leu Asp Arg Asp Leu Gln Glu Asp Glu Val 
305                 310                 315                 320 


Pro Val Val Gly Ile Met Ala Thr Gly Gly Gly Ala Arg Ala Met Thr 
                325                 330                 335     


Ser Leu Tyr Gly His Leu Leu Ala Leu Gln Lys Leu Gly Leu Leu Asp 
            340                 345                 350         


Cys Val Thr Tyr Phe Ser Gly Ile Ser Gly Ser Thr Trp Thr Met Ala 
        355                 360                 365             


His Leu Tyr Gly Asp Pro Glu Trp Ser Gln Arg Asp Leu Glu Gly Pro 
    370                 375                 380                 


Ile Arg Tyr Ala Arg Glu His Leu Ala Lys Ser Lys Leu Glu Val Phe 
385                 390                 395                 400 


Ser Pro Glu Arg Leu Ala Ser Tyr Arg Arg Glu Leu Glu Leu Arg Ala 
                405                 410                 415     


Glu Gln Gly His Pro Thr Thr Phe Val Asp Leu Trp Ala Leu Val Leu 
            420                 425                 430         


Glu Ser Met Leu His Gly Gln Val Met Asp Gln Lys Leu Ser Gly Gln 
        435                 440                 445             


Arg Ala Ala Leu Glu Arg Gly Gln Asn Pro Leu Pro Leu Tyr Leu Ser 
    450                 455                 460                 


Leu Asn Val Lys Glu Asn Asn Leu Glu Thr Leu Asp Phe Lys Glu Trp 
465                 470                 475                 480 


Val Glu Phe Ser Pro Tyr Glu Val Gly Phe Leu Lys Tyr Gly Ala Phe 
                485                 490                 495     


Val Pro Pro Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Arg Leu Met 
            500                 505                 510         


Arg Arg Ile Pro Glu Pro Arg Ile Cys Phe Leu Glu Ala Ile Trp Ser 
        515                 520                 525             


Asn Ile Phe Ser Leu Asn Leu Leu Asp Ala Trp Tyr Asp Leu Thr Ser 
    530                 535                 540                 


Ser Gly Glu Ser Trp Lys Gln His Ile Lys Asp Lys Thr Arg Ser Leu 
545                 550                 555                 560 


Glu Lys Glu Pro Leu Thr Thr Ser Gly Thr Ser Ser Arg Leu Glu Ala 
                565                 570                 575     


Ser Trp Leu Gln Pro Gly Thr Ala Leu Ala Gln Ala Phe Lys Gly Phe 
            580                 585                 590         


Leu Thr Gly Arg Pro Leu His Gln Arg Ser Pro Asn Phe Leu Gln Gly 
        595                 600                 605             


Leu Gln Leu His Gln Asp Tyr Cys Ser His Lys Asp Phe Ser Thr Trp 
    610                 615                 620                 


Ala Asp Tyr Gln Leu Asp Ser Met Pro Ser Gln Leu Thr Pro Lys Glu 
625                 630                 635                 640 


Pro Arg Leu Cys Leu Val Asp Ala Ala Tyr Phe Ile Asn Thr Ser Ser 
                645                 650                 655     


Pro Ser Met Phe Arg Pro Gly Arg Arg Leu Asp Leu Ile Leu Ser Phe 
            660                 665                 670         


Asp Tyr Ser Leu Ser Ala Pro Phe Glu Ala Leu Gln Gln Thr Glu Leu 
        675                 680                 685             


Tyr Cys Arg Ala Arg Gly Leu Pro Phe Pro Arg Val Glu Pro Ser Pro 
    690                 695                 700                 


Gln Asp Gln His Gln Pro Arg Glu Cys His Leu Phe Ser Asp Pro Ala 
705                 710                 715                 720 


Cys Pro Glu Ala Pro Ile Leu Leu His Phe Pro Leu Val Asn Ala Ser 
                725                 730                 735     


Phe Lys Asp His Ser Ala Pro Gly Val Gln Arg Ser Pro Ala Glu Leu 
            740                 745                 750         


Gln Gly Gly Gln Val Asp Leu Thr Gly Ala Thr Cys Pro Tyr Thr Leu 
        755                 760                 765             


Ser Asn Met Thr Tyr Lys Glu Glu Asp Phe Glu Arg Leu Leu Arg Leu 
    770                 775                 780                 


Ser Asp Tyr Asn Val Gln Thr Ser Gln Gly Ala Ile Leu Gln Ala Leu 
785                 790                 795                 800 


Arg Thr Ala Leu Lys His Arg Thr Leu Glu Ala Arg Pro Pro Arg Ala 
                805                 810                 815     


Gln Thr 
        


<210>  35
<211>  855
<212>  PRT
<213>  Mus musculus

<400>  35

Met Pro Trp Thr Leu Gln Pro Lys Trp Leu Ala Gly Lys Gly Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ala Ile Leu Leu Arg Lys Thr Glu Lys Ser Glu Pro Gln 
            20                  25                  30          


Trp Lys His Arg Arg Gln Glu Thr His Pro Tyr Tyr Asp Leu Gln Val 
        35                  40                  45              


Lys Val Leu Arg Ala Arg Asn Ile Gln His Thr Asp Lys Leu Ser Lys 
    50                  55                  60                  


Ala Asp Cys Tyr Val Arg Leu Trp Leu Pro Thr Ala Ser Val Ser Pro 
65                  70                  75                  80  


Ser Gln Thr Arg Thr Val Val Asn Ser Ser Asp Pro Glu Trp Asn Glu 
                85                  90                  95      


Thr Phe His Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu 
            100                 105                 110         


Ala Leu Tyr Asp Glu Asp Val Leu Asp Ser Asp Asn Val Phe Ser Ile 
        115                 120                 125             


Leu Phe Asp Met Ser Thr Leu Gln Leu Gly Gln Pro Cys Thr Lys Asn 
    130                 135                 140                 


Phe Thr Arg Gln Gln Asp Pro Lys Glu Leu Glu Val Glu Phe Thr Leu 
145                 150                 155                 160 


Glu Lys Ser Gln Thr Pro Ala Ser Glu Val Val Thr Asn Gly Val Leu 
                165                 170                 175     


Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Val Thr Gly Asp Lys 
            180                 185                 190         


Thr Ala Ser Leu Gly Glu Leu Gly Ser Arg Gln Ile Gln Leu Ala Val 
        195                 200                 205             


Pro Gly Ala Tyr Glu Lys Pro Gln Pro Leu Gln Pro Thr Ser Glu Pro 
    210                 215                 220                 


Gly Leu Pro Val Asn Phe Thr Phe His Met Asn Pro Val Leu Ser Pro 
225                 230                 235                 240 


Lys Leu His Ile Lys Leu Gln Glu Gln Leu Gln Val Phe His Ser Gly 
                245                 250                 255     


Pro Ser Asp Glu Leu Glu Ala Gln Thr Ser Lys Met Asp Lys Ala Ser 
            260                 265                 270         


Ile Leu Leu Ser Ser Leu Pro Leu Asn Glu Glu Leu Thr Lys Leu Val 
        275                 280                 285             


Asp Leu Glu Glu Gly Gln Gln Val Thr Leu Arg Met Lys Ala Asp Met 
    290                 295                 300                 


Ser Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu Cys Asp 
305                 310                 315                 320 


Gly Glu Gln Glu Phe Leu Asp Lys Arg Lys Gln Val Ala Ser Lys Ala 
                325                 330                 335     


Leu Gln Arg Val Met Gly Leu Ser Glu Ala Leu His Cys Asp Gln Val 
            340                 345                 350         


Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala Met Thr 
        355                 360                 365             


Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Leu Leu Asp 
    370                 375                 380                 


Ala Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Ser Trp Cys Ile Ser 
385                 390                 395                 400 


Thr Leu Tyr Arg Asp Pro Ser Trp Ser Gln Lys Ala Leu Gln Gly Pro 
                405                 410                 415     


Ile Lys Tyr Ala Ser Glu Arg Val Cys Ser Ser Lys Ile Gly Met Leu 
            420                 425                 430         


Ser Pro Lys Gln Phe Glu Tyr Tyr Ser Arg Glu Lys Arg Ala Trp Glu 
        435                 440                 445             


Ser Arg Gly His Ser Met Ser Phe Thr Asp Leu Trp Gly Leu Ile Ile 
    450                 455                 460                 


Glu Tyr Phe Leu Asn Gln Glu Glu Asn Pro Ala Lys Leu Ser Asp Gln 
465                 470                 475                 480 


Gln Glu Thr Val Ser Gln Gly Gln Asn Pro Tyr Pro Ile Tyr Ala Ser 
                485                 490                 495     


Ile Asn Val His Lys Asn Ile Ser Gly Asp Tyr Phe Ala Glu Trp Cys 
            500                 505                 510         


Glu Phe Thr Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Val Tyr Val 
        515                 520                 525             


Pro Thr Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Arg Leu Leu His 
    530                 535                 540                 


Phe Trp Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Trp Gly Ser 
545                 550                 555                 560 


Ala Phe Ala Ala Ser Leu Tyr Glu Ile Phe Leu Lys Leu Gly Gly Leu 
                565                 570                 575     


Ser Leu Ser Phe Leu Asp Trp His Arg Gly Ser Val Ser Val Thr Asp 
            580                 585                 590         


Asp Trp Pro Lys Leu Arg Lys Gln Asp Pro Thr Arg Leu Pro Thr Arg 
        595                 600                 605             


Leu Phe Thr Pro Met Ser Ser Phe Ser Gln Ala Val Leu Asp Ile Phe 
    610                 615                 620                 


Thr Ser Arg Ile Thr Cys Ala Gln Thr Phe Asn Phe Thr Arg Gly Leu 
625                 630                 635                 640 


Cys Met Tyr Lys Asp Tyr Thr Ala Arg Lys Asp Phe Val Val Ser Glu 
                645                 650                 655     


Asp Ala Trp His Ser His Asn Tyr Gly Tyr Pro Asp Ala Cys Pro Asn 
            660                 665                 670         


Gln Leu Thr Pro Met Lys Asp Phe Leu Ser Leu Val Asp Gly Gly Phe 
        675                 680                 685             


Ala Ile Asn Ser Pro Phe Pro Leu Val Leu Gln Pro Gln Arg Ala Val 
    690                 695                 700                 


Asp Leu Ile Val Ser Phe Asp Tyr Ser Leu Glu Gly Pro Phe Glu Val 
705                 710                 715                 720 


Leu Gln Val Thr Glu Lys Tyr Cys Arg Asp Arg Gly Ile Pro Phe Pro 
                725                 730                 735     


Arg Ile Glu Val Asp Pro Lys Asp Ser Glu Asp Pro Arg Glu Cys Tyr 
            740                 745                 750         


Leu Phe Thr Glu Ala Glu Asp Pro Cys Ser Pro Ile Val Leu His Phe 
        755                 760                 765             


Pro Leu Val Asn Arg Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu 
    770                 775                 780                 


Arg Gln Thr Ala Glu Glu Lys Ala Phe Gly Asp Phe Ile Ile Asn Gly 
785                 790                 795                 800 


Pro Asp Thr Ala Tyr Gly Met Met Asp Phe Thr Tyr Glu Pro Lys Glu 
                805                 810                 815     


Phe Asp Arg Leu Val Thr Leu Ser Arg Tyr Asn Val Leu Asn Asn Lys 
            820                 825                 830         


Glu Thr Ile Arg His Ala Leu Gln Leu Ala Leu Asp Arg Arg Arg Gln 
        835                 840                 845             


Ala Gly Gly Arg Val Gly Gly 
    850                 855 


<210>  36
<211>  825
<212>  PRT
<213>  Mus musculus

<400>  36

Met Trp Ser Gly Asp Arg Arg Val Gly Met Glu Ser Leu Ser Pro Glu 
1               5                   10                  15      


Arg Leu His Gly His Pro Tyr Gln Glu Glu Ala Ser Val Phe Cys Arg 
            20                  25                  30          


Leu Thr Val Lys Ile Leu Glu Ala Arg Ser Leu Pro Arg Ala Asp Leu 
        35                  40                  45              


Leu Ser Gln Ala Asp Pro Tyr Val Thr Val Gln Leu Pro Thr Ala Ser 
    50                  55                  60                  


Gly Met Lys Phe Lys Thr Gln Thr Val Thr Asn Ser Ser His Pro Val 
65                  70                  75                  80  


Trp Asn Glu Thr Phe Ser Phe Leu Ile Gln Ser Gln Val Lys Asn Ile 
                85                  90                  95      


Leu Glu Leu Thr Ile Tyr Asp Glu Asp Val Ile Thr Lys Asp Asp Ile 
            100                 105                 110         


Cys Phe Lys Val Ser Tyr Asp Val Ser Glu Ile Leu Pro Gly Gln Leu 
        115                 120                 125             


Leu Gln Lys Thr Phe Ser Leu Asn Pro Gln Gly Pro Glu Glu Leu Asp 
    130                 135                 140                 


Val Glu Leu Leu Met Glu Arg Thr Trp Asp Pro Pro Glu Asn Leu Ile 
145                 150                 155                 160 


Thr Asn Asn Val Leu Val Ala Arg Glu Leu Ser His Leu Asp Val Ser 
                165                 170                 175     


Leu Asp Arg Ala Gly Asn Thr Ala Met Ala Ala Gly Gln Asp Lys Leu 
            180                 185                 190         


Glu Leu Glu Leu Met Leu Lys Gly Ser Tyr Glu Asp Thr Gln Thr Phe 
        195                 200                 205             


Phe Pro Asp Thr Ala Phe Thr Phe Ser Phe His Tyr Met Gly Gly Gln 
    210                 215                 220                 


Asp Thr Glu Leu Asn Gly Tyr Leu Arg Gly Pro Arg Asn Ser Gly Trp 
225                 230                 235                 240 


Asn Ser Asp Thr Ser Val Thr Pro Phe Asn Val Pro Leu Met Ser Leu 
                245                 250                 255     


Ala Ala Gly Lys Glu Met Thr Ile Asp Ile Pro Ala Met Lys Ala Pro 
            260                 265                 270         


Glu Gly Lys Leu Gln Leu Lys Thr Asp Cys Cys Pro Lys Glu Leu Ser 
        275                 280                 285             


Val Arg Leu Ser Tyr Gly Leu Cys Pro Glu Glu Gln Ala Phe Leu Ser 
    290                 295                 300                 


Arg Arg Lys Lys Val Val Ala Ala Ala Leu Lys Gln Ala Leu Gln Leu 
305                 310                 315                 320 


Asp Glu Asp Leu Asn Glu Asp Glu Val Pro Val Val Gly Ile Asn Ala 
                325                 330                 335     


Glu Gly Gly Gly Met Arg Ala Met Ile Ser Leu Tyr Gly His Leu Leu 
            340                 345                 350         


Ala Leu Gln Lys Leu Gly Leu Leu Asp Cys Val Thr Tyr Phe Ser Gly 
        355                 360                 365             


Ile Ser Gly Ser Thr Trp Thr Met Ala His Leu Tyr Arg Asp Pro Glu 
    370                 375                 380                 


Trp Ser Gln Arg Asp Leu Glu Gly Pro Ile Ser His Ala Arg Glu His 
385                 390                 395                 400 


Val Ala Lys Thr Leu Leu Lys Glu Phe Leu Pro Glu His Leu Ala Ser 
                405                 410                 415     


Tyr Arg Gln Thr Leu Lys Leu Arg Glu Glu Gln Gly Tyr Thr Val Thr 
            420                 425                 430         


Val Ala Asp Leu Trp Gly Leu Val Leu Glu Ser Lys Leu His Gly Gln 
        435                 440                 445             


Val Thr Asp Gln Lys Leu Ser Gly Gln Arg Ala Ala Leu Glu Arg Gly 
    450                 455                 460                 


Gln Asn Pro Leu Pro Leu Tyr Leu Ser Leu Asn Val Lys Glu Asn His 
465                 470                 475                 480 


Leu Gly Thr Leu His Phe Lys Glu Trp Val Glu Phe Ser Pro Tyr Glu 
                485                 490                 495     


Val Gly Phe Leu Lys Tyr Gly Gly Phe Val Pro Ser Glu Leu Phe Gly 
            500                 505                 510         


Ser Glu Phe Phe Met Gly Arg Leu Met Lys Arg Leu Pro Glu Ser Gln 
        515                 520                 525             


Ile Cys Phe Leu Glu Gly Ile Trp Ser Asn Leu Phe Ser Val Asn Leu 
    530                 535                 540                 


Met Asp Ile Trp Tyr Asp Ile Thr Tyr Gly Lys Asp Ser Asn Asn Phe 
545                 550                 555                 560 


Pro Val Asp Val Arg Asn Ser Glu Lys Glu Phe Ser Gly Ser Ala Gly 
                565                 570                 575     


Thr Ser Ser Gly Val Glu Ala Pro Trp Leu Glu Ser Gly Thr Ala Leu 
            580                 585                 590         


Ala Gln Ala Leu Lys Gly Phe Leu Thr Gly Arg Pro Phe His Gln Arg 
        595                 600                 605             


Ser Ala Asn Phe Leu His Gly Leu Gln Leu His Arg Asp Tyr Cys Asn 
    610                 615                 620                 


Gln Arg His Phe Ser Thr Trp Ala Asp Cys Asn Leu Asp Asp Thr Pro 
625                 630                 635                 640 


Asn Gln Leu Thr Pro Gln Asp Pro Gln Leu Cys Leu Ile Asp Ala Gly 
                645                 650                 655     


Cys Phe Met Asn Ser Ser Cys Pro Ser Leu Phe Arg Pro Gly Arg Gln 
            660                 665                 670         


Val Asp Leu Ile Ile Ser Phe Asn Tyr Asn Gln Ser Leu Pro Phe Lys 
        675                 680                 685             


Gly Leu Gln Gln Ser Glu Lys Tyr Ser Arg Ala Arg Gly Leu Pro Phe 
    690                 695                 700                 


Pro Arg Val Glu Pro Ser Pro Glu Asp His Ser Gln Pro Gln Glu Cys 
705                 710                 715                 720 


Tyr Leu Phe Ser Asp Pro Thr Cys Pro Glu Ala Pro Val Val Leu His 
                725                 730                 735     


Phe Pro Leu Val Asn Asp Ser Phe Arg Asp His Ser Ala Pro Gly Val 
            740                 745                 750         


Arg Arg Ser Pro Asp Glu Leu Lys Ala Gly Gln Val Asn Leu Thr Gly 
        755                 760                 765             


Ala Ala Ser Pro Tyr Phe Met Tyr Asn Met Thr Tyr Lys Asn Glu Asp 
    770                 775                 780                 


Phe Asp Arg Leu Leu Gln Leu Ser Asp Tyr Asn Val Gln Asn Asn Gln 
785                 790                 795                 800 


Gly Thr Ile Leu Gln Ala Leu Arg Thr Val Leu Lys Arg Arg Ala Ser 
                805                 810                 815     


Glu Thr Arg Pro Leu Gly Val Lys Thr 
            820                 825 


<210>  37
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Leu Leu Leu Leu Leu Pro Ser Leu Leu Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Gly Pro Gly Ser Gly Glu Ala Ser Arg Ile Leu Arg Val His Arg Arg 
            20                  25                  30          


Gly Ile Leu Glu Leu Ala Gly Thr Val Gly Cys Val Gly Pro Arg Thr 
        35                  40                  45              


Pro Ile Ala Tyr Met Lys Tyr Gly Cys Phe Cys Gly Leu Gly Gly His 
    50                  55                  60                  


Gly Gln Pro Arg Asp Ala Ile Asp Trp Cys Cys His Gly His Asp Cys 
65                  70                  75                  80  


Cys Tyr Thr Arg Ala Glu Glu Ala Gly Cys Ser Pro Lys Thr Glu Arg 
                85                  90                  95      


Tyr Ser Trp Gln Cys Val Asn Gln Ser Val Leu Cys Gly Pro Ala Glu 
            100                 105                 110         


Asn Lys Cys Gln Glu Leu Leu Cys Lys Cys Asp Gln Glu Ile Ala Asn 
        115                 120                 125             


Cys Leu Ala Gln Thr Glu Tyr Asn Leu Lys Tyr Leu Phe Tyr Pro Gln 
    130                 135                 140                 


Phe Leu Cys Glu Pro Asp Ser Pro Lys Cys Asp 
145                 150                 155 


<210>  38
<211>  144
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  38

Met Lys Phe Leu Val Leu Ala Ala Leu Leu Thr Ala Gly Thr Ala Ala 
1               5                   10                  15      


Ser Gly Val Ser Pro Thr Ala Leu Trp Gln Phe Arg Gly Met Ile Gln 
            20                  25                  30          


Cys Thr Ile Pro Gly Ser Ser Pro Tyr Leu Glu Phe Asn Gly Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Arg Cys Cys Gln Thr His Asp Gln Cys Tyr Thr Gln Ala Lys Lys Leu 
65                  70                  75                  80  


Ser Ser Cys Ser Phe Leu Val Asp Asn Pro Tyr Thr Asn Ser Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Gly Thr Thr Val Thr Cys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Cys Glu Ala Phe Ile Cys Asp Cys Asp Arg Lys Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Arg Pro Tyr Asn Lys Glu Tyr Lys Pro Ile Ser Lys Tyr Cys 
    130                 135                 140                 


<210>  39
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  39

Met Lys Gly Leu Leu Thr Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15      


Ala Val Pro Gly Gly Leu Leu Glu Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30          


Thr Gly Lys Asn Ala Phe Lys Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys 
    50                  55                  60                  


Gln Met His Asp Arg Cys Tyr Gly Gln Leu Glu Glu Lys Asp Cys Ala 
65                  70                  75                  80  


Ile Arg Thr Gln Ser Tyr Asp Tyr Arg Tyr Thr Asn Gly Leu Val Ile 
                85                  90                  95      


Cys Glu His Asp Ser Phe Cys Pro Met Arg Leu Cys Ala Cys Asp Arg 
            100                 105                 110         


Lys Leu Val Tyr Cys Leu Arg Arg Asn Leu Trp Thr Tyr Asn Pro Leu 
        115                 120                 125             


Tyr Gln Tyr Tyr Pro Asn Phe Leu Cys 
    130                 135         


<210>  40
<211>  137
<212>  PRT
<213>  Rattus norvegicus

<400>  40

Met Lys Arg Leu Leu Thr Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15      


Ala Val Pro Gly Gly Leu Leu Glu Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30          


Thr Gly Lys Asn Ala Val Lys Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Trp Gly Gly His Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys 
    50                  55                  60                  


Arg Met His Asp Arg Cys Tyr Gly Leu Leu Glu Glu Lys His Cys Ala 
65                  70                  75                  80  


Ile Arg Thr Gln Ser Tyr Asp Tyr Arg Phe Thr Gln Asp Leu Val Ile 
                85                  90                  95      


Cys Glu His Asp Ser Phe Cys Pro Val Arg Leu Cys Ala Cys Asp Arg 
            100                 105                 110         


Lys Leu Val Tyr Cys Leu Arg Arg Asn Leu Trp Ser Tyr Asn Arg Leu 
        115                 120                 125             


Tyr Gln Tyr Tyr Pro Asn Phe Leu Cys 
    130                 135         


<210>  41
<211>  145
<212>  PRT
<213>  Cavia porcellus

<400>  41

Met Lys Leu Leu Leu Leu Leu Leu Val Val Met Ala Ser Asp Leu Pro 
1               5                   10                  15      


Gln Ala His Gly His Leu Lys Gln Phe Thr Glu Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Asn Gly Leu Thr Ser Tyr Gly Ala Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Lys Gly Thr Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Arg His Asp Cys Cys Tyr Asp Arg Leu Met Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Asn Tyr Arg Phe Thr His Lys Gly Ser Ser Ile Thr 
                85                  90                  95      


Cys Ser Val Lys Gln Asn Ser Cys Gln Lys Gln Leu Cys Glu Cys Asp 
            100                 105                 110         


Lys Ala Ala Ala Tyr Cys Phe Ala Ala Asn Leu Lys Ser Tyr Ser Arg 
        115                 120                 125             


Arg Tyr Gln Phe Tyr Tyr Asn Gly Leu Cys Arg Gly Lys Thr Pro Ser 
    130                 135                 140                 


Cys 
145 


<210>  42
<211>  150
<212>  PRT
<213>  Mus musculus

<400>  42

Met Lys Gly Ile Ala Ile Phe Leu Val Phe Ile Phe Tyr Trp Thr Thr 
1               5                   10                  15      


Ser Thr Leu Ser Ser Phe Trp Gln Phe Gln Arg Met Val Lys His Val 
            20                  25                  30          


Thr Gly Arg Ser Ala Phe Phe Ser Tyr Tyr Gly Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Leu Gly Gly Lys Gly Leu Pro Val Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Trp Ala His Asp Cys Cys Tyr His Lys Leu Lys Glu Tyr Gly Cys Gln 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Tyr Gln Phe Thr Ile Val Asn Gly Thr Val Thr 
                85                  90                  95      


Cys Gly Cys Thr Val Ala Ser Ser Cys Pro Cys Gly Gln Lys Ala Cys 
            100                 105                 110         


Glu Cys Asp Lys Gln Ser Val Tyr Cys Phe Lys Glu Asn Leu Ala Thr 
        115                 120                 125             


Tyr Glu Lys Ala Phe Lys Gln Leu Phe Pro Thr Arg Pro Gln Cys Gly 
    130                 135                 140                 


Arg Asp Lys Leu Gln Cys 
145                 150 


<210>  43
<211>  146
<212>  PRT
<213>  Cavia porcellus

<400>  43

Met Lys Leu Leu Val Leu Ala Ala Leu Leu Ser Val Ser Ala Ala Ala 
1               5                   10                  15      


His Ile Ile Thr Pro Arg Ala Leu Trp Gln Phe Arg Asp Met Ile Lys 
            20                  25                  30          


Cys Ala Ile Pro Gly Ser Arg Pro Tyr Ser Glu Tyr Asn Asn Tyr Gly 
        35                  40                  45              


Cys Phe Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Arg Cys Cys Glu Ile His Asp Ala Cys Tyr Thr Gln Ala Lys His Leu 
65                  70                  75                  80  


Glu Ser Cys Lys Ser Val Ile Asp Asn Pro Tyr Thr Asn Ser Tyr Ser 
                85                  90                  95      


Phe Ser Cys Ser Gly Thr Asn Ile Ile Cys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Cys Glu Glu Phe Ile Cys Asn Cys Asp Arg Ala Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Ala Pro Tyr Asn Glu Asn Asn Lys Asn Ile Asn Lys Lys Glu 
    130                 135                 140                 


Arg Cys 
145     


<210>  44
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  44

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  45
<211>  849
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Leu Trp Ala Leu Trp Pro Arg Trp Leu Ala Asp Lys Met Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ala Val Leu Leu Gln Lys Arg Glu Lys Arg Gly Pro Leu 
            20                  25                  30          


Trp Arg His Trp Arg Arg Glu Thr Tyr Pro Tyr Tyr Asp Leu Gln Val 
        35                  40                  45              


Lys Val Leu Arg Ala Thr Asn Ile Arg Gly Thr Asp Leu Leu Ser Lys 
    50                  55                  60                  


Ala Asp Cys Tyr Val Gln Leu Trp Leu Pro Thr Ala Ser Pro Ser Pro 
65                  70                  75                  80  


Ala Gln Thr Arg Ile Val Ala Asn Cys Ser Asp Pro Glu Trp Asn Glu 
                85                  90                  95      


Thr Phe His Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu 
            100                 105                 110         


Thr Leu Tyr Asp Lys Asp Ile Leu Gly Ser Asp Gln Leu Ser Leu Leu 
        115                 120                 125             


Leu Phe Asp Leu Arg Ser Leu Lys Cys Gly Gln Pro His Lys His Thr 
    130                 135                 140                 


Phe Pro Leu Asn His Gln Asp Ser Gln Glu Leu Gln Val Glu Phe Val 
145                 150                 155                 160 


Leu Glu Lys Ser Gln Val Pro Ala Ser Glu Val Ile Thr Asn Gly Val 
                165                 170                 175     


Leu Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Leu Arg Gly Asp 
            180                 185                 190         


Gly Thr Ala Pro Arg Glu Glu Tyr Gly Ser Arg Gln Leu Gln Leu Ala 
        195                 200                 205             


Val Pro Gly Ala Tyr Glu Lys Pro Gln Leu Leu Pro Leu Gln Pro Pro 
    210                 215                 220                 


Thr Glu Pro Gly Leu Pro Pro Thr Phe Thr Phe His Val Asn Pro Val 
225                 230                 235                 240 


Leu Ser Ser Arg Leu His Val Glu Leu Met Glu Leu Leu Ala Ala Val 
                245                 250                 255     


Gln Ser Gly Pro Ser Ala Glu Leu Glu Ala Gln Thr Ser Lys Leu Gly 
            260                 265                 270         


Glu Gly Gly Ile Leu Leu Ser Ser Leu Pro Leu Gly Gln Glu Glu Gln 
        275                 280                 285             


Cys Ser Val Ala Leu Gly Glu Gly Gln Glu Val Ala Leu Ser Met Lys 
    290                 295                 300                 


Val Glu Met Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu 
305                 310                 315                 320 


Ser Asp Gly Glu Gln Glu Phe Leu Asp Arg Arg Lys Gln Val Val Ser 
                325                 330                 335     


Lys Ala Leu Gln Gln Val Leu Gly Leu Ser Glu Ala Leu Asp Ser Gly 
            340                 345                 350         


Gln Val Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala 
        355                 360                 365             


Met Ser Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Leu 
    370                 375                 380                 


Leu Asp Thr Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Thr Trp Cys 
385                 390                 395                 400 


Ile Ser Thr Leu Tyr Arg Asp Pro Ala Trp Ser Gln Val Ala Leu Gln 
                405                 410                 415     


Gly Pro Ile Glu Arg Ala Gln Val His Val Cys Ser Ser Lys Met Gly 
            420                 425                 430         


Ala Leu Ser Thr Glu Arg Leu Gln Tyr Tyr Thr Gln Glu Leu Gly Val 
        435                 440                 445             


Arg Glu Arg Ser Gly His Ser Val Ser Leu Ile Asp Leu Trp Gly Leu 
    450                 455                 460                 


Leu Val Glu Tyr Leu Leu Tyr Gln Glu Glu Asn Pro Ala Lys Leu Ser 
465                 470                 475                 480 


Asp Gln Gln Glu Ala Val Arg Gln Gly Gln Asn Pro Tyr Pro Ile Tyr 
                485                 490                 495     


Thr Ser Val Asn Val Arg Thr Asn Leu Ser Gly Glu Asp Phe Ala Glu 
            500                 505                 510         


Trp Cys Glu Phe Thr Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala 
        515                 520                 525             


Tyr Val Pro Thr Glu Leu Phe Gly Ser Glu Leu Phe Met Gly Arg Leu 
    530                 535                 540                 


Leu Gln Leu Gln Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Trp 
545                 550                 555                 560 


Gly Ser Ala Phe Ala Thr Ser Leu Asp Glu Ile Phe Leu Lys Thr Ala 
                565                 570                 575     


Gly Ser Gly Leu Ser Phe Leu Glu Trp Tyr Arg Gly Ser Val Asn Ile 
            580                 585                 590         


Thr Asp Asp Cys Gln Lys Pro Gln Leu His Asn Pro Ser Arg Leu Arg 
        595                 600                 605             


Thr Arg Leu Leu Thr Pro Gln Gly Pro Phe Ser Gln Ala Val Leu Asp 
    610                 615                 620                 


Ile Phe Thr Ser Arg Phe Thr Ser Ala Gln Ser Phe Asn Phe Thr Arg 
625                 630                 635                 640 


Gly Leu Cys Leu His Lys Asp Tyr Val Ala Gly Arg Glu Phe Val Ala 
                645                 650                 655     


Trp Lys Asp Thr His Pro Asp Ala Phe Pro Asn Gln Leu Thr Pro Met 
            660                 665                 670         


Arg Asp Cys Leu Tyr Leu Val Asp Gly Gly Phe Ala Ile Asn Ser Pro 
        675                 680                 685             


Phe Pro Leu Ala Leu Leu Pro Gln Arg Ala Val Asp Leu Ile Leu Ser 
    690                 695                 700                 


Phe Asp Tyr Ser Leu Glu Ala Pro Phe Glu Val Leu Lys Met Thr Glu 
705                 710                 715                 720 


Lys Tyr Cys Leu Asp Arg Gly Ile Pro Phe Pro Ser Ile Glu Val Gly 
                725                 730                 735     


Pro Glu Asp Val Glu Glu Ala Arg Glu Cys Tyr Leu Phe Ala Lys Ala 
            740                 745                 750         


Glu Asp Pro Arg Ser Pro Ile Val Leu His Phe Pro Leu Val Asn Arg 
        755                 760                 765             


Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu Arg Gln Thr Ala Glu 
    770                 775                 780                 


Glu Lys Ala Phe Gly Asp Phe Val Ile Asn Arg Pro Asp Thr Pro Tyr 
785                 790                 795                 800 


Gly Met Met Asn Phe Thr Tyr Glu Pro Gln Asp Phe Tyr Arg Leu Val 
                805                 810                 815     


Ala Leu Ser Arg Tyr Asn Val Leu Asn Asn Val Glu Thr Leu Lys Cys 
            820                 825                 830         


Ala Leu Gln Leu Ala Leu Asp Arg His Gln Ala Arg Glu Arg Ala Gly 
        835                 840                 845             


Ala 
    


<210>  46
<211>  1012
<212>  PRT
<213>  Mus musculus

<400>  46

Met Ala Glu Ala Ala Leu Glu Ala Val Arg Arg Ala Leu Gln Glu Phe 
1               5                   10                  15      


Pro Ala Ala Ala Arg Asp Leu Asn Val Pro Arg Val Val Pro Tyr Leu 
            20                  25                  30          


Asp Glu Pro Pro Ser Pro Leu Cys Phe Tyr Arg Asp Trp Val Cys Pro 
        35                  40                  45              


Asn Arg Pro Cys Ile Ile Arg Asn Ala Leu Gln His Trp Pro Ala Leu 
    50                  55                  60                  


Gln Lys Trp Ser Leu Ser Tyr Leu Arg Ala Thr Val Gly Ser Thr Glu 
65                  70                  75                  80  


Val Ser Val Ala Val Thr Pro Asp Gly Tyr Ala Asp Ala Val Arg Gly 
                85                  90                  95      


Asp Arg Phe Val Met Pro Ala Glu Arg Arg Leu Pro Ile Ser His Val 
            100                 105                 110         


Leu Asp Val Leu Glu Gly Arg Ala Gln His Pro Gly Val Leu Tyr Val 
        115                 120                 125             


Gln Lys Gln Cys Ser Asn Leu Pro Thr Glu Leu Pro Gln Leu Leu Ser 
    130                 135                 140                 


Asp Ile Glu Ser His Val Pro Trp Ala Ser Glu Ser Leu Gly Lys Met 
145                 150                 155                 160 


Pro Asp Ala Val Asn Phe Trp Leu Gly Asp Ala Ser Ala Val Thr Ser 
                165                 170                 175     


Leu His Lys Asp His Tyr Glu Asn Leu Tyr Cys Val Val Ser Gly Glu 
            180                 185                 190         


Lys His Phe Leu Leu His Pro Pro Ser Asp Arg Pro Phe Ile Pro Tyr 
        195                 200                 205             


Asn Leu Tyr Thr Pro Ala Thr Tyr Gln Leu Thr Glu Glu Gly Thr Phe 
    210                 215                 220                 


Arg Val Val Asp Glu Glu Ala Met Glu Lys Val Pro Glu Thr Cys Leu 
225                 230                 235                 240 


Leu Thr Val Arg Val Leu Arg Ala Ser Gly Leu Pro Ser Lys Asp Leu 
                245                 250                 255     


Val Thr Ser Ser Asp Cys Tyr Val Thr Leu Asn Leu Pro Thr Ala Ser 
            260                 265                 270         


Ser His Thr Leu Gln Thr Arg Thr Val Lys Asn Ser Arg Asn Pro Val 
        275                 280                 285             


Trp Asn Gln Asn Phe His Phe Arg Ile His Arg Gln Leu Lys Asn Val 
    290                 295                 300                 


Ile Glu Leu Lys Ala Phe Asp His Asp Leu Val Thr Arg Asp Asp Pro 
305                 310                 315                 320 


Val Leu Ser Val Leu Phe Asp Val Gly Thr Leu Gln Ile Gly Thr Gln 
                325                 330                 335     


Arg Gln Ser Phe Ser Leu Gly Thr Gln Glu Lys Gly Cys Leu Glu Val 
            340                 345                 350         


Glu Phe Arg Leu Gln Thr Leu Thr Asp Cys Glu Glu Gln Leu Ile Ser 
        355                 360                 365             


Asn Gly Ile Val Val Ala Arg Glu Leu Ser Cys Leu His Val Glu Leu 
    370                 375                 380                 


Lys Arg Thr Gly Asp Pro Lys Arg Ser Glu Arg Lys Val Gln Leu Val 
385                 390                 395                 400 


Val Ala Gly Ala Cys Glu Gly Pro Gln Asp Ala Ser Ala Gly Thr Gly 
                405                 410                 415     


Ser Phe His Phe His Tyr Pro Ala Cys Trp Glu Gln Glu Leu Asn Val 
            420                 425                 430         


His Leu Gln Asp Asp Pro His Glu Gln Leu Lys Val Pro Leu Arg Thr 
        435                 440                 445             


Leu Pro Ser Ser Gln Leu Val Arg Leu Val Phe Pro Thr Ser Gln Glu 
    450                 455                 460                 


Pro Leu Met Arg Leu Glu Leu Lys Lys Glu Glu Gly Pro Lys Glu Leu 
465                 470                 475                 480 


Ala Val Arg Leu Gly Cys Gly Pro Cys Pro Glu Glu Gln Ala Phe Leu 
                485                 490                 495     


Ser Lys Arg Lys Gln Val Val Ala Ala Ala Leu Lys Lys Ala Leu Gln 
            500                 505                 510         


Leu Asp Gln Asp Leu His Glu Asp Glu Ile Pro Val Ile Ala Val Met 
        515                 520                 525             


Ala Thr Gly Gly Gly Ile Arg Ala Met Thr Ser Leu Tyr Gly Gln Leu 
    530                 535                 540                 


Ala Gly Leu Gln Glu Leu Gly Leu Leu Asp Cys Ile Ser Tyr Ile Thr 
545                 550                 555                 560 


Gly Ala Ser Gly Ser Thr Trp Ala Leu Ala Asn Leu Tyr Glu Asp Pro 
                565                 570                 575     


Glu Trp Ser Gln Lys Asp Leu Ala Gly Pro Thr Glu Val Leu Lys Thr 
            580                 585                 590         


Gln Val Thr Lys Ser Lys Leu Gly Ala Leu Ala Pro Ser Gln Leu Trp 
        595                 600                 605             


Arg Tyr Arg Gln Glu Leu Ala Glu Arg Ala Arg Leu Gly His Pro Thr 
    610                 615                 620                 


Cys Phe Thr Asn Leu Trp Ala Leu Ile Asn Glu Ala Leu Leu His Asp 
625                 630                 635                 640 


Lys Pro His Glu His Lys Leu Ser Asp Gln Arg Glu Ala Leu Ser Arg 
                645                 650                 655     


Gly Gln Asn Pro Leu Pro Ile Tyr Cys Ala Leu Asn Ser Lys Glu Gln 
            660                 665                 670         


Gly Leu Ser Thr Phe Asp Phe Gly Glu Trp Cys Glu Phe Ser Pro Tyr 
        675                 680                 685             


Glu Val Gly Phe Pro Lys Tyr Gly Ala Phe Ile Ser Ser Glu Leu Phe 
    690                 695                 700                 


Gly Ser Glu Phe Phe Met Gly Arg Leu Val Lys Gln Leu Pro Glu Ser 
705                 710                 715                 720 


Arg Ile Cys Phe Leu Glu Gly Ile Trp Ser Asn Leu Phe Ala Ala Ser 
                725                 730                 735     


Leu Gln Asp Ser Leu Tyr Trp Ser Ser Glu Pro Ser Gln Phe Trp Asp 
            740                 745                 750         


Arg Trp Ala Gln Asp Gln Ala Asn Leu Asp Lys Glu Gln Val Pro His 
        755                 760                 765             


Leu Lys Ile Ala Glu Pro Pro Thr Met Ala Gly Arg Ile Ala Glu Leu 
    770                 775                 780                 


Phe Thr Asp Leu Leu Thr Lys Arg Pro Leu Ala His Ala Thr His Asn 
785                 790                 795                 800 


Phe Thr Arg Gly Leu His Phe His Lys Asp Tyr Phe Gln Asn Ser His 
                805                 810                 815     


Phe Ser Ala Trp Lys Ala Ser Lys Leu Asp Arg Leu Pro Asn Gln Leu 
            820                 825                 830         


Thr Pro Thr Glu Pro His Leu Cys Leu Leu Asp Val Gly Tyr Leu Ile 
        835                 840                 845             


Asn Thr Ser Cys Pro Pro Leu Leu Gln Pro Thr Arg Asp Val Asp Leu 
    850                 855                 860                 


Ile Leu Ser Leu Asp Tyr Asn Leu Tyr Gly Ala Phe Gln Gln Leu Gln 
865                 870                 875                 880 


Leu Leu Ser Arg Phe Cys Gln Glu Gln Gly Ile Pro Phe Pro Ser Ile 
                885                 890                 895     


Ser Pro Ser Pro Glu Glu Gln Arg Gln Pro Gln Glu Cys His Leu Phe 
            900                 905                 910         


Cys Asp Pro Ala Gln Pro Glu Ala Pro Ala Val Leu His Phe Pro Leu 
        915                 920                 925             


Val Asn Asp Ser Phe Gln Asp Tyr Ser Ala Pro Gly Val Pro Arg Thr 
    930                 935                 940                 


Ser Glu Glu Lys Ala Ala Gly Glu Val Asn Leu Ser Ser Ser Asp Ser 
945                 950                 955                 960 


Pro Tyr His Tyr Thr Lys Val Thr Tyr Ser Gln Glu Asp Val Asp Lys 
                965                 970                 975     


Leu Leu Arg Leu Thr His Tyr Asn Ile Cys Asn Asn Gln Asp Arg Leu 
            980                 985                 990         


Arg Glu Ala Met His Gln Ala Val  Gln Arg Arg Arg Lys  Arg Lys Gln 
        995                 1000                 1005             


Phe Arg  Pro Glu 
    1010         


<210>  47
<211>  751
<212>  PRT
<213>  Rattus norvegicus

<400>  47

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Ala Lys Glu Val Ser Leu Ala Asp Tyr 
            20                  25                  30          


Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Ala Ser Asn Arg Thr Trp Asp Cys Asp Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Asp Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Val 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Glu Gln Val Leu His Val Glu Val Leu Gln Leu Thr Asp Leu 
            100                 105                 110         


Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu Leu 
        115                 120                 125             


Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Thr Cys Ala Asn 
    130                 135                 140                 


Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg 
145                 150                 155                 160 


Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Ala 
                165                 170                 175     


Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr Ala 
            180                 185                 190         


Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn Ala 
        195                 200                 205             


Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu His 
    210                 215                 220                 


Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu 
225                 230                 235                 240 


Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile His 
                245                 250                 255     


Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser 
            260                 265                 270         


Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser 
        275                 280                 285             


Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys 
    290                 295                 300                 


Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala Leu 
305                 310                 315                 320 


His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu Leu 
                325                 330                 335     


Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr Pro 
            340                 345                 350         


Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala Leu 
        355                 360                 365             


Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr 
    370                 375                 380                 


Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu Met 
385                 390                 395                 400 


Pro Val Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met Arg 
                405                 410                 415     


Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly Gly 
            420                 425                 430         


Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala 
        435                 440                 445             


Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser 
    450                 455                 460                 


Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala 
465                 470                 475                 480 


Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly 
                485                 490                 495     


Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu 
            500                 505                 510         


Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val Met 
        515                 520                 525             


Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe 
    530                 535                 540                 


Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Thr Pro 
545                 550                 555                 560 


Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val Trp 
                565                 570                 575     


Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn 
            580                 585                 590         


Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp 
        595                 600                 605             


Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys Gly 
    610                 615                 620                 


Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr 
625                 630                 635                 640 


Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg Pro 
                645                 650                 655     


Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu 
            660                 665                 670         


Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val 
        675                 680                 685             


Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg 
    690                 695                 700                 


Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser Asp 
705                 710                 715                 720 


Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu 
                725                 730                 735     


Tyr Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750     


<210>  48
<211>  144
<212>  PRT
<213>  Bos taurus

<400>  48

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ala Ile Gly Leu Leu 
1               5                   10                  15      


Gln Val His Gly Asp Leu Leu Asn Phe Arg Lys Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Pro Ala Thr Arg Tyr Ser Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Met Ser Gly Arg Gly Thr Pro Lys Asp Ala Thr Asp Trp Cys Cys 
    50                  55                  60                  


Arg Ala His Asp Cys Cys Tyr Lys Asn Leu Glu Ser Arg Gly Cys Arg 
65                  70                  75                  80  


Thr Lys Phe Leu Lys Tyr Asn Val Thr Tyr Gln Glu Asp Gln Ile Val 
                85                  90                  95      


Cys Glu Asp Ala Asp Asp Cys Lys Ser Gln Val Cys Gln Cys Asp Lys 
            100                 105                 110         


Ile Ala Ala Asn Cys Phe Ala Ala Asn Leu Lys Thr Tyr Asn Lys Lys 
        115                 120                 125             


Leu Arg Phe Tyr Asn Lys Phe Arg Cys Arg Gly Ala Ala Pro Ala Cys 
    130                 135                 140                 


<210>  49
<211>  151
<212>  PRT
<213>  Rattus norvegicus

<400>  49

Met Leu Leu Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Cys Leu 
1               5                   10                  15      


Ser Glu Ala Thr Arg Arg Ser His Val Tyr Lys Arg Gly Leu Leu Glu 
            20                  25                  30          


Leu Ala Gly Thr Leu Asp Cys Val Gly Pro Arg Ser Pro Met Ala Tyr 
        35                  40                  45              


Met Asn Tyr Gly Cys Tyr Cys Gly Leu Gly Gly His Gly Glu Pro Arg 
    50                  55                  60                  


Asp Ala Ile Asp Trp Cys Cys Tyr Tyr His Asp Cys Cys Tyr Ser Gln 
65                  70                  75                  80  


Ala Gln Asp Ala Gly Cys Ser Pro Lys Leu Tyr Arg Tyr Pro Trp Lys 
                85                  90                  95      


Cys Met Asp His Arg Ile Leu Cys Gly Pro Ala Glu Asn Lys Cys Gln 
            100                 105                 110         


Glu Leu Leu Cys Arg Cys Asp Glu Thr Leu Ala Tyr Cys Leu Ala Asp 
        115                 120                 125             


Thr Glu Tyr His Leu Lys Tyr Leu Phe Phe Pro Ser Val Leu Cys Glu 
    130                 135                 140                 


Lys Asp Ser Pro Lys Cys Asn 
145                 150     


<210>  50
<211>  146
<212>  PRT
<213>  Mus musculus

<400>  50

Met Lys Leu Leu Leu Leu Ala Ala Leu Leu Thr Ala Gly Ala Ala Ala 
1               5                   10                  15      


His Ser Ile Ser Pro Arg Ala Val Trp Gln Phe Arg Asn Met Ile Lys 
            20                  25                  30          


Cys Thr Ile Pro Gly Ser Asp Pro Leu Lys Asp Tyr Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Trp Gly Thr Pro Val Asp Asp Leu Asp 
    50                  55                  60                  


Arg Cys Cys Gln Thr His Asp His Cys Tyr Ser Gln Ala Lys Lys Leu 
65                  70                  75                  80  


Glu Ser Cys Lys Phe Leu Ile Asp Asn Pro Tyr Thr Asn Thr Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Gly Ser Glu Ile Thr Cys Ser Ala Lys Asn Asn Lys 
            100                 105                 110         


Cys Glu Asp Phe Ile Cys Asn Cys Asp Arg Glu Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Val Pro Tyr Asn Lys Glu Tyr Lys Asn Leu Asp Thr Gly Lys 
    130                 135                 140                 


Phe Cys 
145     


<210>  51
<211>  150
<212>  PRT
<213>  Rattus norvegicus

<400>  51

Met Lys Gly Ile Ala Val Phe Leu Val Phe Ile Phe Cys Trp Thr Thr 
1               5                   10                  15      


Ser Thr Leu Ser Ser Phe Trp Gln Phe Gln Arg Met Val Lys His Ile 
            20                  25                  30          


Thr Gly Arg Ser Ala Phe Phe Ser Tyr Tyr Gly Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Leu Gly Gly Arg Gly Ile Pro Val Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Trp Ala His Asp Cys Cys Tyr His Lys Leu Lys Glu Tyr Gly Cys Gln 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Tyr Gln Phe Ala Ile Val Asn Gly Thr Val Thr 
                85                  90                  95      


Cys Gly Cys Thr Met Gly Gly Gly Cys Leu Cys Gly Gln Lys Ala Cys 
            100                 105                 110         


Glu Cys Asp Lys Leu Ser Val Tyr Cys Phe Lys Glu Asn Leu Ala Thr 
        115                 120                 125             


Tyr Glu Lys Thr Phe Lys Gln Leu Phe Pro Thr Arg Pro Gln Cys Gly 
    130                 135                 140                 


Arg Asp Lys Leu His Cys 
145                 150 


<210>  52
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Leu Leu Arg Gln Met His Ala Arg Val Ser His Ser Leu Pro Asp 
1               5                   10                  15      


Pro Cys Gln Ala Glu Asp Ser Arg Pro Ser Ala Thr Cys Ala Leu Lys 
            20                  25                  30          


Ala Pro Gln Thr Ser Trp Asp Gly Leu Leu Arg Glu Gly Leu Ser Pro 
        35                  40                  45              


Cys His Leu Leu Thr Val Arg Val Ile Arg Met Lys Asn Val Arg Gln 
    50                  55                  60                  


Ala Asp Met Leu Ser Gln Thr Asp Cys Phe Val Ser Leu Trp Leu Pro 
65                  70                  75                  80  


Thr Ala Ser Gln Lys Lys Leu Arg Thr Arg Thr Ile Ser Asn Cys Pro 
                85                  90                  95      


Asn Pro Glu Trp Asn Glu Ser Phe Asn Phe Gln Ile Gln Ser Arg Val 
            100                 105                 110         


Lys Asn Val Leu Glu Leu Ser Val Cys Asp Glu Asp Thr Val Thr Pro 
        115                 120                 125             


Asp Asp His Leu Leu Thr Val Leu Tyr Asp Leu Thr Lys Leu Cys Phe 
    130                 135                 140                 


Arg Lys Lys Thr His Val Lys Phe Pro Leu Asn Pro Gln Gly Met Glu 
145                 150                 155                 160 


Glu Leu Glu Val Glu Phe Leu Leu Glu Glu Ser Pro Ser Pro Pro Glu 
                165                 170                 175     


Thr Leu Val Thr Asn Gly Val Leu Val Ser Arg Gly His Gly Trp Leu 
            180                 185                 190         


Leu Leu Ser Gly Glu Gln Asp Gln Gly Arg Lys Gln Trp Ala Lys Asp 
        195                 200                 205             


Leu Leu Val Met Val Asn Glu Ser Phe Glu Asn Thr Gln Arg Val Arg 
    210                 215                 220                 


Pro Cys Leu Glu Pro Cys Cys Pro Thr Ser Ala Cys Phe His Tyr Pro 
225                 230                 235                 240 


Lys Tyr Phe Gln Ser Gln Val His Val Glu Val Pro Lys Ser His Trp 
                245                 250                 255     


Ser Cys Gly Leu Cys Cys Arg Ser Arg Lys Lys Gly Pro Ile Ser Gln 
            260                 265                 270         


Pro Leu Asp Cys Leu Ser Asp Gly Gln Val Met Thr Leu Pro Val Gly 
        275                 280                 285             


Gly Gly Glu Ser Leu Gly Ser Pro Glu Thr Leu Asp Val Arg Leu Gly 
    290                 295                 300                 


Phe Ser Leu Cys Pro Ala Glu Leu Glu Phe Leu Gln Lys Arg Lys Val 
305                 310                 315                 320 


Val Val Ala Lys Ala Leu Lys Gln Val Leu Gln Leu Glu Glu Asp Leu 
                325                 330                 335     


Gln Glu Asp Glu Val Pro Leu Ile Ala Ile Met Ala Thr Gly Gly Gly 
            340                 345                 350         


Thr Arg Ser Met Thr Ser Met Tyr Gly His Leu Leu Gly Leu Gln Lys 
        355                 360                 365             


Leu Asn Leu Leu Asp Cys Ala Ser Tyr Ile Thr Gly Leu Ser Gly Ala 
    370                 375                 380                 


Thr Trp Thr Met Ala Thr Leu Tyr Arg Asp Pro Asp Trp Ser Ser Lys 
385                 390                 395                 400 


Asn Leu Glu Pro Ala Ile Phe Glu Ala Arg Arg His Val Val Lys Asp 
                405                 410                 415     


Lys Leu Pro Ser Leu Phe Pro Asp Gln Leu Arg Lys Phe Gln Glu Glu 
            420                 425                 430         


Leu Arg Gln Arg Ser Gln Glu Gly Tyr Arg Val Thr Phe Thr Asp Phe 
        435                 440                 445             


Trp Gly Leu Leu Ile Glu Thr Cys Leu Gly Asp Glu Arg Asn Glu Cys 
    450                 455                 460                 


Lys Leu Ser Asp Gln Arg Ala Ala Leu Ser Cys Gly Gln Asn Pro Leu 
465                 470                 475                 480 


Pro Ile Tyr Leu Thr Ile Asn Val Lys Asp Asp Val Ser Asn Gln Asp 
                485                 490                 495     


Phe Arg Glu Trp Phe Glu Phe Ser Pro Tyr Glu Val Gly Leu Gln Lys 
            500                 505                 510         


Tyr Gly Ala Phe Ile Pro Ser Glu Leu Phe Gly Ser Glu Phe Phe Met 
        515                 520                 525             


Gly Arg Leu Val Lys Arg Ile Pro Glu Ser Arg Ile Cys Tyr Met Leu 
    530                 535                 540                 


Gly Leu Trp Ser Ser Ile Phe Ser Leu Asn Leu Leu Asp Ala Trp Asn 
545                 550                 555                 560 


Leu Ser His Thr Ser Glu Glu Phe Phe His Arg Trp Thr Arg Glu Lys 
                565                 570                 575     


Val Gln Asp Ile Glu Asp Glu Pro Ile Leu Pro Glu Ile Pro Lys Cys 
            580                 585                 590         


Asp Ala Asn Ile Leu Glu Thr Thr Val Val Ile Pro Gly Ser Trp Leu 
        595                 600                 605             


Ser Asn Ser Phe Arg Glu Ile Leu Thr His Arg Ser Phe Val Ser Glu 
    610                 615                 620                 


Phe His Asn Phe Leu Ser Gly Leu Gln Leu His Thr Asn Tyr Leu Gln 
625                 630                 635                 640 


Asn Gly Gln Phe Ser Arg Trp Lys Asp Thr Val Leu Asp Gly Phe Pro 
                645                 650                 655     


Asn Gln Leu Thr Glu Ser Ala Asn His Leu Cys Leu Leu Asp Thr Ala 
            660                 665                 670         


Phe Phe Val Asn Ser Ser Tyr Pro Pro Leu Leu Arg Pro Glu Arg Lys 
        675                 680                 685             


Ala Asp Leu Ile Ile His Leu Asn Tyr Cys Ala Gly Ser Gln Thr Lys 
    690                 695                 700                 


Pro Leu Lys Gln Thr Cys Glu Tyr Cys Thr Val Gln Asn Ile Pro Phe 
705                 710                 715                 720 


Pro Lys Tyr Glu Leu Pro Asp Glu Asn Glu Asn Leu Lys Glu Cys Tyr 
                725                 730                 735     


Leu Met Glu Asn Pro Gln Glu Pro Asp Ala Pro Ile Val Thr Phe Phe 
            740                 745                 750         


Pro Leu Ile Asn Asp Thr Phe Arg Lys Tyr Lys Ala Pro Gly Val Glu 
        755                 760                 765             


Arg Ser Pro Glu Glu Leu Glu Gln Gly Gln Val Asp Ile Tyr Gly Pro 
    770                 775                 780                 


Lys Thr Pro Tyr Ala Thr Lys Glu Leu Thr Tyr Thr Glu Ala Thr Phe 
785                 790                 795                 800 


Asp Lys Leu Val Lys Leu Ser Glu Tyr Asn Ile Leu Asn Asn Lys Asp 
                805                 810                 815     


Thr Leu Leu Gln Ala Leu Arg Leu Ala Val Glu Lys Lys Lys Arg Leu 
            820                 825                 830         


Lys Gly Gln Cys Pro Ser 
        835             


<210>  53
<211>  875
<212>  PRT
<213>  Mus musculus

<400>  53

Met Gln Ser Ile Pro His Ser Asp Glu Ala Asp Val Ala Gly Met Thr 
1               5                   10                  15      


His Ala Ser Glu Gly His His Gly Leu Gly Thr Ser Met Leu Val Pro 
            20                  25                  30          


Lys Asn Pro Gln Gly Glu Glu Asp Ser Lys Leu Gly Arg Asn Cys Ser 
        35                  40                  45              


Gly Phe Glu Asp Ala Gln Asp Pro Gln Thr Ala Val Pro Ser Ser Pro 
    50                  55                  60                  


Leu Leu Ser Met Ala Ser Cys Ser Ser Gln Glu Gly Ser Ser Pro Cys 
65                  70                  75                  80  


His Leu Leu Thr Val Arg Ile Ile Gly Met Lys Asn Val Arg Gln Ala 
                85                  90                  95      


Asp Ile Leu Ser Gln Thr Asp Cys Phe Val Thr Leu Trp Leu Pro Thr 
            100                 105                 110         


Ala Ser Gln Lys Lys Leu Lys Thr Arg Thr Ile Ser Asn Cys Leu His 
        115                 120                 125             


Pro Glu Trp Asp Glu Ser Phe Thr Phe Gln Ile Gln Thr Gln Val Lys 
    130                 135                 140                 


Asn Val Leu Glu Leu Ser Val Cys Asp Glu Asp Thr Leu Thr Gln Asn 
145                 150                 155                 160 


Asp His Leu Leu Thr Val Leu Tyr Asp Leu Ser Lys Leu Cys Leu Arg 
                165                 170                 175     


Asn Lys Thr His Val Lys Phe Pro Leu Asn Pro Glu Gly Met Glu Glu 
            180                 185                 190         


Leu Glu Val Glu Phe Leu Leu Glu Glu Asn Phe Ser Ser Ser Glu Thr 
        195                 200                 205             


Leu Ile Thr Asn Gly Val Leu Val Ser Arg Gln Val Ser Cys Leu Glu 
    210                 215                 220                 


Val His Ala Glu Ser Arg Arg Pro Arg Lys Arg Lys Lys Asn Lys Asp 
225                 230                 235                 240 


Leu Leu Val Met Val Thr Asp Ser Phe Glu Asn Thr Gln Arg Val Pro 
                245                 250                 255     


Pro Cys Gln Glu Pro Cys Tyr Pro Asn Ser Ala Cys Phe His Tyr Pro 
            260                 265                 270         


Lys Tyr Ser Gln Pro Gln Leu Tyr Ala Glu Ala Pro Lys Ser His Cys 
        275                 280                 285             


Asn Phe Arg Leu Cys Cys Cys Gly Thr His Arg Asn Asp Pro Val Cys 
    290                 295                 300                 


Gln Pro Leu Asn Cys Leu Ser Asp Gly Gln Val Thr Thr Leu Pro Val 
305                 310                 315                 320 


Gly Glu Asn Tyr Glu Leu His Met Lys Ser Ser Pro Cys Ser Asp Thr 
                325                 330                 335     


Leu Asp Val Arg Leu Gly Phe Ser Leu Cys Gln Glu Glu Val Glu Phe 
            340                 345                 350         


Val Gln Lys Arg Lys Met Val Val Ala Lys Thr Leu Ser Gln Met Leu 
        355                 360                 365             


Gln Leu Glu Glu Gly Leu His Glu Asp Glu Val Pro Ile Ile Ala Ile 
    370                 375                 380                 


Met Ala Thr Gly Gly Gly Thr Arg Ser Met Val Ser Leu Tyr Gly His 
385                 390                 395                 400 


Leu Leu Gly Leu Gln Lys Leu Asn Phe Leu Asp Ala Ser Thr Tyr Ile 
                405                 410                 415     


Thr Gly Leu Ser Gly Ala Thr Trp Thr Met Ala Thr Leu Tyr Ser Asp 
            420                 425                 430         


Pro Glu Trp Ser Ser Lys Asn Leu Glu Thr Val Val Phe Glu Ala Arg 
        435                 440                 445             


Arg His Val Val Lys Asp Lys Met Pro Ala Leu Phe Pro Asp Gln Leu 
    450                 455                 460                 


Tyr Lys Trp Arg Glu Asp Leu Gln Lys His Ser Gln Glu Gly Tyr Lys 
465                 470                 475                 480 


Thr Thr Phe Thr Asp Phe Trp Gly Lys Leu Ile Glu Tyr Ser Leu Gly 
                485                 490                 495     


Asp Lys Lys Asn Glu Cys Lys Leu Ser Asp Gln Arg Ala Ala Leu Cys 
            500                 505                 510         


Arg Gly Gln Asn Pro Leu Pro Ile Tyr Leu Thr Ile Asn Val Lys Asp 
        515                 520                 525             


Asp Val Ser Asn Gln Asp Phe Arg Glu Trp Phe Glu Phe Ser Pro Tyr 
    530                 535                 540                 


Glu Val Gly Met Gln Lys Tyr Gly Ala Phe Ile Pro Ser Glu Leu Phe 
545                 550                 555                 560 


Gly Ser Glu Phe Phe Met Gly Arg Leu Met Lys Arg Ile Pro Glu Pro 
                565                 570                 575     


Glu Met Cys Tyr Met Leu Gly Leu Trp Ser Ser Ile Phe Ser Leu Asn 
            580                 585                 590         


Leu Leu Asp Ala Trp Asn Leu Ser His Thr Ser Glu Glu Phe Phe Tyr 
        595                 600                 605             


Arg Trp Thr Arg Glu Arg Leu His Asp Ile Glu Asp Asp Pro Ile Leu 
    610                 615                 620                 


Pro Glu Ile Pro Arg Cys Asp Asp Asn Pro Leu Glu Thr Thr Val Val 
625                 630                 635                 640 


Ile Pro Thr Thr Trp Leu Ser Asn Thr Phe Arg Glu Ile Leu Thr Arg 
                645                 650                 655     


Arg Pro Phe Val Ser Glu Phe His Asn Phe Leu Tyr Gly Met Gln Leu 
            660                 665                 670         


His Thr Asp Tyr Leu Gln Asn Arg Gln Phe Ser Met Trp Lys Asp Thr 
        675                 680                 685             


Val Leu Asp Thr Phe Pro Asn Gln Leu Thr Gln Phe Ala Lys His Leu 
    690                 695                 700                 


Asn Leu Leu Asp Thr Ala Phe Phe Val Asn Ser Ser Tyr Ala Pro Leu 
705                 710                 715                 720 


Leu Arg Pro Glu Arg Lys Val Asp Leu Ile Ile His Leu Asn Tyr Cys 
                725                 730                 735     


Ala Gly Ser Gln Thr Lys Pro Leu Lys Gln Thr Cys Glu Tyr Cys Thr 
            740                 745                 750         


Glu Gln Lys Ile Pro Phe Pro Ser Phe Ser Ile Leu Glu Asp Asp Asn 
        755                 760                 765             


Ser Leu Lys Glu Cys Tyr Val Met Glu Asn Pro Gln Glu Pro Asp Ala 
    770                 775                 780                 


Pro Ile Val Ala Tyr Phe Pro Leu Ile Ser Asp Thr Phe Gln Lys Tyr 
785                 790                 795                 800 


Lys Ala Pro Gly Val Glu Arg Ser Pro Asp Glu Leu Glu Leu Gly Gln 
                805                 810                 815     


Leu Asn Ile Tyr Gly Pro Lys Ser Pro Tyr Ala Thr Lys Glu Leu Thr 
            820                 825                 830         


Tyr Thr Glu Ala Ala Phe Asp Lys Leu Val Lys Leu Ser Glu Tyr Asn 
        835                 840                 845             


Ile Leu Asn Asn Arg Asp Lys Leu Ile Gln Ala Leu Arg Leu Ala Met 
    850                 855                 860                 


Glu Lys Lys Arg Met Arg Ser Gln Cys Pro Ser 
865                 870                 875 


<210>  54
<211>  786
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  54

Met Ser Ile Asn Leu Thr Ile Asp Ile Cys Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Asn Leu Cys Gly Lys His Arg Ser Lys Gln Leu His Leu Val 
            20                  25                  30          


Cys Ser Pro Asn His Cys Trp Lys Ile Arg His Val Ser Leu Gln Arg 
        35                  40                  45              


Gly Leu His Pro His Lys Val Arg Cys Lys Trp Thr Lys Ser Glu Thr 
    50                  55                  60                  


His Ser Cys Ser Lys His Tyr Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Ser Ile Arg Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Ser Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Glu Ser Ile Lys Gln Ala Ile Arg Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Thr Glu Lys Ser Pro Val Pro Glu Gly Arg Asn His 
                165                 170                 175     


Ile Ile Asp Lys Glu Asp Asp Ile Gly Lys Gln Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Gly Asn Ile Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Ala Glu Lys Met Ser Gln Asp 
    210                 215                 220                 


Lys Glu Asn Ser His Phe Gln Glu Lys Ser Glu Leu Glu Gly Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Ser Ser Ser Leu Asp Pro Gly Ile Leu Thr Ser 
                245                 250                 255     


Gln Ala Asp Lys Pro Asp Pro Lys Ser Ser Ala Gly Thr Met Asp Lys 
            260                 265                 270         


Ala Thr Ser Pro Ser Gly Thr Pro Glu Ser Leu Pro Ile Ser Thr Lys 
        275                 280                 285             


Gln Ser Ile Ala Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala 
    290                 295                 300                 


Leu Val Gly Gly Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp 
305                 310                 315                 320 


Ser Lys Ser Gln Ala Glu Glu Gln Glu Glu Pro Ala Lys Ser Glu Pro 
                325                 330                 335     


Ala Gly Ser Lys Asp Lys Thr Val Glu Glu Lys Lys His Leu Ser Leu 
            340                 345                 350         


Gln Arg Glu Lys Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg 
        355                 360                 365             


Ala Leu Val Gln Ala Leu Arg Arg Thr Ala Asp Pro Lys Leu Cys Ile 
    370                 375                 380                 


Thr Arg Val Glu Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly 
385                 390                 395                 400 


Lys Gly Val Ala Val Lys Glu Arg Leu Ile Pro Cys Leu Leu Arg Leu 
                405                 410                 415     


Arg Gln Met Lys Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu 
            420                 425                 430         


Ala Leu Ile Gly Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile 
        435                 440                 445             


Leu Thr Ile Asp Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr 
    450                 455                 460                 


Leu Arg Lys Leu Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe 
465                 470                 475                 480 


Asp Tyr Ile Cys Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu 
                485                 490                 495     


Gly Leu Phe His Leu Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys 
            500                 505                 510         


Leu Gly Ser Asp Ile Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys 
        515                 520                 525             


Met Ser Trp Ser His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Lys Ile 
    530                 535                 540                 


Leu Lys Glu Arg Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn 
545                 550                 555                 560 


Pro Met Cys Pro Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly 
                565                 570                 575     


Ser Thr Pro Lys Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly 
            580                 585                 590         


Ser Gln Ser His Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala 
        595                 600                 605             


Ile Arg Ala Ser Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu 
    610                 615                 620                 


Gly Asn Asp Leu His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser 
625                 630                 635                 640 


Ala Leu Ala Met His Glu Cys Lys Cys Leu Trp Pro Asp Ala Pro Leu 
                645                 650                 655     


Glu Cys Ile Val Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg 
            660                 665                 670         


Asn Asn Thr Thr Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile 
        675                 680                 685             


Asn Ser Ala Thr Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu 
    690                 695                 700                 


Leu Pro Pro Asp Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn 
705                 710                 715                 720 


Ile Pro Leu Asp Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu 
                725                 730                 735     


Glu Gly Ser Lys Tyr Ile Glu Arg Asn Glu His Lys Met Lys Lys Val 
            740                 745                 750         


Ala Lys Ile Leu Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp 
        755                 760                 765             


Trp Ile Lys Leu Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser 
    770                 775                 780                 


Lys Leu 
785     


<210>  55
<211>  782
<212>  PRT
<213>  Canis familiaris

<400>  55

Met Gly Asp His Ala Arg Leu Thr Arg Asp Ser Ile Phe Phe Gln Thr 
1               5                   10                  15      


Glu Gly Ala Gly Gly Gly Ala Ser Ser Pro Ala Pro Gln Lys Met Gln 
            20                  25                  30          


Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn Leu Phe 
        35                  40                  45              


Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr Thr Ser 
    50                  55                  60                  


Ser Ala Arg Val Arg Asp Glu Gly Gln Leu Ile Leu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Asn Arg Thr Trp Asp Cys Ile Leu Val Asn Pro Arg Asn Ser Gln 
                85                  90                  95      


Ser Gly Phe Arg Leu Phe Gln Leu Glu Thr Glu Ala Asp Ala Leu Val 
            100                 105                 110         


Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu Ser Ser 
        115                 120                 125             


Lys His Val Leu His Thr Glu Val Leu Gln Gln Leu Thr Asp Leu Ile 
    130                 135                 140                 


Arg Ser His Pro Ser Trp Ser Ala Ala His Leu Ala Val Glu Leu Gly 
145                 150                 155                 160 


Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala Asn Asn 
                165                 170                 175     


Arg Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys 
            180                 185                 190         


Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Ala Gln 
        195                 200                 205             


Met Asp Val Thr Asp Asn Asn Gly Glu Thr Ala Phe His Tyr Ala Val 
    210                 215                 220                 


Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Lys Asn Ala Ser 
225                 230                 235                 240 


Ala Gly Leu Asn Arg Val Asn Asn Gln Gly Gln Thr Pro Leu His Leu 
                245                 250                 255     


Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys 
            260                 265                 270         


Asn Ala Arg Cys Asn Ile Met Gly Pro Thr Gly Tyr Pro Ile His Thr 
        275                 280                 285             


Ala Met Lys Phe Cys His Lys Gly Cys Ala Glu Met Ile Ile Ser Met 
    290                 295                 300                 


Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro 
305                 310                 315                 320 


Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys Arg 
                325                 330                 335     


Gly Cys Asp Val Asn Ser Thr Ser Cys Val Gly Asn Thr Ala Leu His 
            340                 345                 350         


Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu Leu Thr 
        355                 360                 365             


Tyr Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr Pro Leu 
    370                 375                 380                 


His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala Leu Ile 
385                 390                 395                 400 


Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro 
                405                 410                 415     


Ala Ser Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Ile Val Gln 
            420                 425                 430         


Ile Ser Arg Ser Arg Lys Pro Ala Phe Ile Leu Ser Ser Met Arg Asp 
        435                 440                 445             


Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly Gly Val 
    450                 455                 460                 


Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala Ser 
465                 470                 475                 480 


Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser Thr 
                485                 490                 495     


Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala Tyr 
            500                 505                 510         


Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly Ser 
        515                 520                 525             


Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu Phe 
    530                 535                 540                 


Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val Met Leu 
545                 550                 555                 560 


Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe Arg 
                565                 570                 575     


Asn Tyr Glu Ala Pro Glu Ser Val Arg Glu Pro Arg Phe Ser Gln Asn 
            580                 585                 590         


Ile Asn Leu Lys Pro Pro Thr Gln Pro Ser Asp Gln Leu Val Trp Arg 
        595                 600                 605             


Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn Gly 
    610                 615                 620                 


Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp Ala 
625                 630                 635                 640 


Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys Gly Gln 
                645                 650                 655     


Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr Gly 
            660                 665                 670         


Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg Pro Ser 
        675                 680                 685             


Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu Gly 
    690                 695                 700                 


Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val Asp 
705                 710                 715                 720 


Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg Leu 
                725                 730                 735     


Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser Asp Thr 
            740                 745                 750         


Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu His 
        755                 760                 765             


Arg Glu Gln Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
    770                 775                 780         


<210>  56
<211>  1450
<212>  PRT
<213>  Rattus norvegicus

<400>  56

Met Glu Ser Trp Pro Gly Val Ser Leu Val Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gln Gly Pro Ser Gln Ile His Gly Ser Ser Gly Glu Asn 
            20                  25                  30          


Thr Ser Gln Pro Gln Gln Val Phe Arg Thr Leu Lys Asn Phe Ser Phe 
        35                  40                  45              


Pro Cys Lys Pro Lys Lys Leu Glu Leu Ser Val Leu Ser Lys Ser Val 
    50                  55                  60                  


His Ser Leu Arg Pro Ser Asp Ile Lys Leu Val Ala Ala Ile Gly Asn 
65                  70                  75                  80  


Leu Glu Thr Pro Pro Ala Pro Gly Ser Gly Val Val Asn Met Glu Lys 
                85                  90                  95      


Pro Gln Ser Leu Glu Ser Glu Leu Gln Asn Val Cys Ile Gly Ile Met 
            100                 105                 110         


Thr Ala Leu Ser Asp Ile Ile Arg His Phe Asn Pro Ser Val Leu Met 
        115                 120                 125             


Pro Thr Cys Ser Pro Gly Lys Gly Thr Ala Gly His Thr Thr Ile Ala 
    130                 135                 140                 


Glu Asp Leu Trp Ile Gln Ala Lys Glu Leu Val Arg His Leu Lys Asp 
145                 150                 155                 160 


Asn Pro Glu Leu Asp Phe Glu Lys Asp Trp Lys Leu Ile Thr Val Leu 
                165                 170                 175     


Phe Ser Asn Thr Ser Gln Cys His Leu Cys Ser Ser Asp Gln Gln Lys 
            180                 185                 190         


Arg His Leu Met Lys His Met Glu Met Leu Ser Gly Val Leu Asp Tyr 
        195                 200                 205             


Leu His Arg Glu Val Pro Arg Ala Phe Val Asn Leu Val Asp Leu Ser 
    210                 215                 220                 


Glu Val Leu Thr Met Ala Gln Gln His Gln Glu Thr Gly Phe Ser Pro 
225                 230                 235                 240 


Ala Pro Glu Ile Cys Lys Cys Ser Glu Glu Ile Thr Lys Leu Ser Lys 
                245                 250                 255     


Ala Val Met Gln Trp Ser Tyr Gln Glu Ala Trp Glu Asp Leu Leu Ala 
            260                 265                 270         


Ser Ser Lys Phe Asn Lys His Glu Thr Phe Ala Val Val Phe Gln Ser 
        275                 280                 285             


Phe Phe Ser Glu Val Glu Leu Pro Leu Glu Arg Pro Ser Pro Gln Asp 
    290                 295                 300                 


Ser Thr Thr Leu Ala Leu Arg Ile Trp Asn Ser Met Met Glu Pro Val 
305                 310                 315                 320 


Gly Arg Lys Asp Gly Thr Leu Asn Glu Ala Glu Arg Lys Thr Met Lys 
                325                 330                 335     


Cys Pro Ser Gln Glu Ser Pro Tyr Leu Phe Thr Tyr Arg Asn Ser Asn 
            340                 345                 350         


Tyr Gln Ala Arg Gln Leu Lys Pro Ile Gly Lys Phe Gln Met Lys Glu 
        355                 360                 365             


Gly Thr Lys Phe Thr Cys Pro Asp Lys Asp Pro Ser Asp Ser Ile Pro 
    370                 375                 380                 


Thr Thr Val His Arg Leu Arg Pro Ala Asp Ile Lys Val Ile Gly Ala 
385                 390                 395                 400 


Met Gly Asp Ser Leu Thr Ala Gly Asn Gly Ala Gly Ser Ser Pro Gly 
                405                 410                 415     


Asn Val Leu Asp Val Leu Thr Gln Tyr Arg Gly Leu Ser Trp Ser Val 
            420                 425                 430         


Gly Gly Asp Glu Thr Ile Glu Thr Val Thr Thr Leu Ala Asn Ile Leu 
        435                 440                 445             


Arg Glu Phe Asn Pro Ser Leu Lys Gly Phe Ser Val Gly Thr Gly Lys 
    450                 455                 460                 


Glu Asn Thr Pro Arg Ala Ser Phe Asn Gln Ala Val Ala Gly Ala Lys 
465                 470                 475                 480 


Ser Asp Gly Leu Ala Ala Gln Ala Lys Lys Leu Val Ser Leu Met Lys 
                485                 490                 495     


Asp Asp Lys Thr Ile Asn Phe Gln Glu Asp Trp Lys Ile Ile Thr Val 
            500                 505                 510         


Phe Ile Gly Gly Asn Asp Leu Cys Gly Ser Cys Asn Asn Leu Ala Arg 
        515                 520                 525             


Phe Ser Pro Gln Thr Phe Thr Asp Asn Ile Lys Thr Ala Leu Asp Ile 
    530                 535                 540                 


Leu His Ala Glu Val Pro Arg Ala Phe Val Asn Met Val Ser Val Ile 
545                 550                 555                 560 


Glu Ile Thr Pro Leu Arg Glu Leu Phe Asn Glu Pro Lys Val Ser Cys 
                565                 570                 575     


Pro Arg Met Ile Leu Arg Ser Leu Cys Pro Cys Val Leu Asn Leu Gly 
            580                 585                 590         


Glu Asn Ser Ala Glu Leu Ala Gln Leu Val Glu Arg Asn Arg Gln Tyr 
        595                 600                 605             


Gln Glu Glu Thr Gly Lys Leu Ile Glu Ser Gly Arg Tyr Asp Thr Arg 
    610                 615                 620                 


Asp Asp Phe Thr Val Val Leu Gln Pro Met Phe Glu Asn Val Val Met 
625                 630                 635                 640 


Pro Arg Thr Leu Glu Gly Leu Pro Asp Ser Ser Phe Phe Ala Pro Asp 
                645                 650                 655     


Cys Phe His Phe Asn Val Lys Thr His Ala Arg Ser Ala Ile Ala Leu 
            660                 665                 670         


Trp Lys Asn Met Leu Glu Pro Val Gly Arg Lys Thr Arg His Gln Asn 
        675                 680                 685             


Phe Glu Ile Lys Val Pro Ile Met Cys Pro Asn Gln Thr Ser Pro Phe 
    690                 695                 700                 


Leu Ser Thr Thr Lys Asn Ser Asn Leu Gly His Gly Thr Ser Met Ser 
705                 710                 715                 720 


Cys Glu Glu Lys Ala Pro Ser Ala Ser Pro Pro Thr Ser Val His Thr 
                725                 730                 735     


Leu Arg Pro Ala Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser Val 
            740                 745                 750         


Thr Ala Gly Asn Gly Ile Ser Ser Gln Glu Gly Asp Leu Ala Asp Val 
        755                 760                 765             


Thr Thr Gln Tyr Arg Gly Leu Ser Tyr Ser Ala Gly Gly Asp Lys Phe 
    770                 775                 780                 


Leu Glu Asn Val Thr Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn Gly 
785                 790                 795                 800 


Asn Leu Thr Gly Tyr Ser Val Gly Thr Gly Asp Val Asn Ser Ala Ser 
                805                 810                 815     


Ala Phe Leu Asn Gln Ala Val Pro Gly Ala Lys Ala Glu Asn Leu Ala 
            820                 825                 830         


Ser Gln Val Gln Thr Leu Ile Gln Lys Met Lys Asn Asp Thr Arg Val 
        835                 840                 845             


Asn Phe His Gln Asp Trp Lys Val Ile Thr Val Met Ile Gly Ala Ser 
    850                 855                 860                 


Asp Leu Cys Asp Phe Cys Lys Asp Ser Asn Arg Tyr Ser Ala Ala Asn 
865                 870                 875                 880 


Phe Ser Asp His Leu Arg Asn Ala Leu Asp Ile Leu His Lys Glu Val 
                885                 890                 895     


Pro Arg Ala Leu Val Asn Leu Val Asp Phe Met Asn Pro Ser Ile Ile 
            900                 905                 910         


Arg Gln Val Phe Leu Lys Asn Pro Asp Lys Cys Pro Val Asn Gln Thr 
        915                 920                 925             


Ser Val Leu Cys Asn Cys Val Leu Thr Pro Gly Glu Asp Ser His Glu 
    930                 935                 940                 


Leu Ala Arg Leu Glu Ala Phe Thr Lys Ser Tyr Gln Ser Ser Met Leu 
945                 950                 955                 960 


Gln Leu Val Glu Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Ser Val 
                965                 970                 975     


Val Leu Gln Pro Phe Leu Phe Asn Ile Arg Leu Pro Ile Leu Glu Asn 
            980                 985                 990         


Gly Asn Pro Asp Thr Ser Phe Phe  Ala Pro Asp Cys Ile  Leu Leu Ser 
        995                 1000                 1005             


Gln Lys  Phe His Thr Gln Leu  Ala Arg Ala Leu Trp  Ala Asn Met 
    1010                 1015                 1020             


Leu Glu  Pro Leu Gly Lys Lys  Met Asp Thr Leu Asp  Pro Lys Glu 
    1025                 1030                 1035             


Leu Ile  Ala Leu Ala Cys Pro  Thr Lys Asp Lys Pro  Phe Leu Arg 
    1040                 1045                 1050             


Thr Phe  Arg Asn Ser Asn Tyr  Thr Tyr Pro Ile Lys  Pro Ala Ile 
    1055                 1060                 1065             


Glu Asn  Trp Gly Ser Asp Phe  Leu Cys Thr Glu Gln  Ser Pro Ser 
    1070                 1075                 1080             


Ser Lys  Val Pro Thr Ser Val  His Glu Leu Arg Pro  Ser Asp Ile 
    1085                 1090                 1095             


Lys Val  Val Ala Ala Met Gly  Asp Phe Leu Thr Thr  Ala Thr Gly 
    1100                 1105                 1110             


Ala Arg  Pro Ser Glu Ser Ser  Ser Leu Asp Thr Pro  Trp Arg Gly 
    1115                 1120                 1125             


Leu Ser  Trp Ser Ile Gly Gly  Asp Gly Thr Leu Glu  Thr His Thr 
    1130                 1135                 1140             


Thr Leu  Pro Asn Ile Leu Lys  Lys Phe Asn Pro Ser  Ile Leu Gly 
    1145                 1150                 1155             


Phe Ser  Thr Gly Thr Leu Glu  Asn Thr Ala Gly Leu  Asn Val Ala 
    1160                 1165                 1170             


Glu Glu  Gly Ala Arg Ala Gln  Asp Met Pro Ala Gln  Ala Gln Ala 
    1175                 1180                 1185             


Leu Val  Lys Lys Met Lys Ser  Thr Pro Thr Ile Asn  Ile Gln Glu 
    1190                 1195                 1200             


Asp Trp  Lys Leu Ile Thr Leu  Leu Ile Gly Asn Asn  Asp Leu Cys 
    1205                 1210                 1215             


Leu Tyr  Cys Glu Asp Pro Glu  Asn Tyr Ser Thr Arg  Glu Tyr Val 
    1220                 1225                 1230             


Lys Tyr  Ile Gln His Ala Leu  Asp Ile Phe Tyr Glu  Glu Leu Pro 
    1235                 1240                 1245             


Arg Val  Phe Ile Asn Val Val  Glu Val Met Glu Leu  Ser Gly Leu 
    1250                 1255                 1260             


Leu His  Asp Gln Gly Gly Lys  Cys Ala Met Pro Leu  Ala Val Gln 
    1265                 1270                 1275             


Lys Asn  Cys Ser Cys Leu Lys  Arg Ser Gln Asn Leu  Met Ala Met 
    1280                 1285                 1290             


Gln Glu  Leu Lys Lys Val Asn  Gly Asn Leu Gln Ser  Ala Leu Ser 
    1295                 1300                 1305             


Glu Leu  Ser Tyr Trp His Arg  Tyr Met Gln Arg Glu  Asp Phe Ala 
    1310                 1315                 1320             


Val Thr  Val Gln Pro Phe Phe  Arg Asn Thr Phe Val  Pro Leu Asp 
    1325                 1330                 1335             


Glu Arg  Gly Gly Leu Asp Leu  Thr Phe Phe Ser Glu  Asp Cys Phe 
    1340                 1345                 1350             


His Phe  Ser Val Arg Gly His  Ala Glu Met Ala Ile  Ala Leu Trp 
    1355                 1360                 1365             


Asn Asn  Met Leu Glu Pro Val  Gly Lys Lys Thr Thr  Ser Asn Asn 
    1370                 1375                 1380             


Phe Thr  Tyr Asn Arg Thr Lys  Leu Lys Cys Pro Ser  Pro Glu Asn 
    1385                 1390                 1395             


Pro Phe  Leu Tyr Thr Val Arg  Asn Ser Gln Ile Leu  Leu Asp Lys 
    1400                 1405                 1410             


Ala Lys  Glu Asn Ser Asn Thr  Leu Tyr Trp Ala Val  Pro Val Ala 
    1415                 1420                 1425             


Ala Val  Gly Gly Leu Val Val  Gly Ile Leu Gly Met  Met Leu Trp 
    1430                 1435                 1440             


Arg Thr  Val Arg Leu Val Gln  
    1445                 1450 


<210>  57
<211>  146
<212>  PRT
<213>  Sus scrofa

<400>  57

Met Lys Phe Leu Val Leu Ala Val Leu Leu Thr Val Gly Ala Ala Gln 
1               5                   10                  15      


Glu Gly Ile Ser Ser Arg Ala Leu Trp Gln Phe Arg Ser Met Ile Lys 
            20                  25                  30          


Cys Ala Ile Pro Gly Ser His Pro Leu Met Asp Phe Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Arg Cys Cys Glu Thr His Asp Asn Cys Tyr Arg Asp Ala Lys Asn Leu 
65                  70                  75                  80  


Asp Ser Cys Lys Phe Leu Val Asp Asn Pro Tyr Thr Glu Ser Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Asn Thr Glu Ile Thr Cys Asn Ser Lys Asn Asn Ala 
            100                 105                 110         


Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Ala Pro Tyr Asn Lys Glu His Lys Asn Leu Asp Thr Lys Lys 
    130                 135                 140                 


Tyr Cys 
145     


<210>  58
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


<210>  59
<211>  752
<212>  PRT
<213>  Rattus norvegicus

<400>  59

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Thr Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Pro Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Ile Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu Asn Ile Lys Glu Asn Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Lys Ser Glu Gly Leu Tyr Ser Thr Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


Gln Asn Arg Met Ser Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Ser 
305                 310                 315                 320 


Ala Ala Arg Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Thr Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Asn Lys Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Ala Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ala Gln Gly Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Glu Arg Glu Tyr Gln Asn Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Val His Arg Met Leu Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Arg Asp Phe Ser Pro 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Thr Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Val Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Leu 
                645                 650                 655     


Arg Glu Thr Lys Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met Tyr Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Asp Ala Ile Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Lys Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Thr Ala Glu Ser Ile 
            740                 745                 750         


<210>  60
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Val Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu His Ile Arg Glu Ser Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Asn Ser Glu Gly Leu His Ser Ala Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
305                 310                 315                 320 


Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Ser Arg Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Thr Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ser His Glu Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Gly Ser Asp Tyr Gln Ser Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Ile His Arg Met Ile Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Ser Asp Phe Ala Thr 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Met Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Pro 
                645                 650                 655     


Arg Glu Thr Glu Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Glu Ala Met Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Arg Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Lys Ala 
            740                 745                 


<210>  61
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn 
545                 550                 555                 560 


Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  62
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  63
<211>  807
<212>  PRT
<213>  Rattus norvegicus

<400>  63

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Ala Asp Tyr 
            20                  25                  30          


Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Ala Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Leu Ile Thr Arg Lys 
385                 390                 395                 400 


Ala Leu Leu Thr Leu Leu Lys Thr Val Gly Ala Asp Tyr His Phe Pro 
                405                 410                 415     


Phe Ile Gln Gly Val Ser Thr Glu Gln Ser Ser Ala Ala Gly Pro His 
            420                 425                 430         


Pro Phe Phe Ser Leu Asp Arg Thr Gln Pro Pro Thr Ile Ser Leu Asn 
        435                 440                 445             


Asn Leu Glu Leu Gln Asp Leu Met Pro Val Ser Arg Ala Arg Lys Pro 
    450                 455                 460                 


Ala Phe Ile Leu Ser Ser Met Arg Asp Glu Lys Arg Ser His Asp His 
465                 470                 475                 480 


Leu Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val Ile Ile Gln 
                485                 490                 495     


Leu Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu 
            500                 505                 510         


Phe Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala 
        515                 520                 525             


Ile Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Val Tyr Phe Arg 
    530                 535                 540                 


Met Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro 
545                 550                 555                 560 


Leu Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr 
                565                 570                 575     


Asp Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg 
            580                 585                 590         


Gln Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Ala 
        595                 600                 605             


Val Arg Glu Pro Arg Cys Thr Pro Asn Ile Asn Leu Lys Pro Pro Thr 
    610                 615                 620                 


Gln Pro Ala Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala 
625                 630                 635                 640 


Ala Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu 
                645                 650                 655     


Leu Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr 
            660                 665                 670         


Asn Gln Asp Met Ile Arg Lys Gly Gln Gly Asn Lys Val Lys Lys Leu 
        675                 680                 685             


Ser Ile Val Val Ser Leu Gly Thr Gly Lys Ser Pro Gln Val Pro Val 
    690                 695                 700                 


