
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Belani, Rajesh
      Watkins, Jeffry Dean
      Zhang, Wei
      Vasserot, Alain Philippe

<120> THROMBOPOIETIC ACTIVITY OF TYROSYL-tRNA
  SYNTHETASE POLYPEPTIDES
  

<130> 120161.409PC

<140> PCT                  
<141> 2009-06-10  

<160> 15

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 528
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala
    370                 375                 380                 
Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg
385                 390                 395                 400 
Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln
                405                 410                 415     
Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg
            420                 425                 430         
Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile
        435                 440                 445             
Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly
    450                 455                 460                 
Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu
465                 470                 475                 480 
Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys
                485                 490                 495     
Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr
            500                 505                 510         
Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
        515                 520                 525             


<210> 2
<211> 528
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Ala Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala
    370                 375                 380                 
Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg
385                 390                 395                 400 
Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln
                405                 410                 415     
Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg
            420                 425                 430         
Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile
        435                 440                 445             
Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly
    450                 455                 460                 
Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu
465                 470                 475                 480 
Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys
                485                 490                 495     
Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr
            500                 505                 510         
Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
        515                 520                 525             


<210> 3
<211> 364
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile
        355                 360                 


<210> 4
<211> 1683
<212> DNA
<213> Homo sapiens

<400> 4
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtg tgaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctgt gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggcc ctgccaagaa ttcagaacca 1080
gaggaggtca tcccatcccg gctggatatc cgtgtgggga aaatcatcac tgtggagaag 1140
cacccagatg cagacagcct gtatgtagag aagattgacg tgggggaagc tgaaccacgg 1200
actgtggtga gcggcctggt acagttcgtg cccaaggagg aactgcagga caggctggta 1260
gtggtgctgt gcaacctgaa accccagaag atgagaggag tcgagtccca aggcatgctt 1320
ctgtgtgctt ctatagaagg gataaaccgc caggttgaac ctctggaccc tccggcaggc 1380
tctgctcctg gtgagcacgt gtttgtgaag ggctatgaaa agggccaacc agatgaggag 1440
ctcaagccca agaagaaagt cttcgagaag ttgcaggctg acttcaaaat ttctgaggag 1500
tgcatcgcac agtggaagca aaccaacttc atgaccaagc tgggctccat ttcctgtaaa 1560
tcgctgaaag gggggaacat tagctagcca gcccagcatc ttcccccctt cttccaccac 1620
tgagtcatct gctgtctctt cagtctgctc catccatcac ccatttaccc atctctcagg 1680
aca                                                               1683

<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> C-terminal tag

<400> 5
Leu Glu His His His His His His
 1               5              


<210> 6
<211> 348
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1, 2, 3, 4, 5, 6, 7, 8, 9
<223> Xaa = Any Amino Acid

<400> 6
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Ile Phe Thr Phe Ala Glu
 1               5                  10                  15      
Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val His Leu Met Asn
            20                  25                  30          
Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser Glu Glu
        35                  40                  45              
Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys Lys Lys
    50                  55                  60                  
Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn Gly Val
65                  70                  75                  80  
Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu Phe Val
                85                  90                  95      
Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr
            100                 105                 110         
Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp
        115                 120                 125             
Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile
    130                 135                 140                 
Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala
145                 150                 155                 160 
Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys
                165                 170                 175     
Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val
            180                 185                 190         
Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr
        195                 200                 205             
Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser
    210                 215                 220                 
Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val
225                 230                 235                 240 
Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser
                245                 250                 255     
Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val
            260                 265                 270         
Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe
        275                 280                 285             
Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys
    290                 295                 300                 
Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu
305                 310                 315                 320 
Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser
                325                 330                 335     
Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
            340                 345             


