                         SEQUENCE LISTING

<110>  Dimarchi, et al.
 
<120>  GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS

<130>  29920-207042 (31135/43977C)

<160>  656   

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens
                                        
<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr         
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  7

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<400>  8

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  9

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  11

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at position 12 and 16

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (22)..(24)
<223>  Lactam ring between side chains at positions 22 and 24

<400>  14

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring formed between side chains at positions 24 and 28

<400>  15

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<400>  16

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<400>  17

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Asp Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  18

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Variable amino acid

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  20

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser, Ala, Gly, N-methyl Ser or aminoisobutyric acid

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  23

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  24

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids Exendin-4

<400>  26

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 8 
       amino acids of oxyntomodulin

<400>  27

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Lys Arg Asn Arg 
1               


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exendin-4


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  29

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  31
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  31

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  32

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  36

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cys

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through thiol group of Cys

<400>  38

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  39

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  40

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  41

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  42

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  43

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Thr 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Glu or Thr

<400>  44

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys or Glu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Gln, Glu, Lys, homoglutamic acid, cysteic acid or 
       homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Glu or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  45

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<400>  46

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  47

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  48

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  49

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  50
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  50

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn, or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Glu, homoglutamic acid, or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  51

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  52
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  52

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or an acidic amino acid

<400>  53

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  54
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg or Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Arg or Ala

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp or Glu

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Ala

<400>  54

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Xaa Ala Lys Xaa Phe Xaa Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  55
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His or
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, aminoisobutyric 
       acid (AIB) or N-methyl Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Tyr or Trp

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys, Citrulline, Orn or Arg

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg, Gln, Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Arg, Ala, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocystein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Arg, Citrulline, Orn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl phenyalanine

<400>  55

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  56
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Cys, Orn, homocycsteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl phenyalanine

<400>  56

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl- His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side changes at position 12 and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Cys, Orn, homocycsteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  57

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  58
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  58

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB, or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at position 20 and 24

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl pheylalanine

<400>  59

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Glu Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  60
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn, or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at position 24 and 28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  60

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Glu Trp Leu Xaa Lys Xaa 
            20                  25                  


<210>  61
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, Aib, N-methyl, Ala or 
       D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG or not present

<400>  61

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Xaa Ala Lys Asp Phe Val Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  62
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, AIB0, N-methyl Ala, or 
       D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG or not present

<400>  62

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Xaa Ala Lys Glu Phe Ile Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  63
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Lys, Cys, Orn, homocysteine or acetyl phealanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys, Cys, Orn, homocysteine or acetyl phealanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  63

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  64
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<400>  64

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Pro Pro Pro Ser 
        35              


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exdendin-4


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Cys-PEG

<400>  65

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10      


<210>  66
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  66

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  67

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  68

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  69
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  69

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  70

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  71
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  71

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  72
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  72

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  73
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  73

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  74
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  74

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  75
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  75

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  76
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  76

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  77
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  77

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  78
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  78

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  79
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  79

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  80
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  80

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  81
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  81

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  82
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  82

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  83

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  84

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  85

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  86
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  86

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  87

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  88

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  89
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  89

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  90

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  91
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  91

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  92
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  92

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  93
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  93

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  94

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  95
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  95

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  96
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  96

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  97
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  97

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  98
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  98

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  99
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  99

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  100

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  101
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  101

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  102
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  102

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  103
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  103

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  104
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  104

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  105

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  106
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  106

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  107
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  107

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  108
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisebutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  108

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  109
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  109

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  110

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  111

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  112
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  112

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  113
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  113

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  114
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  114

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  115
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  115

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  116

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  117
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  117

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  118
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  118

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  119
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  119

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  120
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  120

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  121
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  121

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  122
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  122

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  123
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  123

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  124
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  124

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  125
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  125

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  126
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  126

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  127
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  127

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  128
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  128

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  129
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  129

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  130
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  130

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  131
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  131

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  132
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  132

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  133
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  133

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  134
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  134

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  135
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  135

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  136
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  136

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  137
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  137

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  138
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  138

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  139
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  139

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  140
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  140

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  141
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  141

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  142
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  142

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  143
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  143

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  144
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  144

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  145
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  145

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  146
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  146

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  147
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  147

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  148
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  148

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  149
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  149

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  150
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  150

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  151
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  151

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  152
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  152

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  153
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  153

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  154
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  154

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  155
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  155