Thr Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys 
705                 710                 715                 720 


Thr Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys 
                725                 730                 735     


Thr Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu 
            740                 745                 750         


Met Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Ser Asp 
        755                 760                 765             


Ile Met Leu Asp Glu Val Ser Asp Ala Val Leu Val Asn Ala Leu Trp 
    770                 775                 780                 


Glu Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu 
785                 790                 795                 800 


Val Gln Leu Leu Leu Ser Pro 
                805         


<210>  64
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  65
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Gly Ser Ser Glu Val Ser Ile Ile Pro Gly Leu Gln Lys Glu Glu 
1               5                   10                  15      


Lys Ala Ala Val Glu Arg Arg Arg Leu His Val Leu Lys Ala Leu Lys 
            20                  25                  30          


Lys Leu Arg Ile Glu Ala Asp Glu Ala Pro Val Val Ala Val Leu Gly 
        35                  40                  45              


Ser Gly Gly Gly Leu Arg Ala His Ile Ala Cys Leu Gly Val Leu Ser 
    50                  55                  60                  


Glu Met Lys Glu Gln Gly Leu Leu Asp Ala Val Thr Tyr Leu Ala Gly 
65                  70                  75                  80  


Val Ser Gly Ser Thr Trp Ala Ile Ser Ser Leu Tyr Thr Asn Asp Gly 
                85                  90                  95      


Asp Met Glu Ala Leu Glu Ala Asp Leu Lys His Arg Phe Thr Arg Gln 
            100                 105                 110         


Glu Trp Asp Leu Ala Lys Ser Leu Gln Lys Thr Ile Gln Ala Ala Arg 
        115                 120                 125             


Ser Glu Asn Tyr Ser Leu Thr Asp Phe Trp Ala Tyr Met Val Ile Ser 
    130                 135                 140                 


Lys Gln Thr Arg Glu Leu Pro Glu Ser His Leu Ser Asn Met Lys Lys 
145                 150                 155                 160 


Pro Val Glu Glu Gly Thr Leu Pro Tyr Pro Ile Phe Ala Ala Ile Asp 
                165                 170                 175     


Asn Asp Leu Gln Pro Ser Trp Gln Glu Ala Arg Ala Pro Glu Thr Trp 
            180                 185                 190         


Phe Glu Phe Thr Pro His His Ala Gly Phe Ser Ala Leu Gly Ala Phe 
        195                 200                 205             


Val Ser Ile Thr His Phe Gly Ser Lys Phe Lys Lys Gly Arg Leu Val 
    210                 215                 220                 


Arg Thr His Pro Glu Arg Asp Leu Thr Phe Leu Arg Gly Leu Trp Gly 
225                 230                 235                 240 


Ser Ala Leu Gly Asn Thr Glu Val Ile Arg Glu Tyr Ile Phe Asp Gln 
                245                 250                 255     


Leu Arg Asn Leu Thr Leu Lys Gly Leu Trp Arg Arg Ala Val Ala Asn 
            260                 265                 270         


Ala Lys Ser Ile Gly His Leu Ile Phe Ala Arg Leu Leu Arg Leu Gln 
        275                 280                 285             


Glu Ser Ser Gln Gly Glu His Pro Pro Pro Glu Asp Glu Gly Gly Glu 
    290                 295                 300                 


Pro Glu His Thr Trp Leu Thr Glu Met Leu Glu Asn Trp Thr Arg Thr 
305                 310                 315                 320 


Ser Leu Glu Lys Gln Glu Gln Pro His Glu Asp Pro Glu Arg Lys Gly 
                325                 330                 335     


Ser Leu Ser Asn Leu Met Asp Phe Val Lys Lys Thr Gly Ile Cys Ala 
            340                 345                 350         


Ser Lys Trp Glu Trp Gly Thr Thr His Asn Phe Leu Tyr Lys His Gly 
        355                 360                 365             


Gly Ile Arg Asp Lys Ile Met Ser Ser Arg Lys His Leu His Leu Val 
    370                 375                 380                 


Asp Ala Gly Leu Ala Ile Asn Thr Pro Phe Pro Leu Val Leu Pro Pro 
385                 390                 395                 400 


Thr Arg Glu Val His Leu Ile Leu Ser Phe Asp Phe Ser Ala Gly Asp 
                405                 410                 415     


Pro Phe Glu Thr Ile Arg Ala Thr Thr Asp Tyr Cys Arg Arg His Lys 
            420                 425                 430         


Ile Pro Phe Pro Gln Val Glu Glu Ala Glu Leu Asp Leu Trp Ser Lys 
        435                 440                 445             


Ala Pro Ala Ser Cys Tyr Ile Leu Lys Gly Glu Thr Gly Pro Val Val 
    450                 455                 460                 


Ile His Phe Pro Leu Phe Asn Ile Asp Ala Cys Gly Gly Asp Ile Glu 
465                 470                 475                 480 


Ala Trp Ser Asp Thr Tyr Asp Thr Phe Lys Leu Ala Asp Thr Tyr Thr 
                485                 490                 495     


Leu Asp Val Val Val Leu Leu Leu Ala Leu Ala Lys Lys Asn Val Arg 
            500                 505                 510         


Glu Asn Lys Lys Lys Ile Leu Arg Glu Leu Met Asn Val Ala Gly Leu 
        515                 520                 525             


Tyr Tyr Pro Lys Asp Ser Ala Arg Ser Cys Cys Leu Ala 
    530                 535                 540     


<210>  66
<211>  119
<212>  PRT
<213>  Sus scrofa

<400>  66

Ala Leu Phe Gln Phe Arg Ser Met Ile Lys Cys Ala Ile Pro Gly Ser 
1               5                   10                  15      


His Pro Leu Met Asp Phe Asn Asn Tyr Gly Cys Tyr Cys Gly Trp Gly 
            20                  25                  30          


Gly Ser Gly Thr Pro Val Asp Glu Leu Asp Arg Cys Cys Glu Thr His 
        35                  40                  45              


Asp Asn Cys Tyr Arg Asp Ala Lys Asn Leu Ser Gly Cys Tyr Pro Tyr 
    50                  55                  60                  


Thr Glu Ser Tyr Ser Tyr Ser Cys Ser Asn Thr Glu Ile Thr Cys Asn 
65                  70                  75                  80  


Ser Lys Asn Asn Ala Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn 
                85                  90                  95      


Ala Ala Ile Cys Phe Ser Lys Ala Pro Tyr Asn Lys Glu His Lys Asn 
            100                 105                 110         


Leu Asp Thr Lys Lys Tyr Cys 
        115                 


<210>  67
<211>  119
<212>  PRT
<213>  Sus scrofa

<400>  67

Ala Leu Phe Gln Phe Arg Ser Met Ile Lys Cys Ala Ile Pro Gly Ser 
1               5                   10                  15      


His Pro Leu Met Asp Phe Asn Asn Tyr Gly Cys Tyr Cys Gly Trp Gly 
            20                  25                  30          


Gly Ser Gly Thr Pro Val Asp Glu Leu Asp Arg Cys Cys Glu Thr His 
        35                  40                  45              


Asp Asn Cys Tyr Arg Asp Ala Lys Asn Leu Ser Gly Cys Tyr Pro Tyr 
    50                  55                  60                  


Thr Glu Ser Tyr Ser Tyr Ser Cys Ser Asn Thr Glu Ile Thr Cys Asn 
65                  70                  75                  80  


Ser Lys Asn Asn Ala Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn 
                85                  90                  95      


Ala Ala Ile Cys Phe Ser Lys Ala Pro Tyr Asn Lys Glu His Lys Asn 
            100                 105                 110         


Leu Asp Thr Lys Lys Tyr Cys 
        115                 


<210>  68
<211>  1463
<212>  PRT
<213>  Cavia porcellus

<400>  68

Met Gly Leu Gln Pro Gly Val Leu Leu Val Gly Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gln Gly Ile Thr Gln Ile His Thr Ser Ser Gly Lys Ser Thr Leu Glu 
            20                  25                  30          


Gly Gln Leu Trp Pro Glu Thr Lys Lys Asn Phe Pro Phe Ser Cys Ser 
        35                  40                  45              


Pro Lys Lys Leu Gly Leu Asn Met Pro Ser Glu Ser Val His Thr Leu 
    50                  55                  60                  


Thr Pro Ala Asp Ile Lys Leu Ile Ala Ala Ile Gly Asp Met Glu Thr 
65                  70                  75                  80  


Pro Pro Asp Ser Gly Ala Val Asn Leu Asp Thr Ser Glu Arg Thr Glu 
                85                  90                  95      


Lys Glu Pro Trp Arg Gly Cys Met Gly Met Met Thr Val Leu Ser Asp 
            100                 105                 110         


Ile Ile Ser His Phe Asn Pro Ser Val Leu Leu Pro Thr Cys Pro Pro 
        115                 120                 125             


Trp Arg Ser Ala Ala Val Arg Gly Gly Val Glu Glu Leu Arg Thr Gln 
    130                 135                 140                 


Ala Glu Glu Leu Val Ser Ser Leu Lys Lys Asn Pro Gln Leu Asp Phe 
145                 150                 155                 160 


Gln Gln Asp Trp Lys Leu Ile Asn Val Phe Phe Ser Asn Ala Ser Leu 
                165                 170                 175     


Cys Tyr Leu Cys Pro Ser Ala His Glu Asn Gly Pro Leu Met Ser Asn 
            180                 185                 190         


Met Asp Lys Leu Ala Gly Ile Leu His Tyr Leu His Gln Glu Val Pro 
        195                 200                 205             


Arg Ala Phe Val Asn Leu Val Asp Leu Phe Glu Val Val Ala Met Pro 
    210                 215                 220                 


Arg Trp His Gln Gly Thr Met Leu Ser Arg Pro Ser Pro Glu Ala Cys 
225                 230                 235                 240 


Gly Cys Ser Gly Glu Thr Ser Lys Leu Asp Thr Val Val Met Gln Trp 
                245                 250                 255     


Ser Tyr Gln Glu Thr Trp Asp Ser Leu Leu Ala Ser Ser Ser Phe Asn 
            260                 265                 270         


Asp Gln Glu Ser Phe Ala Val Val Phe Gln Pro Phe Phe Tyr Glu Val 
        275                 280                 285             


Ser Ser Pro Val Glu Glu Pro Pro Ser Gln Asp Pro Thr Thr Leu Ala 
    290                 295                 300                 


Leu Ser Leu Trp Asn Asn Met Met Lys Pro Val Gly Gln Lys Asp Glu 
305                 310                 315                 320 


Pro Phe Ser Thr Ile Glu Arg Arg Pro Met Lys Cys Pro Ser Gln Glu 
                325                 330                 335     


Ser Pro Tyr Leu Phe Thr Tyr Arg Asn Ser Asn Tyr Gln Ser Arg Leu 
            340                 345                 350         


Leu Lys Arg Gln Arg Gln His Lys Glu Arg Glu Gly Thr Glu Ile Arg 
        355                 360                 365             


Cys Pro Asp Lys Asp Pro Ser Asp Ser Thr Pro Thr Ser Val His Arg 
    370                 375                 380                 


Leu Lys Pro Ala Asp Ile Lys Val Ile Gly Ala Leu Gly Asp Ser Leu 
385                 390                 395                 400 


Thr Ala Gly Asn Gly Ala Gly Ser Arg Pro Gly Asn Ile Leu Asp Val 
                405                 410                 415     


Leu Thr Glu Tyr Arg Gly Leu Ser Trp Ser Ile Gly Ala Asp His Asn 
            420                 425                 430         


Ile Ser Ser Val Thr Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn Pro 
        435                 440                 445             


Ser Leu Lys Gly Phe Ser Thr Gly Thr Gly Lys Ala Asn Ser Val Gly 
    450                 455                 460                 


Ala Phe Phe Asn Gln Ala Val Ala Gly Ala Arg Ala Gly Asp Leu Ile 
465                 470                 475                 480 


Pro Gln Ala Arg Thr Leu Val Asp Leu Met Lys Asn His Thr Ser Ile 
                485                 490                 495     


Asn Phe Glu Glu Asp Trp Lys Ile Ile Thr Val Phe Ile Gly Gly Asn 
            500                 505                 510         


Asp Leu Cys Asp Phe Cys Ser Asp Pro Val Thr Asn Ser Pro Glu Asn 
        515                 520                 525             


Phe Thr Asp Asn Ile Arg Gln Ala Leu Asp Ile Leu His Ala Glu Val 
    530                 535                 540                 


Pro Arg Ala Phe Val Asn Met Val Lys Val Leu Gln Ile Val Asn Leu 
545                 550                 555                 560 


Arg Glu Leu Tyr Lys Asp Ser Arg Val Ser Cys Pro Arg Leu Ile Leu 
                565                 570                 575     


Arg Asn Leu Cys Arg Cys Val Leu Leu Pro Asp Asp Asn Ser Thr Glu 
            580                 585                 590         


Leu Glu Ser Leu Ile Asp Ile Asn Lys Lys Tyr Gln Glu Arg Thr His 
        595                 600                 605             


Gln Leu Ile Glu Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Thr Val 
    610                 615                 620                 


Val Leu Gln Pro Phe Phe Glu Lys Val Asp Ile Pro Lys Thr Ser Glu 
625                 630                 635                 640 


Gly Leu Pro Asp Asn Thr Ser Phe Ala Pro Asp Cys Phe His Phe Ser 
                645                 650                 655     


Ser Lys Thr His Ala Arg Ala Ala Ser Ala Leu Trp Lys Asn Met Leu 
            660                 665                 670         


Glu Pro Val Gly Gln Lys Thr Thr Gln Asn Asn Phe Glu Asn Ser Ile 
        675                 680                 685             


Asp Ile Ile Cys Pro Asn Gln Ala Phe Pro Tyr Leu Ser Thr Tyr Lys 
    690                 695                 700                 


Asn Gly Ile Glu Gly His Gly Thr Trp Leu Thr Cys Arg Glu Arg Thr 
705                 710                 715                 720 


Pro Ser Ala Ser Pro Pro Thr Ser Val His Ala Leu Arg Pro Ala Asp 
                725                 730                 735     


Val Arg Val Val Ala Ala Leu Gly Asp Ser Leu Thr Ala Gly Ser Gly 
            740                 745                 750         


Ile Gly Ser Lys Pro Gly Asp Leu Ala Asp Val Ile Thr Gln Tyr Arg 
        755                 760                 765             


Gly Leu Ser Tyr Ser Ser Gly Gly Asp Gly Ser Leu Met Asn Val Thr 
    770                 775                 780                 


Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn Ser Asn Leu Thr Gly Tyr 
785                 790                 795                 800 


Ala Val Gly Thr Gly Asp Ala Ser Asn Thr Asn Ala Phe Leu Asn Gln 
                805                 810                 815     


Ala Val Pro Gly Ala Lys Ala Glu Glu Leu Met Ser Gln Val Lys Thr 
            820                 825                 830         


Leu Val Gln Lys Met Lys Asp Asp Pro Arg Ile Asn Phe His Glu Asp 
        835                 840                 845             


Trp Lys Val Ile Thr Val Leu Ile Gly Thr Asn Asp Leu Cys Asn His 
    850                 855                 860                 


Cys Thr Asp Leu Asp Leu Tyr Ser Ser Ala Asn Phe Phe Asn His Leu 
865                 870                 875                 880 


Leu Asn Ala Leu Asp Ile Leu His Arg Glu Val Pro Arg Ala Leu Val 
                885                 890                 895     


Asn Leu Val Asp Phe Met Asn Pro Ser Ile Met Arg Gln Val Phe Leu 
            900                 905                 910         


Gly Asn Pro Asp Lys Cys Pro Val Gln Gln Ala Ser Ile Leu Cys Asn 
        915                 920                 925             


Cys Val Leu Ser Leu Arg Glu Asn Ser Tyr Glu Leu Ala Arg Met Asp 
    930                 935                 940                 


Ala Leu Thr Arg Ala Tyr Gln Ser Ser Met Arg Glu Leu Val Glu Ser 
945                 950                 955                 960 


Gly Arg Tyr Asp Thr Arg Glu Asp Phe Ser Val Val Leu Gln Pro Phe 
                965                 970                 975     


Phe Leu Asn Ile Arg Leu Pro Ile Leu Glu Asp Gly Arg Pro Asp Thr 
            980                 985                 990         


Ser Phe Phe Ala Pro Asp Cys Ile  Asn Pro Gly Gln Lys  Phe His Ser 
        995                 1000                 1005             


Gln Leu  Ser Arg Ala Leu Trp  Val Asn Met Leu Glu  Pro Val Gly 
    1010                 1015                 1020             


Ser Lys  Thr Asp Thr Leu Asp  Leu Thr Ala Asp Ile  Ser Leu Pro 
    1025                 1030                 1035             


Cys Pro  Thr Gln Glu Glu Pro  Phe Leu Arg Thr Pro  Gln Asn Ser 
    1040                 1045                 1050             


Asp Tyr  Thr Tyr Pro Thr Lys  Pro Ala Ile Glu Asn  Trp Gly Ser 
    1055                 1060                 1065             


Asp Phe  Leu Cys Thr Glu Trp  Lys Pro Ser Asn Ser  Val Pro Thr 
    1070                 1075                 1080             


Ser Val  His Lys Leu Gln Pro  Ala Asp Ile Lys Val  Val Ala Ala 
    1085                 1090                 1095             


Leu Gly  Asp Ser Leu Thr Thr  Ala Val Gly Ala Arg  Ala Ser Asn 
    1100                 1105                 1110             


Ser Ser  Asp Leu Leu Met Ser  Trp Arg Gly Leu Ser  Trp Ser Ile 
    1115                 1120                 1125             


Gly Gly  Asp Gly Ala Leu Glu  Thr His Thr Thr Leu  Pro Asn Ile 
    1130                 1135                 1140             


Leu Lys  Lys Phe Asn Pro Ser  Ile Phe Gly Phe Ser  Thr Gly Thr 
    1145                 1150                 1155             


Leu Glu  Glu Thr Ala Gly Phe  Asn Val Ala Val Glu  Glu Ala Arg 
    1160                 1165                 1170             


Ala Arg  Asp Met Pro Ala Gln  Ala Arg Asp Leu Val  Glu Arg Met 
    1175                 1180                 1185             


Lys Ala  Ser Thr Glu Ile Asn  Leu Glu Met Asp Trp  Lys Leu Ile 
    1190                 1195                 1200             


Thr Leu  Phe Ile Gly Ser Asn  Asp Leu Cys His Tyr  Cys Asp Asn 
    1205                 1210                 1215             


Pro Glu  Asn His Ser Ala Glu  Glu Tyr Val Gln His  Ile Arg Gln 
    1220                 1225                 1230             


Ala Leu  Asp Ile Leu Tyr Glu  Glu Leu Pro Arg Ala  Phe Ile Asn 
    1235                 1240                 1245             


Val Val  Asp Ile Ile Met Glu  Leu Ala Gly Leu His  Gln Gly Gln 
    1250                 1255                 1260             


Gly Gly  His Cys Thr Ala Leu  Leu Pro Ala Gln Ser  Thr Cys Ser 
    1265                 1270                 1275             


Cys Leu  Arg His Phe Pro Ser  Ser Pro Val Ile Gln  Glu Leu Lys 
    1280                 1285                 1290             


Lys Val  Thr Trp Asn Leu Gln  Ser Asp Met Ser Arg  Leu Ser Tyr 
    1295                 1300                 1305             


Gln Glu  Lys Tyr Thr Gln Arg  Glu Asp Phe Ala Val  Val Val Gln 
    1310                 1315                 1320             


Pro Phe  Phe Gln Asn Thr Leu  Ile Pro Leu Asp Lys  Leu Gly Ser 
    1325                 1330                 1335             


Thr Asp  Pro Thr Phe Phe Ser  Glu Asp Cys Leu His  Phe Ser Glu 
    1340                 1345                 1350             


Arg Gly  His Ala Glu Met Ala  Ile Ala Leu Trp Asn  Asn Met Leu 
    1355                 1360                 1365             


Glu Pro  Val Gly His Lys Thr  Thr Phe Asn Asn Phe  Thr Tyr Asn 
    1370                 1375                 1380             


Arg Thr  Lys Leu Lys Cys Pro  Ser Thr Glu Ser Pro  Tyr Leu Tyr 
    1385                 1390                 1395             


Thr Leu  Gln Asn Ser Leu Ser  Leu Pro Val Gln Thr  Glu Lys Ala 
    1400                 1405                 1410             


Ser Gly  Val Ala Pro Gly Ile  Val Ser Ala Ala Ala  Ala Gly Gly 
    1415                 1420                 1425             


Leu Leu  Val Gly Leu Ile Val  Gly Ile Leu Ala Val  Ser Leu Trp 
    1430                 1435                 1440             


Ser Ser  Phe Arg Arg Arg Gln  Lys Lys Ser Pro Pro  Glu Ser Val 
    1445                 1450                 1455             


Pro Val  Ala Asn Phe 
    1460             


<210>  69
<211>  748
<212>  PRT
<213>  Mus musculus

<400>  69

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Thr Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Pro Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Ile Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu Asn Ile Lys Glu Asn Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Lys Ser Glu Gly Leu Tyr Ser Thr Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Ile 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


Gln Asn Arg Met Ser Met Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
305                 310                 315                 320 


Ala Ala Arg Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Asn Lys Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Ala Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ala Gln Gly Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Glu Ala Glu Lys Glu Tyr Gln Ser Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Val His Arg Met Leu Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Arg Asp Phe Ser Ser 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro Asp 
        515                 520                 525             


Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys Ile 
    530                 535                 540                 


His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu Ile 
545                 550                 555                 560 


Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe Ser 
                565                 570                 575     


Ala Arg Pro Ser Asp Thr Ser Pro Pro Phe Lys Glu Leu Leu Leu Ala 
            580                 585                 590         


Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp Pro 
        595                 600                 605             


Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys Pro 
    610                 615                 620                 


Lys Asn Pro Asp Val Glu Lys Asp Cys Pro Thr Ile Ile His Phe Val 
625                 630                 635                 640 


Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Leu Arg 
                645                 650                 655     


Glu Thr Lys Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp Asp 
            660                 665                 670         


Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln Ala 
        675                 680                 685             


Phe Lys Arg Leu His Asp Leu Met Tyr Phe Asn Thr Leu Asn Asn Ile 
    690                 695                 700                 


Asp Val Ile Lys Asp Ala Ile Val Glu Ser Ile Glu Tyr Arg Arg Gln 
705                 710                 715                 720 


Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg Lys 
                725                 730                 735     


Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Thr Val 
            740                 745             


<210>  70
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Gly Pro Leu Pro Val Cys Leu Pro Ile Met Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ser Leu Leu Leu Leu Leu Leu Leu Pro Gly Pro Gly Ser Gly Glu 
            20                  25                  30          


Ala Ser Arg Ile Leu Arg Val His Arg Arg Gly Ile Leu Glu Leu Ala 
        35                  40                  45              


Gly Thr Val Gly Cys Val Gly Pro Arg Thr Pro Ile Ala Tyr Met Lys 
    50                  55                  60                  


Tyr Gly Cys Phe Cys Gly Leu Gly Gly His Gly Gln Pro Arg Asp Ala 
65                  70                  75                  80  


Ile Asp Trp Cys Cys His Gly His Asp Cys Cys Tyr Thr Arg Ala Glu 
                85                  90                  95      


Glu Ala Gly Cys Ser Pro Lys Thr Glu Arg Tyr Ser Trp Gln Cys Val 
            100                 105                 110         


Asn Gln Ser Val Leu Cys Gly Pro Ala Glu Asn Lys Cys Gln Glu Leu 
        115                 120                 125             


Leu Cys Lys Cys Asp Gln Glu Ile Ala Asn Cys Leu Ala Gln Thr Glu 
    130                 135                 140                 


Tyr Asn Leu Lys Tyr Leu Phe Tyr Pro Gln Phe Leu Cys Glu Pro Asp 
145                 150                 155                 160 


Ser Pro Lys Cys Asp 
                165 


<210>  71
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Pro Gly Gly Leu Leu Leu Gly Asp Val Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Val Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Arg Asn Arg Glu Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Val Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asp Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  72
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  72

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  73
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Gly Val Gln Ala Gly Leu Phe Gly Met Leu Gly Phe Leu Gly Val 
1               5                   10                  15      


Ala Leu Gly Gly Ser Pro Ala Leu Arg Trp Tyr Arg Thr Ser Cys His 
            20                  25                  30          


Leu Thr Lys Ala Val Pro Gly Asn Pro Leu Gly Tyr Leu Ser Phe Leu 
        35                  40                  45              


Ala Lys Asp Ala Gln Gly Leu Ala Leu Ile His Ala Arg Trp Asp Ala 
    50                  55                  60                  


His Arg Arg Leu Gln Ser Cys Ser Trp Glu Asp Glu Pro Glu Leu Thr 
65                  70                  75                  80  


Ala Ala Tyr Gly Ala Leu Cys Ala His Glu Thr Ala Trp Gly Ser Phe 
                85                  90                  95      


Ile His Thr Pro Gly Pro Glu Leu Gln Arg Ala Leu Ala Thr Leu Gln 
            100                 105                 110         


Ser Gln Trp Glu Ala Cys Arg Ala Leu Glu Glu Ser Pro Ala Gly Ala 
        115                 120                 125             


Arg Lys Lys Arg Ala Ala Gly Gln Ser Gly Val Pro Gly Gly Gly His 
    130                 135                 140                 


Gln Arg Glu Lys Arg Gly Trp Thr Met Pro Gly Thr Leu Trp Cys Gly 
145                 150                 155                 160 


Val Gly Asp Ser Ala Gly Asn Ser Ser Glu Leu Gly Val Phe Gln Gly 
                165                 170                 175     


Pro Asp Leu Cys Cys Arg Glu His Asp Arg Cys Pro Gln Asn Ile Ser 
            180                 185                 190         


Pro Leu Gln Tyr Asn Tyr Gly Ile Arg Asn Tyr Arg Phe His Thr Ile 
        195                 200                 205             


Ser His Cys Asp Cys Asp Thr Arg Phe Gln Gln Cys Leu Gln Asn Gln 
    210                 215                 220                 


His Asp Ser Ile Ser Asp Ile Val Gly Val Ala Phe Phe Asn Val Leu 
225                 230                 235                 240 


Glu Ile Pro Cys Phe Val Leu Glu Glu Gln Glu Ala Cys Val Ala Trp 
                245                 250                 255     


Tyr Trp Trp Gly Gly Cys Arg Met Tyr Gly Thr Val Pro Leu Ala Arg 
            260                 265                 270         


Leu Gln Pro Arg Thr Phe Tyr Asn Ala Ser Trp Ser Ser Arg Ala Thr 
        275                 280                 285             


Ser Pro Thr Pro Ser Ser Arg Ser Pro Ala Pro Pro Lys Pro Arg Gln 
    290                 295                 300                 


Lys Gln His Leu Arg Lys Gly Pro Pro His Gln Lys Gly Ser Lys Arg 
305                 310                 315                 320 


Pro Ser Lys Ala Asn Thr Thr Ala Leu Gln Asp Pro Met Val Ser Pro 
                325                 330                 335     


Arg Leu Asp Val Ala Pro Thr Gly Leu Gln Gly Pro Gln Gly Gly Leu 
            340                 345                 350         


Lys Pro Gln Gly Ala Arg Trp Val Cys Arg Ser Phe Arg Arg His Leu 
        355                 360                 365             


Asp Gln Cys Glu His Gln Ile Gly Pro Arg Glu Ile Glu Phe Gln Leu 
    370                 375                 380                 


Leu Asn Ser Ala Gln Glu Pro Leu Phe His Cys Asn Cys Thr Arg Arg 
385                 390                 395                 400 


Leu Ala Arg Phe Leu Arg Leu His Ser Pro Pro Glu Val Thr Asn Met 
                405                 410                 415     


Leu Trp Glu Leu Leu Gly Thr Thr Cys Phe Lys Leu Ala Pro Pro Leu 
            420                 425                 430         


Asp Cys Val Glu Gly Lys Asn Cys Ser Arg Asp Pro Arg Ala Ile Arg 
        435                 440                 445             


Val Ser Ala Arg His Leu Arg Arg Leu Gln Gln Arg Arg His Gln Leu 
    450                 455                 460                 


Gln Asp Lys Gly Thr Asp Glu Arg Gln Pro Trp Pro Ser Glu Pro Leu 
465                 470                 475                 480 


Arg Gly Pro Met Ser Phe Tyr Asn Gln Cys Leu Gln Leu Thr Gln Ala 
                485                 490                 495     


Ala Arg Arg Pro Asp Arg Gln Gln Lys Ser Trp Ser Gln 
            500                 505                 


<210>  74
<211>  1487
<212>  PRT
<213>  Mus musculus

<400>  74

Met Val Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu Gln Gln Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ile His Gln Gly Ile Ala Gln Asp Leu Thr His Ile 
            20                  25                  30          


Gln Glu Pro Ser Leu Glu Trp Arg Asp Lys Gly Ile Phe Ile Ile Gln 
        35                  40                  45              


Ser Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser Val Leu Thr 
    50                  55                  60                  


Leu Glu Asn Cys Lys Gln Pro Asn Glu His Met Leu Trp Lys Trp Val 
65                  70                  75                  80  


Ser Asp Asp His Leu Phe Asn Val Gly Gly Ser Gly Cys Leu Gly Leu 
                85                  90                  95      


Asn Ile Ser Ala Leu Glu Gln Pro Leu Lys Leu Tyr Glu Cys Asp Ser 
            100                 105                 110         


Thr Leu Ile Ser Leu Arg Trp His Cys Asp Arg Lys Met Ile Glu Gly 
        115                 120                 125             


Pro Leu Gln Tyr Lys Val Gln Val Lys Ser Asp Asn Thr Val Val Ala 
    130                 135                 140                 


Arg Lys Gln Ile His Arg Trp Ile Ala Tyr Thr Ser Ser Gly Gly Asp 
145                 150                 155                 160 


Ile Cys Glu His Pro Ser Arg Asp Leu Tyr Thr Leu Lys Gly Asn Ala 
                165                 170                 175     


His Gly Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly His Trp His 
            180                 185                 190         


His Asp Cys Ile Arg Glu Gly Gln Lys Glu His Leu Leu Trp Cys Ala 
        195                 200                 205             


Thr Thr Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe Cys Pro Asp 
    210                 215                 220                 


Pro Thr Ser Met Lys Val Phe Cys Asp Ala Thr Trp Gln Arg Asn Gly 
225                 230                 235                 240 


Ser Ser Arg Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp 
                245                 250                 255     


Asn Gln Ala His Ser Ser Cys Leu Met Gln Gly Gly Ala Leu Leu Ser 
            260                 265                 270         


Ile Ala Asp Glu Asp Glu Glu Asp Phe Ile Arg Lys His Leu Ser Lys 
        275                 280                 285             


Val Val Lys Glu Val Trp Ile Gly Leu Asn Gln Leu Asp Glu Lys Ala 
    290                 295                 300                 


Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser 
305                 310                 315                 320 


Gln Glu Ile Thr Pro Gly Pro Phe Val Glu His His Cys Gly Thr Leu 
                325                 330                 335     


Glu Val Val Ser Ala Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu 
            340                 345                 350         


Pro Tyr Ile Cys Lys Arg Asp Leu Asn His Thr Ala Gln Gly Ile Leu 
        355                 360                 365             


Glu Lys Asp Ser Trp Lys Tyr His Ala Thr His Cys Asp Pro Asp Trp 
    370                 375                 380                 


Thr Pro Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Asp Arg Lys Ser 
385                 390                 395                 400 


Trp Leu Gly Ala Leu His Ser Cys Gln Ser Asn Asp Ser Val Leu Met 
                405                 410                 415     


Asp Val Ala Ser Leu Ala Glu Val Glu Phe Leu Val Ser Leu Leu Arg 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Ser Gly Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp Tyr Pro Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Glu Ser Asp Gly Arg Trp Lys Val Lys Asp Cys Lys 
                485                 490                 495     


Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly Gln Val Pro Ala Asp 
            500                 505                 510         


Glu Gln Ser Gly Cys Pro Ala Gly Trp Glu Arg His Gly Arg Phe Cys 
        515                 520                 525             


Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Glu Glu Ala Ser Ser Gly 
    530                 535                 540                 


Tyr Tyr Cys Ser Pro Ala Leu Leu Thr Ile Thr Ser Arg Phe Glu Gln 
545                 550                 555                 560 


Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Ala Glu Lys Asp Ser Tyr 
                565                 570                 575     


Phe Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp 
            580                 585                 590         


Lys Thr Val Gly Gln Arg Glu Pro Val Gln Tyr Thr Tyr Trp Asn Thr 
        595                 600                 605             


Arg Gln Pro Ser Asn Arg Gly Gly Cys Val Val Val Arg Gly Gly Ser 
    610                 615                 620                 


Ser Leu Gly Arg Trp Glu Val Lys Asp Cys Ser Asp Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Thr Pro Val Lys Ile Trp Glu Lys Thr Glu Leu Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu Ser Ala Thr 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Arg Arg Asn Pro Leu Asn Ala Gly Ser Trp Ala Trp Ser 
            740                 745                 750         


Asp Gly Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala Tyr Phe Glu 
        755                 760                 765             


Glu Asp Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Ser Asn Cys Ala Ser Lys His Glu Trp Ile Cys Arg Ile Pro Arg 
785                 790                 795                 800 


Asp Val Arg Pro Lys Phe Pro Asp Trp Tyr Gln Tyr Asp Ala Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His Pro Ala Glu 
            820                 825                 830         


Trp Ala Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Phe Leu 
        835                 840                 845             


Thr Ile Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Gly Leu Thr Lys Tyr Gly Val Lys Trp Trp Ile Gly Leu Glu Glu Gly 
865                 870                 875                 880 


Gly Ala Arg Asp Gln Ile Gln Trp Ser Asn Gly Ser Pro Val Ile Phe 
                885                 890                 895     


Gln Asn Trp Asp Lys Gly Arg Glu Glu Arg Val Asp Ser Gln Arg Lys 
            900                 905                 910         


Arg Cys Val Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Thr Glu Asn 
        915                 920                 925             


Cys Ser Val Pro Leu Pro Ser Ile Cys Lys Arg Val Lys Ile Trp Val 
    930                 935                 940                 


Ile Glu Lys Glu Lys Pro Pro Thr Gln Pro Gly Thr Cys Pro Lys Gly 
945                 950                 955                 960 


Trp Leu Tyr Phe Asn Tyr Lys Cys Phe Leu Val Thr Ile Pro Lys Asp 
                965                 970                 975     


Pro Arg Glu Leu Lys Thr Trp Thr Gly Ala Gln Glu Phe Cys Val Ala 
            980                 985                 990         


Lys Gly Gly Thr Leu Val Ser Ile  Lys Ser Glu Leu Glu  Gln Ala Phe 
        995                 1000                 1005             


Ile Thr  Met Asn Leu Phe Gly  Gln Thr Thr Asn Val  Trp Ile Gly 
    1010                 1015                 1020             


Leu Gln  Ser Thr Asn His Glu  Lys Trp Val Asn Gly  Lys Pro Leu 
    1025                 1030                 1035             


Val Tyr  Ser Asn Trp Ser Pro  Ser Asp Ile Ile Asn  Ile Pro Ser 
    1040                 1045                 1050             


Tyr Asn  Thr Thr Glu Phe Gln  Lys His Ile Pro Leu  Cys Ala Leu 
    1055                 1060                 1065             


Met Ser  Ser Asn Pro Asn Phe  His Phe Thr Gly Lys  Trp Tyr Phe 
    1070                 1075                 1080             


Asp Asp  Cys Gly Lys Glu Gly  Tyr Gly Phe Val Cys  Glu Lys Met 
    1085                 1090                 1095             


Gln Asp  Thr Leu Glu His His  Val Asn Val Ser Asp  Thr Ser Ala 
    1100                 1105                 1110             


Ile Pro  Ser Thr Leu Glu Tyr  Gly Asn Arg Thr Tyr  Lys Ile Ile 
    1115                 1120                 1125             


Arg Gly  Asn Met Thr Trp Tyr  Ala Ala Gly Lys Ser  Cys Arg Met 
    1130                 1135                 1140             


His Arg  Ala Glu Leu Ala Ser  Ile Pro Asp Ala Phe  His Gln Ala 
    1145                 1150                 1155             


Phe Leu  Thr Val Leu Leu Ser  Arg Leu Gly His Thr  His Trp Ile 
    1160                 1165                 1170             


Gly Leu  Ser Thr Thr Asp Asn  Gly Gln Thr Phe Asp  Trp Ser Asp 
    1175                 1180                 1185             


Gly Thr  Lys Ser Pro Phe Thr  Tyr Trp Lys Asp Glu  Glu Ser Ala 
    1190                 1195                 1200             


Phe Leu  Gly Asp Cys Ala Phe  Ala Asp Thr Asn Gly  Arg Trp His 
    1205                 1210                 1215             


Ser Thr  Ala Cys Glu Ser Phe  Leu Gln Gly Ala Ile  Cys His Val 
    1220                 1225                 1230             


Val Thr  Glu Thr Lys Ala Phe  Glu His Pro Gly Leu  Cys Ser Glu 
    1235                 1240                 1245             


Thr Ser  Val Pro Trp Ile Lys  Phe Lys Gly Asn Cys  Tyr Ser Phe 
    1250                 1255                 1260             


Ser Thr  Val Leu Asp Ser Arg  Ser Phe Glu Asp Ala  His Glu Phe 
    1265                 1270                 1275             


Cys Lys  Ser Glu Gly Ser Asn  Leu Leu Ala Ile Arg  Asp Ala Ala 
    1280                 1285                 1290             


Glu Asn  Ser Phe Leu Leu Glu  Glu Leu Leu Ala Phe  Gly Ser Ser 
    1295                 1300                 1305             


Val Gln  Met Val Trp Leu Asn  Ala Gln Phe Asp Asn  Asn Asn Lys 
    1310                 1315                 1320             


Thr Leu  Arg Trp Phe Asp Gly  Thr Pro Thr Glu Gln  Ser Asn Trp 
    1325                 1330                 1335             


Gly Leu  Arg Lys Pro Asp Met  Asp His Leu Lys Pro  His Pro Cys 
    1340                 1345                 1350             


Val Val  Leu Arg Ile Pro Glu  Gly Ile Trp His Phe  Thr Pro Cys 
    1355                 1360                 1365             


Glu Asp  Lys Lys Gly Phe Ile  Cys Lys Met Glu Ala  Gly Ile Pro 
    1370                 1375                 1380             


Ala Val  Thr Ala Gln Pro Glu  Lys Gly Leu Ser His  Ser Ile Val 
    1385                 1390                 1395             


Pro Val  Thr Val Thr Leu Thr  Leu Ile Ile Ala Leu  Gly Ile Phe 
    1400                 1405                 1410             


Met Leu  Cys Phe Trp Ile Tyr  Lys Gln Lys Ser Asp  Ile Phe Gln 
    1415                 1420                 1425             


Arg Leu  Thr Gly Ser Arg Gly  Ser Tyr Tyr Pro Thr  Leu Asn Phe 
    1430                 1435                 1440             


Ser Thr  Ala His Leu Glu Glu  Asn Ile Leu Ile Ser  Asp Leu Glu 
    1445                 1450                 1455             


Lys Asn  Thr Asn Asp Glu Glu  Val Arg Asp Ala Pro  Ala Thr Glu 
    1460                 1465                 1470             


Ser Lys  Arg Gly His Lys Gly  Arg Pro Ile Cys Ile  Ser Pro 
    1475                 1480                 1485         


<210>  75
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  76
<211>  1458
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Gly Leu Arg Pro Gly Ile Phe Leu Leu Glu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Gln Gly Thr Pro Gln Ile His Thr Ser Pro Arg Lys Ser Thr Leu 
            20                  25                  30          


Glu Gly Gln Leu Trp Pro Glu Thr Leu Lys Asn Ser Pro Phe Pro Cys 
        35                  40                  45              


Asn Pro Asn Lys Leu Gly Val Asn Met Pro Ser Lys Ser Val His Ser 
    50                  55                  60                  


Leu Lys Pro Ser Asp Ile Lys Phe Val Ala Ala Ile Gly Asn Leu Glu 
65                  70                  75                  80  


Ile Pro Pro Asp Pro Gly Thr Gly Asp Leu Glu Lys Gln Asp Trp Thr 
                85                  90                  95      


Glu Arg Pro Gln Gln Val Cys Met Gly Val Met Thr Val Leu Ser Asp 
            100                 105                 110         


Ile Ile Arg Tyr Phe Ser Pro Ser Val Pro Met Pro Val Cys His Thr 
        115                 120                 125             


Gly Lys Arg Val Ile Pro His Asp Gly Ala Glu Asp Leu Trp Ile Gln 
    130                 135                 140                 


Ala Gln Glu Leu Val Arg Asn Met Lys Glu Asn Leu Gln Leu Asp Phe 
145                 150                 155                 160 


Gln Phe Asp Trp Lys Leu Ile Asn Val Phe Phe Ser Asn Ala Ser Gln 
                165                 170                 175     


Cys Tyr Leu Cys Pro Ser Ala Gln Gln Asn Gly Leu Ala Ala Gly Gly 
            180                 185                 190         


Val Asp Glu Leu Met Gly Val Leu Asp Tyr Leu Gln Gln Glu Val Pro 
        195                 200                 205             


Arg Ala Phe Val Asn Leu Val Asp Leu Ser Glu Val Ala Glu Val Ser 
    210                 215                 220                 


Arg Gln Tyr His Gly Thr Trp Leu Ser Pro Ala Pro Glu Pro Cys Asn 
225                 230                 235                 240 


Cys Ser Glu Glu Thr Thr Arg Leu Ala Lys Val Val Met Gln Trp Ser 
                245                 250                 255     


Tyr Gln Glu Ala Trp Asn Ser Leu Leu Ala Ser Ser Arg Tyr Ser Glu 
            260                 265                 270         


Gln Glu Ser Phe Thr Val Val Phe Gln Pro Phe Phe Tyr Glu Thr Thr 
        275                 280                 285             


Pro Ser Leu His Ser Glu Asp Pro Arg Leu Gln Asp Ser Thr Thr Leu 
    290                 295                 300                 


Ala Trp His Leu Trp Asn Arg Met Met Glu Pro Ala Gly Glu Lys Asp 
305                 310                 315                 320 


Glu Pro Leu Ser Val Lys His Gly Arg Pro Met Lys Cys Pro Ser Gln 
                325                 330                 335     


Glu Ser Pro Tyr Leu Phe Ser Tyr Arg Asn Ser Asn Tyr Leu Thr Arg 
            340                 345                 350         


Leu Gln Lys Pro Gln Asp Lys Leu Glu Val Arg Glu Gly Ala Glu Ile 
        355                 360                 365             


Arg Cys Pro Asp Lys Asp Pro Ser Asp Thr Val Pro Thr Ser Val His 
    370                 375                 380                 


Arg Leu Lys Pro Ala Asp Ile Asn Val Ile Gly Ala Leu Gly Asp Ser 
385                 390                 395                 400 


Leu Thr Ala Gly Asn Gly Ala Gly Ser Thr Pro Gly Asn Val Leu Asp 
                405                 410                 415     


Val Leu Thr Gln Tyr Arg Gly Leu Ser Trp Ser Val Gly Gly Asp Glu 
            420                 425                 430         


Asn Ile Gly Thr Val Thr Thr Leu Ala Asn Ile Leu Arg Glu Phe Asn 
        435                 440                 445             


Pro Ser Leu Lys Gly Phe Ser Val Gly Thr Gly Lys Glu Thr Ser Pro 
    450                 455                 460                 


Asn Ala Phe Leu Asn Gln Ala Val Ala Gly Gly Arg Ala Glu Asp Leu 
465                 470                 475                 480 


Pro Val Gln Ala Arg Arg Leu Val Asp Leu Met Lys Asn Asp Thr Arg 
                485                 490                 495     


Ile His Phe Gln Glu Asp Trp Lys Ile Ile Thr Leu Phe Ile Gly Gly 
            500                 505                 510         


Asn Asp Leu Cys Asp Phe Cys Asn Asp Leu Val His Tyr Ser Pro Gln 
        515                 520                 525             


Asn Phe Thr Asp Asn Ile Gly Lys Ala Leu Asp Ile Leu His Ala Glu 
    530                 535                 540                 


Val Pro Arg Ala Phe Val Asn Leu Val Thr Val Leu Glu Ile Val Asn 
545                 550                 555                 560 


Leu Arg Glu Leu Tyr Gln Glu Lys Lys Val Tyr Cys Pro Arg Met Ile 
                565                 570                 575     


Leu Arg Ser Leu Cys Pro Cys Val Leu Lys Phe Asp Asp Asn Ser Thr 
            580                 585                 590         


Glu Leu Ala Thr Leu Ile Glu Phe Asn Lys Lys Phe Gln Glu Lys Thr 
        595                 600                 605             


His Gln Leu Ile Glu Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Thr 
    610                 615                 620                 


Val Val Val Gln Pro Phe Phe Glu Asn Val Asp Met Pro Lys Thr Ser 
625                 630                 635                 640 


Glu Gly Leu Pro Asp Asn Ser Phe Phe Ala Pro Asp Cys Phe His Phe 
                645                 650                 655     


Ser Ser Lys Ser His Ser Arg Ala Ala Ser Ala Leu Trp Asn Asn Met 
            660                 665                 670         


Leu Glu Pro Val Gly Gln Lys Thr Thr Arg His Lys Phe Glu Asn Lys 
        675                 680                 685             


Ile Asn Ile Thr Cys Pro Asn Gln Val Gln Pro Phe Leu Arg Thr Tyr 
    690                 695                 700                 


Lys Asn Ser Met Gln Gly His Gly Thr Trp Leu Pro Cys Arg Asp Arg 
705                 710                 715                 720 


Ala Pro Ser Ala Leu His Pro Thr Ser Val His Ala Leu Arg Pro Ala 
                725                 730                 735     


Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser Leu Thr Ala Gly Asn 
            740                 745                 750         


Gly Ile Gly Ser Lys Pro Asp Asp Leu Pro Asp Val Thr Thr Gln Tyr 
        755                 760                 765             


Arg Gly Leu Ser Tyr Ser Ala Gly Gly Asp Gly Ser Leu Glu Asn Val 
    770                 775                 780                 


Thr Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn Arg Asn Leu Thr Gly 
785                 790                 795                 800 


Tyr Ala Val Gly Thr Gly Asp Ala Asn Asp Thr Asn Ala Phe Leu Asn 
                805                 810                 815     


Gln Ala Val Pro Gly Ala Lys Ala Glu Asp Leu Met Ser Gln Val Gln 
            820                 825                 830         


Thr Leu Met Gln Lys Met Lys Asp Asp His Arg Val Asn Phe His Glu 
        835                 840                 845             


Asp Trp Lys Val Ile Thr Val Leu Ile Gly Gly Ser Asp Leu Cys Asp 
    850                 855                 860                 


Tyr Cys Thr Asp Ser Asn Leu Tyr Ser Ala Ala Asn Phe Val Asp His 
865                 870                 875                 880 


Leu Arg Asn Ala Leu Asp Val Leu His Arg Glu Val Pro Arg Val Leu 
                885                 890                 895     


Val Asn Leu Val Asp Phe Leu Asn Pro Thr Ile Met Arg Gln Val Phe 
            900                 905                 910         


Leu Gly Asn Pro Asp Lys Cys Pro Val Gln Gln Ala Ser Val Leu Cys 
        915                 920                 925             


Asn Cys Val Leu Thr Leu Arg Glu Asn Ser Gln Glu Leu Ala Arg Leu 
    930                 935                 940                 


Glu Ala Phe Ser Arg Ala Tyr Arg Ser Ser Met Arg Glu Leu Val Gly 
945                 950                 955                 960 


Ser Gly Arg Tyr Asp Thr Gln Glu Asp Phe Ser Val Val Leu Gln Pro 
                965                 970                 975     


Phe Phe Gln Asn Ile Gln Leu Pro Val Leu Ala Asp Gly Leu Pro Asp 
            980                 985                 990         


Thr Ser Phe Phe Ala Pro Asp Cys  Ile His Pro Asn Gln  Lys Phe His 
        995                 1000                 1005             


Ser Gln  Leu Ala Arg Ala Leu  Trp Thr Asn Met Leu  Glu Pro Leu 
    1010                 1015                 1020             


Gly Ser  Lys Thr Glu Thr Leu  Asp Leu Arg Ala Glu  Met Pro Ile 
    1025                 1030                 1035             


Thr Cys  Pro Thr Gln Asn Glu  Pro Phe Leu Arg Thr  Pro Arg Asn 
    1040                 1045                 1050             


Ser Asn  Tyr Thr Tyr Pro Ile  Lys Pro Ala Ile Glu  Asn Trp Gly 
    1055                 1060                 1065             


Ser Asp  Phe Leu Cys Thr Glu  Trp Lys Ala Ser Asn  Ser Val Pro 
    1070                 1075                 1080             


Thr Ser  Val His Gln Leu Arg  Pro Ala Asp Ile Lys  Val Val Ala 
    1085                 1090                 1095             


Ala Leu  Gly Asp Ser Leu Thr  Thr Ala Val Gly Ala  Arg Pro Asn 
    1100                 1105                 1110             


Asn Ser  Ser Asp Leu Pro Thr  Ser Trp Arg Gly Leu  Ser Trp Ser 
    1115                 1120                 1125             


Ile Gly  Gly Asp Gly Asn Leu  Glu Thr His Thr Thr  Leu Pro Asn 
    1130                 1135                 1140             


Ile Leu  Lys Lys Phe Asn Pro  Tyr Leu Leu Gly Phe  Ser Thr Ser 
    1145                 1150                 1155             


Thr Trp  Glu Gly Thr Ala Gly  Leu Asn Val Ala Ala  Glu Gly Ala 
    1160                 1165                 1170             


Arg Ala  Arg Asp Met Pro Ala  Gln Ala Trp Asp Leu  Val Glu Arg 
    1175                 1180                 1185             


Met Lys  Asn Ser Pro Asp Ile  Asn Leu Glu Lys Asp  Trp Lys Leu 
    1190                 1195                 1200             


Val Thr  Leu Phe Ile Gly Val  Asn Asp Leu Cys His  Tyr Cys Glu 
    1205                 1210                 1215             


Asn Pro  Glu Ala His Leu Ala  Thr Glu Tyr Val Gln  His Ile Gln 
    1220                 1225                 1230             


Gln Ala  Leu Asp Ile Leu Ser  Glu Glu Leu Pro Arg  Ala Phe Val 
    1235                 1240                 1245             


Asn Val  Val Glu Val Met Glu  Leu Ala Ser Leu Tyr  Gln Gly Gln 
    1250                 1255                 1260             


Gly Gly  Lys Cys Ala Met Leu  Ala Ala Gln Asn Asn  Cys Thr Cys 
    1265                 1270                 1275             


Leu Arg  His Ser Gln Ser Ser  Leu Glu Lys Gln Glu  Leu Lys Lys 
    1280                 1285                 1290             


Val Asn  Trp Asn Leu Gln His  Gly Ile Ser Ser Phe  Ser Tyr Trp 
    1295                 1300                 1305             


His Gln  Tyr Thr Gln Arg Glu  Asp Phe Ala Val Val  Val Gln Pro 
    1310                 1315                 1320             


Phe Phe  Gln Asn Thr Leu Thr  Pro Leu Asn Glu Arg  Gly Asp Thr 
    1325                 1330                 1335             


Asp Leu  Thr Phe Phe Ser Glu  Asp Cys Phe His Phe  Ser Asp Arg 
    1340                 1345                 1350             


Gly His  Ala Glu Met Ala Ile  Ala Leu Trp Asn Asn  Met Leu Glu 
    1355                 1360                 1365             


Pro Val  Gly Arg Lys Thr Thr  Ser Asn Asn Phe Thr  His Ser Arg 
    1370                 1375                 1380             


Ala Lys  Leu Lys Cys Pro Ser  Pro Glu Ser Pro Tyr  Leu Tyr Thr 
    1385                 1390                 1395             


Leu Arg  Asn Ser Arg Leu Leu  Pro Asp Gln Ala Glu  Glu Ala Pro 
    1400                 1405                 1410             


Glu Val  Leu Tyr Trp Ala Val  Pro Val Ala Ala Gly  Val Gly Leu 
    1415                 1420                 1425             


Val Val  Gly Ile Ile Gly Thr  Val Val Trp Arg Cys  Arg Arg Gly 
    1430                 1435                 1440             


Gly Arg  Arg Glu Asp Pro Pro  Met Ser Leu Arg Thr  Val Ala Leu 
    1445                 1450                 1455             


<210>  77
<211>  1478
<212>  PRT
<213>  Mus musculus

<400>  77

Met Glu Leu Tyr Pro Gly Val Ser Pro Val Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gln Gly Pro Ser Gln Ile His Gly Ser Ser Gly Glu Asn 
            20                  25                  30          


Thr Leu Ala Trp Gln Ser Gln Gln Val Phe Trp Thr Leu Lys Asn Phe 
        35                  40                  45              


Pro Phe Pro Cys Lys Pro Lys Lys Leu Glu Leu Ser Val Leu Ser Glu 
    50                  55                  60                  


Ser Val His Ser Leu Arg Pro Ser Asp Ile Lys Leu Val Ala Ala Ile 
65                  70                  75                  80  


Gly Asn Pro Glu Ile Pro Leu Ala Pro Gly Ser Gly Thr Ile Asn Met 
                85                  90                  95      


Glu Lys Pro Gln Ser Ile Lys Asn Gln Pro Gln Asp Val Cys Met Gly 
            100                 105                 110         


Ile Met Thr Val Leu Ser Asp Ile Ile Arg His Phe Ser Pro Ser Val 
        115                 120                 125             


Leu Met Pro Thr Cys Ser Pro Gly Lys Gly Thr Ala Val His Thr Thr 
    130                 135                 140                 


Ala Glu Asp Leu Trp Ile Gln Ala Lys Glu Leu Val Arg Arg Leu Lys 
145                 150                 155                 160 


Asp Asn Pro Gln Leu Asp Phe Glu Lys Asp Trp Lys Leu Ile Thr Val 
                165                 170                 175     


Phe Phe Ser Asn Thr Ser Gln Cys His Leu Cys Pro Ser Ala Gln Gln 
            180                 185                 190         


Lys Ser His Leu Met Arg His Met Glu Met Leu Trp Gly Val Leu Asp 
        195                 200                 205             


Tyr Leu His His Glu Val Pro Arg Ala Phe Val Asn Leu Val Asp Leu 
    210                 215                 220                 


Ser Glu Val Leu Ala Met Asp Leu Gln His Gln Glu Thr Gly Phe Ser 
225                 230                 235                 240 


Pro Ala Pro Glu Val Cys Lys Cys Thr Glu Thr Thr Thr Leu Ser Lys 
                245                 250                 255     


Ala Val Met Gln Trp Ser Tyr Gln Glu Ala Trp Glu Asp Leu Leu Ala 
            260                 265                 270         


Ser Ser Lys Phe Asn Lys His Glu Thr Phe Ala Val Val Phe Gln Pro 
        275                 280                 285             


Phe Phe Asp Glu Ile Glu Pro Pro Leu Lys Arg Ser Ser Pro Gln Asp 
    290                 295                 300                 


Pro Thr Thr Leu Ala Leu Arg Ile Trp Asn Ser Met Met Glu Pro Val 
305                 310                 315                 320 


Gly Gln Lys Asp Gly Leu Leu Asn Thr Ala Glu Arg Lys Thr Met Lys 
                325                 330                 335     


Cys Pro Ser Glu Glu Ser Pro Tyr Leu Phe Thr Tyr Lys Asn Ser Asn 
            340                 345                 350         


Tyr Gln Ala Arg Arg Leu Lys Pro Ile Thr Lys Leu Gln Met Lys Glu 
        355                 360                 365             


Gly Ser Glu Phe Thr Cys Pro Asp Lys Asn Pro Ser Asn Ser Ile Pro 
    370                 375                 380                 


Thr Thr Val His Ser Leu Arg Pro Ala Asp Ile Lys Ile Ile Gly Ala 
385                 390                 395                 400 


Leu Gly Asp Ser Leu Thr Ala Gly Asn Gly Ala Gly Ala Ser Pro Trp 
                405                 410                 415     


Asn Ile Leu Asp Val Leu Thr Glu Tyr Arg Gly Leu Ser Trp Ser Val 
            420                 425                 430         


Gly Gly Asp Glu Thr Ile Lys Thr Val Thr Thr Leu Pro Asn Ile Leu 
        435                 440                 445             


Arg Glu Phe Asn Pro Ser Leu Lys Gly Phe Ser Val Gly Thr Gly Lys 
    450                 455                 460                 


Glu Ser Thr Ser Arg Ala Ser Phe Asn Gln Ala Val Ala Gly Ala Lys 
465                 470                 475                 480 


Ser Asp Gly Leu Ala Gly Gln Ala Arg Lys Leu Val Asp Leu Met Lys 
                485                 490                 495     


Ala Asp Lys Thr Ile Asn Phe Gln Glu Asp Trp Lys Ile Ile Thr Val 
            500                 505                 510         


Phe Ile Gly Gly Asn Asp Leu Cys Ala Ser Cys Ser Asn Ser Thr Arg 
        515                 520                 525             


Phe Ser Pro Gln Asn Phe Ile Asp Asn Ile Lys Asn Ala Leu Asp Ile 
    530                 535                 540                 


Leu His Ala Glu Val Pro Arg Ala Phe Val Asn Met Ala Met Val Met 
545                 550                 555                 560 


Glu Ile Thr Pro Leu Arg Glu Leu Phe Asn Glu Pro Thr Val Ser Cys 
                565                 570                 575     


Pro Arg Asn Ile Leu Ser Arg Leu Cys Pro Cys Val Leu Gly Leu Gly 
            580                 585                 590         


Asp Asn Ser Glu Glu Leu Ser Ser Leu Val Gln Arg Asn Arg Asp Tyr 
        595                 600                 605             


Gln Lys Lys Thr Glu Glu Leu Ile Asn Ser Gly Arg Tyr Asp Thr Arg 
    610                 615                 620                 


Asp Asn Phe Thr Val Val Val Gln Pro Leu Phe Glu Asn Val Ser Met 
625                 630                 635                 640 


Pro Arg Thr Pro Glu Gly Val Pro Asp Lys Ser Phe Phe Ala Pro Asp 
                645                 650                 655     


Cys Phe His Phe Asn Ala Lys Thr His Ala Arg Ser Ala Ile Ala Leu 
            660                 665                 670         


Trp Lys Asn Met Leu Glu Pro Val Gly His Lys Thr Arg His Asn Asn 
        675                 680                 685             


Phe Glu Ile Lys Ala Pro Ile Val Cys Pro Asn Gln Ala Ser Pro Phe 
    690                 695                 700                 


Leu Ser Thr Thr Lys Asn Ser Asn Leu Gly Asn Gly Thr Trp Met Val 
705                 710                 715                 720 


Cys Glu Glu Arg Ala Pro Ser Ala Ser Pro Pro Thr Ser Val His Thr 
                725                 730                 735     


Leu Arg Pro Ala Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser Leu 
            740                 745                 750         


Thr Ala Gly Asn Gly Ile Ser Ser Gln Glu Gly Asn Leu Thr Asp Val 
        755                 760                 765             


Ser Thr Gln Tyr Arg Gly Leu Ser Tyr Ser Ala Gly Gly Asp Lys Thr 
    770                 775                 780                 


Leu Glu Asn Val Thr Thr Leu Pro Asn Ile Leu Arg Lys Phe Asn Gly 
785                 790                 795                 800 


Asn Leu Thr Gly Tyr Ser Val Gly Thr Gly Asp Ser Ser Ser Ala Asn 
                805                 810                 815     


Ala Phe Leu Asn Gln Ala Val Pro Gly Ala Lys Ala Glu Asn Leu Thr 
            820                 825                 830         


Ser Gln Val Arg Thr Leu Val Gln Lys Met Lys Ser Asp Asn Arg Val 
        835                 840                 845             


Asn Phe Asn Arg Asp Trp Lys Val Ile Thr Val Met Ile Gly Ala Ser 
    850                 855                 860                 


Asp Leu Cys Asp Phe Cys Thr Asp Ser Asn His Tyr Ser Ala Ala Asn 
865                 870                 875                 880 


Phe Phe Asp His Leu Gln Asn Ala Leu Asp Ile Leu His Lys Glu Val 
                885                 890                 895     


Pro Arg Ala Leu Val Asn Leu Val Asp Phe Ile Asn Pro Ser Ile Ile 
            900                 905                 910         


Arg Glu Val Phe Leu Lys Asn Pro Asp Lys Cys Pro Val Asn Gln Ser 
        915                 920                 925             


Ser Val Leu Cys Asn Cys Val Leu Thr Pro Arg Lys Asp Ser Tyr Glu 
    930                 935                 940                 


Leu Ala Arg Leu Glu Ala Phe Thr Lys Ser Tyr Gln Ser Ser Met Leu 
945                 950                 955                 960 


Gln Leu Val Glu Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Ser Val 
                965                 970                 975     


Val Leu Gln Pro Phe Leu Leu Asn Thr Lys Leu Pro Val Leu Glu Asn 
            980                 985                 990         


Gly Lys Pro Asp Thr Ser Phe Phe  Ala Pro Asp Cys Ile  His Leu Asn 
        995                 1000                 1005             


Gln Lys  Phe His Thr Gln Leu  Ala Arg Ala Leu Trp  Ala Asn Met 
    1010                 1015                 1020             


Leu Glu  Pro Leu Gly Lys Lys  Thr Asp Thr Leu Asp  Pro Lys Gly 
    1025                 1030                 1035             


His Ile  Ser Leu Ala Cys Pro  Thr Lys Asp Gln Pro  Phe Leu Arg 
    1040                 1045                 1050             


Thr Phe  Arg Asn Ser Asn Tyr  Lys Tyr Pro Thr Lys  Pro Ala Ile 
    1055                 1060                 1065             


Glu Asn  Trp Gly Ser Asp Phe  Leu Cys Thr Glu Lys  Ser Pro Ser 
    1070                 1075                 1080             


Ser Gln  Val Pro Thr Ser Val  His Glu Leu Arg Pro  Ala Asp Ile 
    1085                 1090                 1095             


Lys Val  Val Ala Ala Met Gly  Asp Phe Leu Thr Thr  Ala Thr Gly 
    1100                 1105                 1110             


Ala Arg  Pro Ser Gly Tyr Lys  Arg Leu Ala Thr Pro  Trp Arg Gly 
    1115                 1120                 1125             


Leu Ser  Trp Ser Ile Gly Gly  Asp Gly Lys Leu Glu  Thr His Thr 
    1130                 1135                 1140             


Thr Leu  Pro Asn Ile Leu Lys  Lys Phe Asn Pro Ser  Ile Thr Gly 
    1145                 1150                 1155             


Phe Ser  Thr Gly Thr Leu Asp  Asn Lys Ala Gly Leu  Asn Val Ala 
    1160                 1165                 1170             


Glu Glu  Gly Ala Arg Ala Gln  Asp Met Pro Ala Gln  Ala Lys Thr 
    1175                 1180                 1185             


Leu Val  Lys Lys Met Lys Ser  Thr Pro Thr Ile Asn  Leu Gln Glu 
    1190                 1195                 1200             


Asp Trp  Lys Leu Ile Thr Leu  Leu Ile Gly Asn Asn  Asp Leu Cys 
    1205                 1210                 1215             


Leu Tyr  Cys Glu Asn Pro Glu  Asp Asn Ser Thr Lys  Glu Tyr Val 
    1220                 1225                 1230             


Lys Tyr  Ile Gln Gln Ala Leu  Asp Ile Leu Tyr Glu  Glu Leu Pro 
    1235                 1240                 1245             


Arg Val  Phe Ile Asn Val Val  Glu Val Met Glu Leu  Ala Gly Leu 
    1250                 1255                 1260             


His His  Val Gln Gly Gly Lys  Cys Ala Met Pro Leu  Ala Val Gln 
    1265                 1270                 1275             


Lys Asn  Cys Ser Cys Leu Arg  His Ser Gln Asn Leu  Thr Ala Met 
    1280                 1285                 1290             


Gln Glu  Leu Lys Lys Leu Asn  Trp Asn Leu Gln Ser  Gly Ile Ser 
    1295                 1300                 1305             


Glu Leu  Ser Tyr Trp His Arg  Tyr Met Glu Arg Glu  Asp Phe Ala 
    1310                 1315                 1320             


Val Thr  Val Gln Pro Phe Phe  Arg Asn Thr Phe Ile  Pro Leu Asn 
    1325                 1330                 1335             


Glu Arg  Glu Gly Leu Asp Leu  Thr Phe Phe Ser Glu  Asp Cys Phe 
    1340                 1345                 1350             


Tyr Phe  Ser Asp Arg Gly His  Ala Glu Met Ala Ile  Ala Leu Trp 
    1355                 1360                 1365             


Asn Asn  Met Leu Glu Pro Val  Gly Trp Lys Thr Ser  Ser Asn Asn 
    1370                 1375                 1380             


Phe Ile  Tyr Asn Arg Thr Lys  Leu Lys Cys Pro Ser  Pro Glu Arg 
    1385                 1390                 1395             


Pro Phe  Leu Tyr Thr Leu Arg  Asn Ser Gln Leu Leu  Pro Asp Lys 
    1400                 1405                 1410             


Ala Glu  Glu Pro Ser Asn Ala  Leu Tyr Trp Ala Val  Pro Val Ala 
    1415                 1420                 1425             


Ala Ile  Gly Gly Leu Ala Val  Gly Ile Leu Gly Val  Met Leu Trp 
    1430                 1435                 1440             


Arg Thr  Val Lys Pro Val Gln  Gln Glu Glu Glu Glu  Glu Asp Thr 
    1445                 1450                 1455             


Leu Pro  Asn Thr Ser Val Thr  Gln Asp Ala Val Ser  Glu Lys Arg 
    1460                 1465                 1470             


Leu Lys  Ala Gly Asn 
    1475             


<210>  78
<211>  1458
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  78

Met Ala Leu Trp Pro Ser Val Phe Leu Leu Gly Leu Leu Pro Leu Leu 
1               5                   10                  15      


Gly Arg Gly Ala Asp Gln Ile Gln Thr Ser Ser Gly Lys Asn Thr Leu 
            20                  25                  30          


Glu Gly Gln Leu Trp Pro Glu Ser Leu Lys Thr Phe Pro Phe Pro Cys 
        35                  40                  45              


Asp Pro Lys Thr Leu Ala Glu Ser Val Pro Ser Glu Ser Val His Ser 
    50                  55                  60                  


Leu Arg Pro Ser Asp Ile Lys Phe Val Ala Ala Ile Gly Asn Val Glu 
65                  70                  75                  80  


Thr Ala Pro Asp Ser Gly Ala Asp Asp Leu Glu Glu Gln Asp Gly Thr 
                85                  90                  95      


Glu Lys Arg Pro Glu Gln Ala Cys Met Gly Val Val Thr Val Leu Ser 
            100                 105                 110         


Asp Ile Ile Gly Arg Phe Ser Pro Ser Ala Leu Met Pro Leu Cys Pro 
        115                 120                 125             


Glu Thr Arg Leu Val Pro Arg Gly Gly Ala Glu Asp Leu Trp Met Gln 
    130                 135                 140                 


Ala Thr Glu Leu Val Arg Ser Met Arg Glu Asn Pro Gln Leu Asp Phe 
145                 150                 155                 160 


Glu His Asp Trp Lys Leu Ile Asn Val Phe Phe Ser Asn Thr Ser Gln 
                165                 170                 175     


Cys Phe Pro Cys Pro Ser Ala Gln Gln Lys Gly Leu Val Leu Gly Gly 
            180                 185                 190         


Met Asp Lys Leu Thr Arg Thr Leu Asp Tyr Leu Gln Gln Glu Val Pro 
        195                 200                 205             


Lys Ala Phe Val Asn Leu Val Asp Leu Ser Glu Leu Ala Ala Phe Ser 
    210                 215                 220                 


Arg Trp Arg Gln Gly Ala Gln Leu Ser Pro Ala Ala Glu Pro Cys Arg 
225                 230                 235                 240 


Cys Leu Arg Glu Thr Ser Gln Leu Thr Lys Val Leu Thr Gln Trp Ser 
                245                 250                 255     


Tyr Leu Glu Ala Trp Asp Ser Leu Leu Ala Ser Ser Lys Tyr Asn Thr 
            260                 265                 270         


Gln Glu Ser Phe Ala Val Val Phe Gln Pro Phe Phe Tyr Glu Ser Ser 
        275                 280                 285             


Leu Ser Ala Leu Leu Ala Glu Pro Pro Leu Gln Asp Pro Thr Thr Leu 
    290                 295                 300                 


Ala Leu Ser Leu Trp Asn Arg Met Met Glu Pro Ile Gly Arg Lys Glu 
305                 310                 315                 320 


Glu Pro Phe Ser Glu Lys Glu Arg Lys Pro Leu Arg Cys Pro Thr Gln 
                325                 330                 335     


Glu Ser Pro Tyr Leu Phe Thr Tyr Arg Asn Ser Gly Gln Leu Thr Arg 
            340                 345                 350         


Val Ser Gln Pro Gln Gly Lys Leu Glu Val Arg Glu Gly Thr Glu Ile 
        355                 360                 365             


Arg Cys Pro Asp Lys Asp Pro Ser Asp Ser Val Pro Thr Ser Val His 
    370                 375                 380                 


Arg Leu Lys Pro Ala Asp Ile Lys Val Ile Gly Ala Met Gly Asp Ser 
385                 390                 395                 400 


Leu Thr Ala Gly Asn Gly Ala Gly Ser Gln Pro Gly Asn Ile Leu Asp 
                405                 410                 415     


Val Leu Thr Gln Tyr Arg Gly Leu Ser Trp Ser Val Gly Gly Asp Gln 
            420                 425                 430         


Asn Ile Ser Thr Val Thr Thr Leu Ala Asn Ile Leu Arg Glu Phe Asn 
        435                 440                 445             


Pro Ser Leu Gln Gly Phe Ser Val Gly Thr Gly Arg Glu Thr Thr Ser 
    450                 455                 460                 


Gln Ala Phe Phe Asn Gln Ala Val Ala Gly Ala Arg Ala Asp Gly Leu 
465                 470                 475                 480 


Ile Pro Gln Ala Gln Arg Leu Val Ala Leu Met Lys Asn Asp Thr Arg 
                485                 490                 495     


Ile Asn Phe Gln Glu Asp Trp Lys Ile Ile Thr Val Phe Ile Gly Gly 
            500                 505                 510         


Asn Asp Leu Cys Asp Phe Cys Asn Asp Pro Val Arg Tyr Ser Pro Gln 
        515                 520                 525             


Asn Phe Thr Asp Asn Ile Gly Thr Ala Leu Asp Ile Leu His Ala Glu 
    530                 535                 540                 


Ile Pro Arg Ala Phe Val Asn Leu Val Lys Val Leu Glu Ile Ser Lys 
545                 550                 555                 560 


Leu Arg Glu Leu Tyr Gln Glu Thr Lys Val Ser Cys Pro Arg Met Ile 
                565                 570                 575     


Leu Arg Ser Leu Cys Pro Cys Val Leu Lys Phe Asp Asp Asn Ser Thr 
            580                 585                 590         


Glu Ile Ala Ser Leu Ile Glu Thr Ile Lys Glu Tyr Gln Glu Arg Thr 
        595                 600                 605             


Gln Gln Leu Ile Asp Ser Gly Arg Tyr Asp Thr Arg Asp Asp Phe Thr 
    610                 615                 620                 


Val Val Leu Gln Pro Phe Phe Glu Lys Val Asn Met Pro Lys Thr Gln 
625                 630                 635                 640 


Asp Gly Leu Pro Asp Asn Ser Phe Phe Ala Pro Asp Cys Phe His Phe 
                645                 650                 655     


Ser Ser Lys Ala His Ala His Ala Ala Ser Ala Leu Trp Asn Asn Met 
            660                 665                 670         


Leu Glu Pro Val Gly Gln Lys Thr Thr His Asn Asp Phe Glu Gly Ala 
        675                 680                 685             


Val Asn Ile Thr Cys Pro Asn Gln Val Trp Pro Phe Leu Ser Thr Tyr 
    690                 695                 700                 


Lys Asn Ser Val Gln Gly Phe Gly Thr Trp Leu Pro Cys Arg Asp Arg 
705                 710                 715                 720 


Ser Pro Ser Ala Ser Pro Pro Thr Ser Val His Ala Leu Arg Pro Ala 
                725                 730                 735     


Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser Leu Thr Ala Gly Ile 
            740                 745                 750         


Gly Ile Gly Ser Lys Pro Asn Asp Leu Ser Asp Gly Thr Thr Gln Tyr 
        755                 760                 765             


Arg Gly Leu Ser Tyr Ser Ser Gly Gly Asp Gly Ser Leu Asp Asn Val 
    770                 775                 780                 


Thr Thr Leu Pro Asn Ile Leu Arg Gln Phe Asn Ser Asn Leu Met Gly 
785                 790                 795                 800 


Phe Ala Val Gly Thr Gly Asp Ala Ser Gly Thr Asn Ala Phe Phe Asn 
                805                 810                 815     


Gln Ala Val Pro Gly Ala Lys Ala Arg Asp Leu Met Ser Gln Val Gln 
            820                 825                 830         


Thr Leu Val Gln Arg Met Lys Asp Asp His Arg Val Asn Phe Gln Glu 
        835                 840                 845             


Asp Trp Lys Val Ile Thr Val Gln Ile Gly Ala Ser Asp Leu Cys Asp 
    850                 855                 860                 


Tyr Cys Thr Asp Ser Asn Leu Tyr Ser Ala Ala Asn Phe Tyr Asp His 
865                 870                 875                 880 


Leu Arg Asp Ala Leu Asp Ala Leu His Arg Glu Val Pro Arg Ala Leu 
                885                 890                 895     


Val Asn Leu Val Asp Phe Met Asn Pro Ser Val Thr Arg Gln Val Phe 
            900                 905                 910         


Leu Gly Asn Pro Asp Lys Cys Pro Val Gln Gln Ala Ser Ala Leu Cys 
        915                 920                 925             


Asn Cys Val Leu Ser Pro Arg Glu Asn Ser Tyr Glu Leu Ala Arg Leu 
    930                 935                 940                 


Glu Ala Leu Ala Gln Ala Tyr Gln Ser Ser Leu Arg Glu Leu Val Glu 
945                 950                 955                 960 


Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Ser Val Val Leu Gln Pro 
                965                 970                 975     


Phe Phe His Ser Ile Gln Leu Pro Val Leu Gln Asp Gly Arg Leu Asp 
            980                 985                 990         


Thr Ser Phe Phe Ala Pro Asp Cys  Val His Pro Asn Gln  Lys Phe His 
        995                 1000                 1005             


Ser Gln  Leu Ser Arg Ala Leu  Trp Arg Asn Met Leu  Glu Pro Leu 
    1010                 1015                 1020             


Gly Gly  Lys Thr Asp Ala Leu  Asp Leu Thr Ala Ala  Ile Thr Leu 
    1025                 1030                 1035             


Thr Cys  Pro Thr Gln Asn Glu  Pro Phe Leu Arg Thr  Phe Arg Asn 
    1040                 1045                 1050             


Ser Asp  Tyr Thr Tyr Pro Ser  Arg Pro Ala Val Glu  Asn Trp Gly 
    1055                 1060                 1065             


Ser Asp  Phe Leu Cys Thr Ala  Trp Asn Ala Ser Arg  Gly Val Pro 
    1070                 1075                 1080             


Asn Ser  Val His Glu Leu Gln  Pro Gly Asp Ile Lys  Val Val Ala 
    1085                 1090                 1095             


Ala Leu  Gly Asp Ser Leu Thr  Leu Ala Met Gly Ala  Arg Pro Ser 
    1100                 1105                 1110             


Asn Ser  Ser Asp Pro Pro Met  Phe Trp Arg Gly Leu  Ser Trp Ser 
    1115                 1120                 1125             


Ile Gly  Gly Asp Gly Ala Leu  Glu Thr His Thr Thr  Leu Pro Asn 
    1130                 1135                 1140             


Ile Leu  Lys Lys Phe Asn Pro  Ser Ile Leu Gly Phe  Ser Thr Gly 
    1145                 1150                 1155             


Thr Leu  Glu Gly Thr Met Gly  Leu Asn Val Ala Val  Gln Gly Ala 
    1160                 1165                 1170             


Arg Ala  Gln Asp Met Pro Ala  Gln Ala Arg Asp Leu  Val Glu Arg 
    1175                 1180                 1185             


Met Arg  Asn Ser Pro Glu Ile  Asp Leu Glu Lys Asp  Trp Lys Leu 
    1190                 1195                 1200             


Val Thr  Leu Phe Val Gly Gly  Asn Asp Leu Cys His  Phe Cys Glu 
    1205                 1210                 1215             


Asn Pro  Glu Gly Ser Ser Glu  Gly Glu Tyr Val Gln  His Ile Gln 
    1220                 1225                 1230             


Gln Ala  Leu Asp Val Leu Tyr  Glu Glu Leu Pro Arg  Thr Phe Val 
    1235                 1240                 1245             


Asn Val  Val Glu Val Met Glu  Leu Ala Gly Leu His  Gln Asp Gln 
    1250                 1255                 1260             


Gly Gly  Arg Cys Ala Thr Leu  Leu Ala Ala Gln Ser  His Cys Thr 
    1265                 1270                 1275             


Cys Phe  Lys Tyr Ser Gln Ser  Ser Val Glu Met Gln  Glu Leu Lys 
    1280                 1285                 1290             


Lys Val  Asn Trp Asn Leu Gln  Ser Gly Leu Ser Arg  Leu Ser Tyr 
    1295                 1300                 1305             


Ser His  Gln Tyr Val Gln Arg  Glu Asp Phe Ala Val  Val Val Gln 
    1310                 1315                 1320             


Pro Phe  Phe Gln Asn Thr Leu  Val Pro Leu Asn Gly  Arg Gly Asp 
    1325                 1330                 1335             


Thr Asp  Leu Thr Phe Phe Ser  Asp Asp Cys Phe His  Phe Ser Glu 
    1340                 1345                 1350             


Arg Gly  His Ala Glu Met Ala  Ile Ala Leu Trp Asn  Asn Met Leu 
    1355                 1360                 1365             


Glu Pro  Val Gly His Lys Thr  Thr Ser Asn Asn Phe  Thr Tyr Ser 
    1370                 1375                 1380             


Arg Thr  Lys Leu Lys Cys Pro  Ser Pro Asp Ser Pro  Tyr Leu Tyr 
    1385                 1390                 1395             


Thr Leu  Arg Asn Ser Arg Leu  Leu Pro Asp Gln Ala  Glu Ala Asp 
    1400                 1405                 1410             


Pro Thr  Val Leu Tyr Trp Ala  Val Pro Val Ala Ala  Gly Ala Gly 
    1415                 1420                 1425             


Leu Leu  Ile Gly Ile Leu Ala  Met Val Ala Gly Arg  Gly Met Arg 
    1430                 1435                 1440             


Cys Arg  Pro Arg Glu Asp Pro  Pro Leu Ser Leu Ser  Thr Gly Leu 
    1445                 1450                 1455             


<210>  79
<211>  1324
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Ser 
    1310                 1315                 1320             


Lys 
    


<210>  80
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Leu Leu Ser Arg Pro Ala Leu Thr Leu Leu Leu Leu Leu Met 
1               5                   10                  15      


Ala Ala Val Val Arg Cys Gln Glu Gln Ala Gln Thr Thr Asp Trp Arg 
            20                  25                  30          


Ala Thr Leu Lys Thr Ile Arg Asn Gly Val His Lys Ile Asp Thr Tyr 
        35                  40                  45              


Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly Leu Cys Gln 
    50                  55                  60                  


Tyr Lys Cys Ser Asp Gly Ser Lys Pro Phe Pro Arg Tyr Gly Tyr Lys 
65                  70                  75                  80  


Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly Val His Leu 
                85                  90                  95      


Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln His Asp Arg 
            100                 105                 110         


Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp Glu Glu Phe 
        115                 120                 125             


Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys Thr Leu Gly 
    130                 135                 140                 


Leu Thr Gln His Val Gln Ala Cys Glu Thr Thr Val Glu Leu Leu Phe 
145                 150                 155                 160 


Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp Ser Gln Arg 
                165                 170                 175     


Ala Ala Cys Arg Cys His Tyr Glu Glu Lys Thr Asp Leu 
            180                 185                 


<210>  81
<211>  1463
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  82
<211>  1474
<212>  PRT
<213>  Monodelphis domestica

<400>  82

Met Arg Leu Gln Pro Ser Leu Leu Leu Leu Ala Leu Leu Leu Leu Lys 
1               5                   10                  15      


Val Thr Thr Ile Gln Ala Thr Leu Gly Asn Asn Ser Trp Glu Glu Gln 
            20                  25                  30          


Thr Trp Pro Glu Gly Leu Lys Asn Phe Pro Phe Pro Cys Arg Pro Glu 
        35                  40                  45              


Glu Ile Pro Phe Ser Pro Pro Ser Glu Ser Val His Ser Leu Arg Ile 
    50                  55                  60                  


Ser Asp Ile Arg Val Val Gly Ala Ile Gly Asn Leu Glu Thr Thr Pro 
65                  70                  75                  80  


Asp Ala Lys Met Val Leu Lys Arg Gln Lys Trp Ile Glu Arg Asn Gln 
                85                  90                  95      


Met Gln Thr Cys Met Gln Val Met Thr Val Leu Ser Asp Phe Ile Lys 
            100                 105                 110         


Lys Phe Ser Pro Ser Val Leu Pro Leu Leu Cys Pro Ser Arg Glu Lys 
        115                 120                 125             


Val Leu Pro Arg Met Arg Asn Glu Asp Leu Gly Pro Gln Ala Arg Glu 
    130                 135                 140                 


Leu Val Gln His Met Lys Lys Asn Gln Lys Leu Asn Phe Arg Asn Asp 
145                 150                 155                 160 


Trp Lys Leu Ile Asn Val Phe Phe Asn Ala Gln Ser Gln Cys His Pro 
                165                 170                 175     


Cys Ser Ser Ser Gln Lys Glu Gly Asn Met Thr Ser Ser Met Gln Glu 
            180                 185                 190         


Leu Ile Arg Leu Leu Asp Tyr Leu Gln Lys Glu Val Pro Lys Ala Phe 
        195                 200                 205             


Val Asn Leu Val Asp Ile Ser Glu Leu Gly Asn Ser Ile Gln Ser Asn 
    210                 215                 220                 


Asn Gln Glu Asn Gly Pro Arg Asp Ile Asn Glu Val Cys Glu Cys Pro 
225                 230                 235                 240 


Gln Glu Pro Ser Arg Leu Thr Thr Ala Val Gln Arg Trp Tyr Tyr Gln 
                245                 250                 255     


Asn Ser Trp Glu Lys Leu Leu Thr Ser Gly Arg Tyr Asp Thr Lys Asp 
            260                 265                 270         


Thr Phe Thr Val Ile Tyr Gln Ser Phe Leu His Glu Met Glu Pro Ser 
        275                 280                 285             


Val Phe Pro Ile Lys Gln Thr Ser Gly Ser Ser Leu Lys Lys Leu Ser 
    290                 295                 300                 


Thr Ala Leu Ala Val Ser Leu Trp Asn Gly Met Ile Asp Pro Thr Gly 
305                 310                 315                 320 


Lys Lys Glu Glu Phe Phe Thr Thr Gly Gln Arg Ile Pro Val Lys Cys 
                325                 330                 335     


Pro Thr Gln Lys His Pro Tyr Leu Phe Thr Tyr Arg Asn Asn Asn Lys 
            340                 345                 350         


Leu Ser Ser Thr Pro Glu Ile Lys Arg Ile Ser Glu Thr Arg Glu Gly 
        355                 360                 365             


Thr Glu Ile Arg Cys Pro Asp Met Asp Pro Ser Asn Ala Val Pro Thr 
    370                 375                 380                 


Ser Val His His Leu Arg Pro Ala Asp Ile Lys Val Ile Gly Ala Leu 
385                 390                 395                 400 


Gly Asp Ser Leu Thr Ala Gly Asn Gly Ala Gly Ser Thr Pro Gly Asn 
                405                 410                 415     


Ile Leu Asp Val Leu Thr Gln Tyr Arg Gly Leu Ser Trp Ser Ile Gly 
            420                 425                 430         


Gly Asn Glu Asn Ile Ser Thr Val Thr Thr Leu Ala Asn Ile Leu Arg 
        435                 440                 445             


Glu Phe Asn Pro Ser Leu Ile Gly Phe Ser Thr Gly Thr Gly Asn Gln 
    450                 455                 460                 


Asn Ser Ala Ala Ala Phe Leu Asn Gln Ala Val Ala Gly Ala Thr Ser 
465                 470                 475                 480 


Glu Thr Leu Pro Ser Gln Ala Arg Arg Leu Val Asp Leu Met Lys Glu 
                485                 490                 495     


Asn Lys Arg Ile Asn Phe Gln Asp Asp Trp Lys Ile Val Thr Leu Phe 
            500                 505                 510         


Ile Gly Gly Asn Asp Leu Cys Asp Ser Cys Ser Asp Pro Pro Arg Tyr 
        515                 520                 525             


Ser Ser Gln Asn Phe Thr Ala His Ile Gly Lys Ala Leu Asp Ile Leu 
    530                 535                 540                 


His Ala Glu Val Pro Arg Val Phe Val Asn Leu Val Thr Val Leu Ser 
545                 550                 555                 560 


Ile Val Ser Leu Arg Glu Leu Tyr Gln Glu Glu Ser Ile Asn Cys Pro 
                565                 570                 575     


Arg Val Ile Leu Arg Ser Leu Cys Pro Cys Val Leu Lys Phe Lys Asp 
            580                 585                 590         


Asn Ser Thr Glu Leu Thr Thr Leu Ile Glu Leu Asn Lys Gln Tyr Gln 
        595                 600                 605             


Glu Glu Thr His Arg Leu Val Asp Ser Gly Arg Tyr Asp Thr Arg Asp 
    610                 615                 620                 


Asp Phe Thr Val Val Leu Gln Pro Phe Leu Glu Gln Val Pro Met Pro 
625                 630                 635                 640 


Lys Thr Pro Glu Gly Leu Pro Asp Ser Ser Phe Phe Ala Pro Asp Cys 
                645                 650                 655     


Phe His Phe His Ser Lys Ala His Ala Arg Val Ala Arg Ser Leu Trp 
            660                 665                 670         


Asn Asn Met Leu Glu Pro Val Gly Glu Lys Lys Lys Glu Glu Asn Leu 
        675                 680                 685             


Glu Asn Ile Val Asp Leu Ile Cys Pro Ser Glu Ser Gln Pro Tyr Leu 
    690                 695                 700                 


Arg Thr Tyr Lys Asn Ser Asn Tyr Thr Tyr Pro Thr Ala Thr Pro Thr 
705                 710                 715                 720 


Ser Ser Pro Lys Pro Asp Tyr Gly Ser Gln Leu Trp Cys Glu Asp Arg 
                725                 730                 735     


Ala Pro Ser Ala Ser Phe Pro Thr Ser Val His Ala Leu Lys Pro Ala 
            740                 745                 750         


Asp Ile Gln Val Val Ala Ala Val Gly Asp Ser Leu Thr Ala Gly Asn 
        755                 760                 765             


Gly Ile Gly Ser Lys Pro Asp Asp Leu Pro Asp Val Ile Thr Gln Tyr 
    770                 775                 780                 


Arg Gly Leu Ser Tyr Ser Ala Gly Gly Asp Ala Ser Leu Glu Ser Val 
785                 790                 795                 800 


Thr Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn Met Asn Leu Thr Gly 
                805                 810                 815     


Phe Ala Val Gly Val Gly Ser Ala Asp Asp Ala Asn Ala Phe Leu Asn 
            820                 825                 830         


Gln Ala Val Pro Gly Ala Lys Ala Glu Gly Leu Lys Lys Gln Val Gln 
        835                 840                 845             


Thr Leu Val Gln Lys Met Lys Ser Asp Pro Arg Ile Asn Phe Gln Arg 
    850                 855                 860                 


Asp Trp Lys Val Ile Thr Leu Leu Ile Gly Thr Thr Asp Leu Cys Asp 
865                 870                 875                 880 


Tyr Cys Thr Asp Ser Asn Leu Tyr Ser Ala Thr Asn Phe Ser Ala Tyr 
                885                 890                 895     


Leu Arg Asp Ala Leu Asp Phe Leu His Arg Glu Val Pro Arg Ala Leu 
            900                 905                 910         


Val Asn Leu Val Asp Phe Met Asn Pro Ile Ile Phe Arg Gln Val Phe 
        915                 920                 925             


Leu Gly Asn Gln Asp Lys Cys Pro Met Thr Gln Ala Cys Ser Leu Cys 
    930                 935                 940                 


Asn Cys Leu Leu Thr Val Arg Glu Asp Ser Pro Glu Leu Ala Arg Met 
945                 950                 955                 960 


Lys Glu Val Val Lys Val Tyr Gln Thr Lys Ile Arg Glu Leu Val Glu 
                965                 970                 975     


Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Thr Ile Val Leu Gln Pro 
            980                 985                 990         


Phe Leu Glu Glu Val Lys Leu Ala  Phe Gln Asp Gly Ile  Pro Asp Val 
        995                 1000                 1005             


