                         SEQUENCE LISTING

<110>  Koninklijke Philips Electronics N. V.
 
<120>  Therapy Delivery and Monitoring using a gene of interest-reporter
        fusion protein and optical imaging

<130>  PH009790

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  928
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene Rb

<400>  1

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
            20                  25                  30          


Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
        35                  40                  45              


Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
    50                  55                  60                  


Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
65                  70                  75                  80  


Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                85                  90                  95      


Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
            100                 105                 110         


Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
        115                 120                 125             


His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
    130                 135                 140                 


Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
145                 150                 155                 160 


Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                165                 170                 175     


Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
            180                 185                 190         


Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
        195                 200                 205             


Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
    210                 215                 220                 


Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
225                 230                 235                 240 


Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                245                 250                 255     


Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
            260                 265                 270         


Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
        275                 280                 285             


Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
    290                 295                 300                 


Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
305                 310                 315                 320 


Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                325                 330                 335     


Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
            340                 345                 350         


Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
        355                 360                 365             


Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
    370                 375                 380                 


Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
385                 390                 395                 400 


Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                405                 410                 415     


Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
            420                 425                 430         


Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
        435                 440                 445             


Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
    450                 455                 460                 


Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
465                 470                 475                 480 


Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                485                 490                 495     


Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
            500                 505                 510         


Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
        515                 520                 525             


Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
    530                 535                 540                 


Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
545                 550                 555                 560 


Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                565                 570                 575     


Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
            580                 585                 590         


Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
        595                 600                 605             


Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
    610                 615                 620                 


Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                645                 650                 655     


Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
            660                 665                 670         


His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
        675                 680                 685             


Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
    690                 695                 700                 


Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
705                 710                 715                 720 


Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                725                 730                 735     


Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
            740                 745                 750         


Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
        755                 760                 765             


Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
    770                 775                 780                 


Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
785                 790                 795                 800 


Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                805                 810                 815     


Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
            820                 825                 830         


Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
        835                 840                 845             


Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
    850                 855                 860                 


Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
865                 870                 875                 880 


Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                885                 890                 895     


Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
            900                 905                 910         


Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
        915                 920                 925             


<210>  2
<211>  442
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene CADM1

<400>  2

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
        355                 360                 365             


Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
    370                 375                 380                 


Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
385                 390                 395                 400 


Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                405                 410                 415     


Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
            420                 425                 430         


Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440         


<210>  3
<211>  440
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene ZMYND10

<400>  3

Met Gly Asp Leu Glu Leu Leu Leu Pro Gly Glu Ala Glu Val Leu Val 
1               5                   10                  15      


Arg Gly Leu Arg Ser Phe Pro Leu Arg Glu Met Gly Ser Glu Gly Trp 
            20                  25                  30          


Asn Gln Gln His Glu Asn Leu Glu Lys Leu Asn Met Gln Ala Ile Leu 
        35                  40                  45              


Asp Ala Thr Val Ser Gln Gly Glu Pro Ile Gln Glu Leu Leu Val Thr 
    50                  55                  60                  


His Gly Lys Val Pro Thr Leu Val Glu Glu Leu Ile Ala Val Glu Met 
65                  70                  75                  80  


Trp Lys Gln Lys Val Phe Pro Val Phe Cys Arg Val Glu Asp Phe Lys 
                85                  90                  95      


Pro Gln Asn Thr Phe Pro Ile Tyr Met Val Val His His Glu Ala Ser 
            100                 105                 110         


Ile Ile Asn Leu Leu Glu Thr Val Phe Phe His Lys Glu Val Cys Glu 
        115                 120                 125             


Ser Ala Glu Asp Thr Val Leu Asp Leu Val Asp Tyr Cys His Arg Lys 
    130                 135                 140                 


Leu Thr Leu Leu Val Ala Gln Ser Gly Cys Gly Gly Pro Pro Glu Gly 
145                 150                 155                 160 


Glu Gly Ser Gln Asp Ser Asn Pro Met Gln Glu Leu Gln Lys Gln Ala 
                165                 170                 175     


Glu Leu Met Glu Phe Glu Ile Ala Leu Lys Ala Leu Ser Val Leu Arg 
            180                 185                 190         


Tyr Ile Thr Asp Cys Val Asp Ser Leu Ser Leu Ser Thr Leu Ser Arg 
        195                 200                 205             


Met Leu Ser Thr His Asn Leu Pro Cys Leu Leu Val Glu Leu Leu Glu 
    210                 215                 220                 


His Ser Pro Trp Ser Arg Arg Glu Gly Gly Lys Leu Gln Gln Phe Glu 
225                 230                 235                 240 