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  156
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  156

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  157
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  157

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  158
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  158

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  159
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  159

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  160
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  160

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  161
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  161

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  162
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  162

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  163
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  163

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  164
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  164

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  165
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  165

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  166
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  166

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  167
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  167

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  168
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  168

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  169
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  169

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  170
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  170

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  171
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  171

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  172
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  172

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  173
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  173

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  174
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  174

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  175
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  175

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  176
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  176

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  177
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  177

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  178
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  178

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  179
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  179

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  180
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  180

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  181
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  181

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  182
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  182

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  183
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  183

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  184
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  184

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  185
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  185

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  186
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  186

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  187
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  187

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  188
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  188

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  189
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  189

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  190
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  190

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  191
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  191

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  192
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  192

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  193
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  193

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  194
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  194

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  195
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  195

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  196
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  196

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  197
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  197

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  198
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  198

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  199
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  199

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  200
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  200

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  201
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  201

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  202
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  202

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  203
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  203

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  204
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  204

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  205
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  c-term amidation

<400>  205

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  206
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  206

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  207
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  207

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  208
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  208

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  209
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  209

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  210
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  210

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  211
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  211

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  212
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  212

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  213
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  213

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  214
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  214

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  215
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  215

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  216
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  216

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  217
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  217

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  218
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  218

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  219
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  219

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  220
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  220

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  221
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  221

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  222
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  222

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  223
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  223

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  224
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  224

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  225
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  225

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  226
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  226

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  227
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  227

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  228
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  228

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  229
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  229

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  230
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  230

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  231
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  231

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  232
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  232

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  233
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  233

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  234
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  234

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  235
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  235

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  236
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  236

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  237
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  237

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  238
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  238

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  239
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  239

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  240
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  240

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  241
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  241

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  242
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  242

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  243
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  243

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  244
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  244

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  245
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  245

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  246
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  246

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  247
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  247

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  248
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  248

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  249
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  249

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  250
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  250

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  251
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  251

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  252
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  252

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  253
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  253

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  254
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  254

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  255
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  255

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  256
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  256

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  257
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  257

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  258
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  258

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  259
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  259

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  260
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chrains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  260

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  261
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  261

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  262
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  262

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  263
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  263

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  264
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  264

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  265
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  265

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  266
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring betwee side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  266

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  267
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  267

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  268
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  268

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  269
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring betwee side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  269

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  270
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring betwee side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  270

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  271
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  271

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  272
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  272

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  273
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  273

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  274
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  274

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  275
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  275

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  276
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  276

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  277
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  277

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  278
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  278

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  279
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  279

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  280
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  280

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  281
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  281

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  282
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  282

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  283
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  283

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  284
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  284

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  285
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  285

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  286
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  286

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  287
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chain at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  287

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  288
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  288

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  289
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  289

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  290
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  290

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  291
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  291

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  292
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  292

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  293
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  293

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  294
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  294

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  295
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  295

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  296
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  296

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  297
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  297

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  298
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  298

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  299
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  299

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  300
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  300

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  301
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  301

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  302
<211>  29
<212>  PRT
<213>  Artificial Sequencce

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  302

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  303
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  303

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  304
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  304

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  305
<211>  29
<212>  PRT
<213>  Artificial Sequencce

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  305

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  306
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  306

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  307
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  307

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  308
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  308

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  309
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  309

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  310
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  310

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  311
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chain at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  311

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  312
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  312

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  313
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  313

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  314
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  314

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  315
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between seide chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  315

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  316
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  316

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  317
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 adn 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  317

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  318
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  318

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  319
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  319

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  320
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  320

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  321
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at position 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  321

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  322
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  322

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  323
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  323

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  324
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at position 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  324

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  325
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  325

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  326
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  326

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  327
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  327

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  328
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  328

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  329
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  329

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  330
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  330

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  331
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  331

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  332
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  332

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  333
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  333

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  334
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  334

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  335
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chainst at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  335

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  336
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  336

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  337
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  337

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  338
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam right between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  338

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  339
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  339

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  340
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  340

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  341
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  341

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  342
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  342

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  343
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  343

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  344
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  344

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  345
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  345

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  346
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  346

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  347
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  347

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  348
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  348

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  349
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  349

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  350
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  350

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  351
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  351

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  352
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  352

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  353
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  353

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  354
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  354

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  355
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  355

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  356
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  356