Ser Phe  Phe Ala Pro Asp Cys  Ile His Pro Asn Gln  Lys Phe His 
    1010                 1015                 1020             


Ser Gln  Leu Ser Arg Ala Leu  Trp Asn Asn Met Leu  Gln Pro Leu 
    1025                 1030                 1035             


Gly Lys  Lys Met Asp Phe Leu  Asp Leu Thr Ala Asp  Thr Thr Leu 
    1040                 1045                 1050             


Ser Cys  Pro Ser Leu Glu Glu  Pro Phe Leu Arg Thr  Tyr Arg Asn 
    1055                 1060                 1065             


Ser Asn  Tyr Thr Tyr Pro Ala  Asn Pro Ala Ile Glu  Asn Trp Gly 
    1070                 1075                 1080             


Ser Asp  Phe Leu Cys Pro Glu  Gln Gly Ser Ser Asn  Ser Ala Pro 
    1085                 1090                 1095             


Ser Ser  Val His Gln Leu Arg  Pro Ala Asp Ile Lys  Val Val Ala 
    1100                 1105                 1110             


Ala Leu  Gly Asp Ser Leu Thr  Thr Ala Val Gly Ala  Gly Ala Lys 
    1115                 1120                 1125             


Asn Asn  Ser Asn Trp Ser Thr  Ala Trp Arg Gly Leu  Ser Trp Ser 
    1130                 1135                 1140             


Ile Gly  Gly Asp Gly Thr Leu  Glu Thr His Thr Thr  Leu Pro Asn 
    1145                 1150                 1155             


Ile Leu  Lys Lys Phe Asn Pro  His Leu His Gly Phe  Ser Thr Gly 
    1160                 1165                 1170             


Thr Gln  Glu Glu Ala Ala Gly  Leu Asn Val Ala Val  Glu Gly Ala 
    1175                 1180                 1185             


Ile Ala  Gln Asp Met Pro Ser  Gln Ala Arg Ile Leu  Val Asp Arg 
    1190                 1195                 1200             


Met Lys  Asn Ser Ser Glu Ile  Asn Leu Asp Gln Asp  Trp Lys Leu 
    1205                 1210                 1215             


Ile Thr  Ile Phe Val Gly Ser  Asn Asp Leu Cys Gln  Tyr Cys Glu 
    1220                 1225                 1230             


Asn Pro  Glu Ala His Ser Val  Lys Asn Tyr Val Gln  Ser Leu Gln 
    1235                 1240                 1245             


Gln Ala  Leu Asp Ile Phe Tyr  Lys Glu Leu Pro Arg  Ala Phe Ile 
    1250                 1255                 1260             


Asn Val  Val Glu Ile Met Glu  Leu Val Gly Leu Arg  Gln Ile Gln 
    1265                 1270                 1275             


Gly Glu  Lys Cys Ala Val Thr  Thr Gln Ser Ile Cys  Pro Cys Phe 
    1280                 1285                 1290             


Gly Arg  Ser Leu Asp Asn Ser  Pro Glu Leu Gln Glu  Met Lys Asn 
    1295                 1300                 1305             


Ile Asn  Arg His Phe Gln Ser  Gly Ser Ser Leu Ile  Thr Tyr His 
    1310                 1315                 1320             


His Gln  Tyr Met Glu Arg Glu  Asp Phe Ala Val Val  Val Gln Pro 
    1325                 1330                 1335             


Phe Phe  Gln Ser Thr Val Val  Pro Leu Asp Asp Lys  Gly Lys Pro 
    1340                 1345                 1350             


Asp Leu  Ser Phe Phe Ser Val  Asp Cys Phe His Phe  Ser Glu Arg 
    1355                 1360                 1365             


Gly His  Ala Glu Met Ala Ile  Ala Leu Trp Asn Asn  Met Leu Glu 
    1370                 1375                 1380             


Pro Val  Gly Gln Lys Gln Thr  Tyr Asn Asn Phe Thr  His Ser Arg 
    1385                 1390                 1395             


Thr Lys  Val Lys Cys Pro Thr  Ser Glu Asn Pro Tyr  Phe Phe Thr 
    1400                 1405                 1410             


Met Arg  Asn Ser Gly Leu Leu  Arg Lys Glu Ala Ser  His Lys Thr 
    1415                 1420                 1425             


Pro Ser  Val Pro Phe Trp Ala  Val Leu Val Ala Ala  Ala Ala Ser 
    1430                 1435                 1440             


Phe Ile  Val Gly Val Val Leu  Val Met Leu Trp Arg  Thr Lys Lys 
    1445                 1450                 1455             


Cys Ser  Arg Arg Glu Glu Arg  Pro Ile Ser Leu Val  Ala Thr Val 
    1460                 1465                 1470             


Phe 
    


<210>  83
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ile Ala Phe Leu Leu Thr Ser Val Leu Met Ile Pro His Ala Gly 
1               5                   10                  15      


Gly His Pro Leu Asp Thr Pro His Leu Pro Gln Glu Leu Pro Pro Gly 
            20                  25                  30          


Leu Pro Asn Asn Ile Asn Ile Thr Phe Phe Ser Gly Met Phe Lys Asn 
        35                  40                  45              


Val Glu Ser Val Ala Glu Ile Phe Asp Cys Leu Gly Ala His Phe Thr 
    50                  55                  60                  


Trp Leu Gln Ala Val Phe Thr Asn Phe Pro Val Leu Ile Gln Phe Val 
65                  70                  75                  80  


Asn Gly Met Lys Cys Val Ala Gly Leu Cys Pro Arg Asp Phe Glu Asp 
                85                  90                  95      


Tyr Gly Cys Thr Cys Arg Phe Glu Met Glu Gly Leu Pro Val Asp Glu 
            100                 105                 110         


Ser Asp Ser Cys Cys Phe Gln His Arg Arg Cys Cys Glu Glu Ala Ala 
        115                 120                 125             


Glu Met Asp Cys Leu Gln Asp Pro Ala Lys Leu Ser Thr Glu Val Asp 
    130                 135                 140                 


Cys Val Gly Lys Lys Ile Ile Cys Glu Ser Lys Asp Asn Cys Glu His 
145                 150                 155                 160 


Leu Leu Cys Thr Cys Asp Lys Ala Ala Ile Glu Cys Leu Ala Arg Ser 
                165                 170                 175     


Ser Leu Asn Ser Ser Leu Asn Leu Leu Asp Thr Ser Phe Cys Leu Ala 
            180                 185                 190         


Gln Thr Pro Glu Thr Thr Ile Lys Glu Asp Leu Thr Thr Leu Leu Pro 
        195                 200                 205             


Arg Val Val Pro Val Glu Pro Thr Asp Thr Ser Leu Thr Ala Leu Ser 
    210                 215                 220                 


Gly Glu Val Ala Ala Glu Thr Glu Ala Asp Arg Leu Ile Thr Leu Ser 
225                 230                 235                 240 


Lys Lys Lys Ala Gly His Asp Gln Glu Gly Val Gly Ala Ala Arg Ala 
                245                 250                 255     


Thr Ser Pro Pro Gly Ser Ala Glu Ile Val Ala Thr Arg Val Thr Ala 
            260                 265                 270         


Lys Ile Val Thr Leu Val Pro Ala Gly Ile Lys Ser Leu Gly Leu Ala 
        275                 280                 285             


Val Ser Ser Val Glu Asn Asp Pro Glu Glu Thr Thr Glu Lys Ala Cys 
    290                 295                 300                 


Asp Arg Phe Thr Phe Leu His Leu Gly Ser Gly Asp Asn Met Gln Val 
305                 310                 315                 320 


Met Pro Gln Leu Gly Glu Met Leu Phe Cys Leu Thr Ser Arg Cys Pro 
                325                 330                 335     


Glu Glu Phe Glu Ser Tyr Gly Cys Tyr Cys Gly Gln Glu Gly Arg Gly 
            340                 345                 350         


Glu Pro Arg Asp Asp Leu Asp Arg Cys Cys Leu Ser His His Cys Cys 
        355                 360                 365             


Leu Glu Gln Val Arg Arg Leu Gly Cys Leu Leu Glu Arg Leu Pro Trp 
    370                 375                 380                 


Ser Pro Val Val Cys Val Asp His Thr Pro Lys Cys Gly Gly Gln Ser 
385                 390                 395                 400 


Leu Cys Glu Lys Leu Leu Cys Ala Cys Asp Gln Thr Ala Ala Glu Cys 
                405                 410                 415     


Met Thr Ser Ala Ser Phe Asn Gln Ser Leu Lys Ser Pro Ser Arg Leu 
            420                 425                 430         


Gly Cys Pro Gly Gln Pro Ala Ala Cys Glu Asp Ser Leu His Pro Val 
        435                 440                 445             


Pro Ala Ala Pro Thr Leu Gly Ser Ser Ser Glu Glu Asp Ser Glu Glu 
    450                 455                 460                 


Asp Pro Pro Gln Glu Asp Leu Gly Arg Ala Lys Arg Phe Leu Arg Lys 
465                 470                 475                 480 


Ser Leu Gly Pro Leu Gly Ile Gly Pro Leu His Gly Arg 
                485                 490             


<210>  84
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Phe Pro Arg Glu Lys Thr Trp Asn Ile Ser Phe Ala Gly Cys Gly 
1               5                   10                  15      


Phe Leu Gly Val Tyr Tyr Val Gly Val Ala Ser Cys Leu Arg Glu His 
            20                  25                  30          


Ala Pro Phe Leu Val Ala Asn Ala Thr His Ile Tyr Gly Ala Ser Ala 
        35                  40                  45              


Gly Ala Leu Thr Ala Thr Ala Leu Val Thr Gly Val Cys Leu Gly Glu 
    50                  55                  60                  


Ala Gly Ala Lys Phe Ile Glu Val Ser Lys Glu Ala Arg Lys Arg Phe 
65                  70                  75                  80  


Leu Gly Pro Leu His Pro Ser Phe Asn Leu Val Lys Ile Ile Arg Ser 
                85                  90                  95      


Phe Leu Leu Lys Val Leu Pro Ala Asp Ser His Glu His Ala Ser Gly 
            100                 105                 110         


Arg Leu Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Ile 
        115                 120                 125             


Ile Ser His Phe Asn Ser Lys Asp Glu Leu Ile Gln Ala Asn Val Cys 
    130                 135                 140                 


Ser Gly Phe Ile Pro Val Tyr Cys Gly Leu Ile Pro Pro Ser Leu Gln 
145                 150                 155                 160 


Gly Val Arg Tyr Val Asp Gly Gly Ile Ser Asp Asn Leu Pro Leu Tyr 
                165                 170                 175     


Glu Leu Lys Asn Thr Ile Thr Val Ser Pro Phe Ser Gly Glu Ser Asp 
            180                 185                 190         


Ile Cys Pro Gln Asp Ser Ser Thr Asn Ile His Glu Leu Arg Val Thr 
        195                 200                 205             


Asn Thr Ser Ile Gln Phe Asn Leu Arg Asn Leu Tyr Arg Leu Ser Lys 
    210                 215                 220                 


Ala Leu Phe Pro Pro Glu Pro Leu Val Leu Arg Glu Met Cys Lys Gln 
225                 230                 235                 240 


Gly Tyr Arg Asp Gly Leu Arg Phe Leu Gln Arg Asn Gly Leu Leu Asn 
                245                 250                 255     


Arg Pro Asn Pro Leu Leu Ala Leu Pro Pro Ala Arg Pro His Gly Pro 
            260                 265                 270         


Glu Asp Lys Asp Gln Ala Val Glu Ser Ala Gln Ala Glu Asp Tyr Ser 
        275                 280                 285             


Gln Leu Pro Gly Glu Asp His Ile Leu Glu His Leu Pro Ala Arg Leu 
    290                 295                 300                 


Asn Glu Ala Leu Leu Glu Ala Cys Val Glu Pro Thr Asp Leu Leu Thr 
305                 310                 315                 320 


Thr Leu Ser Asn Met Leu Pro Val Arg Leu Ala Thr Ala Met Met Val 
                325                 330                 335     


Pro Tyr Thr Leu Pro Leu Glu Ser Ala Leu Ser Phe Thr Ile Arg Leu 
            340                 345                 350         


Leu Glu Trp Leu Pro Asp Val Pro Glu Asp Ile Arg Trp Met Lys Glu 
        355                 360                 365             


Gln Thr Gly Ser Ile Cys Gln Tyr Leu Val Met Arg Ala Lys Arg Lys 
    370                 375                 380                 


Leu Gly Arg His Leu Pro Ser Arg Leu Pro Glu Gln Val Glu Leu Arg 
385                 390                 395                 400 


Arg Val Gln Ser Leu Pro Ser Val Pro Leu Ser Cys Ala Ala Tyr Arg 
                405                 410                 415     


Glu Ala Leu Pro Gly Trp Met Arg Asn Asn Leu Ser Leu Gly Asp Ala 
            420                 425                 430         


Leu Ala Lys Trp Glu Glu Cys Gln Arg Gln Leu Leu Leu Gly Leu Phe 
        435                 440                 445             


Cys Thr Asn Val Ala Phe Pro Pro Glu Ala Leu Arg Met Arg Ala Pro 
    450                 455                 460                 


Ala Asp Pro Ala Pro Ala Pro Ala Asp Pro Ala Ser Pro Gln His Gln 
465                 470                 475                 480 


Leu Ala Gly Pro Ala Pro Leu Leu Ser Thr Pro Ala Pro Glu Ala Arg 
                485                 490                 495     


Pro Val Ile Gly Ala Leu Gly Leu 
            500                 


<210>  85
<211>  151
<212>  PRT
<213>  Rattus norvegicus

<400>  85

Met Leu Leu Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Cys Leu 
1               5                   10                  15      


Ser Glu Ala Thr Arg Arg Ser His Val Tyr Lys Arg Gly Leu Leu Glu 
            20                  25                  30          


Leu Ala Gly Thr Leu Asp Cys Val Gly Pro Arg Ser Pro Met Ala Tyr 
        35                  40                  45              


Met Asn Tyr Gly Cys Tyr Cys Gly Leu Gly Gly His Gly Glu Pro Arg 
    50                  55                  60                  


Asp Ala Ile Asp Trp Cys Cys Tyr Tyr His Asp Cys Cys Tyr Ser Gln 
65                  70                  75                  80  


Ala Gln Asp Ala Gly Cys Ser Pro Lys Leu Tyr Arg Tyr Pro Trp Lys 
                85                  90                  95      


Cys Met Asp His Arg Ile Leu Cys Gly Pro Ala Glu Asn Lys Cys Gln 
            100                 105                 110         


Glu Leu Leu Cys Arg Cys Asp Glu Thr Leu Ala Tyr Cys Leu Ala Asp 
        115                 120                 125             


Thr Glu Tyr His Leu Lys Tyr Leu Phe Phe Pro Ser Val Leu Cys Glu 
    130                 135                 140                 


Lys Asp Ser Pro Lys Cys Asn 
145                 150     


<210>  86
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  86

Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr Thr Gly Lys Glu 
1               5                   10                  15      


Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys Gly Val Gly Gly 
            20                  25                  30          


Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys Val Thr His Asp 
        35                  40                  45              


Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly Thr Lys Phe Leu 
    50                  55                  60                  


Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr Cys Ala Lys Gln 
65                  70                  75                  80  


Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys Ala Ala Ala Thr 
                85                  90                  95      


Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys Tyr Gln Tyr Tyr 
            100                 105                 110         


Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
        115                 120                 


<210>  87
<211>  1487
<212>  PRT
<213>  Mus musculus

<400>  87

Met Val Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu Gln Gln Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ile His Gln Gly Ile Ala Gln Asp Leu Thr His Ile 
            20                  25                  30          


Gln Glu Pro Ser Leu Glu Trp Arg Asp Lys Gly Ile Phe Ile Ile Gln 
        35                  40                  45              


Ser Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser Val Leu Thr 
    50                  55                  60                  


Leu Glu Asn Cys Lys Gln Pro Asn Glu His Met Leu Trp Lys Trp Val 
65                  70                  75                  80  


Ser Asp Asp His Leu Phe Asn Val Gly Gly Ser Gly Cys Leu Gly Leu 
                85                  90                  95      


Asn Ile Ser Ala Leu Glu Gln Pro Leu Lys Leu Tyr Glu Cys Asp Ser 
            100                 105                 110         


Thr Leu Ile Ser Leu Arg Trp His Cys Asp Arg Lys Met Ile Glu Gly 
        115                 120                 125             


Pro Leu Gln Tyr Lys Val Gln Val Lys Ser Asp Asn Thr Val Val Ala 
    130                 135                 140                 


Arg Lys Gln Ile His Arg Trp Ile Ala Tyr Thr Ser Ser Gly Gly Asp 
145                 150                 155                 160 


Ile Cys Glu His Pro Ser Arg Asp Leu Tyr Thr Leu Lys Gly Asn Ala 
                165                 170                 175     


His Gly Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly His Trp His 
            180                 185                 190         


His Asp Cys Ile Arg Glu Gly Gln Lys Glu His Leu Leu Trp Cys Ala 
        195                 200                 205             


Thr Thr Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe Cys Pro Asp 
    210                 215                 220                 


Pro Thr Ser Met Lys Val Phe Cys Asp Ala Thr Trp Gln Arg Asn Gly 
225                 230                 235                 240 


Ser Ser Arg Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp 
                245                 250                 255     


Asn Gln Ala His Ser Ser Cys Leu Met Gln Gly Gly Ala Leu Leu Ser 
            260                 265                 270         


Ile Ala Asp Glu Asp Glu Glu Asp Phe Ile Arg Lys His Leu Ser Lys 
        275                 280                 285             


Val Val Lys Glu Val Trp Ile Gly Leu Asn Gln Leu Asp Glu Lys Ala 
    290                 295                 300                 


Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser 
305                 310                 315                 320 


Gln Glu Ile Thr Pro Gly Pro Phe Val Glu His His Cys Gly Thr Leu 
                325                 330                 335     


Glu Val Val Ser Ala Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu 
            340                 345                 350         


Pro Tyr Ile Cys Lys Arg Asp Leu Asn His Thr Ala Gln Gly Ile Leu 
        355                 360                 365             


Glu Lys Asp Ser Trp Lys Tyr His Ala Thr His Cys Asp Pro Asp Trp 
    370                 375                 380                 


Thr Pro Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Asp Arg Lys Ser 
385                 390                 395                 400 


Trp Leu Gly Ala Leu His Ser Cys Gln Ser Asn Asp Ser Val Leu Met 
                405                 410                 415     


Asp Val Ala Ser Leu Ala Glu Val Glu Phe Leu Val Ser Leu Leu Arg 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Ser Gly Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp Tyr Pro Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Glu Ser Asp Gly Arg Trp Lys Val Lys Asp Cys Lys 
                485                 490                 495     


Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly Gln Val Pro Ala Asp 
            500                 505                 510         


Glu Gln Ser Gly Cys Pro Ala Gly Trp Glu Arg His Gly Arg Phe Cys 
        515                 520                 525             


Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Glu Glu Ala Ser Ser Gly 
    530                 535                 540                 


Tyr Tyr Cys Ser Pro Ala Leu Leu Thr Ile Thr Ser Arg Phe Glu Gln 
545                 550                 555                 560 


Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Ala Glu Lys Asp Ser Tyr 
                565                 570                 575     


Phe Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp 
            580                 585                 590         


Lys Thr Val Gly Gln Arg Glu Pro Val Gln Tyr Thr Tyr Trp Asn Thr 
        595                 600                 605             


Arg Gln Pro Ser Asn Arg Gly Gly Cys Val Val Val Arg Gly Gly Ser 
    610                 615                 620                 


Ser Leu Gly Arg Trp Glu Val Lys Asp Cys Ser Asp Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Thr Pro Val Lys Ile Trp Glu Lys Thr Glu Leu Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu Ser Ala Thr 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Arg Arg Asn Pro Leu Asn Ala Gly Ser Trp Ala Trp Ser 
            740                 745                 750         


Asp Gly Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala Tyr Phe Glu 
        755                 760                 765             


Glu Asp Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Ser Asn Cys Ala Ser Lys His Glu Trp Ile Cys Arg Ile Pro Arg 
785                 790                 795                 800 


Asp Val Arg Pro Lys Phe Pro Asp Trp Tyr Gln Tyr Asp Ala Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His Pro Ala Glu 
            820                 825                 830         


Trp Ala Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Phe Leu 
        835                 840                 845             


Thr Ile Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Gly Leu Thr Lys Tyr Gly Val Lys Trp Trp Ile Gly Leu Glu Glu Gly 
865                 870                 875                 880 


Gly Ala Arg Asp Gln Ile Gln Trp Ser Asn Gly Ser Pro Val Ile Phe 
                885                 890                 895     


Gln Asn Trp Asp Lys Gly Arg Glu Glu Arg Val Asp Ser Gln Arg Lys 
            900                 905                 910         


Arg Cys Val Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Thr Glu Asn 
        915                 920                 925             


Cys Ser Val Pro Leu Pro Ser Ile Cys Lys Arg Val Lys Ile Trp Val 
    930                 935                 940                 


Ile Glu Lys Glu Lys Pro Pro Thr Gln Pro Gly Thr Cys Pro Lys Gly 
945                 950                 955                 960 


Trp Leu Tyr Phe Asn Tyr Lys Cys Phe Leu Val Thr Ile Pro Lys Asp 
                965                 970                 975     


Pro Arg Glu Leu Lys Thr Trp Thr Gly Ala Gln Glu Phe Cys Val Ala 
            980                 985                 990         


Lys Gly Gly Thr Leu Val Ser Ile  Lys Ser Glu Leu Glu  Gln Ala Phe 
        995                 1000                 1005             


Ile Thr  Met Asn Leu Phe Gly  Gln Thr Thr Asn Val  Trp Ile Gly 
    1010                 1015                 1020             


Leu Gln  Ser Thr Asn His Glu  Lys Trp Val Asn Gly  Lys Pro Leu 
    1025                 1030                 1035             


Val Tyr  Ser Asn Trp Ser Pro  Ser Asp Ile Ile Asn  Ile Pro Ser 
    1040                 1045                 1050             


Tyr Asn  Thr Thr Glu Phe Gln  Lys His Ile Pro Leu  Cys Ala Leu 
    1055                 1060                 1065             


Met Ser  Ser Asn Pro Asn Phe  His Phe Thr Gly Lys  Trp Tyr Phe 
    1070                 1075                 1080             


Asp Asp  Cys Gly Lys Glu Gly  Tyr Gly Phe Val Cys  Glu Lys Met 
    1085                 1090                 1095             


Gln Asp  Thr Leu Glu His His  Val Asn Val Ser Asp  Thr Ser Ala 
    1100                 1105                 1110             


Ile Pro  Ser Thr Leu Glu Tyr  Gly Asn Arg Thr Tyr  Lys Ile Ile 
    1115                 1120                 1125             


Arg Gly  Asn Met Thr Trp Tyr  Ala Ala Gly Lys Ser  Cys Arg Met 
    1130                 1135                 1140             


His Arg  Ala Glu Leu Ala Ser  Ile Pro Asp Ala Phe  His Gln Ala 
    1145                 1150                 1155             


Phe Leu  Thr Val Leu Leu Ser  Arg Leu Gly His Thr  His Trp Ile 
    1160                 1165                 1170             


Gly Leu  Ser Thr Thr Asp Asn  Gly Gln Thr Phe Asp  Trp Ser Asp 
    1175                 1180                 1185             


Gly Thr  Lys Ser Pro Phe Thr  Tyr Trp Lys Asp Glu  Glu Ser Ala 
    1190                 1195                 1200             


Phe Leu  Gly Asp Cys Ala Phe  Ala Asp Thr Asn Gly  Arg Trp His 
    1205                 1210                 1215             


Ser Thr  Ala Cys Glu Ser Phe  Leu Gln Gly Ala Ile  Cys His Val 
    1220                 1225                 1230             


Val Thr  Glu Thr Lys Ala Phe  Glu His Pro Gly Leu  Cys Ser Glu 
    1235                 1240                 1245             


Thr Ser  Val Pro Trp Ile Lys  Phe Lys Gly Asn Cys  Tyr Ser Phe 
    1250                 1255                 1260             


Ser Thr  Val Leu Asp Ser Arg  Ser Phe Glu Asp Ala  His Glu Phe 
    1265                 1270                 1275             


Cys Lys  Ser Glu Gly Ser Asn  Leu Leu Ala Ile Arg  Asp Ala Ala 
    1280                 1285                 1290             


Glu Asn  Ser Phe Leu Leu Glu  Glu Leu Leu Ala Phe  Gly Ser Ser 
    1295                 1300                 1305             


Val Gln  Met Val Trp Leu Asn  Ala Gln Phe Asp Asn  Asn Asn Lys 
    1310                 1315                 1320             


Thr Leu  Arg Trp Phe Asp Gly  Thr Pro Thr Glu Gln  Ser Asn Trp 
    1325                 1330                 1335             


Gly Leu  Arg Lys Pro Asp Met  Asp His Leu Lys Pro  His Pro Cys 
    1340                 1345                 1350             


Val Val  Leu Arg Ile Pro Glu  Gly Ile Trp His Phe  Thr Pro Cys 
    1355                 1360                 1365             


Glu Asp  Lys Lys Gly Phe Ile  Cys Lys Met Glu Ala  Gly Ile Pro 
    1370                 1375                 1380             


Ala Val  Thr Ala Gln Pro Glu  Lys Gly Leu Ser His  Ser Ile Val 
    1385                 1390                 1395             


Pro Val  Thr Val Thr Leu Thr  Leu Ile Ile Ala Leu  Gly Ile Phe 
    1400                 1405                 1410             


Met Leu  Cys Phe Trp Ile Tyr  Lys Gln Lys Ser Asp  Ile Phe Gln 
    1415                 1420                 1425             


Arg Leu  Thr Gly Ser Arg Gly  Ser Tyr Tyr Pro Thr  Leu Asn Phe 
    1430                 1435                 1440             


Ser Thr  Ala His Leu Glu Glu  Asn Ile Leu Ile Ser  Asp Leu Glu 
    1445                 1450                 1455             


Lys Asn  Thr Asn Asp Glu Glu  Val Arg Asp Ala Pro  Ala Thr Glu 
    1460                 1465                 1470             


Ser Lys  Arg Gly His Lys Gly  Arg Pro Ile Cys Ile  Ser Pro 
    1475                 1480                 1485         


<210>  88
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Leu Leu Ser Arg Pro Ala Leu Thr Leu Leu Leu Leu Leu Met 
1               5                   10                  15      


Ala Ala Val Val Arg Cys Gln Glu Gln Ala Gln Thr Thr Asp Trp Arg 
            20                  25                  30          


Ala Thr Leu Lys Thr Ile Arg Asn Gly Val His Lys Ile Asp Thr Tyr 
        35                  40                  45              


Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly Leu Cys Gln 
    50                  55                  60                  


Tyr Lys Cys Ser Asp Gly Ser Lys Pro Phe Pro Arg Tyr Gly Tyr Lys 
65                  70                  75                  80  


Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly Val His Leu 
                85                  90                  95      


Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln His Asp Arg 
            100                 105                 110         


Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp Glu Glu Phe 
        115                 120                 125             


Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys Thr Leu Gly 
    130                 135                 140                 


Leu Thr Gln His Val Gln Ala Cys Glu Thr Thr Val Glu Leu Leu Phe 
145                 150                 155                 160 


Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp Ser Gln Arg 
                165                 170                 175     


Ala Ala Cys Arg Cys His Tyr Glu Glu Lys Thr Asp Leu 
            180                 185                 


<210>  89
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Lys Leu Ala Ser Gly Phe Leu Val Leu Trp Leu Ser Leu Gly Gly 
1               5                   10                  15      


Gly Leu Ala Gln Ser Asp Thr Ser Pro Asp Thr Glu Glu Ser Tyr Ser 
            20                  25                  30          


Asp Trp Gly Leu Arg His Leu Arg Gly Ser Phe Glu Ser Val Asn Ser 
        35                  40                  45              


Tyr Phe Asp Ser Phe Leu Glu Leu Leu Gly Gly Lys Asn Gly Val Cys 
    50                  55                  60                  


Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr 
65                  70                  75                  80  


Lys Pro Gln Glu Pro Asn Gly Cys Gly Ser Tyr Phe Leu Gly Leu Lys 
                85                  90                  95      


Val Pro Glu Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys 
            100                 105                 110         


Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg 
        115                 120                 125             


Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu 
    130                 135                 140                 


Lys Arg Ser Leu Gly Phe Val Ser Lys Val Glu Ala Ala Cys Asp Ser 
145                 150                 155                 160 


Leu Val Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro 
                165                 170                 175     


Phe Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys 
            180                 185                 190         


Glu Glu Leu 
        195 


<210>  90
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  90

Met Lys Leu Leu Cys Gly Phe Phe Leu Leu Trp Leu Gly Leu Val Gly 
1               5                   10                  15      


Asn Leu Ala Gln Ser Asp Pro Ser Pro Lys Glu Glu Glu Ser Tyr Ser 
            20                  25                  30          


Asp Trp Gly Leu Arg Gln Leu Arg Gly Ser Phe Glu Ser Val Asn Ser 
        35                  40                  45              


Tyr Val Asp Ser Phe Met Glu Leu Leu Gly Gly Lys Asn Gly Val Cys 
    50                  55                  60                  


Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr 
65                  70                  75                  80  


Lys Ala Gln Glu Pro Asn Gly Cys Ser Ser Tyr Phe Leu Gly Ile Lys 
                85                  90                  95      


Val Pro Gly Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys 
            100                 105                 110         


Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg 
        115                 120                 125             


Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu 
    130                 135                 140                 


Lys Arg Ser Leu Gly Phe Val Ser Asn Val Glu Ala Ala Cys Asp Ser 
145                 150                 155                 160 


Leu Ala Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro 
                165                 170                 175     


Phe Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys 
            180                 185                 190         


Glu Glu Leu 
        195 


<210>  91
<211>  192
<212>  PRT
<213>  Mus musculus

<400>  91

Met Val Thr Pro Arg Pro Ala Pro Ala Arg Ser Pro Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Thr Ala Arg Gly Gln Glu Gln Asp Gln Thr Thr 
            20                  25                  30          


Asp Trp Arg Ala Thr Leu Lys Thr Ile Arg Asn Gly Ile His Lys Ile 
        35                  40                  45              


Asp Thr Tyr Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly 
    50                  55                  60                  


Leu Cys Gln Tyr Lys Cys Ser Asp Gly Ser Lys Pro Val Pro Arg Tyr 
65                  70                  75                  80  


Gly Tyr Lys Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly 
                85                  90                  95      


Val His Leu Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln 
            100                 105                 110         


His Asp Arg Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp 
        115                 120                 125             


Glu Glu Phe Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys 
    130                 135                 140                 


Thr Leu Gly Leu Ser Gln Asn Val Gln Ala Cys Glu Thr Thr Val Glu 
145                 150                 155                 160 


Leu Leu Phe Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp 
                165                 170                 175     


Ser Gln Arg Ala Ala Cys Trp Cys Arg Tyr Glu Glu Lys Thr Asp Leu 
            180                 185                 190         


<210>  92
<211>  144
<212>  PRT
<213>  Mus musculus

<400>  92

Met Arg Leu Ala Leu Leu Cys Gly Leu Leu Leu Ala Gly Ile Thr Ala 
1               5                   10                  15      


Thr Gln Gly Gly Leu Leu Asn Leu Asn Lys Met Val Thr His Met Thr 
            20                  25                  30          


Gly Lys Lys Ala Phe Phe Ser Tyr Trp Pro Tyr Gly Cys His Cys Gly 
        35                  40                  45              


Leu Gly Gly Lys Gly Gln Pro Lys Asp Ala Thr Asp Trp Cys Cys Gln 
    50                  55                  60                  


Lys His Asp Cys Cys Tyr Ala His Leu Lys Ile Asp Gly Cys Lys Ser 
65                  70                  75                  80  


Leu Thr Asp Asn Tyr Lys Tyr Ser Ile Ser Gln Gly Thr Ile Gln Cys 
                85                  90                  95      


Ser Asp Asn Gly Ser Trp Cys Glu Arg Gln Leu Cys Ala Cys Asp Lys 
            100                 105                 110         


Glu Val Ala Leu Cys Leu Lys Gln Asn Leu Asp Ser Tyr Asn Lys Arg 
        115                 120                 125             


Leu Arg Tyr Tyr Trp Arg Pro Arg Cys Lys Gly Lys Thr Pro Ala Cys 
    130                 135                 140                 


<210>  93
<211>  855
<212>  PRT
<213>  Mus musculus

<400>  93

Met Pro Trp Thr Leu Gln Pro Lys Trp Leu Ala Gly Lys Gly Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ala Ile Leu Leu Arg Lys Thr Glu Lys Ser Glu Pro Gln 
            20                  25                  30          


Trp Lys His Arg Arg Gln Glu Thr His Pro Tyr Tyr Asp Leu Gln Val 
        35                  40                  45              


Lys Val Leu Arg Ala Arg Asn Ile Gln His Thr Asp Lys Leu Ser Lys 
    50                  55                  60                  


Ala Asp Cys Tyr Val Arg Leu Trp Leu Pro Thr Ala Ser Val Ser Pro 
65                  70                  75                  80  


Ser Gln Thr Arg Thr Val Val Asn Ser Ser Asp Pro Glu Trp Asn Glu 
                85                  90                  95      


Thr Phe Pro Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu 
            100                 105                 110         


Ala Leu Tyr Asp Glu Asp Val Leu Asp Ser Asp Asn Val Phe Ser Ile 
        115                 120                 125             


Leu Phe Asp Thr Ser Thr Leu Gln Leu Gly Gln Pro Cys Thr Lys Asn 
    130                 135                 140                 


Phe Thr Arg Gln Gln Asp Pro Lys Glu Leu Glu Val Glu Phe Thr Leu 
145                 150                 155                 160 


Glu Lys Ser Gln Thr Pro Ala Ser Glu Val Val Thr Asn Gly Val Leu 
                165                 170                 175     


Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Val Thr Gly Asp Lys 
            180                 185                 190         


Thr Ala Ser Leu Gly Glu Leu Gly Ser Arg Gln Ile Gln Leu Ala Val 
        195                 200                 205             


Pro Gly Ala Tyr Glu Lys Pro Gln Pro Leu Gln Pro Thr Ser Glu Pro 
    210                 215                 220                 


Gly Leu Pro Val Asn Phe Thr Phe His Val Asn Pro Val Leu Ser Pro 
225                 230                 235                 240 


Lys Leu His Ile Lys Leu Gln Glu Gln Leu Gln Val Phe His Ser Gly 
                245                 250                 255     


Pro Ser Asp Glu Leu Glu Ala Gln Thr Ser Lys Met Asp Lys Ala Ser 
            260                 265                 270         


Ile Leu Leu Ser Ser Leu Pro Leu Asn Glu Glu Leu Thr Lys Leu Val 
        275                 280                 285             


Asp Leu Glu Glu Gly Gln Gln Val Ser Leu Arg Met Lys Ala Asp Met 
    290                 295                 300                 


Ser Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu Cys Asp 
305                 310                 315                 320 


Gly Glu Gln Glu Phe Leu Asp Lys Arg Lys Gln Val Ala Ser Lys Ala 
                325                 330                 335     


Leu Gln Arg Val Met Gly Leu Ser Glu Ala Leu His Cys Asp Gln Val 
            340                 345                 350         


Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala Met Thr 
        355                 360                 365             


Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Leu Leu Asp 
    370                 375                 380                 


Ala Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Ser Trp Cys Ile Ser 
385                 390                 395                 400 


Thr Leu Tyr Arg Asp Pro Ser Trp Ser Gln Lys Ala Leu Gln Gly Pro 
                405                 410                 415     


Ile Lys Tyr Ala Ser Glu Arg Val Cys Ser Ser Lys Ile Gly Met Leu 
            420                 425                 430         


Ser Pro Lys Gln Phe Glu Tyr Tyr Ser Arg Glu Lys Arg Ala Trp Glu 
        435                 440                 445             


Ser Arg Gly His Ser Met Ser Phe Thr Asp Leu Trp Gly Leu Ile Ile 
    450                 455                 460                 


Glu Tyr Phe Leu Asn Gln Glu Glu Asn Pro Ala Lys Leu Ser Asp Gln 
465                 470                 475                 480 


Gln Glu Thr Val Ser Gln Gly Gln Asn Pro Tyr Pro Ile Tyr Ala Ser 
                485                 490                 495     


Ile Asn Val His Lys Asn Ile Ser Gly Asp Asp Phe Ala Glu Trp Cys 
            500                 505                 510         


Glu Phe Thr Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala Tyr Val 
        515                 520                 525             


Pro Thr Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Arg Leu Leu His 
    530                 535                 540                 


Phe Trp Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Trp Gly Ser 
545                 550                 555                 560 


Ala Phe Ala Ala Ser Leu Tyr Glu Ile Phe Leu Lys Leu Gly Gly Leu 
                565                 570                 575     


Ser Leu Ser Phe Leu Asp Trp His Arg Gly Ser Val Ser Val Thr Asp 
            580                 585                 590         


Asp Trp Pro Lys Leu Arg Lys Gln Asp Pro Thr Arg Leu Pro Thr Arg 
        595                 600                 605             


Leu Phe Thr Pro Met Ser Ser Phe Ser Gln Ala Val Leu Asp Ile Phe 
    610                 615                 620                 


Thr Ser Arg Ile Thr Cys Ala Gln Thr Phe Asn Phe Thr Arg Gly Leu 
625                 630                 635                 640 


Cys Met Tyr Lys Asp Tyr Thr Ala Arg Lys Asp Phe Val Val Ser Glu 
                645                 650                 655     


Asp Ala Trp His Ser His Asn Tyr Gly Tyr Pro Asp Ala Cys Pro Asn 
            660                 665                 670         


Gln Leu Thr Pro Met Lys Asp Phe Leu Ser Leu Val Asp Gly Gly Phe 
        675                 680                 685             


Ala Ile Asn Ser Pro Phe Pro Leu Val Leu Gln Pro Gln Arg Ala Val 
    690                 695                 700                 


Asp Leu Ile Val Ser Phe Asp Tyr Ser Leu Glu Gly Pro Phe Glu Val 
705                 710                 715                 720 


Leu Gln Val Thr Glu Lys Tyr Cys Arg Asp Arg Gly Ile Pro Phe Pro 
                725                 730                 735     


Arg Ile Glu Val Asp Pro Lys Asp Ser Glu Asp Pro Arg Glu Cys Tyr 
            740                 745                 750         


Leu Phe Ala Glu Ala Glu Asp Pro Cys Ser Pro Ile Val Leu His Phe 
        755                 760                 765             


Pro Leu Val Asn Arg Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu 
    770                 775                 780                 


Arg Gln Thr Ala Glu Glu Lys Ala Phe Gly Asp Phe Ile Ile Asn Gly 
785                 790                 795                 800 


Pro Asp Thr Ala Tyr Gly Met Met Asp Phe Thr Tyr Glu Pro Lys Glu 
                805                 810                 815     


Phe Asp Arg Leu Val Thr Leu Ser Arg Tyr Asn Val Leu Asn Asn Lys 
            820                 825                 830         


Glu Thr Ile Arg His Ala Leu Gln Leu Ala Leu Asp Arg Arg Arg Gln 
        835                 840                 845             


Ala Gly Gly Arg Val Gly Gly 
    850                 855 


<210>  94
<211>  440
<212>  PRT
<213>  Mus musculus

<400>  94

Met Val Pro Leu Lys Leu Gln Ala Leu Phe Cys Leu Leu Cys Cys Leu 
1               5                   10                  15      


Pro Trp Val His Pro Phe His Trp Gln Asp Thr Ser Ser Phe Asp Phe 
            20                  25                  30          


Arg Pro Ser Val Met Phe His Lys Leu Gln Ser Val Met Ser Ala Ala 
        35                  40                  45              


Gly Ser Gly His Ser Lys Ile Pro Lys Gly Asn Gly Ser Tyr Pro Val 
    50                  55                  60                  


Gly Cys Thr Asp Leu Met Phe Gly Tyr Gly Asn Glu Ser Val Phe Val 
65                  70                  75                  80  


Arg Leu Tyr Tyr Pro Ala Gln Asp Gln Gly Arg Leu Asp Thr Val Trp 
                85                  90                  95      


Ile Pro Asn Lys Glu Tyr Phe Leu Gly Leu Ser Ile Phe Leu Gly Thr 
            100                 105                 110         


Pro Ser Ile Val Gly Asn Ile Leu His Leu Leu Tyr Gly Ser Leu Thr 
        115                 120                 125             


Thr Pro Ala Ser Trp Asn Ser Pro Leu Arg Thr Gly Glu Lys Tyr Pro 
    130                 135                 140                 


Leu Ile Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Ile Tyr Ser 
145                 150                 155                 160 


Ala Ile Gly Ile Gly Leu Ala Ser Asn Gly Phe Ile Val Ala Thr Val 
                165                 170                 175     


Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Phe Phe Glu Asp Gln 
            180                 185                 190         


Val Ala Ala Lys Val Glu Asn Arg Ser Trp Leu Tyr Leu Arg Lys Val 
        195                 200                 205             


Lys Gln Glu Glu Ser Glu Ser Val Arg Lys Glu Gln Val Gln Gln Arg 
    210                 215                 220                 


Ala Ile Glu Cys Ser Arg Ala Leu Ser Ala Ile Leu Asp Ile Glu His 
225                 230                 235                 240 


Gly Asp Pro Lys Glu Asn Val Leu Gly Ser Ala Phe Asp Met Lys Gln 
                245                 250                 255     


Leu Lys Asp Ala Ile Asp Glu Thr Lys Ile Ala Leu Met Gly His Ser 
            260                 265                 270         


Phe Gly Gly Ala Thr Val Leu Gln Ala Leu Ser Glu Asp Gln Arg Phe 
        275                 280                 285             


Arg Cys Gly Val Ala Leu Asp Pro Trp Met Tyr Pro Val Asn Glu Glu 
    290                 295                 300                 


Leu Tyr Ser Arg Thr Leu Gln Pro Leu Leu Phe Ile Asn Ser Ala Lys 
305                 310                 315                 320 


Phe Gln Thr Pro Lys Asp Ile Ala Lys Met Lys Lys Phe Tyr Gln Pro 
                325                 330                 335     


Asp Lys Glu Arg Lys Met Ile Thr Ile Lys Gly Ser Val His Gln Asn 
            340                 345                 350         


Phe Asp Asp Phe Thr Phe Val Thr Gly Lys Ile Ile Gly Asn Lys Leu 
        355                 360                 365             


Thr Leu Lys Gly Glu Ile Asp Ser Arg Val Ala Ile Asp Leu Thr Asn 
    370                 375                 380                 


Lys Ala Ser Met Ala Phe Leu Gln Lys His Leu Gly Leu Gln Lys Asp 
385                 390                 395                 400 


Phe Asp Gln Trp Asp Pro Leu Val Glu Gly Asp Asp Glu Asn Leu Ile 
                405                 410                 415     


Pro Gly Ser Pro Phe Asp Ala Val Thr Gln Val Pro Ala Gln Gln His 
            420                 425                 430         


Ser Pro Gly Ser Gln Thr Gln Asn 
        435                 440 


<210>  95
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Leu Ile Ala Thr Ser Phe Phe Leu Phe Phe Ser Ser Val Val Ala 
1               5                   10                  15      


Ala Pro Thr His Ser Ser Phe Trp Gln Phe Gln Arg Arg Val Lys His 
            20                  25                  30          


Ile Thr Gly Arg Ser Ala Phe Phe Ser Tyr Tyr Gly Tyr Gly Cys Tyr 
        35                  40                  45              


Cys Gly Leu Gly Asp Lys Gly Ile Pro Val Asp Asp Thr Asp Ser Pro 
    50                  55                  60                  


Ser Ser Pro Ser Pro Tyr Glu Lys Leu Lys Glu Phe Ser Cys Gln Pro 
65                  70                  75                  80  


Val Leu Asn Ser Tyr Gln Phe His Ile Val Asn Gly Ala Val Val Cys 
                85                  90                  95      


Gly Cys Thr Leu Gly Pro Gly Ala Ser Cys His Cys Arg Leu Lys Ala 
            100                 105                 110         


Cys Glu Cys Asp Lys Gln Ser Val His Cys Phe Lys Glu Ser Leu Pro 
        115                 120                 125             


Thr Tyr Glu Lys Asn Phe Lys Gln Phe Ser Ser Gln Pro Arg Cys Gly 
    130                 135                 140                 


Arg His Lys Pro Trp Cys 
145                 150 


<210>  96
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  97
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val Met Ala Gly Val Ile 
1               5                   10                  15      


Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys Met Val Lys Gln Val 
            20                  25                  30          


Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala Thr Asp Trp Cys Cys 
    50                  55                  60                  


Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys Thr Gln Gly Cys Ser 
65                  70                  75                  80  


Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser Gln Gly Asn Ile His 
                85                  90                  95      


Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln Leu Cys Ala Cys Asp 
            100                 105                 110         


Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu Asp Thr Tyr Gln Lys 
        115                 120                 125             


Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg Gly Gln Thr Pro Gly 
    130                 135                 140                 


Cys 
145 


<210>  98
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Lys Lys Phe Phe Thr Val Ala Ile Leu Ala Gly Ser Val Leu Ser 
1               5                   10                  15      


Thr Ala His Gly Ser Leu Leu Asn Leu Lys Ala Met Val Glu Ala Val 
            20                  25                  30          


Thr Gly Arg Ser Ala Ile Leu Ser Phe Val Gly Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Glu Val Asp Trp Cys Cys 
    50                  55                  60                  


His Ala His Asp Cys Cys Tyr Gln Glu Leu Phe Asp Gln Gly Cys His 
65                  70                  75                  80  


Pro Tyr Val Asp His Tyr Asp His Thr Ile Glu Asn Asn Thr Glu Ile 
                85                  90                  95      


Val Cys Ser Asp Leu Asn Lys Thr Glu Cys Asp Lys Gln Thr Cys Met 
            100                 105                 110         


Cys Asp Lys Asn Met Val Leu Cys Leu Met Asn Gln Thr Tyr Arg Glu 
        115                 120                 125             


Glu Tyr Arg Gly Phe Leu Asn Val Tyr Cys Gln Gly Pro Thr Pro Asn 
    130                 135                 140                 


Cys Ser Ile Tyr Glu Pro Pro Pro Glu Glu Val Thr Cys Ser His Gln 
145                 150                 155                 160 


Ser Pro Ala Pro Pro Ala Pro Pro 
                165             


<210>  99
<211>  124
<212>  PRT
<213>  Sus scrofa

<400>  99

Ala Leu Trp Gln Phe Arg Ser Met Ile Lys Cys Thr Ile Pro Gly Ser 
1               5                   10                  15      


Asp Pro Leu Leu Asp Phe Asn Asn Tyr Gly Cys Tyr Cys Gly Leu Gly 
            20                  25                  30          


Gly Ser Gly Thr Pro Val Asp Glu Leu Asp Arg Cys Cys Glu Thr His 
        35                  40                  45              


Asp Asn Cys Tyr Arg Asp Ala Lys Asn Leu Asp Ser Cys Lys Phe Leu 
    50                  55                  60                  


Val Asp Asn Pro Tyr Thr Asn Ser Tyr Ser Tyr Ser Cys Ser Asn Thr 
65                  70                  75                  80  


Glu Ile Thr Cys Asn Ser Lys Asn Asn Ala Cys Glu Ala Phe Ile Cys 
                85                  90                  95      


Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe Ser Lys Ala Pro Tyr Asn 
            100                 105                 110         


Lys Glu His Lys Asn Leu Asp Thr Lys Lys Tyr Cys 
        115                 120                 


<210>  100
<211>  791
<212>  PRT
<213>  Mus musculus

<400>  100

Met Ala Leu Gln Thr Cys Pro Val Tyr Met Gln Ala Lys Val Pro Glu 
1               5                   10                  15      


Thr Cys Leu Leu Thr Val Arg Val Leu Arg Ala Ser Gly Leu Pro Ser 
            20                  25                  30          


Lys Asp Leu Val Thr Ser Ser Asp Cys Tyr Val Thr Leu Asn Leu Pro 
        35                  40                  45              


Thr Ala Ser Ser His Thr Leu Gln Thr Arg Thr Val Lys Asn Ser Arg 
    50                  55                  60                  


Asn Pro Val Trp Asn Gln Asn Phe His Phe Arg Ile His Arg Gln Leu 
65                  70                  75                  80  


Lys Asn Val Met Glu Leu Lys Val Phe Asp His Asp Leu Val Thr Arg 
                85                  90                  95      


Asp Asp Pro Val Leu Ser Val Leu Phe Asp Val Gly Thr Leu Gln Ile 
            100                 105                 110         


Gly Thr Gln Arg Gln Ser Phe Ser Leu Gly Thr Gln Glu Lys Gly Cys 
        115                 120                 125             


Leu Glu Val Glu Phe Arg Leu Gln Thr Leu Thr Asp Cys Glu Glu Gln 
    130                 135                 140                 


Leu Ile Ser Asn Gly Ile Val Val Ala Arg Glu Leu Ser Cys Leu His 
145                 150                 155                 160 


Val Glu Leu Lys Arg Thr Gly Asp Pro Lys Arg Ser Glu Arg Lys Val 
                165                 170                 175     


Gln Leu Val Val Ala Gly Ala Cys Glu Gly Pro Gln Asp Ala Ser Ala 
            180                 185                 190         


Gly Thr Gly Ser Phe His Phe His Tyr Pro Ala Cys Trp Glu Gln Glu 
        195                 200                 205             


Leu Asn Val His Leu Gln Asp Asp Pro His Glu Gln Leu Lys Val Pro 
    210                 215                 220                 


Leu Arg Thr Leu Pro Ser Ser Gln Leu Val Arg Leu Val Phe Pro Thr 
225                 230                 235                 240 


Ser Gln Glu Pro Leu Met Arg Leu Glu Leu Lys Lys Glu Glu Gly Pro 
                245                 250                 255     


Lys Glu Leu Ala Val Arg Leu Gly Cys Gly Pro Cys Pro Glu Glu Gln 
            260                 265                 270         


Ala Phe Leu Ser Lys Arg Lys Gln Val Val Ala Ala Ala Leu Lys Lys 
        275                 280                 285             


Ala Leu Gln Leu Asp Gln Asp Leu His Glu Asp Glu Ile Pro Val Ile 
    290                 295                 300                 


Ala Val Met Ala Thr Gly Gly Gly Ile Arg Ala Met Thr Ser Leu Tyr 
305                 310                 315                 320 


Gly Gln Leu Ala Gly Leu Gln Glu Leu Gly Leu Leu Asp Cys Ile Ser 
                325                 330                 335     


Tyr Ile Thr Gly Ala Ser Gly Ser Thr Trp Ala Leu Ala Asn Leu Tyr 
            340                 345                 350         


Glu Asp Pro Glu Trp Ser Gln Lys Asp Leu Ala Gly Pro Thr Glu Val 
        355                 360                 365             


Leu Lys Thr Gln Val Thr Lys Ser Lys Leu Gly Ala Leu Ala Pro Ser 
    370                 375                 380                 


Gln Leu Trp Arg Tyr Arg Gln Glu Leu Ala Glu Arg Ala Arg Leu Gly 
385                 390                 395                 400 


His Pro Thr Cys Phe Thr Asn Leu Trp Ala Leu Ile Asn Glu Ala Leu 
                405                 410                 415     


Leu His Asp Lys Pro His Glu His Lys Leu Ser Asp Gln Arg Glu Ala 
            420                 425                 430         


Leu Ser Arg Gly Gln Asn Pro Leu Pro Ile Tyr Cys Ala Leu Asn Ser 
        435                 440                 445             


Lys Glu Gln Gly Leu Ser Thr Phe Asp Phe Gly Glu Trp Cys Glu Phe 
    450                 455                 460                 


Ser Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala Phe Ile Ser Ser 
465                 470                 475                 480 


Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Arg Leu Val Lys Gln Leu 
                485                 490                 495     


Pro Glu Ser Arg Ile Cys Phe Leu Glu Gly Ile Trp Ser Asn Leu Phe 
            500                 505                 510         


Ala Ala Ser Leu Gln Asp Ser Leu Tyr Trp Ser Ser Glu Pro Ser Gln 
        515                 520                 525             


Phe Trp Asp Arg Trp Ala Gln Asp Gln Ala Asn Leu Asp Lys Glu Gln 
    530                 535                 540                 


Val Pro His Leu Lys Ile Ala Glu Pro Pro Thr Met Ala Gly Arg Ile 
545                 550                 555                 560 


Ala Glu Leu Phe Thr Asp Leu Leu Thr Lys Arg Pro Leu Ala His Ala 
                565                 570                 575     


Thr His Asn Phe Thr Arg Gly Leu His Phe His Lys Asp Tyr Phe Gln 
            580                 585                 590         


Asn Ser His Phe Ser Ala Trp Lys Ala Ser Lys Leu Asp Arg Leu Pro 
        595                 600                 605             


Asn Gln Leu Thr Pro Thr Glu Pro His Leu Cys Leu Leu Asp Val Gly 
    610                 615                 620                 


Tyr Leu Ile Asn Thr Ser Cys Pro Pro Leu Leu Gln Pro Thr Arg Asp 
625                 630                 635                 640 


Val Asp Leu Ile Leu Ser Leu Asp Tyr Asn Leu Tyr Gly Ala Phe Gln 
                645                 650                 655     


Gln Leu Gln Leu Leu Ser Arg Phe Cys Gln Glu Gln Gly Ile Pro Phe 
            660                 665                 670         


Pro Ser Ile Ser Pro Ser Pro Glu Glu Gln Arg Gln Pro Gln Glu Cys 
        675                 680                 685             


His Leu Phe Cys Asp Pro Ala Gln Pro Glu Ala Pro Ala Val Leu His 
    690                 695                 700                 


Phe Pro Leu Val Asn Asp Ser Phe Gln Asp Tyr Ser Ala Pro Gly Val 
705                 710                 715                 720 


Pro Arg Thr Ser Glu Glu Lys Ala Ala Gly Glu Val Asn Leu Ser Ser 
                725                 730                 735     


Ser Asp Ser Pro Tyr His Tyr Thr Lys Val Thr Tyr Ser Gln Glu Asp 
            740                 745                 750         


Val Asp Lys Leu Leu Arg Leu Thr His Tyr Asn Ile Cys Asn Asn Gln 
        755                 760                 765             


Asp Arg Leu Arg Glu Ala Met His Gln Ala Val Gln Arg Arg Arg Lys 
    770                 775                 780                 


Arg Lys Gln Phe Arg Pro Glu 
785                 790     


<210>  101
<211>  224
<212>  PRT
<213>  Rattus norvegicus

<400>  101

Met Pro Gly Gly Leu Leu Leu Gly Asp Glu Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Ile Gly His Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Phe 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Gly Ala Ala Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Lys Asp Arg Asp Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Ile Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Asp Ser Leu Gln Leu Thr Ala Ser Asn Pro Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Lys Gly Glu Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Leu Pro Glu Glu Glu Ala Lys Gln Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  102
<211>  224
<212>  PRT
<213>  Bos taurus

<400>  102

Met Pro Gly Gly Leu Leu Leu Gly Asp Glu Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Ile Gly Arg Ile Arg Phe His Asp Tyr Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Met Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Gly Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Lys Asn Arg Asp Leu Ala Ile 
            100                 105                 110         


Gln Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Ile Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Ile Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asn Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  103
<211>  1463
<212>  PRT
<213>  Bos taurus

<400>  103

Met Pro Leu Leu Ser Leu Ser Leu Leu Leu Leu Leu Leu Gln Val Pro 
1               5                   10                  15      


Ala Gly Ser Ala Glu Thr Ala Ala Trp Ala Val Thr Pro Glu Arg Leu 
            20                  25                  30          


Arg Glu Trp Gln Asp Lys Gly Ile Phe Ile Ile Gln Ser Glu Asn Leu 
        35                  40                  45              


Glu Lys Cys Ile Gln Ala Ser Lys Ser Thr Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Pro Pro Asn Lys Tyr Met Leu Trp Lys Trp Val Ser Asn His Arg 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Val Ser Ser 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Ile Tyr Glu Cys Asp Ser Thr His Val Ser 
            100                 105                 110         


Leu Lys Trp His Cys Asn Lys Lys Thr Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Leu Val Gln Val Lys Gln Asp Asn Thr Leu Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Leu His Lys Trp Val Ser Tyr Met Ser Gly Gly Gly Gly Ile Cys Asp 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu Tyr Thr Ile Lys Gly Asn Ala His Gly Thr 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn Gln Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asn Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Thr Glu Val Gly Cys Asp Ala Val Trp Glu Lys Asp Leu His Ser Arg 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Ala Ala Leu Leu Ser Ile Ala Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Val Arg Lys His Leu Gly Ser Glu Ala Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Arg Thr Pro Leu Asn Tyr Leu Asn Trp Lys Pro Glu Ile 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Tyr His Cys Gly Thr Phe Asn Ala Phe 
                325                 330                 335     


Met Pro Lys Ala Trp Lys Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Val Cys Lys Lys Tyr Leu Asn Pro Thr Asp His Gly Val Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


His Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Lys Lys Thr Trp Asn 
385                 390                 395                 400 


Glu Ala Leu Gln Ser Cys Gln Ser Asn Asn Ser Val Leu Thr Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser His Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Gly Ser Ser Val Thr Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Thr 
                485                 490                 495     


Leu Phe Tyr Leu Cys Lys Lys Thr Gly Leu Val Leu Ser Asp Thr Glu 
            500                 505                 510         


Ser Gly Cys Gln Lys Gly Trp Glu Arg His Gly Lys Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp His Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Ile Thr Ile Thr Ser Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Thr Lys Asp Thr Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Thr Ala Gly Gln Gln Leu Glu Pro Val Lys Tyr Thr His Trp Asn Thr 
        595                 600                 605             


Arg Gln Pro Arg Tyr Ser Gly Gly Cys Val Val Met Arg Gly Arg Ser 
    610                 615                 620                 


His Pro Gly Arg Trp Glu Val Arg Asp Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Arg Glu Lys Thr Lys Gln Glu 
                645                 650                 655     


Glu Gly Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Gln Ala Glu Glu Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Arg Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Gly Thr Pro Val Val Ser Ser Phe Leu Asp Asn Ser Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Ser Tyr Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Arg Pro Lys Val Pro Pro Trp Tyr Gln Tyr Asp Ala Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Ile Ser Ala Ser Glu 
            820                 825                 830         


Trp Ser Ser Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Ile Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Arg 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Val Asn Trp Trp Ile Gly Leu Arg Glu Glu 
865                 870                 875                 880 


Arg Ala Ser Asp Glu Phe Arg Trp Arg Asp Gly Ser Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Lys Gly Lys Glu Arg Ser Met Gly Leu Asn Glu Ser 
            900                 905                 910         


Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Ala Ser Glu 
        915                 920                 925             


Glu Cys Ser Ile Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp 
    930                 935                 940                 


Val Ile Glu Lys Lys Lys Asp Ile Pro Lys Gln His Gly Thr Cys Pro 
945                 950                 955                 960 


Lys Gly Trp Leu Tyr Phe Asp Tyr Lys Cys Leu Leu Leu Lys Ile Pro 
                965                 970                 975     


Glu Gly Pro Ser Asp Trp Lys Asn Trp Thr Ser Ala Gln Asp Phe Cys 
            980                 985                 990         


Val Glu Glu Gly Gly Thr Leu Val  Ala Ile Glu Asn Glu  Val Glu Gln 
        995                 1000                 1005             


Ala Phe  Ile Thr Met Asn Leu  Phe Gly His Thr Thr  Asn Val Trp 
    1010                 1015                 1020             


Ile Gly  Leu Gln Asp Asp Asp  Tyr Glu Lys Trp Leu  Asn Gly Arg 
    1025                 1030                 1035             


Pro Val  Ser Tyr Ser Asn Trp  Ser Pro Phe Asp Thr  Lys Asn Ile 
    1040                 1045                 1050             


Pro Asn  His Asn Thr Thr Glu  Val Gln Lys Arg Ile  Pro Leu Cys 
    1055                 1060                 1065             


Gly Leu  Leu Ser Asn Asn Pro  Asn Phe His Phe Thr  Gly Lys Trp 
    1070                 1075                 1080             


Tyr Phe  Glu Asp Cys Arg Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Ala Ser Gly His  Ser Ile Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Ile  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Thr Ala Leu Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Gly Ala Glu Leu Ala  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Ile Leu  Asn Arg Val Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Glu Asp  Asn Gly Leu Ser Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Asp Glu Ser 
    1190                 1195                 1200             


Ser Phe  Leu Gly Asp Cys Val  Phe Ala Asp Thr Ser  Gly Arg Trp 
    1205                 1210                 1215             


Ser Ser  Thr Ala Cys Glu Ser  Tyr Leu Gln Gly Ala  Ile Cys Gln 
    1220                 1225                 1230             


Val Pro  Thr Glu Thr Arg Leu  Ser Gly Arg Leu Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Glu Ser  Thr Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Lys Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ser Phe Leu Leu  Glu Glu Leu Leu Ala  Phe Arg Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Ile Trp Leu  Asn Ala Gln Phe Asp  Gly Asp Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Glu  Val Tyr His Phe Lys  Pro His Leu 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Val Trp Gln  Leu Ser Ser 
    1355                 1360                 1365             


Cys Gln  Asp Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Val Lys Lys His Pro  Gly Lys Gly Pro Ser  His Ser Val 
    1385                 1390                 1395             


Ile Pro  Leu Thr Val Ala Leu  Thr Leu Leu Val Ile  Leu Ala Ile 
    1400                 1405                 1410             


Ser Thr  Leu Ser Phe Cys Met  Tyr Lys His Ser His  Ile Ile Phe 
    1415                 1420                 1425             


Gly Arg  Leu Ala Gln Phe Arg  Asn Pro Tyr Tyr Pro  Ser Ala Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val His Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Asn Asp Gln 
    1460             


<210>  104
<211>  855
<212>  PRT
<213>  Mus musculus

<400>  104

Met Pro Trp Thr Leu Gln Pro Lys Trp Leu Ala Gly Lys Gly Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ala Ile Leu Leu Arg Lys Thr Glu Lys Ser Glu Pro Gln 
            20                  25                  30          


Trp Lys His Arg Arg Gln Glu Thr His Pro Tyr Tyr Asp Leu Gln Val 
        35                  40                  45              


Lys Val Leu Gly Ala Arg Asn Ile Gln His Thr Asp Lys Leu Ser Lys 
    50                  55                  60                  


Ala Asp Cys Tyr Val Arg Leu Trp Leu Pro Thr Ala Ser Val Ser Pro 
65                  70                  75                  80  


Ser Gln Thr Arg Thr Val Val Asn Ser Ser Asp Pro Glu Trp Asn Glu 
                85                  90                  95      


Thr Phe His Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu 
            100                 105                 110         


Ala Leu Tyr Asp Glu Asp Val Leu Asp Ser Asp Asn Val Phe Ser Ile 
        115                 120                 125             


Leu Phe Asp Met Ser Thr Leu Gln Leu Gly Gln Pro Cys Thr Lys Asn 
    130                 135                 140                 


Phe Thr Arg Gln Gln Asp Pro Lys Glu Leu Glu Val Glu Phe Thr Leu 
145                 150                 155                 160 


Glu Lys Ser Gln Thr Pro Ala Ser Glu Val Val Thr Asn Gly Val Leu 
                165                 170                 175     


Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Val Thr Gly Asp Lys 
            180                 185                 190         


Thr Ala Ser Leu Gly Glu Leu Gly Ser Arg Gln Ile Gln Leu Ala Val 
        195                 200                 205             


Pro Gly Ala Tyr Glu Lys Pro Gln Pro Leu Gln Pro Thr Ser Glu Pro 
    210                 215                 220                 


Gly Leu Pro Val Asn Phe Thr Phe His Met Asn Pro Val Leu Ser Pro 
225                 230                 235                 240 


Lys Leu His Ile Lys Leu Gln Glu Gln Leu Gln Val Phe His Ser Gly 
                245                 250                 255     


Pro Ser Asp Glu Leu Glu Ala Gln Thr Ser Lys Met Asp Lys Ala Ser 
            260                 265                 270         


Ile Leu Leu Ser Ser Leu Pro Leu Asn Glu Glu Leu Thr Lys Leu Val 
        275                 280                 285             


Asp Leu Glu Glu Gly Gln Gln Val Thr Leu Arg Met Lys Ala Asp Met 
    290                 295                 300                 


Ser Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu Cys Asp 
305                 310                 315                 320 


Gly Glu Gln Glu Phe Leu Asp Lys Arg Lys Gln Val Ala Ser Lys Ala 
                325                 330                 335     


Leu Gln Arg Ala Met Gly Leu Ser Glu Ala Leu His Cys Asp Gln Val 
            340                 345                 350         


Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala Met Thr 
        355                 360                 365             


Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Pro Leu Asp 
    370                 375                 380                 


Ala Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Ser Trp Cys Ile Ser 
385                 390                 395                 400 


Thr Leu Tyr Arg Asp Pro Ser Trp Ser Gln Lys Ala Leu Gln Gly Pro 
                405                 410                 415     


Ile Lys Tyr Ala Ser Glu Arg Val Cys Ser Ser Lys Ile Gly Met Leu 
            420                 425                 430         


Ser Pro Lys Gln Phe Glu Tyr Tyr Ser Arg Glu Lys Arg Ala Trp Glu 
        435                 440                 445             


Ser Arg Gly His Ser Met Ser Phe Thr Asp Leu Trp Gly Leu Ile Ile 
    450                 455                 460                 


Glu Tyr Phe Leu Asn Gln Glu Glu Asn Pro Ala Lys Leu Ser Asp Gln 
465                 470                 475                 480 


Gln Glu Thr Val Ser Gln Gly Gln Asn Pro Tyr Pro Ile Tyr Ala Ser 
                485                 490                 495     


Ile Asn Val His Lys Asn Ile Ser Gly Asp Asp Phe Ala Glu Trp Cys 
            500                 505                 510         


Glu Phe Thr Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala Tyr Val 
        515                 520                 525             


Pro Thr Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Arg Leu Leu His 
    530                 535                 540                 


Phe Trp Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Arg Gly Ser 
545                 550                 555                 560 


Ala Phe Ala Ala Ser Leu Tyr Gly Ile Phe Leu Lys Leu Gly Gly Leu 
                565                 570                 575     


Ser Leu Ser Phe Leu Asp Trp His Arg Gly Ser Val Ser Val Thr Asp 
            580                 585                 590         


Asp Trp Pro Lys Leu Arg Lys Gln Asp Pro Thr Arg Leu Pro Thr Arg 
        595                 600                 605             


Leu Phe Thr Pro Met Ser Ser Phe Ser Gln Ala Val Leu Asp Ile Phe 
    610                 615                 620                 


Thr Ser Arg Ile Thr Cys Ala Gln Thr Phe Asn Phe Thr Arg Gly Leu 
625                 630                 635                 640 


Cys Met Tyr Lys Asp Tyr Thr Ala Arg Lys Asp Phe Val Val Ser Glu 
                645                 650                 655     


Asp Ala Trp His Ser His Asn Tyr Gly Tyr Pro Asp Ala Cys Pro Asn 
            660                 665                 670         


Gln Leu Thr Pro Met Lys Asp Phe Leu Ser Leu Val Asp Gly Gly Phe 
        675                 680                 685             


Ala Ile Asn Ser Pro Phe Pro Leu Val Leu Gln Pro Gln Arg Ala Val 
    690                 695                 700                 


Asp Leu Ile Val Ser Phe Asp Tyr Ser Leu Glu Gly Pro Phe Glu Val 
705                 710                 715                 720 


Leu Gln Val Thr Glu Lys Tyr Cys Arg Asp Arg Gly Ile Pro Phe Pro 
                725                 730                 735     


Arg Ile Glu Val Asp Pro Lys Asp Ser Glu Asp Pro Arg Glu Cys Tyr 
            740                 745                 750         


Leu Phe Thr Glu Ala Glu Asp Pro Cys Ser Pro Ile Val Leu His Phe 
        755                 760                 765             


Pro Leu Val Asn Arg Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu 
    770                 775                 780                 


Arg Gln Thr Ala Glu Glu Lys Ala Phe Glu Asp Phe Ile Ile Asn Gly 
785                 790                 795                 800 


Pro Asp Thr Ala Tyr Gly Met Met Asp Phe Thr Tyr Glu Pro Lys Glu 
                805                 810                 815     


Phe Asp Arg Leu Val Thr Leu Ser Arg Tyr Asn Val Leu Asn Asn Lys 
            820                 825                 830         


Glu Thr Ile Arg His Ala Leu Gln Leu Ala Leu Asp Arg Arg Arg Gln 
        835                 840                 845             


Ala Gly Gly Arg Val Gly Gly 
    850                 855 


<210>  105
<211>  782
<212>  PRT
<213>  Mus musculus

<400>  105

Met Gln Ala Lys Val Pro Glu Thr Cys Leu Leu Thr Val Arg Val Leu 
1               5                   10                  15      


Arg Ala Ser Gly Leu Pro Ser Lys Asp Leu Val Thr Ser Ser Asp Cys 
            20                  25                  30          


Tyr Val Thr Leu Asn Leu Pro Thr Ala Ser Ser His Thr Leu Gln Thr 
        35                  40                  45              


Arg Thr Val Lys Asn Ser Arg Asn Pro Val Trp Asn Gln Asn Phe His 
    50                  55                  60                  


Phe Arg Ile His Arg Gln Leu Lys Asn Val Met Glu Leu Lys Val Phe 
65                  70                  75                  80  


Asp His Asp Leu Val Thr Arg Asp Asp Pro Val Leu Ser Val Leu Phe 
                85                  90                  95      


Asp Val Gly Thr Leu Gln Ile Gly Thr Gln Arg Gln Ser Phe Ser Leu 
            100                 105                 110         


Gly Thr Gln Glu Lys Gly Cys Leu Glu Val Glu Phe Arg Leu Gln Thr 
        115                 120                 125             


Leu Thr Asp Cys Glu Glu Gln Leu Ile Ser Asn Gly Ile Val Val Ala 
    130                 135                 140                 


Arg Glu Leu Ser Cys Leu His Val Glu Leu Lys Arg Thr Gly Asp Pro 
145                 150                 155                 160 


Lys Arg Ser Glu Arg Lys Val Gln Leu Val Val Ala Gly Ala Cys Glu 
                165                 170                 175     


Gly Pro Gln Asp Ala Ser Ala Gly Thr Gly Ser Phe His Phe His Tyr 
            180                 185                 190         


Pro Ala Cys Trp Glu Gln Glu Leu Asn Val His Leu Gln Asp Asp Pro 
        195                 200                 205             


His Glu Gln Leu Lys Val Pro Leu Arg Thr Leu Pro Ser Ser Gln Leu 
    210                 215                 220                 


Val Arg Leu Val Phe Pro Thr Ser Gln Glu Pro Leu Met Arg Leu Glu 
225                 230                 235                 240 


Leu Lys Lys Glu Glu Gly Pro Lys Glu Leu Ala Val Arg Leu Gly Cys 
                245                 250                 255     


Gly Pro Cys Pro Glu Glu Gln Ala Phe Leu Ser Lys Arg Lys Gln Val 
            260                 265                 270         


Val Ala Ala Ala Leu Lys Lys Ala Leu Gln Leu Asp Gln Asp Leu His 
        275                 280                 285             


Glu Asp Glu Ile Pro Val Ile Ala Val Met Ala Thr Gly Gly Gly Ile 
    290                 295                 300                 


Arg Ala Met Thr Ser Leu Tyr Gly Gln Leu Ala Gly Leu Gln Glu Leu 
305                 310                 315                 320 


Gly Leu Leu Asp Cys Ile Ser Tyr Ile Thr Gly Ala Ser Gly Ser Thr 
                325                 330                 335     


Trp Ala Leu Ala Asn Leu Tyr Glu Asp Pro Glu Trp Ser Gln Lys Asp 
            340                 345                 350         


Leu Ala Gly Pro Thr Glu Val Leu Lys Thr Gln Val Thr Lys Ser Lys 
        355                 360                 365             


Leu Gly Ala Leu Ala Pro Ser Gln Leu Trp Arg Tyr Arg Gln Glu Leu 
    370                 375                 380                 


Ala Glu Arg Ala Arg Leu Gly His Pro Thr Cys Phe Thr Asn Leu Trp 
385                 390                 395                 400 


Ala Leu Ile Asn Glu Ala Leu Leu His Asp Lys Pro His Glu His Lys 
                405                 410                 415     


Leu Ser Asp Gln Arg Glu Ala Leu Ser Arg Gly Gln Asn Pro Leu Pro 
            420                 425                 430         


Ile Tyr Cys Ala Leu Asn Ser Lys Glu Gln Gly Leu Ser Thr Phe Asp 
        435                 440                 445             


Phe Gly Glu Trp Cys Glu Phe Ser Pro Tyr Glu Val Gly Phe Pro Lys 
    450                 455                 460                 


Tyr Gly Ala Phe Ile Ser Ser Glu Leu Phe Gly Ser Glu Phe Phe Met 
465                 470                 475                 480 


Gly Arg Leu Val Lys Gln Leu Pro Glu Ser Arg Ile Cys Phe Leu Glu 
                485                 490                 495     


Gly Ile Trp Ser Asn Leu Phe Ala Ala Ser Leu Gln Asp Ser Leu Tyr 
            500                 505                 510         


Trp Ser Ser Glu Pro Ser Gln Phe Trp Asp Arg Trp Ala Gln Asp Gln 
        515                 520                 525             


Ala Asn Leu Asp Lys Glu Gln Val Pro His Leu Lys Ile Ala Glu Pro 
    530                 535                 540                 


Pro Thr Met Ala Gly Arg Ile Ala Glu Leu Phe Thr Asp Leu Leu Thr 
545                 550                 555                 560 


Lys Arg Pro Leu Ala His Ala Thr His Asn Phe Thr Arg Gly Leu His 
                565                 570                 575     


Phe His Lys Asp Tyr Phe Gln Asn Ser His Phe Ser Ala Trp Lys Ala 
            580                 585                 590         


Ser Lys Leu Asp Arg Leu Pro Asn Gln Leu Thr Pro Thr Glu Pro His 
        595                 600                 605             


Leu Cys Leu Leu Asp Val Gly Tyr Leu Ile Asn Thr Ser Cys Pro Pro 
    610                 615                 620                 


Leu Leu Gln Pro Thr Arg Asp Val Asp Leu Ile Leu Ser Leu Asp Tyr 
625                 630                 635                 640 


Asn Leu Tyr Gly Ala Phe Gln Gln Leu Gln Leu Leu Ser Arg Phe Cys 
                645                 650                 655     


Gln Glu Gln Gly Ile Pro Phe Pro Ser Ile Ser Pro Ser Pro Glu Glu 
            660                 665                 670         


Gln Arg Gln Pro Gln Glu Cys His Leu Phe Cys Asp Pro Ala Gln Pro 
        675                 680                 685             


Glu Ala Pro Ala Val Leu His Phe Pro Leu Val Asn Asp Ser Phe Gln 
    690                 695                 700                 


Asp Tyr Ser Ala Pro Gly Val Pro Arg Thr Ser Glu Glu Lys Ala Ala 
705                 710                 715                 720 


Gly Glu Val Asn Leu Ser Ser Ser Asp Ser Pro Tyr His Tyr Thr Lys 
                725                 730                 735     


Val Thr Tyr Ser Gln Glu Asp Val Asp Lys Leu Leu Arg Leu Thr His 
            740                 745                 750         


Tyr Asn Ile Cys Asn Asn Gln Asp Arg Leu Arg Glu Ala Met His Gln 
        755                 760                 765             


Ala Val Gln Arg Arg Arg Lys Arg Lys Gln Phe Arg Pro Glu 
    770                 775                 780         


<210>  106
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ala Glu Ala Ala Leu Glu Ala Val Arg Ser Glu Leu Arg Glu Phe 
1               5                   10                  15      


Pro Ala Ala Ala Arg Glu Leu Cys Val Pro Leu Ala Val Pro Tyr Leu 
            20                  25                  30          


Asp Lys Pro Pro Thr Pro Leu His Phe Tyr Arg Asp Trp Val Cys Pro 
        35                  40                  45              


Asn Arg Pro Cys Ile Ile Arg Asn Ala Leu Gln His Trp Pro Ala Leu 
    50                  55                  60                  


Gln Lys Trp Ser Leu Pro Tyr Phe Arg Ala Thr Val Gly Ser Thr Glu 
65                  70                  75                  80  


Val Ser Val Ala Val Thr Pro Asp Gly Tyr Ala Asp Ala Val Arg Gly 
                85                  90                  95      


Asp Arg Phe Met Met Pro Ala Glu Arg Arg Leu Pro Leu Ser Phe Val 
            100                 105                 110         


Leu Asp Val Leu Glu Gly Arg Ala Gln His Pro Gly Val Leu Tyr Val 
        115                 120                 125             


Gln Lys Gln Cys Ser Asn Leu Pro Ser Glu Leu Pro Gln Leu Leu Pro 
    130                 135                 140                 


Asp Leu Glu Ser His Val Pro Trp Ala Ser Glu Ala Leu Gly Lys Met 
145                 150                 155                 160 


Pro Asp Ala Val Asn Phe Trp Leu Gly Glu Ala Ala Ala Val Thr Ser 
                165                 170                 175     


Leu His Lys Asp His Tyr Glu Asn Leu Tyr Cys Val Val Ser Gly Glu 
            180                 185                 190         


Lys His Phe Leu Phe His Pro Pro Ser Asp Arg Pro Phe Ile Pro Tyr 
        195                 200                 205             


Glu Leu Tyr Thr Pro Ala Thr Tyr Gln Leu Thr Glu Glu Gly Thr Phe 
    210                 215                 220                 


Lys Val Val Asp Glu Glu Ala Met Glu Lys Ala Glu Val Ser Arg Thr 
225                 230                 235                 240 


Cys Leu Leu Thr Val Arg Val Leu Gln Ala His Arg Leu Pro Ser Lys 
                245                 250                 255     


Asp Leu Val Thr Pro Ser Asp Cys Tyr Val Thr Leu Trp Leu Pro Thr 
            260                 265                 270         


Ala Cys Ser His Arg Leu Gln Thr Arg Thr Val Lys Asn Ser Ser Ser 
        275                 280                 285             


Pro Val Trp Asn Gln Ser Phe His Phe Arg Ile His Arg Gln Leu Lys 
    290                 295                 300                 


Asn Val Met Glu Leu Lys Val Phe Asp Gln Asp Leu Val Thr Gly Asp 
305                 310                 315                 320 


Asp Pro Val Leu Ser Val Leu Phe Asp Ala Gly Thr Leu Arg Ala Gly 
                325                 330                 335     


Glu Phe Arg Arg Glu Ser Phe Ser Leu Ser Pro Gln Gly Glu Gly Arg 
            340                 345                 350         


Leu Glu Val Glu Phe Arg Leu Gln Ser Leu Ala Asp Arg Gly Glu Trp 
        355                 360                 365             


Leu Val Ser Asn Gly Val Leu Val Ala Arg Glu Leu Ser Cys Leu His 
    370                 375                 380                 


Val Gln Leu Glu Glu Thr Gly Asp Pro Lys Ser Ser Glu His Arg Val 
385                 390                 395                 400 


Gln Leu Val Val Pro Gly Ser Cys Glu Gly Pro Gln Glu Ala Ser Val 
                405                 410                 415     


Gly Thr Gly Thr Phe Arg Phe His Cys Pro Ala Cys Trp Glu Gln Glu 
            420                 425                 430         


Leu Ser Ile Arg Leu Gln Asp Ala Pro Glu Glu Gln Leu Lys Ala Pro 
        435                 440                 445             


Leu Ser Ala Leu Pro Ser Gly Gln Val Val Arg Leu Val Phe Pro Thr 
    450                 455                 460                 


Ser Gln Glu Pro Leu Met Arg Val Glu Leu Lys Lys Glu Ala Gly Leu 
465                 470                 475                 480 


Arg Glu Leu Ala Val Arg Leu Gly Phe Gly Pro Cys Ala Glu Glu Gln 
                485                 490                 495     


Ala Phe Leu Ser Arg Arg Lys Gln Val Val Ala Ala Ala Leu Arg Gln 
            500                 505                 510         


Ala Leu Gln Leu Asp Gly Asp Leu Gln Glu Asp Glu Ile Pro Val Val 
        515                 520                 525             


Ala Ile Met Ala Thr Gly Gly Gly Ile Arg Ala Met Thr Ser Leu Tyr 
    530                 535                 540                 


Gly Gln Leu Ala Gly Leu Lys Glu Leu Gly Leu Leu Asp Cys Val Ser 
545                 550                 555                 560 


Tyr Ile Thr Gly Ala Ser Gly Ser Thr Trp Ala Leu Ala Asn Leu Tyr 
                565                 570                 575     


Glu Asp Pro Glu Trp Ser Gln Lys Asp Leu Ala Gly Pro Thr Glu Leu 
            580                 585                 590         


Leu Lys Thr Gln Val Thr Lys Asn Lys Leu Gly Val Leu Ala Pro Ser 
        595                 600                 605             


Gln Leu Gln Arg Tyr Arg Gln Glu Leu Ala Glu Arg Ala Arg Leu Gly 
    610                 615                 620                 


Tyr Pro Ser Cys Phe Thr Asn Leu Trp Ala Leu Ile Asn Glu Ala Leu 
625                 630                 635                 640 


Leu His Asp Glu Pro His Asp His Lys Leu Ser Asp Gln Arg Glu Ala 
                645                 650                 655     


Leu Ser His Gly Gln Asn Pro Leu Pro Ile Tyr Cys Ala Leu Asn Thr 
            660                 665                 670         


Lys Gly Gln Ser Leu Thr Thr Phe Glu Phe Gly Glu Trp Cys Glu Phe 
        675                 680                 685             


Ser Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala Phe Ile Pro Ser 
    690                 695                 700                 


Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Gln Leu Met Lys Arg Leu 
705                 710                 715                 720 


Pro Glu Ser Arg Ile Cys Phe Leu Glu Gly Ile Trp Ser Asn Leu Tyr 
                725                 730                 735     


Ala Ala Asn Leu Gln Asp Ser Leu Tyr Trp Ala Ser Glu Pro Ser Gln 
            740                 745                 750         


Phe Trp Asp Arg Trp Val Arg Asn Gln Ala Asn Leu Asp Lys Glu Gln 
        755                 760                 765             


Val Pro Leu Leu Lys Ile Glu Glu Pro Pro Ser Thr Ala Gly Arg Ile 
    770                 775                 780                 


Ala Glu Phe Phe Thr Asp Leu Leu Thr Trp Arg Pro Leu Ala Gln Ala 
785                 790                 795                 800 


Thr His Asn Phe Leu Arg Gly Leu His Phe His Lys Asp Tyr Phe Gln 
                805                 810                 815     


His Pro His Phe Ser Thr Trp Lys Ala Thr Thr Leu Asp Gly Leu Pro 
            820                 825                 830         


Asn Gln Leu Thr Pro Ser Glu Pro His Leu Cys Leu Leu Asp Val Gly 
        835                 840                 845             


Tyr Leu Ile Asn Thr Ser Cys Leu Pro Leu Leu Gln Pro Thr Arg Asp 
    850                 855                 860                 


Val Asp Leu Ile Leu Ser Leu Glu Ala Leu Arg Gln Ala Val Gln Arg 
865                 870                 875                 880 


Arg Arg Gln Arg Arg Pro His 
                885         


<210>  107
<211>  752
<212>  PRT
<213>  Rattus norvegicus

<400>  107

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Thr Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Pro Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Ile Leu Glu Met Ser Leu Glu Val Ser Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu Asn Ile Lys Glu Asn Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Lys Ser Glu Gly Leu Tyr Ser Thr Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Leu Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


Gln Asn Arg Ile Val Pro Thr Leu Ser Ser Leu Lys Glu Lys Val Ser 
305                 310                 315                 320 


Ala Ala Arg Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Thr Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Leu Gln Asn Lys Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Ala Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ala Gln Gly Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Glu Arg Glu Tyr Gln Asn Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Val His Arg Met Leu Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Arg Asp Phe Ser Pro 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Thr Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Val Glu Lys Asp Cys Thr Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Leu 
                645                 650                 655     


Arg Glu Thr Lys Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met Tyr Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Asp Ala Ile Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Lys Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Thr Ala Glu Ser Ile 
            740                 745                 750         


<210>  108
<211>  776
<212>  PRT
<213>  Mus musculus

<400>  108

Met Ser Ile Asn Leu Thr Leu Asp Ile Tyr Ile Tyr Phe Leu Asn Asn 
1               5                   10                  15      


Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe Val 
            20                  25                  30          


Cys Ser Lys Gln Tyr Trp Arg Met Asn His Val Asn Val His Arg Glu 
        35                  40                  45              


Phe His Thr Ser Lys Lys Ser Cys Lys Trp Asn Arg Ser Glu Ala His 
    50                  55                  60                  


Cys Ser Lys His Trp His Ser Pro Ser Asn His Gly Leu His Phe Gly 
65                  70                  75                  80  


Ile Val Arg Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys Val Ser 
                85                  90                  95      


Ile His Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala 
            100                 105                 110         


Ile Phe Gly Ser Gln Asn Glu Met Val Thr Arg Leu Ala Gln Phe Lys 
        115                 120                 125             


Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Lys Gly Trp Leu Lys 
    130                 135                 140                 


Gln Lys Asn Val Lys Gln Ala Val Glu Ser Leu Lys Asn Tyr Ser Asp 
145                 150                 155                 160 


Lys Ser Ala Gly Lys Asn Ser Leu Ala Glu Gln Lys Ser Tyr Phe Ala 
                165                 170                 175     


Asp Lys Glu Glu Asp Ser Gly Lys His Ser Leu Phe His Tyr Thr Tyr 
            180                 185                 190         


Gly Ile Thr Thr Arg Phe Gly Glu Ser Phe Ser Val Leu Ala Asn His 
        195                 200                 205             


Ile Asn Ser Tyr Phe Lys Ser Lys Gly Lys Met Ser Gln Thr Lys Glu 
    210                 215                 220                 


Asp Lys Gln Leu Gln Asp Lys Pro Asp Leu Glu Glu Arg Lys Ser Ser 
225                 230                 235                 240 


Ser Pro Gly Pro Asp Thr Val Ala Asp Arg Pro Asp Ser Glu Ser Pro 
                245                 250                 255     


Leu Glu Val Lys Asp Lys Leu Ser Ser Pro Thr Gln Met Pro Glu Ala 
            260                 265                 270         


His Pro Val Ser Ala Lys Gln Ser Ile Ala Asn Phe Leu Ser Arg Pro 
        275                 280                 285             


Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly Leu Val 
    290                 295                 300                 


Pro Lys Leu Lys Ser Asp Pro Lys Ser Pro Pro Glu Glu Gln Glu Val 
305                 310                 315                 320 


Ser Ala Lys Thr Glu Gln Ala Val Asn Lys Asp Lys Lys Ala Glu Glu 
                325                 330                 335     


Lys Lys Arg Val Leu Leu Gln Gln Glu Lys Ile Ile Ala Arg Val Ser 
            340                 345                 350         


Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg Thr Ala 
        355                 360                 365             


Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe His Leu 
    370                 375                 380                 


Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Ile Lys Glu Lys Ile Ile 
385                 390                 395                 400 


Pro Tyr Leu Leu Arg Leu Arg Gln Val Lys Asp Glu Thr Leu Gln Ala 
                405                 410                 415     


Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro Val Lys 
            420                 425                 430         


Gly Arg Gly Ile Arg Ile Leu Thr Ile Asp Gly Gly Gly Thr Arg Gly 
        435                 440                 445             


Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr Gln Lys 
    450                 455                 460                 


Pro Ile His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr Gly Ala 
465                 470                 475                 480 


Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp Glu Cys 
                485                 490                 495     


Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Thr Gln Asn Val 
            500                 505                 510         


Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr Asp Ser 
        515                 520                 525             


Asn Thr Trp Glu Lys Ile Leu Lys Asp Arg Ile Gly Ser Ala Leu Met 
    530                 535                 540                 


Ile Glu Thr Ala Arg Asn Pro Ala Cys Pro Lys Val Ala Ala Ile Ser 
545                 550                 555                 560 


Thr Ile Val Asn Arg Gly Gln Thr Pro Lys Ala Phe Val Phe Arg Asn 
                565                 570                 575     


Tyr Gly His Phe Pro Gly Thr Asn Ser His Tyr Leu Gly Gly Cys Gln 
            580                 585                 590         


Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro Gly Tyr 
        595                 600                 605             


Phe Ala Glu Tyr Ala Leu Gly Ser Asp Leu His Gln Asp Gly Gly Leu 
    610                 615                 620                 


Leu Leu Asn Asn Pro Ser Ala Leu Ala Leu His Glu Cys Lys Cys Ile 
625                 630                 635                 640 


Trp Pro Asp Thr Pro Leu Glu Cys Ile Val Ser Leu Gly Thr Gly Arg 
                645                 650                 655     


Tyr Glu Ser Asp Val Arg Asn Thr Ser Thr Tyr Thr Ser Leu Lys Thr 
            660                 665                 670         


Lys Leu Ser Asn Val Ile Ser Ser Ala Thr Asp Thr Glu Glu Val His 
        675                 680                 685             


Ile Met Leu Asp Gly Leu Leu Pro Ser Asp Thr Tyr Phe Arg Phe Asn 
    690                 695                 700                 


Pro Val Ile Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asp Glu Lys 
705                 710                 715                 720 


Leu Asp Gln Leu Gln Leu Glu Gly Met Lys Tyr Ile Glu Arg Asn Asp 
                725                 730                 735     


Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys Thr Thr 
            740                 745                 750         


Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Ser Asp Met Tyr Glu 
        755                 760                 765             


Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775     


<210>  109
<211>  224
<212>  PRT
<213>  Mus musculus

<400>  109

Met Pro Gly Gly Leu Leu Leu Gly Asp Glu Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Ile Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Gly Glu Thr Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Lys Gly Arg Asp Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Val Glu Lys Asp Asp Asn Asn Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Ile Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Asp Ser Leu Gln Leu Thr Gly Thr Lys Pro Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Lys Gly Glu Ser Val Met Val Val Pro Thr 
            180                 185                 190         


Leu Ser Glu Glu Glu Ala Lys Gln Cys Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  110
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  111
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Gly Leu His Leu Arg Pro Tyr Arg Val Gly Leu Leu Pro Asp Gly 
1               5                   10                  15      


Leu Leu Phe Leu Leu Leu Leu Leu Met Leu Leu Ala Asp Pro Ala Leu 
            20                  25                  30          


Pro Ala Gly Arg His Pro Pro Val Val Leu Val Pro Gly Asp Leu Gly 
        35                  40                  45              


Asn Gln Leu Glu Ala Lys Leu Asp Lys Pro Thr Val Val His Tyr Leu 
    50                  55                  60                  


Cys Ser Lys Lys Thr Glu Ser Tyr Phe Thr Ile Trp Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Leu Leu Pro Val Ile Ile Asp Cys Trp Ile Asp Asn Ile Arg Leu 
                85                  90                  95      


Val Tyr Asn Lys Thr Ser Arg Ala Thr Gln Phe Pro Asp Gly Val Asp 
            100                 105                 110         


Val Arg Val Pro Gly Phe Gly Lys Thr Phe Ser Leu Glu Phe Leu Asp 
        115                 120                 125             


Pro Ser Lys Ser Ser Val Gly Ser Tyr Phe His Thr Met Val Glu Ser 
    130                 135                 140                 


Leu Val Gly Trp Gly Tyr Thr Arg Gly Glu Asp Val Arg Gly Ala Pro 
145                 150                 155                 160 


Tyr Asp Trp Arg Arg Ala Pro Asn Glu Asn Gly Pro Tyr Phe Leu Ala 
                165                 170                 175     


Leu Arg Glu Met Ile Glu Glu Met Tyr Gln Leu Tyr Gly Gly Pro Val 
            180                 185                 190         


Val Leu Val Ala His Ser Met Gly Asn Met Tyr Thr Leu Tyr Phe Leu 
        195                 200                 205             


Gln Arg Gln Pro Gln Ala Trp Lys Asp Lys Tyr Ile Arg Ala Phe Val 
    210                 215                 220                 


Ser Leu Gly Ala Pro Trp Gly Gly Val Ala Lys Thr Leu Arg Val Leu 
225                 230                 235                 240 


Ala Ser Gly Asp Asn Asn Arg Ile Pro Val Ile Gly Pro Leu Lys Ile 
                245                 250                 255     


Arg Glu Gln Gln Arg Ser Ala Val Ser Thr Ser Trp Leu Leu Pro Tyr 
            260                 265                 270         


Asn Tyr Thr Trp Ser Pro Glu Lys Val Phe Val Gln Thr Pro Thr Ile 
        275                 280                 285             


Asn Tyr Thr Leu Arg Asp Tyr Arg Lys Phe Phe Gln Asp Ile Gly Phe 
    290                 295                 300                 


Glu Asp Gly Trp Leu Met Arg Gln Asp Thr Glu Gly Leu Val Glu Ala 
305                 310                 315                 320 


Thr Met Pro Pro Gly Val Gln Leu His Cys Leu Tyr Gly Thr Gly Val 
                325                 330                 335     


Pro Thr Pro Asp Ser Phe Tyr Tyr Glu Ser Phe Pro Asp Arg Asp Pro 
            340                 345                 350         


Lys Ile Cys Phe Gly Asp Gly Asp Gly Thr Val Asn Leu Lys Ser Ala 
        355                 360                 365             


Leu Gln Cys Gln Ala Trp Gln Ser Arg Gln Glu His Gln Val Leu Leu 
    370                 375                 380                 


Gln Glu Leu Pro Gly Ser Glu His Ile Glu Met Leu Ala Asn Ala Thr 
385                 390                 395                 400 


Thr Leu Ala Tyr Leu Lys Arg Val Leu Leu Gly Pro 
                405                 410         


<210>  112
<211>  168
<212>  PRT
<213>  Mus musculus

<400>  112

Met Lys Lys Phe Phe Ala Ile Ala Val Leu Ala Gly Ser Val Val Thr 
1               5                   10                  15      


Thr Ala His Ser Ser Leu Leu Asn Leu Lys Ser Met Val Glu Ala Ile 
            20                  25                  30          


Thr His Arg Asn Ser Ile Leu Ser Phe Val Gly Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Leu Gly Gly Arg Gly His Pro Met Asp Glu Val Asp Trp Cys Cys 
    50                  55                  60                  


His Ala His Asp Cys Cys Tyr Glu Lys Leu Phe Glu Gln Gly Cys Arg 
65                  70                  75                  80  


Pro Tyr Val Asp His Tyr Asp His Arg Ile Glu Asn Gly Thr Met Ile 
                85                  90                  95      


Val Cys Thr Glu Leu Asn Glu Thr Glu Cys Asp Lys Gln Thr Cys Glu 
            100                 105                 110         


Cys Asp Lys Ser Leu Thr Leu Cys Leu Lys Asp His Pro Tyr Arg Asn 
        115                 120                 125             


Lys Tyr Arg Gly Tyr Phe Asn Val Tyr Cys Gln Gly Pro Thr Pro Asn 
    130                 135                 140                 


Cys Ser Ile Tyr Asp Pro Tyr Pro Glu Glu Val Thr Cys Gly His Gly 
145                 150                 155                 160 


Leu Pro Ala Thr Pro Val Ser Thr 
                165             


<210>  113
<211>  142
<212>  PRT
<213>  Mus musculus

<400>  113

Met Lys Pro Pro Ile Ala Leu Ala Cys Leu Cys Leu Leu Val Pro Leu 
1               5                   10                  15      


Ala Gly Gly Asn Leu Val Gln Phe Gly Val Met Ile Glu Arg Met Thr 
            20                  25                  30          


Gly Lys Pro Ala Leu Gln Tyr Asn Asp Tyr Gly Cys Tyr Cys Gly Val 
        35                  40                  45              


Gly Gly Ser His Trp Pro Val Asp Glu Thr Asp Trp Cys Cys His Ala 
    50                  55                  60                  


His Asp Cys Cys Tyr Gly Arg Leu Glu Lys Leu Gly Cys Asp Pro Lys 
65                  70                  75                  80  


Leu Glu Lys Tyr Leu Phe Ser Ile Thr Arg Asp Asn Ile Phe Cys Ala 
                85                  90                  95      


Gly Arg Thr Ala Cys Gln Arg His Thr Cys Glu Cys Asp Lys Arg Ala 
            100                 105                 110         


Ala Leu Cys Phe Arg His Asn Leu Asn Thr Tyr Asn Arg Lys Tyr Ala 
        115                 120                 125             


His Tyr Pro Asn Lys Leu Cys Thr Gly Pro Thr Pro Pro Cys 
    130                 135                 140         


<210>  114
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Lys Ser Pro His Val Leu Val Phe Leu Cys Leu Leu Val Ala Leu 
1               5                   10                  15      


Val Thr Gly Asn Leu Val Gln Phe Gly Val Met Ile Glu Lys Met Thr 
            20                  25                  30          


Gly Lys Ser Ala Leu Gln Tyr Asn Asp Tyr Gly Cys Tyr Cys Gly Ile 
        35                  40                  45              


Gly Gly Ser His Trp Pro Val Asp Gln Thr Asp Trp Cys Cys His Ala 
    50                  55                  60                  


His Asp Cys Cys Tyr Gly Arg Leu Glu Lys Leu Gly Cys Glu Pro Lys 
65                  70                  75                  80  


Leu Glu Lys Tyr Leu Phe Ser Val Ser Glu Arg Gly Ile Phe Cys Ala 
                85                  90                  95      


Gly Arg Thr Thr Cys Gln Arg Leu Thr Cys Glu Cys Asp Lys Arg Ala 
            100                 105                 110         


Ala Leu Cys Phe Arg Arg Asn Leu Gly Thr Tyr Asn Arg Lys Tyr Ala 
        115                 120                 125             


His Tyr Pro Asn Lys Leu Cys Thr Gly Pro Thr Pro Pro Cys 
    130                 135                 140         


<210>  115
<211>  230
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  115

Met Cys Gly Asn Asn Met Ser Ala Pro Met Pro Ala Val Val Pro Ala 
1               5                   10                  15      


Ala Arg Lys Ala Thr Ala Ala Val Ile Phe Leu His Gly Leu Gly Asp 
            20                  25                  30          


Thr Gly His Gly Trp Ala Glu Ala Phe Ala Gly Ile Lys Ser Pro His 
        35                  40                  45              


Ile Lys Tyr Ile Cys Pro His Ala Pro Val Met Pro Val Thr Leu Asn 
    50                  55                  60                  


Met Asn Met Ala Met Pro Ser Trp Phe Asp Ile Val Gly Leu Ser Pro 
65                  70                  75                  80  


Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Thr Val 
                85                  90                  95      


Lys Ala Leu Ile Asp Gln Glu Val Lys Asn Gly Ile Pro Ser Asn Arg 
            100                 105                 110         


Ile Ile Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr 
        115                 120                 125             


Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys 
    130                 135                 140                 


Trp Leu Pro Leu Arg Ala Ser Phe Ser Gln Gly Pro Ile Asn Ser Ala 
145                 150                 155                 160 


Asn Arg Asp Ile Ser Val Leu Gln Cys His Gly Asp Cys Asp Pro Leu 
                165                 170                 175     


Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Arg Leu Lys Ala Leu 
            180                 185                 190         


Ile Asn Pro Ala Asn Val Thr Phe Lys Ile Tyr Glu Gly Met Met His 
        195                 200                 205             


Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys His Phe Ile Asp Lys 
    210                 215                 220                 


Leu Leu Pro Pro Ile Asp 
225                 230 


<210>  116
<211>  412
<212>  PRT
<213>  Mus musculus

<400>  116

Met Asp Arg His Leu Cys Thr Cys Arg Glu Thr Gln Leu Arg Ser Gly 
1               5                   10                  15      


Leu Leu Leu Pro Leu Phe Leu Leu Met Met Leu Ala Asp Leu Thr Leu 
            20                  25                  30          


Pro Ala Gln Arg His Pro Pro Val Val Leu Val Pro Gly Asp Leu Gly 
        35                  40                  45              


Asn Gln Leu Glu Ala Lys Leu Asp Lys Pro Lys Val Val His Tyr Leu 
    50                  55                  60                  


Cys Ser Lys Lys Thr Asp Ser Tyr Phe Thr Leu Trp Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Leu Leu Pro Val Ile Ile Asp Cys Trp Ile Asp Asn Ile Arg Leu 
                85                  90                  95      


Val Tyr Asn Arg Thr Ser Arg Ala Thr Gln Phe Pro Asp Gly Val Asp 
            100                 105                 110         


Val Arg Val Pro Gly Phe Gly Glu Thr Phe Ser Met Glu Phe Leu Asp 
        115                 120                 125             


Pro Ser Lys Arg Asn Val Gly Ser Tyr Phe Tyr Thr Met Val Glu Ser 
    130                 135                 140                 


Leu Val Gly Trp Gly Tyr Thr Arg Gly Glu Asp Val Arg Gly Ala Pro 
145                 150                 155                 160 


Tyr Asp Trp Arg Arg Ala Pro Asn Glu Asn Gly Pro Tyr Phe Leu Ala 
                165                 170                 175     


Leu Arg Glu Met Ile Glu Glu Met Tyr Gln Met Tyr Gly Gly Pro Val 
            180                 185                 190         


Val Leu Val Ala His Ser Met Gly Asn Val Tyr Met Leu Tyr Phe Leu 
        195                 200                 205             


Gln Arg Gln Pro Gln Val Trp Lys Asp Lys Tyr Ile His Ala Phe Val 
    210                 215                 220                 


Ser Leu Gly Ala Pro Trp Gly Gly Val Ala Lys Thr Leu Arg Val Leu 
225                 230                 235                 240 


Ala Ser Gly Asp Asn Asn Arg Ile Pro Val Ile Gly Pro Leu Lys Ile 
                245                 250                 255     


Arg Glu Gln Gln Arg Ser Ala Val Ser Thr Ser Trp Leu Leu Pro Tyr 
            260                 265                 270         


Asn His Thr Trp Ser His Glu Lys Val Phe Val Tyr Thr Pro Thr Thr 
        275                 280                 285             


Asn Tyr Thr Leu Arg Asp Tyr His Arg Phe Phe Arg Asp Ile Gly Phe 
    290                 295                 300                 


Glu Asp Gly Trp Phe Met Arg Gln Asp Thr Glu Gly Leu Val Glu Ala 
305                 310                 315                 320 


Met Thr Pro Pro Gly Val Glu Leu His Cys Leu Tyr Gly Thr Gly Val 
                325                 330                 335     


Pro Thr Pro Asn Ser Phe Tyr Tyr Glu Ser Phe Pro Asp Arg Asp Pro 
            340                 345                 350         


Lys Ile Cys Phe Gly Asp Gly Asp Gly Thr Val Asn Leu Glu Ser Val 
        355                 360                 365             


Leu Gln Cys Gln Ala Trp Gln Ser Arg Gln Glu His Arg Val Ser Leu 
    370                 375                 380                 


Gln Glu Leu Pro Gly Ser Glu His Ile Glu Met Leu Ala Asn Ala Thr 
385                 390                 395                 400 


Thr Leu Ala Tyr Leu Lys Arg Val Leu Leu Glu Pro 
                405                 410         


<210>  117
<211>  1458
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  117

Met Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro Arg Arg 
1               5                   10                  15      


Cys Thr Glu Gly Ala Ala Ala Ala Leu Ser Pro Glu Arg Val Leu Lys 
            20                  25                  30          


Trp Gln Glu Lys Gly Ile Phe Ile Ile Gln Ser Glu Ser Leu Lys Ser 
        35                  40                  45              


Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Ser Cys Lys Gln 
    50                  55                  60                  


Pro Asn Lys Asn Met Leu Trp Lys Trp Val Ser Asn Gln His Leu Phe 
65                  70                  75                  80  


Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Leu Ser Asn Pro Glu 
                85                  90                  95      


Gln Pro Leu Gly Leu Tyr Glu Cys Asp Ser Thr His Val Ser Leu Arg 
            100                 105                 110         


Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln His Thr Val 
        115                 120                 125             


Gln Val Lys Gln Asp Asn Ile Ile Val Ala Ser Gly Lys Arg Leu His 
    130                 135                 140                 


Lys Trp Ile Ser Tyr Met Ser Asp Ser Gly Asp Ile Cys Gln His Val 
145                 150                 155                 160 


His Lys Asp Leu Tyr Thr Arg Lys Gly Asn Ala His Gly Thr Pro Cys 
                165                 170                 175     


Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg 
            180                 185                 190         


Glu Gly Arg Gln Asp Asp Ser Leu Trp Cys Ala Thr Thr Ser Arg Tyr 
        195                 200                 205             


Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu 
    210                 215                 220                 


Val Gly Cys Asp Ala Val Trp Glu Lys Asp Leu Asn Ser His Ile Cys 
225                 230                 235                 240 


Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser 
                245                 250                 255     


Ser Cys Gln Met His Gly Gly Ala Leu Leu Ser Ile Val Asp Glu Ala 
            260                 265                 270         


Glu Glu Asn Phe Ile Arg Lys Gln Val Ser Gly Glu Ala Val Glu Val 
        275                 280                 285             


Trp Thr Gly Leu Asn Gln Leu Asp Val Asn Ala Gly Trp Gln Trp Ser 
    290                 295                 300                 


Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser Pro Glu Ile Ser Phe 
305                 310                 315                 320 


Glu Pro Phe Val Glu Tyr His Cys Gly Thr Phe Asn Ser Phe Met Pro 
                325                 330                 335     


Arg Ala Trp Arg Ser Arg Asn Cys Glu Ser Thr Leu Pro Tyr Ile Cys 
            340                 345                 350         


Lys Lys Tyr Leu Asn His Val Asp Asp Glu Ile Val Glu Lys Asp Ala 
        355                 360                 365             


Trp Lys Tyr Tyr Ala Thr Asp Cys Glu Pro Gly Trp Ala Pro Tyr His 
    370                 375                 380                 


Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp Asn Glu Ala 
385                 390                 395                 400 


Leu His Ser Cys Leu Ser Ser Asn Ser Thr Leu Ile Asp Ile Gly Ser 
                405                 410                 415     


Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asn Glu Asn Ala 
            420                 425                 430         


Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Thr Phe Pro Val Ser Phe 
        435                 440                 445             


Glu Trp Ser Asn Gly Ser Ser Val Ile Phe Thr Asn Trp His Thr Leu 
    450                 455                 460                 


Glu Pro Gln Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser Ala Glu 
465                 470                 475                 480 


Gln Ser Glu Gly His Trp Lys Val Thr Asp Cys Glu Glu Thr His Phe 
                485                 490                 495     


Tyr Val Cys Lys Lys Pro Gly His Val Leu Ser Asp Ala Glu Ser Gly 
            500                 505                 510         


Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys Ile Asp 
        515                 520                 525             


Thr Val Leu Arg Ser Phe Asp His Ala Ser Ser Gly Tyr Tyr Cys Pro 
    530                 535                 540                 


Pro Ala Leu Val Thr Ile Ala Asp Arg Phe Glu Gln Ala Phe Ile Thr 
545                 550                 555                 560 


Ser Leu Ile Ser Ser Val Val Asn Met Lys Asp Ser Tyr Phe Trp Ile 
                565                 570                 575     


Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys Thr Ala 
            580                 585                 590         


Gly Gln Lys Ser Glu Pro Val Gln Tyr Thr His Trp Asn Ala His Gln 
        595                 600                 605             


Pro Arg Ser Ser Gly Gly Cys Val Ala Ile Arg Gly Arg Asn Pro Ile 
    610                 615                 620                 


Gly Arg Trp Glu Val Lys Asp Cys Val His Phe Lys Ala Met Ser Leu 
625                 630                 635                 640 


Cys Lys Gln Pro Val Glu Thr Arg Glu Lys Met Glu His Glu Glu Arg 
                645                 650                 655     


Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Gln Pro Gly Leu 
            660                 665                 670         


Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met Lys Arg 
        675                 680                 685             


Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala His Leu 
    690                 695                 700                 


Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu Leu Leu 
705                 710                 715                 720 


His Pro Lys Phe Asn Arg Ser Glu Glu Arg Gln Phe Trp Ile Gly Phe 
                725                 730                 735     


Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser Asp Gly 
            740                 745                 750         


Thr Pro Val Ile Ser Ser Phe Leu Asp Asn Asn Tyr Phe Gly Glu Asp 
        755                 760                 765             


Thr Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu Pro Leu 
    770                 775                 780                 


His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg Asp Val 
785                 790                 795                 800 


Arg Pro Lys Ile Pro Ser Trp Tyr Gln Tyr Asp Ala Pro Trp Leu Phe 
                805                 810                 815     


His Gln Asp Ala Glu Tyr Leu Phe Tyr Pro His Ser Ser Glu Trp Ser 
            820                 825                 830         


Ser Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Ile Leu Thr Ile 
        835                 840                 845             


His Ser Ala His Glu Gln Glu Phe Ile Leu Ser Lys Ile Lys Ala Leu 
    850                 855                 860                 


Ser Lys Tyr Gly Ala Asn Trp Trp Ile Gly Leu Gln Glu Glu Thr Ala 
865                 870                 875                 880 


Asn Asp Glu Leu Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr Gln Asn 
                885                 890                 895     


Trp Asp Lys Glu Arg Asp Arg Ser Met Asn Asn Gln Ser Gln Arg Cys 
            900                 905                 910         


Ala Phe Ile Ser Ser Ile Thr Gly Leu Trp Asp Arg Glu Glu Cys Ser 
        915                 920                 925             


Val Ser Met Pro Ser Ile Cys Lys Arg Lys Thr Phe Trp Val Ile Glu 
    930                 935                 940                 


Lys Glu Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys Gly Trp 
945                 950                 955                 960 


Leu Tyr Phe Asp Tyr Lys Cys Leu Leu Val Asn Val Pro Lys Asp Pro 
                965                 970                 975     


Ser Asn Trp Lys Asn Trp Thr Gln Ala Arg Asp Phe Cys Phe Asp Glu 
            980                 985                 990         


Gly Gly Thr Leu Val Ala Ile Glu  Ser Glu Val Glu Gln  Ala Phe Ile 
        995                 1000                 1005             


Thr Met  Asn Leu Phe Gly Gln  Thr Thr Asn Val Trp  Ile Gly Leu 
    1010                 1015                 1020             


Gln Asn  Asp Asp Tyr Glu Lys  Trp Leu Asn Gly Asn  Pro Val Ala 
    1025                 1030                 1035             


Tyr Ser  Asn Trp Ser Pro Ser  Asp Ile Ile Asn Ile  Pro Ser Tyr 
    1040                 1045                 1050             


Asn Thr  Thr Ala Asp Gln Lys  Pro Ile Pro Leu Cys  Ala Leu Leu 
    1055                 1060                 1065             


Ser Ser  Asn Pro Asn Phe His  Phe Thr Gly Lys Trp  Tyr Phe Glu 
    1070                 1075                 1080             


Asp Cys  Gly Lys Glu Gly Tyr  Gly Phe Val Cys Glu  Lys Ile Gln 
    1085                 1090                 1095             


Asp Ser  Ala Gly His Glu Val  Asn Thr Ser Ile Met  Asp Pro Ile 
    1100                 1105                 1110             


Pro Asn  Thr Leu Glu Tyr Gly  Asn Arg Thr Tyr Lys  Ile Ile Asn 
    1115                 1120                 1125             


Ala Asn  Met Thr Trp Tyr Ala  Ala Ile Lys Ser Cys  Gln Leu His 
    1130                 1135                 1140             


Gly Ala  Glu Leu Val Ser Ile  Thr Asp Gln Tyr His  Gln Ser Phe 
    1145                 1150                 1155             


Leu Thr  Val Ile Leu Ser Arg  Leu Gly His Ala His  Trp Ile Gly 
    1160                 1165                 1170             


Leu Phe  Thr Ala Asp Asn Gly  Leu His Phe Asp Trp  Ser Asp Gly 
    1175                 1180                 1185             


Thr Lys  Ser Ser Phe Thr Phe  Trp Lys Asp Glu Asp  Ser Ser Phe 
    1190                 1195                 1200             


Leu Gly  Asp Cys Val Phe Ala  Asp Thr Ser Gly Arg  Trp His Ser 
    1205                 1210                 1215             


Thr Ala  Cys Glu Ser Phe Leu  Gln Gly Ala Ile Cys  His Val Pro 
    1220                 1225                 1230             


Thr Glu  Thr Arg Pro Phe Glu  His Pro Glu Leu Cys  Ser Glu Thr 
    1235                 1240                 1245             


Ser Ile  Pro Trp Ile Lys Phe  Lys Ser Asn Cys Tyr  Ser Phe Ser 
    1250                 1255                 1260             


Thr Val  Leu His Ser Ala Ser  Phe Glu Ala Ala His  Glu Phe Cys 
    1265                 1270                 1275             


Lys Lys  Glu Gly Ser Asn Leu  Leu Thr Ile Lys Asp  Glu Ala Glu 
    1280                 1285                 1290             


Asn Ser  Phe Leu Leu Glu Glu  Pro Phe Ala Phe Gly  Ala Ser Val 
    1295                 1300                 1305             


Gln Met  Val Trp Leu Asn Ala  Gln Phe Asp Asn Glu  Thr Val Lys 
    1310                 1315                 1320             


Trp Leu  Asp Gly Thr Pro Ala  Asp Gln Ser Asn Trp  Gly Ile Arg 
    1325                 1330                 1335             


Lys Pro  Asp Met Ala His Phe  Glu Pro His Gln Cys  Leu Ala Leu 
    1340                 1345                 1350             


Arg Ile  Pro Glu Gly Val Trp  Gln Leu Ser Pro Cys  Gln Lys Asn 
    1355                 1360                 1365             


Met Gly  Phe Ile Cys Lys Met  Lys Ala Asp Ile His  Thr Val Lys 
    1370                 1375                 1380             


Glu His  Pro Gly Lys Gly Pro  Ser His Ser Ile Val  Pro Leu Ala 
    1385                 1390                 1395             


Val Ala  Leu Thr Leu Val Val  Ile Leu Ala Ile Ile  Thr Leu Ser 
    1400                 1405                 1410             


Phe Tyr  Ile Tyr Lys Gln Asn  Lys Gly Phe Phe Arg  Arg Leu Ala 
    1415                 1420                 1425             


Gly Val  Gly Asn Ser Tyr Tyr  Pro Thr Thr Asn Phe  Ser Thr Ile 
    1430                 1435                 1440             


His Leu  Glu Glu Asn Ile Leu  Ile Ser Asp Leu Glu  Lys Asn Asp 
    1445                 1450                 1455             


<210>  118
<211>  666
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<400>  118

Met Pro Pro Ser Cys Arg Pro Ser Thr Arg Ala Pro Ser Arg Ser Cys 
1               5                   10                  15      


Thr Leu Arg Ser Cys Ser Thr Cys Pro Thr Ser Ser Ala Thr Thr Pro 
            20                  25                  30          


Ala Gly Arg Trp Arg Thr Trp Pro Trp Arg Leu Gly Ile Arg Glu Cys 
        35                  40                  45              


Phe His His Ser Arg Ile Ile Ser Cys Ala Asn Ser Thr Glu Asn Glu 
    50                  55                  60                  


Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys Gly Asp Gly Glu 
65                  70                  75                  80  


Ile Leu Leu Glu Leu Val Gln Tyr Cys His Ala Gln Met Asp Val Thr 
                85                  90                  95      


Asp Asn Lys Gly Glu Thr Ala Phe His Tyr Ala Val Gln Gly Asp Asn 
            100                 105                 110         


Ser Gln Val Leu Gln Leu Leu Gly Lys Asn Ala Ser Thr Gly Val Asn 
        115                 120                 125             


Gln Val Asn Ser Gln Gly Leu Thr Pro Leu His Leu Ala Cys Gln Met 
    130                 135                 140                 


Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys Asn Ala Arg Cys 
145                 150                 155                 160 


Asn Ile Leu Gly Pro Glu Gly Tyr Pro Ile His Thr Ala Met Lys Phe 
                165                 170                 175     


Ser Gln Arg Gly Cys Ala Glu Met Ile Ile Ser Met Asp Ser Asn Gln 
            180                 185                 190         


Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu His Trp Ala 
        195                 200                 205             


Lys Asn Ala Glu Met Ala Arg Leu Leu Leu Lys Arg Gly Cys Asp Val 
    210                 215                 220                 


Asn Ser Thr Ser Ser Ser Gly Tyr Thr Ala Leu His Val Ala Val Met 
225                 230                 235                 240 


Arg Asn Arg Phe Glu Cys Val Met Val Leu Leu Thr Tyr Gly Ala Asn 
                245                 250                 255     


Ala Asp Ala Arg Gly Glu His Gly Asn Thr Pro Leu His Leu Ala Val 
            260                 265                 270         


Ser Lys Asp Asn Val Xaa Met Val Lys Ala Leu Ile Val Phe Gly Ala 
        275                 280                 285             


Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro Ala Phe Ile Ala 
    290                 295                 300                 


Ser Lys Ile Ser Lys Gln Leu Gln Asp Val Met His Ile Ser Arg Ala 
305                 310                 315                 320 


Arg Lys Pro Ala Phe Ile Leu Ser Ser Leu Arg Asp Glu Lys Arg Thr 
                325                 330                 335     


His Asp His Leu Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val 
            340                 345                 350         


Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr 
        355                 360                 365             


Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu 
    370                 375                 380                 


Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Val 
385                 390                 395                 400 


Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu 
                405                 410                 415     


Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr 
            420                 425                 430         


Lys Met Thr Asp Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu 
        435                 440                 445             


Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala 
    450                 455                 460                 


Pro Glu Ser Val Arg Glu Pro Arg Phe Ser Pro Asn Ile Asn Leu Lys 
465                 470                 475                 480 


Pro Leu Thr Gln Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser 
                485                 490                 495     


Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp 
            500                 505                 510         


Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile 
        515                 520                 525             


His Glu Tyr Asn Gln Asp Leu Ile Arg Lys Gly Gln Ser Glu Arg Val 
    530                 535                 540                 


Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln 
545                 550                 555                 560 


Val Pro Val Thr Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu 
                565                 570                 575     


Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val 
            580                 585                 590         


Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala 
        595                 600                 605             


Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu 
    610                 615                 620                 


Gly Ala Asp Ile Met Leu Asp Glu Val Ser Asp Ala Val Leu Val Asn 
625                 630                 635                 640 


Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Gln Phe 
                645                 650                 655     


Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            660                 665     


<210>  119
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


His Leu Leu Leu Ser Pro 
                805     


<210>  120
<211>  346
<212>  PRT
<213>  Bos taurus

<400>  120

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Ile Lys Thr Val Lys Gly Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Glu Ala Leu His Lys Ala Ile Thr Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Glu Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Lys Gly Lys Pro Leu Asp Glu Val Leu 
                85                  90                  95      


Lys Lys Ala Leu Leu Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Glu Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Asn Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Arg Glu Ile Arg Glu Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Ala Ser Asp Thr Ser Gly Asp Tyr 
                165                 170                 175     


Glu Lys Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Glu Leu 
            180                 185                 190         


Ala Val Asn Asp Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Ile Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro His Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Ser Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Val Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Gln Pro Met Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Ile Gly Thr Arg His Lys Thr Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Cys Tyr Gln Lys Leu Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Arg Asp 
            340                 345     


<210>  121
<211>  346
<212>  PRT
<213>  Sus scrofa

<400>  121

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Asp Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Ile Lys Thr Val Lys Gly Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Glu Ala Ser His Lys Ala Ile Thr Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Glu Ile His Thr Lys Arg Thr Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Lys Gly Lys Pro Leu Asp Glu Ala Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Ala Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Asn Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Arg Glu Ile Arg Glu Ile Asn Arg Val Tyr Lys Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Tyr 
                165                 170                 175     


Gln Lys Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Leu 
            180                 185                 190         


Ala Ile Asn Asp Asp Leu Ala Asp Thr Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Leu Asn Val Phe Ile Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Leu His Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Ser Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Asn Cys Leu Thr Val Val Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Met Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Asn Gly Thr Arg His Lys Thr Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Cys Tyr Gln Lys Leu Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asp 
            340                 345     


<210>  122
<211>  346
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  122

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Asp Asn 
1               5                   10                  15      


Glu Glu Gln Asp Tyr Ile Asn Thr Val Lys Thr Tyr Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Ala Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Gln Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Lys Gly Lys Pro Leu Asp Glu Val Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Asn Asn Lys Glu Ile Arg Glu Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Ala Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Gln Lys Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Thr Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Ala Asp Val Asn Val Phe Thr Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Leu His Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Ser Lys Tyr Ser Gln His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Gln Cys Ala Thr 
            260                 265                 270         


Cys Lys Pro Ala Tyr Phe Ala Glu Lys Leu Tyr Gln Ala Met Lys Gly 
        275                 280                 285             


Ala Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Val Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Lys Tyr Gly 
305                 310                 315                 320 


Val Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  123
<211>  346
<212>  PRT
<213>  Rattus norvegicus

<400>  123

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Cys Tyr Ile Glu Lys 
1               5                   10                  15      


Gln Glu Gln Glu Tyr Val Gln Ala Val Lys Ser Tyr Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Ser Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Thr Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Met Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Thr Thr Arg 
    130                 135                 140                 


Ser Asn Gln Gln Ile Arg Glu Ile Thr Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ala Leu Ala Lys Gly Asp Arg Cys Glu Asp Met 
            180                 185                 190         


Ser Val Asn Gln Asp Leu Ala Asp Thr Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro His Leu Arg Lys Val Phe Gln Asn Tyr 
225                 230                 235                 240 


Arg Lys Tyr Ser Gln His Asp Met Asn Lys Ala Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Thr Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Thr Pro Ala Phe Phe Ala Glu Lys Leu Tyr Glu Ala Met Lys Gly 
        275                 280                 285             


Ala Gly Thr Arg His Lys Thr Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Glu Ile Lys Val Phe Tyr Gln Lys Lys Tyr Gly 
305                 310                 315                 320 


Ile Pro Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  124
<211>  346
<212>  PRT
<213>  Cavia cutleri

<400>  124

Met Ser Met Val Ser Glu Phe Leu Lys Gln Ala Tyr Phe Ile Asp Asn 
1               5                   10                  15      


Gln Glu Gln Asp Tyr Val Lys Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Ser Phe Asp Ala Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Thr Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Lys Gly Lys Pro Leu Asp Glu Ala Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Leu Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Val Ser Arg 
    130                 135                 140                 


Lys Asn Arg Glu Ile Lys Glu Ile Asn Arg Val Tyr Arg Asp Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Gln Lys Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Cys Glu Asp Leu 
            180                 185                 190         


Ser Val Asn Asp Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Ile Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Ser His Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Gln His Asp Met Asn Lys Ala Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Asn Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Thr Pro Ala Phe Phe Ala Glu Lys Leu His Leu Ala Met Lys Gly 
        275                 280                 285             


Ala Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Val Tyr Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Gln 
            340                 345     


<210>  125
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val 
        195                 200                 205             


Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn 
    210                 215                 220                 


Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys 
            260                 265                 270         


Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met 
        275                 280                 285             


Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe 
305                 310                 315                 320 


Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn 
        355                 360                 365             


Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210>  126
<211>  440
<212>  PRT
<213>  Mus musculus

<400>  126

Met Val Pro Leu Lys Leu Gln Ala Leu Phe Cys Leu Leu Cys Cys Leu 
1               5                   10                  15      


Pro Trp Val His Pro Phe His Trp Gln Asp Thr Ser Ser Phe Asp Phe 
            20                  25                  30          


Arg Pro Ser Val Met Phe His Lys Leu Gln Ser Val Met Ser Ala Ala 
        35                  40                  45              


Gly Ser Gly His Ser Lys Ile Pro Lys Gly Asn Gly Ser Tyr Pro Val 
    50                  55                  60                  


Gly Cys Thr Asp Leu Met Phe Gly Tyr Gly Asn Glu Ser Val Phe Val 
65                  70                  75                  80  


Arg Leu Tyr Tyr Pro Ala Gln Asp Gln Gly Arg Leu Asp Thr Val Trp 
                85                  90                  95      


Ile Pro Asn Lys Glu Tyr Phe Leu Gly Leu Ser Ile Phe Leu Gly Thr 
            100                 105                 110         


Pro Ser Ile Val Gly Asn Ile Leu His Leu Leu Tyr Gly Ser Leu Thr 
        115                 120                 125             


Thr Pro Ala Ser Trp Asn Ser Pro Leu Arg Thr Gly Glu Lys Tyr Pro 
    130                 135                 140                 


Leu Ile Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Ile Tyr Ser 
145                 150                 155                 160 


Ala Ile Gly Ile Gly Leu Ala Ser Asn Gly Phe Ile Val Ala Thr Val 
                165                 170                 175     


Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Phe Phe Glu Asp Gln 
            180                 185                 190         


Val Ala Ala Lys Val Glu Asn Arg Ser Trp Leu Tyr Leu Arg Lys Val 
        195                 200                 205             


Lys Gln Glu Glu Ser Glu Ser Val Arg Lys Glu Gln Val Gln Gln Arg 
    210                 215                 220                 


Ala Ile Glu Cys Ser Arg Ala Leu Ser Ala Ile Leu Asp Ile Glu His 
225                 230                 235                 240 


Gly Asp Pro Lys Glu Asn Val Leu Gly Ser Ala Phe Asp Met Lys Gln 
                245                 250                 255     


Leu Lys Asp Ala Ile Asp Glu Thr Lys Ile Ala Leu Met Gly His Ser 
            260                 265                 270         


Phe Gly Gly Ala Thr Val Leu Gln Ala Leu Ser Glu Asp Gln Arg Phe 
        275                 280                 285             


Arg Cys Gly Val Ala Leu Asp Pro Trp Met Tyr Pro Val Asn Glu Glu 
    290                 295                 300                 


Leu Tyr Ser Arg Thr Leu Gln Pro Leu Leu Phe Ile Asn Ser Ala Lys 
305                 310                 315                 320 


Phe Gln Thr Pro Lys Asp Ile Ala Lys Met Lys Lys Phe Tyr Gln Pro 
                325                 330                 335     


Asp Lys Glu Arg Lys Asn Asp Tyr Asn Gln Gly Leu Arg His Gln Asn 
            340                 345                 350         


Phe Asp Asp Phe Thr Phe Val Thr Gly Lys Ile Ile Gly Asn Lys Leu 
        355                 360                 365             


Thr Leu Lys Gly Glu Ile Asp Ser Arg Val Ala Ile Asp Leu Thr Asn 
    370                 375                 380                 


Lys Ala Ser Met Ala Phe Leu Gln Lys His Leu Gly Leu Gln Lys Asp 
385                 390                 395                 400 


Phe Asp Gln Trp Asp Pro Leu Val Glu Gly Asp Asp Glu Asn Leu Ile 
                405                 410                 415     


Pro Gly Ser Pro Phe Asp Ala Val Thr Gln Ala Pro Ala Gln Gln His 
            420                 425                 430         


Ser Pro Gly Ser Gln Thr Gln Asn 
        435                 440 


<210>  127
<211>  444
<212>  PRT
<213>  Canis familiaris

<400>  127

Met Leu Pro Pro Lys Leu His Ala Leu Phe Cys Leu Cys Ser Cys Leu 
1               5                   10                  15      


Thr Leu Val His Pro Ile Asp Trp Gln Asp Leu Asn Pro Val Ala His 
            20                  25                  30          


Ile Arg Ser Ser Ala Trp Ala Asn Lys Ile Gln Ala Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Ile Arg Gln Ser Arg Ile Pro Lys Gly Asn Gly Ser Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp Tyr Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Glu Asp Asp His Ser Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Phe Gly Leu Ser Lys Tyr Leu Gly 
            100                 105                 110         


Thr Pro Trp Leu Met Gly Lys Ile Leu Ser Phe Phe Phe Gly Ser Val 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Thr Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Ile Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Ile Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Ile Glu His Arg Asp Gly Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asn Lys Ser Trp Ser Tyr Leu Gln Glu 
        195                 200                 205             


Leu Lys Pro Gly Asp Glu Glu Ile His Val Arg Asn Glu Gln Val Gln 
    210                 215                 220                 


Lys Arg Ala Lys Glu Cys Ser Gln Ala Leu Asn Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Asp His Gly Arg Pro Ile Lys Asn Val Leu Asp Leu Glu Phe Asp Val 
                245                 250                 255     


Glu Gln Leu Lys Asp Ser Ile Asp Arg Asp Lys Ile Ala Val Ile Gly 
            260                 265                 270         


His Ser Phe Gly Gly Ala Thr Val Leu Gln Ala Leu Ser Glu Asp Gln 
        275                 280                 285             


Arg Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Leu Pro Leu Asp 
    290                 295                 300                 


Asp Ala Ile Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser 
305                 310                 315                 320 


Glu Arg Phe Gln Phe Pro Glu Asn Ile Lys Lys Met Lys Lys Cys Tyr 
                325                 330                 335     


Ser Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His 
            340                 345                 350         


Gln Asn Phe Ala Asp Phe Thr Phe Thr Thr Gly Lys Ile Val Gly Tyr 
        355                 360                 365             


Ile Phe Thr Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu 
    370                 375                 380                 


Cys Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu Arg 
385                 390                 395                 400 


Lys Asp Phe Asp Gln Trp Asp Ser Leu Ile Glu Gly Lys Asp Glu Asn 
                405                 410                 415     


Leu Met Pro Gly Thr Asn Ile Asn Ile Thr Asn Glu His Asp Thr Leu 
            420                 425                 430         


Gln Asn Ser Pro Glu Ala Glu Lys Ser Asn Leu Asp 
        435                 440                 


<210>  128
<211>  444
<212>  PRT
<213>  Bos taurus

<400>  128

Met Leu Pro Ser Lys Leu His Ala Leu Phe Cys Leu Cys Thr Cys Leu 
1               5                   10                  15      


Ala Leu Val Tyr Pro Phe Asp Trp Gln Asp Leu Asn Pro Val Ala Tyr 
            20                  25                  30          


Ile Glu Ser Pro Ala Trp Val Ser Lys Ile Gln Ala Leu Met Ala Ala 
        35                  40                  45              


Ala Asn Ile Gly Gln Ser Lys Ile Pro Arg Gly Asn Gly Ser Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp Tyr Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asp Asp His Ser Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Leu Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Val Gly Lys Ile Met Gly Leu Phe Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Ala Trp Asn Ala His Leu Arg Thr Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala Phe Arg Thr Ile Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Gly Ser Ala Ser Ser Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Val Glu Ile Gly Asn Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Arg Gly Glu Glu Glu Phe Pro Leu Arg Asn Glu Gln Leu Arg 
    210                 215                 220                 


Gln Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Asp His Gly Arg Pro Val Thr Asn Val Leu Asp Leu Glu Phe Asp Val 
                245                 250                 255     


Glu Gln Leu Lys Asp Ser Ile Asp Arg Asp Lys Ile Ala Ile Ile Gly 
            260                 265                 270         


His Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln 
        275                 280                 285             


Arg Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Val Gly 
    290                 295                 300                 


Asp Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser 
305                 310                 315                 320 


Glu Arg Phe Gln Tyr Pro Ser Asn Ile Ile Arg Met Lys Lys Cys Phe 
                325                 330                 335     


Leu Pro Asp Arg Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His 
            340                 345                 350         


Gln Asn Phe Val Asp Phe Thr Phe Ala Thr Ser Lys Ile Ile Gly Tyr 
        355                 360                 365             


Leu Phe Thr Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Ser Leu 
    370                 375                 380                 


Ser Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu Gln 
385                 390                 395                 400 


Lys Asp Phe Asp Gln Trp Asp Ser Leu Val Glu Gly Glu Asp His Asn 
                405                 410                 415     


Leu Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn His Gln Ala Ile Leu 
            420                 425                 430         


Gln Asn Ser Thr Gly Ile Glu Arg Pro Asn Leu Asp 
        435                 440                 


<210>  129
<211>  776
<212>  PRT
<213>  Mus musculus

<400>  129

Met Ser Ile Asn Leu Thr Leu Asp Ile Tyr Ile Tyr Phe Leu Asn Asn 
1               5                   10                  15      


Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe Val 
            20                  25                  30          


Cys Ser Lys Gln Tyr Trp Arg Met Asn His Val Asn Val His Arg Glu 
        35                  40                  45              


Phe His Thr Ser Lys Lys Ser Cys Lys Trp Asn Arg Ser Glu Ala His 
    50                  55                  60                  


Cys Ser Lys His Trp His Ser Pro Ser Asn His Gly Leu His Phe Gly 
65                  70                  75                  80  


Ile Val Arg Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys Val Ser 
                85                  90                  95      


Ile His Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala 
            100                 105                 110         


Ile Phe Gly Ser Gln Asn Glu Met Val Thr Arg Leu Ala Gln Phe Lys 
        115                 120                 125             


Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Lys Gly Trp Leu Lys 
    130                 135                 140                 


Gln Lys Asn Val Lys Gln Ala Val Glu Ser Leu Lys Asn Tyr Ser Asp 
145                 150                 155                 160 


Lys Ser Ala Gly Lys Asn Ser Leu Ala Glu Gln Lys Ser Tyr Phe Ala 
                165                 170                 175     


Asp Lys Glu Glu Asp Ser Gly Lys His Ser Leu Phe His Tyr Thr Tyr 
            180                 185                 190         


Gly Ile Thr Thr Arg Phe Gly Glu Ser Phe Ser Val Leu Ala Asn His 
        195                 200                 205             


Ile Asn Ser Tyr Phe Lys Ser Lys Gly Lys Met Ser Gln Thr Lys Glu 
    210                 215                 220                 


Asp Lys Gln Leu Gln Asp Lys Pro Asp Leu Glu Glu Arg Lys Ser Ser 
225                 230                 235                 240 


Ser Pro Gly Pro Asp Thr Val Ala Asp Arg Pro Asp Ser Glu Ser Pro 
                245                 250                 255     


Leu Glu Val Lys Asp Lys Leu Ser Ser Pro Thr Gln Met Pro Glu Ala 
            260                 265                 270         


His Pro Val Ser Ala Lys Gln Ser Ile Ala Asn Phe Leu Ser Arg Pro 
        275                 280                 285             


Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly Leu Val 
    290                 295                 300                 


Pro Lys Leu Lys Ser Asp Pro Lys Ser Pro Pro Glu Glu Gln Glu Val 
305                 310                 315                 320 


Ser Ala Lys Thr Glu Gln Ala Val Asn Lys Asp Lys Lys Ala Glu Glu 
                325                 330                 335     


Lys Lys Arg Val Leu Leu Gln Gln Glu Lys Ile Ile Ala Arg Val Ser 
            340                 345                 350         


Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg Thr Ala 
        355                 360                 365             


Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe His Leu 
    370                 375                 380                 


Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Ile Lys Glu Lys Ile Ile 
385                 390                 395                 400 


Pro Tyr Leu Leu Arg Leu Arg Gln Val Lys Asp Glu Thr Leu Gln Ala 
                405                 410                 415     


Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro Val Lys 
            420                 425                 430         


Gly Arg Gly Ile Arg Ile Leu Thr Ile Asp Gly Gly Gly Thr Arg Gly 
        435                 440                 445             


Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr Gln Lys 
    450                 455                 460                 


Pro Ile His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr Gly Ala 
465                 470                 475                 480 


Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp Glu Cys 
                485                 490                 495     


Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Thr Gln Asn Val 
            500                 505                 510         


Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr Asp Ser 
        515                 520                 525             


Asn Thr Trp Glu Lys Ile Leu Lys Asp Arg Ile Gly Ser Ala Leu Met 
    530                 535                 540                 


Ile Glu Thr Ala Arg Asn Pro Ala Cys Pro Lys Val Ala Ala Ile Ser 
545                 550                 555                 560 


Thr Ile Val Asn Arg Gly Gln Thr Pro Lys Ala Phe Val Phe Arg Asn 
                565                 570                 575     


Tyr Gly His Phe Pro Gly Thr Asn Ser His Tyr Leu Gly Gly Cys Gln 
            580                 585                 590         


Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro Gly Tyr 
        595                 600                 605             


Phe Ala Glu Tyr Ala Leu Gly Ser Asp Leu His Gln Asp Gly Gly Leu 
    610                 615                 620                 


Leu Leu Asn Asn Pro Ser Ala Leu Ala Leu His Glu Cys Lys Cys Ile 
625                 630                 635                 640 


Trp Pro Asp Thr Pro Leu Glu Cys Ile Val Ser Leu Gly Thr Gly Arg 
                645                 650                 655     


Tyr Glu Ser Asp Val Arg Asn Thr Ser Thr Tyr Thr Ser Leu Lys Thr 
            660                 665                 670         


Lys Leu Ser Asn Val Ile Ser Ser Ala Thr Asp Thr Glu Glu Val His 
        675                 680                 685             


Ile Met Leu Asp Gly Leu Leu Pro Ser Asp Thr Tyr Phe Arg Phe Asn 
    690                 695                 700                 


Pro Val Ile Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asp Glu Lys 
705                 710                 715                 720 


Leu Asp Gln Leu Gln Leu Glu Gly Met Lys Tyr Ile Glu Arg Asn Asp 
                725                 730                 735     


Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys Thr Thr 
            740                 745                 750         


Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Ser Asp Met Tyr Glu 
        755                 760                 765             


Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775     


<210>  130
<211>  346
<212>  PRT
<213>  Mus musculus

<400>  130

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Arg Phe Leu Glu Asn 
1               5                   10                  15      


Gln Glu Gln Glu Tyr Val Gln Ala Val Lys Ser Tyr Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Ser Phe Asn Val Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Thr Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Asn Gly Lys Pro Leu Asp Glu Val Leu 
                85                  90                  95      


Arg Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Met Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Gly Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Thr Thr Arg 
    130                 135                 140                 


Ser Asn Glu Gln Ile Arg Glu Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Lys Ala Leu Leu Ala Leu Ala Lys Gly Asp Arg Cys Gln Asp Leu 
            180                 185                 190         


Ser Val Asn Gln Asp Leu Ala Asp Thr Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Thr Thr Ile 
    210                 215                 220                 


Leu Thr Ser Arg Ser Phe Pro His Leu Arg Arg Val Phe Gln Asn Tyr 
225                 230                 235                 240 


Gly Lys Tyr Ser Gln His Asp Met Asn Lys Ala Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Thr Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Thr Pro Ala Phe Phe Ala Glu Lys Leu Tyr Glu Ala Met Lys Gly 
        275                 280                 285             


Ala Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Glu Ile Lys Val Phe Tyr Gln Lys Lys Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  131
<211>  46
<212>  PRT
<213>  Macaca fascicularis

<400>  131

Gly Leu Val Thr Cys Glu Pro Gly Pro Phe Cys His Val Gln Leu Cys 
1               5                   10                  15      


Ala Cys Asp Arg Lys Leu Val Tyr Cys Leu Lys Arg Asn Leu Trp Ser 
            20                  25                  30          


Tyr Asn Pro Gln Tyr Gln Tyr Phe Pro Asn Ile Leu Cys Ser 
        35                  40                  45      


<210>  132
<211>  66
<212>  PRT
<213>  Macaca fascicularis

<400>  132

Leu Ile Leu Ala Val Ile Met Ile Phe Gly Leu Leu Gln Ala His Gly 
1               5                   10                  15      


Asn Leu Val Asp Phe Arg Arg Met Ile Lys Leu Lys Thr Gly Lys Glu 
            20                  25                  30          


Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys Gly Val Gly Gly 
        35                  40                  45              


Lys Gly Ala Pro Lys Asp Ala Thr Asp Arg Cys Cys Val Val His Asp 
    50                  55                  60                  


Cys Cys 
65      


<210>  133
<211>  89
<212>  PRT
<213>  Macaca fascicularis

<400>  133

Phe Met Leu Gly Leu Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu 
1               5                   10                  15      


Ser Asp Phe Ala Thr Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala 
            20                  25                  30          


Ala Val Ala Asp Pro Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp 
        35                  40                  45              


Val Lys Ser Lys Lys Ile His Val Val Asp Ser Gly Leu Thr Phe Asn 
    50                  55                  60                  


Leu Pro Tyr Pro Leu Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile 
65                  70                  75                  80  


Ile Ser Phe Asp Phe Ser Ala Arg Pro 
                85                  


<210>  134
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ile Met Ala Leu Ile Leu Met Asn Leu Ser Glu Tyr Met Ser Leu 
1               5                   10                  15      


Trp Met Ser Lys Val Lys Arg Phe Met 
            20                  25  


<210>  135
<211>  329
<212>  PRT
<213>  Rattus norvegicus

<400>  135

Tyr Phe Ala Thr Gly Leu Gln Glu Glu Glu Lys Gly Ala Val His Lys 
1               5                   10                  15      


Arg Ser Phe Lys Val Leu Glu Gly Leu Lys Lys Leu Asn Ile Gln Ala 
            20                  25                  30          


Asp Gln Ala Pro Val Ile Ala Val Leu Gly Ser Gly Gly Gly Leu Arg 
        35                  40                  45              


Ala His Ile Ala Cys Leu Gly Met Leu Ser Ala Met Lys Glu Leu Gly 
    50                  55                  60                  


Leu Leu Asp Ala Val Thr Tyr Leu Ala Gly Val Ser Gly Ser Thr Trp 
65                  70                  75                  80  


Ala Leu Ser Ser Phe Tyr Thr Lys Asn Gly Asn Met Gln Gly Met Glu 
                85                  90                  95      


Glu Glu Leu Lys His Arg Tyr Glu Lys Asn Glu Trp His Phe Asp Glu 
            100                 105                 110         


Ser Leu Asp Lys Ala Ile Gln Ala Ser Arg Arg Glu Asn Tyr Ser Leu 
        115                 120                 125             


Thr Asp Phe Trp Ala Tyr Leu Val Val Ser Arg Gln Thr Arg Glu Leu 
    130                 135                 140                 


His Asp Ser Asn Leu Ser Ser Phe Lys Lys Gln Val Glu Glu Gly Val 
145                 150                 155                 160 


Leu Pro Tyr Pro Ile Phe Ala Ala Ile Asp Asp Asp Leu His Asp Asp 
                165                 170                 175     


Trp Arg Glu Lys Lys Val Gln Asn Ser Trp Phe Glu Phe Thr Pro His 
            180                 185                 190         


His Ala Gly Tyr Pro Ala Leu Arg Ala Tyr Val Pro Ile Thr Glu Phe 
        195                 200                 205             


Gly Ser Arg Phe Glu Asn Gly Lys Leu Val Arg Pro Glu Pro Glu Arg 
    210                 215                 220                 


Asp Leu Thr Phe Leu Arg Gly Leu Trp Gly Ser Ala Leu Ala Asp Ile 
225                 230                 235                 240 


Lys Glu Asp Lys Ala Phe Ile Met Asp Tyr Phe Lys Asp Met Tyr Glu 
                245                 250                 255     


Lys Leu Lys Lys Lys Tyr Leu His Arg Gly Gly Ala Lys Thr Val Thr 
            260                 265                 270         


Tyr Ser Asn Ala Glu Gln Met Asp Val Asp Glu Met Phe Leu Asp Leu 
        275                 280                 285             


Leu Met Ala Tyr Ala Ile Asp Gln Asp Asp Pro Ser Ile Lys Asp Lys 
    290                 295                 300                 


Leu Cys Asp Met Gln Gln Ala Leu Gly Pro Gly Thr Gly Glu Phe Gly 
305                 310                 315                 320 


Lys Glu Met Ala Glu Ile Ile His Asn 
                325                 


<210>  136
<211>  1463
<212>  PRT
<213>  Bos taurus

<400>  136

Met Pro Leu Leu Ser Leu Ser Leu Leu Leu Leu Leu Leu Gln Val Pro 
1               5                   10                  15      


Ala Gly Ser Ala Glu Thr Ala Ala Trp Ala Val Thr Pro Glu Arg Leu 
            20                  25                  30          


Arg Glu Trp Gln Asp Lys Gly Ile Phe Ile Ile Gln Ser Glu Asn Leu 
        35                  40                  45              


Glu Lys Cys Ile Gln Ala Ser Lys Ser Thr Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Pro Pro Asn Lys Tyr Met Leu Trp Lys Trp Val Ser Asn His Arg 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Val Ser Ser 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Ile Tyr Glu Cys Asp Ser Thr His Val Ser 
            100                 105                 110         


Leu Lys Trp His Cys Asn Lys Lys Thr Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Leu Val Gln Val Lys Gln Asp Asn Thr Leu Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Leu His Lys Trp Val Ser Tyr Met Ser Gly Gly Gly Gly Ile Cys Asp 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu Tyr Thr Ile Lys Gly Asn Ala His Gly Thr 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn Gln Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asn Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Thr Glu Val Gly Cys Asp Ala Val Trp Glu Lys Asp Leu His Ser Arg 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Ala Ala Leu Leu Ser Ile Ala Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Val Arg Lys His Leu Gly Ser Glu Ala Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Arg Thr Pro Leu Asn Tyr Leu Asn Trp Lys Pro Glu Ile 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Tyr His Cys Gly Thr Phe Asn Ala Phe 
                325                 330                 335     


Met Pro Lys Ala Trp Lys Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Val Cys Lys Lys Tyr Leu Asn Pro Thr Asp His Gly Val Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


His Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Lys Lys Thr Trp Asn 
385                 390                 395                 400 


Glu Ala Leu Gln Ser Cys Gln Ser Asn Asn Ser Val Leu Thr Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser His Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Gly Ser Ser Val Thr Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Thr 
                485                 490                 495     


Leu Phe Tyr Leu Cys Lys Lys Thr Gly Leu Val Leu Ser Asp Thr Glu 
            500                 505                 510         


Ser Gly Cys Gln Lys Gly Trp Glu Arg His Gly Lys Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp His Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Ile Thr Ile Thr Ser Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Thr Lys Asp Thr Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Thr Ala Gly Gln Gln Leu Glu Pro Val Lys Tyr Thr His Trp Asn Thr 
        595                 600                 605             


Arg Gln Pro Arg Tyr Ser Gly Gly Cys Val Val Met Arg Gly Arg Ser 
    610                 615                 620                 


His Pro Gly Arg Trp Glu Val Arg Asp Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Arg Glu Lys Thr Lys Gln Glu 
                645                 650                 655     


Glu Gly Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Gln Ala Glu Glu Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Arg Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Gly Thr Pro Val Val Ser Ser Phe Leu Asp Asn Ser Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Ser Tyr Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Arg Pro Lys Val Pro Pro Trp Tyr Gln Tyr Asp Ala Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Ile Ser Ala Ser Glu 
            820                 825                 830         


Trp Ser Ser Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Ile Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Arg 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Val Asn Trp Trp Ile Gly Leu Arg Glu Glu 
865                 870                 875                 880 


Arg Ala Ser Asp Glu Phe Arg Trp Arg Asp Gly Ser Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Lys Gly Lys Glu Arg Ser Met Gly Leu Asn Glu Ser 
            900                 905                 910         


Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Ala Ser Glu 
        915                 920                 925             


Glu Cys Ser Ile Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp 
    930                 935                 940                 


Val Ile Glu Lys Lys Lys Asp Ile Pro Lys Gln His Gly Thr Cys Pro 
945                 950                 955                 960 


Lys Gly Trp Leu Tyr Phe Asp Tyr Lys Cys Leu Leu Leu Lys Ile Pro 
                965                 970                 975     


Glu Gly Pro Ser Asp Trp Lys Asn Trp Thr Ser Ala Gln Asp Phe Cys 
            980                 985                 990         


Val Glu Glu Gly Gly Thr Leu Val  Ala Ile Glu Asn Glu  Val Glu Gln 
        995                 1000                 1005             


Ala Phe  Ile Thr Met Asn Leu  Phe Gly His Thr Thr  Asn Val Trp 
    1010                 1015                 1020             


Ile Gly  Leu Gln Asp Asp Asp  Tyr Glu Lys Trp Leu  Asn Gly Arg 
    1025                 1030                 1035             


Pro Val  Ser Tyr Ser Asn Trp  Ser Pro Phe Asp Thr  Lys Asn Ile 
    1040                 1045                 1050             


Pro Asn  His Asn Thr Thr Glu  Val Gln Lys Arg Ile  Pro Leu Cys 
    1055                 1060                 1065             


Gly Leu  Leu Ser Asn Asn Pro  Asn Phe His Phe Thr  Gly Lys Trp 
    1070                 1075                 1080             


Tyr Phe  Glu Asp Cys Arg Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Ala Ser Gly His  Ser Ile Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Ile  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Thr Ala Leu Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Gly Ala Glu Leu Ala  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Ile Leu  Asn Arg Val Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Glu Asp  Asn Gly Leu Ser Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Asp Glu Ser 
    1190                 1195                 1200             


Ser Phe  Leu Gly Asp Cys Val  Phe Ala Asp Thr Ser  Gly Arg Trp 
    1205                 1210                 1215             


Ser Ser  Thr Ala Cys Glu Ser  Tyr Leu Gln Gly Ala  Ile Cys Gln 
    1220                 1225                 1230             


Val Pro  Thr Glu Thr Arg Leu  Ser Gly Arg Leu Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Glu Ser  Thr Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Lys Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ser Phe Leu Leu  Glu Glu Leu Leu Ala  Phe Arg Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Ile Trp Leu  Asn Ala Gln Phe Asp  Gly Asp Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Glu  Val Tyr His Phe Lys  Pro His Leu 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Val Trp Gln  Leu Ser Ser 
    1355                 1360                 1365             


Cys Gln  Asp Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Val Lys Lys His Pro  Gly Lys Gly Pro Ser  His Ser Val 
    1385                 1390                 1395             


Ile Pro  Leu Thr Val Ala Leu  Thr Leu Leu Val Ile  Leu Ala Ile 
    1400                 1405                 1410             


Ser Thr  Leu Ser Phe Cys Met  Tyr Lys His Ser His  Ile Ile Phe 
    1415                 1420                 1425             


Gly Arg  Leu Ala Gln Phe Arg  Asn Pro Tyr Tyr Pro  Ser Ala Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val His Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Asn Asp Gln 
    1460             


<210>  137
<211>  807
<212>  PRT
<213>  Mus musculus

<400>  137

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Leu Ile Thr Arg Lys 
385                 390                 395                 400 


Ala Leu Leu Thr Leu Leu Lys Thr Val Gly Ala Asp His His Phe Pro 
                405                 410                 415     


Ile Ile Gln Gly Val Ser Thr Glu Gln Gly Ser Ala Ala Ala Thr His 
            420                 425                 430         


Pro Leu Phe Ser Leu Asp Arg Thr Gln Pro Pro Ala Ile Ser Leu Asn 
        435                 440                 445             


Asn Leu Glu Leu Gln Asp Leu Met Pro Ile Ser Arg Ala Arg Lys Pro 
    450                 455                 460                 


Ala Phe Ile Leu Ser Ser Met Arg Asp Glu Lys Arg Ser His Asp His 
465                 470                 475                 480 


Leu Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val Ile Ile Gln 
                485                 490                 495     


Leu Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu 
            500                 505                 510         


Phe Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala 
        515                 520                 525             


Ile Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Val Tyr Phe Arg 
    530                 535                 540                 


Met Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro 
545                 550                 555                 560 


Leu Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr 
                565                 570                 575     


Asp Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg 
            580                 585                 590         


Gln Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Ala 
        595                 600                 605             


Val Arg Glu Pro Arg Cys Asn Gln Asn Ile Asn Leu Lys Pro Pro Thr 
    610                 615                 620                 


Gln Pro Ala Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala 
625                 630                 635                 640 


Ala Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu 
                645                 650                 655     


Leu Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr 
            660                 665                 670         


Asn Gln Asp Met Ile Arg Lys Gly Gln Gly Asn Lys Val Lys Lys Leu 
        675                 680                 685             


Ser Ile Val Val Ser Leu Gly Thr Gly Lys Ser Pro Gln Val Pro Val 
    690                 695                 700                 


Thr Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys 
705                 710                 715                 720 


Thr Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys 
                725                 730                 735     


Thr Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu 
            740                 745                 750         


Met Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Ser Asp 
        755                 760                 765             


Ile Met Leu Asp Glu Val Ser Asp Ala Val Leu Val Asn Ala Leu Trp 
    770                 775                 780                 


Glu Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu 
785                 790                 795                 800 


Val Gln Leu Leu Leu Ser Pro 
                805         


<210>  138
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  139
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  139

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  140
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Ser Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Ile Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Ile Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  141
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asp 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  142
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asp 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn 
545                 550                 555                 560 


Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  143
<211>  751
<212>  PRT
<213>  Rattus norvegicus

<400>  143

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Ala Lys Glu Val Ser Leu Ala Asp Tyr 
            20                  25                  30          


Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Ala Ser Asn Arg Thr Trp Asp Cys Asp Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Asp Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Val 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Glu Gln Val Leu His Val Glu Val Leu Gln Leu Thr Asp Leu 
            100                 105                 110         


Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu Leu 
        115                 120                 125             


Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Thr Cys Ala Asn 
    130                 135                 140                 


Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg 
145                 150                 155                 160 


Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Ala 
                165                 170                 175     


Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr Ala 
            180                 185                 190         


Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn Ala 
        195                 200                 205             


Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu His 
    210                 215                 220                 


Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu 
225                 230                 235                 240 


Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile His 
                245                 250                 255     


Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser 
            260                 265                 270         


Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser 
        275                 280                 285             


Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys 
    290                 295                 300                 


Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala Leu 
305                 310                 315                 320 


His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu Leu 
                325                 330                 335     


Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr Pro 
            340                 345                 350         


Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala Leu 
        355                 360                 365             


Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr 
    370                 375                 380                 


Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu Met 
385                 390                 395                 400 


Pro Val Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met Arg 
                405                 410                 415     


Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly Gly 
            420                 425                 430         


Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala 
        435                 440                 445             


Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser 
    450                 455                 460                 


Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala 
465                 470                 475                 480 


Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly 
                485                 490                 495     


Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu 
            500                 505                 510         


Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val Met 
        515                 520                 525             


Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe 
    530                 535                 540                 


Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Thr Pro 
545                 550                 555                 560 


Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val Trp 
                565                 570                 575     


Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn 
            580                 585                 590         


Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp 
        595                 600                 605             


Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys Gly 
    610                 615                 620                 


Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr 
625                 630                 635                 640 


Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg Pro 
                645                 650                 655     


Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu 
            660                 665                 670         


Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val 
        675                 680                 685             


Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg 
    690                 695                 700                 


Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser Asp 
705                 710                 715                 720 


Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu 
                725                 730                 735     


Tyr Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750     


<210>  144
<211>  1463
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  145
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn 
545                 550                 555                 560 


Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  146
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  147
<211>  1522
<212>  PRT
<213>  Mus musculus

<400>  147

Met Ala Trp Ser Ser Arg Arg Val Val Ala Ser Leu Ala Ser Cys Ser 
1               5                   10                  15      


Leu Val Gln Ser Arg Gly His Gly Ser Asp Ser Arg Gly Cys His Leu 
            20                  25                  30          


Ala Cys Leu Met Val Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu 
        35                  40                  45              


Gln Gln Leu Leu Leu Leu Gly Ile His Gln Gly Ile Ala Gln Asp Leu 
    50                  55                  60                  


Thr His Ile Gln Glu Pro Ser Leu Glu Trp Arg Asp Lys Gly Ile Phe 
65                  70                  75                  80  


Ile Ile Gln Ser Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser 
                85                  90                  95      


Val Leu Thr Leu Glu Asn Cys Lys Gln Pro Asn Glu His Met Leu Trp 
            100                 105                 110         


Lys Trp Val Ser Asp Asp His Leu Phe Asn Val Gly Gly Ser Gly Cys 
        115                 120                 125             


Leu Gly Leu Asn Ile Ser Ala Leu Glu Gln Pro Leu Lys Leu Tyr Glu 
    130                 135                 140                 


Cys Asp Ser Thr Leu Ile Ser Leu Arg Trp His Cys Asp Arg Lys Met 
145                 150                 155                 160 


Ile Glu Gly Pro Leu Gln Tyr Lys Val Gln Val Lys Ser Asp Asn Thr 
                165                 170                 175     


Val Val Ala Arg Lys Gln Ile His Arg Trp Ile Ala Tyr Thr Ser Ser 
            180                 185                 190         


Gly Gly Asp Ile Cys Glu His Pro Ser Arg Asp Leu Tyr Thr Leu Lys 
        195                 200                 205             


Gly Asn Ala His Gly Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly 
    210                 215                 220                 


His Trp His His Asp Cys Ile Arg Glu Gly Gln Lys Glu His Leu Leu 
225                 230                 235                 240 


Trp Cys Ala Thr Thr Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe 
                245                 250                 255     


Cys Pro Asp Pro Thr Ser Met Lys Val Phe Cys Asp Ala Thr Trp Gln 
            260                 265                 270         


Arg Asn Gly Ser Ser Arg Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser 
        275                 280                 285             


Leu Ser Trp Asn Gln Ala His Ser Ser Cys Leu Met Gln Gly Gly Ala 
    290                 295                 300                 


Leu Leu Ser Ile Ala Asp Glu Asp Glu Glu Asp Phe Ile Arg Lys His 
305                 310                 315                 320 


Leu Ser Lys Val Val Lys Glu Val Trp Ile Gly Leu Asn Gln Leu Asp 
                325                 330                 335     


Glu Lys Ala Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu 
            340                 345                 350         


Asn Trp Ser Gln Glu Ile Thr Pro Gly Pro Phe Val Glu His His Cys 
        355                 360                 365             


Gly Thr Leu Glu Val Val Ser Ala Ala Trp Arg Ser Arg Asp Cys Glu 
    370                 375                 380                 


Ser Thr Leu Pro Tyr Ile Cys Lys Arg Asp Leu Asn His Thr Ala Gln 
385                 390                 395                 400 


Gly Ile Leu Glu Lys Asp Ser Trp Lys Tyr His Ala Thr His Cys Asp 
                405                 410                 415     


Pro Asp Trp Thr Pro Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Asp 
            420                 425                 430         


Arg Lys Ser Trp Leu Gly Ala Leu His Ser Cys Gln Ser Asn Asp Ser 
        435                 440                 445             


Val Leu Met Asp Val Ala Ser Leu Ala Glu Val Glu Phe Leu Val Ser 
    450                 455                 460                 


Leu Leu Arg Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser 
465                 470                 475                 480 


Asn Lys Ile Pro Val Ser Phe Glu Trp Ser Ser Gly Ser Ser Val Ile 
                485                 490                 495     


Phe Thr Asn Trp Tyr Pro Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg 
            500                 505                 510         


Gln Leu Cys Val Ser Ala Glu Glu Ser Asp Gly Arg Trp Lys Val Lys 
        515                 520                 525             


Asp Cys Lys Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly Gln Val 
    530                 535                 540                 


Pro Ala Asp Glu Gln Ser Gly Cys Pro Ala Gly Trp Glu Arg His Gly 
545                 550                 555                 560 


Arg Phe Cys Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Glu Glu Ala 
                565                 570                 575     


Ser Ser Gly Tyr Tyr Cys Ser Pro Ala Leu Leu Thr Ile Thr Ser Arg 
            580                 585                 590         


Phe Glu Gln Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Ala Glu Lys 
        595                 600                 605             


Asp Ser Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu 
    610                 615                 620                 


Tyr Thr Trp Lys Thr Val Gly Gln Arg Glu Pro Val Gln Tyr Thr Tyr 
625                 630                 635                 640 


Trp Asn Thr Arg Gln Pro Ser Asn Arg Gly Gly Cys Val Val Val Arg 
                645                 650                 655     


Gly Gly Ser Ser Leu Gly Arg Trp Glu Val Lys Asp Cys Ser Asp Phe 
            660                 665                 670         


Lys Ala Met Ser Leu Cys Lys Thr Pro Val Lys Ile Trp Glu Lys Thr 
        675                 680                 685             


Glu Leu Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu 
    690                 695                 700                 


Ser Ala Thr Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys 
705                 710                 715                 720 


Val Leu Met Lys Arg Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu 
                725                 730                 735     


Phe Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe 
            740                 745                 750         


Val Asn Glu Leu Leu His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln 
        755                 760                 765             


Phe Trp Ile Gly Phe Asn Arg Arg Asn Pro Leu Asn Ala Gly Ser Trp 
    770                 775                 780                 


Ala Trp Ser Asp Gly Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala 
785                 790                 795                 800 


Tyr Phe Glu Glu Asp Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Lys 
                805                 810                 815     


Thr Leu Leu Pro Ser Asn Cys Ala Ser Lys His Glu Trp Ile Cys Arg 
            820                 825                 830         


Ile Pro Arg Asp Val Arg Pro Lys Phe Pro Asp Trp Tyr Gln Tyr Asp 
        835                 840                 845             


Ala Pro Trp Leu Phe Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His 
    850                 855                 860                 


Pro Ala Glu Trp Ala Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser 
865                 870                 875                 880 


Asp Phe Leu Thr Ile Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser 
                885                 890                 895     


Lys Ile Lys Gly Leu Thr Lys Tyr Gly Val Lys Trp Trp Ile Gly Leu 
            900                 905                 910         


Glu Glu Gly Gly Ala Arg Asp Gln Ile Gln Trp Ser Asn Gly Ser Pro 
        915                 920                 925             


Val Ile Phe Gln Asn Trp Asp Lys Gly Arg Glu Glu Arg Val Asp Ser 
    930                 935                 940                 


Gln Arg Lys Arg Cys Val Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly 
945                 950                 955                 960 


Thr Glu Asn Cys Ser Val Pro Leu Pro Ser Ile Cys Lys Arg Val Lys 
                965                 970                 975     


Ile Trp Val Ile Glu Lys Glu Lys Pro Pro Thr Gln Pro Gly Thr Cys 
            980                 985                 990         


Pro Lys Gly Trp Leu Tyr Phe Asn  Tyr Lys Cys Phe Leu  Val Thr Ile 
        995                 1000                 1005             


Pro Lys  Asp Pro Arg Glu Leu  Lys Thr Trp Thr Gly  Ala Gln Glu 
    1010                 1015                 1020             


Phe Cys  Val Ala Lys Gly Gly  Thr Leu Val Ser Ile  Lys Ser Glu 
    1025                 1030                 1035             


Leu Glu  Gln Ala Phe Ile Thr  Met Asn Leu Phe Gly  Gln Thr Thr 
    1040                 1045                 1050             


Asn Val  Trp Ile Gly Leu Gln  Ser Thr Asn His Glu  Lys Trp Val 
    1055                 1060                 1065             


Asn Gly  Lys Pro Leu Val Tyr  Ser Asn Trp Ser Pro  Ser Asp Ile 
    1070                 1075                 1080             


Ile Asn  Ile Pro Ser Tyr Asn  Thr Thr Glu Phe Gln  Lys His Ile 
    1085                 1090                 1095             


Pro Leu  Cys Ala Leu Met Ser  Ser Asn Pro Asn Phe  His Phe Thr 
    1100                 1105                 1110             


Gly Lys  Trp Tyr Phe Asp Asp  Cys Gly Lys Glu Gly  Tyr Gly Phe 
    1115                 1120                 1125             


Val Cys  Glu Lys Met Gln Asp  Thr Leu Glu His His  Val Asn Val 
    1130                 1135                 1140             


Ser Asp  Thr Ser Ala Ile Pro  Ser Thr Leu Glu Tyr  Gly Asn Arg 
    1145                 1150                 1155             


Thr Tyr  Lys Ile Ile Arg Gly  Asn Met Thr Trp Tyr  Ala Ala Gly 
    1160                 1165                 1170             


Lys Ser  Cys Arg Met His Arg  Ala Glu Leu Ala Ser  Ile Pro Asp 
    1175                 1180                 1185             


Ala Phe  His Gln Ala Phe Leu  Thr Val Leu Leu Ser  Arg Leu Gly 
    1190                 1195                 1200             


His Thr  His Trp Ile Gly Leu  Ser Thr Thr Asp Asn  Gly Gln Thr 
    1205                 1210                 1215             


Phe Asp  Trp Ser Asp Gly Thr  Lys Ser Pro Phe Thr  Tyr Trp Lys 
    1220                 1225                 1230             


Asp Glu  Glu Ser Ala Phe Leu  Gly Asp Cys Ala Phe  Ala Asp Thr 
    1235                 1240                 1245             


Asn Gly  Arg Trp His Ser Thr  Ala Cys Glu Ser Phe  Leu Gln Gly 
    1250                 1255                 1260             


Ala Ile  Cys His Val Val Thr  Glu Thr Lys Ala Phe  Glu His Pro 
    1265                 1270                 1275             


Gly Leu  Cys Ser Glu Thr Ser  Val Pro Trp Ile Lys  Phe Lys Gly 
    1280                 1285                 1290             


Asn Cys  Tyr Ser Phe Ser Thr  Val Leu Asp Ser Arg  Ser Phe Glu 
    1295                 1300                 1305             


Asp Ala  His Glu Phe Cys Lys  Ser Glu Gly Ser Asn  Leu Leu Ala 
    1310                 1315                 1320             


Ile Arg  Asp Ala Ala Glu Asn  Ser Phe Leu Leu Glu  Glu Leu Leu 
    1325                 1330                 1335             


Ala Phe  Gly Ser Ser Val Gln  Met Val Trp Leu Asn  Ala Gln Phe 
    1340                 1345                 1350             


Asp Asn  Asn Asn Lys Thr Leu  Arg Trp Phe Asp Gly  Thr Pro Thr 
    1355                 1360                 1365             


Glu Gln  Ser Asn Trp Gly Leu  Arg Lys Pro Asp Met  Asp His Leu 
    1370                 1375                 1380             


Lys Pro  His Pro Cys Val Val  Leu Arg Ile Pro Glu  Gly Ile Trp 
    1385                 1390                 1395             


His Phe  Thr Pro Cys Glu Asp  Lys Lys Gly Phe Ile  Cys Lys Met 
    1400                 1405                 1410             


Glu Ala  Gly Ile Pro Ala Val  Thr Ala Gln Pro Glu  Lys Gly Leu 
    1415                 1420                 1425             


Ser His  Ser Ile Val Pro Val  Thr Val Thr Leu Thr  Leu Ile Ile 
    1430                 1435                 1440             


Ala Leu  Gly Ile Phe Met Leu  Cys Phe Trp Ile Tyr  Lys Gln Lys 
    1445                 1450                 1455             


Ser Asp  Ile Phe Gln Arg Leu  Thr Gly Ser Arg Gly  Ser Tyr Tyr 
    1460                 1465                 1470             


Pro Thr  Leu Asn Phe Ser Thr  Ala His Leu Glu Glu  Asn Ile Leu 
    1475                 1480                 1485             


Ile Ser  Asp Leu Glu Lys Asn  Thr Asn Asp Glu Glu  Val Arg Asp 
    1490                 1495                 1500             


Ala Pro  Ala Thr Glu Ser Lys  Arg Gly His Lys Gly  Arg Pro Ile 
    1505                 1510                 1515             


Cys Ile  Ser Pro 
    1520         


<210>  148
<211>  1522
<212>  PRT
<213>  Mus musculus

<400>  148

Met Ala Trp Ser Ser Arg Arg Val Val Ala Ser Leu Ala Ser Cys Ser 
1               5                   10                  15      


Leu Val Gln Ser Arg Gly His Gly Ser Asp Ser Arg Gly Cys His Leu 
            20                  25                  30          


Ala Cys Leu Met Val Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu 
        35                  40                  45              


Gln Gln Leu Leu Leu Leu Gly Ile His Gln Gly Ile Ala Gln Asp Leu 
    50                  55                  60                  


Thr His Ile Gln Glu Pro Ser Leu Glu Trp Arg Asp Lys Gly Ile Phe 
65                  70                  75                  80  


Ile Ile Gln Ser Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser 
                85                  90                  95      


Val Leu Thr Leu Glu Asn Cys Lys Gln Pro Asn Glu His Met Leu Trp 
            100                 105                 110         


Lys Trp Val Ser Asp Asp His Leu Phe Asn Val Gly Gly Ser Gly Cys 
        115                 120                 125             


Leu Gly Leu Asn Ile Ser Ala Leu Glu Gln Pro Leu Lys Leu Tyr Glu 
    130                 135                 140                 


Cys Asp Ser Thr Leu Ile Ser Leu Arg Trp His Cys Asp Arg Lys Met 
145                 150                 155                 160 


Ile Glu Gly Pro Leu Gln Tyr Lys Val Gln Val Lys Ser Asp Asn Thr 
                165                 170                 175     


Val Val Ala Arg Lys Gln Ile His Arg Trp Ile Ala Tyr Thr Ser Ser 
            180                 185                 190         


Gly Gly Asp Ile Cys Glu His Pro Ser Arg Asp Leu Tyr Thr Leu Lys 
        195                 200                 205             


Gly Asn Ala His Gly Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly 
    210                 215                 220                 


His Trp His His Asp Cys Ile Arg Glu Gly Gln Lys Glu His Leu Leu 
225                 230                 235                 240 


Trp Cys Ala Thr Thr Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe 
                245                 250                 255     


Cys Pro Asp Pro Thr Ser Met Lys Val Phe Cys Asp Ala Thr Trp Gln 
            260                 265                 270         


Arg Asn Gly Ser Ser Arg Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser 
        275                 280                 285             


Leu Ser Trp Asn Gln Ala His Ser Ser Cys Leu Met Gln Gly Gly Ala 
    290                 295                 300                 


Leu Leu Ser Ile Ala Asp Glu Asp Glu Glu Asp Phe Ile Arg Lys His 
305                 310                 315                 320 


Leu Ser Lys Val Val Lys Glu Val Trp Ile Gly Leu Asn Gln Leu Asp 
                325                 330                 335     


Glu Lys Ala Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu 
            340                 345                 350         


Asn Trp Ser Gln Glu Ile Thr Pro Gly Pro Phe Val Glu His His Cys 
        355                 360                 365             


Gly Thr Leu Glu Val Val Ser Ala Ala Trp Arg Ser Arg Asp Cys Glu 
    370                 375                 380                 


Ser Thr Leu Pro Tyr Ile Cys Lys Arg Asp Leu Asn His Thr Ala Gln 
385                 390                 395                 400 


Gly Ile Leu Glu Lys Asp Ser Trp Lys Tyr His Ala Thr His Cys Asp 
                405                 410                 415     


Pro Asp Trp Thr Pro Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Asp 
            420                 425                 430         


Arg Lys Ser Trp Leu Gly Ala Leu His Ser Cys Gln Ser Asn Asp Ser 
        435                 440                 445             


Val Leu Met Asp Val Ala Ser Leu Ala Glu Val Glu Phe Leu Val Ser 
    450                 455                 460                 


Leu Leu Arg Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser 
465                 470                 475                 480 


Asn Lys Ile Pro Val Ser Phe Glu Trp Ser Ser Gly Ser Ser Val Ile 
                485                 490                 495     


Phe Thr Asn Trp Tyr Pro Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg 
            500                 505                 510         


Gln Leu Cys Val Ser Ala Glu Glu Ser Asp Gly Arg Trp Lys Val Lys 
        515                 520                 525             


Asp Cys Lys Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly Gln Val 
    530                 535                 540                 


Pro Ala Asp Glu Gln Ser Gly Cys Pro Ala Gly Trp Glu Arg His Gly 
545                 550                 555                 560 


Arg Phe Cys Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Glu Glu Ala 
                565                 570                 575     


Ser Ser Gly Tyr Tyr Cys Ser Pro Ala Leu Leu Thr Ile Thr Ser Arg 
            580                 585                 590         


Phe Glu Gln Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Ala Glu Lys 
        595                 600                 605             


Asp Ser Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu 
    610                 615                 620                 


Tyr Thr Trp Lys Thr Val Gly Gln Arg Glu Pro Val Gln Tyr Thr Tyr 
625                 630                 635                 640 


Trp Asn Thr Arg Gln Pro Ser Asn Arg Gly Gly Cys Val Val Val Arg 
                645                 650                 655     


Gly Gly Ser Ser Leu Gly Arg Trp Glu Val Lys Asp Cys Ser Asp Phe 
            660                 665                 670         


Lys Ala Met Ser Leu Cys Lys Thr Pro Val Lys Ile Trp Glu Lys Thr 
        675                 680                 685             


Glu Leu Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu 
    690                 695                 700                 


Ser Ala Thr Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys 
705                 710                 715                 720 


Val Leu Met Lys Arg Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu 
                725                 730                 735     


Phe Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe 
            740                 745                 750         


Val Asn Glu Leu Leu His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln 
        755                 760                 765             


Phe Trp Ile Gly Phe Asn Arg Arg Asn Pro Leu Asn Ala Gly Ser Trp 
    770                 775                 780                 


Ala Trp Ser Asp Gly Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala 
785                 790                 795                 800 


Tyr Phe Glu Glu Asp Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Lys 
                805                 810                 815     


Thr Leu Leu Pro Ser Asn Cys Ala Ser Lys His Glu Trp Ile Cys Arg 
            820                 825                 830         


Ile Pro Arg Asp Val Arg Pro Lys Phe Pro Asp Trp Tyr Gln Tyr Asp 
        835                 840                 845             


Ala Pro Trp Leu Phe Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His 
    850                 855                 860                 


Pro Ala Glu Trp Ala Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser 
865                 870                 875                 880 


Asp Phe Leu Thr Ile Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser 
                885                 890                 895     


Lys Ile Lys Gly Leu Thr Lys Tyr Gly Val Lys Trp Trp Ile Gly Leu 
            900                 905                 910         


Glu Glu Gly Gly Ala Arg Asp Gln Ile Gln Trp Ser Asn Gly Ser Pro 
        915                 920                 925             


Val Ile Phe Gln Asn Trp Asp Lys Gly Arg Glu Glu Arg Val Asp Ser 
    930                 935                 940                 


Gln Arg Lys Arg Cys Val Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly 
945                 950                 955                 960 


Thr Glu Asn Cys Ser Val Pro Leu Pro Ser Ile Cys Lys Arg Val Lys 
                965                 970                 975     


Ile Trp Val Ile Glu Lys Glu Lys Pro Pro Thr Gln Pro Gly Thr Cys 
            980                 985                 990         


Pro Lys Gly Trp Leu Tyr Phe Asn  Tyr Lys Cys Phe Leu  Val Thr Ile 
        995                 1000                 1005             


Pro Lys  Asp Pro Arg Glu Leu  Lys Thr Trp Thr Gly  Ala Gln Glu 
    1010                 1015                 1020             


Phe Cys  Val Ala Lys Gly Gly  Thr Leu Val Ser Ile  Lys Ser Glu 
    1025                 1030                 1035             


Leu Glu  Gln Ala Phe Ile Thr  Met Asn Leu Phe Gly  Gln Thr Thr 
    1040                 1045                 1050             


Asn Val  Trp Ile Gly Leu Gln  Ser Thr Asn His Glu  Lys Trp Val 
    1055                 1060                 1065             


Asn Gly  Lys Pro Leu Val Tyr  Ser Asn Trp Ser Pro  Ser Asp Ile 
    1070                 1075                 1080             


Ile Asn  Ile Pro Ser Tyr Asn  Thr Thr Glu Phe Gln  Lys His Ile 
    1085                 1090                 1095             


Pro Leu  Cys Ala Leu Met Ser  Ser Asn Pro Asn Phe  His Phe Thr 
    1100                 1105                 1110             


Gly Lys  Trp Tyr Phe Asp Asp  Cys Gly Lys Glu Gly  Tyr Gly Phe 
    1115                 1120                 1125             


Val Cys  Glu Lys Met Gln Asp  Thr Leu Glu His His  Val Asn Val 
    1130                 1135                 1140             


Ser Asp  Thr Ser Ala Ile Pro  Ser Thr Leu Glu Tyr  Gly Asn Arg 
    1145                 1150                 1155             


Thr Tyr  Lys Ile Ile Arg Gly  Asn Met Thr Trp Tyr  Ala Ala Gly 
    1160                 1165                 1170             


Lys Ser  Cys Arg Met His Arg  Ala Glu Leu Ala Ser  Ile Pro Asp 
    1175                 1180                 1185             


Ala Phe  His Gln Ala Phe Leu  Thr Val Leu Leu Ser  Arg Leu Gly 
    1190                 1195                 1200             


His Thr  His Trp Ile Gly Leu  Ser Thr Thr Asp Asn  Gly Gln Thr 
    1205                 1210                 1215             


Phe Asp  Trp Ser Asp Gly Thr  Lys Ser Pro Phe Thr  Tyr Trp Lys 
    1220                 1225                 1230             


Asp Glu  Glu Ser Ala Phe Leu  Gly Asp Cys Ala Phe  Ala Asp Thr 
    1235                 1240                 1245             


Asn Gly  Arg Trp His Ser Thr  Ala Cys Glu Ser Phe  Leu Gln Gly 
    1250                 1255                 1260             


Ala Ile  Cys His Val Val Thr  Glu Thr Lys Ala Phe  Glu His Pro 
    1265                 1270                 1275             


Gly Leu  Cys Ser Glu Thr Ser  Val Pro Trp Ile Lys  Phe Lys Gly 
    1280                 1285                 1290             


Asn Cys  Tyr Ser Phe Ser Thr  Val Leu Asp Ser Arg  Ser Phe Glu 
    1295                 1300                 1305             


Asp Ala  His Glu Phe Cys Lys  Ser Glu Gly Ser Asn  Leu Leu Ala 
    1310                 1315                 1320             


Ile Arg  Asp Ala Ala Glu Asn  Ser Phe Leu Leu Glu  Glu Leu Leu 
    1325                 1330                 1335             


Ala Phe  Gly Ser Ser Val Gln  Met Val Trp Leu Asn  Ala Gln Phe 
    1340                 1345                 1350             


Asp Asn  Asn Asn Lys Thr Leu  Arg Trp Phe Asp Gly  Thr Pro Thr 
    1355                 1360                 1365             


Glu Gln  Ser Asn Trp Gly Leu  Arg Lys Pro Asp Met  Asp His Leu 
    1370                 1375                 1380             


Lys Pro  His Pro Cys Val Val  Leu Arg Ile Pro Glu  Gly Ile Trp 
    1385                 1390                 1395             


His Phe  Thr Pro Cys Glu Asp  Lys Lys Gly Phe Ile  Cys Lys Met 
    1400                 1405                 1410             


Glu Ala  Gly Ile Pro Ala Val  Thr Ala Gln Pro Glu  Lys Gly Leu 
    1415                 1420                 1425             


Ser His  Ser Ile Val Pro Val  Thr Val Thr Leu Thr  Leu Ile Ile 
    1430                 1435                 1440             


Ala Leu  Gly Ile Phe Met Leu  Cys Phe Trp Ile Tyr  Lys Gln Lys 
    1445                 1450                 1455             


Ser Asp  Ile Phe Gln Arg Leu  Thr Gly Ser Arg Gly  Ser Tyr Tyr 
    1460                 1465                 1470             


Pro Thr  Leu Asn Phe Ser Thr  Ala His Leu Glu Glu  Asn Ile Leu 
    1475                 1480                 1485             


Ile Ser  Asp Leu Glu Lys Asn  Thr Asn Asp Glu Glu  Val Arg Asp 
    1490                 1495                 1500             


Ala Pro  Ala Thr Glu Ser Lys  Arg Gly His Lys Gly  Arg Pro Ile 
    1505                 1510                 1515             


Cys Ile  Ser Pro 
    1520         


<210>  149
<211>  390
<212>  PRT
<213>  Mus musculus

<400>  149

Met Gly Ala Gly Gln Ser Val Cys Phe Pro Pro Ile Ser Gly Pro His 
1               5                   10                  15      