Gly Ser Arg Trp His Thr Val Ala Pro Ser Glu Gln Gln Lys Leu Ser 
                245                 250                 255     


Lys Leu Asp Gly Gln Val Trp Ile Ala Leu Tyr Asn Leu Leu Leu Ser 
            260                 265                 270         


Pro Glu Ala Gln Ala Arg Tyr Cys Leu Thr Ser Phe Ala Lys Gly Arg 
        275                 280                 285             


Leu Leu Lys Leu Arg Ala Phe Leu Thr Asp Thr Leu Leu Asp Gln Leu 
    290                 295                 300                 


Pro Asn Leu Ala His Leu Gln Ser Phe Leu Ala His Leu Thr Leu Thr 
305                 310                 315                 320 


Glu Thr Gln Pro Pro Lys Lys Asp Leu Val Leu Glu Gln Ile Pro Glu 
                325                 330                 335     


Ile Trp Glu Arg Leu Glu Arg Glu Asn Arg Gly Lys Trp Gln Ala Ile 
            340                 345                 350         


Ala Lys His Gln Leu Gln His Val Phe Ser Pro Ser Glu Gln Asp Leu 
        355                 360                 365             


Arg Leu Gln Ala Arg Arg Trp Ala Glu Thr Tyr Arg Leu Asp Val Leu 
    370                 375                 380                 


Glu Ala Val Ala Pro Glu Arg Pro Arg Cys Ala Tyr Cys Ser Ala Glu 
385                 390                 395                 400 


Ala Ser Lys Arg Cys Ser Arg Cys Gln Asn Glu Trp Tyr Cys Cys Arg 
                405                 410                 415     


Glu Cys Gln Val Lys His Trp Glu Lys His Gly Lys Thr Cys Val Leu 
            420                 425                 430         


Ala Ala Gln Gly Asp Arg Ala Lys 
        435                 440 


<210>  4
<211>  418
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene RASSF5

<400>  4

Met Ala Met Ala Ser Pro Ala Ile Gly Gln Arg Pro Tyr Pro Leu Leu 
1               5                   10                  15      


Leu Asp Pro Glu Pro Pro Arg Tyr Leu Gln Ser Leu Ser Gly Pro Glu 
            20                  25                  30          


Leu Pro Pro Pro Pro Pro Asp Arg Ser Ser Arg Leu Cys Val Pro Ala 
        35                  40                  45              


Pro Leu Ser Thr Ala Pro Gly Ala Arg Glu Gly Arg Ser Ala Arg Arg 
    50                  55                  60                  


Ala Ala Arg Gly Asn Leu Glu Pro Pro Pro Arg Ala Ser Arg Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Arg Pro Gly Leu Gln Gln Arg Leu Arg Arg Arg Pro Gly 
                85                  90                  95      


Ala Pro Arg Pro Arg Asp Val Arg Ser Ile Phe Glu Gln Pro Gln Asp 
            100                 105                 110         


Pro Arg Val Pro Ala Glu Arg Gly Glu Gly His Cys Phe Ala Glu Leu 
        115                 120                 125             


Val Leu Pro Gly Gly Pro Gly Trp Cys Asp Leu Cys Gly Arg Glu Val 
    130                 135                 140                 


Leu Arg Gln Ala Leu Arg Cys Thr Asn Cys Lys Phe Thr Cys His Pro 
145                 150                 155                 160 


Glu Cys Arg Ser Leu Ile Gln Leu Asp Cys Ser Gln Gln Glu Gly Leu 
                165                 170                 175     


Ser Arg Asp Arg Pro Ser Pro Glu Ser Thr Leu Thr Val Thr Phe Ser 
            180                 185                 190         


Gln Asn Val Cys Lys Pro Val Glu Glu Thr Gln Arg Pro Pro Thr Leu 
        195                 200                 205             


Gln Glu Ile Lys Gln Lys Ile Asp Ser Tyr Asn Thr Arg Glu Lys Asn 
    210                 215                 220                 


Cys Leu Gly Met Lys Leu Ser Glu Asp Gly Thr Tyr Thr Gly Phe Ile 
225                 230                 235                 240 


Lys Val His Leu Lys Leu Arg Arg Pro Val Thr Val Pro Ala Gly Ile 
                245                 250                 255     


Arg Pro Gln Ser Ile Tyr Asp Ala Ile Lys Glu Val Asn Leu Ala Ala 
            260                 265                 270         