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  357
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  357

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  358
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  358

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  359
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  359

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  360
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  360

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  361
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  361

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  362
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  362

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  363
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  363

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  364
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  364

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  365
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  365

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  366
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  366

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  367
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  367

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  368
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  368

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  369
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  369

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  370
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  370

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  371
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  371

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  372
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  372

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  373
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  373

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  374
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  374

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  375
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  375

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  376
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  376

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  377
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  377

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  378
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  378

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  379
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  379

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  380
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  380

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  381
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  381

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  382
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  382

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  383
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  383

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  384
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  384

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  385
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  385

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  386
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  386

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  387
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  387

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  388
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  388

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  389
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  389

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  390
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  390

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  391
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  391

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  392
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  392

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  393
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  393

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  394
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  394

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  395
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  395

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  396
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  396

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  397
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  397

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  398
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  398

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  399
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  399

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  400
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  400

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  401
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  401

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  402
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  402

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  403
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  403

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  404
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  404

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  405
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  405

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  406
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  406

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  407
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  407

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  408
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  c-term amidation

<400>  408

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  409
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  409

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  410
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  410

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  411
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  411

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  412
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  412

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  413
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  413

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  414
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  414

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  415
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  415

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  416
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  416

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  417
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  417

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  418
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  418

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  419
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  419

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  420
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  420

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  421
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  421

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  422
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  422

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  423
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  423

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  424
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  424

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  425
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  425

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  426
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  426

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  427
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  427

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  428
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  428

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  429
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  429

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  430
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  430

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  431
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  431

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  432
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  432

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  433
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  433

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  434
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  434

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  435
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  435

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  436
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  436

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  437
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 16 and 20

<400>  437

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  438
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  438

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  439
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  439

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  440
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  440

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  441
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  441

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  442
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  442

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  443
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  443

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  444
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  444

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  445
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  445

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  446
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  446

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  447
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  447

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  448
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  448

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  449
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  449

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  450
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  450

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  451
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  451

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  452
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  C-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  452

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  453
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  453

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  454
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  454

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  455
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  455

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  456
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  456

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  457
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  457

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  458
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  458

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  459
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  459

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  460
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  460

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  461
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  461

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  462
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  462

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  463
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  463

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  464
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  464

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  465
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  465

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  466
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at postions 12 and 16

<400>  466

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  467
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  467

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  468
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  468

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  469
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  469

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  470
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  470

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  471
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  471

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  472
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  472

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  473
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  473

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  474
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  474

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  475
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  475

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  476
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  476

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  477
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  477

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  478
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  478

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  479
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  479

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  480
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  480

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  481
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  481

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  482
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  482

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  483
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  483

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  484
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  484

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  485
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  485

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  486
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  486

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  487
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  487

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  488
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  488

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  489
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  489

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  490
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  490

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  491
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  491

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  492
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  492

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  493
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  493

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  494
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  494

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  495
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  495

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  496
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  496

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  497
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  497

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  498
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  498

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr Ala 
            20                  25                  30  


<210>  499
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  499

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  500
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  500

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  501
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  501

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  502
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  502

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  503
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  503

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  504
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  504

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  505
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  505

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  506
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethly Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethly Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  506

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  507
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  507

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  508
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  508

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  509
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  509

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  510
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  510

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  511
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  511

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  512
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  512

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  513
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  513

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  514
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  514

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  515
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  515

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  516
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Cys-PEG

<400>  516

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10          


<210>  517
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  517

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  518
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  518

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  519
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethly Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  519

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  520
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  520

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  521
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  521

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  522
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  522

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  523
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  523

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  524
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  524

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  525
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  525

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  526
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  526

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  527
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  527

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210>  528
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  528

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  529
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  529

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  530
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  530

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  531
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  531

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  532
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Cys-PEG

<400>  532

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys Cys 
        35                  40      


<210>  533
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  c-term amidation

<400>  533

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  534
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C8 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C8 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  534

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  535
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C14 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C14 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  535

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  536
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C16 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  536

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  537
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  537

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  538
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  538

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  539
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  539

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  540
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C18

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C18 fatty acid

<400>  540

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  541
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C16 Cys24-40K

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  541

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  542
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acid

<400>  542

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  543
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<400>  543

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  544
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acid

<400>  544

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  545
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  545

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  546
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C16 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  546

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  547
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  547

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  548
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  548