His Ile Gly Cys Thr Asp Val Met Glu Gly His Ser Leu Glu Gly Ser 
            20                  25                  30          


Leu Phe Arg Leu Phe Tyr Pro Cys Gln Ala Ser Glu Lys Cys Glu Gln 
        35                  40                  45              


Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Ser Met Gly Leu Ala Asp Tyr 
    50                  55                  60                  


Leu Gln Tyr Asn Lys Arg Trp Val Gly Leu Leu Phe Asn Val Gly Ile 
65                  70                  75                  80  


Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Ala Lys 
                85                  90                  95      


Glu Ser Gly Tyr Pro Leu Ile Ile Leu Ser His Gly Leu Gly Gly Phe 
            100                 105                 110         


Arg Ala Ser Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly Phe 
        115                 120                 125             


Val Val Ala Ala Val Glu His Arg Asp Gln Ser Ala Ala Ala Thr Tyr 
    130                 135                 140                 


Phe Cys Lys Pro Thr Ser Gln Glu Ser Ser Pro Ala Glu Ser Leu Glu 
145                 150                 155                 160 


Glu Glu Trp Leu Pro Phe Arg Arg Ile Lys Glu Gly Glu Lys Glu Phe 
                165                 170                 175     


His Val Arg Asn Pro Gln Val His Gln Arg Val Lys Glu Cys Val Arg 
            180                 185                 190         


Val Leu Arg Ile Leu Gln Asp Ala Ser Ala Gly Lys Thr Val Val Asn 
        195                 200                 205             


Val Phe Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Ser Val Asp 
    210                 215                 220                 


Thr Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala Thr Ala 
225                 230                 235                 240 


Val Leu Ala Leu Thr Gln Glu Val Gln Phe Arg Cys Ala Ile Ala Leu 
                245                 250                 255     


Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys Ala Arg 
            260                 265                 270         


Gly Pro Val Phe Phe Ile Asn Val Glu Lys Phe Gln Thr Val Glu Ser 
        275                 280                 285             


Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser Arg Ile 
    290                 295                 300                 


Val Thr Val Leu Gly Ala Val His Arg Ser Gln Thr Asp Phe Ala Phe 
305                 310                 315                 320 


Val Thr Gly Asn Leu Ile Ala Lys Phe Phe Ser Ser Asn Ser Arg Gly 
                325                 330                 335     


Thr Leu Asp Pro Tyr Glu Ser Gln Glu Val Met Val Arg Ala Ile Leu 
            340                 345                 350         


Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asp Gln Trp 
        355                 360                 365             


Ser Ser Phe Ile Glu Gly Val Gly Pro Ser Leu Ile Gln Gly Ala Pro 
    370                 375                 380                 


His Tyr Leu Ser Ser Leu 
385                 390 


<210>  150
<211>  390
<212>  PRT
<213>  Rattus norvegicus

<400>  150

Met Gly Ala Gly Gln Ser Ile Cys Phe Pro Pro Ile Ser Gly Pro His 
1               5                   10                  15      


His Ile Gly Cys Thr Asp Val Met Glu Gly His Ser Leu Glu Gly Ser 
            20                  25                  30          


Leu Phe Arg Leu Phe Tyr Pro Cys Glu Ala Ser Glu Thr Cys Glu Gln 
        35                  40                  45              


Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Val Gly Leu Ala Asp Tyr 
    50                  55                  60                  


Leu Gln Tyr Asn Lys Arg Trp Val Gly Leu Leu Phe Asn Val Gly Ile 
65                  70                  75                  80  


Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr Lys 
                85                  90                  95      


Glu Ser Gly Tyr Pro Leu Ile Ile Leu Ser His Gly Leu Gly Gly Phe 
            100                 105                 110         


Arg Val Ser Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly Phe 
        115                 120                 125             


Val Val Ala Ala Ile Glu His Arg Asp Gln Ser Ala Ala Ala Thr Tyr 
    130                 135                 140                 


Phe Cys Lys Gln Thr Ser Gln Glu Ser Ser Pro Thr Glu Ser Leu Glu 
145                 150                 155                 160 


Glu Glu Trp Ile Pro Phe Arg Arg Ile Lys Glu Gly Glu Lys Glu Phe 
                165                 170                 175     


His Val Arg Asn Pro Gln Val His Gln Arg Ala Lys Glu Cys Val Arg 
            180                 185                 190         


Val Leu Gln Ile Leu Gln Asp Ala Ser Ala Gly Lys Pro Val Ile Asn 
        195                 200                 205             


Val Phe Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Ser Ile Asp 
    210                 215                 220                 


Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala Thr Ala 
225                 230                 235                 240 


Ile Leu Ala Leu Thr Gln Glu Ala Gln Phe Arg Cys Ala Ile Ala Leu 
                245                 250                 255     


Asp Ala Trp Met Phe Pro Leu Glu His Asp Phe Tyr Pro Lys Ala Arg 
            260                 265                 270         


Gly Pro Val Phe Phe Ile Asn Val Glu Lys Phe Gln Thr Val Glu Ser 
        275                 280                 285             


Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser Arg Ile 
    290                 295                 300                 


Val Thr Val Leu Gly Ala Val His Arg Ser Gln Thr Asp Phe Ala Phe 
305                 310                 315                 320 


Val Thr Gly Asn Met Ile Gly Lys Leu Phe Ser Ser Gly Thr Arg Gly 
                325                 330                 335     


Thr Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala Met Leu 
            340                 345                 350         


Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asp Gln Trp 
        355                 360                 365             


Asn Ser Phe Ile Glu Gly Ile Gly Pro Ser Leu Ile Gln Gly Ala Pro 
    370                 375                 380                 


His Tyr Leu Ser Ser Leu 
385                 390 


<210>  151
<211>  392
<212>  PRT
<213>  Bos taurus

<400>  151

Met Gly Val Asn Gln Ser Val Ser Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Ser Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Glu Ala Glu Glu Thr Ser Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Ala Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Lys Phe Asn Lys Arg Trp Gly Gly Leu Leu Phe Asn Leu Gly 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Met Gly Ala 
            100                 105                 110         


Phe Arg Thr Val Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Gly Ser Ala Ala Ala Thr 
    130                 135                 140                 


Cys Phe Cys Lys Gln Thr Pro Glu Glu Asn Gln Pro Asp Asn Glu Ala 
145                 150                 155                 160 


Leu Lys Glu Glu Trp Ile Pro His Arg Gln Ile Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe Tyr Val Arg Asn Tyr Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Val Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Ala Val 
        195                 200                 205             


Leu Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Gly 
    210                 215                 220                 


Ile Asp Val Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Met Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu His Asp Phe Tyr Pro Thr 
            260                 265                 270         


Ala Arg Gly Pro Ile Phe Phe Ile Asn Ala Glu Lys Phe Gln Thr Val 
        275                 280                 285             


Glu Thr Val Asn Leu Met Lys Lys Ile Cys Asp Gln His His Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Leu Thr Asp Phe 
305                 310                 315                 320 


Val Phe Val Ala Gly Asn Trp Ile Ser Lys Phe Phe Ser Ser His Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Thr Val Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asp 
        355                 360                 365             


Gln Trp Asn Asn Phe Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210>  152
<211>  436
<212>  PRT
<213>  Cavia porcellus

<400>  152

Met Ala Pro Pro Lys Leu His Thr Leu Phe Cys Leu Ser Gly Phe Leu 
1               5                   10                  15      


Ala Leu Val His Pro Phe Asp Trp Arg Asp Leu Asp Pro Val Thr Tyr 
            20                  25                  30          


Ile Gln Ser Ser Val Trp Ile Gln Arg Ile Gln Ser Glu Leu Leu Ile 
        35                  40                  45              


Thr Ser Phe Gly His Thr Thr Ile Pro Lys Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Ser Gly Tyr Thr Asn Gln Ser Ser Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Phe Pro Asp Ala Leu 
                85                  90                  95      


Trp Ile Pro Asn Glu Glu Tyr Phe Gln Gly Leu Thr Glu Thr Leu Gly 
            100                 105                 110         


Ala Ser Ser Phe Leu Gly Lys Leu Leu Lys Leu Leu Tyr Gly Ser Val 
        115                 120                 125             


Lys Val Pro Ala Lys Trp Asn Ser Pro Leu Lys Thr Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala Phe Arg Ser Ile Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Glu Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Glu Ser Ala Ala Ala Thr Tyr Tyr Phe Gln Asp 
            180                 185                 190         


Ala Pro Ala Ala Glu Ser Gly Asn Arg Ser Trp Ile Tyr Tyr Lys Val 
        195                 200                 205             


Gly Asn Leu Glu Thr Glu Glu Arg Lys Arg Gln Leu Arg Gln Arg Gly 
    210                 215                 220                 


Glu Glu Cys Ser Gln Ala Leu Ser Trp Leu Leu Ser Ile Asp Glu Gly 
225                 230                 235                 240 


Glu Pro Val Lys Asn Val Leu Asp Leu Asn Phe Asp Ile Gln Gln Leu 
                245                 250                 255     


Lys Gly Ser Leu Asp Arg Ser Lys Val Ala Ile Ile Gly His Ser Phe 
            260                 265                 270         


Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg Phe Arg 
        275                 280                 285             


Cys Gly Ile Ala Leu Asp Pro Trp Met Phe Pro Val Gly Glu Asp Val 
    290                 295                 300                 


His Ser Lys Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu Tyr Phe 
305                 310                 315                 320 


Gln Ser Ala Asn Asp Thr Lys Lys Ile Glu Lys Phe Tyr Gln Pro Gln 
                325                 330                 335     


Lys Glu Arg Lys Met Ile Ala Val Lys Gly Ser Val His His Asn Phe 
            340                 345                 350         


Val Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly Gln Met Leu Ser 
        355                 360                 365             


Leu Lys Gly Lys Ile Asp Ser Glu Val Ala Met Asp Leu Ile Asn Lys 
    370                 375                 380                 


Ala Ser Leu Ala Phe Leu Gln Lys Tyr Leu Gly Leu Asp Lys Asn Phe 
385                 390                 395                 400 


Asp Gln Trp Asn Ser Leu Met Glu Gly Asp Asp Glu Asn Leu Ile Pro 
                405                 410                 415     


Glu Phe Thr Ile Pro Thr Thr Met Gln Ser Ser Thr Gly Thr Glu Gln 
            420                 425                 430         


Arg Asn Pro Asp 
        435     


<210>  153
<211>  752
<212>  PRT
<213>  Equus caballus

<400>  153

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Asn Ser Val Ser Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Ser Ser Ser Ser Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Leu His Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Lys Ser Gly Phe Arg Leu Phe Gln Leu Glu Val Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Leu Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Ser Gln Val Leu His Ala Glu Val Leu Gln Gln Leu Ser Asp 
            100                 105                 110         


Leu Ile Arg Ser His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Val Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Val Glu Asn Glu Gly Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Ser Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Arg Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Ala Asn Asn Gln Gly Gln Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Cys Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro His Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asn Asn Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala His Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Ser Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Leu Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Thr Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Ile Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Cys Leu Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Glu Ala Pro Glu Cys Val Arg Glu Pro Arg Phe Ser 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Asp Ser Lys Val Lys Lys Leu Ser Val Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Ser Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Pro Lys Thr Val Leu Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Ile Asn 
705                 710                 715                 720 


Asp Ser Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Gln Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  154
<211>  806
<212>  PRT
<213>  Equus caballus

<400>  154

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Asn Ser Val Ser Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Ser Ser Ser Ser Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Leu His Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Lys Ser Gly Phe Arg Leu Phe Gln Leu Glu Val Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Leu Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Ser Gln Val Leu His Ala Glu Val Leu Gln Gln Leu Ser Asp 
            100                 105                 110         


Leu Ile Arg Ser His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Val Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Val Glu Asn Glu Gly Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Ser Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Arg Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Ala Asn Asn Gln Gly Gln Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Cys Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro His Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asn Asn Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala His Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Ser Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Leu Ala Ser Lys Ile Ser Lys Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Leu Leu Thr Leu Leu Arg Thr Val Gly Ala Asp Cys Gln Leu Pro 
                405                 410                 415     


Leu Val Ser Val Val Pro Val Gln Gln Gly Ser Ala Ala Ala His His 
            420                 425                 430         


Arg Val Ser Leu Glu Arg Ser Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Thr 
    450                 455                 460                 


Phe Ile Leu Ser Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Ile Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Cys Leu Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Glu Ala Pro Glu Cys Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Ser Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Asp Ser Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Val Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Ser Arg Pro Ser Asn Pro Trp Glu Leu Pro Lys Thr 
705                 710                 715                 720 


Val Leu Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Ile Asn Asp Ser Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Gln Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  155
<211>  779
<212>  PRT
<213>  Equus caballus

<400>  155

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Leu Tyr Gly Lys Gln Arg Ser Lys Gln Leu His Phe Leu 
            20                  25                  30          


Cys Ser Pro Glu His Tyr Arg Ser Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Ala Phe His Thr Ser Lys Val Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asp His Gly Val His 
65                  70                  75                  80  


Thr Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Arg Gly Leu Thr Lys 
                85                  90                  95      


Val Ser Ile Arg Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Leu Phe Gly Lys Gln Asn Glu Met Ile Ser Cys Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Ser Val Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Val Arg Gln Ala Ile Lys Ser Leu Lys Arg Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Glu Glu Lys Ser Ser Phe Pro Glu Lys Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Asp Lys Asp Ile Asp Lys Gln Ser Leu Phe His Tyr 
            180                 185                 190         


Ser Thr Ser Ile Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Glu Glu Lys Met Ser Gln Lys 
    210                 215                 220                 


Lys Glu Asn Lys His Phe Gln Asp Asn Ser Glu Leu Glu Asp Glu Lys 
225                 230                 235                 240 


Ser Ser Ser Pro Asp Ser Gly Val Leu Thr Asp Glu Lys Gln Asp Ser 
                245                 250                 255     


Glu Ser Ser Leu His Thr Val Asp Lys Pro Ser Ser Pro Ser Gly Thr 
            260                 265                 270         


Pro Glu Val Leu Pro Val Ser Ala Lys Gln Ser Ile Ala Asn Phe Leu 
        275                 280                 285             


Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly 
    290                 295                 300                 


Gly Leu Val Pro Lys Leu Lys Tyr Asn Ser Lys Ser Gln Ser Glu Glu 
305                 310                 315                 320 


Gln Glu Glu Ala Gly Lys Ala Glu Gln Ala Val Ser Lys Asp Lys Asn 
                325                 330                 335     


Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala 
            340                 345                 350         


Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg 
        355                 360                 365             


Arg Thr Thr Asp Pro Lys Leu Cys Ile Asn Arg Val Glu Glu Leu Thr 
    370                 375                 380                 


Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu 
385                 390                 395                 400 


Lys Ile Ile Pro Cys Leu Leu Arg Leu Arg Gln Ile Lys Asp Glu Thr 
                405                 410                 415     


Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp 
            420                 425                 430         


Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ala Ile Asp Gly Gly Gly 
        435                 440                 445             


Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu 
    450                 455                 460                 


Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser 
465                 470                 475                 480 


Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu 
                485                 490                 495     


Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser 
            500                 505                 510         


Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe 
        515                 520                 525             


Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg Met Gly Ser 
    530                 535                 540                 


Ser Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val Ala 
545                 550                 555                 560 


Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe Val 
                565                 570                 575     


Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His Tyr Leu Gly 
            580                 585                 590         


Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala 
        595                 600                 605             


Pro Gly Tyr Phe Glu Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp 
    610                 615                 620                 


Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu Cys 
625                 630                 635                 640 


Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu Gly 
                645                 650                 655     


Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Ala Val Thr Tyr Thr Ser 
            660                 665                 670         


Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr Glu 
        675                 680                 685             


Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr Phe 
    690                 695                 700                 


Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg 
705                 710                 715                 720 


Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile Glu 
                725                 730                 735     


Arg Asn Glu Glu Lys Met Lys Lys Leu Ala Lys Ile Leu Ser Gln Glu 
            740                 745                 750         


Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr Asp 
        755                 760                 765             


Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 


<210>  156
<211>  1471
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  156

Met Leu Ser Gly Pro Leu Pro Ala Leu Leu Leu Gln Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gln Leu Leu His Arg Gly Pro Gly Gly Gly Cys Ser Leu Ala 
            20                  25                  30          


Gly Pro Pro Pro Val Asp Glu Pro Ala Ser Asp Leu Leu Gly Lys Gly 
        35                  40                  45              


Ile Phe Met Ile Gln Ser Asp Tyr Leu Arg Thr Cys Ile Ser Ser Gly 
    50                  55                  60                  


Lys Asn Gly Leu Val Leu Gln Asp Cys His Gln Pro Thr Lys Asn Met 
65                  70                  75                  80  


Leu Trp Lys Trp Val Ser Lys Arg His Leu Phe Asn Leu Gly Ser Ser 
                85                  90                  95      


Gly Cys Leu Gly Leu Asn Ile Ser Asn Glu Glu Gln Pro Leu Gly Leu 
            100                 105                 110         


Tyr Glu Cys Asp Ser Pro His Ser Ser Leu Trp Trp His Cys Asn Arg 
        115                 120                 125             


Lys Val Val Val Gly Ala Ser Gln Tyr Ala Leu Glu Ile Lys Asn Tyr 
    130                 135                 140                 


Asn Leu Val Val Ala Arg Arg Gln Ser Ser His Gly Trp Val Gln Tyr 
145                 150                 155                 160 


Leu Ser Asp Gly Asp Asp Ile Cys Glu His Pro Phe Gln Glu Leu Tyr 
                165                 170                 175     


Thr Ile Gln Gly Asn Ser Gln Gly Arg Pro Cys Val Phe Pro Phe Arg 
            180                 185                 190         


Tyr Asn Asn Gln Trp Phe Tyr Glu Cys Thr Lys Glu Gly Arg Lys Asp 
        195                 200                 205             


Gly Leu Leu Trp Cys Ala Thr Thr Ser Gln Tyr Glu Lys Asp Gln Thr 
    210                 215                 220                 


Trp Gly Phe Cys Pro Asn Pro Gly Arg Tyr Glu Ile Gly Cys Lys Val 
225                 230                 235                 240 


Phe Trp Glu Lys Asp Pro Asp Thr Asn Ile Cys Tyr Gln Phe Asn Leu 
                245                 250                 255     


Asn Ser Phe Leu Ser Trp Asn Glu Ala Arg Ser Ser Cys Lys Met Gln 
            260                 265                 270         


Gly Gly Asp Leu Leu Ser Ile Thr His Trp Lys Glu Glu Asn Phe Ile 
        275                 280                 285             


Gln Lys Phe Leu Ser Val Lys Glu Val Lys Lys Val Trp Ile Gly Leu 
    290                 295                 300                 


Asn Gln Leu Asp Glu Val Asn Gly Trp Gln Trp Ser Asp Gly Thr Pro 
305                 310                 315                 320 


Leu Ile His Leu Asn Trp Asp Pro Asp Val Asn Phe Asp Pro Phe Val 
                325                 330                 335     


Gln Tyr His Cys Gly Thr Phe Asn Ser Leu Leu Trp Asp Ser Trp Gln 
            340                 345                 350         


Asn His Asp Cys Glu Ser Pro Leu Pro Tyr Val Cys Lys Lys His Leu 
        355                 360                 365             


Asn His Thr Lys Arg Glu Leu Leu Ala Glu Lys Asn Thr Trp Lys Tyr 
    370                 375                 380                 


Tyr Pro Thr His Cys Glu Pro Ser Trp His Pro Tyr Asn Gly Asn Cys 
385                 390                 395                 400 


Tyr Arg Leu Gln Lys Glu Glu Lys Asn Trp Thr Ala Ala Leu His Ser 
                405                 410                 415     


Cys Gln Ser Ile Lys Ser Lys Leu Ile Asn Met Ala Ser Leu Ala Glu 
            420                 425                 430         


Val Glu Phe Leu Val Asn Leu Leu Lys Asp Glu Asn Val Ser Glu Thr 
        435                 440                 445             


Trp Ile Gly Leu Ser Ser Gly Arg Asn Pro Val Phe Phe Asp Trp Ser 
    450                 455                 460                 


Gly Gly Ser Ser Ala Thr Phe Thr Leu Trp His Lys Gln Gln Pro Asn 
465                 470                 475                 480 


Thr Phe Pro Asn Gly Ser Arg Leu Cys Val Ser Ala Asp Lys Thr Gly 
                485                 490                 495     


Gly His Trp Lys Val Arg Asn Cys Glu Glu Thr Leu Phe Tyr Ile Cys 
            500                 505                 510         


Lys Asn Ala Gly Lys Val Leu Ser Glu Ala Lys Ser Gly Cys Gln Glu 
        515                 520                 525             


Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys Ile Asp Leu Ile Arg 
    530                 535                 540                 


Arg Ser Phe Asp Gln Ala Ser Arg Gly Tyr Tyr Cys Pro Pro Ser Leu 
545                 550                 555                 560 


Val Thr Val Thr Asn Arg Phe Glu Gln Ala Phe Ile Thr Asn Met Ile 
                565                 570                 575     


Ser Ser Val Val Lys Thr Glu Asp Ser Tyr Phe Trp Ile Ala Leu Gln 
            580                 585                 590         


Asp Gln Asn Val Thr Gly Glu Tyr Thr Trp Lys Val Arg Gly Gln Glu 
        595                 600                 605             


Tyr Gln Pro Val Gln Tyr Thr Asn Trp Asn Lys Tyr Gln Pro Arg Tyr 
    610                 615                 620                 


Asn Gly Gly Cys Val Val Met Arg Gly Gly Asn Pro Pro Gly Leu Trp 
625                 630                 635                 640 


Glu Val Lys Asp Cys Gln Arg Phe Arg Ala Met Ser Leu Cys Lys Gln 
                645                 650                 655     


Pro Leu Asn Pro His Pro Glu Thr Gln Arg Glu Lys Ile Trp Pro Phe 
            660                 665                 670         


Glu Pro Cys Phe Leu Gly Trp Glu Ser Lys Pro Asn Leu Pro Ser Cys 
        675                 680                 685             


Tyr Lys Val Phe His Ser Glu Lys Val Leu Met Lys Arg Thr Trp Ser 
    690                 695                 700                 


Glu Ala Glu Ala Leu Cys Glu Asp Phe Gly Ala His Leu Ala Ser Phe 
705                 710                 715                 720 


Ser His Ile Asp Glu Glu Asp Phe Val Asn Glu Met Val Leu Ser Lys 
                725                 730                 735     


Phe Asn Arg Thr Glu Glu Arg Gln Phe Trp Ile Gly Phe Asn Lys Arg 
            740                 745                 750         


Asn Pro Leu Ser Gly Gly Ser Trp Glu Trp Ser Asp Gly Thr Pro Val 
        755                 760                 765             


Ile Ser Ser Phe Leu Asp Asp Met Tyr Ile Gly Glu Asp Ala Arg Asn 
    770                 775                 780                 


Cys Ala Ile Tyr Gln Thr Asn Lys Thr Val Leu Pro Leu Arg Cys Gly 
785                 790                 795                 800 


Ser Lys Arg Glu Trp Ile Cys Lys Leu Pro Lys Asp Val Arg Pro Met 
                805                 810                 815     


Ile Pro Lys Trp Tyr Gln Tyr Asp Gly Pro Trp Leu Phe His His Gly 
            820                 825                 830         


Thr Glu Tyr Leu Phe His Thr Ser Ala Thr Glu Trp Ala Asn Phe Glu 
        835                 840                 845             


Leu Val Cys Gln Leu Leu Asp Ser Asn Leu Leu Thr Ile His Ser Ala 
    850                 855                 860                 


Glu Glu Gln Glu Phe Val Gln Asn Lys Ile Lys Thr Leu Ser Lys Ser 
865                 870                 875                 880 


Asp Val Asn Trp Trp Met Gly Leu His Lys Met Gly Pro Asn Asp Gly 
                885                 890                 895     


Phe Cys Trp Lys Asp Gly Ser Pro Leu Ile Phe Gln Asn Trp Asp Lys 
            900                 905                 910         


Gly Arg Glu Arg Ser Gly Gln Asn Gln Arg Gln Arg Cys Gly Phe Ile 
        915                 920                 925             


Ser Ser Glu Thr Gly Leu Trp Gly Asp Asp Asp Cys Ser Val Ala Met 
    930                 935                 940                 


Pro Ser Ile Cys Lys Arg Lys Lys Ile Trp Ile Thr Glu Lys Asp Leu 
945                 950                 955                 960 


Ser Glu Gln Pro His Gly Leu Cys Pro Lys Gly Trp Leu Tyr Phe Gly 
                965                 970                 975     


Ser Lys Cys Phe Leu Val Glu Ile Pro Lys Asp Pro Ser Lys Leu Lys 
            980                 985                 990         


Ser Trp Lys Ser Ala Gln Asp Ser  Cys Ala Glu Glu Asp  Gly Val Leu 
        995                 1000                 1005             


Ala Ser  Ile Glu Asn Glu Val  Glu Gln Ala Phe Ile  Thr Met Asn 
    1010                 1015                 1020             


Leu Phe  Gly Gln Lys Ala Asn  Val Trp Ile Gly Leu  Gln Asn Ser 
    1025                 1030                 1035             


Asp Tyr  Glu Glu Trp Leu Asn  Gly Lys His Val Ala  Tyr Ser Asn 
    1040                 1045                 1050             


Trp Leu  Pro Val Asp Ile Ile  Asn Ser Gln Ser Leu  Asn Thr Thr 
    1055                 1060                 1065             


Lys Leu  Arg Glu Gln Val His  Leu Cys Ala Leu Leu  Ser Ser Asn 
    1070                 1075                 1080             


Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr Leu Glu  Asp Cys Gly 
    1085                 1090                 1095             


Lys Glu  Ser Tyr Gly Tyr Ile  Cys Glu Lys Met Gln  Asp Thr Ser 
    1100                 1105                 1110             


Lys His  Asn Thr Asn Ala Ser  Thr Met Tyr Pro Thr  Ser Ser Thr 
    1115                 1120                 1125             


Leu Gln  Tyr Gly Asn Arg Thr  Phe Lys Val Ile Gly  Gly Asn Met 
    1130                 1135                 1140             


Thr Trp  Tyr Met Ala Leu Asp  Ile Cys Ala Ala Asn  Gly Ala Glu 
    1145                 1150                 1155             


Leu Val  Ser Ile Thr Asp Gln  Phe Arg Gln Ser Phe  Leu Thr Val 
    1160                 1165                 1170             


Leu Val  Asn Gln Leu Gly His  Ala His Trp Ile Gly  Leu Phe Thr 
    1175                 1180                 1185             


Ser Asp  Asn Gly Leu Asn Phe  Glu Trp Ser Asp Gly  Thr Lys Ser 
    1190                 1195                 1200             


Ser Phe  Ala Tyr Trp Glu Asp  Glu Ser Pro Ser Leu  Gly Gly Cys 
    1205                 1210                 1215             


Thr Leu  Val Asp Ile Asn Gly  Gly Trp Lys Ser Ala  Asp Cys Glu 
    1220                 1225                 1230             


Thr Leu  Leu Gln Gly Ala Val  Cys His Val Pro Thr  Glu Thr Ser 
    1235                 1240                 1245             


Leu Ser  Glu Phe Lys Gly Leu  Cys Ser Glu Thr Ser  Phe Pro Trp 
    1250                 1255                 1260             


Val Lys  Leu Lys Asn Asn Cys  Tyr Ser Phe Ser Thr  Val Leu Gln 
    1265                 1270                 1275             


Ser Met  Ser Phe Asp Ala Ala  Gln Lys Phe Cys Lys  Gly Gln Gly 
    1280                 1285                 1290             


Ser Asn  Leu Leu Thr Ile Lys  Glu Glu Val Glu Asn  Ser Phe Leu 
    1295                 1300                 1305             


Leu Glu  Glu Leu His Ala Tyr  His Ser Ser Val Pro  Met Val Trp 
    1310                 1315                 1320             


Leu Asn  Ala Gln Phe Asp Ser  Asn Asn Gly Thr Ile  Thr Trp Phe 
    1325                 1330                 1335             


Asp Gly  Ser Pro Ala Glu Leu  Ser Asn Trp Gly Ile  Arg Glu Pro 
    1340                 1345                 1350             


Asp Leu  Asp Arg Phe Lys Thr  Gln Leu Cys Ile Ala  Met Asn Thr 
    1355                 1360                 1365             


Lys Asp  Ala Val Trp Gln Leu  Cys Pro Cys Thr Glu  Lys Lys Gly 
    1370                 1375                 1380             


Phe Ile  Cys Lys Met Glu Thr  Asp Ala Asn Asp Leu  Asn Ile Trp 
    1385                 1390                 1395             


Ala Gly  Lys Ala Pro Ser His  Gly Phe Ile Pro Leu  Ala Val Thr 
    1400                 1405                 1410             


Val Thr  Leu Ile Val Ile Leu  Gly Phe Ser Thr Phe  Ser Phe Cys 
    1415                 1420                 1425             


Leu Tyr  Lys Leu Asn Ser Arg  Leu Phe Arg Arg Phe  Ser Ala Phe 
    1430                 1435                 1440             


Arg Ile  Thr Tyr Tyr Thr Ser  Thr Asn Ser Gly Ile  Ala Pro Leu 
    1445                 1450                 1455             


Glu Glu  Asn Ile Leu Ile Ser  Asp Leu Glu Arg Tyr  Asp 
    1460                 1465                 1470     


<210>  157
<211>  752
<212>  PRT
<213>  Rattus norvegicus

<400>  157

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Ala Asp Tyr 
            20                  25                  30          


Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Ala Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Val Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Thr 
545                 550                 555                 560 


Pro Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  158
<211>  752
<212>  PRT
<213>  Rattus norvegicus

<400>  158

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Ala Asp Tyr 
            20                  25                  30          


Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Ala Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Val Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Thr 
545                 550                 555                 560 


Pro Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  159
<211>  776
<212>  PRT
<213>  Rattus norvegicus

<400>  159

Met Ser Ile Asn Leu Thr Leu Asp Ile Tyr Ile Tyr Phe Leu Asn Asn 
1               5                   10                  15      


Ala Arg Ser Phe Cys Gly Lys Gln Arg Ser Lys Gln Leu Asn Phe Leu 
            20                  25                  30          


Cys Ser Lys Gln Tyr Trp Arg Met Asn His Val Asn Val His Arg Glu 
        35                  40                  45              


Phe His Thr Ser Lys Lys Ser Cys Lys Trp Asn Arg Ser Glu Ala His 
    50                  55                  60                  


Cys Ser Lys His Trp His Ser Ser Ser Asn His Gly Val His Ile Gly 
65                  70                  75                  80  


Ile Val Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys Val Ser 
                85                  90                  95      


Ile His Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala 
            100                 105                 110         


Ile Phe Gly Ser Gln Asn Glu Met Val Ser Arg Leu Ala Gln Phe Lys 
        115                 120                 125             


Pro Ser Ser Arg Ile Phe Arg Lys Val Ser Asp Arg Gly Trp Leu Lys 
    130                 135                 140                 


His Lys Asn Val Lys Gln Ala Ile Glu Ser Leu Lys Asn Tyr Ser Asp 
145                 150                 155                 160 


Lys Ser Ala Glu Lys Asn Ser Phe Ala Glu Gln Lys Ser Tyr Phe Ala 
                165                 170                 175     


Asp Lys Glu Glu Gly Ser Asp Lys His Ser Leu Tyr His Tyr Ala Tyr 
            180                 185                 190         


Arg Ile Thr Thr Arg Phe Gly Glu Ser Phe Tyr Phe Leu Ala Asn His 
        195                 200                 205             


Ile Asn Ser Tyr Phe Lys Asn Lys Glu Lys Met Ser Gln Ile Lys Glu 
    210                 215                 220                 


Asp Arg Gln Leu Gln Asp Lys Pro Cys Leu Glu Glu Ser Lys Ser Ile 
225                 230                 235                 240 


Ser Pro Ser Pro Asp Ile Leu Thr Asp Arg Pro Asp Ser Gly Pro Pro 
                245                 250                 255     


Leu Asn Val Glu Asp Lys Leu Ser Ser Ser Thr Gln Leu Pro Glu Ala 
            260                 265                 270         


Leu Pro Val Ser Thr Lys Gln Ser Ile Ala Asn Phe Leu Ser Arg Pro 
        275                 280                 285             


Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly Leu Val 
    290                 295                 300                 


Pro Lys Leu Lys Ser Asp Pro Lys Ser Gln Pro Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Pro Ser Lys Thr Asp Glu Pro Ile Cys Lys Asp Lys Lys Ala Glu Glu 
                325                 330                 335     


Lys Lys Arg Val Leu Leu Gln Arg Glu Lys Ile Ile Ala Arg Val Ser 
            340                 345                 350         


Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg Thr Thr 
        355                 360                 365             


Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe His Leu 
    370                 375                 380                 


Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu Lys Ile Ile 
385                 390                 395                 400 


Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys Asp Glu Thr Leu Gln Ala 
                405                 410                 415     


Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro Val Lys 
            420                 425                 430         


Gly Arg Gly Ile Arg Ile Leu Ala Ile Asp Gly Gly Gly Thr Arg Gly 
        435                 440                 445             


Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr Gln Lys 
    450                 455                 460                 


Pro Ile His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr Gly Ala 
465                 470                 475                 480 


Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp Glu Cys 
                485                 490                 495     


Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Thr Gln Asn Val 
            500                 505                 510         


Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr Asp Ser 
        515                 520                 525             


His Thr Trp Glu Lys Ile Leu Lys Asp Lys Val Gly Ser Ala Leu Met 
    530                 535                 540                 


Ile Glu Thr Ala Arg Asp Pro Leu Cys Pro Lys Val Ala Ala Val Ser 
545                 550                 555                 560 


Thr Ile Val Asn Arg Gly Gln Thr Pro Lys Ala Phe Val Phe Arg Asn 
                565                 570                 575     


Tyr Gly His Phe Pro Gly Thr Asn Ser His Tyr Leu Gly Gly Cys Gln 
            580                 585                 590         


Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro Gly Tyr 
        595                 600                 605             


Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp Gly Gly Leu 
    610                 615                 620                 


Leu Leu Asn Asn Pro Ser Ala Leu Ala Leu His Glu Cys Lys Cys Ile 
625                 630                 635                 640 


Trp Pro Asp Thr Pro Leu Glu Cys Ile Val Ser Leu Gly Thr Gly Arg 
                645                 650                 655     


Tyr Glu Ser Asp Val Arg Asn Thr Thr Thr Tyr Thr Ser Leu Lys Thr 
            660                 665                 670         


Lys Leu Ser Asn Val Ile Ser Ser Ala Thr Asp Thr Glu Glu Val His 
        675                 680                 685             


Ile Met Leu Asp Gly Leu Leu Pro Ala Asp Thr Tyr Phe Arg Phe Asn 
    690                 695                 700                 


Pro Val Ile Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asn Glu Lys 
705                 710                 715                 720 


Leu Asp Gln Leu Gln Leu Glu Gly Met Lys Tyr Leu Glu Arg Asn Asp 
                725                 730                 735     


Glu Lys Met Lys Lys Leu Ala Lys Ile Leu Ser Arg Glu Lys Thr Thr 
            740                 745                 750         


Leu Gln Lys Ile Ser Asp Trp Ile Lys Leu Lys Ser Asp Met Tyr Glu 
        755                 760                 765             


Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775     


<210>  160
<211>  1522
<212>  PRT
<213>  Mus musculus

<400>  160

Met Ala Trp Ser Ser Arg Arg Val Val Ala Ser Leu Ala Ser Cys Ser 
1               5                   10                  15      


Leu Val Gln Ser Arg Gly His Gly Ser Asp Ser Arg Gly Cys His Leu 
            20                  25                  30          


Ala Cys Leu Met Val Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu 
        35                  40                  45              


Gln Gln Leu Leu Leu Leu Gly Ile His Gln Gly Ile Ala Gln Asp Leu 
    50                  55                  60                  


Thr His Ile Gln Glu Pro Ser Leu Glu Trp Arg Asp Lys Gly Ile Phe 
65                  70                  75                  80  


Ile Ile Gln Ser Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser 
                85                  90                  95      


Val Leu Thr Leu Glu Asn Cys Lys Gln Pro Asn Glu His Met Leu Trp 
            100                 105                 110         


Lys Trp Val Ser Asp Asp His Leu Phe Asn Val Gly Gly Ser Gly Cys 
        115                 120                 125             


Leu Gly Leu Asn Ile Ser Ala Leu Glu Gln Pro Leu Lys Leu Tyr Glu 
    130                 135                 140                 


Cys Asp Ser Thr Leu Ile Ser Leu Arg Trp His Cys Asp Arg Lys Met 
145                 150                 155                 160 


Ile Glu Gly Pro Leu Gln Tyr Lys Val Gln Val Lys Ser Asp Asn Thr 
                165                 170                 175     


Val Val Ala Arg Lys Gln Ile His Arg Trp Ile Ala Tyr Thr Ser Ser 
            180                 185                 190         


Gly Gly Asp Ile Cys Glu His Pro Ser Arg Asp Leu Tyr Thr Leu Lys 
        195                 200                 205             


Gly Asn Ala His Gly Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly 
    210                 215                 220                 


His Trp His His Asp Cys Ile Arg Glu Gly Gln Lys Glu His Leu Leu 
225                 230                 235                 240 


Trp Cys Ala Thr Thr Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe 
                245                 250                 255     


Cys Pro Asp Pro Thr Ser Met Lys Val Phe Cys Asp Ala Thr Trp Gln 
            260                 265                 270         


Arg Asn Gly Ser Ser Arg Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser 
        275                 280                 285             


Leu Ser Trp Asn Gln Ala His Ser Ser Cys Leu Met Gln Gly Gly Ala 
    290                 295                 300                 


Leu Leu Ser Ile Ala Asp Glu Asp Glu Glu Asp Phe Ile Arg Lys His 
305                 310                 315                 320 


Leu Ser Lys Val Val Lys Glu Val Trp Ile Gly Leu Asn Gln Leu Asp 
                325                 330                 335     


Glu Lys Ala Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu 
            340                 345                 350         


Asn Trp Ser Gln Glu Ile Thr Pro Gly Pro Phe Val Glu His His Cys 
        355                 360                 365             


Gly Thr Leu Glu Val Val Ser Ala Ala Trp Arg Ser Arg Asp Cys Glu 
    370                 375                 380                 


Ser Thr Leu Pro Tyr Ile Cys Lys Arg Asp Leu Asn His Thr Ala Gln 
385                 390                 395                 400 


Gly Ile Leu Glu Lys Asp Ser Trp Lys Tyr His Ala Thr His Cys Asp 
                405                 410                 415     


Pro Asp Trp Thr Pro Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Asp 
            420                 425                 430         


Arg Lys Ser Trp Leu Gly Ala Leu His Ser Cys Gln Ser Asn Asp Ser 
        435                 440                 445             


Val Leu Met Asp Val Ala Ser Leu Ala Glu Val Glu Phe Leu Val Ser 
    450                 455                 460                 


Leu Leu Arg Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser 
465                 470                 475                 480 


Asn Lys Ile Pro Val Ser Phe Glu Trp Ser Ser Gly Ser Ser Val Ile 
                485                 490                 495     


Phe Thr Asn Trp Tyr Pro Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg 
            500                 505                 510         


Gln Leu Cys Val Ser Ala Glu Glu Ser Asp Gly Arg Trp Lys Val Lys 
        515                 520                 525             


Asp Cys Lys Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly Gln Val 
    530                 535                 540                 


Pro Ala Asp Glu Gln Ser Gly Cys Pro Ala Gly Trp Glu Arg His Ser 
545                 550                 555                 560 


Arg Phe Cys Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Glu Glu Ala 
                565                 570                 575     


Ser Ser Gly Tyr Tyr Cys Ser Pro Ala Leu Leu Thr Ile Thr Ser Arg 
            580                 585                 590         


Phe Glu Gln Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Ala Glu Lys 
        595                 600                 605             


Asp Ser Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu 
    610                 615                 620                 


Tyr Thr Trp Lys Thr Val Gly Gln Arg Glu Pro Val Gln Tyr Thr Tyr 
625                 630                 635                 640 


Trp Asn Thr Arg Gln Pro Ser Asn Arg Gly Gly Cys Val Val Val Arg 
                645                 650                 655     


Gly Gly Ser Ser Leu Gly Arg Trp Glu Val Lys Asp Cys Ser Asp Phe 
            660                 665                 670         


Lys Ala Met Ser Leu Cys Lys Thr Pro Val Lys Ile Trp Glu Lys Thr 
        675                 680                 685             


Glu Leu Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu 
    690                 695                 700                 


Ser Ala Thr Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys 
705                 710                 715                 720 


Val Leu Met Lys Arg Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu 
                725                 730                 735     


Phe Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe 
            740                 745                 750         


Val Asn Glu Leu Leu His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln 
        755                 760                 765             


Phe Trp Ile Gly Phe Asn Arg Arg Asn Pro Leu Asn Ala Gly Ser Trp 
    770                 775                 780                 


Ala Trp Ser Asp Gly Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala 
785                 790                 795                 800 


Tyr Phe Glu Glu Asp Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Lys 
                805                 810                 815     


Thr Leu Leu Pro Ser Asn Cys Ala Ser Lys His Glu Trp Ile Cys Arg 
            820                 825                 830         


Ile Pro Arg Asp Val Arg Pro Lys Phe Pro Asp Trp Tyr Gln Tyr Asp 
        835                 840                 845             


Ala Pro Trp Leu Phe Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His 
    850                 855                 860                 


Pro Ala Glu Trp Ala Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser 
865                 870                 875                 880 


Asp Phe Leu Thr Ile Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser 
                885                 890                 895     


Lys Ile Lys Gly Leu Thr Lys Tyr Gly Val Lys Trp Trp Ile Gly Leu 
            900                 905                 910         


Glu Glu Gly Gly Ala Arg Asp Gln Ile Gln Trp Ser Asn Gly Ser Pro 
        915                 920                 925             


Val Ile Phe Gln Asn Trp Asp Lys Gly Arg Glu Glu Arg Val Asp Ser 
    930                 935                 940                 


Gln Arg Lys Arg Cys Val Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly 
945                 950                 955                 960 


Thr Glu Asn Cys Ser Val Pro Leu Pro Ser Ile Cys Lys Arg Val Lys 
                965                 970                 975     


Ile Trp Val Ile Glu Lys Glu Lys Pro Pro Thr Gln Pro Gly Thr Cys 
            980                 985                 990         


Pro Lys Gly Trp Leu Tyr Phe Asn  Tyr Lys Cys Phe Leu  Val Thr Ile 
        995                 1000                 1005             


Pro Lys  Asp Pro Arg Glu Leu  Lys Thr Trp Thr Gly  Ala Gln Glu 
    1010                 1015                 1020             


Phe Cys  Val Ala Lys Gly Gly  Thr Leu Val Ser Ile  Lys Ser Glu 
    1025                 1030                 1035             


Leu Glu  Gln Ala Phe Ile Thr  Met Asn Leu Phe Gly  Gln Thr Thr 
    1040                 1045                 1050             


Asn Val  Trp Ile Gly Leu Gln  Ser Thr Asn His Glu  Lys Trp Val 
    1055                 1060                 1065             


Asn Gly  Lys Pro Leu Val Tyr  Ser Asn Trp Ser Pro  Ser Asp Ile 
    1070                 1075                 1080             


Ile Asn  Ile Pro Ser Tyr Asn  Thr Thr Glu Phe Gln  Lys His Ile 
    1085                 1090                 1095             


Pro Leu  Cys Ala Leu Met Ser  Ser Asn Pro Asn Phe  His Phe Thr 
    1100                 1105                 1110             


Gly Lys  Trp Tyr Phe Asp Asp  Cys Gly Lys Glu Gly  Tyr Gly Phe 
    1115                 1120                 1125             


Val Cys  Glu Lys Met Gln Asp  Thr Leu Glu His His  Val Asn Val 
    1130                 1135                 1140             


Ser Asp  Thr Ser Ala Ile Pro  Ser Thr Leu Glu Tyr  Gly Asn Arg 
    1145                 1150                 1155             


Thr Tyr  Lys Ile Ile Arg Gly  Asn Met Thr Trp Tyr  Ala Ala Gly 
    1160                 1165                 1170             


Lys Ser  Cys Arg Met His Arg  Ala Glu Leu Ala Ser  Ile Pro Asp 
    1175                 1180                 1185             


Ala Phe  His Gln Ala Phe Leu  Thr Val Leu Leu Ser  Arg Leu Gly 
    1190                 1195                 1200             


His Thr  His Trp Ile Gly Leu  Ser Thr Thr Asp Asn  Gly Gln Thr 
    1205                 1210                 1215             


Phe Asp  Trp Ser Asp Gly Thr  Lys Ser Pro Phe Thr  Tyr Trp Lys 
    1220                 1225                 1230             


Asp Glu  Glu Ser Ala Phe Leu  Gly Asp Cys Ala Phe  Ala Asp Thr 
    1235                 1240                 1245             


Asn Gly  Arg Trp His Ser Thr  Ala Cys Glu Ser Phe  Leu Gln Gly 
    1250                 1255                 1260             


Ala Ile  Cys His Val Val Thr  Glu Thr Lys Ala Phe  Glu His Pro 
    1265                 1270                 1275             


Gly Leu  Cys Ser Glu Thr Ser  Val Pro Trp Ile Lys  Phe Lys Gly 
    1280                 1285                 1290             


Asn Cys  Tyr Ser Phe Ser Thr  Val Leu Asp Ser Arg  Ser Phe Glu 
    1295                 1300                 1305             


Asp Ala  His Glu Phe Cys Lys  Ser Glu Gly Ser Asn  Leu Leu Ala 
    1310                 1315                 1320             


Ile Arg  Asp Ala Ala Glu Asn  Ser Phe Leu Leu Glu  Glu Leu Leu 
    1325                 1330                 1335             


Ala Phe  Gly Ser Ser Val Gln  Met Val Trp Leu Asn  Ala Gln Phe 
    1340                 1345                 1350             


Asp Asn  Asn Asn Lys Thr Leu  Arg Trp Phe Asp Gly  Thr Pro Thr 
    1355                 1360                 1365             


Glu Gln  Ser Asn Trp Gly Leu  Arg Lys Pro Asp Met  Asp His Leu 
    1370                 1375                 1380             


Lys Pro  His Pro Cys Val Val  Leu Arg Ile Pro Glu  Gly Ile Trp 
    1385                 1390                 1395             


His Phe  Thr Pro Cys Glu Asp  Lys Lys Gly Phe Ile  Cys Lys Met 
    1400                 1405                 1410             


Glu Ala  Gly Ile Pro Ala Val  Thr Ala Gln Pro Glu  Lys Gly Leu 
    1415                 1420                 1425             


Ser His  Ser Ile Val Pro Val  Thr Val Thr Leu Thr  Leu Ile Ile 
    1430                 1435                 1440             


Ala Leu  Gly Ile Phe Met Leu  Cys Phe Trp Ile Tyr  Lys Gln Lys 
    1445                 1450                 1455             


Ser Asp  Ile Phe Gln Arg Leu  Thr Gly Ser Arg Gly  Ser Tyr Tyr 
    1460                 1465                 1470             


Pro Thr  Leu Asn Phe Ser Thr  Ala His Leu Glu Glu  Asn Ile Leu 
    1475                 1480                 1485             


Ile Ser  Asp Leu Glu Lys Asn  Thr Asn Asp Glu Glu  Val Arg Asp 
    1490                 1495                 1500             


Ala Pro  Ala Thr Glu Ser Lys  Arg Gly His Lys Gly  Arg Pro Ile 
    1505                 1510                 1515             


Cys Ile  Ser Pro 
    1520         


<210>  161
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  161

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  162
<211>  795
<212>  PRT
<213>  Mus musculus

<400>  162

Arg Pro Phe Pro Lys Pro Pro Gly Ala Pro Val Leu Asn Val Val Thr 
1               5                   10                  15      


Trp Thr Leu Leu Arg Thr Gly Leu Val Ser Ala Thr Leu Arg His Arg 
            20                  25                  30          


Gly Arg Leu Gly Leu Ser Ala Ala Pro Gln Arg Met Gln Phe Phe Gly 
        35                  40                  45              


Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn Leu Phe Ser Asn Pro 
    50                  55                  60                  


Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr Val Ser Ser Glu Arg 
65                  70                  75                  80  


Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln Asn Val Ser Asn Arg 
                85                  90                  95      


Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn Pro Gln Ser Gly Phe 
            100                 105                 110         


Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala Leu Val Asn Phe Gln 
        115                 120                 125             


Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu Ser Ser Val Gln Val 
    130                 135                 140                 


Leu His Val Glu Val Leu Gln His Leu Thr Asp Leu Ile Arg Asn His 
145                 150                 155                 160 


Pro Ser Trp Thr Val Thr His Leu Ala Val Glu Leu Gly Ile Arg Glu 
                165                 170                 175     


Cys Phe His His Ser Arg Ile Ile Ser Cys Ala Asn Ser Thr Glu Asn 
            180                 185                 190         


Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys Gly Asp Ser 
        195                 200                 205             


Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Ala Gln Met Asp Val 
    210                 215                 220                 


Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr Ala Val Gln Gly Asp 
225                 230                 235                 240 


Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn Ala Ser Ala Gly Leu 
                245                 250                 255     


Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu His Leu Ala Cys Lys 
            260                 265                 270         


Met Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys Asn Ala Arg 
        275                 280                 285             


Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile His Thr Ala Met Lys 
    290                 295                 300                 


Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser Met Asp Ser Asn 
305                 310                 315                 320 


Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu His Trp 
                325                 330                 335     


Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys Arg Gly Cys Asp 
            340                 345                 350         


Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala Leu His Val Ala Val 
        355                 360                 365             


Met Arg Asn Arg Phe Asp Cys Val Met Val Leu Leu Thr Tyr Gly Ala 
    370                 375                 380                 


Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr Pro Leu His Leu Ala 
385                 390                 395                 400 


Met Ser Lys Asp Asn Met Glu Met Val Lys Ala Leu Ile Val Phe Gly 
                405                 410                 415     


Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro Ala Leu Ile 
            420                 425                 430         


Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu Met Pro Ile Ser Arg 
        435                 440                 445             


Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met Arg Asp Glu Lys Arg 
    450                 455                 460                 


Ser His Asp His Leu Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu 
465                 470                 475                 480 


Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala 
                485                 490                 495     


Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile 
            500                 505                 510         


Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly 
        515                 520                 525             


Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr 
    530                 535                 540                 


Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His 
545                 550                 555                 560 


Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr 
                565                 570                 575     


Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp 
            580                 585                 590         


Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn Gln Asn Ile Asn Leu 
        595                 600                 605             


Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val Trp Arg Ala Ala Arg 
    610                 615                 620                 


Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu 
625                 630                 635                 640 


Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu 
                645                 650                 655     


Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys Gly Gln Gly Asn Lys 
            660                 665                 670         


Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr Gly Lys Ser Pro 
        675                 680                 685             


Gln Val Pro Val Thr Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp 
    690                 695                 700                 


Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val 
705                 710                 715                 720 


Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg 
                725                 730                 735     


Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln 
            740                 745                 750         


Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser Asp Ala Val Leu Val 
        755                 760                 765             


Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu 
    770                 775                 780                 


Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
785                 790                 795 


<210>  163
<211>  832
<212>  PRT
<213>  Mus musculus

<400>  163

Pro Gly Ser Trp Arg Leu Gly Ala Cys Asp Pro Glu Gln Arg Gly Arg 
1               5                   10                  15      


Leu Gly Leu Ser Ala Ala Pro Gln Arg Met Gln Phe Phe Gly Arg Leu 
            20                  25                  30          


Val Asn Thr Leu Ser Ser Val Thr Asn Leu Phe Ser Asn Pro Phe Arg 
        35                  40                  45              


Val Lys Glu Val Ser Leu Thr Asp Tyr Val Ser Ser Glu Arg Val Arg 
    50                  55                  60                  


Glu Glu Gly Gln Leu Ile Leu Leu Gln Asn Val Ser Asn Arg Thr Trp 
65                  70                  75                  80  


Asp Cys Val Leu Val Ser Pro Arg Asn Pro Gln Ser Gly Phe Arg Leu 
                85                  90                  95      


Phe Gln Leu Glu Ser Glu Ala Asp Ala Leu Val Asn Phe Gln Gln Phe 
            100                 105                 110         


Ser Ser Gln Leu Pro Pro Phe Tyr Glu Ser Ser Val Gln Val Leu His 
        115                 120                 125             


Val Glu Val Leu Gln His Leu Thr Asp Leu Ile Arg Asn His Pro Ser 
    130                 135                 140                 


Trp Thr Val Thr His Leu Ala Val Glu Leu Gly Ile Arg Glu Cys Phe 
145                 150                 155                 160 


His His Ser Arg Ile Ile Ser Cys Ala Asn Ser Thr Glu Asn Glu Glu 
                165                 170                 175     


Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys Gly Asp Ser Glu Ile 
            180                 185                 190         


Leu Val Glu Leu Val Gln Tyr Cys His Ala Gln Met Asp Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Glu Thr Ala Phe His Tyr Ala Val Gln Gly Asp Asn Pro 
    210                 215                 220                 


Gln Val Leu Gln Leu Leu Gly Lys Asn Ala Ser Ala Gly Leu Asn Gln 
225                 230                 235                 240 


Val Asn Asn Gln Gly Leu Thr Pro Leu His Leu Ala Cys Lys Met Gly 
                245                 250                 255     


Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys Asn Ala Arg Cys Asn 
            260                 265                 270         


Ile Met Gly Pro Gly Gly Phe Pro Ile His Thr Ala Met Lys Phe Ser 
        275                 280                 285             


Gln Lys Gly Cys Ala Glu Met Ile Ile Ser Met Asp Ser Asn Gln Ile 
    290                 295                 300                 


His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu His Trp Ala Lys 
305                 310                 315                 320 


Asn Ala Glu Met Ala Arg Met Leu Leu Lys Arg Gly Cys Asp Val Asp 
                325                 330                 335     


Ser Thr Ser Ser Ser Gly Asn Thr Ala Leu His Val Ala Val Met Arg 
            340                 345                 350         


Asn Arg Phe Asp Cys Val Met Val Leu Leu Thr Tyr Gly Ala Asn Ala 
        355                 360                 365             


Gly Ala Arg Gly Glu His Gly Asn Thr Pro Leu His Leu Ala Met Ser 
    370                 375                 380                 


Lys Asp Asn Met Glu Met Val Lys Ala Leu Ile Val Phe Gly Ala Glu 
385                 390                 395                 400 


Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro Ala Leu Ile Ala Ser 
                405                 410                 415     


Lys Ile Ser Lys Leu Ile Thr Arg Lys Ala Leu Leu Thr Leu Leu Lys 
            420                 425                 430         


Thr Val Gly Ala Asp His His Phe Pro Ile Ile Gln Gly Val Ser Thr 
        435                 440                 445             


Glu Gln Gly Ser Ala Ala Ala Thr His Pro Leu Phe Ser Leu Asp Arg 
    450                 455                 460                 


Thr Gln Pro Pro Ala Ile Ser Leu Asn Asn Leu Glu Leu Gln Asp Leu 
465                 470                 475                 480 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                485                 490                 495     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            500                 505                 510         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        515                 520                 525             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    530                 535                 540                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
545                 550                 555                 560 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                565                 570                 575     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            580                 585                 590         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        595                 600                 605             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    610                 615                 620                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
625                 630                 635                 640 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                645                 650                 655     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            660                 665                 670         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        675                 680                 685             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    690                 695                 700                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
705                 710                 715                 720 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                725                 730                 735     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            740                 745                 750         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        755                 760                 765             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    770                 775                 780                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
785                 790                 795                 800 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                805                 810                 815     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            820                 825                 830         


<210>  164
<211>  777
<212>  PRT
<213>  Mus musculus

<400>  164

Pro Gly Ser Trp Arg Leu Gly Ala Cys Asp Pro Glu Gln Arg Gly Arg 
1               5                   10                  15      


Leu Gly Leu Ser Ala Ala Pro Gln Arg Met Gln Phe Phe Gly Arg Leu 
            20                  25                  30          


Val Asn Thr Leu Ser Ser Val Thr Asn Leu Phe Ser Asn Pro Phe Arg 
        35                  40                  45              


Val Lys Glu Val Ser Leu Thr Asp Tyr Val Ser Ser Glu Arg Val Arg 
    50                  55                  60                  


Glu Glu Gly Gln Leu Ile Leu Leu Gln Asn Val Ser Asn Arg Thr Trp 
65                  70                  75                  80  


Asp Cys Val Leu Val Ser Pro Arg Asn Pro Gln Ser Gly Phe Arg Leu 
                85                  90                  95      


Phe Gln Leu Glu Ser Glu Ala Asp Ala Leu Val Asn Phe Gln Gln Phe 
            100                 105                 110         


Ser Ser Gln Leu Pro Pro Phe Tyr Glu Ser Ser Val Gln Val Leu His 
        115                 120                 125             


Val Glu Val Leu Gln His Leu Thr Asp Leu Ile Arg Asn His Pro Ser 
    130                 135                 140                 


Trp Thr Val Thr His Leu Ala Val Glu Leu Gly Ile Arg Glu Cys Phe 
145                 150                 155                 160 


His His Ser Arg Ile Ile Ser Cys Ala Asn Ser Thr Glu Asn Glu Glu 
                165                 170                 175     


Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys Gly Asp Ser Glu Ile 
            180                 185                 190         


Leu Val Glu Leu Val Gln Tyr Cys His Ala Gln Met Asp Val Thr Asp 
        195                 200                 205             


Asn Lys Gly Glu Thr Ala Phe His Tyr Ala Val Gln Gly Asp Asn Pro 
    210                 215                 220                 


Gln Val Leu Gln Leu Leu Gly Lys Asn Ala Ser Ala Gly Leu Asn Gln 
225                 230                 235                 240 


Val Asn Asn Gln Gly Leu Thr Pro Leu His Leu Ala Cys Lys Met Gly 
                245                 250                 255     


Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys Asn Ala Arg Cys Asn 
            260                 265                 270         


Ile Met Gly Pro Gly Gly Phe Pro Ile His Thr Ala Met Lys Phe Ser 
        275                 280                 285             


Gln Lys Gly Cys Ala Glu Met Ile Ile Ser Met Asp Ser Asn Gln Ile 
    290                 295                 300                 


His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu His Trp Ala Lys 
305                 310                 315                 320 


Asn Ala Glu Met Ala Arg Met Leu Leu Lys Arg Gly Cys Asp Val Asp 
                325                 330                 335     


Ser Thr Ser Ser Ser Gly Asn Thr Ala Leu His Val Ala Val Met Arg 
            340                 345                 350         


Asn Arg Phe Asp Cys Val Met Val Leu Leu Thr Tyr Gly Ala Asn Ala 
        355                 360                 365             


Gly Ala Arg Gly Glu His Gly Asn Thr Pro Leu His Leu Ala Met Ser 
    370                 375                 380                 


Lys Asp Asn Met Glu Met Val Lys Ala Leu Ile Val Phe Gly Ala Glu 
385                 390                 395                 400 


Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro Ala Leu Ile Ala Ser 
                405                 410                 415     


Lys Ile Ser Lys Gln Leu Gln Asp Leu Met Pro Ile Ser Arg Ala Arg 
            420                 425                 430         


Lys Pro Ala Phe Ile Leu Ser Ser Met Arg Asp Glu Lys Arg Ser His 
        435                 440                 445             


Asp His Leu Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val Ile 
    450                 455                 460                 


Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys 
465                 470                 475                 480 


Asp Leu Phe Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala 
                485                 490                 495     


Leu Ala Ile Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Val Tyr 
            500                 505                 510         


Phe Arg Met Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser 
        515                 520                 525             


Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys 
    530                 535                 540                 


Met Thr Asp Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser 
545                 550                 555                 560 


Asp Arg Gln Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro 
                565                 570                 575     


Glu Ala Val Arg Glu Pro Arg Cys Asn Gln Asn Ile Asn Leu Lys Pro 
            580                 585                 590         


Pro Thr Gln Pro Ala Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser 
        595                 600                 605             


Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly 
    610                 615                 620                 


Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His 
625                 630                 635                 640 


Glu Tyr Asn Gln Asp Met Ile Arg Lys Gly Gln Gly Asn Lys Val Lys 
                645                 650                 655     


Lys Leu Ser Ile Val Val Ser Leu Gly Thr Gly Lys Ser Pro Gln Val 
            660                 665                 670         


Pro Val Thr Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu 
        675                 680                 685             


Ala Lys Thr Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp 
    690                 695                 700                 


Cys Cys Thr Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp 
705                 710                 715                 720 


Cys Glu Met Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly 
                725                 730                 735     


Ser Asp Ile Met Leu Asp Glu Val Ser Asp Ala Val Leu Val Asn Ala 
            740                 745                 750         


Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln 
        755                 760                 765             


Lys Leu Val Gln Leu Leu Leu Ser Pro 
    770                 775         


<210>  165
<211>  775
<212>  PRT
<213>  Monodelphis domestica

<400>  165

Met Ser Ile His Leu Thr Leu Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Leu Leu 
            20                  25                  30          


Cys Thr Ser Lys Tyr Trp Arg Ile Ser Tyr Ile Asn Gln Gln Arg Ser 
        35                  40                  45              


Phe His Ile Ser Arg Thr Arg Tyr Lys Trp Thr Arg Ser His Thr Phe 
    50                  55                  60                  


Val Ser Ser Lys His Ser Cys Asn Pro Arg Asn His Asp Leu His Ile 
65                  70                  75                  80  


Gly Val Ser Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys Val 
                85                  90                  95      


Ser Ile His Met Ser Arg Ile Lys Asn Thr Leu Asp Ser Val Ser Lys 
            100                 105                 110         


Ala Val Phe Gly Asn Gln Asn Glu Met Phe Ser Arg Phe Ser Arg Phe 
        115                 120                 125             


Lys Pro Gly Ile Leu Arg Lys Lys Ser Glu Asp Asp Val Leu Lys Gln 
    130                 135                 140                 


Lys Ser Val Lys Gln Ala Ser Gly Thr Asn Thr Leu Asn Asp Ser Ser 
145                 150                 155                 160 


Asp Asn Lys Thr Glu Lys Gly Pro Phe Pro Glu Glu Lys Gly Leu Glu 
                165                 170                 175     


Glu Arg Lys Gln Asn Ile Tyr Tyr Thr Asn Tyr Ile Ile Ala Lys Phe 
            180                 185                 190         


Glu Glu Ser Leu Tyr Phe Leu Ser Asn His Ile Asn Ser Tyr Phe Thr 
        195                 200                 205             


Asn Met Thr Glu Arg Thr Glu Asn Asp His Leu Gln Gln Ala Thr Glu 
    210                 215                 220                 


Met Lys Met Gly Lys Asp Glu Ala Gly Ile Arg Glu Ser Pro Ser Lys 
225                 230                 235                 240 


Asp Glu Val Gln Leu Lys Glu Lys Gly Thr Asp Ser Gln Phe Leu Ser 
                245                 250                 255     


Pro Thr Val Ala His Ser Glu Glu Leu Thr Gly Thr Ser Asp Thr Leu 
            260                 265                 270         


Pro Val Ser Val Lys Gln Ser Phe Ala Asn Phe Leu Ala Arg Pro Ser 
        275                 280                 285             


Asp Ser Val Gln Ala Leu Val Gly Gly Tyr Ile Val Gly Leu Val Pro 
    290                 295                 300                 


Lys Leu Lys Ala Asp Ala Lys Tyr His Ser Glu Glu Phe Gln Gly Gly 
305                 310                 315                 320 


Lys Ala Glu Gln Ala Ser Gly Lys Glu Asn His Glu Glu Glu Lys Lys 
                325                 330                 335     


His Leu Ser Leu Gln Arg Glu Lys Ile Ile Glu Arg Val Ser Ile Asp 
            340                 345                 350         


Asn Arg Thr Arg Ala Leu Val Arg Ala Leu Arg Arg Thr Thr Asp His 
        355                 360                 365             


Lys Leu Cys Ile Asn Arg Ile Glu Glu Leu Thr Phe His Leu Leu Ala 
    370                 375                 380                 


Phe Pro Glu Ala Arg Ala Leu Ala Val Lys Glu Lys Leu Val Pro Tyr 
385                 390                 395                 400 


Leu Leu Arg Leu Arg Arg Asn Lys Asp Glu Ile Leu Gln Ala Thr Val 
                405                 410                 415     


Arg Glu Asn Leu Ala Leu Ile Gly Tyr Thr Asp Pro Val Lys Gly Arg 
            420                 425                 430         


Gly Ile Arg Ile Leu Thr Ile Asp Gly Gly Gly Ile Arg Gly Val Val 
        435                 440                 445             


Ala Leu Gln Ser Leu Arg Lys Ile Val Glu Leu Thr Lys Lys Pro Ile 
    450                 455                 460                 


His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr Gly Ala Ile Leu 
465                 470                 475                 480 


Ala Phe Met Val Gly Leu Phe His Met Asp Leu Asp Asp Cys Glu Glu 
                485                 490                 495     


Leu Tyr Arg Lys Leu Gly Thr Asp Val Phe Thr Gln Asn Leu Ile Ile 
            500                 505                 510         


Gly Thr Val Lys Met Gly Trp Lys His Glu Phe Tyr Asp Ser Glu Thr 
        515                 520                 525             


Trp Glu Arg Ile Leu Lys Asp Arg Leu Gly Ser Asn Leu Met Ile Glu 
    530                 535                 540                 


Thr Ala Arg Asn Pro Lys Cys Pro Lys Val Ala Ala Val Ser Thr Val 
545                 550                 555                 560 


Val Asn Arg Gly Ile Gln Pro Lys Ala Phe Val Phe Arg Asn Tyr Asp 
                565                 570                 575     


Leu Phe Pro Gly Ser Lys Ser His Tyr Leu Gly Gly Cys His His Lys 
            580                 585                 590         


Val Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro Gly Tyr Phe Ala 
        595                 600                 605             


Glu Tyr Thr Leu Gly Lys Asp Leu His Gln Asp Gly Gly Leu Leu Leu 
    610                 615                 620                 


Asn Asn Pro Thr Ala Leu Ala Met His Glu Cys Lys Cys Leu Trp Pro 
625                 630                 635                 640 


Asp Thr Pro Leu Gln Cys Ile Val Ser Leu Gly Thr Gly Arg Tyr Glu 
                645                 650                 655     


Gly Asp Val Arg Asn Tyr Ser Met Thr Ala Thr Ser Leu Arg Ser Lys 
            660                 665                 670         


Leu Ser Thr Val Ile Ser Ser Ala Thr Asp Thr Glu Glu Val His Ile 
        675                 680                 685             


Met Leu Asp Asp Phe Leu Pro Pro Asp Thr Tyr Phe Arg Ile Asn Pro 
    690                 695                 700                 


Val Met Arg Glu Asn Ile Pro Leu Asp Glu Ser Arg Asn Glu Lys Leu 
705                 710                 715                 720 


Asp Phe Leu Gln Ser Glu Ser Ile Lys Tyr Leu Glu Arg Asn Glu Glu 
                725                 730                 735     


Lys Ile Lys Lys Leu Thr Lys Ile Leu Thr Gln Glu Lys Thr Ala Leu 
            740                 745                 750         


Gln Lys Ile Asn Asp Trp Leu Lys Leu Lys Ser Asp Met Tyr Glu Gly 
        755                 760                 765             


Phe Pro Phe Leu Ser Lys Leu 
    770                 775 


<210>  166
<211>  782
<212>  PRT
<213>  Monodelphis domestica

<400>  166

Met Ser Ile His Leu Thr Leu Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Leu Leu 
            20                  25                  30          


Cys Thr Ser Lys Tyr Trp Arg Ile Ser Tyr Ile Asn Gln Gln Arg Ser 
        35                  40                  45              


Phe His Ile Ser Arg Thr Arg Tyr Lys Trp Thr Arg Ser His Thr Phe 
    50                  55                  60                  


Val Ser Ser Lys His Ser Cys Asn Pro Arg Asn His Asp Leu His Ile 
65                  70                  75                  80  


Gly Val Ser Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys Val 
                85                  90                  95      


Ser Ile His Met Ser Arg Ile Lys Asn Thr Leu Asp Ser Val Ser Lys 
            100                 105                 110         


Ala Val Phe Gly Asn Gln Asn Glu Met Phe Ser Arg Phe Ser Arg Phe 
        115                 120                 125             


Lys Pro Gly Ile Leu Arg Lys Lys Ser Glu Asp Asp Val Leu Lys Gln 
    130                 135                 140                 


Lys Ser Val Lys Gln Ala Ser Gly Thr Asn Thr Leu Asn Asp Ser Ser 
145                 150                 155                 160 


Asp Asn Lys Thr Glu Lys Gly Pro Phe Pro Glu Ala Lys Ile Asp Pro 
                165                 170                 175     


Val Leu Glu Lys Gly Leu Glu Glu Arg Lys Gln Asn Ile Tyr Tyr Thr 
            180                 185                 190         


Asn Tyr Ile Ile Ala Lys Phe Glu Glu Ser Leu Tyr Phe Leu Ser Asn 
        195                 200                 205             


His Ile Asn Ser Tyr Phe Thr Asn Met Thr Glu Arg Thr Glu Asn Asp 
    210                 215                 220                 


His Leu Gln Gln Ala Thr Glu Met Lys Met Gly Lys Asp Glu Ala Gly 
225                 230                 235                 240 


Ile Arg Glu Ser Pro Ser Lys Asp Glu Val Gln Leu Lys Glu Lys Gly 
                245                 250                 255     


Thr Asp Ser Gln Phe Leu Ser Pro Thr Val Ala His Ser Glu Glu Leu 
            260                 265                 270         


Thr Gly Thr Ser Asp Thr Leu Pro Val Ser Val Lys Gln Ser Phe Ala 
        275                 280                 285             


Asn Phe Leu Ala Arg Pro Ser Asp Ser Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Val Gly Leu Val Pro Lys Leu Lys Ala Asp Ala Lys Tyr His 
305                 310                 315                 320 


Ser Glu Glu Phe Gln Gly Gly Lys Ala Glu Gln Ala Ser Gly Lys Glu 
                325                 330                 335     


Asn His Glu Glu Glu Lys Lys His Leu Ser Leu Gln Arg Glu Lys Ile 
            340                 345                 350         


Ile Glu Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Arg Ala 
        355                 360                 365             


Leu Arg Arg Thr Thr Asp His Lys Leu Cys Ile Asn Arg Ile Glu Glu 
    370                 375                 380                 


Leu Thr Phe His Leu Leu Ala Phe Pro Glu Ala Arg Ala Leu Ala Val 
385                 390                 395                 400 


Lys Glu Lys Leu Val Pro Tyr Leu Leu Arg Leu Arg Arg Asn Lys Asp 
                405                 410                 415     


Glu Ile Leu Gln Ala Thr Val Arg Glu Asn Leu Ala Leu Ile Gly Tyr 
            420                 425                 430         


Thr Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Thr Ile Asp Gly 
        435                 440                 445             


Gly Gly Ile Arg Gly Val Val Ala Leu Gln Ser Leu Arg Lys Ile Val 
    450                 455                 460                 


Glu Leu Thr Lys Lys Pro Ile His Gln Leu Phe Asp Tyr Ile Cys Gly 
465                 470                 475                 480 


Val Ser Thr Gly Ala Ile Leu Ala Phe Met Val Gly Leu Phe His Met 
                485                 490                 495     


Asp Leu Asp Asp Cys Glu Glu Leu Tyr Arg Lys Leu Gly Thr Asp Val 
            500                 505                 510         


Phe Thr Gln Asn Leu Ile Ile Gly Thr Val Lys Met Gly Trp Lys His 
        515                 520                 525             


Glu Phe Tyr Asp Ser Glu Thr Trp Glu Arg Ile Leu Lys Asp Arg Leu 
    530                 535                 540                 


Gly Ser Asn Leu Met Ile Glu Thr Ala Arg Asn Pro Lys Cys Pro Lys 
545                 550                 555                 560 


Val Ala Ala Val Ser Thr Val Val Asn Arg Gly Ile Gln Pro Lys Ala 
                565                 570                 575     


Phe Val Phe Arg Asn Tyr Asp Leu Phe Pro Gly Ser Lys Ser His Tyr 
            580                 585                 590         


Leu Gly Gly Cys His His Lys Val Trp Gln Ala Ile Arg Ala Ser Ser 
        595                 600                 605             


Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Thr Leu Gly Lys Asp Leu His 
    610                 615                 620                 


Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Thr Ala Leu Ala Met His 
625                 630                 635                 640 


Glu Cys Lys Cys Leu Trp Pro Asp Thr Pro Leu Gln Cys Ile Val Ser 
                645                 650                 655     


Leu Gly Thr Gly Arg Tyr Glu Gly Asp Val Arg Asn Tyr Ser Met Thr 
            660                 665                 670         


Ala Thr Ser Leu Arg Ser Lys Leu Ser Thr Val Ile Ser Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Asp Phe Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Ile Asn Pro Val Met Arg Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Phe Leu Gln Ser Glu Ser Ile Lys 
                725                 730                 735     


Tyr Leu Glu Arg Asn Glu Glu Lys Ile Lys Lys Leu Thr Lys Ile Leu 
            740                 745                 750         


Thr Gln Glu Lys Thr Ala Leu Gln Lys Ile Asn Asp Trp Leu Lys Leu 
        755                 760                 765             


Lys Ser Asp Met Tyr Glu Gly Phe Pro Phe Leu Ser Lys Leu 
    770                 775                 780         


<210>  167
<211>  752
<212>  PRT
<213>  Bos taurus

<400>  167

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Val Asn Pro Phe Arg Val Lys Glu Val Ala Val Glu Asp Tyr 
            20                  25                  30          


His Ser Arg Arg Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Ser Ser Asn Arg Thr Trp Asp Cys Ile Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ala Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Thr Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Thr His Ile Leu Gln Ala Glu Val Leu Gln Gln Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Ser His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser His Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Asn Lys Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Thr Glu Val Leu Ser Glu Leu Val Gln His Cys Arg 
                165                 170                 175     


Ala Asn Met Asp Val Thr Asp Asn Ser Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Ser Ser Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Gly Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Tyr Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Val 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Leu Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asn Gly Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Phe Ile Ala Ser Arg Ile Ser Lys Gln Leu Gln Asp Ile 
385                 390                 395                 400 


Thr Gln Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Ile Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Glu Ala Pro Glu Cys Val Arg Glu Pro Arg Phe Ser 
545                 550                 555                 560 


Gln Asn Val Asn Leu Lys Pro Pro Thr His Pro Ser Glu Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Asp Ser Lys Val Lys Lys Leu Ser Val Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Arg Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Ile Asn 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Gln Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  168
<211>  805
<212>  PRT
<213>  Bos taurus

<400>  168

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Val Asn Pro Phe Arg Val Lys Glu Val Ala Val Glu Asp Tyr 
            20                  25                  30          


His Ser Arg Arg Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Ser Ser Asn Arg Thr Trp Asp Cys Ile Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ala Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Thr Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Thr His Ile Leu Gln Ala Glu Val Leu Gln Gln Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Ser His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser His Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Asn Lys Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Thr Glu Val Leu Ser Glu Leu Val Gln His Cys Arg 
                165                 170                 175     


Ala Asn Met Asp Val Thr Asp Asn Ser Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Ser Ser Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Gly Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Tyr Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Val 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Leu Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asn Gly Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Phe Ile Ala Ser Arg Ile Ser Lys Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Leu Leu Thr Leu Leu Arg Thr Val Gly Ala Asp Tyr Arg Phe Pro 
                405                 410                 415     


Leu Thr Gln Gly Phe Ser Thr Glu Gln Cys Ser Ala Ala Ala Pro Ser 
            420                 425                 430         


Phe Ser Met Glu Arg Ser His Pro Pro Pro Ile Ser Leu Asn Asn Leu 
        435                 440                 445             


Glu Leu Gln Asp Ile Thr Gln Ile Ser Arg Ala Arg Lys Pro Ala Phe 
    450                 455                 460                 


Ile Leu Ser Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu Leu 
465                 470                 475                 480 


Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu 
                485                 490                 495     


Ile Ala Ile Glu Lys Ala Ser Gly Ile Ala Thr Lys Asp Leu Phe Asp 
            500                 505                 510         


Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu 
        515                 520                 525             


His Ser Lys Ser Met Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys 
    530                 535                 540                 


Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu 
545                 550                 555                 560 


Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp Val 
                565                 570                 575     


Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro 
            580                 585                 590         


Ala Glu Leu His Leu Phe Arg Asn Tyr Glu Ala Pro Glu Cys Val Arg 
        595                 600                 605             


Glu Pro Arg Phe Ser Gln Asn Val Asn Leu Lys Pro Pro Thr His Pro 
    610                 615                 620                 


Ser Glu Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro 
625                 630                 635                 640 


Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala 
                645                 650                 655     


Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln 
            660                 665                 670         


Asp Leu Ile Arg Lys Gly Gln Asp Ser Lys Val Lys Lys Leu Ser Val 
        675                 680                 685             


Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys 
    690                 695                 700                 


Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val 
705                 710                 715                 720 


Phe Gly Ala Lys Glu Leu Gly Arg Met Val Val Asp Cys Cys Thr Asp 
                725                 730                 735     


Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val 
            740                 745                 750         


Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met 
        755                 760                 765             


Leu Asp Glu Ile Asn Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr 
    770                 775                 780                 


Glu Val Tyr Ile Tyr Glu His Arg Glu Gln Phe Gln Lys Leu Val Gln 
785                 790                 795                 800 


Leu Leu Leu Ser Pro 
                805 


<210>  169
<211>  784
<212>  PRT
<213>  Bos taurus

<400>  169

Met Ser Ile Asn Leu Thr Ile Asp Leu Tyr Tyr Ile Tyr Leu Leu Ser 
1               5                   10                  15      


Asn Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu Pro Phe 
            20                  25                  30          


Leu Cys Ser Pro Glu His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln 
        35                  40                  45              


Arg Gly Val His Met Ser Arg Ile Arg Cys Lys Trp Thr Lys Ser Glu 
    50                  55                  60                  


Ala His Ser Cys Ser Lys His Cys Ser Pro Leu Ser His His Gly Leu 
65                  70                  75                  80  


His Leu Ala Val Leu Arg Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr 
                85                  90                  95      


Lys Val Ser Pro Arg Met Ser Arg Ile Lys Asn Thr Leu Asn Ser Val 
            100                 105                 110         


Ser Lys Ala Val Phe Gly Lys Gln Asn Glu Met Ile Ser Arg Leu Ala 
        115                 120                 125             


Gln Leu Lys Pro Ser Ser Arg Ile Leu Arg Lys Val Thr Asp Ser Gly 
    130                 135                 140                 


Trp Leu Lys Gln Lys Ser Val Lys Gln Thr Ile Lys Phe Leu Lys Lys 
145                 150                 155                 160 


Tyr Ser Asp Lys Ser Ala Glu Lys Ser Ser Ile Pro Ala Lys Glu Ser 
                165                 170                 175     


Gln Val Ile Glu Lys Asp Asp Ile Gly Lys Pro Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Asn Ile Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Ser His Ile Asn Ser Tyr Phe Lys Arg Glu Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Asn Glu Asp Gln His Phe Gln Glu Lys Ser Glu Leu Glu Leu Lys Lys 
225                 230                 235                 240 


Val Glu Asp Glu Lys Pro Ser Ser Pro Asp Pro Gly Ile Leu Ser Asp 
                245                 250                 255     


Lys Lys Leu Asp Ser Glu Ala Ser Leu Tyr Ser Glu Asp Lys Pro Gly 
            260                 265                 270         


Ser Pro Ser Gly Thr Pro Glu Val Leu Pro Ile Ser Thr Lys Gln Ser 
        275                 280                 285             


Ile Ala Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val 
    290                 295                 300                 


Gly Gly Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys 
305                 310                 315                 320 


Ser Gln Leu Glu Asp Gln Glu Glu Ala Thr Lys Ala Glu Gln Ala Val 
                325                 330                 335     


Ser Lys Asp Lys Asn Ala Glu Glu Lys Arg Arg Leu Ser Leu Gln Arg 
            340                 345                 350         


Glu Lys Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu 
        355                 360                 365             


Val Gln Ala Leu Arg Arg Thr Thr Asp Pro Arg Leu Cys Ile Asn Arg 
    370                 375                 380                 


Val Glu Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly 
385                 390                 395                 400 


Val Ala Val Lys Glu Lys Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln 
                405                 410                 415     


Ile Lys Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu 
            420                 425                 430         


Ile Gly Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser 
        435                 440                 445             


Ile Asp Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg 
    450                 455                 460                 


Lys Leu Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr 
465                 470                 475                 480 


Ile Cys Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu 
                485                 490                 495     


Phe His Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly 
            500                 505                 510         


Ser Asp Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser 
        515                 520                 525             


Trp Ser His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys 
    530                 535                 540                 


Asp Arg Met Gly Ser Ser Leu Met Ile Glu Thr Ala Arg Asn Pro Lys 
545                 550                 555                 560 


Cys Pro Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr 
                565                 570                 575     


Pro Lys Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn 
            580                 585                 590         


Ser His Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg 
        595                 600                 605             


Ala Ser Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn 
    610                 615                 620                 


Asp Leu His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu 
625                 630                 635                 640 


Ala Met His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys 
                645                 650                 655     


Ile Val Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Asn 
            660                 665                 670         


Val Thr Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser 
        675                 680                 685             


Ala Thr Asp Thr Glu Glu Val His Val Met Leu Asp Gly Leu Leu Pro 
    690                 695                 700                 


Pro Asp Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro 
705                 710                 715                 720 


Leu Asp Glu Ser Arg Asn Glu Lys Leu Asn Gln Leu Gln Leu Glu Gly 
                725                 730                 735     


Leu Lys Tyr Ile Glu Arg Asn Glu Glu Lys Met Lys Lys Leu Ala Lys 
            740                 745                 750         


Ile Leu Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile 
        755                 760                 765             


Lys Leu Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780                 


<210>  170
<211>  1463
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  171
<211>  1463
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  172
<211>  1324
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Ser 
    1310                 1315                 1320             


Lys 
    


<210>  173
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  174
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  175
<211>  682
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala Val Phe 
1               5                   10                  15      


Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln Phe Lys Pro Ser 
            20                  25                  30          


Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp Leu Lys Gln Lys 
        35                  40                  45              


Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr Ser Asp Lys Ser 
    50                  55                  60                  


Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His Ile Ile Asp Lys 
65                  70                  75                  80  


Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr Thr Ser Ser Ile 
                85                  90                  95      


Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser Asn His Ile Asn 
            100                 105                 110         


Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln Lys Glu Asn Glu 
        115                 120                 125             


His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys Val Glu Glu Gly 
    130                 135                 140                 


Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr Lys Pro Gly Ser 
145                 150                 155                 160 


Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro Ser Ala Ile Pro 
                165                 170                 175     


Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala Asn Phe Leu Ser 
            180                 185                 190         


Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly 
        195                 200                 205             


Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln Ser Glu Glu Gln 
    210                 215                 220                 


Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys Asp Arg Asn Ala 
225                 230                 235                 240 


Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala Arg 
                245                 250                 255     


Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg 
            260                 265                 270         


Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe 
        275                 280                 285             


His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu Arg 
    290                 295                 300                 


Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys Asp Glu Thr Leu 
305                 310                 315                 320 


Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro 
                325                 330                 335     


Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp Gly Gly Gly Thr 
            340                 345                 350         


Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr 
        355                 360                 365             


Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr 
    370                 375                 380                 


Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp 
385                 390                 395                 400 


Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser Gln 
                405                 410                 415     


Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr 
            420                 425                 430         


Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg Met Gly Ser Ala 
        435                 440                 445             


Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val Ala Ala 
    450                 455                 460                 


Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe Val Phe 
465                 470                 475                 480 


Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His Tyr Leu Gly Gly 
                485                 490                 495     


Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro 
            500                 505                 510         


Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp Gly 
        515                 520                 525             


Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu Cys Lys 
    530                 535                 540                 


Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu Gly Thr 
545                 550                 555                 560 


Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr Tyr Thr Ser Leu 
                565                 570                 575     


Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr Glu Glu 
            580                 585                 590         


Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr Phe Arg 
        595                 600                 605             


Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asn 
    610                 615                 620                 


Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile Glu Arg 
625                 630                 635                 640 


Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys 
                645                 650                 655     


Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr Asp Met 
            660                 665                 670         


Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
        675                 680         


<210>  176
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  177
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  178
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn 
545                 550                 555                 560 


Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  179
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  179

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Leu Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  180
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  180

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  181
<211>  782
<212>  PRT
<213>  Pan troglodytes

<400>  181

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Glu Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Asp Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asn Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  182
<211>  782
<212>  PRT
<213>  Pan troglodytes

<400>  182

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Glu Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Asp Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asn Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  183
<211>  682
<212>  PRT
<213>  Pan troglodytes

<400>  183

Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala Val Phe 
1               5                   10                  15      


Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln Phe Lys Pro Ser 
            20                  25                  30          


Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp Leu Lys Gln Lys 
        35                  40                  45              


Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr Ser Asp Lys Ser 
    50                  55                  60                  


Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His Ile Ile Asp Glu 
65                  70                  75                  80  


Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr Thr Ser Ser Ile 
                85                  90                  95      


Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser Asn His Ile Asn 
            100                 105                 110         


Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln Lys Glu Asn Glu 
        115                 120                 125             


His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys Val Glu Glu Gly 
    130                 135                 140                 


Lys Leu Arg Ser Pro Asp Pro Asp Ile Leu Ala Tyr Lys Pro Gly Ser 
145                 150                 155                 160 


Glu Ser Val His Thr Val Asn Lys Pro Thr Ser Pro Ser Ala Ile Pro 
                165                 170                 175     


Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala Asn Phe Leu Ser 
            180                 185                 190         


Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly 
        195                 200                 205             


Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln Ser Glu Glu Gln 
    210                 215                 220                 


Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys Asp Arg Asn Ala 
225                 230                 235                 240 


Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala Arg 
                245                 250                 255     


Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg 
            260                 265                 270         


Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe 
        275                 280                 285             


His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu Arg 
    290                 295                 300                 


Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys Asp Glu Thr Leu 
305                 310                 315                 320 


Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro 
                325                 330                 335     


Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp Gly Gly Gly Thr 
            340                 345                 350         


Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr 
        355                 360                 365             


Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr 
    370                 375                 380                 


Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp 
385                 390                 395                 400 


Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser Gln 
                405                 410                 415     


Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr 
            420                 425                 430         


Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg Met Gly Ser Ala 
        435                 440                 445             


Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val Ala Ala 
    450                 455                 460                 


Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe Val Phe 
465                 470                 475                 480 


Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His Tyr Leu Gly Gly 
                485                 490                 495     


Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro 
            500                 505                 510         


Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp Gly 
        515                 520                 525             


Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu Cys Lys 
    530                 535                 540                 


Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu Gly Thr 
545                 550                 555                 560 


Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr Tyr Thr Ser Leu 
                565                 570                 575     


Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr Glu Glu 
            580                 585                 590         


Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr Phe Arg 
        595                 600                 605             


Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asn 
    610                 615                 620                 


Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile Glu Arg 
625                 630                 635                 640 


Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys 
                645                 650                 655     


Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr Asp Met 
            660                 665                 670         


Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
        675                 680         


<210>  184
<211>  682
<212>  PRT
<213>  Pan troglodytes

<400>  184

Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala Val Phe 
1               5                   10                  15      


Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln Phe Lys Pro Ser 
            20                  25                  30          


Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp Leu Lys Gln Lys 
        35                  40                  45              


Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr Ser Asp Lys Ser 
    50                  55                  60                  


Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His Ile Ile Asp Glu 
65                  70                  75                  80  


Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr Thr Ser Ser Ile 
                85                  90                  95      


Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser Asn His Ile Asn 
            100                 105                 110         


Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln Lys Glu Asn Glu 
        115                 120                 125             


His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys Val Glu Glu Gly 
    130                 135                 140                 


Lys Leu Arg Ser Pro Asp Pro Asp Ile Leu Ala Tyr Lys Pro Gly Ser 
145                 150                 155                 160 


Glu Ser Val His Thr Val Asn Lys Pro Thr Ser Pro Ser Ala Ile Pro 
                165                 170                 175     


Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala Asn Phe Leu Ser 
            180                 185                 190         


Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly 
        195                 200                 205             


Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln Ser Glu Glu Gln 
    210                 215                 220                 


Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys Asp Arg Asn Ala 
225                 230                 235                 240 


Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala Arg 
                245                 250                 255     


Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg 
            260                 265                 270         


Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe 
        275                 280                 285             


His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu Arg 
    290                 295                 300                 


Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys Asp Glu Thr Leu 
305                 310                 315                 320 


Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro 
                325                 330                 335     


Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp Gly Gly Gly Thr 
            340                 345                 350         


Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr 
        355                 360                 365             


Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr 
    370                 375                 380                 


Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp 
385                 390                 395                 400 


Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser Gln 
                405                 410                 415     


Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr 
            420                 425                 430         


Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg Met Gly Ser Ala 
        435                 440                 445             


Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val Ala Ala 
    450                 455                 460                 


Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe Val Phe 
465                 470                 475                 480 


Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His Tyr Leu Gly Gly 
                485                 490                 495     


Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro 
            500                 505                 510         


Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp Gly 
        515                 520                 525             


Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu Cys Lys 
    530                 535                 540                 


Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu Gly Thr 
545                 550                 555                 560 


Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr Tyr Thr Ser Leu 
                565                 570                 575     


Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr Glu Glu 
            580                 585                 590         


Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr Phe Arg 
        595                 600                 605             


Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asn 
    610                 615                 620                 


Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile Glu Arg 
625                 630                 635                 640 


Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys 
                645                 650                 655     


Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr Asp Met 
            660                 665                 670         


Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
        675                 680         


<210>  185
<211>  1327
<212>  PRT
<213>  Pan troglodytes

<400>  185

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Ala Pro Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro 
            20                  25                  30          