<210> 7
<211> 2178
<212> DNA
<213> Homo sapiens

<400> 7
ttcagaaagt ggtggaggga agacttcctt tttcccagag acagaaggtt atgcacccag 60
tggcctggga ccattgttct gggctttttt tcccttcgac atggatttgc ttctcactgt 120
gtaccccaac caccaaaacc accctgagat caatgctggt gctcctgcat cagatggctt 180
agagatcctt ccacctctta acacaagcat ctaggtccac tttactcaaa tctggcctca 240
gttgagagca gagtatacca tcagagccca ttctcctgtc tgctgtctgg gacgtggaaa 300
gaaagttagc tctagggggt ctttccaggg gcctctgtaa ggactggatg ctcctttccg 360
gaatccaaga gttcaccagg ctgcttctct aatggacgat gatcctcttc ctcctgacgt 420
ctctccctgg cagcacccag atgcagacag cctgtatgta gagaagattg acgtggggga 480
agctgaacca cggactgtgg tgagcggcct ggtacagttc gtgcccaagg aggaactgca 540
ggacaggctg gtagtggtgc tgtgcaacct gaaaccccag aagatgagag gagtcgagtc 600
ccaaggcatg cttctgtgtg cttctatgtg agtgaggact tggagtgggg cacaggacct 660
ggggaggcca ggaagagtag ggaatcagcc catatgatgt ccttccacac accaggtgga 720
agctctgaga acacgtgcct cttccttgct gatgccaaaa gttgatgcat gaaggactta 780
tcgtacaagt actgttaatg aagcatttta cctacagtta attttgttaa aatagaaatg 840
gagggctcaa accagtacat acccaagtct tactactagt aaggagtgga gcagggattc 900
aaatcccagt tttgatgtct ataaagtcct cgctacgtta ttttatactt cctcccctag 960
aaacacagat tttggtatct tgacacacaa ttttggtata gcctgggtta atgtaaccct 1020
ggtgatatgc agggatgtag caagataaga ggacctcctg gggctctggt actgaggatg 1080
ccctaaatcc catcagggcc cctgtgtaaa ggcccggatt gctttggcct ccacagtcac 1140
tggaacccat ccatagcctc actcttctct tgtcctgtgt cttcccagag aagggataaa 1200
ccgccaggtt gaacctctgg accctccggc aggctctgct cctggtgagc acgtgtttgt 1260
gaagggctat gaaaagggcc aaccagatga ggagctcaag cccaagagga aagtcttcga 1320
gaagttgcag gctgacttca aaatttctga ggagtgcatc gcacagtgga agcaaaccaa 1380
cttcatgacc aagctgggct ccatttcctg taaatcgctg aaagggggga acattagcta 1440
gccagcccag catcttcccc ccttcttcca ccactgagtc atctgctgtc tcttcagtct 1500
gctccaccca tcacccattt acccatctct caggacacgg aagcagcggg tttggactct 1560
ttattcggtg cagaactcgg caaggggcag cttaccctcc ccagaaccca ggatcatcct 1620
gtctggctgc agtgagagac caacccctaa caagggctgg gccacagcag ggagtccagc 1680
cctaccttct tcccttggca gctggagaaa tctggtttca atataactca tttaaaaatt 1740
tatgccacag tccttataat tggaaaaata ctggtgccca ggttttcttg gagttatcca 1800
agcagctgcg cccctagctg ggatctggta cctggactag gctaattaca gcttctcccc 1860
aacaggaaac tgtgggattt gaaaaggaaa gggaagggaa aacagagaac ctagtggtct 1920
accaagtggt tggcaacttt cccaatgtct gcttactctg aggcttggca ctgggggcca 1980
gggcctgccc cagggctcct ggaatttccc ttgatccagc taggctggga cactccctaa 2040
atcagctgcg tgttgttagc atcaggcaga atgaatggca gagagtgatt ctgtcttcat 2100
agagggtggg gtacttctcc ataaggcatc tcagtcaaat ccccatcact gtcataaatt 2160
caaataaaat gtctgaac                                               2178

<210> 8
<211> 388
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365,
366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377,
378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388
<223> Xaa = Any Amino Acid

<400> 8
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        355                 360                 365             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    370                 375                 380                 
Xaa Xaa Xaa Xaa
385             


<210> 9
<211> 1167
<212> DNA
<213> Homo sapiens

<400> 9
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtg tgaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctgt gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggcc tgccaagaat tcagaaccag 1080
aggaggtcat cccatcccgg ctggatatcc gtgtggggaa aatcatcact gtggagaagc 1140
acccagatgc agacagcctg tatgtag                                     1167

<210> 10
<211> 318
<212> PRT
<213> Homo sapiens

<400> 10
Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser
 1               5                  10                  15      
Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys
            20                  25                  30          
Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn
        35                  40                  45              
Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu
    50                  55                  60                  
Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr
65                  70                  75                  80  
Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val His Pro
                85                  90                  95      
Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp
            100                 105                 110         
Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser
        115                 120                 125             
Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro
    130                 135                 140                 
Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile
145                 150                 155                 160 
Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser
                165                 170                 175     
Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val
            180                 185                 190         
Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg
        195                 200                 205             
Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val
    210                 215                 220                 
Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg
225                 230                 235                 240 
Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His
                245                 250                 255     
Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys
            260                 265                 270         
Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser
        275                 280                 285             
Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu
    290                 295                 300                 
Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
305                 310                 315             


