                         SEQUENCE LISTING

<110>  Chilkoti, Ashutosh
 
<120>  THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES

<130>  PHAS-010/01US

<150>  US 61/076,221
<151>  2008-06-27

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  1

Val Pro Gly Gly 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  2

Ile Pro Gly Gly 
1               


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  3

Val Pro Gly Xaa Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  4

Ala Val Gly Val Pro 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  5

Ile Pro Gly Xaa Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  6

Ile Pro Gly Val Gly 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  7

Leu Pro Gly Xaa Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  8

Leu Pro Gly Val Gly 
1               5   


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  9

Val Ala Pro Gly Val Gly 
1               5       


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  10

Gly Val Gly Val Pro Gly Val Gly 
1               5               


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  11

Val Pro Gly Phe Gly Val Gly Ala Gly 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  12

Val Pro Gly Val Gly Val Pro Gly Gly 
1               5                   


<210>  13
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  13

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  14
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  14

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Glu Trp Leu Lys Asn Gly Gly Pro Ser Ser 
            20                  25                  30          


Gly Ala Pro Pro Pro Ser 
        35              


<210>  15
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Ile Val Glu Gln Cys Cys Ala Ser Val Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  16
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala 
            20                  25                  30  


<210>  17
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  17

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  18
<211>  44
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1 receptor agonist

<400>  18

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys 
        35                  40                  


<210>  19
<211>  31
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1 receptor agonist

<400>  19

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Ile Lys Gly Arg Gly 
            20                  25                  30      


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  20

Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  21

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-cleavable spacer sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Gly residue is optional

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Ser residue is optional

<400>  22

Gly Gly Gly Gly Ser Ser Ser Ser 
1               5               


<210>  23
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exendin-4/ELP sequence

<400>  23
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa       60

ttttgtttaa ctttaagaag gagatataca tatgcatggc gaaggcacct ttaccagcga      120

tctgagcaaa cagatggaag aagaagcggt gcgcctgttt attgaatggc tgaaaaacgg      180

cggcccgagc agcggcgcgc cgccgccgag cctcgagggc atgggtgggc cgggcgtggg      240

tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg      300


<210>  24
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4/ELP sequence

<400>  24

Met His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu 
1               5                   10                  15      


Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Leu Glu Gly Met Gly Gly Pro Gly 
        35                  40                  45              


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
    50                  55                  60                  


Gly Val Pro Gly Val 
65                  


<210>  25
<211>  140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exendin-4/ELP sequence with N-terminal Tev cleavage site

<400>  25
tatggaaaac ctgtatttcc aacatggcga aggcaccttt accagcgatc tgagcaaaca       60

gatggaagaa gaagcggtgc gcctgtttat tgaatggctg aaaaacggcg gcccgagcag      120

cggcgcgccg ccgccgagcc                                                  140


<210>  26
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4/ELP sequence with N-terminal Tev cleavage site

<400>  26

Met Glu Asn Leu Tyr Phe Gln His Gly Glu Gly Thr Phe Thr Ser Asp 
1               5                   10                  15      


Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp 
            20                  25                  30          


Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40                  45      


<210>  27
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exendin-4/ELP sequence with N-terminal Tev cleavage site and 
       additional N-terminal sequence

<400>  27
tatggatatc ccaacgaccg aaaacctgta tttccaacat ggcgaaggca cctttaccag       60

cgatctgagc aaacagatgg aagaagaagc ggtgcgcctg tttattgaat ggctgaaaaa      120

cggcggcccg agcagcggcg cgccgccgcc gagcc                                 155


<210>  28
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4/ELP sequence with N-terminal Tev cleavage site and 
       additional N-terminal sequence

<400>  28

Met Asp Ile Pro Thr Thr Glu Asn Leu Tyr Phe Gln His Gly Glu Gly 
1               5                   10                  15      


Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg 
            20                  25                  30          


Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro 
        35                  40                  45              