Thr Thr Asp Lys Arg Thr Ser Phe Tyr Leu Pro Leu Asp Ala Ile Lys 
        275                 280                 285             


Gln Leu His Ile Ser Ser Thr Thr Thr Val Ser Glu Val Ile Gln Gly 
    290                 295                 300                 


Leu Leu Lys Lys Phe Met Val Val Asp Asn Pro Gln Lys Phe Ala Leu 
305                 310                 315                 320 


Phe Lys Arg Ile His Lys Asp Gly Gln Val Leu Phe Gln Lys Leu Ser 
                325                 330                 335     


Ile Ala Asp Arg Pro Leu Tyr Leu Arg Leu Leu Ala Gly Pro Asp Thr 
            340                 345                 350         


Glu Val Leu Ser Phe Val Leu Lys Glu Asn Glu Thr Gly Glu Val Glu 
        355                 360                 365             


Trp Asp Ala Phe Ser Ile Pro Glu Leu Gln Asn Phe Leu Thr Ile Leu 
    370                 375                 380                 


Glu Lys Glu Glu Gln Asp Lys Ile Gln Gln Val Gln Lys Lys Tyr Asp 
385                 390                 395                 400 


Lys Phe Arg Gln Lys Leu Glu Glu Ala Leu Arg Glu Ser Gln Gly Lys 
                405                 410                 415     


Pro Gly 
        


<210>  5
<211>  403
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene PTEN

<400>  5

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  6
<211>  375
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene SERPINB5

<400>  6

Met Asp Ala Leu Gln Leu Ala Asn Ser Ala Phe Ala Val Asp Leu Phe 
1               5                   10                  15      


Lys Gln Leu Cys Glu Lys Glu Pro Leu Gly Asn Val Leu Phe Ser Pro 
            20                  25                  30          


Ile Cys Leu Ser Thr Ser Leu Ser Leu Ala Gln Val Gly Ala Lys Gly 
        35                  40                  45              


Asp Thr Ala Asn Glu Ile Gly Gln Val Leu His Phe Glu Asn Val Lys 
    50                  55                  60                  


Asp Ile Pro Phe Gly Phe Gln Thr Val Thr Ser Asp Val Asn Lys Leu 
65                  70                  75                  80  


Ser Ser Phe Tyr Ser Leu Lys Leu Ile Lys Arg Leu Tyr Val Asp Lys 
                85                  90                  95      


Ser Leu Asn Leu Ser Thr Glu Phe Ile Ser Ser Thr Lys Arg Pro Tyr 
            100                 105                 110         


Ala Lys Glu Leu Glu Thr Val Asp Phe Lys Asp Lys Leu Glu Glu Thr 
        115                 120                 125             


Lys Gly Gln Ile Asn Asn Ser Ile Lys Asp Leu Thr Asp Gly His Phe 
    130                 135                 140                 


Glu Asn Ile Leu Ala Asp Asn Ser Val Asn Asp Gln Thr Lys Ile Leu 
145                 150                 155                 160 


Val Val Asn Ala Ala Tyr Phe Val Gly Lys Trp Met Lys Lys Phe Pro 
                165                 170                 175     


Glu Ser Glu Thr Lys Glu Cys Pro Phe Arg Leu Asn Lys Thr Asp Thr 
            180                 185                 190         


Lys Pro Val Gln Met Met Asn Met Glu Ala Thr Phe Cys Met Gly Asn 
        195                 200                 205             


Ile Asp Ser Ile Asn Cys Lys Ile Ile Glu Leu Pro Phe Gln Asn Lys 
    210                 215                 220                 


His Leu Ser Met Phe Ile Leu Leu Pro Lys Asp Val Glu Asp Glu Ser 
225                 230                 235                 240 


Thr Gly Leu Glu Lys Ile Glu Lys Gln Leu Asn Ser Glu Ser Leu Ser 
                245                 250                 255     


Gln Trp Thr Asn Pro Ser Thr Met Ala Asn Ala Lys Val Lys Leu Ser 
            260                 265                 270         


Ile Pro Lys Phe Lys Val Glu Lys Met Ile Asp Pro Lys Ala Cys Leu 
        275                 280                 285             


Glu Asn Leu Gly Leu Lys His Ile Phe Ser Glu Asp Thr Ser Asp Phe 
    290                 295                 300                 