<210> 11
<211> 1736
<212> DNA
<213> Homo sapiens

<400> 11
gaaagatttt cacctttgca gagaagtacc tccctgcact tggctattca aaacgggtcc 60
atctgatgaa tcctatggtt ccaggattaa caggcagcaa aatgagctct tcagaagagg 120
agtccaagat tgatctcctt gatcggaagg aggatgtgaa gaaaaaactg aagaaggcct 180
tctgtgagcc aggaaatgtg gagaacaatg gggttctgtc cttcatcaag catgtccttt 240
ttccccttaa gtccgagttt gtgatcctac gagatgagaa atggggtgga aacaaaacct 300
acacagctta cgtggacctg gaaaaggact ttgctgctga ggttgtacat cctggagacc 360
tgaagaattc tgttgaagtc gcactgaaca agttgctgga tccaatccgg gaaaagttta 420
atacccctgc cctgaaaaaa ctggccagcg ctgcctaccc agatccctca aagcagaagc 480
caatggccaa aggccctgcc aagaattcag aaccagagga ggtcatccca tcccggctgg 540
atatccgtgt ggggaaaatc atcactgtgg agaagcaccc agatgcagac agcctgtatg 600
tagagaagat tgacgtgggg gaagctgaac cacggactgt ggtgagcggc ctggtacagt 660
tcgtgcccaa ggaggaactg caggacaggc tggtagtggt gctgtgcaac ctgaaacccc 720
agaagatgag aggagtcgag tcccaaggca tgcttctgtg tgcttctata gaagggataa 780
accgccaggt tgaacctctg gaccctccgg caggctctgc tcctggtgag cacgtgtttg 840
tgaagggcta tgaaaagggc caaccagatg aggagctcaa gcccaagaag aaagtcttcg 900
agaagttgca ggctgacttc aaaatttctg aggagtgcat cgcacagtgg aagcaaacca 960
acttcatgac caagctgggc tccatttcct gtaaatcgct gaaagggggg aacattagct 1020
agccagccca gcatcttccc cccttcttcc accactgagt catctgctgt ctcttcagtc 1080
tgctccatcc atcacccatt tacccatctc tcaggacacg gaagcagcgg gtttggactc 1140
tttattcggt gcagaactcg gcaaggggca gcttaccctc cccagaaccc aggatcatcc 1200
tgtctggctg cagtgagaga ccaaccccta acaagggctg ggccacagca gggagtccag 1260
ccctaccttc ttcccttggc agctggagaa atctggtttc aatataactc atttaaaaat 1320
ttatgccaca gtccttataa ttggaaaaat actggtgccc aggttttctt ggagttatcc 1380
aagcagctgc gcccctagct gggatctggt acctggacta ggctaattac agcttctccc 1440
caacaggaaa ctgtgggatt tgaaaaggaa agggaaggga aaacagagaa cctagtggtc 1500
taccaagtgg ttggcaactt tcccaatgtc tgcttactct gaggcttggc actgggggcc 1560
agggcctgcc ccagggctcc tggaatttcc cttgatccag ctaggctggg acactcccta 1620
aatcagctgc gtgttgttag catcaggcag aatgaatggc agagagtgat tctgtcttca 1680
tagagggtgg ggtacttctc cataaggcat ctcagtcaaa tccccatcac tgtcat     1736

<210> 12
<211> 179
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro
 1               5                  10                  15      
Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His
            20                  25                  30          
Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala
        35                  40                  45              
Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu
    50                  55                  60                  
Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln
65                  70                  75                  80  
Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile
                85                  90                  95      
Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser
            100                 105                 110         
Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro
        115                 120                 125             
Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala
    130                 135                 140                 
Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn
145                 150                 155                 160 
Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly
                165                 170                 175     
Asn Ile Ser
            


<210> 13
<211> 1167
<212> DNA
<213> Homo sapiens

<400> 13
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtg tgaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctgt gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggcc tgccaagaat tcagaaccag 1080
aggaggtcat cccatcccgg ctggatatcc gtgtggggaa aatcatcact gtggagaagc 1140
acccagatgc agacagcctg tatgtag                                     1167

<210> 14
<211> 188
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1, 2, 3, 4, 5, 6, 7, 8
<223> Xaa = Any Amino Acid

