                         SEQUENCE LISTING

<110>  Santaris Pharma A/S
 
<120>  RNA ANTAGONISTS TARGETING HSP27

<130>  1063WO

<150>  EP08104612
<151>  2008-07-02

<150>  US61/077588
<151>  2008-07-02

<160>  145   

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  1
gagatgtagc catgct                                                       16


<210>  2
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  2
gagatgtagc catgc                                                        15


<210>  3
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  3
agatgtagcc atgct                                                        15


<210>  4
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  4
gagatgtagc catg                                                         14


<210>  5
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  5
agatgtagcc atgc                                                         14


<210>  6
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  6
gatgtagcca tgct                                                         14


<210>  7
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  7
gagatgtagc cat                                                          13


<210>  8
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  8
agatgtagcc atg                                                          13


<210>  9
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  9
gatgtagcca tgc                                                          13


<210>  10
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  10
atgtagccat gct                                                          13


<210>  11
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  11
gagatgtagc ca                                                           12


<210>  12
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  12
agatgtagcc at                                                           12


<210>  13
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  13
gatgtagcca tg                                                           12


<210>  14
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  14
atgtagccat gc                                                           12


<210>  15
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  15
tgtagccatg ct                                                           12


<210>  16
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  16
acggtcagtg tgccct                                                       16


<210>  17
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  17
acggtcagtg tgccc                                                        15


<210>  18
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  18
cggtcagtgt gccct                                                        15


<210>  19
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  19
acggtcagtg tgcc                                                         14


<210>  20
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  20
cggtcagtgt gccc                                                         14


<210>  21
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  21
ggtcagtgtg ccct                                                         14


<210>  22
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  22
gtcagtgtgc cct                                                          13


<210>  23
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  23
ggtcagtgtg ccc                                                          13


<210>  24
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  24
cggtcagtgt gcc                                                          13


<210>  25
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  25
acggtcagtg tgc                                                          13


<210>  26
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  26
acggtcagtg tg                                                           12


<210>  27
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  27
cggtcagtgt gc                                                           12


<210>  28
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  28
ggtcagtgtg cc                                                           12


<210>  29
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  29
gtcagtgtgc cc                                                           12


<210>  30
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  30
tcagtgtgcc ct                                                           12


<210>  31
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  31
cgtgtatttc cgcgtg                                                       16


<210>  32
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  32
cgtgtatttc cgcgt                                                        15


<210>  33
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  33
gtgtatttcc gcgtg                                                        15


<210>  34
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  34
cgtgtatttc cgcg                                                         14


<210>  35
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  35
gtgtatttcc gcgt                                                         14


<210>  36
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  36
tgtatttccg cgtg                                                         14


<210>  37
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  37
cgtgtatttc cgc                                                          13


<210>  38
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  38
gtgtatttcc gcg                                                          13


<210>  39
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  39
tgtatttccg cgt                                                          13


<210>  40
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  40
gtatttccgc gtg                                                          13


<210>  41
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  41
cgtgtatttc cg                                                           12


<210>  42
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  42
gtgtatttcc gc                                                           12


<210>  43
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  43
tgtatttccg cg                                                           12


<210>  44
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  44
gtatttccgc gt                                                           12


<210>  45
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  45
tatttccgcg tg                                                           12


<210>  46
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  46
tgcgtggcta gcttgg                                                       16


<210>  47
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  47
tgcgtggcta gcttg                                                        15


<210>  48
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  48
gcgtggctag cttgg                                                        15


<210>  49
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  49
tgcgtggcta gctt                                                         14


<210>  50
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  50
gcgtggctag cttg                                                         14


<210>  51
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  51
cgtggctagc ttgg                                                         14


<210>  52
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  52
tgcgtggcta gct                                                          13


<210>  53
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  53
gcgtggctag ctt                                                          13


<210>  54
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  54
cgtggctagc ttg                                                          13


<210>  55
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  55
gtggctagct tgg                                                          13


<210>  56
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  56
tgcgtggcta gc                                                           12