Ser Gly Met Ser Glu Thr Lys Gly Val Ala Leu Ser Asn Val Ile His 
305                 310                 315                 320 


Lys Val Cys Leu Glu Ile Thr Glu Asp Gly Gly Asp Ser Ile Glu Val 
                325                 330                 335     


Pro Gly Ala Arg Ile Leu Gln His Lys Asp Glu Leu Asn Ala Asp His 
            340                 345                 350         


Pro Phe Ile Tyr Ile Ile Arg His Asn Lys Thr Arg Asn Ile Ile Phe 
        355                 360                 365             


Phe Gly Lys Phe Cys Ser Pro 
    370                 375 


<210>  7
<211>  1087
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene EPB41L3

<400>  7

Met Thr Thr Glu Ser Gly Ser Asp Ser Glu Ser Lys Pro Asp Gln Glu 
1               5                   10                  15      


Ala Glu Pro Gln Glu Ala Ala Gly Ala Gln Gly Arg Ala Gly Ala Pro 
            20                  25                  30          


Val Pro Glu Pro Pro Lys Glu Glu Gln Gln Gln Ala Leu Glu Gln Phe 
        35                  40                  45              


Ala Ala Ala Ala Ala His Ser Thr Pro Val Arg Arg Glu Val Thr Asp 
    50                  55                  60                  


Lys Glu Gln Glu Phe Ala Ala Arg Ala Ala Lys Gln Leu Glu Tyr Gln 
65                  70                  75                  80  


Gln Leu Glu Asp Asp Lys Leu Ser Gln Lys Ser Ser Ser Ser Lys Leu 
                85                  90                  95      


Ser Arg Ser Pro Leu Lys Ile Val Lys Lys Pro Lys Ser Met Gln Cys 
            100                 105                 110         


Lys Val Ile Leu Leu Asp Gly Ser Glu Tyr Thr Cys Asp Val Glu Lys 
        115                 120                 125             


Arg Ser Arg Gly Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn 
    130                 135                 140                 


Leu Leu Glu Lys Asp Tyr Phe Gly Leu Thr Tyr Arg Asp Ala Glu Asn 
145                 150                 155                 160 


Gln Lys Asn Trp Leu Asp Pro Ala Lys Glu Ile Lys Lys Gln Val Arg 
                165                 170                 175     


Ser Gly Ala Trp His Phe Ser Phe Asn Val Lys Phe Tyr Pro Pro Asp 
            180                 185                 190         


Pro Ala Gln Leu Ser Glu Asp Ile Thr Arg Tyr Tyr Leu Cys Leu Gln 
        195                 200                 205             


Leu Arg Asp Asp Ile Val Ser Gly Arg Leu Pro Cys Ser Phe Val Thr 
    210                 215                 220                 


Leu Ala Leu Leu Gly Ser Tyr Thr Val Gln Ser Glu Leu Gly Asp Tyr 
225                 230                 235                 240 


Asp Pro Asp Glu Cys Gly Ser Asp Tyr Ile Ser Glu Phe Arg Phe Ala 
                245                 250                 255     


Pro Asn His Thr Lys Glu Leu Glu Asp Lys Val Ile Glu Leu His Lys 
            260                 265                 270         


Ser His Arg Gly Met Thr Pro Ala Glu Ala Glu Met His Phe Leu Glu 
        275                 280                 285             


Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys 
    290                 295                 300                 


Asp Ser Glu Gly Val Glu Ile Met Leu Gly Val Cys Ala Ser Gly Leu 
305                 310                 315                 320 


Leu Ile Tyr Arg Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys 
                325                 330                 335     


Val Leu Lys Ile Ser Tyr Lys Arg Asn Asn Phe Tyr Ile Lys Ile Arg 
            340                 345                 350         


Pro Gly Glu Phe Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro 
        355                 360                 365             


Asn His Arg Ala Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His 
    370                 375                 380                 


Thr Phe Phe Arg Leu Leu Leu Pro Glu Ala Pro Pro Lys Lys Phe Leu 
385                 390                 395                 400 


Thr Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr 
                405                 410                 415     


Arg Arg Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro Tyr Phe Glu Arg 
            420                 425                 430         


Ser Ser Ser Lys Arg Tyr Thr Met Ser Arg Ser Leu Asp Gly Glu Val 
        435                 440                 445             


Gly Thr Gly Gln Tyr Ala Thr Thr Lys Gly Ile Ser Gln Thr Asn Leu 
    450                 455                 460                 