Glu Arg Leu Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser 
        35                  40                  45              


Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu 
    50                  55                  60                  


Glu Asn Cys Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser 
65                  70                  75                  80  


Asn His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn 
                85                  90                  95      


Phe Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr 
            100                 105                 110         


Leu Val Ser Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro 
        115                 120                 125             


Leu Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser 
    130                 135                 140                 


Arg Lys Tyr Phe His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp 
145                 150                 155                 160 


Ile Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr 
                165                 170                 175     


His Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His 
            180                 185                 190         


His Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala 
        195                 200                 205             


Thr Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp 
    210                 215                 220                 


Pro Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu 
225                 230                 235                 240 


Asn Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp 
                245                 250                 255     


Ser Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Ala Leu Leu Ser 
            260                 265                 270         


Ile Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser 
        275                 280                 285             


Lys Thr Val Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala 
    290                 295                 300                 


Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser 
305                 310                 315                 320 


Pro Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe 
                325                 330                 335     


Ser Ser Phe Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr 
            340                 345                 350         


Leu Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile 
        355                 360                 365             


Val Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly 
    370                 375                 380                 


Trp Asn Pro Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys 
385                 390                 395                 400 


Thr Trp His Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu 
                405                 410                 415     


Ile Asp Ile Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu 
            420                 425                 430         


Gly Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys 
        435                 440                 445             


Ile Pro Val Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr 
    450                 455                 460                 


Asn Trp His Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu 
465                 470                 475                 480 


Cys Val Ser Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys 
                485                 490                 495     


Glu Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser 
            500                 505                 510         


Asp Ala Glu Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe 
        515                 520                 525             


Cys Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser 
    530                 535                 540                 


Gly Tyr Tyr Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu 
545                 550                 555                 560 


Gln Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp 
                565                 570                 575     


Ser Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr 
            580                 585                 590         


Thr Trp Lys Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His 
        595                 600                 605             


Trp Asn Ala His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg 
    610                 615                 620                 


Gly Arg His Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe 
625                 630                 635                 640 


Lys Ala Met Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala 
                645                 650                 655     


Glu Tyr Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu 
            660                 665                 670         


Ser Glu Pro Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys 
        675                 680                 685             


Val Leu Met Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu 
    690                 695                 700                 


Phe Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe 
705                 710                 715                 720 


Val Asn Glu Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln 
                725                 730                 735     


Phe Trp Ile Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp 
            740                 745                 750         


Glu Trp Ser Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Asn 
        755                 760                 765             


Tyr Phe Gly Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys 
    770                 775                 780                 


Thr Leu Leu Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys 
785                 790                 795                 800 


Ile Pro Arg Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp 
                805                 810                 815     


Val Pro Trp Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe 
            820                 825                 830         


Ala Ser Glu Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser 
        835                 840                 845             


Asp Leu Leu Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser 
    850                 855                 860                 


Lys Ile Lys Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu 
865                 870                 875                 880 


Gln Glu Glu Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro 
                885                 890                 895     


Val Ile Tyr Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn 
            900                 905                 910         


Gln Ser Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly 
        915                 920                 925             


Ser Glu Glu Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys 
    930                 935                 940                 


Val Trp Leu Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr 
945                 950                 955                 960 


Cys Pro Lys Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn 
                965                 970                 975     


Ile Pro Lys Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His 
            980                 985                 990         


Phe Cys Ala Glu Glu Gly Gly Thr  Leu Val Ala Ile Glu  Ser Glu Val 
        995                 1000                 1005             


Glu Gln  Ala Phe Ile Thr Met  Asn Leu Phe Asp Gln  Thr Thr Ser 
    1010                 1015                 1020             


Val Trp  Ile Gly Leu Gln Asn  Asp Asp Tyr Glu Thr  Trp Leu Asn 
    1025                 1030                 1035             


Gly Lys  Pro Val Val Tyr Ser  Asn Trp Ser Pro Phe  Asp Ile Ile 
    1040                 1045                 1050             


Asn Ile  Pro Ser His Asn Thr  Thr Glu Val Gln Lys  His Ile Pro 
    1055                 1060                 1065             


Leu Cys  Ala Leu Leu Ser Ser  Asn Pro Asn Phe His  Phe Thr Gly 
    1070                 1075                 1080             


Lys Trp  Tyr Phe Glu Asp Cys  Gly Lys Glu Gly Tyr  Gly Phe Val 
    1085                 1090                 1095             


Cys Glu  Lys Met Gln Asp Thr  Ser Gly His Gly Val  Asn Thr Ser 
    1100                 1105                 1110             


Asp Met  Tyr Pro Met Pro Asn  Thr Leu Glu Tyr Gly  Asn Arg Thr 
    1115                 1120                 1125             


Tyr Lys  Ile Ile Asn Ala Asn  Met Thr Trp Tyr Ala  Ala Ile Lys 
    1130                 1135                 1140             


Thr Cys  Leu Met His Lys Ala  Gln Leu Val Ser Ile  Thr Asp Gln 
    1145                 1150                 1155             


Tyr His  Gln Ser Phe Leu Thr  Val Val Leu Asn Arg  Leu Gly Tyr 
    1160                 1165                 1170             


Ala His  Trp Ile Gly Leu Phe  Thr Thr Asp Asn Gly  Leu Asn Phe 
    1175                 1180                 1185             


Asp Trp  Ser Asp Gly Thr Lys  Ser Ser Phe Thr Phe  Trp Lys Asp 
    1190                 1195                 1200             


Glu Glu  Ser Ser Leu Leu Gly  Asp Cys Val Phe Ala  Asp Ser Asn 
    1205                 1210                 1215             


Gly Arg  Trp His Ser Thr Ala  Cys Glu Ser Phe Leu  Gln Gly Ala 
    1220                 1225                 1230             


Ile Cys  His Val Pro Pro Glu  Thr Arg Gln Ser Glu  His Pro Glu 
    1235                 1240                 1245             


Leu Cys  Ser Glu Thr Ser Ile  Pro Trp Ile Lys Phe  Lys Ser Asn 
    1250                 1255                 1260             


Cys Tyr  Ser Phe Ser Thr Val  Leu Asp Ser Met Ser  Phe Glu Ala 
    1265                 1270                 1275             


Ala His  Glu Phe Cys Lys Lys  Lys Gly Ser Asn Leu  Leu Thr Ile 
    1280                 1285                 1290             


Lys Asp  Glu Ala Glu Asn Ala  Phe Leu Leu Glu Glu  Leu Phe Ala 
    1295                 1300                 1305             


Phe Gly  Ser Ser Val Gln Met  Val Trp Leu Asn Ala  Gln Phe Asp 
    1310                 1315                 1320             


Gly Asn  Ser Lys 
    1325         


<210>  186
<211>  1466
<212>  PRT
<213>  Pan troglodytes

<400>  186

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Ala Pro Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro 
            20                  25                  30          


Glu Arg Leu Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser 
        35                  40                  45              


Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu 
    50                  55                  60                  


Glu Asn Cys Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser 
65                  70                  75                  80  


Asn His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn 
                85                  90                  95      


Phe Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr 
            100                 105                 110         


Leu Val Ser Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro 
        115                 120                 125             


Leu Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser 
    130                 135                 140                 


Arg Lys Tyr Phe His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp 
145                 150                 155                 160 


Ile Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr 
                165                 170                 175     


His Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His 
            180                 185                 190         


His Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala 
        195                 200                 205             


Thr Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp 
    210                 215                 220                 


Pro Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu 
225                 230                 235                 240 


Asn Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp 
                245                 250                 255     


Ser Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Ala Leu Leu Ser 
            260                 265                 270         


Ile Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser 
        275                 280                 285             


Lys Thr Val Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala 
    290                 295                 300                 


Gly Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser 
305                 310                 315                 320 


Pro Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe 
                325                 330                 335     


Ser Ser Phe Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr 
            340                 345                 350         


Leu Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile 
        355                 360                 365             


Val Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly 
    370                 375                 380                 


Trp Asn Pro Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys 
385                 390                 395                 400 


Thr Trp His Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu 
                405                 410                 415     


Ile Asp Ile Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu 
            420                 425                 430         


Gly Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys 
        435                 440                 445             


Ile Pro Val Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr 
    450                 455                 460                 


Asn Trp His Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu 
465                 470                 475                 480 


Cys Val Ser Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys 
                485                 490                 495     


Glu Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser 
            500                 505                 510         


Asp Ala Glu Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe 
        515                 520                 525             


Cys Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser 
    530                 535                 540                 


Gly Tyr Tyr Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu 
545                 550                 555                 560 


Gln Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp 
                565                 570                 575     


Ser Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr 
            580                 585                 590         


Thr Trp Lys Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His 
        595                 600                 605             


Trp Asn Ala His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg 
    610                 615                 620                 


Gly Arg His Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe 
625                 630                 635                 640 


Lys Ala Met Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala 
                645                 650                 655     


Glu Tyr Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu 
            660                 665                 670         


Ser Glu Pro Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys 
        675                 680                 685             


Val Leu Met Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu 
    690                 695                 700                 


Phe Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe 
705                 710                 715                 720 


Val Asn Glu Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln 
                725                 730                 735     


Phe Trp Ile Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp 
            740                 745                 750         


Glu Trp Ser Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Asn 
        755                 760                 765             


Tyr Phe Gly Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys 
    770                 775                 780                 


Thr Leu Leu Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys 
785                 790                 795                 800 


Ile Pro Arg Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp 
                805                 810                 815     


Val Pro Trp Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe 
            820                 825                 830         


Ala Ser Glu Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser 
        835                 840                 845             


Asp Leu Leu Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser 
    850                 855                 860                 


Lys Ile Lys Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu 
865                 870                 875                 880 


Gln Glu Glu Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro 
                885                 890                 895     


Val Ile Tyr Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn 
            900                 905                 910         


Gln Ser Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly 
        915                 920                 925             


Ser Glu Glu Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys 
    930                 935                 940                 


Val Trp Leu Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr 
945                 950                 955                 960 


Cys Pro Lys Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn 
                965                 970                 975     


Ile Pro Lys Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His 
            980                 985                 990         


Phe Cys Ala Glu Glu Gly Gly Thr  Leu Val Ala Ile Glu  Ser Glu Val 
        995                 1000                 1005             


Glu Gln  Ala Phe Ile Thr Met  Asn Leu Phe Asp Gln  Thr Thr Ser 
    1010                 1015                 1020             


Val Trp  Ile Gly Leu Gln Asn  Asp Asp Tyr Glu Thr  Trp Leu Asn 
    1025                 1030                 1035             


Gly Lys  Pro Val Val Tyr Ser  Asn Trp Ser Pro Phe  Asp Ile Ile 
    1040                 1045                 1050             


Asn Ile  Pro Ser His Asn Thr  Thr Glu Val Gln Lys  His Ile Pro 
    1055                 1060                 1065             


Leu Cys  Ala Leu Leu Ser Ser  Asn Pro Asn Phe His  Phe Thr Gly 
    1070                 1075                 1080             


Lys Trp  Tyr Phe Glu Asp Cys  Gly Lys Glu Gly Tyr  Gly Phe Val 
    1085                 1090                 1095             


Cys Glu  Lys Met Gln Asp Thr  Ser Gly His Gly Val  Asn Thr Ser 
    1100                 1105                 1110             


Asp Met  Tyr Pro Met Pro Asn  Thr Leu Glu Tyr Gly  Asn Arg Thr 
    1115                 1120                 1125             


Tyr Lys  Ile Ile Asn Ala Asn  Met Thr Trp Tyr Ala  Ala Ile Lys 
    1130                 1135                 1140             


Thr Cys  Leu Met His Lys Ala  Gln Leu Val Ser Ile  Thr Asp Gln 
    1145                 1150                 1155             


Tyr His  Gln Ser Phe Leu Thr  Val Val Leu Asn Arg  Leu Gly Tyr 
    1160                 1165                 1170             


Ala His  Trp Ile Gly Leu Phe  Thr Thr Asp Asn Gly  Leu Asn Phe 
    1175                 1180                 1185             


Asp Trp  Ser Asp Gly Thr Lys  Ser Ser Phe Thr Phe  Trp Lys Asp 
    1190                 1195                 1200             


Glu Glu  Ser Ser Leu Leu Gly  Asp Cys Val Phe Ala  Asp Ser Asn 
    1205                 1210                 1215             


Gly Arg  Trp His Ser Thr Ala  Cys Glu Ser Phe Leu  Gln Gly Ala 
    1220                 1225                 1230             


Ile Cys  His Val Pro Pro Glu  Thr Arg Gln Ser Glu  His Pro Glu 
    1235                 1240                 1245             


Leu Cys  Ser Glu Thr Ser Ile  Pro Trp Ile Lys Phe  Lys Ser Asn 
    1250                 1255                 1260             


Cys Tyr  Ser Phe Ser Thr Val  Leu Asp Ser Met Ser  Phe Glu Ala 
    1265                 1270                 1275             


Ala His  Glu Phe Cys Lys Lys  Lys Gly Ser Asn Leu  Leu Thr Ile 
    1280                 1285                 1290             


Lys Asp  Glu Ala Glu Asn Ala  Phe Leu Leu Glu Glu  Leu Phe Ala 
    1295                 1300                 1305             


Phe Gly  Ser Ser Val Gln Met  Val Trp Leu Asn Ala  Gln Phe Asp 
    1310                 1315                 1320             


Gly Asn  Asn Glu Thr Ile Lys  Trp Phe Asp Gly Thr  Pro Thr Asp 
    1325                 1330                 1335             


Gln Ser  Asn Trp Gly Ile Arg  Lys Ser Asp Thr Asp  Tyr Phe Lys 
    1340                 1345                 1350             


Pro His  His Cys Val Ala Leu  Arg Ile Pro Glu Gly  Leu Trp Gln 
    1355                 1360                 1365             


Leu Ser  Pro Cys Gln Glu Lys  Lys Gly Phe Ile Cys  Lys Met Glu 
    1370                 1375                 1380             


Ala Asp  Ile Arg Thr Ala Glu  Ser Leu Pro Glu Lys  Gly Pro Ser 
    1385                 1390                 1395             


His Ser  Ile Ile Pro Leu Ala  Val Val Leu Thr Leu  Ile Val Ile 
    1400                 1405                 1410             


Val Ala  Ile Cys Thr Leu Ser  Phe Cys Ile Tyr Lys  His Asn Gly 
    1415                 1420                 1425             


Gly Phe  Phe Arg Arg Leu Ala  Gly Phe Arg Asn Pro  Tyr Tyr Pro 
    1430                 1435                 1440             


Ala Thr  Asn Phe Ser Thr Val  His Leu Glu Glu Asn  Ile Leu Ile 
    1445                 1450                 1455             


Ser Asp  Leu Glu Lys Ser Asp  Gln 
    1460                 1465     


<210>  187
<211>  807
<212>  PRT
<213>  Rattus norvegicus

<400>  187

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Ala Asp Tyr 
            20                  25                  30          


Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Ala Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Leu Ile Thr Arg Lys 
385                 390                 395                 400 


Ala Leu Leu Thr Leu Leu Lys Thr Val Gly Ala Asp Tyr His Phe Pro 
                405                 410                 415     


Phe Ile Gln Gly Val Ser Thr Glu Gln Ser Ser Ala Ala Gly Pro His 
            420                 425                 430         


Pro Phe Phe Ser Leu Asp Arg Thr Gln Pro Pro Thr Ile Ser Leu Asn 
        435                 440                 445             


Asn Leu Glu Leu Gln Asp Leu Met Pro Val Ser Arg Ala Arg Lys Pro 
    450                 455                 460                 


Ala Phe Ile Leu Ser Ser Met Arg Asp Glu Lys Arg Ser His Asp His 
465                 470                 475                 480 


Leu Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val Ile Ile Gln 
                485                 490                 495     


Leu Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu 
            500                 505                 510         


Phe Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala 
        515                 520                 525             


Ile Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Val Tyr Phe Arg 
    530                 535                 540                 


Met Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro 
545                 550                 555                 560 


Leu Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr 
                565                 570                 575     


Asp Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg 
            580                 585                 590         


Gln Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Ala 
        595                 600                 605             


Val Arg Glu Pro Arg Cys Thr Pro Asn Ile Asn Leu Lys Pro Pro Thr 
    610                 615                 620                 


Gln Pro Ala Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala 
625                 630                 635                 640 


Ala Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu 
                645                 650                 655     


Leu Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr 
            660                 665                 670         


Asn Gln Asp Met Ile Arg Lys Gly Gln Gly Asn Lys Val Lys Lys Leu 
        675                 680                 685             


Ser Ile Val Val Ser Leu Gly Thr Gly Lys Ser Pro Gln Val Pro Val 
    690                 695                 700                 


Thr Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys 
705                 710                 715                 720 


Thr Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys 
                725                 730                 735     


Thr Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu 
            740                 745                 750         


Met Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Ser Asp 
        755                 760                 765             


Ile Met Leu Asp Glu Val Ser Asp Ala Val Leu Val Asn Ala Leu Trp 
    770                 775                 780                 


Glu Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu 
785                 790                 795                 800 


Val Gln Leu Leu Leu Ser Pro 
                805         


<210>  188
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  189
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn 
545                 550                 555                 560 


Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  190
<211>  1493
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1462)..(1462)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1465)..(1465)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1486)..(1486)
<223>  Xaa can be any naturally occurring amino acid

<400>  190

Met Ala Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu Gln Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val His Gln Gly Ser Ala Gln Asp Leu Thr His Thr Gln 
            20                  25                  30          


Glu Leu Ala Leu Glu Trp Arg Asp Lys Gly Ile Phe Ile Ile Gln Ser 
        35                  40                  45              


Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu 
    50                  55                  60                  


Glu Asn Cys Thr Gln Pro Asn Glu Tyr Met Leu Trp Lys Trp Val Ser 
65                  70                  75                  80  


Asp Asn His Leu Phe Asn Val Gly Ala Ser Gly Cys Leu Gly Leu Asn 
                85                  90                  95      


Ile Ser Asp Leu Lys Arg Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr 
            100                 105                 110         


Leu Ile Ser Leu Arg Trp Leu Cys Asp Arg Lys Thr Ile Val Gly Pro 
        115                 120                 125             


Leu Gln Tyr Lys Val Gln Val Asn His Ser Thr Val Val Ala Lys Lys 
    130                 135                 140                 


Thr Pro His Lys Trp Ser Ala Tyr Met Pro Gly Gly Gly Asp Ile Cys 
145                 150                 155                 160 


Glu His Leu His Arg Asp Ile Tyr Thr Leu Lys Gly Asn Ala His Gly 
                165                 170                 175     


Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly Gln Trp His His Glu 
            180                 185                 190         


Cys Ile Arg Glu Gly His Lys Glu His Leu Leu Trp Cys Ala Thr Thr 
        195                 200                 205             


Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr 
    210                 215                 220                 


Ser Thr Glu Ile Phe Cys Asp Ala Met Trp Gln Arg Asn Asp Asn Ser 
225                 230                 235                 240 


His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Asn Glu 
                245                 250                 255     


Ala His Ser Ser Cys Gln Met Gln Gly Gly Ala Leu Leu Ser Ile Thr 
            260                 265                 270         


Asp Glu Asn Glu Glu Ala Phe Ile Arg Lys Glu Leu Ser Arg Val Ala 
        275                 280                 285             


Lys Glu Val Trp Thr Gly Leu Asn Gln Leu Asp Glu Met Ala Gly Trp 
    290                 295                 300                 


Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser Gln Glu 
305                 310                 315                 320 


Val Thr Ala Gly Pro Phe Val Glu Tyr His Cys Gly Thr Leu Lys Val 
                325                 330                 335     


Ala Ser Ala Thr Trp Arg Ser Met Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Arg His Leu Asn His Thr Ala Glu Asp Ile Leu Gln Lys 
        355                 360                 365             


Asp Ser Trp Lys Tyr His Thr Thr His Cys Asp Pro Gly Trp Thr Pro 
    370                 375                 380                 


Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Glu Lys Arg Thr Trp Gln 
385                 390                 395                 400 


Glu Ala Leu His Ser Cys Gln Ser Asp Asp Ser Met Leu Met Asp Val 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Leu Leu Val Asn Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Ala Trp Ser Ser Gly Ser Ser Val Ile Phe Thr Asn Trp Tyr 
    450                 455                 460                 


Leu Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Asp Gln Ser Asp Gly Arg Trp Lys Val Lys Gly Cys Lys Glu Thr 
                485                 490                 495     


Leu Pro Tyr Ile Cys Lys Lys Ala Gly Gln Val Leu Glu Asp Glu Asp 
            500                 505                 510         


Ser Gly Cys Gln Ala Gly Trp Glu Arg His Gly Lys Tyr Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Glu Gln Ala Ser Gly Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Leu Thr Ile Thr Ser Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Ala Arg Lys Asp Ser Tyr Phe Trp 
                565                 570                 575     


Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp Lys Thr 
            580                 585                 590         


Met Gly Gln Arg Glu Pro Val Gln Tyr Thr His Trp Asn Ala His Gln 
        595                 600                 605             


Pro Ser Tyr His Gly Gly Cys Val Val Leu Arg Gly Gly Ser Ser Phe 
    610                 615                 620                 


Gly Arg Trp Glu Val Lys Asn Cys Ser Asp Phe Lys Ala Met Ser Leu 
625                 630                 635                 640 


Cys Lys Thr Pro Ile Lys Val Trp Glu Lys Thr Glu Phe Glu Gly Arg 
                645                 650                 655     


Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu Ser Glu Thr Gly Leu 
            660                 665                 670         


Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met Lys Arg 
        675                 680                 685             


Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala His Leu 
    690                 695                 700                 


Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Lys Leu Leu 
705                 710                 715                 720 


His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln Phe Trp Ile Gly Phe 
                725                 730                 735     


Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser Asp Gly 
            740                 745                 750         


Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala Tyr Phe Glu Glu Asp 
        755                 760                 765             


Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Asn Thr Leu Leu Pro Ser 
    770                 775                 780                 


Asn Cys Ala Ser Lys His Glu Trp Ile Cys Lys Ile Pro Arg Asp Val 
785                 790                 795                 800 


Lys Pro Asn Phe Pro Val Trp Tyr Gln Tyr Asp Ala Pro Trp Leu Phe 
                805                 810                 815     


Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His Pro Ala Glu Trp Ala 
            820                 825                 830         


Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Phe Leu Thr Ile 
        835                 840                 845             


Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser Lys Ile Arg Ala Leu 
    850                 855                 860                 


Ser Lys Tyr Gly Ala Asn Trp Trp Ile Gly Leu Glu Asp Arg Arg Ala 
865                 870                 875                 880 


Gly Asp Gln Ile His Trp Ser Asn Gly Ser Pro Val Ile Phe Gln Asn 
                885                 890                 895     


Trp Asp Lys Gly Arg Lys Gly Arg Met Asp Ser Gln Arg Lys Arg Cys 
            900                 905                 910         


Val Phe Met Ser Ala Ile Thr Gly Leu Trp Gly Thr Glu Asn Cys Ser 
        915                 920                 925             


Val Pro Met Pro Ser Ile Cys Lys Arg Val Lys Ile Trp Val Ile Glu 
    930                 935                 940                 


Lys Glu Lys Pro Pro Thr Gln His Gly Thr Cys Pro Lys Gly Trp Leu 
945                 950                 955                 960 


Tyr Phe Asn Tyr Lys Cys Phe Leu Val Thr Ile Pro Lys Asp Pro Arg 
                965                 970                 975     


Glu Leu Lys Thr Trp Thr Gly Ala Gln Glu Phe Cys Ala Ala Lys Gly 
            980                 985                 990         


Gly Thr Leu Val Ser Ile Glu Ser  Glu Leu Glu Gln Ala  Phe Ile Thr 
        995                 1000                 1005             


Val Asn  Leu Phe Gly Gln Thr  Thr Asn Val Trp Ile  Gly Leu Gln 
    1010                 1015                 1020             


Ser Asp  Asn His Glu Asn Trp  Val Asn Gly Lys Pro  Val Val Tyr 
    1025                 1030                 1035             


Ser Asn  Trp Ser Pro Ser Asp  Val Ile Asn Ile Pro  Asn Tyr Asn 
    1040                 1045                 1050             


Thr Thr  Glu Val Gln Lys Arg  Ala Pro Leu Cys Ala  Leu Met Ser 
    1055                 1060                 1065             


Ser Asn  Pro Asn Phe His Phe  Thr Gly Lys Trp Tyr  Phe Asp Asp 
    1070                 1075                 1080             


Cys Gly  Lys Lys Gly Tyr Gly  Phe Val Cys Glu Lys  Met Gln Asp 
    1085                 1090                 1095             


Thr Leu  Glu Asn His Val Asn  Val Ser Asp Thr Tyr  Ala Val Pro 
    1100                 1105                 1110             


Ser Thr  Leu Glu Tyr Gly Asn  Arg Thr Tyr Lys Ile  Ile Arg Ala 
    1115                 1120                 1125             


Asn Met  Thr Trp Tyr Ala Ala  Gly Lys Ser Cys Arg  Met Gln Gly 
    1130                 1135                 1140             


Ala Glu  Leu Val Ser Ile Pro  Asp Val Phe His Gln  Ser Phe Leu 
    1145                 1150                 1155             


Thr Val  Leu Leu Ser Arg Leu  Gly His Ala His Trp  Ile Gly Leu 
    1160                 1165                 1170             


Ser Thr  Pro Asp Asn Gly Leu  Asn Phe Asp Trp Ser  Asp Gly Thr 
    1175                 1180                 1185             


Lys Ser  Pro Phe Thr Tyr Trp  Lys Asp Glu Glu Ser  Ala Ser Leu 
    1190                 1195                 1200             


Gly Asp  Cys Val Phe Ala Asp  Thr Asp Gly His Trp  His Gly Thr 
    1205                 1210                 1215             


Ala Cys  Glu Ser His Leu Gln  Gly Ala Val Cys Arg  Val Leu Thr 
    1220                 1225                 1230             


Glu Thr  Lys Ser Phe Glu His  Pro Val Leu Cys Ser  Glu Thr Ser 
    1235                 1240                 1245             


Val Pro  Trp Ile Arg Phe Lys  Gly His Cys Tyr Ser  Phe Ser Thr 
    1250                 1255                 1260             


Val Leu  Asp Ser Arg Ser Phe  Glu Asp Ala Arg Glu  Phe Cys Lys 
    1265                 1270                 1275             


Arg Glu  Gly Ser Asn Leu Leu  Ala Ile Lys Asp Glu  Ala Glu Asn 
    1280                 1285                 1290             


Leu Phe  Leu Leu Glu Glu Leu  Leu Ala Leu Gly Ser  Ser Val Gln 
    1295                 1300                 1305             


Met Val  Trp Leu Asn Ala Gln  Leu Asp Asn Asp Asn  Lys Thr Leu 
    1310                 1315                 1320             


Arg Trp  Phe Asp Gly Ala Ala  Thr Glu Gln Ser Asn  Trp Gly Val 
    1325                 1330                 1335             


Arg Lys  Pro Asp Met Asp His  Leu Lys Pro His Pro  Cys Val Val 
    1340                 1345                 1350             


Leu Arg  Ile Pro Glu Gly Val  Trp Gln Ser Thr Pro  Cys Glu Asp 
    1355                 1360                 1365             


Lys Thr  Gly Phe Ile Cys Lys  Val Glu Ala Gly Ile  Pro Ala Val 
    1370                 1375                 1380             


Thr Ala  His Pro Glu Lys Gly  Leu Ser His Ser Ile  Met Pro Val 
    1385                 1390                 1395             


Ala Ala  Ala Leu Ala Leu Thr  Ile Val Leu Gly Ile  Leu Val Leu 
    1400                 1405                 1410             


Cys Leu  Trp Ile Tyr Lys Gln  Asn Gly Gly Ala Ile  Leu Pro Arg 
    1415                 1420                 1425             


Leu Thr  Gly Ser Arg Gly Pro  Tyr Tyr Pro Met Ser  Ser Phe Ser 
    1430                 1435                 1440             


Met Ala  His Leu Glu Glu Asn  Ile Leu Ile Ser Asp  Leu Glu Lys 
    1445                 1450                 1455             


Asn Asn  Gln Xaa Arg Ser Xaa  Ser Cys Ser Asn Tyr  Gly Glu Gln 
    1460                 1465                 1470             


Arg Arg  Pro Arg Arg Ala Ser  Cys Leu His Phe Pro  Xaa Thr Ser 
    1475                 1480                 1485             


Cys Pro  Tyr Asn Val 
    1490             


<210>  191
<211>  1493
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1462)..(1462)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1465)..(1465)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1486)..(1486)
<223>  Xaa can be any naturally occurring amino acid

<400>  191

Met Ala Gln Trp Leu Ala Met Leu Gln Leu Leu Trp Leu Gln Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val His Gln Gly Ser Ala Gln Asp Leu Thr His Thr Gln 
            20                  25                  30          


Glu Leu Ala Leu Glu Trp Arg Asp Lys Gly Ile Phe Ile Ile Gln Ser 
        35                  40                  45              


Glu Ser Leu Lys Thr Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu 
    50                  55                  60                  


Glu Asn Cys Thr Gln Pro Asn Glu Tyr Met Leu Trp Lys Trp Val Ser 
65                  70                  75                  80  


Asp Asn His Leu Phe Asn Val Gly Ala Ser Gly Cys Leu Gly Leu Asn 
                85                  90                  95      


Ile Ser Asp Leu Lys Arg Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr 
            100                 105                 110         


Leu Ile Ser Leu Arg Trp Leu Cys Asp Arg Lys Thr Ile Val Gly Pro 
        115                 120                 125             


Leu Gln Tyr Lys Val Gln Val Asn His Ser Thr Val Val Ala Lys Lys 
    130                 135                 140                 


Thr Pro His Lys Trp Ser Ala Tyr Met Pro Gly Gly Gly Asp Ile Cys 
145                 150                 155                 160 


Glu His Leu His Arg Asp Ile Tyr Thr Leu Lys Gly Asn Ala His Gly 
                165                 170                 175     


Met Pro Cys Val Phe Pro Phe Gln Phe Lys Gly Gln Trp His His Glu 
            180                 185                 190         


Cys Ile Arg Glu Gly His Lys Glu His Leu Leu Trp Cys Ala Thr Thr 
        195                 200                 205             


Ser Arg Tyr Glu Glu Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr 
    210                 215                 220                 


Ser Thr Glu Ile Phe Cys Asp Ala Met Trp Gln Arg Asn Asp Asn Ser 
225                 230                 235                 240 


His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Asn Glu 
                245                 250                 255     


Ala His Ser Ser Cys Gln Met Gln Gly Gly Ala Leu Leu Ser Ile Thr 
            260                 265                 270         


Asp Glu Asn Glu Glu Ala Phe Ile Arg Lys Glu Leu Ser Arg Val Ala 
        275                 280                 285             


Lys Glu Val Trp Thr Gly Leu Asn Gln Leu Asp Glu Met Ala Gly Trp 
    290                 295                 300                 


Gln Trp Ser Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser Gln Glu 
305                 310                 315                 320 


Val Thr Ala Gly Pro Phe Val Glu Tyr His Cys Gly Thr Leu Lys Val 
                325                 330                 335     


Ala Ser Ala Thr Trp Arg Ser Met Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Arg His Leu Asn His Thr Ala Glu Asp Ile Leu Gln Lys 
        355                 360                 365             


Asp Ser Trp Lys Tyr His Thr Thr His Cys Asp Pro Gly Trp Thr Pro 
    370                 375                 380                 


Phe Asn Arg Lys Cys Tyr Lys Leu Lys Lys Glu Lys Arg Thr Trp Gln 
385                 390                 395                 400 


Glu Ala Leu His Ser Cys Gln Ser Asp Asp Ser Met Leu Met Asp Val 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Leu Leu Val Asn Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Ala Trp Ser Ser Gly Ser Ser Val Ile Phe Thr Asn Trp Tyr 
    450                 455                 460                 


Leu Leu Glu Pro Arg Ile Leu Pro Asn Arg Arg Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Asp Gln Ser Asp Gly Arg Trp Lys Val Lys Gly Cys Lys Glu Thr 
                485                 490                 495     


Leu Pro Tyr Ile Cys Lys Lys Ala Gly Gln Val Leu Glu Asp Glu Asp 
            500                 505                 510         


Ser Gly Cys Gln Ala Gly Trp Glu Arg His Gly Lys Tyr Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Glu Gln Ala Ser Gly Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Leu Thr Ile Thr Ser Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Ala Arg Lys Asp Ser Tyr Phe Trp 
                565                 570                 575     


Ile Ala Leu Gln Asp Gln Asn Asn Thr Gly Glu Tyr Thr Trp Lys Thr 
            580                 585                 590         


Met Gly Gln Arg Glu Pro Val Gln Tyr Thr His Trp Asn Ala His Gln 
        595                 600                 605             


Pro Ser Tyr His Gly Gly Cys Val Val Leu Arg Gly Gly Ser Ser Phe 
    610                 615                 620                 


Gly Arg Trp Glu Val Lys Asn Cys Ser Asp Phe Lys Ala Met Ser Leu 
625                 630                 635                 640 


Cys Lys Thr Pro Ile Lys Val Trp Glu Lys Thr Glu Phe Glu Gly Arg 
                645                 650                 655     


Trp Pro Phe His Pro Cys Tyr Met Asp Trp Glu Ser Glu Thr Gly Leu 
            660                 665                 670         


Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met Lys Arg 
        675                 680                 685             


Ser Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala His Leu 
    690                 695                 700                 


Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Lys Leu Leu 
705                 710                 715                 720 


His Ser Lys Phe Asn Trp Thr Gln Glu Arg Gln Phe Trp Ile Gly Phe 
                725                 730                 735     


Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser Asp Gly 
            740                 745                 750         


Ser Pro Val Val Ser Ser Phe Leu Asp Asn Ala Tyr Phe Glu Glu Asp 
        755                 760                 765             


Ala Lys Asn Cys Ala Val Tyr Lys Ala Asn Asn Thr Leu Leu Pro Ser 
    770                 775                 780                 


Asn Cys Ala Ser Lys His Glu Trp Ile Cys Lys Ile Pro Arg Asp Val 
785                 790                 795                 800 


Lys Pro Asn Phe Pro Val Trp Tyr Gln Tyr Asp Ala Pro Trp Leu Phe 
                805                 810                 815     


Tyr Gln Asn Ala Glu Tyr Leu Phe His Thr His Pro Ala Glu Trp Ala 
            820                 825                 830         


Thr Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Phe Leu Thr Ile 
        835                 840                 845             


Tyr Ser Ala Gln Glu Gln Glu Phe Ile His Ser Lys Ile Arg Ala Leu 
    850                 855                 860                 


Ser Lys Tyr Gly Ala Asn Trp Trp Ile Gly Leu Glu Asp Arg Arg Ala 
865                 870                 875                 880 


Gly Asp Gln Ile His Trp Ser Asn Gly Ser Pro Val Ile Phe Gln Asn 
                885                 890                 895     


Trp Asp Lys Gly Arg Lys Gly Arg Met Asp Ser Gln Arg Lys Arg Cys 
            900                 905                 910         


Val Phe Met Ser Ala Ile Thr Gly Leu Trp Gly Thr Glu Asn Cys Ser 
        915                 920                 925             


Val Pro Met Pro Ser Ile Cys Lys Arg Val Lys Ile Trp Val Ile Glu 
    930                 935                 940                 


Lys Glu Lys Pro Pro Thr Gln His Gly Thr Cys Pro Lys Gly Trp Leu 
945                 950                 955                 960 


Tyr Phe Asn Tyr Lys Cys Val Cys Val Cys Val Pro Lys Asp Pro Arg 
                965                 970                 975     


Glu Leu Lys Thr Trp Thr Gly Ala Gln Glu Phe Cys Ala Ala Lys Gly 
            980                 985                 990         


Gly Thr Leu Val Ser Ile Glu Ser  Glu Leu Glu Gln Ala  Phe Ile Thr 
        995                 1000                 1005             


Val Asn  Leu Phe Gly Gln Thr  Thr Asn Val Trp Ile  Gly Leu Gln 
    1010                 1015                 1020             


Ser Asp  Asn His Glu Asn Trp  Val Asn Gly Lys Pro  Val Val Tyr 
    1025                 1030                 1035             


Ser Asn  Trp Ser Pro Ser Asp  Val Ile Asn Ile Pro  Asn Tyr Asn 
    1040                 1045                 1050             


Thr Thr  Glu Val Gln Lys Arg  Ala Pro Leu Cys Ala  Leu Met Ser 
    1055                 1060                 1065             


Ser Asn  Pro Asn Phe His Phe  Thr Gly Lys Trp Tyr  Phe Asp Asp 
    1070                 1075                 1080             


Cys Gly  Lys Lys Gly Tyr Gly  Phe Val Cys Glu Lys  Met Gln Asp 
    1085                 1090                 1095             


Thr Leu  Glu Asn His Val Asn  Val Ser Asp Thr Tyr  Ala Val Pro 
    1100                 1105                 1110             


Ser Thr  Leu Glu Tyr Gly Asn  Arg Thr Tyr Lys Ile  Ile Arg Ala 
    1115                 1120                 1125             


Asn Met  Thr Trp Tyr Ala Ala  Gly Lys Ser Cys Arg  Met Gln Gly 
    1130                 1135                 1140             


Ala Glu  Leu Val Ser Ile Pro  Asp Val Phe His Gln  Ser Phe Leu 
    1145                 1150                 1155             


Thr Val  Leu Leu Ser Arg Leu  Gly His Ala His Trp  Ile Gly Leu 
    1160                 1165                 1170             


Ser Thr  Pro Asp Asn Gly Leu  Asn Phe Asp Trp Ser  Asp Gly Thr 
    1175                 1180                 1185             


Lys Ser  Pro Phe Thr Tyr Trp  Lys Asp Glu Glu Ser  Ala Ser Leu 
    1190                 1195                 1200             


Gly Asp  Cys Val Phe Ala Asp  Thr Asp Gly His Trp  His Gly Thr 
    1205                 1210                 1215             


Ala Cys  Glu Ser His Leu Gln  Gly Ala Val Cys Arg  Val Leu Thr 
    1220                 1225                 1230             


Glu Thr  Lys Ser Phe Glu His  Pro Val Leu Cys Ser  Glu Thr Ser 
    1235                 1240                 1245             


Val Pro  Trp Ile Arg Phe Lys  Gly His Cys Tyr Ser  Phe Ser Thr 
    1250                 1255                 1260             


Val Leu  Asp Ser Arg Ser Phe  Glu Asp Ala Arg Glu  Phe Cys Lys 
    1265                 1270                 1275             


Arg Glu  Gly Ser Asn Leu Leu  Ala Ile Lys Asp Glu  Ala Glu Asn 
    1280                 1285                 1290             


Leu Phe  Leu Leu Glu Glu Leu  Leu Ala Leu Gly Ser  Ser Val Gln 
    1295                 1300                 1305             


Met Val  Trp Leu Asn Ala Gln  Leu Asp Asn Asp Asn  Lys Thr Leu 
    1310                 1315                 1320             


Arg Trp  Phe Asp Gly Ala Ala  Thr Glu Gln Ser Asn  Trp Gly Val 
    1325                 1330                 1335             


Arg Lys  Pro Asp Met Asp His  Leu Lys Pro His Pro  Cys Val Val 
    1340                 1345                 1350             


Leu Arg  Ile Pro Glu Gly Val  Trp Gln Ser Thr Pro  Cys Glu Asp 
    1355                 1360                 1365             


Lys Thr  Gly Phe Ile Cys Lys  Val Glu Ala Gly Ile  Pro Ala Val 
    1370                 1375                 1380             


Thr Ala  His Pro Glu Lys Gly  Leu Ser His Ser Ile  Met Pro Val 
    1385                 1390                 1395             


Ala Ala  Ala Leu Ala Leu Thr  Ile Val Leu Gly Ile  Leu Val Leu 
    1400                 1405                 1410             


Cys Leu  Trp Ile Tyr Lys Gln  Asn Gly Gly Ala Ile  Leu Pro Arg 
    1415                 1420                 1425             


Leu Thr  Gly Ser Arg Gly Pro  Tyr Tyr Pro Met Ser  Ser Phe Ser 
    1430                 1435                 1440             


Met Ala  His Leu Glu Glu Asn  Ile Leu Ile Ser Asp  Leu Glu Lys 
    1445                 1450                 1455             


Asn Asn  Gln Xaa Arg Ser Xaa  Ser Cys Ser Asn Tyr  Gly Glu Gln 
    1460                 1465                 1470             


Arg Arg  Pro Arg Arg Ala Ser  Cys Leu His Phe Pro  Xaa Thr Ser 
    1475                 1480                 1485             


Cys Pro  Tyr Asn Val 
    1490             


<210>  192
<211>  620
<212>  PRT
<213>  Macaca mulatta

<400>  192

Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala Ile Phe 
1               5                   10                  15      


Gly Asn Arg Asn Glu Met Ile Ser Arg Leu Val Gln Phe Lys Pro Ser 
            20                  25                  30          


Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp Leu Lys Gln Lys 
        35                  40                  45              


Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr Ser Asp Lys Ser 
    50                  55                  60                  


Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His Ile Ile Asp Lys 
65                  70                  75                  80  


Glu Glu Asn Arg Gly Lys Arg Ser Leu Phe His Tyr Thr Asn Ile Ile 
                85                  90                  95      


Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser Asn His Ile Asn 
            100                 105                 110         


Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Glu Lys Glu Asn Glu 
        115                 120                 125             


His Phe Gln Asp Lys Ser Lys Leu Glu Asp Lys Glu Val Glu Glu Gly 
    130                 135                 140                 


Lys Leu Ser Ser Pro Asp Pro Gly Ile Leu Ala Tyr Lys Pro Gly Ser 
145                 150                 155                 160 


Glu Ser Leu Asp Thr Val Asp Lys Pro Thr Ser Pro Ser Ala Ile Pro 
                165                 170                 175     


Asp Val Leu Pro Ile Ser Thr Lys Gln Ser Ile Ala Asn Leu Leu Ser 
            180                 185                 190         


Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly 
        195                 200                 205             


Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln Ser Glu Glu Gln 
    210                 215                 220                 


Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Arg Asp Arg Asn Ala 
225                 230                 235                 240 


Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala Arg 
                245                 250                 255     


Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg 
            260                 265                 270         


Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe 
        275                 280                 285             


His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu Arg 
    290                 295                 300                 


Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Thr Lys Asp Glu Thr Leu 
305                 310                 315                 320 


Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro 
                325                 330                 335     


Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp Gly Gly Gly Thr 
            340                 345                 350         


Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr 
        355                 360                 365             


Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr 
    370                 375                 380                 


Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp 
385                 390                 395                 400 


Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser Gln 
                405                 410                 415     


Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr 
            420                 425                 430         


Asp Ser Gln Ala Trp Glu Asn Ile Leu Arg Asp Arg Met Gly Ser Ala 
        435                 440                 445             


Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val Ala Ala 
    450                 455                 460                 


Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu 
465                 470                 475                 480 


Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu 
                485                 490                 495     


Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr His Thr 
            500                 505                 510         


Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr 
        515                 520                 525             


Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr 
    530                 535                 540                 


Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser 
545                 550                 555                 560 


Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile 
                565                 570                 575     


Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln 
            580                 585                 590         


Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr 
        595                 600                 605             


Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    610                 615                 620 


<210>  193
<211>  782
<212>  PRT
<213>  Macaca mulatta

<400>  193

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Cys Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Ile Phe Gly Asn Arg Asn Glu Met Ile Ser Arg Leu Val Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asn Arg Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Asn Ile Ile Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Glu 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Gln Asp Lys Ser Lys Leu Glu Asp Lys Glu 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Ser Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Leu Asp Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Pro Ile Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Leu Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Arg 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Thr Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Ala Trp Glu Asn Ile Leu Arg Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Asn Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


His Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  194
<211>  782
<212>  PRT
<213>  Macaca mulatta

<400>  194

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Cys Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Ile Phe Gly Asn Arg Asn Glu Met Ile Ser Arg Leu Val Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asn Arg Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Asn Ile Ile Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Glu 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Gln Asp Lys Ser Lys Leu Glu Asp Lys Glu 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Ser Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Leu Asp Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Pro Ile Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Leu Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Arg 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Thr Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Ala Trp Glu Asn Ile Leu Arg Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Asn Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


His Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  195
<211>  782
<212>  PRT
<213>  Macaca mulatta

<400>  195

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Cys Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Ile Phe Gly Asn Arg Asn Glu Met Ile Ser Arg Leu Val Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asn Arg Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Asn Ile Ile Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Glu 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Gln Asp Lys Ser Lys Leu Glu Asp Lys Glu 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Ser Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Leu Asp Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Pro Ile Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Leu Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Arg 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Thr Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Ala Trp Glu Asn Ile Leu Arg Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Asn Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


His Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  196
<211>  682
<212>  PRT
<213>  Macaca mulatta

<400>  196

Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala Ile Phe 
1               5                   10                  15      


Gly Asn Arg Asn Glu Met Ile Ser Arg Leu Val Gln Phe Lys Pro Ser 
            20                  25                  30          


Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp Leu Lys Gln Lys 
        35                  40                  45              


Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr Ser Asp Lys Ser 
    50                  55                  60                  


Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His Ile Ile Asp Lys 
65                  70                  75                  80  


Glu Glu Asn Arg Gly Lys Arg Ser Leu Phe His Tyr Thr Asn Ile Ile 
                85                  90                  95      


Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser Asn His Ile Asn 
            100                 105                 110         


Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Glu Lys Glu Asn Glu 
        115                 120                 125             


His Phe Gln Asp Lys Ser Lys Leu Glu Asp Lys Glu Val Glu Glu Gly 
    130                 135                 140                 


Lys Leu Ser Ser Pro Asp Pro Gly Ile Leu Ala Tyr Lys Pro Gly Ser 
145                 150                 155                 160 


Glu Ser Leu Asp Thr Val Asp Lys Pro Thr Ser Pro Ser Ala Ile Pro 
                165                 170                 175     


Asp Val Leu Pro Ile Ser Thr Lys Gln Ser Ile Ala Asn Leu Leu Ser 
            180                 185                 190         


Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly 
        195                 200                 205             


Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln Ser Glu Glu Gln 
    210                 215                 220                 


Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Arg Asp Arg Asn Ala 
225                 230                 235                 240 


Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala Arg 
                245                 250                 255     


Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg 
            260                 265                 270         


Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe 
        275                 280                 285             


His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu Arg 
    290                 295                 300                 


Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Thr Lys Asp Glu Thr Leu 
305                 310                 315                 320 


Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro 
                325                 330                 335     


Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp Gly Gly Gly Thr 
            340                 345                 350         


Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr 
        355                 360                 365             


Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr 
    370                 375                 380                 


Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp 
385                 390                 395                 400 


Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser Gln 
                405                 410                 415     


Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr 
            420                 425                 430         


Asp Ser Gln Ala Trp Glu Asn Ile Leu Arg Asp Arg Met Gly Ser Ala 
        435                 440                 445             


Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val Ala Ala 
    450                 455                 460                 


Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe Val Phe 
465                 470                 475                 480 


Arg Asn Tyr Gly His Phe Pro Gly Asn Asn Ser His Tyr Leu Gly Gly 
                485                 490                 495     


Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro 
            500                 505                 510         


Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp Gly 
        515                 520                 525             


Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu Cys Lys 
    530                 535                 540                 


Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu Gly Thr 
545                 550                 555                 560 


Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr His Thr Ser Leu 
                565                 570                 575     


Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr Glu Glu 
            580                 585                 590         


Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr Phe Arg 
        595                 600                 605             


Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asn 
    610                 615                 620                 


Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile Glu Arg 
625                 630                 635                 640 


Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys 
                645                 650                 655     


Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr Asp Met 
            660                 665                 670         


Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
        675                 680         


<210>  197
<211>  682
<212>  PRT
<213>  Macaca mulatta

<400>  197

Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala Ile Phe 
1               5                   10                  15      


Gly Asn Arg Asn Glu Met Ile Ser Arg Leu Val Gln Phe Lys Pro Ser 
            20                  25                  30          


Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp Leu Lys Gln Lys 
        35                  40                  45              


Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr Ser Asp Lys Ser 
    50                  55                  60                  


Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His Ile Ile Asp Lys 
65                  70                  75                  80  


Glu Glu Asn Arg Gly Lys Arg Ser Leu Phe His Tyr Thr Asn Ile Ile 
                85                  90                  95      


Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser Asn His Ile Asn 
            100                 105                 110         


Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Glu Lys Glu Asn Glu 
        115                 120                 125             


His Phe Gln Asp Lys Ser Lys Leu Glu Asp Lys Glu Val Glu Glu Gly 
    130                 135                 140                 


Lys Leu Ser Ser Pro Asp Pro Gly Ile Leu Ala Tyr Lys Pro Gly Ser 
145                 150                 155                 160 


Glu Ser Leu Asp Thr Val Asp Lys Pro Thr Ser Pro Ser Ala Ile Pro 
                165                 170                 175     


Asp Val Leu Pro Ile Ser Thr Lys Gln Ser Ile Ala Asn Leu Leu Ser 
            180                 185                 190         


Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly 
        195                 200                 205             


Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln Ser Glu Glu Gln 
    210                 215                 220                 


Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Arg Asp Arg Asn Ala 
225                 230                 235                 240 


Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala Arg 
                245                 250                 255     


Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg 
            260                 265                 270         


Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe 
        275                 280                 285             


His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu Arg 
    290                 295                 300                 


Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Thr Lys Asp Glu Thr Leu 
305                 310                 315                 320 


Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro 
                325                 330                 335     


Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp Gly Gly Gly Thr 
            340                 345                 350         


Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr 
        355                 360                 365             


Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr 
    370                 375                 380                 


Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp 
385                 390                 395                 400 


Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser Gln 
                405                 410                 415     


Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr 
            420                 425                 430         


Asp Ser Gln Ala Trp Glu Asn Ile Leu Arg Asp Arg Met Gly Ser Ala 
        435                 440                 445             


Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val Ala Ala 
    450                 455                 460                 


Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe Val Phe 
465                 470                 475                 480 


Arg Asn Tyr Gly His Phe Pro Gly Asn Asn Ser His Tyr Leu Gly Gly 
                485                 490                 495     


Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro 
            500                 505                 510         


Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp Gly 
        515                 520                 525             


Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu Cys Lys 
    530                 535                 540                 


Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu Gly Thr 
545                 550                 555                 560 


Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr His Thr Ser Leu 
                565                 570                 575     


Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr Glu Glu 
            580                 585                 590         


Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr Phe Arg 
        595                 600                 605             


Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asn 
    610                 615                 620                 


Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile Glu Arg 
625                 630                 635                 640 


Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys 
                645                 650                 655     


Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr Asp Met 
            660                 665                 670         


Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
        675                 680         


<210>  198
<211>  666
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<400>  198

Met Pro Pro Ser Cys Arg Pro Ser Thr Arg Ala Pro Ser Arg Ser Cys 
1               5                   10                  15      


Thr Leu Arg Ser Cys Ser Thr Cys Pro Thr Ser Ser Ala Thr Thr Pro 
            20                  25                  30          


Ala Gly Arg Trp Arg Thr Trp Pro Trp Arg Leu Gly Ile Arg Glu Cys 
        35                  40                  45              


Phe His His Ser Arg Ile Ile Ser Cys Ala Asn Ser Thr Glu Asn Glu 
    50                  55                  60                  


Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys Gly Asp Gly Glu 
65                  70                  75                  80  


Ile Leu Leu Glu Leu Val Gln Tyr Cys His Ala Gln Met Asp Val Thr 
                85                  90                  95      


Asp Asn Lys Gly Glu Thr Ala Phe His Tyr Ala Val Gln Gly Asp Asn 
            100                 105                 110         


Ser Gln Val Leu Gln Leu Leu Gly Lys Asn Ala Ser Thr Gly Val Asn 
        115                 120                 125             


Gln Val Asn Ser Gln Gly Leu Thr Pro Leu His Leu Ala Cys Gln Met 
    130                 135                 140                 


Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys Asn Ala Arg Cys 
145                 150                 155                 160 


Asn Ile Leu Gly Pro Glu Gly Tyr Pro Ile His Thr Ala Met Lys Phe 
                165                 170                 175     


Ser Gln Arg Gly Cys Ala Glu Met Ile Ile Ser Met Asp Ser Asn Gln 
            180                 185                 190         


Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu His Trp Ala 
        195                 200                 205             


Lys Asn Ala Glu Met Ala Arg Leu Leu Leu Lys Arg Gly Cys Asp Val 
    210                 215                 220                 


Asn Ser Thr Ser Ser Ser Gly Tyr Thr Ala Leu His Val Ala Val Met 
225                 230                 235                 240 


Arg Asn Arg Phe Glu Cys Val Met Val Leu Leu Thr Tyr Gly Ala Asn 
                245                 250                 255     


Ala Asp Ala Arg Gly Glu His Gly Asn Thr Pro Leu His Leu Ala Val 
            260                 265                 270         


Ser Lys Asp Asn Val Xaa Met Val Lys Ala Leu Ile Val Phe Gly Ala 
        275                 280                 285             


Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro Ala Phe Ile Ala 
    290                 295                 300                 


Ser Lys Ile Ser Lys Gln Leu Gln Asp Val Met His Ile Ser Arg Ala 
305                 310                 315                 320 


Arg Lys Pro Ala Phe Ile Leu Ser Ser Leu Arg Asp Glu Lys Arg Thr 
                325                 330                 335     


His Asp His Leu Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val 
            340                 345                 350         


Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr 
        355                 360                 365             


Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu 
    370                 375                 380                 


Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Val 
385                 390                 395                 400 


Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu 
                405                 410                 415     


Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr 
            420                 425                 430         


Lys Met Thr Asp Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu 
        435                 440                 445             


Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala 
    450                 455                 460                 


Pro Glu Ser Val Arg Glu Pro Arg Phe Ser Pro Asn Ile Asn Leu Lys 
465                 470                 475                 480 


Pro Leu Thr Gln Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser 
                485                 490                 495     


Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp 
            500                 505                 510         


Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile 
        515                 520                 525             


His Glu Tyr Asn Gln Asp Leu Ile Arg Lys Gly Gln Ser Glu Arg Val 
    530                 535                 540                 


Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln 
545                 550                 555                 560 


Val Pro Val Thr Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu 
                565                 570                 575     


Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val 
            580                 585                 590         


Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala 
        595                 600                 605             


Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu 
    610                 615                 620                 


Gly Ala Asp Ile Met Leu Asp Glu Val Ser Asp Ala Val Leu Val Asn 
625                 630                 635                 640 


Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Gln Phe 
                645                 650                 655     


Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            660                 665     


<210>  199
<211>  786
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  199

Met Ser Ile Asn Leu Thr Ile Asp Ile Cys Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Asn Leu Cys Gly Lys His Arg Ser Lys Gln Leu His Leu Val 
            20                  25                  30          


Cys Ser Pro Asn His Cys Trp Lys Ile Arg His Val Ser Leu Gln Arg 
        35                  40                  45              


Gly Leu His Pro His Lys Val Arg Cys Lys Trp Thr Lys Ser Glu Thr 
    50                  55                  60                  


His Ser Cys Ser Lys His Tyr Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Ser Ile Arg Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Ser Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Glu Ser Ile Lys Gln Ala Ile Arg Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Thr Glu Lys Ser Pro Val Pro Glu Gly Arg Asn His 
                165                 170                 175     


Ile Ile Asp Lys Glu Asp Asp Ile Gly Lys Gln Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Gly Asn Ile Thr Thr Lys Phe Gly Glu Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Ala Glu Lys Met Ser Gln Asp 
    210                 215                 220                 


Lys Glu Asn Ser His Phe Gln Glu Lys Ser Glu Leu Glu Gly Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Ser Ser Ser Leu Asp Pro Gly Ile Leu Thr Ser 
                245                 250                 255     


Gln Ala Asp Lys Pro Asp Pro Lys Ser Ser Ala Gly Thr Met Asp Lys 
            260                 265                 270         


Ala Thr Ser Pro Ser Gly Thr Pro Glu Ser Leu Pro Ile Ser Thr Lys 
        275                 280                 285             


Gln Ser Ile Ala Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala 
    290                 295                 300                 


Leu Val Gly Gly Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp 
305                 310                 315                 320 


Ser Lys Ser Gln Ala Glu Glu Gln Glu Glu Pro Ala Lys Ser Glu Pro 
                325                 330                 335     


Ala Gly Ser Lys Asp Lys Thr Val Glu Glu Lys Lys His Leu Ser Leu 
            340                 345                 350         


Gln Arg Glu Lys Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg 
        355                 360                 365             


Ala Leu Val Gln Ala Leu Arg Arg Thr Ala Asp Pro Lys Leu Cys Ile 
    370                 375                 380                 


Thr Arg Val Glu Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly 
385                 390                 395                 400 


Lys Gly Val Ala Val Lys Glu Arg Leu Ile Pro Cys Leu Leu Arg Leu 
                405                 410                 415     


Arg Gln Met Lys Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu 
            420                 425                 430         


Ala Leu Ile Gly Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile 
        435                 440                 445             


Leu Thr Ile Asp Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr 
    450                 455                 460                 


Leu Arg Lys Leu Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe 
465                 470                 475                 480 


Asp Tyr Ile Cys Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu 
                485                 490                 495     


Gly Leu Phe His Leu Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys 
            500                 505                 510         


Leu Gly Ser Asp Ile Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys 
        515                 520                 525             


Met Ser Trp Ser His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Lys Ile 
    530                 535                 540                 


Leu Lys Glu Arg Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn 
545                 550                 555                 560 


Pro Met Cys Pro Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly 
                565                 570                 575     


Ser Thr Pro Lys Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly 
            580                 585                 590         


Ser Gln Ser His Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala 
        595                 600                 605             


Ile Arg Ala Ser Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu 
    610                 615                 620                 


Gly Asn Asp Leu His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser 
625                 630                 635                 640 


Ala Leu Ala Met His Glu Cys Lys Cys Leu Trp Pro Asp Ala Pro Leu 
                645                 650                 655     


Glu Cys Ile Val Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg 
            660                 665                 670         


Asn Asn Thr Thr Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile 
        675                 680                 685             


Asn Ser Ala Thr Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu 
    690                 695                 700                 


Leu Pro Pro Asp Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn 
705                 710                 715                 720 


Ile Pro Leu Asp Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu 
                725                 730                 735     


Glu Gly Ser Lys Tyr Ile Glu Arg Asn Glu His Lys Met Lys Lys Val 
            740                 745                 750         


Ala Lys Ile Leu Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp 
        755                 760                 765             


Trp Ile Lys Leu Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser 
    770                 775                 780                 


Lys Leu 
785     


<210>  200
<211>  1499
<212>  PRT
<213>  Canis familiaris

<400>  200

Met Arg Ala Glu Ser Gln Glu Gly Gln Ala His Phe Ser Thr Val Leu 
1               5                   10                  15      


Trp Asp Cys Ser Phe Lys Tyr Asn Ala His Ala Ala Ser Ile Arg Asn 
            20                  25                  30          


Ser Leu Leu Ile Gly Leu Glu Ser Arg Ile Lys Asn Pro Asp Phe Leu 
        35                  40                  45              


His His Ser Ala Met Asn Arg Thr Arg Phe Ser Gly Leu Gln His Pro 
    50                  55                  60                  


Phe Leu Leu Gln Ser Asn Leu Asn Lys Gly Met Phe Leu Ile Gln Ser 
65                  70                  75                  80  


Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu 
                85                  90                  95      


Glu Asn Cys Lys Pro Pro Asn Lys His Met Leu Trp Lys Trp Val Ser 
            100                 105                 110         


Asn His His Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn 
        115                 120                 125             


Leu Ser Asn Pro Glu Gln Pro Leu Ser Ile Tyr Glu Cys Asp Ser Thr 
    130                 135                 140                 


His Val Ser Leu Arg Trp His Cys Asn Lys Asn Met Ile Ile Gly Pro 
145                 150                 155                 160 


Leu Gln Tyr Thr Val Gln Val Asn Asp Asn Asn Met Leu Val Ala Ser 
                165                 170                 175     


Trp Lys Tyr Leu His Lys Trp Ile Ser Tyr Leu Ser Asp Gly Gly Ser 
            180                 185                 190         


Ile Cys Glu Tyr Leu His Lys Asp Met Tyr Thr Ile Lys Gly Asn Ala 
        195                 200                 205             


His Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn Arg Gln Trp His 
    210                 215                 220                 


His Glu Cys Thr Gln Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala 
225                 230                 235                 240 


Thr Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp 
                245                 250                 255     


Pro Thr Ser Thr Glu Val Gly Cys Asp Ala Val Trp Glu Lys Asp Leu 
            260                 265                 270         


Asn Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp 
        275                 280                 285             


Ser Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Ala Leu Leu Ser 
    290                 295                 300                 


Ile Ala Asp Glu Asn Glu Glu Asn Phe Ile Arg Lys His Leu Gly Ser 
305                 310                 315                 320 


Glu Ala Val Glu Met Trp Met Gly Leu Asn Gln Leu Asp Glu Asn Ala 
                325                 330                 335     


Gly Trp Gln Trp Ser Asp Arg Thr Pro Leu Asn Tyr Leu Asn Trp Asn 
            340                 345                 350         


Pro Glu Ile Asn Phe Glu Pro Phe Val Glu Tyr His Cys Gly Thr Phe 
        355                 360                 365             


Asn Ser Phe Leu Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr 
    370                 375                 380                 


Leu Pro Tyr Ile Cys Lys Lys Tyr Leu Asn Asn Thr Asp Gln Glu Val 
385                 390                 395                 400 


Ile Glu Lys Asp Ala Trp Lys Tyr Tyr Thr Thr His Cys Glu Pro Gly 
                405                 410                 415     


Trp Asn Pro His Ser His Asn Cys Tyr Lys Leu Gln Lys Glu Lys Arg 
            420                 425                 430         


Thr Trp Asn Glu Ala Leu His Ser Cys Gln Ser Asp Asn Ser Thr Leu 
        435                 440                 445             


Ile Asn Ile Ala Ser Leu Ala Asp Val Glu Phe Phe Val Thr Leu Leu 
    450                 455                 460                 


Gly Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys 
465                 470                 475                 480 


Ile Pro Val Ser Phe Glu Trp Ser Asn Gly Ser Ser Val Thr Phe Thr 
                485                 490                 495     


Asn Trp His Thr Leu Glu Pro Gln Ile Phe Pro Asn Gly Ser Gln Gln 
            500                 505                 510         


Cys Val Ser Ala Glu Gln Ser Glu Gly Arg Trp Lys Val Lys Asn Cys 
        515                 520                 525             


Glu Glu Thr Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser 
    530                 535                 540                 


Asp Thr Glu Ser Gly Cys Gln Lys Gly Trp Glu Arg His Gly Gly Phe 
545                 550                 555                 560 


Cys Tyr Lys Ile Asp Thr Val Leu Arg Thr Phe Asp His Ala Ser Ser 
                565                 570                 575     


Gly Tyr His Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu 
            580                 585                 590         


Gln Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Val Lys Thr Lys Asn 
        595                 600                 605             


Ser Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr 
    610                 615                 620                 


Thr Trp Lys Thr Ala Trp Gly Gln Lys Ser Glu Pro Val Gln Tyr Thr 
625                 630                 635                 640 


His Trp Asn Ala Arg Gln Pro Arg Tyr Ser Gly Gly Cys Val Val Met 
                645                 650                 655     


Arg Gly Arg Ser Pro Pro Gly Arg Trp Glu Val Lys Asp Cys Arg His 
            660                 665                 670         


Phe Lys Ala Met Ser Leu Cys Lys Gln Pro Val Gly Lys Gln Glu Lys 
        675                 680                 685             


Thr Glu Gln Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp 
    690                 695                 700                 


Glu Ser Glu Pro Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu 
705                 710                 715                 720 


Lys Val Leu Met Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu 
                725                 730                 735     


Glu Phe Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn 
            740                 745                 750         


Phe Val Asn Glu Leu Leu His Ser Lys Phe Asn Arg Thr Glu Glu Arg 
        755                 760                 765             


Gln Phe Trp Ile Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser 
    770                 775                 780                 


Trp Glu Trp Ser Asp Gly Thr Pro Val Val Ser Ser Phe Leu Asp Asn 
785                 790                 795                 800 


Thr Tyr Phe Gly Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn 
                805                 810                 815     


Lys Thr Leu Leu Pro Leu His Cys Ser Ser Lys Arg Glu Trp Ile Cys 
            820                 825                 830         


Lys Ile Pro Arg Asp Val Arg Pro Lys Ile Pro Pro Trp Tyr Gln Tyr 
        835                 840                 845             


Asp Ala Pro Trp Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr 
    850                 855                 860                 


Tyr Ala Ala Glu Trp Pro Ser Phe Glu Phe Val Cys Val Trp Leu Arg 
865                 870                 875                 880 


Gly Asp Ile Leu Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His 
                885                 890                 895     


Ser Lys Ile Arg Ala Leu Ser Lys Tyr Gly Val Asn Trp Trp Ile Gly 
            900                 905                 910         


Leu Arg Glu Glu Arg Ala Asn Asp Glu Phe Arg Trp Asn Asp Gly Ala 
        915                 920                 925             


Pro Val Ile Tyr Gln Asn Trp Asp Lys Arg Arg Glu Gly Ser Met Ser 
    930                 935                 940                 


Asn Gln Ser Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp 
945                 950                 955                 960 


Ala Ser Glu Glu Cys Ser Val Ser Leu Pro Gly Ile Cys Lys Arg Lys 
                965                 970                 975     


Lys Ile Trp Val Ile Glu Lys Glu Lys Asp Thr Pro Lys Gln His Gly 
            980                 985                 990         


Thr Cys Pro Lys Gly Trp Leu Tyr  Phe Asn Tyr Lys Cys  Leu Leu Met 
        995                 1000                 1005             


Lys Ile  Pro Lys Asp Pro Ser  Asp Trp Lys Asn Trp  Thr Ser Ala 
    1010                 1015                 1020             


Gln Asp  Phe Cys Val Glu Glu  Gly Gly Thr Leu Val  Ala Ile Glu 
    1025                 1030                 1035             


Asn Glu  Val Glu Gln Ala Phe  Ile Thr Met Asn Leu  Phe Gly Gln 
    1040                 1045                 1050             


Thr Thr  Asn Val Trp Ile Gly  Leu Gln Asn Asp Asn  Tyr Glu Lys 
    1055                 1060                 1065             


Trp Leu  Asn Gly Lys Pro Leu  Ala Tyr Ser Asn Trp  Ser Pro Phe 
    1070                 1075                 1080             


Asp Val  Ile Asn Ile Pro Ser  His Asn Thr Thr Glu  Val Gln Lys 
    1085                 1090                 1095             


His Ile  Pro Leu Cys Ala Leu  Leu Ser Ser Asn Pro  Asn Phe His 
    1100                 1105                 1110             


Phe Thr  Gly Lys Trp Tyr Phe  Glu Asp Cys Gly Lys  Glu Gly His 
    1115                 1120                 1125             


Gly Phe  Val Cys Glu Lys Met  Gln Asp Thr Ser Gly  His Thr Val 
    1130                 1135                 1140             


Asn Thr  Ser Asp Met Tyr Pro  Val Pro Asp Thr Leu  Glu Tyr Gly 
    1145                 1150                 1155             


Asn Arg  Thr Tyr Lys Ile Ile  Asn Ala Asn Met Thr  Trp Tyr Thr 
    1160                 1165                 1170             


Ala Ile  Lys Thr Cys Leu Met  His Gly Ala Glu Leu  Ala Ser Ile 
    1175                 1180                 1185             


Thr Asp  Gln Tyr His Gln Ser  Phe Leu Thr Val Ile  Leu Asn Arg 
    1190                 1195                 1200             


Leu Gly  His Ala His Trp Ile  Gly Leu Phe Thr Ala  Asp Asn Gly 
    1205                 1210                 1215             


Leu Asn  Phe Asp Trp Ser Asp  Gly Thr Lys Ser Ser  Phe Thr Phe 
    1220                 1225                 1230             


Trp Lys  Asp Asp Glu Ser Ser  Ile Leu Gly Asp Cys  Val Phe Ala 
    1235                 1240                 1245             


Asp Thr  Ser Gly Arg Trp Ser  Ser Thr Ala Cys Glu  Ser Phe Leu 
    1250                 1255                 1260             


Gln Gly  Ala Ile Cys His Val  Pro Ser Glu Thr Lys  Gln Phe Gly 
    1265                 1270                 1275             


His Pro  Glu Leu Cys Ser Glu  Thr Ser Ile Pro Trp  Ile Lys Phe 
    1280                 1285                 1290             


Lys Ser  Asn Cys Tyr Ser Phe  Ser Thr Val Leu Asp  Ser Met Ser 
    1295                 1300                 1305             


Phe Glu  Ala Ala His Glu Phe  Cys Lys Lys Glu Gly  Ser Asn Leu 
    1310                 1315                 1320             


Leu Thr  Ile Lys Asp Glu Asp  Glu Asn Ser Phe Leu  Leu Glu Glu 
    1325                 1330                 1335             


Leu Ser  Ala Phe Gly Ser Ser  Val Gln Met Ile Trp  Leu Asn Ala 
    1340                 1345                 1350             


Gln Phe  Asp Gly Asp Ser Lys  Thr Ile Lys Trp Phe  Asp Gly Thr 
    1355                 1360                 1365             


Pro Thr  Asp Gln Ser Asn Trp  Gly Ile Arg Lys Pro  Glu Met Asp 
    1370                 1375                 1380             


His Val  Lys Pro His Leu Cys  Ile Ala Leu Arg Ile  Ser Glu Gly 
    1385                 1390                 1395             


Val Trp  Gln Leu Ser Pro Cys  Gln Glu Lys Lys Gly  Phe Ile Cys 
    1400                 1405                 1410             


Lys Met  Glu Ala Gly Leu His  Ala Val Lys Glu His  Ser Gly Lys 
    1415                 1420                 1425             


Gly Pro  Ser His Ser Met Val  Pro Leu Ala Val Ala  Leu Thr Leu 
    1430                 1435                 1440             


Ile Val  Ile Leu Ala Leu Ser  Thr Leu Ser Phe Cys  Ile Tyr Lys 
    1445                 1450                 1455             


His Asn  Arg Gly Ile Phe Ser  Arg Leu Ala Pro Phe  Gly Asn Pro 
    1460                 1465                 1470             


Tyr Tyr  Pro Thr Asn Asn Phe  Ser Thr Val His Leu  Glu Glu Asn 
    1475                 1480                 1485             


Ile Leu  Ile Ser Asp Leu Glu  Lys Asn Asp Pro 
    1490                 1495                 


<210>  201
<211>  785
<212>  PRT
<213>  Canis familiaris

<400>  201

Met Ser Ile Asn Leu Thr Ile Asp Ile Tyr Tyr Ile Tyr Leu Leu Ser 
1               5                   10                  15      


Asn Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe 
            20                  25                  30          


Leu Cys Ser Pro Lys His Tyr Trp Arg Ile Ser His Leu Ser Leu Gln 
        35                  40                  45              


Arg Gly Phe His Gly Ser Lys Thr Arg Cys Lys Leu Thr Lys Ser Glu 
    50                  55                  60                  


Ala His Ser Cys Ser Asn His Cys His Ser Pro Ser Thr His Gly Leu 
65                  70                  75                  80  


His Ile Gly Ile Leu Lys Leu Ser Thr Ser Thr Pro Lys Gly Leu Thr 
                85                  90                  95      


Lys Val Ser Ile Arg Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val 
            100                 105                 110         


Ser Lys Ala Val Phe Gly Thr Gln Asn Glu Met Ile Ser Arg Leu Ala 
        115                 120                 125             


Gln Phe Lys Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Ser Gly 
    130                 135                 140                 


Trp Leu Lys Gln Lys Ser Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys 
145                 150                 155                 160 


Tyr Ser Asp Lys Ser Val Glu Asn Asn Ser Phe Ser Gly Lys Gln Ser 
                165                 170                 175     


Tyr Ile Leu Gly Lys Asp Glu Asp Ile Gly Lys Gln Ser Leu Phe Arg 
            180                 185                 190         


Tyr Thr Ser Ser Ile Thr Thr Arg Phe Gly Glu Ser Phe Tyr Phe Leu 
        195                 200                 205             


Ser Asn His Ile Asn Ser Tyr Phe Lys Arg Glu Ala Arg Met Ser Lys 
    210                 215                 220                 


Lys Lys Glu Asn Lys His Phe Gln Glu Lys Ser Glu Leu Glu Asp Lys 
225                 230                 235                 240 


Lys Val Glu Glu Glu Lys Ala Ser Ser Pro Asp Pro Gly Ile Leu Ile 
                245                 250                 255     


Asp Lys Leu Asp Ser Glu Ser Ser Val Tyr Ser Val Asp Lys Pro Ala 
            260                 265                 270         


Ser Thr Ser Gly Thr Pro Glu Ala Leu Pro Val Ser Thr Lys Gln Ser 
        275                 280                 285             


Ile Ala Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val 
    290                 295                 300                 


Gly Gly Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys 
305                 310                 315                 320 


Ser Gln Pro Glu Glu Gln Glu Glu Val Ile Lys Ala Glu Gln Pro Val 
                325                 330                 335     


Ser Lys Asp Lys Asn Val Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg 
            340                 345                 350         


Glu Lys Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu 
        355                 360                 365             


Val Gln Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Asn Arg 
    370                 375                 380                 


Val Glu Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly 
385                 390                 395                 400 


Val Ala Val Lys Tyr Asn Thr Tyr Ala Val Ile Gly Ile Lys Leu Arg 
                405                 410                 415     


Gln Ile Lys Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ala Leu Ala 
            420                 425                 430         


Leu Ile Gly Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu 
        435                 440                 445             


Thr Ile Asp Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu 
    450                 455                 460                 


Arg Lys Leu Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp 
465                 470                 475                 480 


Tyr Ile Cys Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly 
                485                 490                 495     


Leu Phe His Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu 
            500                 505                 510         


Gly Ser Asp Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met 
        515                 520                 525             


Ser Trp Ser His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu 
    530                 535                 540                 


Lys Asp Arg Met Gly Ser Ser Leu Met Ile Glu Thr Ala Arg Asn Pro 
545                 550                 555                 560 


Ser Cys Pro Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile 
                565                 570                 575     


Thr Pro Lys Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile 
            580                 585                 590         


Asn Ser His Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile 
        595                 600                 605             


Arg Ala Ser Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly 
    610                 615                 620                 


Asn Asp Leu His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala 
625                 630                 635                 640 


Leu Ala Met His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu 
                645                 650                 655     


Cys Ile Val Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn 
            660                 665                 670         


Ser Val Thr Ser Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn 
        675                 680                 685             


Ser Ala Thr Asp Thr Glu Glu Val His Val Met Leu Asp Gly Leu Leu 
    690                 695                 700                 


Pro Pro Asp Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile 
705                 710                 715                 720 


Pro Leu Asp Glu Ser Arg Asn Glu Lys Leu Asn Gln Leu Gln Leu Glu 
                725                 730                 735     


Gly Leu Lys Tyr Ile Glu Arg Asn Glu Glu Lys Met Lys Lys Leu Ala 
            740                 745                 750         


Lys Ile Leu Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp 
        755                 760                 765             


Ile Lys Leu Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys 
    770                 775                 780                 


Leu 
785 


<210>  202
<211>  722
<212>  PRT
<213>  Canis familiaris

<400>  202

Met Ser Ile Asn Leu Thr Ile Asp Ile Tyr Tyr Ile Tyr Leu Leu Ser 
1               5                   10                  15      


Asn Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe 
            20                  25                  30          


Leu Cys Ser Pro Lys His Tyr Trp Arg Ile Ser His Leu Ser Leu Gln 
        35                  40                  45              


Arg Gly Phe His Gly Ser Lys Thr Arg Cys Lys Leu Thr Lys Ser Glu 
    50                  55                  60                  


Ala His Ser Cys Ser Asn His Cys His Ser Pro Ser Thr His Gly Leu 
65                  70                  75                  80  


His Ile Gly Ile Leu Lys Leu Ser Thr Ser Thr Pro Lys Gly Leu Thr 
                85                  90                  95      


Lys Val Ser Ile Arg Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val 
            100                 105                 110         


Ser Lys Ala Val Phe Gly Thr Gln Asn Glu Met Ile Ser Arg Leu Ala 
        115                 120                 125             


Gln Phe Lys Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Ser Gly 
    130                 135                 140                 


Trp Leu Lys Gln Lys Ser Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys 
145                 150                 155                 160 


Tyr Ser Asp Lys Ser Val Glu Asn Asn Ser Phe Ser Gly Lys Gln Ser 
                165                 170                 175     


Tyr Ile Leu Gly Lys Asp Glu Asp Ile Gly Lys Gln Ser Leu Phe Arg 
            180                 185                 190         


Tyr Thr Ser Ser Ile Thr Thr Arg Phe Gly Glu Ser Phe Tyr Phe Leu 
        195                 200                 205             


Ser Asn His Ile Asn Ser Tyr Phe Lys Arg Glu Ala Arg Met Ser Lys 
    210                 215                 220                 


Lys Lys Glu Asn Lys His Phe Gln Glu Lys Ser Glu Leu Glu Asp Lys 
225                 230                 235                 240 


Lys Val Glu Glu Glu Lys Ala Ser Ser Pro Asp Pro Gly Ile Leu Ile 
                245                 250                 255     


Asp Lys Leu Asp Ser Glu Ser Ser Val Tyr Ser Val Asp Lys Pro Ala 
            260                 265                 270         


Ser Thr Ser Gly Thr Pro Glu Ala Leu Pro Val Ser Thr Lys Gln Ser 
        275                 280                 285             


Ile Ala Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val 
    290                 295                 300                 


Gly Gly Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys 
305                 310                 315                 320 


Ser Gln Pro Glu Glu Gln Glu Glu Val Ile Lys Ala Glu Gln Pro Val 
                325                 330                 335     


Ser Lys Asp Lys Asn Val Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg 
            340                 345                 350         


Glu Lys Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu 
        355                 360                 365             


Val Gln Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Asn Arg 
    370                 375                 380                 


Val Glu Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly 
385                 390                 395                 400 


Val Ala Val Lys Glu Lys Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln 
                405                 410                 415     


Ile Lys Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ala Leu Ala Leu 
            420                 425                 430         


Ile Gly Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Thr 
        435                 440                 445             


Ile Asp Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg 
    450                 455                 460                 


Lys Leu Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr 
465                 470                 475                 480 


Ile Cys Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu 
                485                 490                 495     


Phe His Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly 
            500                 505                 510         


Ser Asp Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser 
        515                 520                 525             


Trp Ser His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys 
    530                 535                 540                 


Asp Arg Met Gly Ser Ser Leu Met Ile Glu Thr Ala Arg Asn Pro Ser 
545                 550                 555                 560 


Cys Pro Lys Val Ala Ala Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser 
                565                 570                 575     


Ala Leu Ala Met His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu 
            580                 585                 590         


Glu Cys Ile Val Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg 
        595                 600                 605             


Asn Ser Val Thr Ser Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile 
    610                 615                 620                 


Asn Ser Ala Thr Asp Thr Glu Glu Val His Val Met Leu Asp Gly Leu 
625                 630                 635                 640 


Leu Pro Pro Asp Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn 
                645                 650                 655     


Ile Pro Leu Asp Glu Ser Arg Asn Glu Lys Leu Asn Gln Leu Gln Leu 
            660                 665                 670         


Glu Gly Leu Lys Tyr Ile Glu Arg Asn Glu Glu Lys Met Lys Lys Leu 
        675                 680                 685             


Ala Lys Ile Leu Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp 
    690                 695                 700                 


Trp Ile Lys Leu Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser 
705                 710                 715                 720 


Lys Leu 
        


<210>  203
<211>  784
<212>  PRT
<213>  Canis familiaris

<400>  203

Met Ser Ile Asn Leu Thr Ile Asp Ile Tyr Tyr Ile Tyr Leu Leu Ser 
1               5                   10                  15      


Asn Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe 
            20                  25                  30          


Leu Cys Ser Pro Lys His Tyr Trp Arg Ile Ser His Leu Ser Leu Gln 
        35                  40                  45              


Arg Gly Phe His Gly Ser Lys Thr Arg Cys Lys Leu Thr Lys Ser Glu 
    50                  55                  60                  


Ala His Ser Cys Ser Asn His Cys His Ser Pro Ser Thr His Gly Leu 
65                  70                  75                  80  


His Ile Gly Ile Leu Lys Leu Ser Thr Ser Thr Pro Lys Gly Leu Thr 
                85                  90                  95      


Lys Val Ser Ile Arg Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val 
            100                 105                 110         


Ser Lys Ala Val Phe Gly Thr Gln Asn Glu Met Ile Ser Arg Leu Ala 
        115                 120                 125             


Gln Phe Lys Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Ser Gly 
    130                 135                 140                 


Trp Leu Lys Gln Lys Ser Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys 
145                 150                 155                 160 


Tyr Ser Asp Lys Ser Val Glu Asn Asn Ser Phe Ser Gly Lys Gln Ser 
                165                 170                 175     


Tyr Ile Leu Gly Lys Asp Glu Asp Ile Gly Lys Gln Ser Leu Phe Arg 
            180                 185                 190         


Tyr Thr Ser Ser Ile Thr Thr Arg Phe Gly Glu Ser Phe Tyr Phe Leu 
        195                 200                 205             


Ser Asn His Ile Asn Ser Tyr Phe Lys Arg Glu Ala Arg Met Ser Lys 
    210                 215                 220                 


Lys Lys Glu Asn Lys His Phe Gln Glu Lys Ser Glu Leu Glu Asp Lys 
225                 230                 235                 240 


Lys Val Glu Glu Glu Lys Ala Ser Ser Pro Asp Pro Gly Ile Leu Ile 
                245                 250                 255     


Asp Lys Leu Asp Ser Glu Ser Ser Val Tyr Ser Val Asp Lys Pro Ala 
            260                 265                 270         


Ser Thr Ser Gly Thr Pro Glu Ala Leu Pro Val Ser Thr Lys Gln Ser 
        275                 280                 285             


Ile Ala Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val 
    290                 295                 300                 


Gly Gly Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys 
305                 310                 315                 320 


Ser Gln Pro Glu Glu Gln Glu Glu Val Ile Lys Ala Glu Gln Pro Val 
                325                 330                 335     


Ser Lys Asp Lys Asn Val Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg 
            340                 345                 350         


Glu Lys Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu 
        355                 360                 365             


Val Gln Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Asn Arg 
    370                 375                 380                 


Val Glu Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly 
385                 390                 395                 400 


Val Ala Val Lys Glu Lys Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln 
                405                 410                 415     


Ile Lys Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ala Leu Ala Leu 
            420                 425                 430         


Ile Gly Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Thr 
        435                 440                 445             


Ile Asp Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg 
    450                 455                 460                 


Lys Leu Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr 
465                 470                 475                 480 


Ile Cys Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu 
                485                 490                 495     


Phe His Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly 
            500                 505                 510         


Ser Asp Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser 
        515                 520                 525             


Trp Ser His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys 
    530                 535                 540                 


Asp Arg Met Gly Ser Ser Leu Met Ile Glu Thr Ala Arg Asn Pro Ser 
545                 550                 555                 560 


Cys Pro Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr 
                565                 570                 575     


Pro Lys Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn 
            580                 585                 590         


Ser His Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg 
        595                 600                 605             


Ala Ser Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn 
    610                 615                 620                 


Asp Leu His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu 
625                 630                 635                 640 


Ala Met His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys 
                645                 650                 655     


Ile Val Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Ser 
            660                 665                 670         


Val Thr Ser Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser 
        675                 680                 685             


Ala Thr Asp Thr Glu Glu Val His Val Met Leu Asp Gly Leu Leu Pro 
    690                 695                 700                 


Pro Asp Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro 
705                 710                 715                 720 


Leu Asp Glu Ser Arg Asn Glu Lys Leu Asn Gln Leu Gln Leu Glu Gly 
                725                 730                 735     


Leu Lys Tyr Ile Glu Arg Asn Glu Glu Lys Met Lys Lys Leu Ala Lys 
            740                 745                 750         


Ile Leu Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile 
        755                 760                 765             


Lys Leu Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780                 


<210>  204
<211>  683
<212>  PRT
<213>  Canis familiaris

<400>  204

Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala Val Phe 
1               5                   10                  15      


Gly Thr Gln Asn Glu Met Ile Ser Arg Leu Ala Gln Phe Lys Pro Ser 
            20                  25                  30          


Ser Arg Ile Leu Arg Lys Val Ser Asp Ser Gly Trp Leu Lys Gln Lys 
        35                  40                  45              


Ser Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr Ser Asp Lys Ser 
    50                  55                  60                  


Val Glu Asn Asn Ser Phe Ser Gly Lys Gln Ser Tyr Ile Leu Gly Lys 
65                  70                  75                  80  


Asp Glu Asp Ile Gly Lys Gln Ser Leu Phe Arg Tyr Thr Ser Ser Ile 
                85                  90                  95      


Thr Thr Arg Phe Gly Glu Ser Phe Tyr Phe Leu Ser Asn His Ile Asn 
            100                 105                 110         


Ser Tyr Phe Lys Arg Glu Ala Arg Met Ser Lys Lys Lys Glu Asn Lys 
        115                 120                 125             


His Phe Gln Glu Lys Ser Glu Leu Glu Asp Lys Lys Val Glu Glu Glu 
    130                 135                 140                 


Lys Ala Ser Ser Pro Asp Pro Gly Ile Leu Ile Asp Lys Leu Asp Ser 
145                 150                 155                 160 


Glu Ser Ser Val Tyr Ser Val Asp Lys Pro Ala Ser Thr Ser Gly Thr 
                165                 170                 175     


Pro Glu Ala Leu Pro Val Ser Thr Lys Gln Ser Ile Ala Asn Phe Leu 
            180                 185                 190         


Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly 
        195                 200                 205             


Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln Pro Glu Glu 
    210                 215                 220                 


Gln Glu Glu Val Ile Lys Ala Glu Gln Pro Val Ser Lys Asp Lys Asn 
225                 230                 235                 240 


Val Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala 
                245                 250                 255     


Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg 
            260                 265                 270         


Arg Thr Thr Asp Pro Lys Leu Cys Ile Asn Arg Val Glu Glu Leu Thr 
        275                 280                 285             


Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu 
    290                 295                 300                 


Lys Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys Asp Glu Thr 
305                 310                 315                 320 


Leu Gln Ala Ala Val Arg Glu Ala Leu Ala Leu Ile Gly Tyr Val Asp 
                325                 330                 335     


Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Thr Ile Asp Gly Gly Gly 
            340                 345                 350         


Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu 
        355                 360                 365             


Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser 
    370                 375                 380                 


Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu 
385                 390                 395                 400 


Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser 
                405                 410                 415     


Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe 
            420                 425                 430         


Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg Met Gly Ser 
        435                 440                 445             


Ser Leu Met Ile Glu Thr Ala Arg Asn Pro Ser Cys Pro Lys Val Ala 
    450                 455                 460                 


Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe Val 
465                 470                 475                 480 


Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His Tyr Leu Gly 
                485                 490                 495     


Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala 
            500                 505                 510         


Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp 
        515                 520                 525             


Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu Cys 
    530                 535                 540                 


Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu Gly 
545                 550                 555                 560 


Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Ser Val Thr Ser Thr Ser 
                565                 570                 575     


Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr Glu 
            580                 585                 590         


Glu Val His Val Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr Phe 
        595                 600                 605             


Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg 
    610                 615                 620                 


Asn Glu Lys Leu Asn Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile Glu 
625                 630                 635                 640 


Arg Asn Glu Glu Lys Met Lys Lys Leu Ala Lys Ile Leu Ser Gln Glu 
                645                 650                 655     


Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr Asp 
            660                 665                 670         


Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
        675                 680             


<210>  205
<211>  806
<212>  PRT
<213>  Canis familiaris

<400>  205

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Ala Arg Val Arg Asp Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Ile Pro Asn Arg Thr Trp Asp Cys Ile Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Thr Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Lys His Val Leu His Thr Glu Val Leu Gln Gln Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Ser His Pro Ser Trp Ser Ala Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Asn Arg Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Asn Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Arg Val Asn Asn Gln Gly Gln Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Thr Gly Tyr Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Cys His Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asn Ser Thr Ser Cys Val Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Ser Ile Ala Ser Lys Ile Ser Lys Leu Val Thr Arg Lys 
385                 390                 395                 400 


Thr Leu Leu Thr Leu Leu Arg Thr Val Gly Ala Asp Tyr Arg Leu Pro 
                405                 410                 415     


Leu Thr His Gly Ala Pro Ser Glu Gln Cys Ser Thr Thr Thr His Gln 
            420                 425                 430         


Ser Ser Ser Leu Glu Arg Ser Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Ile Val Gln Ile Ser Arg Ser Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Ser Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Val Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Val Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Lys Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Glu Ala Pro Glu Ser Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Ser Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Gly Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Gln Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  206
<211>  836
<212>  PRT
<213>  Canis familiaris

<400>  206

Met Gly Asp His Ala Arg Leu Thr Arg Asp Ser Ile Phe Phe Gln Thr 
1               5                   10                  15      


Glu Gly Ala Gly Gly Gly Ala Ser Ser Pro Ala Pro Gln Lys Met Gln 
            20                  25                  30          


Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn Leu Phe 
        35                  40                  45              


Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr Thr Ser 
    50                  55                  60                  


Ser Ala Arg Val Arg Asp Glu Gly Gln Leu Ile Leu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Asn Arg Thr Trp Asp Cys Ile Leu Val Asn Pro Arg Asn Ser Gln 
                85                  90                  95      


Ser Gly Phe Arg Leu Phe Gln Leu Glu Thr Glu Ala Asp Ala Leu Val 
            100                 105                 110         


Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu Ser Ser 
        115                 120                 125             


Lys His Val Leu His Thr Glu Val Leu Gln Gln Leu Thr Asp Leu Ile 
    130                 135                 140                 


Arg Ser His Pro Ser Trp Ser Ala Ala His Leu Ala Val Glu Leu Gly 
145                 150                 155                 160 


Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala Asn Asn 
                165                 170                 175     