<210>  57
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  57
gcgtggctag ct                                                           12


<210>  58
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  58
cgtggctagc tt                                                           12


<210>  59
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  59
gtggctagct tg                                                           12


<210>  60
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  60
tggctagctt gg                                                           12


<210>  61
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  61
atggtgatct cgttgg                                                       16


<210>  62
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  62
atggtgatct cgttg                                                        15


<210>  63
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  63
tggtgatctc gttgg                                                        15


<210>  64
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  64
atggtgatct cgtt                                                         14


<210>  65
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  65
tggtgatctc gttg                                                         14


<210>  66
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  66
ggtgatctcg ttgg                                                         14


<210>  67
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  67
atggtgatct cgt                                                          13


<210>  68
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  68
tggtgatctc gtt                                                          13


<210>  69
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  69
ggtgatctcg ttg                                                          13


<210>  70
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  70
gtgatctcgt tgg                                                          13


<210>  71
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  71
atggtgatct cg                                                           12


<210>  72
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  72
tggtgatctc gt                                                           12


<210>  73
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  73
ggtgatctcg tt                                                           12


<210>  74
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  74
gtgatctcgt tg                                                           12


<210>  75
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  75
tgatctcgtt gg                                                           12


<210>  76
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  76
attttgcagc ttctgg                                                       16


<210>  77
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  77
attttgcagc ttctg                                                        15


<210>  78
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  78
ttttgcagct tctgg                                                        15


<210>  79
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  79
attttgcagc ttct                                                         14


<210>  80
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  80
ttttgcagct tctg                                                         14


<210>  81
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  81
tttgcagctt ctgg                                                         14


<210>  82
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  82
attttgcagc ttc                                                          13


<210>  83
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  83
ttttgcagct tct                                                          13


<210>  84
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  84
tttgcagctt ctg                                                          13


<210>  85
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  85
ttgcagcttc tgg                                                          13


<210>  86
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  86
attttgcagc tt                                                           12


<210>  87
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  87
ttttgcagct tc                                                           12


<210>  88
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  88
tttgcagctt ct                                                           12


<210>  89
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  89
ttgcagcttc tg                                                           12


<210>  90
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  90
tgcagcttct gg                                                           12


<210>  91
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  91
ggcacagcca gtggcg                                                       16


<210>  92
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  92
ggcacagcca gtggc                                                        15


<210>  93
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  93
gcacagccag tggcg                                                        15


<210>  94
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  94
ggcacagcca gtgg                                                         14


<210>  95
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  95
gcacagccag tggc                                                         14


<210>  96
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  96
cacagccagt ggcg                                                         14


<210>  97
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  97
ggcacagcca gtg                                                          13


<210>  98
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  98
gcacagccag tgg                                                          13


<210>  99
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  99
cacagccagt ggc                                                          13


<210>  100
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  100
acagccagtg gcg                                                          13


<210>  101
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  101
ggcacagcca gt                                                           12


<210>  102
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  102
gcacagccag tg                                                           12


<210>  103
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  103
cacagccagt gg                                                           12


<210>  104
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  104
acagccagtg gc                                                           12


<210>  105
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  105
cagccagtgg cg                                                           12


<210>  106
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  106
tatcaaaaga acacac                                                       16


<210>  107
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  107
tatcaaaaga acaca                                                        15


<210>  108
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  108
atcaaaagaa cacac                                                        15


<210>  109
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  109
tatcaaaaga acac                                                         14


<210>  110
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  110
atcaaaagaa caca                                                         14


<210>  111
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  111
tcaaaagaac acac                                                         14


<210>  112
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  112
tatcaaaaga aca                                                          13


<210>  113
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  113
atcaaaagaa cac                                                          13


<210>  114
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  114
tcaaaagaac aca                                                          13


<210>  115
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  115
caaaagaaca cac                                                          13


<210>  116
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  116
tatcaaaaga ac                                                           12


<210>  117
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  117
atcaaaagaa ca                                                           12


