                         SEQUENCE LISTING

<110>  Maihle, Nita
 
<120>  Soluble ErbB3 Detection, Regulation, and Treatment of Cancer

<130>  

<140>  Not yet assigned
<141>  2008-06-23

<150>  
<151>  

<160>  8     

<170>  PatentIn version 3.4

<210>  1
<211>  1800
<212>  DNA
<213>  Homo sapiens

<400>  1
cgggcccccc ctcgaggtcg ggccggactt ggctgggctc ccttcaccct ctgcggagtc     60

atgagggcga acgacgctct gcaggtgctg ggcttgcttt tcagcctggc ccggggctcc    120

gaggtgggca actctcaggc agtgtgtcct gggactctga atggcctgag tgtgaccggc    180

gatgctgaga accaatacca gacactgtac aagctctacg agaggtgtga ggtggtgatg    240

gggaaccttg agattgtgct cacgggacac aatgccgacc tctccttcct gcagtggatt    300

cgagaagtga caggctatgt cctcgtggcc atgaatgaat tctctactct accattgccc    360

aacctccgcg tggtgcgagg gacccaggtc tacgatggga agtttgccat cttcgtcatg    420

ttgaactata acaccaactc cagccacgct ctgcgccagc tccgcttgac tcagctcacc    480

gagattctgt cagggggtgt ttatattgag aagaacgata agctttgtca catggacaca    540

attgactgga gggacatcgt gagggaccga gatgctgaga tagtggtgaa ggacaatggc    600

agaagctgtc ccccctgtca tgaggtttgc aaggggcgat gctggggtcc tggatcagaa    660

gactgccaga cattgaccaa gaccatctgt gctcctcagt gtaatggtca ctgctttggg    720

cccaacccca accagtgctg ccatgatgag tgtgccgggg gctgctcagg ccctcaggac    780

acagactgct ttgcctgccg gcacttcaat gacagtggag cctgtgtacc tcgctgtcca    840

cagcctcttg tctacaacaa gctaactttc cagctggaac ccaatcccca caccaagtat    900

cagtatggag gagtttgtgt agccagctgt ccccataact ttgtggtgga tcaaacatcc    960

tgtgtcaggg cctgtcctcc tgacaagatg gaagtagata aaaatgggct caagatgtgt   1020

gagccttgtg ggggactatg tcccaaagcc tgtgagggaa caggctctgg gagccgcttc   1080

cagactgtgg actcgagcaa cattgatgga tttgtgaact gcaccaagat cctgggcaac   1140

ctggactttc tgatcaccgg cctcaatgga gacccctggc acaagatccc tgccctggac   1200

ccagagaagc tcaatgtctt ccggacagta cgggagatca caggttacct gaacatccag   1260

tcctggccgc cccacatgca caacttcagt gttttttcca atttgacaac cattggaggc   1320

agaagcctct acaaccgggg cttctcattg ttgatcatga agaacttgaa tgtcacatct   1380

ctgggcttcc gatccctgaa ggaaattagt gctgggcgta tctatataag tgccaatagg   1440

cagctctgct accaccactc tttgaactgg accaaggtgc ttcgggggcc tacggaagag   1500

cgactagaca tcaagcataa tcggccgcgc agagactgcg tggcagaggg caaagtgtgt   1560

gacccactgt gctcctctgg gggatgctgg ggcccaggcc ctggtcagtg cttgtcctgt   1620

cgaaattata gccgaggagg tgtctgtgtg acccactgca actttctgaa tgggtacagt   1680

aaggggagcc agtcaaggat gggtgggggt ggggccctgc aatggaactg ttcaggtggc   1740

atacaataaa agtctttaga cagctttcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1800


<210>  2
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Tyr Ser Lys Gly Ser Gln 
    530                 535                 540                 


Ser Arg Met Gly Gly Gly Gly Ala Leu Gln Trp Asn Cys Ser Gly Gly 
545                 550                 555                 560 