Ile Thr Thr Val Thr Pro Glu Lys Lys Ala Glu Glu Glu Arg Asp Glu 
465                 470                 475                 480 


Glu Glu Asp Lys Arg Arg Lys Gly Glu Glu Val Thr Pro Ile Ser Ala 
                485                 490                 495     


Ile Arg His Glu Gly Lys Ser Pro Gly Leu Gly Thr Asp Ser Cys Pro 
            500                 505                 510         


Leu Ser Pro Pro Ser Thr His Cys Ala Pro Thr Ser Pro Thr Glu Leu 
        515                 520                 525             


Arg Arg Arg Cys Lys Glu Asn Asp Cys Lys Leu Pro Gly Tyr Glu Pro 
    530                 535                 540                 


Ser Arg Ala Glu His Leu Pro Gly Glu Pro Ala Leu Asp Ser Asp Gly 
545                 550                 555                 560 


Pro Gly Arg Pro Tyr Leu Gly Asp Gln Asp Val Ala Phe Ser Tyr Arg 
                565                 570                 575     


Gln Gln Thr Gly Lys Gly Thr Thr Leu Phe Ser Phe Ser Leu Gln Leu 
            580                 585                 590         


Pro Glu Ser Phe Pro Ser Leu Leu Asp Asp Asp Gly Tyr Leu Ser Phe 
        595                 600                 605             


Pro Asn Leu Ser Glu Thr Asn Leu Leu Pro Gln Ser Leu Gln His Tyr 
    610                 615                 620                 


Leu Pro Ile Arg Ser Pro Ser Leu Val Pro Cys Phe Leu Phe Ile Phe 
625                 630                 635                 640 


Phe Phe Leu Leu Ser Ala Ser Phe Ser Val Pro Tyr Ala Leu Thr Leu 
                645                 650                 655     


Ser Phe Pro Leu Ala Leu Cys Leu Cys Tyr Leu Glu Pro Lys Ala Ala 
            660                 665                 670         


Ser Leu Ser Ala Ser Leu Asp Asn Asp Pro Ser Asp Ser Ser Glu Glu 
        675                 680                 685             


Glu Thr Asp Ser Glu Arg Thr Asp Thr Ala Ala Asp Gly Glu Thr Thr 
    690                 695                 700                 


Ala Thr Glu Ser Asp Gln Glu Glu Asp Ala Glu Leu Lys Ala Gln Glu 
705                 710                 715                 720 


Leu Glu Lys Thr Gln Asp Asp Leu Met Lys His Gln Thr Asn Ile Ser 
                725                 730                 735     


Glu Leu Lys Arg Thr Phe Leu Glu Thr Ser Thr Asp Thr Ala Val Thr 
            740                 745                 750         


Asn Glu Trp Glu Lys Arg Leu Ser Thr Ser Pro Val Arg Leu Ala Ala 
        755                 760                 765             


Arg Gln Glu Asp Ala Pro Met Ile Glu Pro Leu Val Pro Glu Glu Thr 
    770                 775                 780                 


Lys Gln Ser Ser Gly Glu Lys Leu Met Asp Gly Ser Glu Ile Phe Ser 
785                 790                 795                 800 


Leu Leu Glu Ser Ala Arg Lys Pro Thr Glu Phe Ile Gly Gly Val Thr 
                805                 810                 815     


Ser Thr Ser Gln Ser Trp Val Gln Lys Met Glu Thr Lys Thr Glu Ser 
            820                 825                 830         


Ser Gly Ile Glu Thr Glu Pro Thr Val His His Leu Pro Leu Ser Thr 
        835                 840                 845             


Glu Lys Val Val Gln Glu Thr Val Leu Val Glu Glu Arg Arg Val Val 
    850                 855                 860                 


His Ala Ser Gly Asp Ala Ser Tyr Ser Ala Gly Asp Ser Gly Asp Ala 
865                 870                 875                 880 


Ala Ala Gln Pro Ala Phe Thr Gly Ile Lys Gly Lys Glu Gly Ser Ala 
                885                 890                 895     


Leu Thr Glu Gly Ala Lys Glu Glu Gly Gly Glu Glu Val Ala Lys Ala 
            900                 905                 910         


Val Leu Glu Gln Glu Glu Thr Ala Ala Ala Ser Arg Glu Arg Gln Glu 
        915                 920                 925             


Glu Gln Ser Ala Ala Ile His Ile Ser Glu Thr Leu Glu Gln Lys Pro 
    930                 935                 940                 