<210>  118
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  118
tcaaaagaac ac                                                           12


<210>  119
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  119
caaaagaaca ca                                                           12


<210>  120
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  120
aaaagaacac ac                                                           12


<210>  121
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  121
ccgggagatg tagccatgct cgtc                                              24


<210>  122
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  122
ctccacggtg cagtgtgccc tcagg                                             25


<210>  123
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  123
gcagcgtgta tttccgcgtg aagc                                              24


<210>  124
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  124
ggactgcgtg gctagcttgg gcat                                              24


<210>  125
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  125
tgggatggtg atctcgttgg actg                                              24


<210>  126
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  126
tcggattttg cagcttctgg gccc                                              24


<210>  127
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  127
gggaggcaca gccagtggcg gcag                                              24


<210>  128
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)

<400>  128
aatgtatcaa aagaacacac aggt                                              24


<210>  129
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<400>  129
gagatgtagc catgct                                                       16


<210>  130
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<400>  130
acggtcagtg tgccct                                                       16


<210>  131
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<400>  131
cgtgtatttc cgcgtg                                                       16


<210>  132
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<400>  132
tgcgtggcta gcttgg                                                       16


<210>  133
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<400>  133
atggtgatct cgttgg                                                       16


<210>  134
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<400>  134
attttgcagc ttctgg                                                       16


<210>  135
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<400>  135
ggcacagcca gtggcg                                                       16


<210>  136
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Nucleotide analogue, such as LNA, such as beta-D-oxy LNA

<400>  136
tatcaaaaga acacac                                                       16


<210>  137
<211>  865
<212>  DNA
<213>  homo sapiens

<400>  137
ctcaaacacc gcctgctaaa aatacccgac tggaggagca taaaagcgca gccgagccca       60

gcgccccgca cttttctgag cagacgtcca gagcagagtc agccagcatg accgagcgcc      120

gcgtcccctt ctcgctcctg cggggcccca gctgggaccc cttccgcgac tggtacccgc      180

atagccgcct cttcgaccag gccttcgggc tgccccggct gccggaggag tggtcgcagt      240

ggttaggcgg cagcagctgg ccaggctacg tgcgccccct gccccccgcc gccatcgaga      300

gccccgcagt ggccgcgccc gcctacagcc gcgcgctcag ccggcaactc agcagcgggg      360

tctcggagat ccggcacact gcggaccgct ggcgcgtgtc cctggatgtc aaccacttcg      420

ccccggacga gctgacggtc aagaccaagg atggcgtggt ggagatcacc ggcaagcacg      480

aggagcggca ggacgagcat ggctacatct cccggtgctt cacgcggaaa tacacgctgc      540

cccccggtgt ggaccccacc caagtttcct cctccctgtc ccctgagggc acactgaccg      600

tggaggcccc catgcccaag ctagccacgc agtccaacga gatcaccatc ccagtcacct      660

tcgagtcgcg ggcccagctt gggggcccag aagctgcaaa atccgatgag actgccgcca      720

agtaaagcct tagcctggat gcccacccct gctgccgcca ctggctgtgc ctcccccgcc      780

acctgtgtgt tcttttgata catttatctt ctgtttttct caaataaagt tcaaagcaac      840

cacctgtaaa aaaaaaaaaa aaaaa                                            865


<210>  138
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<400>  138
gagatgtagc catgct                                                       16


<210>  139
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<400>  139
acggtcagtg tgccct                                                       16


<210>  140
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<400>  140
cgtgtatttc cgcgtg                                                       16


<210>  141
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<400>  141
tgcgtggcta gcttgg                                                       16


<210>  142
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<400>  142
atggtgatct cgttgg                                                       16


<210>  143
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<400>  143
attttgcagc ttctgg                                                       16


<210>  144
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<400>  144
ggcacagcca gtggcg                                                       16


<210>  145
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Beta-D-oxy LNA, all LNA cytosines 5methyl cytosine

<400>  145
tatcaaaaga acacac                                                       16