Ile Gln 
        


<210>  3
<211>  1420
<212>  DNA
<213>  Homo sapiens

<400>  3
cgggcccccc ctcgaggtcg ggccggactt ggctgggctc ccttcaccct ctgcggagtc     60

atgagggcga acgacgctct gcaggtgctg ggcttgcttt tcagcctggc ccggggctcc    120

gaggtgggca actctcaggc agtgtgtcct gggactctga atggcctgag tgtgaccggc    180

gatgctgaga accaatacca gacactgtac aagctctacg agaggtgtga ggtggtgatg    240

gggaaccttg agattgtgct cacgggacac aatgccgacc tctccttcct gcagtggatt    300

cgagaagtga caggctatgt cctcgtggcc atgaatgaat tctctactct accattgccc    360

aacctccgcg tggtgcgagg gacccaggtc tacgatggga agtttgccat cttcgtcatg    420

ttgaactata acaccaactc cagccacgct ctgcgccagc tccgcttgac tcagctcacc    480

gagattctgt cagggggtgt ttatattgag aagaacgata agctttgtca catggacaca    540

attgactgga gggacatcgt gagggaccga gatgctgaga tagtggtgaa ggacaatggc    600

agaagctgtc ccccctgtca tgaggtttgc aaggggcgat gctggggtcc tggatcagaa    660

gactgccaga cattgaccaa gaccatctgt gctcctcagt gtaatggtca ctgctttggg    720

cccaacccca accagtgctg ccatgatgag tgtgccgggg gctgctcagg ccctcaggac    780

acagactgct ttgcctgccg gcacttcaat gacagtggag cctgtgtacc tcgctgtcca    840

cagcctcttg tctacaacaa gctaactttc cagctggaac ccaatcccca caccaagtat    900

cagtatggag gagtttgtgt agccagctgt ccccataact ttgtggtgga tcaaacatcc    960

tgtgtcaggg cctgtcctcc tgacaagatg gaagtagata aaaatgggct caagatgtgt   1020

gagccttgtg ggggactatg tcccaaaggt gggtaggaga tggtaagaag ttgtaaagag   1080

acagcctttc ctctgagcct gcgcagacca cccccactga acctctctta catttgcagc   1140

ctgtgaggga acaggctctg ggagccgctt ccagactgtg gactcgagca acattgatgg   1200

atttgtgaac tgcaccaaga tcctgggcaa cctggacttt ctgatcaccg gcctcaatgg   1260

gttagagatc ctgccttccc tccttagacc ccagcccacg cacccctcac agttcatttc   1320

attggccaaa actttcctat gtggagctga ctaggaatca aagtcataaa attctagcct   1380

gttacaaagg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         1420


<210>  4
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Gly Gly 
                325                 330     


<210>  5
<211>  2005
<212>  DNA
<213>  Homo sapiens

<400>  5
cgggcccccc ctcgaggtcg ggccggactt ggctgggctc ccttcaccct ctgcggagtc     60