His Phe Glu Ser Ser Thr Val Lys Thr Glu Thr Ile Ser Phe Gly Ser 
945                 950                 955                 960 


Val Ser Pro Gly Gly Val Lys Leu Glu Ile Ser Thr Lys Glu Val Pro 
                965                 970                 975     


Val Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ser Ser Gln Val 
            980                 985                 990         


Asp Pro Gly Thr Asp Leu Glu Pro  Gly Val Leu Met Ser  Ala Gln Thr 
        995                 1000                 1005             


Ile Thr  Ser Glu Thr Thr Ser  Thr Thr Thr Thr Thr  His Ile Thr 
    1010                 1015                 1020             


Lys Thr  Val Lys Gly Gly Ile  Ser Glu Thr Arg Ile  Glu Lys Arg 
    1025                 1030                 1035             


Ile Val  Ile Thr Gly Asp Ala  Asp Ile Asp His Asp  Gln Ala Leu 
    1040                 1045                 1050             


Ala Gln  Ala Ile Lys Glu Ala  Lys Glu Gln His Pro  Asp Met Ser 
    1055                 1060                 1065             


Val Thr  Lys Val Val Val His  Lys Glu Thr Glu Ile  Thr Pro Glu 
    1070                 1075                 1080             


Asp Gly  Glu Asp 
    1085         


<210>  8
<211>  1430
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene DAPK1

<400>  8

Met Thr Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Thr Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 
            20                  25                  30          


Lys Ser Thr Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Thr Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 
    50                  55                  60                  


Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His 
65                  70                  75                  80  


Glu Val Tyr Glu Asn Lys Thr Asp Val Ile Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
            100                 105                 110         


Glu Glu Glu Ala Thr Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 
        115                 120                 125             


Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 
145                 150                 155                 160 


Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu 
    210                 215                 220                 


Thr Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Thr Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Lys Arg Met Thr Ile Gln Asp Ser Leu Gln His 
            260                 265                 270         


Pro Trp Ile Lys Pro Lys Asp Thr Gln Gln Ala Leu Ser Arg Lys Ala 
        275                 280                 285             


Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 
    290                 295                 300                 


Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 
305                 310                 315                 320 


Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Thr 
                325                 330                 335     


Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 
            340                 345                 350         


Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 
        355                 360                 365             


Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Thr Pro Pro Leu Leu 
    370                 375                 380                 


Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 
385                 390                 395                 400 


Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 
                405                 410                 415     


Tyr Trp Ala Ala Arg His Gly His Val Asp Thr Leu Lys Phe Leu Ser 
            420                 425                 430         


Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 
        435                 440                 445             


Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 
    450                 455                 460                 


Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Thr 
465                 470                 475                 480 


Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 
                485                 490                 495     


Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 
            500                 505                 510         


Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 
        515                 520                 525             


Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 
    530                 535                 540                 


His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 
545                 550                 555                 560 


Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 
                565                 570                 575     


Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 
            580                 585                 590         


Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 
        595                 600                 605             


Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 
    610                 615                 620                 


Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Thr 
625                 630                 635                 640 


Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 
                645                 650                 655     


His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His Arg Gly 
            660                 665                 670         


Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro Arg Ile 
        675                 680                 685             


Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr Leu Val 
    690                 695                 700                 


Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 
705                 710                 715                 720 


Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 
                725                 730                 735     


Ala Ser Lys Pro Thr Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 
            740                 745                 750         


Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 
        755                 760                 765             


Leu Thr Lys Gly Met Leu Glu Val Phe Val Ala Pro Thr His His Pro 
    770                 775                 780                 


His Cys Ser Ala Asp Asp Gln Ser Thr Lys Ala Ile Asp Ile Gln Asn 
785                 790                 795                 800 


Ala Tyr Leu Asn Gly Val Gly Asp Phe Ser Val Trp Glu Phe Ser Gly 
                805                 810                 815     


Asn Pro Val Tyr Phe Cys Cys Tyr Asp Tyr Phe Ala Ala Asn Asp Pro 
            820                 825                 830         


Thr Ser Ile His Val Val Val Phe Ser Leu Glu Glu Pro Tyr Glu Ile 
        835                 840                 845             


Gln Leu Asn Gln Val Ile Phe Trp Leu Ser Phe Leu Lys Ser Leu Val 
    850                 855                 860                 


Pro Val Glu Glu Pro Ile Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu 
865                 870                 875                 880 


Gln Val Val Leu Val Ala Thr His Ala Asp Ile Met Asn Val Pro Arg 
                885                 890                 895     