<400> 14
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Met Ala Lys Gly Pro Ala Lys
 1               5                  10                  15      
Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val
            20                  25                  30          
Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr
        35                  40                  45              
Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser
    50                  55                  60                  
Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val
65                  70                  75                  80  
Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser
                85                  90                  95      
Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val
            100                 105                 110         
Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe
        115                 120                 125             
Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys
    130                 135                 140                 
Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu
145                 150                 155                 160 
Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser
                165                 170                 175     
Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
            180                 185             


<210> 15
<211> 2262
<212> DNA
<213> Homo sapiens

<400> 15
gccagacaca gtggctcaca cctgtaatct taacactttg gaaggctgag gcaggcggat 60
cacttgagcc caaaagttag agaccaaaac ccagtctcta cccaaaaaaa aaaaaaaaaa 120
aaaaattagc caggcatagt agcacatgcc tgtagtccca gctacttggg aggctgaggt 180
gagaggatca cctgagcatg gggaagttga gactgcagtg agccatgatc gcaccactgc 240
actccagcct gggcaacaga gtgagactct atgtctcaaa aaaagaaaaa tgatagaaat 300
tagattagac ctattatacc caaccggtat atagggtatc gatagtttct tacacagctg 360
ttgggcagag cctgcagagc ttagagaagc ttatctttag attctcccag tttccttcta 420
tgtgcatggg cctggctctt agttggccat ccacttgtgc gtaatgctaa gatattggca 480
ttgatagctt tgtgcgaccc ttccagaaaa aaactcagta actcagtaaa attttttttt 540
ttttttctaa aagagacaga gtctggctct gttgcccagc ctggtcttga agtcctgggc 600
ttaagcaatc ctcccgtctc agcctcccaa agtgctagaa ttacaggtgt gagctaccac 660
acctggccaa gactcagtaa attctatgtg gaatgcatga atggaaatac ctaaaggagg 720
caaagctact actgctccct ccccgctagt ctaataattg agggagagaa cagatgaaaa 780
tcaggtatgt catgtctgaa aggttgccaa cccagtatta aagaagttac aactcagtgt 840
ttagactctg gggattctac actaaatctt acctaatctc agtgtcttaa cgtggtggga 900
tcagcagctg acctgccaca gggaagaatt ctacctcatg gggttcttct cattcccaga 960
gccaatggcc aaaggccctg ccaagaattc agaaccagag gaggtcatcc catcccggct 1020
ggatatccgt gtggggaaaa tcatcactgt ggagaagcac ccagatgcag acagcctgta 1080
tgtagagaag attgacgtgg gggaagctga accacggact gtggtgagcg gcctggtaca 1140
gttcgtgccc aaggaggaac tgcaggacag gctggtagtg gtgctgtgca acctgaaacc 1200
ccagaagatg agaggagtcg agtcccaagg catgcttctg tgtgcttcta tagaagggat 1260
aaaccgccag gttgaacctc tggaccctcc ggcaggctct gctcctggtg agcacgtgtt 1320
tgtgaagggc tatgaaaagg gccaaccaga tgaggagctc aagcccaaga agaaagtctt 1380
cgagaagttg caggctgact tcaaaatttc tgaggagtgc atcgcacagt ggaagcaaac 1440
caacttcatg accaagctgg gctccatttc ctgtaaatcg ctgaaagggg ggaacattag 1500
ctagccagcc cagcatcttc cccccttctt ccaccactga gtcatctgct gtctcttcag 1560
tctgctccat ccatcaccca tttacccatc tctcaggaca cggaagcagc gggtttggac 1620
tctttattcg gtgcagaact cggcaagggg cagcttaccc tccccagaac ccaggatcat 1680
cctgtctggc tgcagtgaga gaccaacccc taacaagggc tgggccacag cagggagtcc 1740
agccctacct tcttcccttg gcagctggag aaatctggtt tcaatataac tcatttaaaa 1800
atttatgcca cagtccttat aattggaaaa atactggtgc ccaggttttc ttggagttat 1860
ccaagcagct gcgcccctag ctgggatctg gtacctggac taggctaatt acagcttctc 1920
cccaacagga aactgtggga tttgaaaagg aaagggaagg gaaaacagag aacctagtgg 1980
tctaccaagt ggttggcaac tttcccaatg tctgcttact ctgaggcttg gcactggggg 2040
ccagggcctg ccccagggct cctggaattt cccttgatcc agctaggctg ggacactccc 2100
taaatcagct gcgtgttgtt agcatcaggc agaatgaatg gcagagagtg attctgtctt 2160
catagagggt ggggtacttc tccataaggc atctcagtca aatccccatc actgtcataa 2220
attcaaataa aatgtctgaa caagggaaaa aaaaaaaaaa aa                    2262