atgagggcga acgacgctct gcaggtgctg ggcttgcttt tcagcctggc ccggggctcc    120

gaggtgggca actctcaggc agtgtgtcct gggactctga atggcctgag tgtgaccggc    180

gatgctgaga accaatacca gacactgtac aagctctacg agaggtgtga ggtggtgatg    240

gggaaccttg agattgtgct cacgggacac aatgccgacc tctccttcct gcagtggatt    300

cgagaagtga caggctatgt cctcgtggcc atgaatgaat tctctactct accattgccc    360

aacctccgcg tggtgcgagg gacccaggtc tacgatggga agtttgccat cttcgtcatg    420

ttgaactata acaccaactc cagccacgct ctgcgccagc tccgcttgac tcagctcacc    480

gagattctgt cagggggtgt ttatattgag aagaacgata agctttgtca catggacaca    540

attgactgga gggacatcgt gagggaccga gatgctgaga tagtggtgaa ggacaatggc    600

agaagctgtc ccccctgtca tgaggtttgc aaggggcgat gctggggtcc tggatcagaa    660

gactgccaga cattgaccaa gaccatctgt gctcctcagt gtaatggtca ctgctttggg    720

cccaacccca accagtgctg ccatgatgag tgtgccgggg gctgctcagg ccctcaggac    780

acagactgct ttgcctgccg gcacttcaat gacagtggag cctgtgtacc tcgctgtcca    840

cagcctcttg tctacaacaa gctaactttc cagctggaac ccaatcccca caccaagtat    900

cagtatggag gagtttgtgt agccagctgt ccccataact ttgtggtgga tcaaacatcc    960

tgtgtcaggg cctgtcctcc tgacaagatg gaagtagata aaaatgggct caagatgtgt   1020

gagccttgtg ggggactatg tcccaaagcc tgtgagggaa caggctctgg gagccgcttc   1080

cagactgtgg actcgagcaa cattgatgga tttgtgaact gcaccaagat cctgggcaac   1140

ctggactttc tgatcaccgg cctcaatgga gacccctggc acaagatccc tgccctggac   1200

ccagagaagc tcaatgtctt ccggacagta cgggagatca caggttacct gaacatccag   1260

tcctggccgc cccacatgca caacttcagt gttttttcca atttgacaac cattggaggc   1320

agaagcctct acaaccgggg cttctcattg ttgatcatga agaacttgaa tgtcacatct   1380

ctgggcttcc gatccctgaa ggaaattagt gctgggcgta tctatataag tgccaatagg   1440

cagctctgct accaccactc tttgaactgg accaaggtgc ttcgggggcc tacggaagag   1500

cgactagaca tcaagcataa tcggccgcgc agagactgcg gtgagggaaa gggtctgcta   1560

ggtggtgaga atagggagtc agggaggaga gggctgaaag gactattctg ccctagacgt   1620

gggagtaggg ttgagggatg gaaccaagga gaagggggct gttaggctgg aagcagtaac   1680

gaggaagaat aatgaagaga gggcttgctg ggagtcctca gactcctctc ctaacccacc   1740

ccttcctttc cagtggcaga gggcaaagtg tgtgacccac tgtgctcctc tgggggatgc   1800

tggggcccag gccctggtca gtgcttgtcc tgtcgaaatt atagccgagg aggtgtctgt   1860

gtgacccact gcaactttct gaatgggtac agtaagggga gccagtcaag gatgggtggg   1920

ggtggggccc tgcaatggaa ctgttcaggt ggcatacaat aaaagtcttt agacagcaaa   1980

aaaaaaaaaa aaaaaaaaaa aaaaa                                         2005


<210>  6
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Gly Glu Gly 
                485                 490                 495     


Lys Gly Leu Leu Gly Gly Glu Asn Arg Glu Ser Gly Arg Arg Gly Leu 
            500                 505                 510         


Lys Gly Leu Phe Cys Pro Arg Arg Gly Ser Arg Val Glu Gly Trp Asn 
        515                 520                 525             


Gln Gly Glu Gly Gly Cys 
    530                 


<210>  7
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  7
cgggcccccc ctcgaggtcg ggccggactt ggctgggctc ccttcaccct ctgcggagtc     60

atgagggcga acgacgctct gcaggtgctg ggcttgcttt tcagcctggc ccggggctcc    120

gaggtgggca actctcaggc agtgtgtcct gggactctga atggcctgag tgtgaccggc    180

gatgctgaga accaatacca gacactgtac aagctctacg agaggtgtga ggtggtgatg    240

gggaaccttg agattgtgct cacgggacac aatgccgacc tctccttcct gcagtggatt    300

cgagaagtga caggctatgt cctcgtggcc atgaatgaat tctctactct accattgccc    360

aacctccgcg tggtgcgagg gacccaggtc tacgatggga agtttgccat cttcgtcatg    420

ttgaactata acaccaactc cagccacgct ctgcgccagc tccgcttgac tcagctcacc    480

gagattctgt cagggggtgt ttatattgag aagaacgata agctttgtca catggacaca    540

attgactgga gggacatcgt gagggaccga gatgctgaga tagtggtgaa ggacaatggc    600

agaagctgtc ccccctgtca tgaggtttgc aaggggcgat gctggggtcc tggatcagaa    660

gactgccaga cattgaccaa gaccatctgt gctcctcagt gtaatggtca ctgctttggg    720

cccaacccca accagtgctg ccatgatgag tgtgccgggg gctgctcagg ccctcaggac    780

acagactgct ttgcctgccg gcacttcaat gacagtggag cctgtgtacc tcgctgtcca    840

cagcctcttg tctacaacaa gctaactttc cagctggaac ccaatcccca caccaagtat    900

cagtatggag gagtttgtgt agccagctgt ccccataact ttgtggtgga tcaaacatcc    960

tgtgtcaggg cctgtcctcc tgacaagatg gaagtagata aaaatgggct caagatgtgt   1020

gagccttgtg ggggactatg tcccaaagcc tgtgagggaa caggctctgg gagccgcttc   1080

cagactgtgg actcgagcaa cattgatgga tttgtgaact gcaccaagat cctgggcaac   1140

ctggactttc tgatcaccgg cctcaatggg ttagagatcc tgccttccct ccttagaccc   1200

cagcccacgc acccctcaca gttcatttca ttggccaaaa ctttcctatg tggagctgac   1260

taggaatcaa agtcataaaa ttctagcctg ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1320


<210>  8
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Leu Glu Ile Leu Pro Ser Leu Leu Arg Pro Gln Pro Thr His 
    370                 375                 380                 


Pro Ser Gln Phe Ile Ser Leu Ala Lys Thr Phe Leu Cys Gly Ala Asp 
385                 390                 395                 400 