Pro Ala Gly Gly Glu Phe Gly Tyr Asp Lys Asp Thr Ser Leu Leu Lys 
            900                 905                 910         


Glu Ile Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu 
        915                 920                 925             


Phe Val Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu 
    930                 935                 940                 


Arg Asn His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro 
945                 950                 955                 960 


Pro Met Thr His Leu Cys Glu Lys Ile Ile Ser Thr Leu Pro Ser Trp 
                965                 970                 975     


Arg Lys Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val 
            980                 985                 990         


Tyr Asp Val Gln Asp Gln Leu Asn  Pro Leu Ala Ser Glu  Glu Asp Leu 
        995                 1000                 1005             


Arg Arg  Ile Ala Gln Gln Leu  His Ser Thr Gly Glu  Ile Asn Ile 
    1010                 1015                 1020             


Met Gln  Ser Glu Thr Val Gln  Asp Val Leu Leu Leu  Asp Pro Arg 
    1025                 1030                 1035             


Trp Leu  Cys Thr Asn Val Leu  Gly Lys Leu Leu Ser  Val Glu Thr 
    1040                 1045                 1050             


Pro Arg  Ala Leu His His Tyr  Arg Gly Arg Tyr Thr  Val Glu Asp 
    1055                 1060                 1065             


Ile Gln  Arg Leu Val Pro Asp  Ser Asp Val Glu Glu  Leu Leu Gln 
    1070                 1075                 1080             


Ile Leu  Asp Ala Met Asp Ile  Cys Ala Arg Asp Leu  Ser Ser Gly 
    1085                 1090                 1095             


Thr Met  Val Asp Val Pro Ala  Leu Ile Lys Thr Asp  Asn Leu His 
    1100                 1105                 1110             


Arg Ser  Trp Ala Asp Glu Glu  Asp Glu Val Met Val  Tyr Gly Gly 
    1115                 1120                 1125             


Val Arg  Ile Val Pro Val Glu  His Leu Thr Pro Phe  Pro Cys Gly 
    1130                 1135                 1140             


Ile Phe  His Lys Val Gln Val  Asn Leu Cys Arg Trp  Ile His Gln 
    1145                 1150                 1155             


Gln Ser  Thr Glu Gly Asp Ala  Asp Ile Arg Leu Trp  Val Asn Gly 
    1160                 1165                 1170             


Cys Lys  Leu Ala Asn Arg Gly  Ala Glu Leu Leu Val  Leu Leu Val 
    1175                 1180                 1185             


Asn His  Gly Gln Gly Ile Glu  Val Gln Val Arg Gly  Leu Glu Thr 
    1190                 1195                 1200             


Glu Lys  Ile Lys Cys Cys Leu  Leu Leu Asp Ser Val  Cys Ser Thr 
    1205                 1210                 1215             


Ile Glu  Asn Val Met Ala Thr  Thr Leu Pro Gly Leu  Leu Thr Val 
    1220                 1225                 1230             


Lys His  Tyr Leu Ser Pro Gln  Gln Leu Arg Glu His  His Glu Pro 
    1235                 1240                 1245             


Val Met  Ile Tyr Gln Pro Arg  Asp Phe Phe Arg Ala  Gln Thr Leu 
    1250                 1255                 1260             


Lys Glu  Thr Ser Leu Thr Asn  Thr Met Gly Gly Tyr  Lys Glu Ser 
    1265                 1270                 1275             


Phe Ser  Ser Ile Met Cys Phe  Gly Cys His Asp Val  Tyr Ser Gln 
    1280                 1285                 1290             


Ala Ser  Leu Gly Met Asp Ile  His Ala Ser Asp Leu  Asn Leu Leu 
    1295                 1300                 1305             


Thr Arg  Arg Lys Leu Ser Arg  Leu Leu Asp Pro Pro  Asp Pro Leu 
    1310                 1315                 1320             


Gly Lys  Asp Trp Cys Leu Leu  Ala Met Asn Leu Gly  Leu Pro Asp 
    1325                 1330                 1335             


Leu Val  Ala Lys Tyr Asn Thr  Asn Asn Gly Ala Pro  Lys Asp Phe 
    1340                 1345                 1350             


Leu Pro  Ser Pro Leu His Ala  Leu Leu Arg Glu Trp  Thr Thr Tyr 
    1355                 1360                 1365             