Pro Pro Ser 
    50      


<210>  29
<211>  176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exendin-4/ELP sequence with DsbA leader sequence

<400>  29
tatgaaaaag atttggctgg cgctggctgg tttagtttta gcgtttagcg catcggcgca       60

tggcgaaggc acctttacca gcgatctgag caaacagatg gaagaagaag cggtgcgcct      120

gtttattgaa tggctgaaaa acggcggccc gagcagcggc gcgccgccgc cgagcc          176


<210>  30
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4/ELP sequence with DsbA leader sequence

<400>  30

Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln 
            20                  25                  30          


Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
        35                  40                  45              


Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
    50                  55              


<210>  31
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insulin/ELP sequence

<400>  31
ctagaaataa ttttgtttaa ctttaagaag gagatataca tatgtttgtg aaccaacacc       60

tgtgcggctc acacctggtg gaagctctct acctagtgtg cggggaacga ggcttcttct      120

acacacccaa gacccgccgg gaggcagagg acctgcaggt ggggcaggtg gagctgggcg      180

ggggccctgg tgcaggcagc ctgcagccct tggccctgga ggggtccctg cagaagcgtg      240

gcattgtgga acaatgctgt accagcatct gctccctcta ccagctggag aactactgca      300

acctcgaggg catgggtggg ccgggcgtgg gtgttccggg cgtgggtgtt ccgggtggcg      360

gtgtgccggg cgcaggtgtt cctggtgtag gtgtgccggg                            400


<210>  32
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin/ELP sequence

<400>  32

Met Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu 
1               5                   10                  15      


Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg 
            20                  25                  30          


Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly 
        35                  40                  45              


Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
    50                  55                  60                  


Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Cys Asn Leu Glu Gly Met Gly Gly Pro Gly Val 
                85                  90                  95      


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            100                 105                 110         


Val Pro Gly Val Gly Val Pro 
        115                 


<210>  33
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro 
                405     


<210>  34
<211>  1218
<212>  DNA
<213>  Homo sapiens

<400>  34
gccaacgcgt tcctggagga gctgcggccg ggctccctgg agagggagtg caaggaggag       60

cagtgctcct tcgaggaggc ccgggagatc ttcaaggacg cggagaggac gaagctgttc      120

tggatttctt acagtgatgg ggaccagtgt gcctcaagtc catgccagaa tgggggctcc      180

tgcaaggacc agctccagtc ctatatctgc ttctgcctcc ctgccttcga gggccggaac      240

tgtgagacgc acaaggatga ccagctgatc tgtgtgaacg agaacggcgg ctgtgagcag      300

tactgcagtg accacacggg caccaagcgc tcctgtcggt gccacgaggg gtactctctg      360

ctggcagacg gggtgtcctg cacacccaca gttgaatatc catgtggaaa aatacctatt      420

ctagaaaaaa gaaatgccag caaaccccaa ggccgaattg tggggggcaa ggtgtgcccc      480

aaaggggagt gtccatggca ggtcctgttg ttggtgaatg gagctcagtt gtgtgggggg      540

accctgatca acaccatctg ggtggtctcc gcggcccact gtttcgacaa aatcaagaac      600

tggaggaacc tgatcgcggt gctgggcgag cacgacctca gcgagcacga cggggatgag      660

cagagccggc gggtggcgca ggtcatcatc cccagcacgt acgtcccggg caccaccaac      720

cacgacatcg cgctgctccg cctgcaccag cccgtggtcc tcactgacca tgtggtgccc      780

ctctgcctgc ccgaacggac gttctctgag aggacgctgg ccttcgtgcg cttctcattg      840

gtcagcggct ggggccagct gctggaccgt ggcgccacgg ccctggagct catggtgctc      900

aacgtgcccc ggctgatgac ccaggactgc ctgcagcagt cacggaaggt gggagactcc      960

ccaaatatca cggagtacat gttctgtgcc ggctactcgg atggcagcaa ggactcctgc     1020

aagggggaca gtggaggccc acatgccacc cactaccggg gcacgtggta cctgacgggc     1080

atcgtcagct ggggccaggg ctgcgcaacc gtgggccact ttggggtgta caccagggtc     1140

tcccagtaca tcgagtggct gcaaaagctc atgcgctcag agccacgccc aggagtcctc     1200

ctgcgagccc catttccc                                                   1218


<210>  35
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  35
tatgcatggc gaaggcacct ttaccagcga tct                                    33