Arg Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys 
            180                 185                 190         


Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Ala Gln 
        195                 200                 205             


Met Asp Val Thr Asp Asn Asn Gly Glu Thr Ala Phe His Tyr Ala Val 
    210                 215                 220                 


Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Lys Asn Ala Ser 
225                 230                 235                 240 


Ala Gly Leu Asn Arg Val Asn Asn Gln Gly Gln Thr Pro Leu His Leu 
                245                 250                 255     


Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys 
            260                 265                 270         


Asn Ala Arg Cys Asn Ile Met Gly Pro Thr Gly Tyr Pro Ile His Thr 
        275                 280                 285             


Ala Met Lys Phe Cys His Lys Gly Cys Ala Glu Met Ile Ile Ser Met 
    290                 295                 300                 


Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro 
305                 310                 315                 320 


Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys Arg 
                325                 330                 335     


Gly Cys Asp Val Asn Ser Thr Ser Cys Val Gly Asn Thr Ala Leu His 
            340                 345                 350         


Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu Leu Thr 
        355                 360                 365             


Tyr Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr Pro Leu 
    370                 375                 380                 


His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala Leu Ile 
385                 390                 395                 400 


Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro 
                405                 410                 415     


Ala Ser Ile Ala Ser Lys Ile Ser Lys Leu Val Thr Arg Lys Thr Leu 
            420                 425                 430         


Leu Thr Leu Leu Arg Thr Val Gly Ala Asp Tyr Arg Leu Pro Leu Thr 
        435                 440                 445             


His Gly Ala Pro Ser Glu Gln Cys Ser Thr Thr Thr His Gln Ser Ser 
    450                 455                 460                 


Ser Leu Glu Arg Ser Gln Pro Pro Pro Ile Ser Leu Asn Asn Leu Glu 
465                 470                 475                 480 


Leu Gln Asp Ile Val Gln Ile Ser Arg Ser Arg Lys Pro Ala Phe Ile 
                485                 490                 495     


Leu Ser Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys 
            500                 505                 510         


Leu Asp Gly Gly Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile 
        515                 520                 525             


Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp 
    530                 535                 540                 


Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His 
545                 550                 555                 560 


Ser Lys Ser Met Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp 
                565                 570                 575     


Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu 
            580                 585                 590         


Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys 
        595                 600                 605             


Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala 
    610                 615                 620                 


Glu Leu His Leu Phe Arg Asn Tyr Glu Ala Pro Glu Ser Val Arg Glu 
625                 630                 635                 640 


Pro Arg Phe Ser Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ser 
                645                 650                 655     


Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr 
            660                 665                 670         


Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn 
        675                 680                 685             


Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp 
    690                 695                 700                 


Leu Ile Arg Lys Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val 
705                 710                 715                 720 


Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val 
                725                 730                 735     


Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe 
            740                 745                 750         


Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro 
        755                 760                 765             


Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly 
    770                 775                 780                 


Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu 
785                 790                 795                 800 


Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu 
                805                 810                 815     


Val Tyr Ile Tyr Glu His Arg Glu Gln Phe Gln Lys Leu Ile Gln Leu 
            820                 825                 830         


Leu Leu Ser Pro 
        835     


<210>  207
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  208
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Gln Ala Gly Trp Ser Gly Arg His Cys Arg Glu Arg Ala Ser Arg 
1               5                   10                  15      


Arg Cys Ser Pro Ser Asp Cys Gly Leu His Pro Asp Cys Leu Leu Leu 
            20                  25                  30          


Gln Gly Leu His Asp Tyr Leu Lys Phe Asn Asn Asn Ala Arg Ser Val 
        35                  40                  45              


Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu Phe Ser Pro Lys 
    50                  55                  60                  


His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg Gly Phe His Thr 
65                  70                  75                  80  


Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala His Ser Cys Ser 
                85                  90                  95      


Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His Ile Gly Ile Leu 
            100                 105                 110         


Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys Val Asn Ile Cys 
        115                 120                 125             


Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala Val Phe 
    130                 135                 140                 


Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln Phe Lys Pro Ser 
145                 150                 155                 160 


Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp Leu Lys Gln Lys 
                165                 170                 175     


Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr Ser Asp Lys Ser 
            180                 185                 190         


Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His Ile Ile Asp Lys 
        195                 200                 205             


Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr Thr Ser Ser Ile 
    210                 215                 220                 


Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser Asn His Ile Asn 
225                 230                 235                 240 


Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln Lys Glu Asn Glu 
                245                 250                 255     


His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys Val Glu Glu Gly 
            260                 265                 270         


Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr Lys Pro Gly Ser 
        275                 280                 285             


Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro Ser Ala Ile Pro 
    290                 295                 300                 


Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala Asn Phe Leu Ser 
305                 310                 315                 320 


Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly 
                325                 330                 335     


Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln Ser Glu Glu Gln 
            340                 345                 350         


Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys Asp Arg Asn Ala 
        355                 360                 365             


Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys Ile Ile Ala Arg 
    370                 375                 380                 


Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg 
385                 390                 395                 400 


Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe 
                405                 410                 415     


His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Val Lys Glu Arg 
            420                 425                 430         


Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys Asp Glu Thr Leu 
        435                 440                 445             


Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro 
    450                 455                 460                 


Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp Gly Gly Gly Thr 
465                 470                 475                 480 


Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr 
                485                 490                 495     


Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr 
            500                 505                 510         


Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp 
        515                 520                 525             


Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Ser Gln 
    530                 535                 540                 


Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr 
545                 550                 555                 560 


Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg Met Gly Ser Ala 
                565                 570                 575     


Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val Ala Ala 
            580                 585                 590         


Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe Val Phe 
        595                 600                 605             


Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His Tyr Leu Gly Gly 
    610                 615                 620                 


Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro 
625                 630                 635                 640 


Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln Asp Gly 
                645                 650                 655     


Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu Cys Lys 
            660                 665                 670         


Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu Gly Thr 
        675                 680                 685             


Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr Tyr Thr Ser Leu 
    690                 695                 700                 


Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr Glu Glu 
705                 710                 715                 720 


Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr Phe Arg 
                725                 730                 735     


Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asn 
            740                 745                 750         


Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile Glu Arg 
        755                 760                 765             


Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys 
    770                 775                 780                 


Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr Asp Met 
785                 790                 795                 800 


Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
                805                 810 


<210>  209
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  209

Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys Asp Glu 
1               5                   10                  15      


Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val 
            20                  25                  30          


Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp Gly Gly 
        35                  40                  45              


Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu 
    50                  55                  60                  


Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys Gly Val 
65                  70                  75                  80  


Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro 
                85                  90                  95      


Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe 
            100                 105                 110         


Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala 
        115                 120                 125             


Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg Met Gly 
    130                 135                 140                 


Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro Lys Val 
145                 150                 155                 160 


Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys Ala Phe 
                165                 170                 175     


Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His Tyr Leu 
            180                 185                 190         


Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala 
        195                 200                 205             


Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu His Gln 
    210                 215                 220                 


Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met His Glu 
225                 230                 235                 240 


Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val Ser Leu 
                245                 250                 255     


Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr Tyr Thr 
            260                 265                 270         


Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Thr 
        275                 280                 285             


Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp Thr Tyr 
    290                 295                 300                 


Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp Glu Ser 
305                 310                 315                 320 


Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys Tyr Ile 
                325                 330                 335     


Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln 
            340                 345                 350         


Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Thr 
        355                 360                 365             


Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    370                 375                 380 


<210>  210
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  211
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  212
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Asn 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Ser Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  213
<211>  1458
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  213

Met Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro Arg Arg 
1               5                   10                  15      


Cys Thr Glu Gly Ala Ala Ala Ala Leu Ser Pro Glu Arg Val Leu Lys 
            20                  25                  30          


Trp Gln Glu Lys Gly Ile Phe Ile Ile Gln Ser Glu Ser Leu Lys Ser 
        35                  40                  45              


Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Ser Cys Lys Gln 
    50                  55                  60                  


Pro Asn Lys Asn Met Leu Trp Lys Trp Val Ser Asn Gln His Leu Phe 
65                  70                  75                  80  


Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Leu Ser Asn Pro Glu 
                85                  90                  95      


Gln Pro Leu Gly Leu Tyr Glu Cys Asp Ser Thr His Val Ser Leu Arg 
            100                 105                 110         


Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln His Thr Val 
        115                 120                 125             


Gln Val Lys Gln Asp Asn Ile Ile Val Ala Ser Gly Lys Arg Leu His 
    130                 135                 140                 


Lys Trp Ile Ser Tyr Met Ser Asp Ser Gly Asp Ile Cys Gln His Val 
145                 150                 155                 160 


His Lys Asp Leu Tyr Thr Arg Lys Gly Asn Ala His Gly Thr Pro Cys 
                165                 170                 175     


Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys Thr Arg 
            180                 185                 190         


Glu Gly Arg Gln Asp Asp Ser Leu Trp Cys Ala Thr Thr Ser Arg Tyr 
        195                 200                 205             


Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser Ala Glu 
    210                 215                 220                 


Val Gly Cys Asp Ala Val Trp Glu Lys Asp Leu Asn Ser His Ile Cys 
225                 230                 235                 240 


Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala His Ser 
                245                 250                 255     


Ser Cys Gln Met His Gly Gly Ala Leu Leu Ser Ile Val Asp Glu Ala 
            260                 265                 270         


Glu Glu Asn Phe Ile Arg Lys Gln Val Ser Gly Glu Ala Val Glu Val 
        275                 280                 285             


Trp Thr Gly Leu Asn Gln Leu Asp Val Asn Ala Gly Trp Gln Trp Ser 
    290                 295                 300                 


Asp Gly Thr Pro Leu Ser Tyr Leu Asn Trp Ser Pro Glu Ile Ser Phe 
305                 310                 315                 320 


Glu Pro Phe Val Glu Tyr His Cys Gly Thr Phe Asn Ser Phe Met Pro 
                325                 330                 335     


Arg Ala Trp Arg Ser Arg Asn Cys Glu Ser Thr Leu Pro Tyr Ile Cys 
            340                 345                 350         


Lys Lys Tyr Leu Asn His Val Asp Asp Glu Ile Val Glu Lys Asp Ala 
        355                 360                 365             


Trp Lys Tyr Tyr Ala Thr Asp Cys Glu Pro Gly Trp Ala Pro Tyr His 
    370                 375                 380                 


Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp Asn Glu Ala 
385                 390                 395                 400 


Leu His Ser Cys Leu Ser Ser Asn Ser Thr Leu Ile Asp Ile Gly Ser 
                405                 410                 415     


Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asn Glu Asn Ala 
            420                 425                 430         


Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Thr Phe Pro Val Ser Phe 
        435                 440                 445             


Glu Trp Ser Asn Gly Ser Ser Val Ile Phe Thr Asn Trp His Thr Leu 
    450                 455                 460                 


Glu Pro Gln Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser Ala Glu 
465                 470                 475                 480 


Gln Ser Glu Gly His Trp Lys Val Thr Asp Cys Glu Glu Thr His Phe 
                485                 490                 495     


Tyr Val Cys Lys Lys Pro Gly His Val Leu Ser Asp Ala Glu Ser Gly 
            500                 505                 510         


Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys Ile Asp 
        515                 520                 525             


Thr Val Leu Arg Ser Phe Asp His Ala Ser Ser Gly Tyr Tyr Cys Pro 
    530                 535                 540                 


Pro Ala Leu Val Thr Ile Ala Asp Arg Phe Glu Gln Ala Phe Ile Thr 
545                 550                 555                 560 


Ser Leu Ile Ser Ser Val Val Asn Met Lys Asp Ser Tyr Phe Trp Ile 
                565                 570                 575     


Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys Thr Ala 
            580                 585                 590         


Gly Gln Lys Ser Glu Pro Val Gln Tyr Thr His Trp Asn Ala His Gln 
        595                 600                 605             


Pro Arg Ser Ser Gly Gly Cys Val Ala Ile Arg Gly Arg Asn Pro Ile 
    610                 615                 620                 


Gly Arg Trp Glu Val Lys Asp Cys Val His Phe Lys Ala Met Ser Leu 
625                 630                 635                 640 


Cys Lys Gln Pro Val Glu Thr Arg Glu Lys Met Glu His Glu Glu Arg 
                645                 650                 655     


Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Gln Pro Gly Leu 
            660                 665                 670         


Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met Lys Arg 
        675                 680                 685             


Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala His Leu 
    690                 695                 700                 


Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu Leu Leu 
705                 710                 715                 720 


His Pro Lys Phe Asn Arg Ser Glu Glu Arg Gln Phe Trp Ile Gly Phe 
                725                 730                 735     


Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser Asp Gly 
            740                 745                 750         


Thr Pro Val Ile Ser Ser Phe Leu Asp Asn Asn Tyr Phe Gly Glu Asp 
        755                 760                 765             


Thr Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu Pro Leu 
    770                 775                 780                 


His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg Asp Val 
785                 790                 795                 800 


Arg Pro Lys Ile Pro Ser Trp Tyr Gln Tyr Asp Ala Pro Trp Leu Phe 
                805                 810                 815     


His Gln Asp Ala Glu Tyr Leu Phe Tyr Pro His Ser Ser Glu Trp Ser 
            820                 825                 830         


Ser Phe Glu Phe Val Cys Gly Trp Leu Arg Ser Asp Ile Leu Thr Ile 
        835                 840                 845             


His Ser Ala His Glu Gln Glu Phe Ile Leu Ser Lys Ile Lys Ala Leu 
    850                 855                 860                 


Ser Lys Tyr Gly Ala Asn Trp Trp Ile Gly Leu Gln Glu Glu Thr Ala 
865                 870                 875                 880 


Asn Asp Glu Leu Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr Gln Asn 
                885                 890                 895     


Trp Asp Lys Glu Arg Asp Arg Ser Met Asn Asn Gln Ser Gln Arg Cys 
            900                 905                 910         


Ala Phe Ile Ser Ser Ile Thr Gly Leu Trp Asp Arg Glu Glu Cys Ser 
        915                 920                 925             


Val Ser Met Pro Ser Ile Cys Lys Arg Lys Thr Phe Trp Val Ile Glu 
    930                 935                 940                 


Lys Glu Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys Gly Trp 
945                 950                 955                 960 


Leu Tyr Phe Asp Tyr Lys Cys Leu Leu Val Asn Val Pro Lys Asp Pro 
                965                 970                 975     


Ser Asn Trp Lys Asn Trp Thr Gln Ala Arg Asp Phe Cys Phe Asp Glu 
            980                 985                 990         


Gly Gly Thr Leu Val Ala Ile Glu  Ser Glu Val Glu Gln  Ala Phe Ile 
        995                 1000                 1005             


Thr Met  Asn Leu Phe Gly Gln  Thr Thr Asn Val Trp  Ile Gly Leu 
    1010                 1015                 1020             


Gln Asn  Asp Asp Tyr Glu Lys  Trp Leu Asn Gly Asn  Pro Val Ala 
    1025                 1030                 1035             


Tyr Ser  Asn Trp Ser Pro Ser  Asp Ile Ile Asn Ile  Pro Ser Tyr 
    1040                 1045                 1050             


Asn Thr  Thr Ala Asp Gln Lys  Pro Ile Pro Leu Cys  Ala Leu Leu 
    1055                 1060                 1065             


Ser Ser  Asn Pro Asn Phe His  Phe Thr Gly Lys Trp  Tyr Phe Glu 
    1070                 1075                 1080             


Asp Cys  Gly Lys Glu Gly Tyr  Gly Phe Val Cys Glu  Lys Ile Gln 
    1085                 1090                 1095             


Asp Ser  Ala Gly His Glu Val  Asn Thr Ser Ile Met  Asp Pro Ile 
    1100                 1105                 1110             


Pro Asn  Thr Leu Glu Tyr Gly  Asn Arg Thr Tyr Lys  Ile Ile Asn 
    1115                 1120                 1125             


Ala Asn  Met Thr Trp Tyr Ala  Ala Ile Lys Ser Cys  Gln Leu His 
    1130                 1135                 1140             


Gly Ala  Glu Leu Val Ser Ile  Thr Asp Gln Tyr His  Gln Ser Phe 
    1145                 1150                 1155             


Leu Thr  Val Ile Leu Ser Arg  Leu Gly His Ala His  Trp Ile Gly 
    1160                 1165                 1170             


Leu Phe  Thr Ala Asp Asn Gly  Leu His Phe Asp Trp  Ser Asp Gly 
    1175                 1180                 1185             


Thr Lys  Ser Ser Phe Thr Phe  Trp Lys Asp Glu Asp  Ser Ser Phe 
    1190                 1195                 1200             


Leu Gly  Asp Cys Val Phe Ala  Asp Thr Ser Gly Arg  Trp His Ser 
    1205                 1210                 1215             


Thr Ala  Cys Glu Ser Phe Leu  Gln Gly Ala Ile Cys  His Val Pro 
    1220                 1225                 1230             


Thr Glu  Thr Arg Pro Phe Glu  His Pro Glu Leu Cys  Ser Glu Thr 
    1235                 1240                 1245             


Ser Ile  Pro Trp Ile Lys Phe  Lys Ser Asn Cys Tyr  Ser Phe Ser 
    1250                 1255                 1260             


Thr Val  Leu His Ser Ala Ser  Phe Glu Ala Ala His  Glu Phe Cys 
    1265                 1270                 1275             


Lys Lys  Glu Gly Ser Asn Leu  Leu Thr Ile Lys Asp  Glu Ala Glu 
    1280                 1285                 1290             


Asn Ser  Phe Leu Leu Glu Glu  Pro Phe Ala Phe Gly  Ala Ser Val 
    1295                 1300                 1305             


Gln Met  Val Trp Leu Asn Ala  Gln Phe Asp Asn Glu  Thr Val Lys 
    1310                 1315                 1320             


Trp Leu  Asp Gly Thr Pro Ala  Asp Gln Ser Asn Trp  Gly Ile Arg 
    1325                 1330                 1335             


Lys Pro  Asp Met Ala His Phe  Glu Pro His Gln Cys  Leu Ala Leu 
    1340                 1345                 1350             


Arg Ile  Pro Glu Gly Val Trp  Gln Leu Ser Pro Cys  Gln Lys Asn 
    1355                 1360                 1365             


Met Gly  Phe Ile Cys Lys Met  Lys Ala Asp Ile His  Thr Val Lys 
    1370                 1375                 1380             


Glu His  Pro Gly Lys Gly Pro  Ser His Ser Ile Val  Pro Leu Ala 
    1385                 1390                 1395             


Val Ala  Leu Thr Leu Val Val  Ile Leu Ala Ile Ile  Thr Leu Ser 
    1400                 1405                 1410             


Phe Tyr  Ile Tyr Lys Gln Asn  Lys Gly Phe Phe Arg  Arg Leu Ala 
    1415                 1420                 1425             


Gly Val  Gly Asn Ser Tyr Tyr  Pro Thr Thr Asn Phe  Ser Thr Ile 
    1430                 1435                 1440             


His Leu  Glu Glu Asn Ile Leu  Ile Ser Asp Leu Glu  Lys Asn Asp 
    1445                 1450                 1455             


<210>  214
<211>  412
<212>  PRT
<213>  Mus musculus

<400>  214

Met Asp Arg His Leu Cys Thr Cys Arg Glu Thr Gln Leu Arg Ser Gly 
1               5                   10                  15      


Leu Leu Leu Pro Leu Phe Leu Leu Met Met Leu Ala Asp Leu Thr Leu 
            20                  25                  30          


Pro Ala Gln Arg His Pro Pro Val Val Leu Val Pro Gly Asp Leu Gly 
        35                  40                  45              


Asn Gln Leu Glu Ala Lys Leu Asp Lys Pro Lys Val Val His Tyr Leu 
    50                  55                  60                  


Cys Ser Lys Lys Thr Asp Ser Tyr Phe Thr Leu Trp Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Leu Leu Pro Val Ile Ile Asp Cys Trp Ile Asp Asn Ile Arg Leu 
                85                  90                  95      


Val Tyr Asn Arg Thr Ser Arg Ala Thr Gln Phe Pro Asp Gly Val Asp 
            100                 105                 110         


Val Arg Val Pro Gly Phe Gly Glu Thr Phe Ser Met Glu Phe Leu Asp 
        115                 120                 125             


Pro Ser Lys Arg Asn Val Gly Ser Tyr Phe Tyr Thr Met Val Glu Ser 
    130                 135                 140                 


Leu Val Gly Trp Gly Tyr Thr Arg Gly Glu Asp Val Arg Gly Ala Pro 
145                 150                 155                 160 


Tyr Asp Trp Arg Arg Ala Pro Asn Glu Asn Gly Pro Tyr Phe Leu Ala 
                165                 170                 175     


Leu Arg Glu Met Ile Glu Glu Met Tyr Gln Met Tyr Gly Gly Pro Val 
            180                 185                 190         


Val Leu Val Ala His Ser Met Gly Asn Val Tyr Met Leu Tyr Phe Leu 
        195                 200                 205             


Gln Arg Gln Pro Gln Val Trp Lys Asp Lys Tyr Ile His Ala Phe Val 
    210                 215                 220                 


Ser Leu Gly Ala Pro Trp Gly Gly Val Ala Lys Thr Leu Arg Val Leu 
225                 230                 235                 240 


Ala Ser Gly Asp Asn Asn Arg Ile Pro Val Ile Gly Pro Leu Lys Ile 
                245                 250                 255     


Arg Glu Gln Gln Arg Ser Ala Val Ser Thr Ser Trp Leu Leu Pro Tyr 
            260                 265                 270         


Asn His Thr Trp Ser His Glu Lys Val Phe Val Tyr Thr Pro Thr Thr 
        275                 280                 285             


Asn Tyr Thr Leu Arg Asp Tyr His Arg Phe Phe Arg Asp Ile Gly Phe 
    290                 295                 300                 


Glu Asp Gly Trp Phe Met Arg Gln Asp Thr Glu Gly Leu Val Glu Ala 
305                 310                 315                 320 


Met Thr Pro Pro Gly Val Glu Leu His Cys Leu Tyr Gly Thr Gly Val 
                325                 330                 335     


Pro Thr Pro Asn Ser Phe Tyr Tyr Glu Ser Phe Pro Asp Arg Asp Pro 
            340                 345                 350         


Lys Ile Cys Phe Gly Asp Gly Asp Gly Thr Val Asn Leu Glu Ser Val 
        355                 360                 365             


Leu Gln Cys Gln Ala Trp Gln Ser Arg Gln Glu His Arg Val Ser Leu 
    370                 375                 380                 


Gln Glu Leu Pro Gly Ser Glu His Ile Glu Met Leu Ala Asn Ala Thr 
385                 390                 395                 400 


Thr Leu Ala Tyr Leu Lys Arg Val Leu Leu Glu Pro 
                405                 410         


<210>  215
<211>  485
<212>  PRT
<213>  Mus musculus

<400>  215

Met Ile Met Leu Leu Met Val Gly Met Leu Met Ala Pro Cys Val Gly 
1               5                   10                  15      


Ala His Ala Leu Asp Thr Pro Asn Pro Gln Glu Leu Pro Pro Gly Leu 
            20                  25                  30          


Ser Lys Asn Ile Asn Ile Thr Phe Phe Asn Gly Val Phe Lys Asn Val 
        35                  40                  45              


Glu Ser Val Ala Glu Ile Phe Asp Cys Leu Gly Ser His Phe Thr Trp 
    50                  55                  60                  


Leu Gln Ala Val Phe Thr Asn Phe Pro Leu Leu Leu Gln Phe Val Asn 
65                  70                  75                  80  


Ser Met Arg Cys Val Thr Gly Leu Cys Pro Arg Asp Phe Glu Asp Tyr 
                85                  90                  95      


Gly Cys Ala Cys Arg Phe Glu Met Glu Gly Met Pro Val Asp Glu Ser 
            100                 105                 110         


Asp Ile Cys Cys Phe Gln His Arg Arg Cys Tyr Glu Glu Ala Val Glu 
        115                 120                 125             


Met Asp Cys Leu Gln Asp Pro Ala Lys Leu Ser Ala Asp Val Asp Cys 
    130                 135                 140                 


Thr Asn Lys Gln Ile Thr Cys Glu Ser Glu Asp Pro Cys Glu Arg Leu 
145                 150                 155                 160 


Leu Cys Thr Cys Asp Lys Ala Ala Val Glu Cys Leu Ala Gln Ser Gly 
                165                 170                 175     


Ile Asn Ser Ser Leu Asn Phe Leu Asp Ala Ser Phe Cys Leu Pro Gln 
            180                 185                 190         


Thr Pro Glu Thr Thr Ser Gly Lys Ala Ala Thr Leu Leu Pro Arg Gly 
        195                 200                 205             


Ile Pro Glu Lys Pro Thr Asp Thr Ser Gln Ile Ala Leu Ser Gly Glu 
    210                 215                 220                 


Val Ala Gly Glu Val Arg Ala Asp Thr Leu Thr Thr Leu Ser Arg Thr 
225                 230                 235                 240 


Lys Ser Val Gln Asp Leu Gln Asp Thr Gln Ala Ser Arg Thr Thr Ser 
                245                 250                 255     


Ser Pro Gly Ser Ala Glu Ile Ile Ala Leu Ala Lys Gly Thr Thr His 
            260                 265                 270         


Ser Ala Gly Ile Lys Pro Leu Arg Leu Gly Val Ser Ser Val Asp Asn 
        275                 280                 285             


Gly Ser Gln Glu Ala Ala Gly Lys Ala Cys Asp Arg Leu Ala Phe Val 
    290                 295                 300                 


His Leu Gly Asp Gly Asp Ser Met Thr Ala Met Leu Gln Leu Gly Glu 
305                 310                 315                 320 


Met Leu Phe Cys Leu Thr Ser His Cys Pro Glu Glu Phe Glu Thr Tyr 
                325                 330                 335     


Gly Cys Tyr Cys Gly Arg Glu Gly Arg Gly Glu Pro Arg Asp Thr Leu 
            340                 345                 350         


Asp Arg Cys Cys Leu Ser His His Cys Cys Leu Glu Gln Met Arg Gln 
        355                 360                 365             


Val Gly Cys Leu His Gly Arg Arg Ser Gln Ser Ser Val Val Cys Glu 
    370                 375                 380                 


Asp His Met Ala Lys Cys Val Gly Gln Ser Leu Cys Glu Lys Leu Leu 
385                 390                 395                 400 


Cys Ala Cys Asp Gln Met Ala Ala Glu Cys Met Ala Ser Ala Phe Phe 
                405                 410                 415     


Asn Gln Ser Leu Lys Ser Pro Asp Gly Ala Glu Cys Gln Gly Glu Pro 
            420                 425                 430         


Val Ser Cys Glu Asp Gly Met Leu Gln Gly Thr Leu Ala Ser Ser Val 
        435                 440                 445             


Asp Ser Ser Ser Glu Glu Asn Ser Glu Glu Ala Pro Pro Gln Met Glu 
    450                 455                 460                 


Arg Leu Arg Arg Phe Leu Glu Lys Pro Pro Gly Pro Leu Gly Ala Arg 
465                 470                 475                 480 


Pro Leu Gly Gly Lys 
                485 


<210>  216
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  217
<211>  195
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  217

Met Lys Leu Ala Ser Gly Phe Leu Val Leu Trp Leu Ser Leu Gly Gly 
1               5                   10                  15      


Gly Leu Ala Gln Ser Asp Thr Ser Pro Asp Thr Glu Glu Ser Tyr Ser 
            20                  25                  30          


Asp Trp Gly Leu Arg His Leu Arg Gly Ser Phe Glu Ser Val Asn Ser 
        35                  40                  45              


Tyr Phe Asp Ser Phe Leu Glu Leu Leu Gly Gly Lys Asn Gly Val Cys 
    50                  55                  60                  


Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr 
65                  70                  75                  80  


Lys Pro Gln Glu Pro Asn Gly Cys Gly Ser Tyr Phe Leu Gly Leu Lys 
                85                  90                  95      


Val Pro Glu Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys 
            100                 105                 110         


Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg 
        115                 120                 125             


Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu 
    130                 135                 140                 


Lys Arg Ser Leu Gly Phe Val Ser Lys Val Glu Ala Ala Cys Asp Ser 
145                 150                 155                 160 


Leu Val Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro 
                165                 170                 175     


Phe Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys 
            180                 185                 190         


Glu Glu Leu 
        195 


<210>  218
<211>  465
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  218

Met Val Ser Ser Gln Lys Leu Glu Lys Pro Ile Glu Met Gly Ser Ser 
1               5                   10                  15      


Glu Pro Leu Pro Ile Ala Asp Gly Asp Arg Arg Arg Lys Lys Lys Arg 
            20                  25                  30          


Arg Gly Arg Ala Thr Asp Ser Leu Pro Gly Lys Phe Glu Asp Met Tyr 
        35                  40                  45              


Lys Leu Thr Ser Glu Leu Leu Gly Glu Gly Ala Tyr Ala Lys Val Gln 
    50                  55                  60                  


Gly Ala Val Ser Leu Gln Asn Gly Lys Glu Tyr Ala Val Lys Ile Ile 
65                  70                  75                  80  


Glu Lys Gln Ala Gly His Ser Arg Ser Arg Val Phe Arg Glu Val Glu 
                85                  90                  95      


Thr Leu Tyr Gln Cys Gln Gly Asn Lys Asn Ile Leu Glu Leu Ile Glu 
            100                 105                 110         


Phe Phe Glu Asp Asp Thr Arg Phe Tyr Leu Val Phe Glu Lys Leu Gln 
        115                 120                 125             


Gly Gly Ser Ile Leu Ala His Ile Gln Lys Gln Lys His Phe Asn Glu 
    130                 135                 140                 


Arg Glu Ala Ser Arg Val Val Arg Asp Val Ala Ala Ala Leu Asp Phe 
145                 150                 155                 160 


Leu His Thr Lys Asp Lys Val Ser Leu Cys His Leu Gly Trp Ser Ala 
                165                 170                 175     


Met Ala Pro Ser Gly Leu Thr Ala Ala Pro Thr Ser Leu Gly Ser Ser 
            180                 185                 190         


Asp Pro Pro Thr Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Ile Ala 
        195                 200                 205             


His Arg Asp Leu Lys Pro Glu Asn Ile Leu Cys Glu Ser Pro Glu Lys 
    210                 215                 220                 


Val Ser Pro Val Lys Ile Cys Asp Phe Asp Leu Gly Ser Gly Met Lys 
225                 230                 235                 240 


Leu Asn Asn Ser Cys Thr Pro Ile Thr Thr Pro Glu Leu Thr Thr Pro 
                245                 250                 255     


Cys Gly Ser Ala Glu Tyr Met Ala Pro Glu Val Val Glu Val Phe Thr 
            260                 265                 270         


Asp Gln Ala Thr Phe Tyr Asp Lys Arg Cys Asp Leu Trp Ser Leu Gly 
        275                 280                 285             


Val Val Leu Tyr Ile Met Leu Ser Gly Tyr Pro Pro Phe Val Gly His 
    290                 295                 300                 


Cys Gly Ala Asp Cys Gly Trp Asp Arg Gly Glu Val Cys Arg Val Cys 
305                 310                 315                 320 


Gln Asn Lys Leu Phe Glu Ser Ile Gln Glu Gly Lys Tyr Glu Phe Pro 
                325                 330                 335     


Asp Lys Asp Trp Ala His Ile Ser Ser Glu Ala Lys Asp Leu Ile Ser 
            340                 345                 350         


Lys Leu Leu Val Arg Asp Ala Lys Gln Arg Leu Ser Ala Ala Gln Val 
        355                 360                 365             


Leu Gln His Pro Trp Val Gln Gly Gln Ala Pro Glu Lys Gly Leu Pro 
    370                 375                 380                 


Thr Pro Gln Val Leu Gln Arg Asn Ser Ser Thr Met Asp Leu Thr Leu 
385                 390                 395                 400 


Phe Ala Ala Glu Ala Ile Ala Leu Asn Arg Gln Leu Ser Gln His Glu 
                405                 410                 415     


Glu Asn Glu Leu Ala Glu Glu Pro Glu Ala Leu Ala Asp Gly Leu Cys 
            420                 425                 430         


Ser Met Lys Leu Ser Pro Pro Cys Lys Ser Arg Leu Ala Arg Arg Arg 
        435                 440                 445             


Ala Leu Ala Gln Ala Gly Arg Gly Glu Asp Arg Ser Pro Pro Thr Ala 
    450                 455                 460                 


Leu 
465 


<210>  219
<211>  229
<212>  PRT
<213>  Mus musculus

<400>  219

Met Ser Gln Gly Asp Ser Asn Pro Ala Ala Ile Pro His Ala Ala Glu 
1               5                   10                  15      


Asp Ile Gln Gly Asp Asp Arg Trp Met Ser Gln His Asn Arg Phe Val 
            20                  25                  30          


Leu Asp Cys Lys Asp Lys Glu Pro Asp Val Leu Phe Val Gly Asp Ser 
        35                  40                  45              


Met Val Gln Leu Met Gln Gln Tyr Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Thr Thr Arg His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Lys Asn Gly Glu Leu Glu Asn Ile Lys Pro Lys 
                85                  90                  95      


Val Ile Val Val Trp Val Gly Thr Asn Asn His Glu Asn Thr Ala Glu 
            100                 105                 110         


Glu Val Ala Gly Gly Ile Glu Ala Ile Val Gln Leu Ile Asn Thr Arg 
        115                 120                 125             


Gln Pro Gln Ala Lys Ile Ile Val Leu Gly Leu Leu Pro Arg Gly Glu 
    130                 135                 140                 


Lys Pro Asn Pro Leu Arg Gln Lys Asn Ala Lys Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Val Ser Leu Pro Lys Leu Ala Asn Val Gln Leu Leu Asp Ile Asp 
                165                 170                 175     


Gly Gly Phe Val His Ser Asp Gly Ala Ile Ser Cys His Asp Met Phe 
            180                 185                 190         


Asp Phe Leu His Leu Thr Gly Gly Gly Tyr Ala Lys Ile Cys Lys Pro 
        195                 200                 205             


Leu His Glu Leu Ile Met Gln Leu Leu Glu Glu Thr Pro Glu Glu Lys 
    210                 215                 220                 


Gln Thr Thr Ile Ala 
225                 


<210>  220
<211>  589
<212>  PRT
<213>  Rattus norvegicus

<400>  220

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Thr Asn Ser Thr Lys 
                325                 330                 335     


Asn Ser Ser Ala Ile Thr Ser Pro Lys Gly Ser Leu Pro Pro Ala Ala 
            340                 345                 350         


Leu Glu Ser Ser Asp Ser Thr Asn Thr Thr Ile Glu Asp Glu Asp Ala 
        355                 360                 365             


Lys Ala Pro Arg Ile Ser Asp Ile Leu Asn Ser Val Arg Arg Gly Cys 
    370                 375                 380                 


Gly Thr Pro Glu Ala Glu Gly Pro Leu Ser Val Gly Pro Pro Pro Cys 
385                 390                 395                 400 


Leu Ser Pro Gly Leu Leu Gly Pro Leu Pro Thr Pro Ser Pro Arg Ile 
                405                 410                 415     


Ser Asp Ile Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro Glu Ala 
            420                 425                 430         


Glu Gly Leu Pro Pro Val Gly Pro Pro Pro Cys Pro Ser Pro Thr Leu 
        435                 440                 445             


Pro Gly Pro Leu Pro Thr Pro Ser Arg Lys Gln Glu Ile Ile Lys Thr 
    450                 455                 460                 


Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr 
465                 470                 475                 480 


Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu 
                485                 490                 495     


Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn 
            500                 505                 510         


Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro 
        515                 520                 525             


His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg 
    530                 535                 540                 


Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser 
545                 550                 555                 560 


Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val 
                565                 570                 575     


His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
            580                 585                 


<210>  221
<211>  503
<212>  PRT
<213>  Rattus norvegicus

<400>  221

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Thr Asn Ser Thr Lys 
                325                 330                 335     


Asn Ser Ser Ala Ile Thr Ser Pro Lys Gly Ser Leu Pro Pro Ala Ala 
            340                 345                 350         


Leu Glu Ser Ser Asp Ser Thr Asn Thr Thr Ile Glu Asp Glu Asp Ala 
        355                 360                 365             


Lys Ala Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu 
    370                 375                 380                 


Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro 
385                 390                 395                 400 


Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly 
                405                 410                 415     


Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser 
            420                 425                 430         


Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile Gly 
        435                 440                 445             


Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile Asp 
    450                 455                 460                 


Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val Trp 
465                 470                 475                 480 


His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly 
                485                 490                 495     


Ala Pro Val Ala Pro Leu Gln 
            500             


<210>  222
<211>  542
<212>  PRT
<213>  Rattus norvegicus

<400>  222

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
305                 310                 315                 320 


Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ser Ala Ile Thr Ser Pro 
        355                 360                 365             


Lys Gly Ser Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
    370                 375                 380                 


His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Thr Asn Thr 
385                 390                 395                 400 


Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile Lys 
                405                 410                 415     


Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala 
            420                 425                 430         


Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala 
        435                 440                 445             


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
    450                 455                 460                 


Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn 
465                 470                 475                 480 


Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile 
                485                 490                 495     


Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln 
            500                 505                 510         


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
        515                 520                 525             


Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
    530                 535                 540         


<210>  223
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Val Ser Ser Gln Lys Leu Glu Lys Pro Ile Glu Met Gly Ser Ser 
1               5                   10                  15      


Glu Pro Leu Pro Ile Ala Asp Gly Asp Arg Arg Arg Lys Lys Lys Arg 
            20                  25                  30          


Arg Gly Arg Ala Thr Asp Ser Leu Pro Gly Lys Phe Glu Asp Met Tyr 
        35                  40                  45              


Lys Leu Thr Ser Glu Leu Leu Gly Glu Gly Ala Tyr Ala Lys Val Gln 
    50                  55                  60                  


Gly Ala Val Ser Leu Gln Asn Gly Lys Glu Tyr Ala Val Lys Ile Ile 
65                  70                  75                  80  


Glu Lys Gln Ala Gly His Ser Arg Ser Arg Val Phe Arg Glu Val Glu 
                85                  90                  95      


Thr Leu Tyr Gln Cys Gln Gly Asn Lys Asn Ile Leu Glu Leu Ile Glu 
            100                 105                 110         


Phe Phe Glu Asp Asp Thr Arg Phe Tyr Leu Val Phe Glu Lys Leu Gln 
        115                 120                 125             


Gly Gly Ser Ile Leu Ala His Ile Gln Lys Gln Lys His Phe Asn Glu 
    130                 135                 140                 


Arg Glu Ala Ser Arg Val Val Arg Asp Val Ala Ala Ala Leu Asp Phe 
145                 150                 155                 160 


Leu His Thr Lys Gly Ile Ala His Arg Asp Leu Lys Pro Glu Asn Ile 
                165                 170                 175     


Leu Cys Glu Ser Pro Glu Lys Val Ser Pro Val Lys Ile Cys Asp Phe 
            180                 185                 190         


Asp Leu Gly Ser Gly Met Lys Leu Asn Asn Ser Cys Thr Pro Ile Thr 
        195                 200                 205             


Thr Pro Glu Leu Thr Thr Pro Cys Gly Ser Ala Glu Tyr Met Ala Pro 
    210                 215                 220                 


Glu Val Val Glu Val Phe Thr Asp Gln Ala Thr Phe Tyr Asp Lys Arg 
225                 230                 235                 240 


Cys Asp Leu Trp Ser Leu Gly Val Val Leu Tyr Ile Met Leu Ser Gly 
                245                 250                 255     


Tyr Pro Pro Phe Val Gly His Cys Gly Ala Asp Cys Gly Trp Asp Arg 
            260                 265                 270         


Gly Glu Val Cys Arg Val Cys Gln Asn Lys Leu Phe Glu Ser Ile Gln 
        275                 280                 285             


Glu Gly Lys Tyr Glu Phe Pro Asp Lys Asp Trp Ala His Ile Ser Ser 
    290                 295                 300                 


Glu Ala Lys Asp Leu Ile Ser Lys Leu Leu Val Arg Asp Ala Lys Gln 
305                 310                 315                 320 


Arg Leu Ser Ala Ala Gln Val Leu Gln His Pro Trp Val Gln Gly Glu 
                325                 330                 335     


Gln Gln His Asn Gly Pro Asp Ala Leu Arg Ser 
            340                 345         


<210>  224
<211>  232
<212>  PRT
<213>  Mus musculus

<400>  224

Met Ser Gly Glu Gly Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln 
1               5                   10                  15      


Asp Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val 
            20                  25                  30          


Ala Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser 
        35                  40                  45              


Leu Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Ser Thr Gln His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys 
                85                  90                  95      


Ile Val Val Val Trp Val Gly Thr Asn Asn His Ser His Thr Ala Glu 
            100                 105                 110         


Gln Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Lys Leu 
        115                 120                 125             


Gln Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln 
    130                 135                 140                 


His Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Val 
145                 150                 155                 160 


Arg Ala Ala Leu Ala Gly Tyr Pro Arg Ala His Phe Leu Asp Ala Asp 
                165                 170                 175     


Pro Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr 
            180                 185                 190         


Asp Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala 
        195                 200                 205             


Leu His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly 
    210                 215                 220                 


Ile Pro Leu Pro Glu Thr Ala Ser 
225                 230         


<210>  225
<211>  231
<212>  PRT
<213>  Pongo abelii

<400>  225

Met Ser Gly Glu Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln Asp 
1               5                   10                  15      


Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val Ala 
            20                  25                  30          


Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser Leu 
        35                  40                  45              


Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser Pro 
    50                  55                  60                  


Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Gly Thr Gln His Val 
65                  70                  75                  80  


Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys Ile 
                85                  90                  95      


Val Val Val Trp Val Gly Thr Asn Asn His Gly His Thr Ala Glu Gln 
            100                 105                 110         


Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Glu Arg Gln 
        115                 120                 125             


Pro Gln Ala Arg Val Val Val Leu Asp Leu Leu Pro Arg Gly Gln His 
    130                 135                 140                 


Pro Asn Pro Leu Arg Glu Lys Asn Gln Arg Val Asn Glu Leu Val Arg 
145                 150                 155                 160 


Ala Ala Leu Ala Gly His Pro Arg Ala His Phe Leu Asp Ala Asp Pro 
                165                 170                 175     


Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr Asp 
            180                 185                 190         


Tyr Leu His Leu Ser Arg Leu Gly Tyr Ala Pro Val Cys Arg Ala Leu 
        195                 200                 205             


His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly Ala 
    210                 215                 220                 


Pro Leu Leu Asp Pro Ala Pro 
225                 230     


<210>  226
<211>  229
<212>  PRT
<213>  Pongo abelii

<400>  226

Met Ser Gln Gly Asp Ser Asn Pro Ala Ala Ile Pro His Ala Ala Glu 
1               5                   10                  15      


Asp Ile Gln Gly Asp Asp Arg Trp Met Ser Gln His Asn Arg Phe Val 
            20                  25                  30          


Leu Asp Cys Lys Asp Lys Glu Pro Asp Val Leu Phe Val Gly Asp Ser 
        35                  40                  45              


Met Val Gln Leu Met Gln Gln Tyr Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Thr Thr Arg His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Lys Asn Gly Glu Leu Glu Asn Ile Lys Pro Lys 
                85                  90                  95      


Val Ile Val Val Trp Val Gly Thr Asn Asn His Glu Asn Thr Ala Glu 
            100                 105                 110         


Glu Val Ala Gly Gly Ile Glu Ala Ile Val Gln Leu Ile Asn Thr Arg 
        115                 120                 125             


Gln Pro Gln Ala Lys Ile Ile Val Leu Gly Leu Leu Pro Arg Gly Glu 
    130                 135                 140                 


Lys Pro Asn Pro Leu Arg Gln Lys Asn Ala Lys Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Val Ser Leu Pro Lys Leu Ala Asn Val Gln Leu Leu Asp Thr Asp 
                165                 170                 175     


Gly Gly Phe Val His Ser Asp Gly Ala Ile Ser Cys His Asp Met Phe 
            180                 185                 190         


Asp Phe Leu His Leu Thr Gly Gly Gly Tyr Ala Lys Ile Cys Lys Pro 
        195                 200                 205             


Leu His Glu Leu Ile Met Gln Leu Leu Glu Glu Thr Pro Glu Glu Lys 
    210                 215                 220                 


Gln Thr Thr Ile Ala 
225                 


<210>  227
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Ser Gln Gly Asp Ser Asn Pro Ala Ala Ile Pro His Ala Ala Glu 
1               5                   10                  15      


Asp Ile Gln Gly Asp Asp Arg Trp Met Ser Gln His Asn Arg Phe Val 
            20                  25                  30          


Leu Asp Cys Lys Asp Lys Glu Pro Asp Val Leu Phe Val Gly Asp Ser 
        35                  40                  45              


Met Val Gln Leu Met Gln Gln Tyr Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Thr Thr Arg His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Lys Asn Gly Glu Leu Glu Asn Ile Lys Pro Lys 
                85                  90                  95      


Val Ile Val Val Trp Val Gly Thr Asn Asn His Glu Asn Thr Ala Glu 
            100                 105                 110         


Glu Val Ala Gly Gly Ile Glu Ala Ile Val Gln Leu Ile Asn Thr Arg 
        115                 120                 125             


Gln Pro Gln Ala Lys Ile Ile Val Leu Gly Leu Leu Pro Arg Gly Glu 
    130                 135                 140                 


Lys Pro Asn Pro Leu Arg Gln Lys Asn Ala Lys Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Val Ser Leu Pro Lys Leu Ala Asn Val Gln Leu Leu Asp Thr Asp 
                165                 170                 175     


Gly Gly Phe Val His Ser Asp Gly Ala Ile Ser Cys His Asp Met Phe 
            180                 185                 190         


Asp Phe Leu His Leu Thr Gly Gly Gly Tyr Ala Lys Ile Cys Lys Pro 
        195                 200                 205             


Leu His Glu Leu Ile Met Gln Leu Leu Glu Glu Thr Pro Glu Glu Lys 
    210                 215                 220                 


Gln Thr Thr Ile Ala 
225                 


<210>  228
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Ser Gly Glu Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln Asp 
1               5                   10                  15      


Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val Ala 
            20                  25                  30          


Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser Leu 
        35                  40                  45              


Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser Pro 
    50                  55                  60                  


Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Gly Thr Gln His Val 
65                  70                  75                  80  


Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys Ile 
                85                  90                  95      


Val Val Val Trp Val Gly Thr Asn Asn His Gly His Thr Ala Glu Gln 
            100                 105                 110         


Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Glu Arg Gln 
        115                 120                 125             


Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln His 
    130                 135                 140                 


Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Val Arg 
145                 150                 155                 160 


Ala Ala Leu Ala Gly His Pro Arg Ala His Phe Leu Asp Ala Asp Pro 
                165                 170                 175     


Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr Asp 
            180                 185                 190         


Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala Leu 
        195                 200                 205             


His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly Ala 
    210                 215                 220                 


Pro Leu Leu Glu Pro Ala Pro 
225                 230     


<210>  229
<211>  229
<212>  PRT
<213>  Bos taurus

<400>  229

Met Ser Gln Gly Asp Ser Asn Pro Ala Ala Ile Pro His Ala Ala Glu 
1               5                   10                  15      


Asp Ile Gln Gly Asp Asp Arg Trp Met Ser Gln His Asn Arg Phe Val 
            20                  25                  30          


Leu Asp Cys Lys Asp Lys Glu Pro Asp Val Leu Phe Val Gly Asp Ser 
        35                  40                  45              


Met Val Gln Leu Met Gln Gln Tyr Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Thr Thr Arg His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Lys Asn Gly Glu Leu Glu Asn Ile Lys Pro Lys 
                85                  90                  95      


Val Ile Val Val Trp Val Gly Thr Asn Asn His Glu Asn Thr Ala Glu 
            100                 105                 110         


Glu Val Ala Gly Gly Ile Glu Ala Ile Val Gln Leu Ile Asn Thr Arg 
        115                 120                 125             


Gln Pro Gln Ala Lys Ile Ile Val Leu Gly Leu Leu Pro Arg Gly Glu 
    130                 135                 140                 


Lys Pro Asn Pro Leu Arg Gln Lys Asn Ala Lys Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Val Ser Leu Pro Lys Leu Ala Asn Val Gln Leu Leu Asp Thr Asp 
                165                 170                 175     


Gly Gly Phe Val His Ser Asp Gly Ala Ile Ser Cys His Asp Met Phe 
            180                 185                 190         


Asp Phe Leu His Leu Thr Gly Gly Gly Tyr Ala Lys Ile Cys Lys Pro 
        195                 200                 205             


Leu His Glu Leu Ile Met Gln Leu Leu Glu Glu Thr Pro Glu Glu Lys 
    210                 215                 220                 


Gln Thr Thr Ile Ala 
225                 


<210>  230
<211>  232
<212>  PRT
<213>  Rattus norvegicus

<400>  230

Met Ser Gly Glu Gly Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln 
1               5                   10                  15      


Asp Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val 
            20                  25                  30          


Ala Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser 
        35                  40                  45              


Leu Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Ser Thr Gln His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys 
                85                  90                  95      


Ile Val Val Val Trp Val Gly Thr Asn Asn His Ser His Thr Ala Glu 
            100                 105                 110         


Gln Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Lys Leu 
        115                 120                 125             


Gln Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln 
    130                 135                 140                 


His Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Val 
145                 150                 155                 160 


Arg Ala Ala Leu Ala Gly Tyr Pro Arg Ala His Phe Leu Asp Ala Asp 
                165                 170                 175     


Pro Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr 
            180                 185                 190         


Asp Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala 
        195                 200                 205             


Leu His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly 
    210                 215                 220                 


Ile Pro Leu Pro Glu Thr Ala Pro 
225                 230         


<210>  231
<211>  229
<212>  PRT
<213>  Rattus norvegicus

<400>  231

Met Ser Gln Gly Asp Ser Asn Pro Ala Ala Ile Pro His Ala Ala Glu 
1               5                   10                  15      


Asp Ile Gln Gly Asp Asp Arg Trp Met Ser Gln His Asn Arg Phe Val 
            20                  25                  30          


Leu Asp Cys Lys Asp Lys Glu Pro Asp Val Leu Phe Val Gly Asp Ser 
        35                  40                  45              


Met Val Gln Leu Met Gln Gln Tyr Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Thr Thr Arg His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Lys Asn Gly Glu Leu Glu Asn Ile Lys Pro Lys 
                85                  90                  95      


Val Ile Val Val Trp Val Gly Thr Asn Asn His Glu Asn Thr Ala Glu 
            100                 105                 110         


Glu Val Ala Gly Gly Ile Glu Ala Ile Val Gln Leu Ile Asn Thr Arg 
        115                 120                 125             


Gln Pro Gln Ala Lys Ile Ile Val Leu Gly Leu Leu Pro Arg Gly Glu 
    130                 135                 140                 


Lys Pro Asn Pro Leu Arg Gln Lys Asn Ala Lys Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Val Ser Leu Pro Lys Leu Ala Asn Val Gln Leu Leu Asp Ile Asp 
                165                 170                 175     


Gly Gly Phe Val His Ser Asp Gly Ala Ile Ser Cys His Asp Met Phe 
            180                 185                 190         


Asp Phe Leu His Leu Thr Gly Gly Gly Tyr Ala Lys Ile Cys Lys Pro 
        195                 200                 205             


Leu His Glu Leu Ile Met Gln Leu Leu Glu Glu Thr Pro Glu Glu Lys 
    210                 215                 220                 


Gln Thr Thr Ile Ala 
225                 


<210>  232
<211>  232
<212>  PRT
<213>  Bos taurus

<400>  232

Met Ser Gly Asp Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln Asp 
1               5                   10                  15      


Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val Ala 
            20                  25                  30          


Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser Leu 
        35                  40                  45              


Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser Pro 
    50                  55                  60                  


Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Ser Thr Gln His Val 
65                  70                  75                  80  


Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys Ile 
                85                  90                  95      


Val Val Val Trp Val Gly Thr Asn Asn His Gly His Thr Ala Glu Gln 
            100                 105                 110         


Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Glu Arg Gln 
        115                 120                 125             


Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln His 
    130                 135                 140                 


Pro Asn Pro Leu Arg Glu Lys Asn Arg Arg Val Asn Glu Leu Val Arg 
145                 150                 155                 160 


Ala Ala Leu Ala Gly His Pro Arg Ala His Phe Leu Asp Ala Asp Pro 
                165                 170                 175     


Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr Asp 
            180                 185                 190         


Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala Leu 
        195                 200                 205             


His Ser Leu Leu Leu Arg Leu Leu Thr Gln Asp Gln Gly Gln Gly Gly 
    210                 215                 220                 


Ala Pro Leu Pro Glu Pro Ser Pro 
225                 230         


<210>  233
<211>  224
<212>  PRT
<213>  Rattus norvegicus

<400>  233

Met Pro Gly Gly Leu Leu Leu Gly Asp Glu Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Ile Gly His Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Phe 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Gly Ala Ala Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Lys Asp Arg Asp Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Ile Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Asp Ser Leu Gln Leu Thr Ala Ser Asn Pro Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Lys Gly Glu Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Leu Pro Glu Glu Glu Ala Lys Gln Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  234
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Ser Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp 
    


<210>  235
<211>  384
<212>  PRT
<213>  Mus musculus

<400>  235

Met Ala Gln Ala Ala Arg Leu Ser Trp Val Leu Val Ser Ser Arg Cys 
1               5                   10                  15      


Ala Leu Thr Glu Gly Leu Leu Thr Arg Pro Trp Gln Pro Leu Ser Ala 
            20                  25                  30          


Gln Ser Arg Ala Gly Phe Thr Arg Val Ala Ala Gly Ser Arg Gly Ala 
        35                  40                  45              


Ala Val Arg Lys Gly Ser Pro Arg Leu Leu Gly Ala Ala Ala Leu Ala 
    50                  55                  60                  


Leu Gly Gly Ala Leu Gly Leu Tyr His Thr Val Arg Trp His Gln Arg 
65                  70                  75                  80  


Ser Gln Asp Leu Arg Ala Glu Arg Ser Ala Ala Gln Leu Pro Leu Ser 
                85                  90                  95      


Asn Ser Leu Gln Leu Thr Leu Tyr Gln Tyr Lys Thr Cys Pro Phe Cys 
            100                 105                 110         


Ser Lys Val Arg Ala Phe Leu Asp Phe His Ser Leu Pro Tyr Gln Val 
        115                 120                 125             


Val Glu Val Asn Pro Val Arg Arg Thr Glu Ile Lys Phe Ser Ser Tyr 
    130                 135                 140                 


Arg Lys Val Pro Ile Leu Val Ala Gln Glu Gly Asp Ser Leu Gln Gln 
145                 150                 155                 160 


Leu Asn Asp Ser Ser Val Ile Ile Ser Ala Leu Lys Thr Tyr Leu Val 
                165                 170                 175     


Ser Gly Gln Pro Leu Glu Glu Val Ile Thr Tyr Tyr Pro Pro Met Lys 
            180                 185                 190         


Ala Met Asn Asp Gln Gly Lys Glu Val Thr Glu Phe Cys Asn Lys Tyr 
        195                 200                 205             


Trp Pro Met Leu Asp Glu Lys Glu Ala Gln Gln Met Tyr Gly Gly Lys 
    210                 215                 220                 


Glu Ala Arg Thr Glu Glu Met Lys Trp Arg Gln Trp Ala Asp Asp Trp 
225                 230                 235                 240 


Leu Val His Leu Ile Ser Pro Asn Val Tyr Arg Thr Pro Ala Glu Ala 
                245                 250                 255     


Leu Ala Ser Phe Asp Tyr Ile Val Arg Glu Gly Lys Phe Gly Ala Val 
            260                 265                 270         


Glu Ala Ala Met Ala Lys Tyr Val Gly Ala Ala Ala Met Tyr Leu Ile 
        275                 280                 285             


Ser Lys Arg Leu Lys Ser Arg His His Leu Gln Asp Asp Val Arg Val 
    290                 295                 300                 


Asp Leu Tyr Glu Ala Ala Asn Lys Trp Val Thr Ala Val Gly Lys Asp 
305                 310                 315                 320 


Arg Pro Phe Met Gly Gly Gln Lys Pro Asn Leu Ala Asp Leu Ala Val 
                325                 330                 335     


Tyr Gly Val Leu Arg Val Met Glu Gly Leu Glu Ala Phe Asp Asp Leu 
            340                 345                 350         


Met Arg His Ser His Ile Gln Pro Trp Tyr Leu Arg Met Glu Arg Ala 
        355                 360                 365             


Ile Glu Glu Ala Pro Ser Val His His Val Asn Pro Ser Cys Lys Asp 
    370                 375                 380                 


<210>  236
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  236

Met Lys Leu Leu Cys Gly Phe Phe Leu Leu Trp Leu Gly Leu Val Gly 
1               5                   10                  15      


Asn Leu Ala Gln Ser Asp Pro Ser Pro Lys Glu Glu Glu Ser Tyr Ser 
            20                  25                  30          


Asp Trp Gly Leu Arg Gln Leu Arg Gly Ser Phe Glu Ser Val Asn Ser 
        35                  40                  45              


Tyr Val Asp Ser Phe Met Glu Leu Leu Gly Gly Lys Asn Gly Val Cys 
    50                  55                  60                  


Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr 
65                  70                  75                  80  


Lys Ala Gln Glu Pro Asn Gly Cys Ser Ser Tyr Phe Leu Gly Ile Lys 
                85                  90                  95      


Val Pro Gly Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys 
            100                 105                 110         


Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg 
        115                 120                 125             


Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu 
    130                 135                 140                 


Lys Arg Thr Leu Gly Phe Val Ser Asn Val Glu Ala Ala Cys Asp Ser 
145                 150                 155                 160 


Leu Ala Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro 
                165                 170                 175     


Phe Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys 
            180                 185                 190         


Glu Glu Leu 
        195 


<210>  237
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Phe Pro Arg Glu Lys Thr Trp Asn Ile Ser Phe Ala Gly Cys Gly 
1               5                   10                  15      


Phe Leu Gly Val Tyr Tyr Val Gly Val Ala Ser Cys Leu Arg Glu His 
            20                  25                  30          


Ala Pro Phe Leu Val Ala Asn Ala Thr His Ile Tyr Gly Ala Ser Ala 
        35                  40                  45              


Gly Ala Leu Thr Ala Thr Ala Leu Val Thr Gly Val Cys Leu Gly Glu 
    50                  55                  60                  


Ala Gly Ala Lys Phe Ile Glu Val Ser Lys Glu Ala Arg Lys Arg Phe 
65                  70                  75                  80  


Leu Gly Pro Leu His Pro Ser Phe Asn Leu Val Lys Ile Ile Arg Ser 
                85                  90                  95      


Phe Leu Leu Lys Val Leu Pro Ala Asp Ser His Glu His Ala Ser Gly 
            100                 105                 110         


Arg Leu Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Ile 
        115                 120                 125             


Ile Ser His Phe Asn Ser Lys Asp Glu Leu Ile Gln Ala Asn Val Cys 
    130                 135                 140                 


Ser Gly Phe Ile Pro Val Tyr Cys Gly Leu Ile Pro Pro Ser Leu Gln 
145                 150                 155                 160 


Gly Val Arg Tyr Val Asp Gly Gly Ile Ser Asp Asn Leu Pro Leu Tyr 
                165                 170                 175     


Glu Leu Lys Asn Thr Ile Thr Val Ser Pro Phe Ser Gly Glu Ser Asp 
            180                 185                 190         


Ile Cys Pro Gln Asp Ser Ser Thr Asn Ile His Glu Leu Arg Val Thr 
        195                 200                 205             


Asn Thr Ser Ile Gln Phe Asn Leu Arg Asn Leu Tyr Arg Leu Ser Lys 
    210                 215                 220                 


Ala Leu Phe Pro Pro Glu Pro Leu Val Leu Arg Glu Met Cys Lys Gln 
225                 230                 235                 240 


Gly Tyr Arg Asp Gly Leu Arg Phe Leu Gln Arg Asn Gly Leu Leu Asn 
                245                 250                 255     


Arg Pro Asn Pro Leu Leu Ala Leu Pro Pro Ala Arg Pro His Gly Pro 
            260                 265                 270         


Glu Asp Lys Asp Gln Ala Val Glu Ser Ala Gln Ala Glu Asp Tyr Ser 
        275                 280                 285             


Gln Leu Pro Gly Glu Asp His Ile Leu Glu His Leu Pro Ala Arg Leu 
    290                 295                 300                 


Asn Glu Ala Leu Leu Glu Ala Cys Val Glu Pro Thr Asp Leu Leu Thr 
305                 310                 315                 320 


Thr Leu Ser Asn Met Leu Pro Val Arg Leu Ala Thr Ala Met Met Val 
                325                 330                 335     


Pro Tyr Thr Leu Pro Leu Glu Ser Ala Leu Ser Phe Thr Ile Arg Leu 
            340                 345                 350         


Leu Glu Trp Leu Pro Asp Val Pro Glu Asp Ile Arg Trp Met Lys Glu 
        355                 360                 365             


Gln Thr Gly Ser Ile Cys Gln Tyr Leu Val Met Arg Ala Lys Arg Lys 
    370                 375                 380                 


Leu Gly Arg His Leu Pro Ser Arg Leu Pro Glu Gln Val Glu Leu Arg 
385                 390                 395                 400 


Arg Val Gln Ser Leu Pro Ser Val Pro Leu Ser Cys Ala Ala Tyr Arg 
                405                 410                 415     


Glu Ala Leu Pro Gly Trp Met Arg Asn Asn Leu Ser Leu Gly Asp Ala 
            420                 425                 430         


Leu Ala Lys Trp Glu Glu Cys Gln Arg Gln Leu Leu Leu Gly Leu Phe 
        435                 440                 445             


Cys Thr Asn Val Ala Phe Pro Pro Glu Ala Leu Arg Met Arg Ala Pro 
    450                 455                 460                 


Ala Asp Pro Ala Pro Ala Pro Ala Asp Pro Ala Ser Pro Gln His Gln 
465                 470                 475                 480 


Leu Ala Gly Pro Ala Pro Leu Leu Ser Thr Pro Ala Pro Glu Ala Arg 
                485                 490                 495     


Pro Val Ile Gly Ala Leu Gly Leu 
            500                 


<210>  238
<211>  248
<212>  PRT
<213>  Rattus norvegicus

<400>  238

Met Ser Leu Cys Ser Leu Ala Phe Thr Leu Phe Leu Thr Val Val Ala 
1               5                   10                  15      


Gly Ile Lys Cys Asn Val Thr Asp Val Cys Ala Gly Ser Pro Gly Ile 
            20                  25                  30          


Pro Gly Ala Pro Gly Asn His Gly Leu Pro Gly Arg Asp Gly Arg Asp 
        35                  40                  45              


Gly Val Lys Gly Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
    50                  55                  60                  


Gly Met Pro Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly Gly Pro Gly 
65                  70                  75                  80  


Ala Pro Gly Gly Arg Gly Asp Lys Gly Glu Pro Gly Glu Arg Gly Leu 
                85                  90                  95      


Pro Gly Phe Pro Ala Tyr Leu Asp Glu Glu Leu Gln Thr Glu Leu Tyr 
            100                 105                 110         


Glu Ile Lys His Gln Ile Leu Gln Thr Met Gly Val Leu Ser Leu Gln 
        115                 120                 125             


Gly Ser Met Leu Ser Val Gly Asp Lys Val Phe Ser Thr Asn Gly Gln 
    130                 135                 140                 


Ser Val Asn Phe Asp Thr Ile Lys Glu Met Cys Thr Arg Ala Gly Gly 
145                 150                 155                 160 


Asn Ile Ala Val Pro Arg Thr Pro Glu Glu Asn Glu Ala Ile Ala Ser 
                165                 170                 175     


Ile Ala Lys Lys Tyr Asn Asn Tyr Val Tyr Leu Gly Met Ile Glu Asp 
            180                 185                 190         


Gln Thr Pro Gly Asp Phe His Tyr Leu Asp Gly Ala Ser Val Asn Tyr 
        195                 200                 205             


Thr Asn Trp Tyr Pro Gly Glu Pro Arg Gly Gln Gly Lys Glu Lys Cys 
    210                 215                 220                 


Val Glu Met Tyr Thr Asp Gly Thr Trp Asn Asp Arg Gly Cys Leu Gln 
225                 230                 235                 240 


Tyr Arg Leu Ala Val Cys Glu Phe 
                245             


<210>  239
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Lys His Ile Asn Leu Ser Phe Ala Ala Cys Gly Phe Leu Gly Ile 
1               5                   10                  15      


Tyr His Leu Gly Ala Ala Ser Ala Leu Cys Arg His Gly Lys Lys Leu 
            20                  25                  30          


Val Lys Asp Val Lys Ala Phe Ala Gly Ala Ser Ala Gly Ser Leu Val 
        35                  40                  45              


Ala Ser Val Leu Leu Thr Ala Pro Glu Lys Ile Glu Glu Cys Asn Gln 
    50                  55                  60                  


Phe Thr Tyr Lys Phe Ala Glu Glu Ile Arg Arg Gln Ser Phe Gly Ala 
65                  70                  75                  80  


Val Thr Pro Gly Tyr Asp Phe Met Ala Arg Leu Arg Ser Gly Met Glu 
                85                  90                  95      


Ser Ile Leu Pro Pro Ser Ala His Glu Leu Ala Gln Asn Arg Leu His 
            100                 105                 110         


Val Ser Ile Thr Asn Ala Lys Thr Arg Glu Asn His Leu Val Ser Thr 
        115                 120                 125             


Phe Ser Ser Arg Glu Asp Leu Ile Lys Val Leu Leu Ala Ser Ser Phe 
    130                 135                 140                 


Val Pro Ile Tyr Ala Gly Leu Lys Leu Val Glu Tyr Lys Gly Gln Lys 
145                 150                 155                 160 


Trp Val Asp Gly Gly Leu Thr Asn Ala Leu Pro Ile Leu Pro Val Gly 
                165                 170                 175     


Arg Thr Val Thr Ile Ser Pro Phe Ser Gly Arg Leu Asp Ile Ser Pro 
            180                 185                 190         


Gln Asp Lys Gly Gln Leu Asp Leu Tyr Val Asn Ile Ala Lys Gln Asp 
        195                 200                 205             


Ile Met Leu Ser Leu Ala Asn Leu Val Arg Leu Asn Gln Ala Leu Phe 
    210                 215                 220                 


Pro Pro Ser Lys Arg Lys Met Glu Ser Leu Tyr Gln Cys Gly Phe Asp 
225                 230                 235                 240 


Asp Thr Val Lys Phe Leu Leu Lys Glu Asn Trp Phe Glu 
                245                 250             


<210>  240
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 
1               5                   10                  15      


Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 
            20                  25                  30          


Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu 
        35                  40                  45              


Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val 
    50                  55                  60                  


Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His Ser 
65                  70                  75                  80  


Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr Lys 
                85                  90                  95      


Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala 
            100                 105                 110         


Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 
        115                 120                 125             


Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 
    130                 135                 140                 


Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 
145                 150                 155                 160 


Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 
                165                 170                 175     


Glu Ile 
        


<210>  241
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Pro Gly Gly Leu Leu Leu Gly Asp Val Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Val Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Arg Asn Arg Glu Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Val Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asp Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  242
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  243
<211>  1365
<212>  PRT
<213>  Pongo abelii

<400>  243

Met Leu Leu Ser Pro Ser Leu Leu Leu Pro Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Pro Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu 
            20                  25                  30          


Arg Leu Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu 
        35                  40                  45              


Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu 
    50                  55                  60                  


Asn Cys Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn 
65                  70                  75                  80  


His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe 
                85                  90                  95      


Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu 
            100                 105                 110         


Val Ser Leu Arg Trp Arg Cys Asp Arg Lys Met Ile Thr Gly Pro Leu 
        115                 120                 125             


Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg 
    130                 135                 140                 


Lys Tyr Phe His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile 
145                 150                 155                 160 


Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Ala His 
                165                 170                 175     


Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His 
            180                 185                 190         


Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr 
        195                 200                 205             


Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro 
    210                 215                 220                 


Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn 
225                 230                 235                 240 


Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser 
                245                 250                 255     


Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Ala Leu Leu Ser Ile 
            260                 265                 270         


Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys 
        275                 280                 285             


Thr Val Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly 
    290                 295                 300                 


Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro 
305                 310                 315                 320 


Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser 
                325                 330                 335     


Ser Phe Ile Pro Ser Ala Trp Arg Ser Arg Asp Cys Ala Ser Thr Leu 
            340                 345                 350         


Pro Tyr Val Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val 
        355                 360                 365             


Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp 
    370                 375                 380                 


Asn Pro Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr 
385                 390                 395                 400 


Trp His Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile 
                405                 410                 415     


Asp Ile Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly 
            420                 425                 430         


Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile 
        435                 440                 445             


Pro Val Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn 
    450                 455                 460                 


Trp His Thr Leu Glu Pro Gln Ile Phe Pro Asn Arg Ser Gln Leu Cys 
465                 470                 475                 480 


Val Ser Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu 
                485                 490                 495     


Glu Thr Leu Phe Tyr Val Cys Lys Lys Ala Gly His Val Leu Ser Asp 
            500                 505                 510         


Ala Glu Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys 
        515                 520                 525             


Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly 
    530                 535                 540                 


Tyr Tyr Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln 
545                 550                 555                 560 


Ala Phe Ile Thr Ser Leu Ile Gly Ser Val Val Lys Met Lys Asp Ser 
                565                 570                 575     


Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr 
            580                 585                 590         


Trp Lys Pro Ala Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp 
        595                 600                 605             


Asn Ala His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly 
    610                 615                 620                 


Arg His Pro Pro Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys 
625                 630                 635                 640 


Ala Met Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu 
                645                 650                 655     


Tyr Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser 
            660                 665                 670         


Glu Pro Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val 
        675                 680                 685             


Leu Met Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe 
    690                 695                 700                 


Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val 
705                 710                 715                 720 


Asn Glu Leu Leu Tyr Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe 
                725                 730                 735     


Trp Ile Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu 
            740                 745                 750         


Trp Ser Asp Arg Ile Pro Val Val Ser Ser Phe Leu Asp Asn Asn Tyr 
        755                 760                 765             


Phe Gly Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr 
    770                 775                 780                 


Leu Leu Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile 
785                 790                 795                 800 


Pro Arg Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val 
                805                 810                 815     


Pro Trp Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala 
            820                 825                 830         


Ser Glu Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp 
        835                 840                 845             


Leu Leu Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys 
    850                 855                 860                 


Ile Lys Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln 
865                 870                 875                 880 


Glu Glu Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val 
                885                 890                 895     


Ile Tyr Gln Asn Trp Asp Thr Gly Arg Glu Arg Pro Val Asn Asn Gln 
            900                 905                 910         


Ser Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser 
        915                 920                 925             


Glu Glu Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val 
    930                 935                 940                 


Leu Leu Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys 
945                 950                 955                 960 


Pro Lys Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile 
                965                 970                 975     


Pro Lys Asp Pro Asn Ser Trp Lys Asn Trp Met His Ala Gln His Phe 
            980                 985                 990         


Cys Ala Glu Glu Gly Gly Thr Leu  Val Ala Ile Glu Ser  Glu Val Glu 
        995                 1000                 1005             


Gln Ala  Phe Ile Thr Met Asn  Leu Phe Gly Gln Thr  Thr Asn Val 
    1010                 1015                 1020             


Trp Ile  Gly Leu Gln Asn Asp  Asp Tyr Glu Thr Trp  Leu Asn Gly 
    1025                 1030                 1035             


Lys Pro  Val Val Tyr Ser Asn  Trp Ser Pro Phe Asp  Ile Ile Asn 
    1040                 1045                 1050             


Ile Pro  Ser His Asn Thr Thr  Asp Val Gln Lys His  Ile Pro Leu 
    1055                 1060                 1065             


Cys Ala  Leu Leu Ser Ser Asn  Pro Asn Phe His Phe  Thr Gly Lys 
    1070                 1075                 1080             


Trp Tyr  Phe Glu Asp Cys Gly  Lys Glu Gly Tyr Gly  Phe Val Cys 
    1085                 1090                 1095             


Glu Lys  Met Gln Asp Thr Ser  Gly His Gly Val Asn  Thr Ser Asp 
    1100                 1105                 1110             


Met Tyr  Pro Met Pro Asn Thr  Leu Glu Tyr Gly Asn  Arg Thr Tyr 
    1115                 1120                 1125             


Lys Ile  Ile Asn Ala Asn Met  Thr Trp Tyr Ala Ala  Ile Lys Thr 
    1130                 1135                 1140             


Cys Leu  Met His Gly Thr Gln  Leu Val Ser Ile Thr  Asp Gln Tyr 
    1145                 1150                 1155             


His Gln  Ser Phe Leu Thr Val  Val Leu Asn Arg Leu  Gly Tyr Ala 
    1160                 1165                 1170             


His Trp  Ile Gly Leu Phe Thr  Thr Asp Asn Gly Leu  Asn Phe Asp 
    1175                 1180                 1185             


Trp Ser  Asp Gly Thr Lys Ser  Ser Phe Thr Phe Trp  Lys Asp Glu 
    1190                 1195                 1200             


Glu Ser  Ser Leu Leu Gly Asp  Cys Val Phe Ala Asp  Thr Asn Gly 
    1205                 1210                 1215             


Leu Trp  His Ser Thr Ala Cys  Glu Ser Phe Leu Gln  Gly Ala Ile 
    1220                 1225                 1230             


Cys His  Val Pro Pro Glu Thr  Arg Gln Ser Glu His  Pro Glu Leu 
    1235                 1240                 1245             


Cys Ser  Glu Thr Ser Ile Pro  Trp Ile Lys Phe Lys  Ser Asn Cys 
    1250                 1255                 1260             


Tyr Ser  Phe Ser Thr Val Leu  Asp Arg Met Ser Phe  Glu Ala Ala 
    1265                 1270                 1275             


His Glu  Phe Cys Lys Lys Glu  Gly Ser Asn Leu Leu  Thr Ile Lys 
    1280                 1285                 1290             


Asp Glu  Ala Glu Asn Ala Phe  Leu Leu Glu Glu Leu  Phe Ala Phe 
    1295                 1300                 1305             


Gly Ser  Ser Val Gln Met Val  Trp Leu Asn Ala Gln  Phe Asp Gly 
    1310                 1315                 1320             


Asn Asn  Glu Thr Ile Lys Trp  Phe Asp Gly Thr Pro  Thr Asp Gln 
    1325                 1330                 1335             


Ser Asn  Trp Gly Ile Arg Lys  Pro Asp Thr Asp Tyr  Phe Lys Pro 
    1340                 1345                 1350             


His His  Cys Val Ala Leu Arg  Ile Pro Glu Gly Leu  
    1355                 1360                 1365 


<210>  244
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Tyr Asp Ala Glu Arg Gly Trp Ser Leu Ser Phe Ala Gly Cys Gly 
1               5                   10                  15      


Phe Leu Gly Phe Tyr His Val Gly Ala Thr Arg Cys Leu Ser Glu His 
            20                  25                  30          


Ala Pro His Leu Leu Arg Asp Ala Arg Met Leu Phe Gly Ala Ser Ala 
        35                  40                  45              


Gly Ala Leu His Cys Val Gly Val Leu Ser Gly Ile Pro Leu Glu Gln 
    50                  55                  60                  


Thr Leu Gln Val Leu Ser Asp Leu Val Arg Lys Ala Arg Ser Arg Asn 
65                  70                  75                  80  


Ile Gly Ile Phe His Pro Ser Phe Asn Leu Ser Lys Phe Leu Arg Gln 
                85                  90                  95      


Gly Leu Cys Lys Cys Leu Pro Ala Asn Val His Gln Leu Ile Ser Gly 
            100                 105                 110         


Lys Ile Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Leu 
        115                 120                 125             


Val Ser Asp Phe Arg Ser Lys Asp Glu Val Val Asp Ala Leu Val Cys 
    130                 135                 140                 


Ser Cys Phe Ile Pro Phe Tyr Ser Gly Leu Ile Pro Pro Ser Phe Arg 
145                 150                 155                 160 


Gly Val Arg Tyr Val Asp Gly Gly Val Ser Asp Asn Val Pro Phe Ile 
                165                 170                 175     


Asp Ala Lys Thr Thr Ile Thr Val Ser Pro Phe Tyr Gly Glu Tyr Asp 
            180                 185                 190         


Ile Cys Pro Lys Val Lys Ser Thr Asn Phe Leu His Val Asp Ile Thr 
        195                 200                 205             


Lys Leu Ser Leu Arg Leu Cys Thr Gly Asn Leu Tyr Leu Leu Ser Arg 
    210                 215                 220                 


Ala Phe Val Pro Pro Asp Leu Lys Val Leu Gly Glu Ile Cys Leu Arg 
225                 230                 235                 240 


Gly Tyr Leu Asp Ala Phe Arg Phe Leu Glu Glu Lys Gly Ile Cys Asn 
                245                 250                 255     


Arg Pro Gln Pro Gly Leu Lys Ser Ser Ser Glu Gly Met Asp Pro Glu 
            260                 265                 270         


Val Ala Met Pro Ser Trp Ala Asn Met Ser Leu Asp Ser Ser Pro Glu 
        275                 280                 285             


Ser Ala Ala Leu Ala Val Arg Leu Glu Gly Asp Glu Leu Leu Asp His 
    290                 295                 300                 


Leu Arg Leu Ser Ile Leu Pro Trp Asp Glu Ser Ile Leu Asp Thr Leu 
305                 310                 315                 320 


Ser Pro Arg Leu Ala Thr Ala Leu Ser Glu Glu Met Lys Asp Lys Gly 
                325                 330                 335     


Gly Tyr Met Ser Lys Ile Cys Asn Leu Leu Pro Ile Arg Ile Met Ser 
            340                 345                 350         


Tyr Val Met Leu Pro Cys Thr Leu Pro Val Glu Ser Ala Ile Ala Ile 
        355                 360                 365             


Val Gln Arg Leu Val Thr Trp Leu Pro Asp Met Pro Asp Asp Val Leu 
    370                 375                 380                 


Trp Leu Gln Trp Val Thr Ser Gln Val Phe Thr Arg Val Leu Met Cys 
385                 390                 395                 400 


Leu Leu Pro Ala Ser Arg Ser Gln Met Pro Val Ser Ser Gln Gln Ala 
                405                 410                 415     


Ser Pro Cys Thr Pro Glu Gln Asp Trp Pro Cys Trp Thr Pro Cys Ser 
            420                 425                 430         


Pro Lys Gly Cys Pro Ala Glu Thr Lys Ala Glu Ala Thr Pro Arg Ser 
        435                 440                 445             


Ile Leu Arg Ser Ser Leu Asn Phe Phe Leu Gly Asn Lys Val Pro Ala 
    450                 455                 460                 


Gly Ala Glu Gly Leu Ser Thr Phe Pro Ser Phe Ser Leu Glu Lys Ser 
465                 470                 475                 480 


Leu 
    


<210>  245
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Ser Glu Glu Ser Asp Met Asp Lys Ala Ile Lys Glu Thr Ser Ile 
1               5                   10                  15      


Leu Glu Glu Tyr Ser Ile Asn Trp Thr Gln Lys Leu Gly Ala Gly Ile 
            20                  25                  30          


Ser Gly Pro Val Arg Val Cys Val Lys Lys Ser Thr Gln Glu Arg Phe 
        35                  40                  45              


Ala Leu Lys Ile Leu Leu Asp Arg Pro Lys Ala Arg Asn Glu Val Arg 
    50                  55                  60                  


Leu His Met Met Cys Ala Thr His Pro Asn Ile Val Gln Ile Ile Glu 
65                  70                  75                  80  


Val Phe Ala Asn Ser Val Gln Phe Pro His Glu Ser Ser Pro Arg Ala 
                85                  90                  95      


Arg Leu Leu Ile Val Met Glu Met Met Glu Gly Gly Glu Leu Phe His 
            100                 105                 110         


Arg Ile Ser Gln His Arg His Phe Thr Glu Lys Gln Ala Ser Gln Val 
        115                 120                 125             


Thr Lys Gln Ile Ala Leu Ala Leu Arg His Cys His Leu Leu Asn Ile 
    130                 135                 140                 


Ala His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Lys Asp Asn Ser 
145                 150                 155                 160 


Leu Asp Ala Pro Val Lys Leu Cys Asp Phe Gly Phe Ala Lys Ile Asp 
                165                 170                 175     


Gln Gly Asp Leu Met Thr Pro Gln Phe Thr Pro Tyr Tyr Val Ala Pro 
            180                 185                 190         


Gln Val Leu Glu Ala Gln Arg Arg His Gln Lys Glu Lys Ser Gly Ile 
        195                 200                 205             


Ile Pro Thr Ser Pro Thr Pro Tyr Thr Tyr Asn Lys Ser Cys Asp Leu 
    210                 215                 220                 


Trp Ser Leu Gly Val Ile Ile Tyr Val Met Leu Cys Gly Tyr Pro Pro 
225                 230                 235                 240 


Phe Tyr Ser Lys His His Ser Arg Thr Ile Pro Lys Asp Met Arg Arg 
                245                 250                 255     


Lys Ile Met Thr Gly Ser Phe Glu Phe Pro Glu Glu Glu Trp Ser Gln 
            260                 265                 270         


Ile Ser Glu Met Ala Lys Asp Val Val Arg Lys Leu Leu Lys Val Lys 
        275                 280                 285             


Pro Glu Glu Arg Leu Thr Ile Glu Gly Val Leu Asp His Pro Trp Leu 
    290                 295                 300                 


Asn Ser Thr Glu Ala Leu Asp Asn Val Leu Pro Ser Ala Gln Leu Met 
305                 310                 315                 320 


Met Asp Lys Ala Val Val Ala Gly Ile Gln Gln Ala His Ala Glu Gln 
                325                 330                 335     


Leu Ala Asn Met Arg Ile Gln Asp Leu Lys Val Ser Leu Lys Pro Leu 
            340                 345                 350         


His Ser Val Asn Asn Pro Ile Leu Arg Lys Arg Lys Leu Leu Gly Thr 
        355                 360                 365             


Lys Pro Lys Asp Ser Val Tyr Ile His Asp His Glu Asn Gly Ala Glu 
    370                 375                 380                 


Asp Ser Asn Val Ala Leu Glu Lys Leu Arg Asp Val Ile Ala Gln Cys 
385                 390                 395                 400 


Ile Leu Pro Gln Ala Gly Lys Gly Glu Asn Glu Asp Glu Lys Leu Asn 
                405                 410                 415     


Glu Val Met Gln Glu Ala Trp Lys Tyr Asn Arg Glu Cys Lys Leu Leu 
            420                 425                 430         


Arg Asp Thr Leu Gln Ser Phe Ser Trp Asn Gly Arg Gly Phe Thr Asp 
        435                 440                 445             


Lys Val Asp Arg Leu Lys Leu Ala Glu Ile Val Lys Gln Val Ile Glu 
    450                 455                 460                 


Glu Gln Thr Thr Ser His Glu Ser Gln 
465                 470             


<210>  246
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Ser Glu Glu Ser Asp Met Asp Lys Ala Ile Lys Glu Thr Ser Ile 
1               5                   10                  15      


Leu Glu Glu Tyr Ser Ile Asn Trp Thr Gln Lys Leu Gly Ala Gly Ile 
            20                  25                  30          


Ser Gly Pro Val Arg Val Cys Val Lys Lys Ser Thr Gln Glu Arg Phe 
        35                  40                  45              


Ala Leu Lys Ile Leu Leu Asp Arg Pro Lys Ala Arg Asn Glu Val Arg 
    50                  55                  60                  


Leu His Met Met Cys Ala Thr His Pro Asn Ile Val Gln Ile Ile Glu 
65                  70                  75                  80  


Val Phe Ala Asn Ser Val Gln Phe Pro His Glu Ser Ser Pro Arg Ala 
                85                  90                  95      


Arg Leu Leu Ile Val Met Glu Met Met Glu Gly Gly Glu Leu Phe His 
            100                 105                 110         


Arg Ile Ser Gln His Arg His Phe Thr Glu Lys Gln Ala Ser Gln Val 
        115                 120                 125             


Thr Lys Gln Ile Ala Leu Ala Leu Arg His Cys His Leu Leu Asn Ile 
    130                 135                 140                 


Ala His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Lys Asp Asn Ser 
145                 150                 155                 160 


Leu Asp Ala Pro Val Lys Leu Cys Asp Phe Gly Phe Ala Lys Ile Asp 
                165                 170                 175     


Gln Gly Asp Leu Met Thr Pro Gln Phe Thr Pro Tyr Tyr Val Ala Pro 
            180                 185                 190         


Gln Val Leu Glu Ala Gln Arg Arg His Gln Lys Glu Lys Ser Gly Ile 
        195                 200                 205             


Ile Pro Thr Ser Pro Thr Pro Tyr Thr Tyr Asn Lys Ser Cys Asp Leu 
    210                 215                 220                 


Trp Ser Leu Gly Val Ile Ile Tyr Val Met Leu Cys Gly Tyr Pro Pro 
225                 230                 235                 240 


Phe Tyr Ser Lys His His Ser Arg Thr Ile Pro Lys Asp Met Arg Arg 
                245                 250                 255     


Lys Ile Met Thr Gly Ser Phe Glu Phe Pro Glu Glu Glu Trp Ser Gln 
            260                 265                 270         


Ile Ser Glu Met Ala Lys Asp Val Val Arg Lys Leu Leu Lys Val Lys 
        275                 280                 285             


Pro Glu Glu Arg Leu Thr Ile Glu Gly Val Leu Asp His Pro Trp Leu 
    290                 295                 300                 


Asn Ser Thr Glu Ala Leu Asp Asn Val Leu Pro Ser Ala Gln Leu Met 
305                 310                 315                 320 


Met Asp Lys Ala Val Val Ala Gly Ile Gln Gln Ala His Ala Glu Gln 
                325                 330                 335     


Leu Ala Asn Met Arg Ile Gln Asp Leu Lys Val Ser Leu Lys Pro Leu 
            340                 345                 350         


His Ser Val Asn Asn Pro Ile Leu Arg Lys Arg Lys Leu Leu Gly Thr 
        355                 360                 365             


Lys Pro Lys Asp Ser Val Tyr Ile His Asp His Glu Asn Gly Ala Glu 
    370                 375                 380                 


Asp Ser Asn Val Ala Leu Glu Lys Leu Arg Asp Val Ile Ala Gln Cys 
385                 390                 395                 400 


Ile Leu Pro Gln Ala Gly Glu Asn Glu Asp Glu Lys Leu Asn Glu Val 
                405                 410                 415     


Met Gln Glu Ala Trp Lys Tyr Asn Arg Glu Cys Lys Leu Leu Arg Asp 
            420                 425                 430         


Thr Leu Gln Ser Phe Ser Trp Asn Gly Arg Gly Phe Thr Asp Lys Val 
        435                 440                 445             


Asp Arg Leu Lys Leu Ala Glu Ile Val Lys Gln Val Ile Glu Glu Gln 
    450                 455                 460                 


Thr Thr Ser His Glu Ser Gln 
465                 470     


<210>  247
<211>  230
<212>  PRT
<213>  Rattus norvegicus

<400>  247

Met Cys Gly Asn Asn Met Ser Ala Pro Met Pro Ala Val Val Pro Ala 
1               5                   10                  15      


Ala Arg Lys Ala Thr Ala Ala Val Ile Phe Leu His Gly Leu Gly Asp 
            20                  25                  30          


Thr Gly His Gly Trp Ala Glu Ala Phe Ala Gly Ile Lys Ser Ser His 
        35                  40                  45              


Ile Lys Tyr Ile Cys Pro His Ala Pro Val Met Pro Val Thr Leu Asn 
    50                  55                  60                  


Met Ser Met Met Met Pro Ser Trp Phe Asp Ile Ile Gly Leu Ser Pro 
65                  70                  75                  80  


Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Thr Val 
                85                  90                  95      


Lys Ala Leu Ile Asp Gln Glu Val Lys Asn Gly Ile Pro Ser Asn Arg 
            100                 105                 110         


Ile Ile Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr 
        115                 120                 125             


Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys 
    130                 135                 140                 


Trp Leu Pro Leu Arg Ala Ser Phe Ser Gln Gly Pro Ile Asn Ser Ala 
145                 150                 155                 160 


Asn Arg Asp Ile Ser Val Leu Gln Cys His Gly Asp Cys Asp Pro Leu 
                165                 170                 175     


Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Arg Leu Lys Gly Leu 
            180                 185                 190         


Val Asn Pro Ala Asn Val Thr Phe Lys Val Tyr Glu Gly Met Met His 
        195                 200                 205             


Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys Tyr Phe Ile Asp Lys 
    210                 215                 220                 


Leu Leu Pro Pro Ile Asp 
225                 230 


<210>  248
<211>  670
<212>  PRT
<213>  Rattus norvegicus

<400>  248

Met Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser Gln Trp Phe Ala 
1               5                   10                  15      


Gly Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Ile Gly Ser Ala Gly Cys 
            20                  25                  30          


Ser Glu Lys His Leu Leu Asp Lys Ala Phe Tyr Asn Asp Phe Glu Arg 
        35                  40                  45              


Gly Gly Arg Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly Glu 
    50                  55                  60                  


Ile Tyr Leu Val Lys Ile Glu Lys Arg Lys Tyr Arg Leu His Asp Asp 
65                  70                  75                  80  


Trp Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Asp Tyr Ile Glu 
                85                  90                  95      


Phe Pro Cys Tyr Arg Trp Ile Thr Gly Glu Gly Glu Ile Val Leu Arg 
            100                 105                 110         


Asp Gly Cys Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile Leu Lys 
        115                 120                 125             


Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr Arg Trp 
    130                 135                 140                 


Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys Cys His 
145                 150                 155                 160 


Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly Val Asp 
                165                 170                 175     


Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile Asn Arg 
            180                 185                 190         


Phe Met His Met Phe Gln Ser Ser Trp His Asp Phe Ala Asp Phe Glu 
        195                 200                 205             


Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val Lys Asn 
    210                 215                 220                 


His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn Gly Cys 
225                 230                 235                 240 


Asn Pro Val Leu Ile Lys Arg Cys Thr Glu Leu Pro Lys Lys Leu Pro 
                245                 250                 255     


Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu Ser Leu 
            260                 265                 270         


Glu Gln Glu Val Gln Glu Gly Asn Ile Phe Ile Val Asp Tyr Glu Leu 
        275                 280                 285             


Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr His Gln Phe 
    290                 295                 300                 


Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn Lys Ile 
305                 310                 315                 320 


Val Pro Ile Ala Ile Gln Leu Asn Gln Thr Pro Gly Glu Lys Asn Pro 
                325                 330                 335     


Ile Phe Leu Pro Thr Asp Ser Lys Tyr Asp Trp Leu Leu Ala Lys Ile 
            340                 345                 350         


Trp Val Arg Ser Ser Asp Phe His Ile His Gln Thr Ile Thr His Leu 
        355                 360                 365             


Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met Tyr Arg 
    370                 375                 380                 


Gln Leu Pro Ala Val His Pro Leu Phe Lys Leu Leu Val Ala His Val 
385                 390                 395                 400 


Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu Asn Cys 
                405                 410                 415     


Glu Tyr Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly Gly His 
            420                 425                 430         


Val Gln Met Val Gln Arg Ala Val Gln Asp Leu Thr Tyr Ser Ser Leu 
        435                 440                 445             


Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Asp Asn Thr Glu Asp 
    450                 455                 460                 


Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp Glu Ala 
465                 470                 475                 480 


Ile Gln Ser Phe Thr Thr Glu Val Val Ser Ile Tyr Tyr Glu Asp Asp 
                485                 490                 495     


Gln Val Val Glu Glu Asp Gln Glu Leu Gln Asp Phe Val Lys Asp Val 
            500                 505                 510         


Tyr Val Tyr Gly Met Arg Gly Arg Lys Ala Ser Gly Phe Pro Lys Ser 
        515                 520                 525             


Ile Lys Ser Arg Glu Lys Leu Ser Glu Tyr Leu Thr Val Val Ile Phe 
    530                 535                 540                 


Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr Asp Trp 
545                 550                 555                 560 


Cys Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro Pro Pro 
                565                 570                 575     


Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr Leu Pro 
            580                 585                 590         


Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala Leu Ser 
        595                 600                 605             


Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu Glu His 
    610                 615                 620                 


Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ile Arg Phe Arg Lys Asn 
625                 630                 635                 640 


Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Lys Asn Lys Lys 
                645                 650                 655     


Leu Pro Tyr Tyr Tyr Leu Ser Pro Asp Arg Phe Gln Thr Val 
            660                 665                 670 


<210>  249
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Tyr Asp Ala Glu Arg Gly Trp Ser Leu Ser Phe Ala Gly Cys Gly 
1               5                   10                  15      


Phe Leu Gly Phe Tyr His Val Gly Ala Thr Arg Cys Leu Ser Glu His 
            20                  25                  30          


Ala Pro His Leu Leu Arg Asp Ala Arg Met Leu Phe Gly Ala Ser Ala 
        35                  40                  45              


Gly Ala Leu His Cys Val Gly Val Leu Ser Gly Ile Pro Leu Glu Gln 
    50                  55                  60                  


Thr Leu Gln Val Leu Ser Asp Leu Val Arg Lys Ala Arg Ser Arg Asn 
65                  70                  75                  80  


Ile Gly Ile Phe His Pro Ser Phe Asn Leu Ser Lys Phe Leu Arg Gln 
                85                  90                  95      


Gly Leu Cys Lys Cys Leu Pro Ala Asn Val His Gln Leu Ile Ser Gly 
            100                 105                 110         


Lys Ile Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Leu 
        115                 120                 125             


Val Ser Asp Phe Arg Ser Lys Asp Glu Val Val Asp Ala Leu Val Cys 
    130                 135                 140                 


Ser Cys Phe Ile Pro Phe Tyr Ser Gly Leu Ile Pro Pro Ser Phe Arg 
145                 150                 155                 160 


Gly Val Arg Tyr Val Asp Gly Gly Val Ser Asp Asn Val Pro Phe Ile 
                165                 170                 175     


Asp Ala Lys Thr Thr Ile Thr Val Ser Pro Phe Tyr Gly Glu Tyr Asp 
            180                 185                 190         


Ile Cys Pro Lys Val Lys Ser Thr Asn Phe Leu His Val Asp Ile Thr 
        195                 200                 205             


Lys Leu Ser Leu Arg Leu Cys Thr Gly Asn Leu Tyr Leu Leu Ser Arg 
    210                 215                 220                 


Ala Phe Val Pro Pro Asp Leu Lys Val Leu Gly Glu Ile Cys Leu Arg 
225                 230                 235                 240 


Gly Tyr Leu Asp Ala Phe Arg Phe Leu Glu Glu Lys Gly Ile Cys Asn 
                245                 250                 255     


Arg Pro Gln Pro Gly Leu Lys Ser Ser Ser Glu Gly Met Asp Pro Glu 
            260                 265                 270         


Val Ala Met Pro Ser Trp Ala Asn Met Ser Leu Asp Ser Ser Pro Glu 
        275                 280                 285             


Ser Ala Ala Leu Ala Val Arg Leu Glu Gly Asp Glu Leu Leu Asp His 
    290                 295                 300                 


Leu Arg Leu Ser Ile Leu Pro Trp Asp Glu Ser Ile Leu Asp Thr Leu 
305                 310                 315                 320 


Ser Pro Arg Leu Ala Thr Ala Leu Ser Glu Glu Met Lys Asp Lys Gly 
                325                 330                 335     


Gly Tyr Met Ser Lys Ile Cys Asn Leu Leu Pro Ile Arg Ile Met Ser 
            340                 345                 350         


Tyr Val Met Leu Pro Cys Thr Leu Pro Val Glu Ser Ala Ile Ala Ile 
        355                 360                 365             


Val Gln Arg Leu Val Thr Trp Leu Pro Asp Met Pro Asp Asp Val Leu 
    370                 375                 380                 


Trp Leu Gln Trp Val Thr Ser Gln Val Phe Thr Arg Val Leu Met Cys 
385                 390                 395                 400 


Leu Leu Pro Ala Ser Arg Ser Gln Met Pro Val Ser Ser Gln Gln Ala 
                405                 410                 415     


Ser Pro Cys Thr Pro Glu Gln Asp Trp Pro Cys Trp Thr Pro Cys Ser 
            420                 425                 430         


Pro Lys Gly Cys Pro Ala Glu Thr Lys Ala Glu Ala Thr Pro Arg Ser 
        435                 440                 445             


Ile Leu Arg Ser Ser Leu Asn Phe Phe Leu Gly Asn Lys Val Pro Ala 
    450                 455                 460                 


Gly Ala Glu Gly Leu Ser Thr Phe Pro Ser Phe Ser Leu Glu Lys Ser 
465                 470                 475                 480 


Leu 
    


<210>  250
<211>  230
<212>  PRT
<213>  Rattus norvegicus

<400>  250

Met Cys Gly Asn Asn Met Ser Ala Pro Met Pro Ala Val Val Pro Ala 
1               5                   10                  15      


Ala Arg Lys Ala Thr Ala Ala Val Ile Phe Leu His Gly Leu Gly Asp 
            20                  25                  30          


Thr Gly His Gly Trp Ala Glu Ala Phe Ala Gly Ile Lys Ser Ser His 
        35                  40                  45              


Ile Lys Tyr Ile Cys Pro His Ala Pro Val Met Pro Val Thr Leu Asn 
    50                  55                  60                  


Met Ser Met Met Met Pro Ser Trp Phe Asp Ile Ile Gly Leu Ser Pro 
65                  70                  75                  80  


Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Thr Val 
                85                  90                  95      


Lys Ala Leu Ile Asp Gln Glu Val Lys Asn Gly Ile Pro Ser Asn Arg 
            100                 105                 110         


Ile Ile Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr 
        115                 120                 125             


Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys 
    130                 135                 140                 


Trp Leu Pro Leu Arg Ala Ser Phe Ser Gln Gly Pro Ile Asn Ser Ala 
145                 150                 155                 160 


Asn Arg Asp Ile Ser Val Leu Gln Cys His Gly Asp Cys Asp Pro Leu 
                165                 170                 175     


Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Arg Leu Lys Gly Leu 
            180                 185                 190         


Val Asn Pro Ala Asn Val Thr Phe Lys Val Tyr Glu Gly Met Met His 
        195                 200                 205             


Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys Tyr Phe Ile Asp Lys 
    210                 215                 220                 


Leu Leu Pro Pro Ile Asp 
225                 230 


<210>  251
<211>  266
<212>  PRT
<213>  Macaca fascicularis

<400>  251

Met Ser Trp Ser His Ala Phe Tyr Asp Ser Gln Ala Trp Glu Asn Ile 
1               5                   10                  15      


Leu Arg Asp Arg Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn 
            20                  25                  30          


Pro Thr Cys Pro Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly 
        35                  40                  45              


Ile Thr Pro Lys Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly 
    50                  55                  60                  


Asn Asn Ser His Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala 
65                  70                  75                  80  


Ile Arg Ala Ser Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu 
                85                  90                  95      


Gly Asn Asp Leu His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser 
            100                 105                 110         


Ala Leu Ala Met His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu 
        115                 120                 125             


Glu Cys Ile Val Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg 
    130                 135                 140                 


Asn Thr Val Thr His Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile 
145                 150                 155                 160 


Asn Ser Ala Thr Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu 
                165                 170                 175     


Leu Pro Pro Asp Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn 
            180                 185                 190         


Ile Pro Leu Asp Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu 
        195                 200                 205             


Glu Gly Leu Lys Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val 
    210                 215                 220                 


Ala Lys Ile Leu Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp 
225                 230                 235                 240 


Trp Ile Lys Leu Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser 
                245                 250                 255     


Asn Cys Asp Glu Tyr Met His Met Ala Ser 
            260                 265     


<210>  252
<211>  803
<212>  PRT
<213>  Mus musculus

<400>  252

Met Ser Ile Asn Leu Thr Leu Asp Ile Tyr Ile Tyr Phe Leu Asn Asn 
1               5                   10                  15      


Ala Arg Ser Leu Cys Gly Lys Gln Arg Ser Lys Gln Leu His Phe Val 
            20                  25                  30          


Cys Ser Lys Gln Tyr Trp Arg Met Asn His Val Asn Val His Arg Glu 
        35                  40                  45              


Phe His Thr Ser Lys Lys Ser Cys Lys Trp Asn Arg Ser Glu Ala His 
    50                  55                  60                  


Cys Ser Lys His Trp His Ser Pro Ser Asn His Gly Leu His Phe Gly 
65                  70                  75                  80  


Ile Val Arg Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys Val Ser 
                85                  90                  95      


Ile His Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser Lys Ala 
            100                 105                 110         


Ile Phe Gly Ser Gln Asn Glu Met Val Thr Arg Leu Ala Gln Phe Lys 
        115                 120                 125             


Pro Ser Ser Arg Ile Leu Arg Lys Val Ser Asp Lys Gly Trp Leu Lys 
    130                 135                 140                 


Gln Lys Asn Val Lys Gln Ala Val Glu Ser Leu Lys Asn Tyr Ser Asp 
145                 150                 155                 160 


Lys Ser Ala Gly Lys Asn Ser Leu Ala Glu Gln Lys Ser Tyr Phe Ala 
                165                 170                 175     


Asp Lys Glu Glu Asp Ser Gly Lys His Ser Leu Phe His Tyr Thr Tyr 
            180                 185                 190         


Gly Ile Thr Thr Arg Phe Gly Glu Ser Phe Ser Val Leu Ala Asn His 
        195                 200                 205             


Ile Asn Ser Tyr Phe Lys Ser Lys Gly Lys Met Ser Gln Thr Lys Glu 
    210                 215                 220                 


Asp Lys Gln Leu Gln Asp Lys Pro Asp Leu Glu Glu Arg Lys Ser Ser 
225                 230                 235                 240 


Ser Pro Gly Pro Asp Thr Val Ala Asp Arg Pro Asp Ser Glu Ser Pro 
                245                 250                 255     


Leu Glu Val Lys Asp Lys Leu Ser Ser Pro Thr Gln Met Pro Glu Ala 
            260                 265                 270         


His Pro Val Ser Ala Lys Gln Ser Ile Ala Asn Phe Leu Ser Arg Pro 
        275                 280                 285             


Thr Glu Gly Val Gln Ala Leu Val Gly Gly Tyr Ile Gly Gly Leu Val 
    290                 295                 300                 


Pro Lys Leu Lys Ser Asp Pro Lys Ser Pro Pro Glu Glu Gln Glu Val 
305                 310                 315                 320 


Ser Ala Lys Thr Glu Gln Ala Val Asn Lys Asp Lys Lys Ala Glu Glu 
                325                 330                 335     


Lys Lys Arg Val Leu Leu Gln Gln Glu Lys Ile Ile Ala Arg Val Ser 
            340                 345                 350         


Ile Asp Asn Arg Thr Arg Ala Leu Val Gln Ala Leu Arg Arg Thr Ala 
        355                 360                 365             


Asp Pro Lys Leu Cys Ile Thr Arg Val Glu Glu Leu Thr Phe His Leu 
    370                 375                 380                 


Leu Glu Phe Pro Glu Gly Lys Gly Val Ala Ile Lys Glu Lys Ile Ile 
385                 390                 395                 400 


Pro Tyr Leu Leu Arg Leu Arg Gln Val Lys Asp Glu Thr Leu Gln Ala 
                405                 410                 415     


Ala Val Arg Glu Ile Leu Ala Leu Ile Gly Tyr Val Asp Pro Val Lys 
            420                 425                 430         


Gly Arg Gly Ile Arg Ile Leu Thr Ile Asp Gly Gly Gly Thr Arg Gly 
        435                 440                 445             


Val Val Ala Leu Gln Thr Leu Arg Lys Leu Val Glu Leu Thr Gln Lys 
    450                 455                 460                 


Pro Ile His Gln Leu Phe Asp Tyr Ile Cys Gly Val Ser Thr Gly Ala 
465                 470                 475                 480 


Ile Leu Ala Phe Met Leu Gly Leu Phe His Met Pro Leu Asp Glu Cys 
                485                 490                 495     


Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp Val Phe Thr Gln Asn Val 
            500                 505                 510         


Ile Val Gly Thr Val Lys Met Ser Trp Ser His Ala Phe Tyr Asp Ser 
        515                 520                 525             


Asn Thr Trp Glu Lys Ile Leu Lys Asp Arg Ile Gly Ser Ala Leu Met 
    530                 535                 540                 


Ile Glu Thr Ala Arg Asn Pro Ala Cys Pro Lys Val Ala Ala Ile Ser 
545                 550                 555                 560 


Thr Ile Val Asn Arg Gly Gln Thr Pro Lys Ala Phe Val Phe Arg Asn 
                565                 570                 575     


Tyr Gly His Phe Pro Gly Thr Asn Ser His Tyr Leu Gly Gly Cys Gln 
            580                 585                 590         


Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro Gly Tyr 
        595                 600                 605             


Phe Ala Glu Tyr Ala Leu Gly Ser Asp Leu His Gln Asp Gly Gly Leu 
    610                 615                 620                 


Leu Leu Asn Asn Pro Ser Ala Leu Ala Leu His Glu Cys Lys Cys Ile 
625                 630                 635                 640 


Trp Pro Asp Thr Pro Leu Glu Cys Ile Val Ser Leu Gly Thr Gly Arg 
                645                 650                 655     


Tyr Glu Ser Asp Val Arg Asn Thr Ser Thr Tyr Thr Ser Leu Lys Thr 
            660                 665                 670         


Lys Leu Ser Asn Val Ile Ser Ser Ala Thr Asp Thr Glu Glu Val His 
        675                 680                 685             


Ile Met Leu Asp Gly Leu Leu Pro Ser Asp Thr Tyr Phe Arg Phe Asn 
    690                 695                 700                 


Pro Val Ile Cys Glu Asn Ile Pro Leu Asp Glu Ser Arg Asp Glu Lys 
705                 710                 715                 720 


Leu Asp Gln Leu Gln Leu Glu Gly Met Lys Tyr Ile Glu Arg Asn Asp 
                725                 730                 735     


Gln Lys Met Lys Lys Val Ala Lys Ile Leu Ser Gln Glu Lys Thr Thr 
            740                 745                 750         


Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu Lys Ser Asp Met Tyr Glu 
        755                 760                 765             


Gly Leu Pro Phe Phe Ser Lys Leu Trp Val Gly Tyr Thr Cys Val Leu 
    770                 775                 780                 


Ile Asn Glu Gly His Gln Lys Ile His Gln Phe Arg Glu Glu Arg Cys 
785                 790                 795                 800 


Asp Ser Thr 
            


<210>  253
<211>  91
<212>  PRT
<213>  Equus caballus

<400>  253

Met Lys Leu Ala Ile Thr Ile Thr Leu Ala Ile Leu Ala Leu Cys Cys 
1               5                   10                  15      


Ser Pro Ala Ser Ala Glu Ile Cys Gln Ser Phe Ala Asp Ile Ile Gln 
            20                  25                  30          


Gly Leu Phe Leu Gly Thr Pro Ala Ser Phe Glu Ala Ala Val Glu Pro 
        35                  40                  45              


Phe Lys Pro Asp Ala Asp Met Lys Ala Ala Thr Thr Gln Leu Lys Thr 
    50                  55                  60                  


Leu Val Asp Phe Leu Pro Lys Asn Thr Lys Asp Ser Ile Leu Lys Leu 
65                  70                  75                  80  


Met Asp Lys Ile Ala Lys Ser Pro Leu Cys Ala 
                85                  90      


<210>  254
<211>  73
<212>  PRT
<213>  Equus caballus

<400>  254

Ala Leu Cys Cys Ser Pro Ala Ser Ala Gly Ile Cys Gln Arg Phe Val 
1               5                   10                  15      


Gly Ile Val Gln Ala Leu Tyr Leu Gly Thr Pro Ala Ser Phe Glu Ala 
            20                  25                  30          


Ala Val Glu Pro Phe Lys Pro Asp Ala Asp Met Lys Ala Ala Ala Thr 
        35                  40                  45              


Gln Leu Lys Thr Leu Val Asp Phe Leu Pro Lys Asn Ala Lys Asp Ser 
    50                  55                  60                  


Ile Leu Lys Leu Met Asp Lys Ile Val 
65                  70              


<210>  255
<211>  73
<212>  PRT
<213>  Equus caballus

<400>  255

Ala Leu Cys Cys Ser Pro Ala Ser Ala Gly Ile Cys Gln Arg Phe Val 
1               5                   10                  15      


Gly Ile Val Gln Ala Leu Tyr Leu Gly Thr Pro Ala Ser Phe Glu Ala 
            20                  25                  30          


Ala Val Glu Pro Phe Lys Pro Asp Ala Asp Met Lys Ala Ala Ala Thr 
        35                  40                  45              


Gln Leu Lys Thr Leu Val Asp Phe Leu Pro Lys Asn Ala Lys Asp Ser 
    50                  55                  60                  


Ile Leu Lys Leu Met Asp Lys Ile Val 
65                  70              


<210>  256
<211>  73
<212>  PRT
<213>  Equus caballus

<400>  256

Ala Leu Cys Cys Ser Pro Ala Ser Ala Gly Ile Cys Gln Arg Phe Val 
1               5                   10                  15      


Gly Ile Val Gln Ala Leu Tyr Leu Gly Thr Pro Ala Ser Phe Glu Ala 
            20                  25                  30          


Ala Val Glu Pro Phe Lys Pro Asp Ala Asp Met Lys Ala Ala Ala Thr 
        35                  40                  45              


Gln Leu Lys Thr Leu Val Asp Phe Leu Pro Lys Asn Ala Lys Asp Ser 
    50                  55                  60                  


Ile Leu Lys Leu Met Asp Lys Ile Val 
65                  70              


<210>  257
<211>  73
<212>  PRT
<213>  Equus caballus

<400>  257

Ala Leu Cys Cys Ser Pro Ala Ser Ala Gly Ile Cys Gln Arg Phe Val 
1               5                   10                  15      


Gly Ile Val Gln Ala Leu Tyr Leu Gly Thr Pro Ala Ser Phe Glu Ala 
            20                  25                  30          


Ala Val Glu Pro Phe Lys Pro Asp Ala Asp Met Lys Ala Ala Ala Thr 
        35                  40                  45              


Gln Leu Lys Thr Leu Val Asp Phe Leu Pro Lys Asn Ala Lys Asp Ser 
    50                  55                  60                  


Ile Leu Lys Leu Met Asp Lys Ile Val 
65                  70              


<210>  258
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  258

Met Lys Leu Leu Cys Gly Phe Phe Leu Leu Trp Leu Gly Leu Val Gly 
1               5                   10                  15      


Asn Leu Ala Gln Ser Asp Pro Ser Pro Lys Glu Glu Glu Ser Tyr Ser 
            20                  25                  30          


Asp Trp Gly Leu Arg Gln Leu Arg Gly Ser Phe Glu Ser Val Asn Ser 
        35                  40                  45              


Tyr Val Asp Ser Phe Met Glu Leu Leu Gly Gly Lys Asn Gly Val Cys 
    50                  55                  60                  


Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr 
65                  70                  75                  80  


Lys Ala Gln Glu Pro Asn Gly Cys Ser Ser Tyr Phe Leu Gly Ile Lys 
                85                  90                  95      


Val Pro Gly Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys 
            100                 105                 110         


Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg 
        115                 120                 125             


Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu 
    130                 135                 140                 


Lys Arg Ser Leu Gly Phe Val Ser Asn Val Glu Ala Ala Cys Asp Ser 
145                 150                 155                 160 


Leu Ala Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro 
                165                 170                 175     


Phe Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys 
            180                 185                 190         


Glu Glu Leu 
        195 


<210>  259
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Lys Leu Ala Ser Gly Phe Leu Val Leu Trp Leu Ser Leu Gly Gly 
1               5                   10                  15      


Gly Leu Ala Gln Ser Asp Thr Ser Pro Asp Thr Glu Glu Ser Tyr Ser 
            20                  25                  30          


Asp Trp Gly Leu Arg His Leu Arg Gly Ser Phe Glu Ser Val Asn Ser 
        35                  40                  45              


Tyr Phe Asp Ser Phe Leu Glu Leu Leu Gly Gly Lys Asn Gly Val Cys 
    50                  55                  60                  


Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr 
65                  70                  75                  80  


Lys Pro Gln Glu Pro Asn Gly Cys Gly Ser Tyr Phe Leu Gly Leu Lys 
                85                  90                  95      


Val Pro Glu Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys 
            100                 105                 110         


Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg 
        115                 120                 125             


Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu 
    130                 135                 140                 


Lys Arg Ser Leu Gly Phe Val Ser Lys Val Glu Ala Ala Cys Asp Ser 
145                 150                 155                 160 


Leu Val Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro 
                165                 170                 175     


Phe Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys 
            180                 185                 190         


Glu Glu Leu 
        195 


<210>  260
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys 
    130                 135                 140                 


Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val 
145                 150                 155                 160 


Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn 
                165                 170                 175     


Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro 
            180                 185                 190         


Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys 
        195                 200                 205             


Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu 
    210                 215                 220                 


Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly 
225                 230                 235                 240 


Ala Glu Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser 
                245                 250                 255     


Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val 
            260                 265                 270         


Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu 
        275                 280                 285             


Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro 
    290                 295                 300                 


Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe 
305                 310                 315                 320 


Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro 
                325                 330                 335     


Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly 
            340                 345                 350         


Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365         


<210>  261
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Gly Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro 
                325         


<210>  262
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Ser Gln Gly Asp Ser Asn Pro Ala Ala Ile Pro His Ala Ala Glu 
1               5                   10                  15      


Asp Ile Gln Gly Asp Asp Arg Trp Met Ser Gln His Asn Arg Phe Val 
            20                  25                  30          


Leu Asp Cys Lys Asp Lys Glu Pro Asp Val Leu Phe Val Gly Asp Ser 
        35                  40                  45              


Met Val Gln Leu Met Gln Gln Tyr Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Thr Thr Arg His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Lys Asn Gly Glu Leu Glu Asn Ile Lys Pro Lys 
                85                  90                  95      


Val Ile Val Val Trp Val Gly Thr Asn Asn His Glu Asn Thr Ala Glu 
            100                 105                 110         


Glu Val Ala Gly Gly Ile Glu Ala Ile Val Gln Leu Ile Asn Thr Arg 
        115                 120                 125             


Gln Pro Gln Ala Lys Ile Ile Val Leu Gly Leu Leu Pro Arg Gly Glu 
    130                 135                 140                 


Lys Pro Asn Pro Leu Arg Gln Lys Asn Ala Lys Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Val Ser Leu Pro Lys Leu Ala Asn Val Gln Leu Leu Asp Thr Asp 
                165                 170                 175     


Gly Gly Phe Val His Ser Asp Gly Ala Ile Ser Cys His Asp Met Phe 
            180                 185                 190         


Asp Phe Leu His Leu Thr Gly Gly Gly Tyr Ala Lys Ile Cys Lys Pro 
        195                 200                 205             


Leu His Glu Leu Ile Met Gln Leu Leu Glu Glu Thr Pro Glu Glu Lys 
    210                 215                 220                 


Gln Thr Thr Ile Ala 
225                 


<210>  263
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            


<210>  264
<211>  51
<212>  PRT
<213>  Cavia porcellus

<400>  264

His Ala Leu Asp Thr Pro His Phe Pro Gln Glu Leu Thr Ser Ala Leu 
1               5                   10                  15      


Ser Lys Asn Ile Cys Ile Thr Phe Phe Ser Gly Met Phe Lys Asn Val 
            20                  25                  30          


Glu Ser Val Ala Glu Ile Phe Asp Ser Leu Gly Pro Ser Phe Lys Gln 
        35                  40                  45              


Asp Gln Ala 
    50      


<210>  265
<211>  467
<212>  PRT
<213>  Canis familiaris

<400>  265

Met Val Ser Ile Trp Thr Ile Ala Leu Phe Leu Leu Gly Ala Ala Lys 
1               5                   10                  15      


Ala Lys Glu Val Cys Tyr Glu Gln Ile Gly Cys Phe Ser Asp Ala Glu 
            20                  25                  30          


Pro Trp Ala Gly Thr Ala Ile Arg Pro Leu Lys Val Leu Pro Trp Ser 
        35                  40                  45              


Pro Glu Arg Ile Gly Thr Arg Phe Leu Leu Tyr Thr Asn Lys Asn Pro 
    50                  55                  60                  


Asn Asn Phe Gln Thr Leu Leu Pro Ser Asp Pro Ser Thr Ile Glu Ala 
65                  70                  75                  80  


Ser Asn Phe Gln Thr Asp Lys Lys Thr Arg Phe Ile Ile His Gly Phe 
                85                  90                  95      


Ile Asp Lys Gly Glu Glu Asn Trp Leu Leu Asp Met Cys Lys Asn Met 
            100                 105                 110         


Phe Lys Val Glu Glu Val Asn Cys Ile Cys Val Asp Trp Lys Lys Gly 
        115                 120                 125             


Ser Gln Thr Ser Tyr Thr Gln Ala Ala Asn Asn Val Arg Val Val Gly 
    130                 135                 140                 


Ala Gln Val Ala Gln Met Leu Ser Met Leu Ser Ala Asn Tyr Ser Tyr 
145                 150                 155                 160 


Ser Pro Ser Gln Val Gln Leu Ile Gly His Ser Leu Gly Ala His Val 
                165                 170                 175     


Ala Gly Glu Ala Gly Ser Arg Thr Pro Gly Leu Gly Arg Ile Thr Gly 
            180                 185                 190         


Leu Asp Pro Val Glu Ala Ser Phe Gln Gly Thr Pro Glu Glu Val Arg 
        195                 200                 205             


Leu Asp Pro Thr Asp Ala Asp Phe Val Asp Val Ile His Thr Asp Ala 
    210                 215                 220                 


Ala Pro Leu Ile Pro Phe Leu Gly Phe Gly Thr Ser Gln Gln Met Gly 
225                 230                 235                 240 


His Leu Asp Phe Phe Pro Asn Gly Gly Glu Glu Met Pro Gly Cys Lys 
                245                 250                 255     


Lys Asn Ala Leu Ser Gln Ile Val Asp Leu Asp Gly Ile Trp Glu Gly 
            260                 265                 270         


Thr Arg Asp Phe Val Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr 
        275                 280                 285             


Ser Glu Ser Ile Leu Asn Pro Asp Gly Phe Ala Ser Tyr Pro Cys Ala 
    290                 295                 300                 


Ser Tyr Arg Ala Phe Glu Ser Asn Lys Cys Phe Pro Cys Pro Asp Gln 
305                 310                 315                 320 


Gly Cys Pro Gln Met Gly His Tyr Ala Asp Lys Phe Ala Val Lys Thr 
                325                 330                 335     


Ser Asp Glu Thr Gln Lys Tyr Phe Leu Asn Thr Gly Asp Ser Ser Asn 
            340                 345                 350         


Phe Ala Arg Trp Arg Tyr Gly Val Ser Ile Thr Leu Ser Gly Lys Arg 
        355                 360                 365             


Ala Thr Gly Gln Ala Lys Val Ala Leu Phe Gly Ser Lys Gly Asn Thr 
    370                 375                 380                 


His Gln Phe Asn Ile Phe Lys Gly Ile Leu Lys Pro Gly Ser Thr His 
385                 390                 395                 400 


Ser Asn Glu Phe Asp Ala Lys Leu Asp Val Gly Thr Ile Glu Lys Val 
                405                 410                 415     


Lys Phe Leu Trp Asn Asn Asn Val Val Asn Pro Thr Phe Pro Lys Val 
            420                 425                 430         


Gly Ala Ala Lys Ile Thr Val Gln Lys Gly Glu Glu Lys Thr Val His 
        435                 440                 445             


Ser Phe Cys Ser Glu Ser Thr Val Arg Glu Asp Val Leu Leu Thr Leu 
    450                 455                 460                 


Thr Pro Cys 
465         


<210>  266
<211>  229
<212>  PRT
<213>  Mus musculus

<400>  266

Met Ser Gln Gly Asp Ser Asn Pro Ala Ala Ile Pro His Ala Ala Glu 
1               5                   10                  15      


Asp Ile Gln Gly Asp Asp Arg Trp Met Ser Gln His Asn Arg Phe Val 
            20                  25                  30          


Leu Asp Cys Lys Asp Lys Glu Pro Asp Val Leu Phe Val Gly Asp Ser 
        35                  40                  45              


Met Val Gln Leu Met Gln Gln Tyr Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Thr Thr Arg His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Lys Asn Gly Glu Leu Glu Asn Ile Lys Pro Lys 
                85                  90                  95      


Val Ile Val Val Trp Val Gly Thr Asn Asn His Glu Asn Thr Ala Glu 
            100                 105                 110         


Glu Val Ala Gly Gly Ile Glu Ala Ile Val Gln Leu Ile Asn Thr Arg 
        115                 120                 125             


Gln Pro Gln Ala Lys Ile Ile Val Leu Gly Leu Leu Pro Arg Gly Glu 
    130                 135                 140                 


Lys Pro Asn Pro Leu Arg Gln Lys Asn Ala Lys Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Val Ser Leu Pro Lys Leu Ala Asn Val Gln Leu Leu Asp Ile Asp 
                165                 170                 175     


Gly Gly Phe Val His Ser Asp Gly Ala Ile Ser Cys His Asp Met Phe 
            180                 185                 190         


Asp Phe Leu His Leu Thr Gly Gly Gly Tyr Ala Lys Ile Cys Lys Pro 
        195                 200                 205             


Leu His Glu Leu Ile Met Gln Leu Leu Glu Glu Thr Pro Glu Glu Lys 
    210                 215                 220                 


Gln Thr Thr Ile Ala 
225                 


<210>  267
<211>  232
<212>  PRT
<213>  Mus musculus

<400>  267

Met Ser Gly Glu Gly Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln 
1               5                   10                  15      


Asp Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val 
            20                  25                  30          


Ala Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser 
        35                  40                  45              


Leu Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Ser Thr Gln His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys 
                85                  90                  95      


Ile Val Val Val Trp Val Gly Thr Asn Asn His Ser His Thr Ala Glu 
            100                 105                 110         


Gln Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Lys Leu 
        115                 120                 125             


Gln Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln 
    130                 135                 140                 


His Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Val 
145                 150                 155                 160 


Arg Ala Ala Leu Ala Gly Tyr Pro Arg Ala His Phe Leu Asp Ala Asp 
                165                 170                 175     


Pro Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr 
            180                 185                 190         


Asp Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala 
        195                 200                 205             


Leu His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly 
    210                 215                 220                 


Ile Pro Leu Pro Glu Thr Ala Ser 
225                 230         


<210>  268
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Lys His Ile Asn Leu Ser Phe Ala Ala Cys Gly Phe Leu Gly Ile 
1               5                   10                  15      


Tyr His Leu Gly Ala Ala Ser Ala Leu Cys Arg His Gly Lys Lys Leu 
            20                  25                  30          


Val Lys Asp Val Lys Ala Phe Ala Gly Ala Ser Ala Gly Ser Leu Val 
        35                  40                  45              


Ala Ser Val Leu Leu Thr Ala Pro Glu Lys Ile Glu Glu Cys Asn Gln 
    50                  55                  60                  


Phe Thr Tyr Lys Phe Ala Glu Glu Ile Arg Arg Gln Ser Phe Gly Ala 
65                  70                  75                  80  


Val Thr Pro Gly Tyr Asp Phe Met Ala Arg Leu Arg Ser Gly Met Glu 
                85                  90                  95      


Ser Ile Leu Pro Pro Ser Ala His Glu Leu Ala Gln Asn Arg Leu His 
            100                 105                 110         


Val Ser Ile Thr Asn Ala Lys Thr Arg Glu Asn His Leu Val Ser Thr 
        115                 120                 125             


Phe Ser Ser Arg Glu Asp Leu Ile Lys Val Leu Leu Ala Ser Ser Phe 
    130                 135                 140                 


Val Pro Ile Tyr Ala Gly Leu Lys Leu Val Glu Tyr Lys Gly Gln Lys 
145                 150                 155                 160 


Trp Val Asp Gly Gly Leu Thr Asn Ala Leu Pro Ile Leu Pro Val Gly 
                165                 170                 175     


Arg Thr Val Thr Ile Ser Pro Phe Ser Gly Arg Leu Asp Ile Ser Pro 
            180                 185                 190         


Gln Asp Lys Gly Gln Leu Asp Leu Tyr Val Asn Ile Ala Lys Gln Asp 
        195                 200                 205             


Ile Met Leu Ser Leu Ala Asn Leu Val Arg Leu Asn Gln Ala Leu Phe 
    210                 215                 220                 


Pro Pro Ser Lys Arg Lys Met Glu Ser Leu Tyr Gln Cys Gly Phe Asp 
225                 230                 235                 240 


Asp Thr Val Lys Phe Leu Leu Lys Glu Asn Trp Phe Glu 
                245                 250             


<210>  269
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Asn 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro 
                325         


<210>  270
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe 
1               5                   10                  15      


Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro 
            20                  25                  30          


Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Ser Phe Asp Tyr Asp 
        35                  40                  45              


His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Thr Phe Asp Gln Leu 
    50                  55                  60                  


Thr Pro Glu Glu Ser Lys Glu Arg Leu Gly Lys Ile Val Ser Lys Ile 
65                  70                  75                  80  


Asp Gly Asp Lys Asp Gly Phe Val Thr Val Asp Glu Leu Lys Asp Trp 
                85                  90                  95      


Ile Lys Phe Ala Gln Lys Arg Trp Ile Tyr Glu Asp Val Glu Arg Gln 
            100                 105                 110         


Trp Lys Gly His Asp Leu Asn Glu Asp Gly Leu Val Ser Trp Glu Glu 
        115                 120                 125             


Tyr Lys Asn Ala Thr Tyr Gly Tyr Val Leu Asp Asp Pro Asp Pro Asp 
    130                 135                 140                 


Asp Gly Phe Asn Tyr Lys Gln Met Met Val Arg Asp Glu Arg Arg Phe 
145                 150                 155                 160 


Lys Met Ala Asp Lys Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe 
                165                 170                 175     


Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val 
            180                 185                 190         


Val Gln Glu Thr Met Glu Asp Ile Asp Lys Asn Ala Asp Gly Phe Ile 
        195                 200                 205             


Asp Leu Glu Glu Tyr Ile Gly Asp Met Tyr Ser His Asp Gly Asn Thr 
    210                 215                 220                 


Asp Glu Pro Glu Trp Val Lys Thr Glu Arg Glu Gln Phe Val Glu Phe 
225                 230                 235                 240 


Arg Asp Lys Asn Arg Asp Gly Lys Met Asp Lys Glu Glu Thr Lys Asp 
                245                 250                 255     


Trp Ile Leu Pro Ser Asp Tyr Asp His Ala Glu Ala Glu Ala Arg His 
            260                 265                 270         


Leu Val Tyr Glu Ser Asp Gln Asn Lys Asp Gly Lys Leu Thr Lys Glu 
        275                 280                 285             


Glu Ile Val Asp Lys Tyr Asp Leu Phe Val Gly Ser Gln Ala Thr Asp 
    290                 295                 300                 


Phe Gly Glu Ala Leu Val Arg His Asp Glu Phe 
305                 310                 315 


<210>  271
<211>  224
<212>  PRT
<213>  Bos taurus

<400>  271

Met Pro Gly Gly Leu Leu Leu Gly Asp Glu Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Ile Gly Arg Ile Arg Phe His Asp Tyr Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Met Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Gly Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Lys Asn Arg Asp Leu Ala Ile 
            100                 105                 110         


Gln Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Ile Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Ile Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asn Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  272
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Ala Lys Ile Ser Ser Pro Thr Glu Thr Glu Arg Cys Ile Glu Ser 
1               5                   10                  15      


Leu Ile Ala Val Phe Gln Lys Tyr Ala Gly Lys Asp Gly Tyr Asn Tyr 
            20                  25                  30          


Thr Leu Ser Lys Thr Glu Phe Leu Ser Phe Met Asn Thr Glu Leu Ala 
        35                  40                  45              


Ala Phe Thr Lys Asn Gln Lys Asp Pro Gly Val Leu Asp Arg Met Met 
    50                  55                  60                  


Lys Lys Leu Asp Thr Asn Ser Asp Gly Gln Leu Asp Phe Ser Glu Phe 
65                  70                  75                  80  


Leu Asn Leu Ile Gly Gly Leu Ala Met Ala Cys His Asp Ser Phe Leu 
                85                  90                  95      


Lys Ala Val Pro Ser Gln Lys Arg Thr 
            100                 105 


<210>  273
<211>  413
<212>  PRT
<213>  Rattus norvegicus

<400>  273

Met Asp Arg His Leu Cys Ile Cys Arg Glu Ile Gln Leu Arg Ser Gly 
1               5                   10                  15      


Leu Leu Phe Pro Phe Leu Leu Leu Met Met Leu Ala Asp Leu Ala Leu 
            20                  25                  30          


Pro Ala Gln Arg His Pro Pro Val Val Leu Val Pro Gly Asp Leu Gly 
        35                  40                  45              


Asn Gln Leu Glu Ala Lys Leu Asp Lys Pro Lys Val Val His Tyr Leu 
    50                  55                  60                  


Cys Ser Lys Arg Thr Asp Ser Tyr Phe Thr Leu Trp Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Leu Leu Pro Val Ile Ile Asp Cys Trp Ile Asp Asn Ile Arg Leu 
                85                  90                  95      


Val Tyr Asn Arg Thr Ser Arg Thr Thr Gln Phe Pro Asp Gly Val Asp 
            100                 105                 110         


Val Arg Val Pro Gly Phe Gly Glu Thr Phe Ser Leu Glu Phe Leu Asp 
        115                 120                 125             


Pro Ser Lys Arg Asn Val Gly Ser Tyr Phe Tyr Thr Met Val Glu Ser 
    130                 135                 140                 


Leu Val Gly Trp Gly Tyr Thr Arg Gly Glu Asp Val Arg Gly Ala Pro 
145                 150                 155                 160 


Tyr Asp Trp Arg Arg Ala Pro Asn Glu Asn Gly Pro Tyr Phe Leu Ala 
                165                 170                 175     


Leu Gln Glu Met Ile Glu Glu Met Tyr Gln Met Tyr Gly Gly Pro Val 
            180                 185                 190         


Val Leu Val Ala His Ser Met Gly Asn Met Tyr Met Leu Tyr Phe Leu 
        195                 200                 205             


Gln Arg Gln Pro Gln Ala Trp Lys Asp Lys Tyr Ile Gln Ala Phe Val 
    210                 215                 220                 


Ser Leu Gly Ala Pro Trp Gly Gly Val Ala Lys Thr Leu Arg Val Leu 
225                 230                 235                 240 


Ala Ser Gly Asp Asn Asn Arg Ile Pro Val Ile Gly Pro Leu Lys Ile 
                245                 250                 255     


Arg Glu Gln Gln Arg Ser Ala Val Ser Thr Ser Trp Leu Leu Pro Tyr 
            260                 265                 270         


Asn His Thr Trp Ser His Glu Lys Val Phe Val Tyr Thr Pro Thr Ala 
        275                 280                 285             


Asn Tyr Thr Leu Arg Asp Tyr His Arg Phe Phe Gln Asp Ile Gly Phe 
    290                 295                 300                 


Glu Asp Gly Trp Phe Met Arg Gln Asp Thr Gln Gly Leu Val Glu Ala 
305                 310                 315                 320 


Leu Val Pro Pro Gly Val Glu Leu His Cys Leu Tyr Gly Thr Gly Val 
                325                 330                 335     


Pro Thr Pro Asn Ser Phe Tyr Tyr Glu Asn Phe Pro Asp Arg Asp Pro 
            340                 345                 350         


Lys Ile Cys Phe Gly Asp Gly Asp Gly Thr Val Asn Leu Glu Ser Val 
        355                 360                 365             


Leu Gln Cys Gln Ala Trp Gln Ser Arg Gln Glu His Lys Val Ser Leu 
    370                 375                 380                 


Gln Glu Leu Pro Gly Ser Glu His Ile Glu Met Leu Ala Asn Ala Thr 
385                 390                 395                 400 


Thr Leu Ala Tyr Leu Lys Arg Val Leu Leu Glu Glu Pro 
                405                 410             


<210>  274
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Ser Ile Asn Leu Thr Val Asp Ile Tyr Ile Tyr Leu Leu Ser Tyr 
1               5                   10                  15      


Ala Arg Ser Val Cys Gly Lys Gln Arg Ser Lys Gln Leu Tyr Phe Leu 
            20                  25                  30          


Phe Ser Pro Lys His Tyr Trp Arg Ile Ser His Ile Ser Leu Gln Arg 
        35                  40                  45              


Gly Phe His Thr Asn Ile Ile Arg Cys Lys Trp Thr Lys Ser Glu Ala 
    50                  55                  60                  


His Ser Cys Ser Lys His Cys Tyr Ser Pro Ser Asn His Gly Leu His 
65                  70                  75                  80  


Ile Gly Ile Leu Lys Leu Ser Thr Ser Ala Pro Lys Gly Leu Thr Lys 
                85                  90                  95      


Val Asn Ile Cys Met Ser Arg Ile Lys Ser Thr Leu Asn Ser Val Ser 
            100                 105                 110         


Lys Ala Val Phe Gly Asn Gln Asn Glu Met Ile Leu Arg Leu Ala Gln 
        115                 120                 125             


Phe Lys Pro Ser Ser Gln Ile Leu Arg Lys Val Ser Asp Ser Gly Trp 
    130                 135                 140                 


Leu Lys Gln Lys Asn Ile Lys Gln Ala Ile Lys Ser Leu Lys Lys Tyr 
145                 150                 155                 160 


Ser Asp Lys Ser Ala Glu Lys Ser Pro Phe Pro Glu Glu Lys Ser His 
                165                 170                 175     


Ile Ile Asp Lys Glu Glu Asp Ile Gly Lys Arg Ser Leu Phe His Tyr 
            180                 185                 190         


Thr Ser Ser Ile Thr Thr Lys Phe Gly Asp Ser Phe Tyr Phe Leu Ser 
        195                 200                 205             


Asn His Ile Asn Ser Tyr Phe Lys Arg Lys Glu Lys Met Ser Gln Gln 
    210                 215                 220                 


Lys Glu Asn Glu His Phe Arg Asp Lys Ser Glu Leu Glu Asp Lys Lys 
225                 230                 235                 240 


Val Glu Glu Gly Lys Leu Arg Ser Pro Asp Pro Gly Ile Leu Ala Tyr 
                245                 250                 255     


Lys Pro Gly Ser Glu Ser Val His Thr Val Asp Lys Pro Thr Ser Pro 
            260                 265                 270         


Ser Ala Ile Pro Asp Val Leu Gln Val Ser Thr Lys Gln Ser Ile Ala 
        275                 280                 285             


Asn Phe Leu Ser Arg Pro Thr Glu Gly Val Gln Ala Leu Val Gly Gly 
    290                 295                 300                 


Tyr Ile Gly Gly Leu Val Pro Lys Leu Lys Tyr Asp Ser Lys Ser Gln 
305                 310                 315                 320 


Ser Glu Glu Gln Glu Glu Pro Ala Lys Thr Asp Gln Ala Val Ser Lys 
                325                 330                 335     


Asp Arg Asn Ala Glu Glu Lys Lys Arg Leu Ser Leu Gln Arg Glu Lys 
            340                 345                 350         


Ile Ile Ala Arg Val Ser Ile Asp Asn Arg Thr Arg Ala Leu Val Gln 
        355                 360                 365             


Ala Leu Arg Arg Thr Thr Asp Pro Lys Leu Cys Ile Thr Arg Val Glu 
    370                 375                 380                 


Glu Leu Thr Phe His Leu Leu Glu Phe Pro Glu Gly Lys Gly Val Ala 
385                 390                 395                 400 


Val Lys Glu Arg Ile Ile Pro Tyr Leu Leu Arg Leu Arg Gln Ile Lys 
                405                 410                 415     


Asp Glu Thr Leu Gln Ala Ala Val Arg Glu Ile Leu Ala Leu Ile Gly 
            420                 425                 430         


Tyr Val Asp Pro Val Lys Gly Arg Gly Ile Arg Ile Leu Ser Ile Asp 
        435                 440                 445             


Gly Gly Gly Thr Arg Gly Val Val Ala Leu Gln Thr Leu Arg Lys Leu 
    450                 455                 460                 


Val Glu Leu Thr Gln Lys Pro Val His Gln Leu Phe Asp Tyr Ile Cys 
465                 470                 475                 480 


Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Leu Gly Leu Phe His 
                485                 490                 495     


Met Pro Leu Asp Glu Cys Glu Glu Leu Tyr Arg Lys Leu Gly Ser Asp 
            500                 505                 510         


Val Phe Ser Gln Asn Val Ile Val Gly Thr Val Lys Met Ser Trp Ser 
        515                 520                 525             


His Ala Phe Tyr Asp Ser Gln Thr Trp Glu Asn Ile Leu Lys Asp Arg 
    530                 535                 540                 


Met Gly Ser Ala Leu Met Ile Glu Thr Ala Arg Asn Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Val Ala Ala Val Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys 
                565                 570                 575     


Ala Phe Val Phe Arg Asn Tyr Gly His Phe Pro Gly Ile Asn Ser His 
            580                 585                 590         


Tyr Leu Gly Gly Cys Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser 
        595                 600                 605             


Ser Ala Ala Pro Gly Tyr Phe Ala Glu Tyr Ala Leu Gly Asn Asp Leu 
    610                 615                 620                 


His Gln Asp Gly Gly Leu Leu Leu Asn Asn Pro Ser Ala Leu Ala Met 
625                 630                 635                 640 


His Glu Cys Lys Cys Leu Trp Pro Asp Val Pro Leu Glu Cys Ile Val 
                645                 650                 655     


Ser Leu Gly Thr Gly Arg Tyr Glu Ser Asp Val Arg Asn Thr Val Thr 
            660                 665                 670         


Tyr Thr Ser Leu Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr 
        675                 680                 685             


Asp Thr Glu Glu Val His Ile Met Leu Asp Gly Leu Leu Pro Pro Asp 
    690                 695                 700                 


Thr Tyr Phe Arg Phe Asn Pro Val Met Cys Glu Asn Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Ser Arg Asn Glu Lys Leu Asp Gln Leu Gln Leu Glu Gly Leu Lys 
                725                 730                 735     


Tyr Ile Glu Arg Asn Glu Gln Lys Met Lys Lys Val Ala Lys Ile Leu 
            740                 745                 750         


Ser Gln Glu Lys Thr Thr Leu Gln Lys Ile Asn Asp Trp Ile Lys Leu 
        755                 760                 765             


Lys Thr Asp Met Tyr Glu Gly Leu Pro Phe Phe Ser Lys Leu 
    770                 775                 780         


<210>  275
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


Gln Leu Leu Leu Ser Pro 
                805     


<210>  276
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Pro His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Ser Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn 
545                 550                 555                 560 


Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  277
<211>  103
<212>  PRT
<213>  Sus scrofa

<400>  277

Met Thr Ser Lys Leu Ala Val Ala Phe Leu Ala Val Phe Leu Leu Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Ala Ala Val Leu Ala Arg Val Ser Ala Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Asn Thr His Ser Thr Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Glu Asn Ser 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Val Asn Gly Lys Glu Val Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Lys Trp Val Gln Lys Val Val Gln Ile Phe Leu Lys Arg Thr 
                85                  90                  95      


Glu Lys Gln Gln Gln Gln Gln 
            100             


<210>  278
<211>  70
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  278

Gly Ile Cys Pro Arg Phe Ala His Val Ile Glu Asn Leu Leu Leu Gly 
1               5                   10                  15      


Thr Pro Ser Ser Tyr Glu Thr Ser Leu Lys Glu Phe Glu Pro Asp Asp 
            20                  25                  30          


Thr Met Lys Asp Ala Gly Met Gln Met Lys Lys Val Leu Asp Ser Leu 
        35                  40                  45              


Pro Gln Thr Thr Arg Glu Asn Ile Met Lys Leu Thr Glu Lys Ile Val 
    50                  55                  60                  


Lys Ser Pro Leu Cys Met 
65                  70  


<210>  279
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  279

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  280
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  280

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ser Leu Thr Asp Tyr 
            20                  25                  30          


Val Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
        35                  40                  45              


Asn Val Ser Asn Arg Thr Trp Asp Cys Val Leu Val Ser Pro Arg Asn 
    50                  55                  60                  


Pro Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe Gln Gln Phe Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Val Gln Val Leu His Val Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Ala Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn 
        195                 200                 205             


Ala Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Lys Met Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile 
                245                 250                 255     


His Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asp Val Asp Ser Thr Ser Ser Ser Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Val Met Val Leu 
                325                 330                 335     


Leu Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Ala Leu Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met Pro Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Ser His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Val Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Asn 
545                 550                 555                 560 


Gln Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys 
    610                 615                 620                 


Gly Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210>  281
<211>  547
<212>  PRT
<213>  Macaca fascicularis

<400>  281

Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser Met Asp 
1               5                   10                  15      


Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu 
            20                  25                  30          


His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys Arg Gly 
        35                  40                  45              


Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala Leu His Val 
    50                  55                  60                  


Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu Leu Thr His 
65                  70                  75                  80  


Gly Ala Asn Ala Asp Ala His Gly Glu His Gly Asn Thr Pro Leu His 
                85                  90                  95      


Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala Leu Ile Val 
            100                 105                 110         


Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro Thr 
        115                 120                 125             


Phe Leu Ala Ser Lys Ile Ser Arg Leu Asp Thr Arg Lys Ala Ile Leu 
    130                 135                 140                 


Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Ser Pro Pro Ile His 
145                 150                 155                 160 


Gly Val Pro Ala Glu Gln Gly Phe Ala Ala Pro His His Pro Phe Ser 
                165                 170                 175     


Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn Leu Glu Leu 
            180                 185                 190         


Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu 
        195                 200                 205             


Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu 
    210                 215                 220                 


Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala 
225                 230                 235                 240 


Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val 
                245                 250                 255     


Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Gly 
            260                 265                 270         


Lys Ser Met Ala Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu 
        275                 280                 285             


Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe 
    290                 295                 300                 


Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys 
305                 310                 315                 320 


Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu 
                325                 330                 335     


Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro 
            340                 345                 350         


Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp 
        355                 360                 365             


Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr 
    370                 375                 380                 


Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Glu Leu Leu Ala Asn Asn 
385                 390                 395                 400 


Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu 
                405                 410                 415     


Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val 
            420                 425                 430         


Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp 
        435                 440                 445             


Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly 
    450                 455                 460                 


Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp 
465                 470                 475                 480 


Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile 
                485                 490                 495     


Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp 
            500                 505                 510         


Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val 
        515                 520                 525             


Tyr Ile Tyr Glu His His Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu 
    530                 535                 540                 


Leu Ser Pro 
545         


<210>  282
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys 
                965             


<210>  283
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro 
                325         


<210>  284
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  285
<211>  224
<212>  PRT
<213>  Bos taurus

<400>  285

Met Pro Gly Gly Leu Leu Leu Gly Asp Glu Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Ile Gly Arg Ile Arg Phe His Asp Tyr Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Met Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Gly Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Lys Asn Arg Asp Leu Ala Ile 
            100                 105                 110         


Gln Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Ile Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Ile Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asn Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  286
<211>  229
<212>  PRT
<213>  Mus musculus

<400>  286

Met Ser Gln Gly Asp Ser Asn Pro Ala Ala Ile Pro His Ala Ala Glu 
1               5                   10                  15      


Asp Ile Gln Gly Asp Asp Arg Trp Met Ser Gln His Asn Arg Phe Val 
            20                  25                  30          


Leu Asp Cys Lys Asp Lys Glu Pro Asp Val Leu Phe Val Gly Asp Ser 
        35                  40                  45              


Met Val Gln Leu Met Gln Gln Tyr Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Thr Thr Arg His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Lys Asn Gly Glu Leu Glu Asn Ile Lys Pro Lys 
                85                  90                  95      


Val Ile Val Val Trp Val Gly Thr Asn Asn His Glu Asn Thr Ala Glu 
            100                 105                 110         


Glu Val Ala Gly Gly Ile Glu Ala Ile Val Gln Leu Ile Asn Thr Arg 
        115                 120                 125             


His Ala Gln Ala Lys Ile Ile Val Leu Gly Leu Leu Pro Arg Gly Glu 
    130                 135                 140                 


Lys Pro Asn Pro Leu Arg Gln Lys Asn Ala Lys Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Val Ser Leu Pro Lys Leu Ala Asn Val Gln Leu Leu Asp Ile Asp 
                165                 170                 175     


Gly Gly Phe Val His Ser Asp Gly Ala Ile Ser Cys His Asp Met Phe 
            180                 185                 190         


Asp Phe Leu His Leu Thr Gly Gly Gly Tyr Ala Lys Ile Cys Lys Pro 
        195                 200                 205             


Leu His Glu Leu Ile Met Gln Leu Leu Glu Glu Thr Pro Gly Glu Lys 
    210                 215                 220                 


Gln Thr Thr Ile Ala 
225                 


<210>  287
<211>  232
<212>  PRT
<213>  Mus musculus

<400>  287

Met Ser Gly Glu Gly Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln 
1               5                   10                  15      


Asp Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val 
            20                  25                  30          


Ala Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser 
        35                  40                  45              


Leu Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser 
    50                  55                  60                  


Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Ser Thr Gln His 
65                  70                  75                  80  


Val Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys 
                85                  90                  95      


Ile Val Val Val Trp Val Gly Thr Asn Asn His Ser His Thr Ala Glu 
            100                 105                 110         


Gln Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Lys Leu 
        115                 120                 125             


Gln Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln 
    130                 135                 140                 


His Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Val 
145                 150                 155                 160 


Arg Ala Ala Leu Ala Gly Tyr Pro Arg Ala His Phe Leu Asp Ala Asp 
                165                 170                 175     


Pro Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr 
            180                 185                 190         


Asp Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala 
        195                 200                 205             


Leu His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly 
    210                 215                 220                 


Ile Pro Leu Pro Glu Thr Ala Ser 
225                 230         


<210>  288
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  289
<211>  15715
<212>  DNA
<213>  Homo sapiens

<400>  289
aagcgcgtcg ccaccgcccc cgcctaggcg agagcccaga gagctgaacc tgcatcccgg       60

acctgcggcg accgtcgtac accatgggcc tccacctccg cccctaccgt gtggggctgc      120

tcccggatgg cctcctgttc ctcttgctgc tgctaatgct gctcgcggac ccagcgctcc      180

cggccggacg tcacccccca gtggtgctgg gtgaggcacg ggtctcgtgg tggatctgtc      240

ggtcgggcgg gacgggccgc gggcggggct gccttcccgg tctgcttctg ttccagtcac      300

gaaatggggg agcgtattgg tatctgtctt gtcacttagg tgatctagat ctgccggctc      360

acctcccgcc atgctgggcg cgggtgtggt cagctcccca cctcctgtcc tggtagaaaa      420

tgggggtgag tgggagagtt accatctggt tattcatagt tccacctgtc cgcatcattc      480

ccaagccttg cctcccctta tcccattttt aagctggaaa gacaggtgct tcagccccac      540

tcctgaggga tggtgggggt gtgtagagtg gctcctgagt tgacttctgc atcgacctgg      600

gcctggttag gaggctgtca ccctcgaccc ctccaatgcc acatatgcca gaaggcattg      660

ctgaaaggaa cctccttagg gaaaggattg ctgtcctagc tggccaccaa ctcccacaac      720

ttatcagatg tgtggcattg cctgagggaa aaggcctaag ggaaactgaa gacaactgaa      780

gtcaggggaa agggttggga caatggccat gaacctgtgt caggcaacat gcttgtactc      840

ttaccctgcc acacatgctt ggactagact atgtggaggc tcggtgacct cccctgctca      900

ccccgctcct tgatcacaac cctggcaact ctacaacggc cactgtattt ccttgcaggg      960

atgggcaggg atgagacctc tgtctggggg gccttgggtg cctcattgag gccgtcactc     1020

ccatccagag ctggtgtgtc cgtggccagc caggattcct gaaagcagag gcatctgagg     1080

catgaattac acgtggagtc tagtgcagca tgatctccat gctctttctg ctgagagtac     1140

tttaaatggg gacgatgcaa atcacagaag ggtagagttg gcaggtaggg tggtgccagg     1200

caggccccac caggagttcc cagccaggaa aagctccagg gggatactag gcccaggttc     1260

accatgggat ttgggcagac ttggccctgc ctccccaaag cttgcaggat aggaataaca     1320

gtgatcccca gagaggaagt ctgtgtgggg caagcacaga gaatccacca acccagcctg     1380

gatgggtggg tgtcaagtaa ggcttcctgg agtatatagc tggagctaag gccaggagag     1440

agtaatgggt cggggagaga cgtgagcatc tcaggctgcc tgggatcgag tcacaggagg     1500

agtggactgc acaggacttg tgactggttg ggtcatctga actttatctt gagggcctca     1560

gggagtcctg ggttggcctg cagagttcta agtctgaggg gcgtggcatt aggaagcatg     1620

tggtctgtgg cacacaaaat ggcacatagc cattttgcct ggattgatgc taaccgcact     1680

catcaattca gtcagtctgt ttatccttgg tcacagcaga agagcctcag accccaccca     1740

gaatcacaga gcagcaggag tcctaacatg cccagcttct cagggagtga ggctgctggc     1800

cttagccctg ggagacctca cggtgggcag ttggataagc agctcctggg cacagagcag     1860

ggatctgacc ttgactgtca gaagatcaga atcctctagg ggtggatcct gaaatggtgg     1920

tggaggaaag agagaccagc gatgtgatac agaagaccct gggcaagggg aagggaccat     1980

aggcaaggcc atttccacct cttgcagcct cagtctcccc atctgttaag tggaaatagt     2040

aaggctgtcc cctcccagtg ttacttgagg tgaaaggcat gtggatggct cttttcctag     2100

ttccaggcgc agatgggctc aggaagtggc cactgctatt tttaggggcc acacagcctg     2160

accagggtaa ggagcatctg agcaaagcag atctggtgac ttcctctttt accatttccc     2220

ctttggtaga gacagtgacc agggtctctg ccctgccctg cccagtccac aggcatgtca     2280

tccagaggct gtcatgacag ggactccctc cctctgcacc cataccatga agggaggtga     2340

aggcatgtgc cgcccctgcc tctcatggca ccctgaagac actgggatgg tgcccaggga     2400

gggcacgccc tgttcagggt ggatttacgg tcagttccca gtgaatgtcc aggagagcca     2460

agtgctggtt tttcactcaa tgatcatgga ccctaaacgg ggatgtgttt gggaagtggc     2520

gagagcatgg catgtggggg caggtgaggc ccgaaaggtc aatgggagta acgagactgt     2580

gaagggcttt gacgcagtgg ggagggattt gggtgtcacc agggccccag agttctgagt     2640

acactgaata ggatggctgg gatggagaga agtcacccta gggcctggac tgtggtgata     2700

atggtgctgg ttcagggtgg ctgtttccaa tacgggctcc cagccatgct agggccctcc     2760

agatgatctg ctctctggca ccttactgga ctctggcctt tagtaaggcc tgggcccttg     2820

gtaggctggc gggtgccaat gtaagcttct ctcagctgtg tttctgttca tttccctccc     2880

accagcctgt cctgcatact ttgtctggtt gaattttagc tgagtggccc agggctctgt     2940

tctgtttcct tcttcctctc tcagggcgaa caggaccctg tcttctatgt agcctgggat     3000

agctatgggt ggaagacttt tgggttcaag cctccagggt atatatcttt tttttttttt     3060

gagaccgggt cttgctctgt cacccaggct ggagggcaat ggcacgattt tggctcactg     3120

caacctctgc ctcccgggtt caagcaattc tcctgtctta ggctcctgag tagctgggat     3180

tacaggtgtg tgccaccaca ccaaggtaat tttttgtatt tttagtagag atgggctttc     3240

accatattgg ccaagctggt cttgaactcc tgaccgcaag tgatccactc acctcggcct     3300

cccaaagtgc tgggattaca ggcatgagcc cctgcgccct gcctcgaagg tatatatcta     3360

atgacaaggg ccttggccaa actttggagg ttctggaatg caaaggggtc tccaagcccc     3420

tcctcccagg cagagctccc atcggggtcc attaaccata gaaaccatgt gtagaggtgt     3480

gtctgtgttt gctgggggtg attcagacca agatctcatt taacagatac ggaaactgag     3540

gcctagtgtg gggagtgact tcaccctgaa cccccttcca ataatctgaa tggcccagga     3600

ggatgttcca gtgaaaatcc aggagactta ctttatctgg agttggagac aatgttaggg     3660

cccttcccca aacatgtcag gcctctccca agccccccac aggcatctct gcaccacaca     3720

gcagtagcag cttttctgca caaagatggt tccctggcct ttgggtcaag gtccctgctc     3780

tctgaatttc ctgccaccag cactgtgctt taatttgaga tgtggaactg cacaggtctg     3840

ccatattatc tgtggctctt cagggggtct gctgcagaca tcaaagttct tgggagtctt     3900

gaacctgccg ggctgagggc tcacacatgt cctgtgcccc ctgcagtccc tggtgatttg     3960

ggtaaccaac tggaagccaa gctggacaag ccgacagtgg tgcactacct ctgctccaag     4020

aagaccgaaa gctacttcac aatctggctg aacctggaac tgctgctgcc tgtcatcatt     4080

gactgctgga ttgacaatat caggtggggg ctggggcaca cagagggggg tgctgctcac     4140

caacagtgcc tgagaggcct ccagagtctg ttccttctat cctcatctcg aggtcactga     4200

cctctctcct tccccaggtc ctcggtctgg tctggtctgg tctggttggc accacctctg     4260

cactcccagg cagaactaac tttcccttcc tgctgccctt gttcctctac tctccagtcc     4320

tggcctctca tgcctacaca caattttttt tttcttttat tttgggatgg agtcttgctg     4380

tgtcactcag gctggcgcca tctcagctca ctgcaacctc cgtctcccag gttcaagcga     4440

ttcttgtgcc tcagcctccc aagtagctgg gattacaggt gcccgccacc atgcctggct     4500

aattttttgt atttttagtg gagatggtgt ttcaccatgt tggccatgct ggtcttgaac     4560

tcctgagctc aagtgttctg cccaccttgg actcccaaag tgctgggatt acaggcatga     4620

gccactacgc ctgcctacac aaaatttctg tgtcccagcc cctattcaga gcctcggcat     4680

ggcccccacc cctttccttg tctgtgcctc ggcctcccct acctctccag ctgcttattc     4740

ttcttgggac atgccatgtc tttgtacctg ctgttctttt ggcctggaat ctatttctac     4800

accctttgcc tgataaatgg cttccattca cttttttttt tttttttttt tttggagacg     4860

gagttttgct cttattgccc aggctggagt gcaatggcgc gatctcggct cacaactctt     4920

tttttttttt ttaactttta ttttttgaga cagagtcttg ctctgtcgcc caggctgggt     4980

gcagtggcgc tatctcggct cactgcaagc tccgcctccc gggttcacgc cattcttctg     5040

cctcagcctc ccaagtagct gggaccacag gcgcccgcca cagtgcccgg ctaatttttt     5100

gtatttttta gtagagacag ggtttcaccg tgttaaccag gatggtctcc atctactgac     5160

cttgtgatcc gcctgcctca gcctcccaaa gtgctgggat tacaggcgtg agccaccaca     5220

cccagcccca ttcactcttt aaaacatgac cctaggccag gcatggtggc tctgctataa     5280

tcccatcact ttgggaggct gaggcagtca gatcacctga gctcaggagt tgaagaccag     5340

cctgggcaac ttggtgaaac cccatctcta ccaaaaatac aaaaaaatta gctgggcatg     5400

gtggcatgca cctgtagtcc cagctactta gggggctgag gcaggagaat tgcttgagcc     5460

agggaagcag aggttgcagt gagcagacca ctgtacccag cctgggttgc agagcaagac     5520

cctgtctcaa aacaacaaaa acctgaccct ggtccctttg tgacatgtcc cttttgactc     5580

cccagagcgg tttgcctctc ctcccaggcc ccatgcttgc ttcctctaaa catcatcatg     5640

tgcccgaatt tgtctgcagg catgtttgcc caaattgcac aggcactgta cattttatat     5700

actttctttc agttagtctt acagcaaccc cgttttgaaa taggtgctgt tttctttttt     5760

tttttttcac cagtgttact tgccaacagg tggtttttaa acctgcttta caactgcgaa     5820

atctggaggc tcaatgaggt tacaaaattg actgtgctca ctcagctaat aagtggtaga     5880

atcagaattc aaatccagaa tgtgtggcgt tgagctgagg ttccctccca ggctgagttc     5940

cgtgaaggga gggagtgtgt gtctgtttta tccttatagc agtagaacca gaaacacagt     6000

tggcgcctga taaatgtttg agctgaatgg agtctcccaa attaaaagtt tttcctggtc     6060

gggtgcggtg gctcatgcct gtaatcccag cactttggga ggctgaggtg gacagatcat     6120

gaggtcagga gttcgagact agcccggcca acacagtgaa accctgtctc tactaaaaat     6180

gcaaaaatta aggccgggca tggtggctca cgcctgtaat cccagctagt caggagtctg     6240

aggcaggaga aacgcttgaa cctgggtggt ggaagttgca gtgagctgag atcgtgccat     6300

tgtactccag cccaggtgac agtacaagac tccatctcaa aaaaaagaaa atacaaaaat     6360

acaaaaatga gccgggcgtg gtggcacacg cccatgatcc cagctactcg ggaggctgag     6420

acaggagaat cacttgaacc tgggaggcag aggttgcagt gagcagagat gggggcactg     6480

cactctagcc tgggtgacag agcgagactg tctcaaaaaa aaaaaaaaaa aaaagttttt     6540

cccagagacc cgctagctgc tcctccaggt gccctggcct gccggctgtt tgtgatgccc     6600

attttgatga ctccttcctc ctctgtgtgt tgtgtgactg gggttatttc tgggctgttg     6660

atgtgcattt ctatttttat actggggaca cagcctcagg tgctgccagt tggaggtgcc     6720

agctgatacc aagaggggcc tgtctgcctt cactgcttct ctgacccgtt tagattttca     6780

cccagcgcag aactgctttg gctttccaga acagttttct gcattttgct gtttgataat     6840

ttatttttag tagcaacaag ctactttgct atgtggtcat tgggataatc tacaaattgc     6900

cctggagaga atgggcctcc aggacctgtt atctgggtca gttgtgggga tcctgtcagc     6960

ttcagtggct gatatctaag tgggcaagtg ggactcagga ccaccagaaa ctccaggttc     7020

ctgtgttttg ggggcacatt tgcttcttca gtgtgtggcg aggccagagc aaggttccca     7080

gcctcgcaca gaggcacaag gcttttctcc tggtataagg tgtctcccct ggcccatcac     7140

cctgttccca tcatttcttc aggccttgac aaccctcttc ccacaggaga tggtgcagca     7200

gctgtgtact gagccctgag gcggggtctg tcctgtctgg ttctgtttgg cactgcagct     7260

acagaaacta tgagatcacg tgtgtggtgt tagaagctgc tgagtctgtg gtaatttatt     7320

acacagttct agaaaactaa taggctgggt gcagtggctc acacctataa tcccagcact     7380

ttgggaggct aaggcaggag gatcgcttga gcccaggagt ttgagaccag catgagcaca     7440

tagtgtggcc ctgtccctac aaaataaata aacaaataaa taaataaatt agccagacct     7500

ggtggtgcct gcctagctgt tcaggagggt gaggtaagag gatcacttga gcccaggagg     7560

ttatggctac agtgagctat gatctcctca ctgtgctgca gcctgggcaa cagagtgaga     7620

ccctgtctca aaaaagaaga agaaagaaaa gtaagaaagg gctgttaggg atcttaagtc     7680

agtagctggt ggtccatgtc ctatgtcatg gcgcttagga atttgctggg caagccctga     7740

gccttgtggc tgcagtctga cagttgatac agccctgggg tactgggagg tcataggagc     7800

atggttcatt cccttcctcc atggaggatg tgtttggagg ttggctggct gctgtgtcca     7860

atgcgcagag gaagcgggac ccaattatac ctacctgggg ccacacaagg ccttcctcct     7920

gtctctcccc accagctccc atcatttctc tgggccttgc tccttctcct acctgcctac     7980

ccacccatac agcagccctg aggcatggtg cctttctagg gtttgttttt gtttgtttgt     8040

ttgttttttt gagacagagt ttcgctctta ttgcccaggc tggagtgcag tggcgcaatc     8100

tcggctcact acacctctgc ctcccaggct caagcacttc tcctgcctca gactccggat     8160

aactgggatt acaggtacac gtcaccatgc ctggttaatt tttgtgtttt tagtagagat     8220

ggggtttcac cctgttggcc aggctggtct cgaactccta acctcaagtg atccacgtgc     8280

ctcagccttc caaagtgctg agattatagg cgtgagcccc tgtgcctggc ctagtgtgtt     8340

ttgttttgtt tttttttttt ttttgagaca gggtcttact ttgctgccca ggctggtgtg     8400

cagtggcatg atcacggctc actgcagcct caatatccca ggtgcaagtc atcctcctgc     8460

ctcagccttc caagtagctg ggaccacagg cctgcaccac catgcctggc taatttttta     8520

tttttagtag caacaaggcc tcactgtatt gcccaggctg gccttgaact cctggcctca     8580

agcattcctc ccaccttggc cttgcaaatt gttggaacta caggtgtcag ccactgcacc     8640

cggcccctgt ctggttctgt tgtgtactgc actcaccacc tccttcacct gggatacgtt     8700

gggctggcag gagctggatg caaggagatg gagcgatgga aagctgaaag agggtagact     8760

gcctcttggg gtccagtgtg aagttcacgg cagaatcagg actggtactt ccttctccca     8820

accaggtcca agaccctcat tctagagtag ggtcacgggg gagaggggaa tgttgctttg     8880

acaggggtcc tggggtcagt atttggagta agtatgcctt ggtggggtcc tcatttggat     8940

gtaattactc tgatctgtgc tttttatttt tatttattta tttatttatt tatttattta     9000

tttatttatt tttttgagac agagtcttgc tctgtcgccc aggctggagt gcagtggtgt     9060

gatctcagct cactacaacc tccgtgtcac aggttcaagc gattctcctg cctcagcctc     9120

ctgagtagct gggattacag tcgcctccca cgacacccgg ctgattttgt atctttagta     9180

gagatggggt ttcgccatgt ttgtcaggct ggtctcaaac tcctcactca ggtgacctgc     9240

cagcctcagc ctcccaaagt gctgggatta acaggcgtga gccactgcac ctgggcaatt     9300

tttgtatttt tagtagagac agggtttcac catattggcc aggctggttt caaactcctg     9360

acctcaagtg atcctcccac ctcagcctcc ctaagtgctg ggattacagg tgatctgtgc     9420

tttatcaacc tgctttgtta cttttcggtc tctcctatcc atctgaccaa acctgggcat     9480

gagaagggag tatgactcag gacatgatgc actgttggga cacaccaagc tcagtgtccc     9540

ctccgggtca ctggctcaat atcctctcac aacaggctgg tttacaacaa aacatccagg     9600

gccacccagt ttcctgatgg tgtggatgta cgtgtccctg gctttgggaa gaccttctca     9660

ctggagttcc tggaccccag caaaagcagc gtgggtatgt agcccttact caaggcctcc     9720

gggagctggg atggggtttc tgccggactg gagctggagc tggaggaact ctgctggttt     9780

gtagggacag cctgtgagct gtctctgatc agcgtgggca cagagccctg tagcattctt     9840

ccaaggacct gctagctgtc acagtctcca tgctgggcat agtgtaggtg gccggcacta     9900

gctgtatctt ttcttatcct ctgtatttct gtctacaggt tcctatttcc acaccatggt     9960

ggagagcctt gtgggctggg gctacacacg gggtgaggat gtccgagggg ctccctatga    10020

ctggcgccga gccccaagta agcaggcact ctcattccct ccctgacgtc tcgggaggta    10080

ggggtgaggt gatcatgggc accacagacc ttgggctctc cccttgtcct tggctgtctc    10140

ctgtccctgg gcctctggca tccagtctag tggtcacagc caccaccttt ggtcagtctt    10200

atcctgtcct ccatttccca ccctgggacc tctgggcctg tgagccctgg ggagaaatat    10260

aaggcttcct cccttcatgg aaggcggggg gacccagacc gctctgtttg aatgtgagca    10320

ccctcccctc cccctctcgt cttgtgtctg gcctgagaaa agctcagtgg ttccggctcc    10380

aggacccttc ccacctgacc cctgcctggc tctggcctgc agatgaaaac gggccctact    10440

tcctggccct ccgcgagatg atcgaggaga tgtaccagct gtatgggggc cccgtggtgc    10500

tggttgccca cagtatgggc aacatgtaca cgctctactt tctgcagcgg cagccgcagg    10560

cctggaagga caagtatatc cgggccttcg tgtcactggg tgcgccctgg gggggcgtgg    10620

ccaagaccct gcgcgtcctg gcttcaggta agaccctacc tggcccagcg tggggggctg    10680

ttgccaggaa ttctgccctc tcttcccttc ctaagtgtcc tcctgggcca gcatgcctcg    10740

tgtctgtccc acggtgtgtg gggtctatgc aaatctaccc ctaaaagtcc aaagaagaaa    10800

gaggctgaca aatctagttt ctcagagaaa agcatttaat agggacatac gaatagaagc    10860

cacatctgtg tctcaggtgg gggcaagaca agatggtgga tccccacact attagccccc    10920

agacccagag cttatattct gtagggaaag ggcgactccg atgcgatgtg ttgaacattg    10980

aaggatgata acacagaggc tgttttgatt tatggttaag tacgtgcaca agaaacagta    11040

gataaagtgg aaatctcagt ggccttcctg gatctggggt taatcagaag ccaacatggt    11100

ggattagtat ccaaaatgga gttgctttgg tctccacaat gactattctc ttgggtcagc    11160

cctgtttttt ttttaatttt tattttttga gacagagtct ggttctgtca cccagactgg    11220

aatgcagtgg tgcaatcttg tctcactgca acctctgcct cccgggttca agcgattctg    11280

cctcagcctc ctgagtagct gggattacag gtgcccgcca ccatgcctgg ctaagttttg    11340

tgttttagta gagatgaggt ttcatcatgt tggccaggct ggtcttgaac tcctgacctc    11400

agatgttcca ctcgcttcgg cctcccaaag tgctgggatt acaagtgtga gccactgtgc    11460

ctggccatcc ctccctctta ccccatcctt acttcttcat ccccaccttc accgcagagg    11520

aggaaggcta gagcattttt tttttttttt tggaggcagg gtctttctca ctctgccatc    11580

caggttggag tgcagtagcg tgattttggt tcatgcaacc tccaccttcc aggttcaagt    11640

gattctcctg cctcagcctc ccgggtaact gggactacag gcgcgtacca ccacacccgg    11700

ctaatttttg tatttttagt agagactggg tttcactatg ttggccgggc tagtctctaa    11760

ctcctgacct caagtcagga ggatctgcct gcctcagcct cccaaagtgc tgggattaca    11820

agcatgaacc accgcacccg gccagatttt tttgtatttt tagtagagat ggggtttcac    11880

cattttggtc aggctggtct tgaactcctg acctcaaatg atctgcccac cttgacctcc    11940

caaagttctg ggattacaag gatgagccac tgcacctggc ctctagacta cagtttttta    12000

tttatgagtt gcgcctccat ctgtgggcag cacggagcct ctgtaggcaa cacagggagg    12060

aagcaggtgc agatctggct gggcctgctt gcctggcaat tgggaaagcc acccctttta    12120

tggctcctcc cccgtctttt catgactgtt gcagctcacc agctgcagct gtagagtaga    12180

gcttcttcct ctagaaggga gctttcctcc ctctgctagg acttggggga ggcttatgga    12240

ccctcacttt gggagctatg agccagggct gtgccaagca tctcatgagc tcaagtgcct    12300

gccactgctt gacctgcttg gtctactggc attgtgattg ggtcaggccc agtgactctg    12360

agttggctgg aagacactca gatttagtga ggactcatta tagccaccac ttcggtctag    12420

cctgggcctg gagggacgga tgtgggcata ccctgagttt agacaggtag ccccggcccc    12480

tttcagagtt tctctgtgag tccccttaga gctttgtttc aaaggctggg aagctgttct    12540

gtcctgcctt ggcagtccag gactgggtgt gtggtgcggg gaggtggaag tccgtgcacc    12600

cctaggggct ttccttgcct caggggtccc ccagccaggc cacagcaggc agagctgagg    12660

ccctacagtc agtctgagag gcctccctgc tttcagatac agggtggggt gatgggtgac    12720

catggatcct gaacaggcca gaggcccctg ttcccaagtt gcagctttta cttcctggag    12780

gcctccctga ctgccgggtg tttgtgttgt tcacattcct gtgtataggg actccgcctc    12840

catctgcagc ctcccctcgt gccctgtctc cagcacgcct ggctgcccag gtcagcgcac    12900

atgcaagtgg gtggaatgag gccacggctg gctgaacgct ggtctgagct taggaaaaga    12960

aaaactggta cacagttcag tgtcataaaa gggaaagcag aacatgtcat ctccgagttg    13020

ccaacctgct gactcacttt agactaggtc agtgcccaca ggcctgatca gcacttggag    13080

gatggtagag tttacaggca aggaagcatc ataaatcacc ctgtgggtat gtgccgcctt    13140

actccctggt gaggaaagca aaaaaaacaa aacatagctt ggatgtgtgg ttcccagatg    13200

tagcaaaaat aaagagaaac aataaaagcc aaggcaagca aactgggcaa catagcaaga    13260

ccccatctgt ataaaaagtg gaaacatttt tagcccaggc gtggtgggac gtgcttgtag    13320

ttccagctat gcaggaggct gacataggag gatcacttga acccaggagg tggaggttgt    13380

agtgagccaa gactgtacca ctgcactcca gcctgggtga cagaatgaga ccctacttca    13440

aaaaaaaaaa aaaggaaaaa tttgccaggc atgaggcatg gtggcgcata cctgtagtcc    13500

cagctactcc aaaggctgag gcgggaggat tggttgagcc tgagaggttg aggctgctgt    13560

gagccgtgat catgccatta tactccagcc tgggcaacag agtgagaccc tgtctcaaaa    13620

agaaaaaaaa agagccaagg cagggatggg agtcacagtg attacaatga tgataaccgg    13680

gtagagatgc gggactgtgg actgggcccc tggctggggt ctggcagggg cctggtggtg    13740

aacatgctgc ccaaccagct ggcattccta agcacagact gaccagagcc ttctccctgc    13800

aggagacaac aaccggatcc cagtcatcgg gcccctgaag atccgggagc agcagcggtc    13860

agctgtctcc accagctggc tgctgcccta caactacaca tggtcacctg agaaggtgtt    13920

cgtgcagaca cccacaatca actacacact gcgggactac cgcaagttct tccaggacat    13980

cggctttgaa gatggctggc tcatgcggca ggacacagaa gggctggtgg aagccacgat    14040

gccacctggc gtgcagctgc actgcctcta tggtactggc gtccccacac cagactcctt    14100

ctactatgag agcttccctg accgtgaccc taaaatctgc tttggtgacg gcgatggtac    14160

tgtgaacttg aagagtgccc tgcagtgcca ggcctggcag agccgccagg agcaccaagt    14220

gttgctgcag gagctgccag gcagcgagca catcgagatg ctggccaacg ccaccaccct    14280

ggcctatctg aaacgtgtgc tccttgggcc ctgactcctg tgccacagga ctcctgtggc    14340

tcggccgtgg acctgctgtt ggcctctggg gctgtcatgg cccacgcgtt ttgcaaagtt    14400

tgtgactcac cattcaaggc cccgagtctt ggactgtgaa gcatctgcca tggggaagtg    14460

ctgtttgtta tcctttctct gtggcagtga agaaggaaga aatgagagtc tagactcaag    14520

ggacactgga tggcaagaat gctgctgatg gtggaactgc tgtgacctta ggactggctc    14580

cacagggtgg actggctggg ccctggtccc agtccctgcc tggggccatg tgtcccccct    14640

attcctgtgg gcttttcata cttgcctact gggccctggc cccgcagcct tcctatgagg    14700

gatgttactg ggctgtggtc ctgtacccag aggtcccagg gatcggctcc tggcccctcg    14760

ggtgaccctt cccacacacc agccacagat aggcctgcca ctggtcatgg gtagctagag    14820

ctgctggctt ccctgtggct tagctggtgg ccagcctgac tggcttcctg ggcgagccta    14880

gtagctcctg caggcagggg cagtttgttg cgttcttcgt ggttcccagg ccctgggaca    14940

tctcactcca ctcctacctc ccttaccacc aggagcattc aagctctgga ttgggcagca    15000

gatgtgcccc cagtcccgca ggctgtgttc caggggccct gatttcctcg gatgtgctat    15060

tggccccagg actgaagctg cctcccttca ccctgggact gtggttccaa ggatgagagc    15120

aggggttgga gccatggcct tctgggaacc tatggagaaa gggaatccaa ggaagcagcc    15180

aaggctgctc gcagcttccc tgagctgcac ctcttgctaa ccccaccatc acactgccac    15240

cctgccctag ggtctcacta gtaccaagtg ggtcagcaca gggctgagga tggggctcct    15300

atccaccctg gccagcaccc agcttagtgc tgggactagc ccagaaactt gaatgggacc    15360

ctgagagagc caggggtccc ctgaggcccc cctaggggct ttctgtctgc cccagggtgc    15420

tccatggatc tccctgtggc agcaggcatg gagagtcagg gctgccttca tggcagtagg    15480

ctctaagtgg gtgactggcc acaggccgag aaaagggtac agcctctagg tggggttccc    15540

aaagacgcct tcacgctgga ctgagctgct ctcccacagg gtttctgtgc agctggattt    15600

tctctgttgc atacatgcct ggcatctgtc tccccttgtt cctgagtggc cccacatggg    15660

gctctgagca ggctgtatct ggattctggc aataaaagta ctctggatgc tgtaa         15715


<210>  290
<211>  2764
<212>  DNA
<213>  Homo sapiens

<400>  290
aagcgcgtcg ccaccgcccc cgcctaggcg agagcccaga gagctgaacc tgcatcccgg       60

acctgcggcg accgtcgtac accatgggcc tccacctccg cccctaccgt gtggggctgc      120

tcccggatgg cctcctgttc ctcttgctgc tgctaatgct gctcgcggac ccagcgctcc      180

cggccggacg tcacccccca gtggtgctgg tccctggtga tttgggtaac caactggaag      240

ccaagctgga caagccgaca gtggtgcact acctctgctc caagaagacc gaaagctact      300

tcacaatctg gctgaacctg gaactgctgc tgcctgtcat cattgactgc tggattgaca      360

atatcaggct ggtttacaac aaaacatcca gggccaccca gtttcctgat ggtgtggatg      420

tacgtgtccc tggctttggg aagaccttct cactggagtt cctggacccc agcaaaagca      480

gcgtgggttc ctatttccac accatggtgg agagccttgt gggctggggc tacacacggg      540

gtgaggatgt ccgaggggct ccctatgact ggcgccgagc cccaaatgaa aacgggccct      600

acttcctggc cctccgcgag atgatcgagg agatgtacca gctgtatggg ggccccgtgg      660

tgctggttgc ccacagtatg ggcaacatgt acacgctcta ctttctgcag cggcagccgc      720

aggcctggaa ggacaagtat atccgggcct tcgtgtcact gggtgcgccc tgggggggcg      780

tggccaagac cctgcgcgtc ctggcttcag gagacaacaa ccggatccca gtcatcgggc      840

ccctgaagat ccgggagcag cagcggtcag ctgtctccac cagctggctg ctgccctaca      900

actacacatg gtcacctgag aaggtgttcg tgcagacacc cacaatcaac tacacactgc      960

gggactaccg caagttcttc caggacatcg gctttgaaga tggctggctc atgcggcagg     1020

acacagaagg gctggtggaa gccacgatgc cacctggcgt gcagctgcac tgcctctatg     1080

gtactggcgt ccccacacca gactccttct actatgagag cttccctgac cgtgacccta     1140

aaatctgctt tggtgacggc gatggtactg tgaacttgaa gagtgccctg cagtgccagg     1200

cctggcagag ccgccaggag caccaagtgt tgctgcagga gctgccaggc agcgagcaca     1260

tcgagatgct ggccaacgcc accaccctgg cctatctgaa acgtgtgctc cttgggccct     1320

gactcctgtg ccacaggact cctgtggctc ggccgtggac ctgctgttgg cctctggggc     1380

tgtcatggcc cacgcgtttt gcaaagtttg tgactcacca ttcaaggccc cgagtcttgg     1440

actgtgaagc atctgccatg gggaagtgct gtttgttatc ctttctctgt ggcagtgaag     1500

aaggaagaaa tgagagtcta gactcaaggg acactggatg gcaagaatgc tgctgatggt     1560

ggaactgctg tgaccttagg actggctcca cagggtggac tggctgggcc ctggtcccag     1620

tccctgcctg gggccatgtg tcccccctat tcctgtgggc ttttcatact tgcctactgg     1680

gccctggccc cgcagccttc ctatgaggga tgttactggg ctgtggtcct gtacccagag     1740

gtcccaggga tcggctcctg gcccctcggg tgacccttcc cacacaccag ccacagatag     1800

gcctgccact ggtcatgggt agctagagct gctggcttcc ctgtggctta gctggtggcc     1860

agcctgactg gcttcctggg cgagcctagt agctcctgca ggcaggggca gtttgttgcg     1920

ttcttcgtgg ttcccaggcc ctgggacatc tcactccact cctacctccc ttaccaccag     1980

gagcattcaa gctctggatt gggcagcaga tgtgccccca gtcccgcagg ctgtgttcca     2040

ggggccctga tttcctcgga tgtgctattg gccccaggac tgaagctgcc tcccttcacc     2100

ctgggactgt ggttccaagg atgagagcag gggttggagc catggccttc tgggaaccta     2160

tggagaaagg gaatccaagg aagcagccaa ggctgctcgc agcttccctg agctgcacct     2220

cttgctaacc ccaccatcac actgccaccc tgccctaggg tctcactagt accaagtggg     2280

tcagcacagg gctgaggatg gggctcctat ccaccctggc cagcacccag cttagtgctg     2340

ggactagccc agaaacttga atgggaccct gagagagcca ggggtcccct gaggcccccc     2400

taggggcttt ctgtctgccc cagggtgctc catggatctc cctgtggcag caggcatgga     2460

gagtcagggc tgccttcatg gcagtaggct ctaagtgggt gactggccac aggccgagaa     2520

aagggtacag cctctaggtg gggttcccaa agacgccttc acgctggact gagctgctct     2580

cccacagggt ttctgtgcag ctggattttc tctgttgcat acatgcctgg catctgtctc     2640

cccttgttcc tgagtggccc cacatggggc tctgagcagg ctgtatctgg attctggcaa     2700

taaaagtact ctggatgctg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2760

aaaa                                                                  2764