Pro Glu  Ser Thr Val Gly Thr  Leu Met Ser Lys Leu  Arg Glu Leu 
    1370                 1375                 1380             


Gly Arg  Arg Asp Ala Ala Asp  Phe Leu Leu Lys Ala  Ser Ser Val 
    1385                 1390                 1395             


Phe Lys  Ile Asn Leu Asp Gly  Asn Gly Gln Glu Ala  Tyr Ala Ser 
    1400                 1405                 1410             


Ser Cys  Asn Ser Gly Thr Ser  Tyr Asn Ser Ile Ser  Ser Val Val 
    1415                 1420                 1425             


Ser Arg  
    1430 


<210>  9
<211>  1255
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene Her2-neu

<400>  9

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  10
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene VEGF

<400>  10

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 
                165                 170                 175     


Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 
            180                 185                 190         


His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 
        195                 200                 205             


Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 
    210                 215                 220                 


Cys Arg Cys Asp Lys Pro Arg Arg 
225                 230         


<210>  11
<211>  189
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene RAS

<400>  11

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  12
<211>  370
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene Wnt

<400>  12

Met Gly Leu Trp Ala Leu Leu Pro Gly Trp Val Ser Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Ala Leu Pro Ala Ala Leu Ala Ala Asn Ser Ser Gly 
            20                  25                  30          


Arg Trp Trp Gly Ile Val Asn Val Ala Ser Ser Thr Asn Leu Leu Thr 
        35                  40                  45              


Asp Ser Lys Ser Leu Gln Leu Val Leu Glu Pro Ser Leu Gln Leu Leu 
    50                  55                  60                  


Ser Arg Lys Gln Arg Arg Leu Ile Arg Gln Asn Pro Gly Ile Leu His 
65                  70                  75                  80  


Ser Val Ser Gly Gly Leu Gln Ser Ala Val Arg Glu Cys Lys Trp Gln 
                85                  90                  95      


Phe Arg Asn Arg Arg Trp Asn Cys Pro Thr Ala Pro Gly Pro His Leu 
            100                 105                 110         


Phe Gly Lys Ile Val Asn Arg Gly Cys Arg Glu Thr Ala Phe Ile Phe 
        115                 120                 125             


Ala Ile Thr Ser Ala Gly Val Thr His Ser Val Ala Arg Ser Cys Ser 
    130                 135                 140                 


Glu Gly Ser Ile Glu Ser Cys Thr Cys Asp Tyr Arg Arg Arg Gly Pro 
145                 150                 155                 160 


Gly Gly Pro Asp Trp His Trp Gly Gly Cys Ser Asp Asn Ile Asp Phe 
                165                 170                 175     


Gly Arg Leu Phe Gly Arg Glu Phe Val Asp Ser Gly Glu Lys Gly Arg 
            180                 185                 190         


Asp Leu Arg Phe Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Thr 
        195                 200                 205             


Thr Val Phe Ser Glu Met Arg Gln Glu Cys Lys Cys His Gly Met Ser 
    210                 215                 220                 


Gly Ser Cys Thr Val Arg Thr Cys Trp Met Arg Leu Pro Thr Leu Arg 
225                 230                 235                 240 


Ala Val Gly Asp Val Leu Arg Asp Arg Phe Asp Gly Ala Ser Arg Val 
                245                 250                 255     


Leu Tyr Gly Asn Arg Gly Ser Asn Arg Ala Ser Arg Ala Glu Leu Leu 
            260                 265                 270         


Arg Leu Glu Pro Glu Asp Pro Ala His Lys Pro Pro Ser Pro His Asp 
        275                 280                 285             


Leu Val Tyr Phe Glu Lys Ser Pro Asn Phe Cys Thr Tyr Ser Gly Arg 
    290                 295                 300                 


Leu Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys Asn Ser Ser Ser Pro 
305                 310                 315                 320 


Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly His Arg Thr 
                325                 330                 335     


Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys Thr Phe His Trp Cys 
            340                 345                 350         


Cys His Val Ser Cys Arg Asn Cys Thr His Thr Arg Val Leu His Glu 
        355                 360                 365             


Cys Leu 
    370 


<210>  13
<211>  439
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene MYC

<400>  13

Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys Ala 
        435                 


<210>  14
<211>  379
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene ERK

<400>  14

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 
            340                 345                 350         


Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 
        355                 360                 365             


Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
    370                 375                 


<210>  15
<211>  796
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  polypeptide encoded by the gene TRK

<400>  15

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