<210>  36
<211>  62
<212>  DNA
<213>  Homo sapiens

<400>  36
gagcaaacag atggaagaag aagcggtgcg cctgtttatt gaatggctga aaaacggcgg       60

cc                                                                      62


<210>  37
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  37
cgagcagcgg cgcgccgccg ccgagcc                                           27


<210>  38
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  38
tcgaggctcg gcggcggcgc gccgctgctc gggcc                                  35


<210>  39
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  39
gccgtttttc agccattcaa taaacaggcg caccgcttct tcttccatct gtttgctcag       60

atc                                                                     63


<210>  40
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  40
gctggtaaag gtgccttcgc catgca                                            26


<210>  41
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for Exendin-4/ELP sequence with N-terminal Tev cleavage 
       site

<400>  41
tatggaaaac ctgtatttcc aacatggcga aggcaccttt accagcgatc t                51


<210>  42
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for Exendin-4/ELP sequence with N-terminal Tev cleavage 
       site

<400>  42
gctggtaaag gtgccttcgc catgttggaa atacaggttt tcca                        44


<210>  43
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for Exendin-4/ELP sequence with N-terminal Tev cleavage 
       site and additional N-terminal sequence

<400>  43
tatggatatc ccaacgaccg aaaacctgta tttccaacat ggcgaaggca cctttaccag       60

cgatct                                                                  66


<210>  44
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for

<400>  44
gctggtaaag gtgccttcgc catgttggaa atacaggttt tcggtcgttg ggatatcca        59


<210>  45
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for Exendin-4/ELP sequence with DsbA leader sequence

<400>  45
tatgaaaaag atttggctgg cgctggctgg tttagtttta gcgtttagcg catcggcgca       60

tggcgaaggc acctttacca gcgatct                                           87


<210>  46
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for Exendin-4/ELP sequence with DsbA leader sequence

<400>  46
gctggtaaag gtgccttcgc catgcgccga tgcgctaaac gctaaaacta aaccagccag       60

cgccagccaa atctttttca                                                   80


<210>  47
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for Insulin/ELP sequence

<400>  47
gaaggagata tacatatgtt tgtgaaccaa cacctgtgc                              39


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for Insulin/ELP sequence

<400>  48
cccatgccct cgaggttgca gtagttctcc                                        30


<210>  49
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  49
ctagctagca tggtctccca ggccctc                                           27


<210>  50
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  50
tattcttgcg gccgcgggaa atggggctcg cag                                    33


<210>  51
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  51
atgtttgtga accaacacct gtgcggctca cacctggtgg aagctctcta cctagtgtgc       60

ggggaacgag gcttcttcta cacacccaag acccgccggg aggcagagga cctgcaggtg      120

gggcaggtgg agctgggcgg gggccctggt gcaggcagcc tgcagccctt ggccctggag      180

gggtccctgc agaagcgtgg cattgtggaa caatgctgta ccagcatctg ctccctctac      240

cagctggaga actactgcaa c                                                261


<210>  52
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu 
1               5                   10                  15      


Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg 
            20                  25                  30          


Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly 
        35                  40                  45              


Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
    50                  55                  60                  


Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Cys Asn 
                85          


<210>  53
<211>  1700
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPB0868 DNA sequence