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  549
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16 amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Glu residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  549

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  550
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 truncated by one amino acid

<400>  550

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn 
            20                  25              


<210>  551
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 truncated by two amino acids

<400>  551

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met 
            20                  25          


<210>  552
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  aa 1-28, E16 K20 C-terminal amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  552

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn 
            20                  25              


<210>  553
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  aa 1-27 E16 K20 C-terminal amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  553

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Lys Met 
            20                  25          


<210>  554
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Norleucine

<400>  554

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  555
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  mt-138

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridging side chains at positions 16 and 20

<400>  555

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  556
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 with AIB at 16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  556

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  557
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  557

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  558
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  558

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  559
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutric Acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutric Acid

<400>  559

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  560
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  560

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  561
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aminoisobutyric acid

<400>  561

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  562
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  562

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  563
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 50

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  563

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  564
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 82

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  564

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  565
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 83

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  565

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  566
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 84

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  566

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  567
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 85

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via 6-aminohexanoic acid 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  567

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  568
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 86

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Leu-Leu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  568

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  569
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 87

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Pro-Pro spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  569

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  570
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 77*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  570

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  571
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 78*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  571

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  572
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 78

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  572

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  573
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 81*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  573

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  574
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 81

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  574

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  575
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 79*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  575

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  576
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide 80*

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  576

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  577
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  gamma-Glu-gamma-Glu C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  577

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  578
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  gamma-Glu-gamma-Glu-C16 Glucagon Amide

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  578

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  579
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  AA-C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<400>  579

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  580
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2, AIB2, Lys10, Cys24-PEG

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  580

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  581
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C14 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<400>  581

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  582
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C14)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<400>  582

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  583
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C16 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<400>  583

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  584
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C16)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  584

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  585
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Chimera 2-AIB2-K10-acylated

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  585

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  586
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Chimera 2-AIB2-K30-acylated

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C18 fatty acyl group

<400>  586

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  587
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<400>  587

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  588
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  588

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  589
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<400>  589

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  590
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  590

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  591
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide J

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  591

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  592
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide K

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  592

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  593
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  593

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  594
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetamidomethyl-cysteine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  594

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  595
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  595

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  596
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is carbamoyldiaminopropanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  596

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  597
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  597

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  598
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methionine sulfoxide

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  598

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  599
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Acetylornithine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  599

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  600
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  600

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  601
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  601

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  602
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  602

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  603
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  603

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Glu 
            20                  25                  


<210>  604
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  604

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  605
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  605

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ser Asp Phe Val Ser Trp Leu Leu Asp Glu 
            20                  25                  


<210>  606
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  606

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 
            20                  25                  


<210>  607
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  607

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  608
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  608

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  609
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  609

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  610
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  610

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  611
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  611

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  612
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  612

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  613
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<400>  613

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  614
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<400>  614

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  615
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C18 fatty acyl group

<400>  615

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  616
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  616

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  617
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  617

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  618
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  618

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  619
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  619

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  620
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covelently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  620

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  621
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  621

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  622
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  622

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  623
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  beta-Ala-beta-Ala - C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<400>  623

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  624
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera-2 Aib2C24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  624

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  625
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera-2 Aib2E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of the amino acids at positions 
       16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  625

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  626
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2E16K20lactamC24amideMal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  626

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  627

<400>  627
000

<210>  628
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  628

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  629
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<400>  629

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  630
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24thioether40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at position 16 and
       20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  630

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  631
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera2 Aib2E3C24-Thioether40K PEG(NOF)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  631

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  632
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  632

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  633
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16C24K10(rErE-C16) C24PEG40K amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  633

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  634
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(AA-C14)C24PEG40K TE amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  634

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  635
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(AA-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  635

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  636
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(rErE-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  636

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  637
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  637

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  638
caaggtccag ggaggttgtg                                                   20


<210>  639
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  639
ccaaaggtaa gctgtccata agga                                              24


<210>  640
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  640
ctctcccaag agtcacatgt cc                                                22


<210>  641
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  641
caataactcg gtcccctaca ac                                                22


<210>  642
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  642

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  643
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  643

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  644
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  644

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  645
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  645

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  646
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  646

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  647
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  647

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  648
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  648

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  649
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  649

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  650
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  650

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  651
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  651

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  652
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  652

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  653
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  653

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  654
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  654

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  655
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  655

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  656
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  656

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


