                         SEQUENCE LISTING

<110>  MacroGenics, Inc.
       Johnson, Leslie S. S
       Huang, Ling
 
<120>  BCR-Complex-Specific Antibodies And Methods of Using Same

<130>  1301.0020I

<150>  US 61/041,659
<151>  2008-04-02

<160>  38    

<170>  PatentIn version 3.4

<210>  1
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  1
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggggcttc agtgaagctg     60

tcctgcaagg cttctggcta caccttcacc agctactgga tgaactgggt gaagcagagg    120

cctggacaag gccttgaatg gattggtatg gttgatcctt cagacagtga aactcactac    180

aatcaaatgt tcaaggacaa ggccacattg actgttgaca aatcctccag cacagcctac    240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagagctatg    300

ggctactggg gtcaaggaac ctcagtcacc gtctcctca                           339


<210>  2
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  3
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  3
gatgttgtga tgacccagac tccactcact ttgtcggtta acattggaca accagcctcc     60

atctcttgta agtcaagtca gagcctctta gatactgatg gaaagacata tttgaattgg    120

ttgttacaga ggccaggcca gtctccaaac cgcctaatct atctggtgtc taaactggac    180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc    240

agcagagtgg aggctgagga tttgggaatt tattattgct ggcaaggtac acattttccg    300

ctcacgttcg gtgctgggac caagctggag ctgaaa                              336


<210>  4
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  5
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  5
gatgttgtgt tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc     60

atctcttgta agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg    120

ttgttacaga ggccaggtca gtctccaaag cgcctaatct atctggtgtc taaactggac    180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc    240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg    300

ctcacgttcg gtgctgggac caagctggag ctgaaa                              336


<210>  6
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Val Val Leu Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  7
<211>  339
<212>  PRT
<213>  Mus musculus

<400>  7

Cys Ala Gly Gly Thr Cys Cys Ala Ala Cys Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr Gly Ala Gly Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Gly Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr 
        35                  40                  45              


Thr Cys Ala Gly Thr Gly Ala Ala Gly Cys Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Ala Gly Cys Thr Ala Cys 
                85                  90                  95      


Thr Gly Gly Ala Thr Gly Ala Ala Cys Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Cys Ala Gly Ala Gly Gly Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Gly Gly Cys Cys Thr Thr Gly Ala Ala Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Thr Gly Ala Thr Thr Gly Ala Thr Cys Cys Thr Thr 
145                 150                 155                 160 


Cys Ala Gly Ala Cys Ala Gly Thr Gly Ala Ala Ala Cys Thr Cys Ala 
                165                 170                 175     


Cys Thr Ala Cys Ala Ala Thr Cys Ala Ala Ala Thr Gly Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Gly Ala Cys Ala Ala Gly Gly Cys Cys Ala Cys Ala Thr 
        195                 200                 205             


Thr Gly Ala Cys Thr Gly Thr Ala Gly Ala Cys Ala Ala Ala Thr Cys 
    210                 215                 220                 


Cys Thr Cys Cys Ala Gly Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Ala Thr Gly Cys Ala Gly Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Thr Cys 
            260                 265                 270         


Thr Gly Cys Gly Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Gly Gly Cys Thr 
    290                 295                 300                 


Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala Ala Cys 
305                 310                 315                 320 


Cys Thr Cys Ala Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys 
                325                 330                 335     


Thr Cys Ala 
            


<210>  8
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  9
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  9
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg    120

tttcagcaga ggccaggcca atctccaagg cgcctaattt atctggtgtc taaactggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgct ggcaaggtac acattttccg    300

ctcacgttcg gcggagggac caagcttgag atcaaa                              336


<210>  10
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  10

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  11
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  11
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg    120

tttctgcaga ggccaggcca atctccaagg cgcctaattt atctggtgtc taaactggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgct ggcaaggtac acattttccg    300

ctcacgttcg gcggagggac caagcttgag atcaaa                              336


<210>  12
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized Version of murine sequence

<400>  12

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  13
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg    120

tttcagcaga ggccaggcca atctccaaag cgcctaattt atctggtgtc taaactggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgct ggcaaggtac acattttccg    300

ctcacgttcg gcggagggac caagcttgag atcaaa                              336


<210>  14
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  14

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  15
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg    120

tttcagcaga ggccaggcca atctccaaac cgcctaattt atctggtgtc taaactggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgct ggcaaggtac acattttccg    300

ctcacgttcg gcggagggac caagcttgag atcaaa                              336


<210>  16
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  16

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequences

<400>  17
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg    120

tttctgcaga ggccaggcca atctccaaag cgcctaattt atctggtgtc taaactggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgct ggcaaggtac acattttccg    300

ctcacgttcg gcggagggac caagcttgag atcaaa                              336


<210>  18
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  18

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  19
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  19
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg    120

tttctgcaga ggccaggcca atctccaaac cgcctaattt atctggtgtc taaactggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgct ggcaaggtac acattttccg    300

ctcacgttcg gcggagggac caagcttgag atcaaa                              336


<210>  20
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  20

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  21
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggcgcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctactgga tgaactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaatg attgatcctt cagacagtga aactcactac    180

aatcaaatgt tcaaggacag agtcaccatg accacagaca catccacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagctatg    300

ggctactggg ggcaagggac cacggtcacc gtctcctca                           339


<210>  22
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  23
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  23
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggcgcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctactgga tgaactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatcggaatg attgatcctt cagacagtga aactcactac    180

aatcaaatgt tcaaggacag agtcaccatg accacagaca catccacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagctatg    300

ggctactggg ggcaagggac cacggtcacc gtctcctca                           339


<210>  24
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  25
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  25
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggcgcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctactgga tgaactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaatg attgatcctt cagacagtga aactcactac    180

aatcaaatgt tcaaggacaa agccaccctg accgtagaca catccacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagctatg    300

ggctactggg ggcaagggac cacggtcacc gtctcctca                           339


<210>  26
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  27
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  27
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggcgcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctactgga tgaactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaatg attgatcctt cagacagtga aactcactac    180

aatcaaatgt tcaaggacag agtcaccatg accgtagaca catccacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagctatg    300

ggctactggg ggcaagggac cacggtcacc gtctcctca                           339


<210>  28
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  29
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  29
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggcgcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctactgga tgaactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaatg attgatcctt cagacagtga aactcactac    180

aatcaaatgt tcaaggacag agtcaccatg accgtagaca aatccacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagctatg    300

ggctactggg ggcaagggac cacggtcacc gtctcctca                           339


<210>  30
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  31
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  31
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggcgcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctactgga tgaactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaatg attgatcctt cagacagtga aactcactac    180

aatcaaaagt tcaaggacag agtcaccatg accacagaca catccacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagctatg    300

ggctactggg ggcaagggac cacggtcacc gtctcctca                           339


<210>  32
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  33
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  33
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggcgcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctactgga tgaactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatcggaatg attgatcctt cagacagtga aactcactac    180

aatcaaaagt tcaaggacag agtcaccatg accacagaca catccacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagctatg    300

ggctactggg ggcaagggac cacggtcacc gtctcctca                           339


<210>  34
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  35
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  35
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggcgcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctactgga tgaactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatcggaatg attgatcctt cagacagtga aactcactac    180

aatcaaatgt tcaaggacag agtcaccatg accgtagaca catccacgag cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagctatg    300

ggctactggg ggcaagggac cacggtcacc gtctcctca                           339


<210>  36
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  37
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  37

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gln Gly Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  38
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized version of murine sequence

<400>  38

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