<400>  53
taatacgact cactataggg gaattgtgag cggataacaa ttcccctcta gaaataattt       60

tgtttaactt taagaaggag atatacatat ggagaacctg tatttccaac atggcgaagg      120

tacctttaca agcgatgtta gttcatatct ggagggccag gcggcaaagg aattcattgc      180

gtggctggtg aaaggccgcg gcctcgaggg catgggtggg ccgggcgtgg gtgttccggg      240

cgtgggtgtt ccgggtggcg gtgtgccggg cgcaggtgtt cctggtgtag gtgtgccggg      300

tgttggtgtg ccgggtgttg gtgtaccagg tggcggtgtt ccgggtgcag gcgttccggg      360

tggcggtgtg ccgggcgtgg gtgttccggg cgtgggtgtt ccgggtggcg gtgtgccggg      420

cgcaggtgtt cctggtgtag gtgtgccggg tgttggtgtg ccgggtgttg gtgtaccagg      480

tggcggtgtt ccgggtgcag gcgttccggg tggcggtgtg ccgggcgtgg gtgttccggg      540

cgtgggtgtt ccgggtggcg gtgtgccggg cgcaggtgtt cctggtgtag gtgtgccggg      600

tgttggtgtg ccgggtgttg gtgtaccagg tggcggtgtt ccgggtgcag gcgttccggg      660

tggcggtgtg ccgggcgtgg gtgttccggg cgtgggtgtt ccgggtggcg gtgtgccggg      720

cgcaggtgtt cctggtgtag gtgtgccggg tgttggtgtg ccgggtgttg gtgtaccagg      780

tggcggtgtt ccgggtgcag gcgttccggg tggcggtgtg ccgggcgtgg gtgttccggg      840

cgtgggtgtt ccgggtggcg gtgtgccggg cgcaggtgtt cctggtgtag gtgtgccggg      900

tgttggtgtg ccgggtgttg gtgtaccagg tggcggtgtt ccgggtgcag gcgttccggg      960

tggcggtgtg ccgggcgtgg gtgttccggg cgtgggtgtt ccgggtggcg gtgtgccggg     1020

cgcaggtgtt cctggtgtag gtgtgccggg tgttggtgtg ccgggtgttg gtgtaccagg     1080

tggcggtgtt ccgggtgcag gcgttccggg tggcggtgtg ccgggcgtgg gtgttccggg     1140

cgtgggtgtt ccgggtggcg gtgtgccggg cgcaggtgtt cctggtgtag gtgtgccggg     1200

tgttggtgtg ccgggtgttg gtgtaccagg tggcggtgtt ccgggtgcag gcgttccggg     1260

tggcggtgtg ccgggcgtgg gtgttccggg cgtgggtgtt ccgggtggcg gtgtgccggg     1320

cgcaggtgtt cctggtgtag gtgtgccggg tgttggtgtg ccgggtgttg gtgtaccagg     1380

tggcggtgtt ccgggtgcag gcgttccggg tggcggtgtg ccgggcgtgg gtgttccggg     1440

cgtgggtgtt ccgggtggcg gtgtgccggg cgcaggtgtt cctggtgtag gtgtgccggg     1500

tgttggtgtg ccgggtgttg gtgtaccagg tggcggtgtt ccgggtgcag gcgttccggg     1560

tggcggtgtg ccgggctggc cgtgataagc tagcatgact ggtggacagc aaatgggtcg     1620

gatccgaatt cgagctccgt cgagcaccac caccaccacc actgagatcc ggctgctaac     1680

aaagcccgaa aggaagctga                                                 1700


<210>  54
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(A8G,7-37)ELP1-90 amino acid sequence

<400>  54

Met Glu Asn Leu Tyr Phe Gln His Gly Glu Gly Thr Phe Thr Ser Asp 
1               5                   10                  15      


Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp 
            20                  25                  30          


Leu Val Lys Gly Arg Gly Leu Glu Gly Met Gly Gly Pro Gly Val Gly 
        35                  40                  45              


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    50                  55                  60                  


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
65                  70                  75                  80  


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                85                  90                  95      


