                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  PEGYLATED INSULIN LISPRO COMPOUNDS

<130>  X-18199

<150>  61/061281
<151>  2008-06-13

<150>  61/121394
<151>  2008-12-10

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  HOMO SAPIENS

<400>  1

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  30
<212>  PRT
<213>  HOMO SAPIENS

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is absent

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is absent, Gly, Ser, Ala, or Asn

<400>  4

Xaa Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
1               5                   10                  15      


Leu Glu Asn Tyr Cys Xaa 
            20          


<210>  5
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Asn or Lys

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Pro, Asp, Lys, Leu, Val, Glu or Ala

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Lys or Pro

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is absent or Thr

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is absent, any amino acid, any basic amino 
       acid, or any genetically encodeable amino acid

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is absent, any amino acid, any basic amino 
       acid, or any genetically encodeable amino acid

<400>  5

Xaa Phe Val Xaa Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu 
1               5                   10                  15      


Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  6
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is absent, or any genetically encodeable amino 
       acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Asn or Lys

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Pro, Asp, Lys, Leu, Val, Glu or Ala

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Lys or Pro

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is absent or Thr

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is absent or any genetically encodeable amino 
       acid

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is absent or any genetically encodeable amino 
       acid.

<400>  6

Xaa Phe Val Xaa Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu 
1               5                   10                  15      


Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa 
    