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            100                 105                 110         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        115                 120                 125             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    130                 135                 140                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
145                 150                 155                 160 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                165                 170                 175     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            180                 185                 190         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        195                 200                 205             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    210                 215                 220                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
225                 230                 235                 240 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                245                 250                 255     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            260                 265                 270         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        275                 280                 285             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    290                 295                 300                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
305                 310                 315                 320 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                325                 330                 335     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            340                 345                 350         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        355                 360                 365             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    370                 375                 380                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
385                 390                 395                 400 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                405                 410                 415     


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            420                 425                 430         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        435                 440                 445             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    450                 455                 460                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
465                 470                 475                 480 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                485                 490                 495     


Trp Pro 
        


<210>  55
<211>  2050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPB1022 DNA sequence

<400>  55
taatacgact cactataggg gaattgtgag cggataacaa ttcccctcta gaaataattt       60

tgtttaactt taagaaggag atatacatat ggagaacctg tatttccaac atggcgaagg      120

tacctttaca agcgatgtta gttcatatct ggagggccag gcggcaaagg aatttattgc      180

gtggctggtg aaaggccgcg gcgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg      240

tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg      300

tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg      360

cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg      420

tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg      480

tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg      540

tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg      600

tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg      660

cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg      720

tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg      780

tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg      840

tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg      900

tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg      960

cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg     1020

tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg     1080

tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg     1140

tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg     1200

tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg     1260

cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg     1320

tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg     1380

tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg     1440

tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg     1500

tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg     1560

cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg     1620

tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg     1680

tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg     1740

tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg     1800

tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg     1860

cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg     1920

tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg     1980

tgcaggcgtt ccgggtggcg gtgtgccggg ctggccgtga taagctagca tgactggtgg     2040

acagcaaatg                                                            2050


<210>  56
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(A8G,7-37)ELP1-120 amino acid sequence

<400>  56

Met Glu Asn Leu Tyr Phe Gln His Gly Glu Gly Thr Phe Thr Ser Asp 
1               5                   10                  15      


Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp 
            20                  25                  30          


Leu Val Lys Gly Arg Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        35                  40                  45              


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
    50                  55                  60                  


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
65                  70                  75                  80  


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
                85                  90                  95      


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
            100                 105                 110         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        115                 120                 125             


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
    130                 135                 140                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
145                 150                 155                 160 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                165                 170                 175     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
            180                 185                 190         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        195                 200                 205             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    210                 215                 220                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
225                 230                 235                 240 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                245                 250                 255     


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
            260                 265                 270         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
        275                 280                 285             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    290                 295                 300                 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
305                 310                 315                 320 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                325                 330                 335     


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            340                 345                 350         


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        355                 360                 365             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    370                 375                 380                 


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
385                 390                 395                 400 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
                405                 410                 415     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            420                 425                 430         


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        435                 440                 445             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
    450                 455                 460                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
465                 470                 475                 480 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
                485                 490                 495     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
            500                 505                 510         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        515                 520                 525             


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
    530                 535                 540                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
545                 550                 555                 560 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                565                 570                 575     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
            580                 585                 590         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        595                 600                 605             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    610                 615                 620                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
625                 630                 635                 640 


Gly Trp Pro 
            


<210>  57
<211>  3700
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPB0788 DNA sequence

<400>  57
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct      960

gcagtcttcg taacccagga ggaagcccac ggcgtcctgc accggcgccg gcgcgccaac     1020

gcgttcctgg aggagctacg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc     1080

tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt     1140

tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag     1200

gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag     1260

acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc     1320

agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca     1380

gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa     1440

aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg     1500

gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg ggggaccctg     1560

atcaacacca tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg     1620

aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc     1680

cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac caaccacgac     1740

atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc     1800

ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc     1860

ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt cctcaacgtg     1920

ccccggctga tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat     1980

atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg     2040

gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac gggcatcgtc     2100

agctggggcc agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag     2160

tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga     2220

gccccatttc ccgcggccgc tgaaaacctg tattttcagg gtggggccgc tgggccgggc     2280

gtgggagttc ccggcgtggg agttcccgga ggcggagtgc ccggcgcagg agttcctgga     2340

gtcggagtgc ccggagttgg agtgcccgga gttggagtcc caggaggcgg agtccccgga     2400

gcaggcgtcc ccggaggcgg agtgccgggc gtgggagttc ccggcgtggg agttcccgga     2460

ggcggagtgc ccggcgcagg agttcctgga gtcggagtgc ccggagttgg agtgcccgga     2520

gttggagtcc caggaggcgg agtccccgga gcaggcgtcc ccggaggcgg agtgccgggc     2580

gtgggagttc ccggcgtggg agttcccgga ggcggagtgc ccggcgcagg agttcctgga     2640

gtcggagtgc ccggagttgg agtgcccgga gttggagtcc caggaggcgg agtccccgga     2700

gcaggcgtcc ccggaggcgg agtgccgggc gtgggagttc ccggcgtggg agttcccgga     2760

ggcggagtgc ccggcgcagg agttcctgga gtcggagtgc ccggagttgg agtgcccgga     2820

gttggagtcc caggaggcgg agtccccgga gcaggcgtcc ccggaggcgg agtgccgggc     2880

gtgggagttc ccggcgtggg agttcccgga ggcggagtgc ccggcgcagg agttcctgga     2940

gtcggagtgc ccggagttgg agtgcccgga gttggagtcc caggaggcgg agtccccgga     3000

gcaggcgtcc ccggaggcgg agtgccgggc gtgggagttc ccggcgtggg agttcccgga     3060

ggcggagtgc ccggcgcagg agttcctgga gtcggagtgc ccggagttgg agtgcccgga     3120

gttggagtcc caggaggcgg agtccccgga gcaggcgtcc ccggaggcgg agtgccgggc     3180

gtgggagttc ccggcgtggg agttcccgga ggcggagtgc ccggcgcagg agttcctgga     3240

gtcggagtgc ccggagttgg agtgcccgga gttggagtcc caggaggcgg agtccccgga     3300

gcaggcgtcc ccggaggcgg agtgccgggc gtgggagttc ccggcgtggg agttcccgga     3360

ggcggagtgc ccggcgcagg agttcctgga gtcggagtgc ccggagttgg agtgcccgga     3420

gttggagtcc caggaggcgg agtccccgga gcaggcgtcc ccggaggcgg agtgccgggc     3480

gtgggagttc ccggcgtggg agttcccgga ggcggagtgc ccggcgcagg agttcctgga     3540

gtcggagtgc ccggagttgg agtgcccgga gttggagtcc caggaggcgg agtccccgga     3600

gcaggcgtcc ccggaggcgg agtgccgggc tggccttgat gactcgagtc tagagggccc     3660

gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt                           3700


<210>  58
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor VII-ELP 1-90 amino acid sequence

<400>  58

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Ala Ala Ala Glu 
        435                 440                 445             


Asn Leu Tyr Phe Gln Gly Gly Ala Ala Gly Pro Gly Val Gly Val Pro 
    450                 455                 460                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
465                 470                 475                 480 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                485                 490                 495     


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
            500                 505                 510         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        515                 520                 525             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    530                 535                 540                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
545                 550                 555                 560 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                565                 570                 575     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            580                 585                 590         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
        595                 600                 605             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    610                 615                 620                 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
625                 630                 635                 640 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
                645                 650                 655     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            660                 665                 670         


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        675                 680                 685             


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    690                 695                 700                 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
705                 710                 715                 720 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
                725                 730                 735     


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            740                 745                 750         


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        755                 760                 765             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
    770                 775                 780                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
785                 790                 795                 800 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
                805                 810                 815     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
            820                 825                 830         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        835                 840                 845             


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
    850                 855                 860                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
865                 870                 875                 880 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                885                 890                 895     


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro 
            900                 905                 910         


<210>  59
<211>  31
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1 receptor agonist

<400>  59

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


